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<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
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    <name>A0A812AHJ1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_347</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="CAE1139184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A812AHJ1"/>
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    <name>A0A812AMG8_ACAPH</name>
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        <name type="common">Pharaoh cuttlefish</name>
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        <dbReference type="NCBI Taxonomy" id="158019"/>
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            <taxon>Sepiina</taxon>
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                <person name="Bekaert M."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
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    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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    <name>A0A812AMZ1_ACAPH</name>
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    </protein>
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    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">Farmed</strain>
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    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
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    <name>A0A812AN18_ACAPH</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
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        <dbReference type="NCBI Taxonomy" id="158019"/>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">Farmed</strain>
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    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
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        </submittedName>
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        <name type="common">Pharaoh cuttlefish</name>
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        <lineage>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Bekaert M."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
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    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        </source>
    </evidence>
    <sequence length="304" mass="36256" checksum="0321E288EAD9E80C" modified="2021-09-29" version="1">MDIFSVIVGQAPRRRKEKERKSSIRTEIIPTVHIPSSNHSLSRRPEYSLTLSLSQLPYSDYLSIYLSIYLSIYLSIYLSIYLCHSFISIYLSIYLSIYLSIYLSIYVTVVLLIHVLIKYQSHALFLSVSIYLSICLSIYLSIYLSIYVIIFISHLCPSIESSNSLSNIVLLLIFLSFYIHFFLLILIPNRFCSFIFSYFPKFFFHYFLSFFSESFFFHSIIILFLFHSYIPLHISFPIYRFFLFICFHFIQTLSFLFHFLSSFFFIPYFVSFSTLVYSLPFSFIVRVPSLLLRHFFYKNVLFKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ANR6</accession>
    <name>A0A812ANR6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_2335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000064">
        <property type="protein sequence ID" value="CAE1148048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ANR6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1148048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="162" mass="18934" checksum="878A073E2F637122" modified="2021-09-29" version="1">MISKCSIKCSESFLQELVKCSEKLLLQFDDLLISSEVLPGKSDPLRAKQASDFRNPESEKLKVSFEKKRGIWPGVSLVELYTKSLMKSPFSKKTSPLINTVKNTLPQQSTFQSRNDVFQIYVSSFERRIASMEKRKKKLLHEEQRWFEHWKTSIENIKQLFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ARJ0</accession>
    <name>A0A812ARJ0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_2607</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000074">
        <property type="protein sequence ID" value="CAE1149086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ARJ0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="286"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="335"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1149086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="359" mass="41472" checksum="7B4F6039CA2662D0" modified="2021-09-29" version="1">MVVIVALFLFYLPVLLYCFSFLPSPLFFFLSPSTFFFFLDSHKSLLINIHCLFSPDTFSFFLPFPTTLICFFGFFLIFYIFFFSFIFVFFAYISIFSWPTISCSLFISFFLSFLLPSFLFLQFSLCLFIFYSYNFLHLSFHTISFSFINSLYLSICFSFSFTLLQSSFLLLSQSFLTLLSLSLHPPFYFYLFFVPSPFPSSSYSPYLFKEKKLLQAKENYPSFFLSSSFLPSLFILPSVSLHPSFCLPSSFFPSLFLLPSVSLHPSFLLSFPFFCLSPSFCLPSSFLPSLFFLPSVSLHPSFLLSSSFLLSPFILPSVSLHPSFLLLHPSFCLPSFFFPSLFFLPSVSLLPSFCLPFIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AVC1</accession>
    <name>A0A812AVC1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_4884</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000160">
        <property type="protein sequence ID" value="CAE1156698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AVC1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="381"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="427"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="459"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="495"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="529"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1156698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="558" mass="67035" checksum="C9740C98157F3357" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AYD9</accession>
    <name>A0A812AYD9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_7393</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000237">
        <property type="protein sequence ID" value="CAE1162654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AYD9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1162654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="253" mass="28348" checksum="8308B7F60E71EC9D" modified="2021-09-29" version="1">MTIASPLGPPILPGFHPVAVSVLKGPSWPLWPYLRRRILWSVVFLFLPKPSGVGSPRAPLRTQTLFPLWHRMPDDSVPSFPLVPGRSDFCLNFQQRRSIVVFSGLKSLGHHGTIRDVVVSGLIRWSRHHLIMYVCRSVVQFDTGANFYRSFAVDSSLRLELYFFFFFYLGWKFFLSEGSFLAAAFRQSSSSSTWAFLSEGSFLAAGPGMNFNFSSTFGLSAAPILLRLSGNLLLRLLGLEVLLLRLGLEGFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AYE9</accession>
    <name>A0A812AYE9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_7394</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000237">
        <property type="protein sequence ID" value="CAE1162676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AYE9"/>
    <dbReference type="OrthoDB" id="10672851at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="346"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="385"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="410"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="462"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="504"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="581"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="608"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="633"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="664"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="706"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="754"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="780"/>
            <end position="805"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1162676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="806" mass="95882" checksum="3DF9DBC1EE2308B3" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AZE7</accession>
    <name>A0A812AZE7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_9872</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000314">
        <property type="protein sequence ID" value="CAE1168123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AZE7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1168123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="208" mass="24864" checksum="B7E37AA36A8121D9" modified="2021-09-29" version="1">MEEERPSLLNLLSLLFSPYSSLLTLLSYSSLFSYIYQSIYSTKHVLSCKPFGCFYQHISHQLSFSHSLSLSFSPSFVLLYVFLSVTIKFLSFFMSLLFRYNFFHLYLFLLQNLFLSFFISFFFTINFFHSLFLSSSESISFILYPFLLQIQFPSFLISFFFPINFFFSLFLSSSDTIPFILYLFLLQIKCLSFFISFFFRYNFLFQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B0Z5</accession>
    <name>A0A812B0Z5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_8648</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000281">
        <property type="protein sequence ID" value="CAE1165905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B0Z5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1165905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="237" mass="28375" checksum="04A56F5BAF7D6BC9" modified="2021-09-29" version="1">MKLCLIYLSIYLSIYLSHPTHIYLSIYLSIYLISPYSYLSIYLSIYLHPYFIFCPHFLFIERKVLHFFLSSIRSVASFLALFPAPEFFSFFFFRFSLYCFSLYILYCYDFVFYCSNTLGFLFYMVSFFYCITVMRCEIFFSLFLYFFFLSISVCSLSIYLSICLSIYLIQLIPTYLSIYLSIYLSRSFHYLSIYLSMFNIYLSIYLSIYLSIYLSLFIIYLSISLSLPLSFSLSLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B558</accession>
    <name>A0A812B558_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_11619</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000383">
        <property type="protein sequence ID" value="CAE1171518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B558"/>
    <dbReference type="OrthoDB" id="6099974at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF284">
        <property type="entry name" value="EG:103B4.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1171518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="204" mass="22405" checksum="E2AF188A77D58E8E" modified="2021-09-29" version="1">MLASIDLQMIPLTLFLLLSHKHKMKKLAKIDARTKKASSEPIPLTAAFDVSLFKNPIYVTYLCAVAFTLTGCNAMYSFLPTFFHKKGLSLKDAAMLYSLFCIISFVPRASIGFLQRWIKIPFIYIFIALSLLSASLCILIIQAESYFALLSFTIVLSLCMGGPSGLYSIGTLEIVGIEKYSFATSVIETSYGVGTAVFGYLAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B5H6</accession>
    <name>A0A812B5H6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_9559</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000305">
        <property type="protein sequence ID" value="CAE1167707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B5H6"/>
    <dbReference type="OrthoDB" id="26838at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1167707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="281" mass="31150" checksum="E94635425B6DDF45" modified="2021-09-29" version="1">MLGTAAAQAKRRIPRWQMTTKRSKKSYTQTKSWCIYLRAFIVKGFLLSSETVCFDAIPAPKGSRARWRATRVWKENESIEDMIDRLAERLHLPLDGRCRDPGTPLGNIDDELKKVIPDLNDNNILNSPVTVGGLKYAFFDAAPSGAGVVPVWNFKSVELEGMKDIDDLDLSDEAGGDSQNPSMVAERYYMNQSVLGDSPRDMKCRNGDKENMVNGLSTNTILENGDLLNGQAADSYGAEVEMNNERTNGNNNNCCKKQVDASCQTIVTGDILATQFFHEGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B6X0</accession>
    <name>A0A812B6X0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_14063</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000478">
        <property type="protein sequence ID" value="CAE1176249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B6X0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="290"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="314"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="342"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="376"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1176249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="405" mass="47096" checksum="711068F2F4C2998C" modified="2021-09-29" version="1">MITSQHRTHRIYLSIYLSIYLSIYLSIYLLLFVSIYLSIYLSISFCSYLSIYLSIYLSIYLSISFCSYPSISHSVCIYLILFLSIHLSIYLSIHLSISFCSYLSIYLSIYLSIYLILFVSIYLSIYLSIYLSIYLSHSVRIYVSHSVRIYLSIYLSIHLSISFCSYLSIYLSIYLSIYLSHSVRIYVSHSVHIYLSIYLSIYLSIHPSPSVLHPFIYLSIYLSIYPSYLLLFVSIYLSIHPSIYLSISFCSYLSIPFCLYLSHSVRNHLSIYLSIYLSILSMYPSHSVSIYPSIYLSIYPILFVSIYPSIHPSIYLSSISFCSYLSIYPSISFYLLSHSVCIYLSIHSSIYLILFVSIYLSIYLSIYLSIYLSISFCSYLCISFCSYLSIYLSIYLSIYLSDCNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B8M0</accession>
    <name>A0A812B8M0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FREM1_2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SPHA_12739</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000424">
        <property type="protein sequence ID" value="CAE1173582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B8M0"/>
    <dbReference type="OrthoDB" id="6107356at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039005">
        <property type="entry name" value="CSPG_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045658">
        <property type="entry name" value="FRAS1-rel_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051561">
        <property type="entry name" value="FRAS1_ECM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45739:SF11">
        <property type="entry name" value="FRAS1-RELATED EXTRACELLULAR MATRIX PROTEIN 1-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45739">
        <property type="entry name" value="MATRIX PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16184">
        <property type="entry name" value="Cadherin_3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19309">
        <property type="entry name" value="Frem_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51854">
        <property type="entry name" value="CSPG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="FRAS1-related extracellular matrix protein N-terminal" evidence="6">
        <location>
            <begin position="2"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="5">
        <location>
            <begin position="114"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="5">
        <location>
            <begin position="235"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="5">
        <location>
            <begin position="343"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="5">
        <location>
            <begin position="462"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF19309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAE1173582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="671" mass="75747" checksum="770AB48D120804FF" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B9N0</accession>
    <name>A0A812B9N0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_15677</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000547">
        <property type="protein sequence ID" value="CAE1225367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B9N0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="303"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="361"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1225367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="391" mass="48586" checksum="121CC924D46875B5" modified="2021-09-29" version="1">MPLIFFNIFIINISFYSVFLCFLYYFFLFFISLFLSLFHFFSFLLLLLLLFSASYYYLIFLLFYYFFFHTFLFICFFFVVSSYVFLFYSISFVKSLFFRPSVFLLLFFNHFFFLFSFFLCHYRPFCLFFVFFIDNFSFCRLSKLSHLILFFLSPLFFFHSFPVILLTPFSPFISFYQYSFSLFRLLCLLIFFFHSIRLFIIIIFLFLFFSFFSLSAFFILFPFYILLYLISSFSFCFLFCSYFYHFFFFFNPNSFKFLKIFLFCFSFNYSFKSKLKIIFSFHSFLLLFNFVILSFFFQHPFSFFISFFVLSSFSSFWLFLFFIINFFFSFSFLFMLFKIFSFLLFLLFLFVYLLLFKTFFLFILFIIHGFSGFLFYYQIIVFIQNLFSSRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BBC2</accession>
    <name>A0A812BBC2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MRD1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SPHA_14238</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRM MRD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000487">
        <property type="protein sequence ID" value="CAE1176674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BBC2"/>
    <dbReference type="OrthoDB" id="439639at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12567">
        <property type="entry name" value="RRM3_RBM19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12318">
        <property type="entry name" value="RRM5_RBM19_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000277">
        <property type="entry name" value="RNA binding motif protein 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000738">
        <property type="entry name" value="RNA-binding motif protein 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034419">
        <property type="entry name" value="RBM19_RRM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034423">
        <property type="entry name" value="RBM19_RRM5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051945">
        <property type="entry name" value="RRM_MRD1_RNA_proc_ribogen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN 14B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039:SF5">
        <property type="entry name" value="RNA-BINDING PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="176"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="210"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="241"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="323"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="353"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="2"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="399"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="505"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="691"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="806"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="910"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="472"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="768"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="483"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="771"/>
            <end position="793"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAE1176674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1016" mass="119877" checksum="48D01719E6541D2A" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BBK4</accession>
    <name>A0A812BBK4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_14290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000489">
        <property type="protein sequence ID" value="CAE1176786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BBK4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1176786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="245" mass="28120" checksum="DD393C5C1C8CB01D" modified="2021-09-29" version="1">MPILSYKSYRILPDFPASVTDMGVKSASKEEKSFFFNRFPPPPLLLSLLLLFSSSSSSFLLPPLFFFSPSSSLLLLIFFLPYFHLYLFFFLSFSAVTIFFSYVHVVFPSSFLLLSTVHFFFSTSTLCFLDSFFSISVAAKGLHPGPAPDCDAIRGEIMTTTAYTDISFNTYLLLIYLSNAFQIYLSIYLSMYLCIYLSIYLYNRFQMSLSVSLSIPRRNKFKNVYPILPKIYNYIVCFSLKESPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BC42</accession>
    <name>A0A812BC42_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_14012</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000474">
        <property type="protein sequence ID" value="CAE1176112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BC42"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1176112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="396" mass="47778" checksum="6BDFB820E188B534" modified="2021-09-29" version="1">MPFSFFLPYVFFFLSFFFFLSYVFFFLILFFLSFFYLILSYDFFFLSFFLSFFLSFLISFSFILSYVFFFFSFFLSYVIFLSFLMSFSYFLSYVFSFFLSFFLFLSFLCLFLFYFLFSFFLITLSFFSFLSFFLMFSFFLSFFLSYFLIFFLLSFSFSLILFFLFNYFSSFFSSLSLTVSFFHSYIYLFHLSLFSSSFFYFCLIFFLLSFFFFHFFLFLFPLLFFLSFLIFFAYIFLLSFSLYPSLIYPLFSDCFFRRPFLSHFSIIFFPFCLAFLTLHFQPSIFFILSSQYSFLSPCSSSLSIPHALTTNLLLYLNIPPIFIVPVCYSPDLNSCFPIDLLSKFLPHNLPPPLSFHFLLRYSNLICLCKPHSLIIHNDIPNPSLPLTHPTSPHPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BDG4</accession>
    <name>A0A812BDG4_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VIT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_17895</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000641">
        <property type="protein sequence ID" value="CAE1230859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BDG4"/>
    <dbReference type="OrthoDB" id="299997at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013694">
        <property type="entry name" value="VIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08487">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00609">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51468">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="457"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="VIT" evidence="2">
        <location>
            <begin position="769"/>
            <end position="903"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1230859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="960" mass="108525" checksum="47F60AD467BD7450" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BDV0</accession>
    <name>A0A812BDV0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_14932</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000514">
        <property type="protein sequence ID" value="CAE1177941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BDV0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1177941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="203" mass="24192" checksum="1DCB6F3096932252" modified="2021-09-29" version="1">MRSLNNHYFLFFISCLLIFFSPLPSPFICSFPLQPFFLFSHDIFALSVSLSTSFIISSSSSSSFLFLFHLFFSLYSFPFTISHSFFPSLSLFSSFLIFPSFFLFLLSHFILTCFPSFFFLMLLLFFFLYSWSLHAPQCVICYYFILFNDFYKRIKQGEFKEKKIRCSHLDKCVHNVFACFNTHFPLKTNKKEEYIQILHCFQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BDX5</accession>
    <name>A0A812BDX5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_14900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000513">
        <property type="protein sequence ID" value="CAE1177881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BDX5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1177881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="241" mass="27647" checksum="E82BE9C631EC6CE7" modified="2021-09-29" version="1">MFLLYFSLSLSLYLSIYLSIYLSLSLSLSHTHTHTHTFPPSHSTFQAIGDPSPPTNSPDIRHVNLRLNVSRASGLCYSSLLARTAHLSPFLALHFPLTPFPSFSLFLSRGISRYFLYYLPESISFDSFFPSFLSKSNNKYFVCLFISLSIYILLFISICICSFLSIYLSIYLRPITNSLYIYLSIYLSIYLSIYLPNIFSTITAALVSGELIHYSLMKHDSTNQIFYQIHPAQFLESEFYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BEJ6</accession>
    <name>A0A812BEJ6_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">type I protein arginine methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.319</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SPHA_14136</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Farmed</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-arginyl-[protein] + S-adenosyl-L-methionine = N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48100"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11990"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65280"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:48101"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.319" evidence="2"/>
    <dbReference type="EMBL" id="CAHIKZ030000480">
        <property type="protein sequence ID" value="CAE1176438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BEJ6"/>
    <dbReference type="OrthoDB" id="7848332at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035242">
        <property type="term" value="F:protein-arginine omega-N asymmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000003">
        <property type="entry name" value="Blast:Protein arginine N-methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.160.11:FF:000007">
        <property type="entry name" value="Protein arginine N-methyltransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055135">
        <property type="entry name" value="PRMT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006:SF102">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06325">
        <property type="entry name" value="PrmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22528">
        <property type="entry name" value="PRMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein arginine N-methyltransferase" evidence="10">
        <location>
            <begin position="246"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="469"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="469"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="481"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF22528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAE1176438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="495" mass="55727" checksum="0930FC2CB3022785" modified="2021-09-29" version="1">MKRHGLPIRRRKSVGASTARKDVVAREMNKLPLPFGMSNTNILLTKPYQNYSEPDVDSFSMPSTVVKLEPTSDSEDGDISNKCAQNKSQNVKLSGASCSNEYFNSYVDISVHELMLKDKPRTLSYMQFIDQNKHLFNGKVVLDVGAGTGILSCFAARAGAKMVYAVEASNMASICESIVYQNDLQDQITVIQQPVEDVILNCRYVDIILSEWMGFYLLHESMLDSVLYARDKWLSPNGGIMLPSYACLCMAPVAMKKYHSEHFAFWKNVYGFDFSPAIPLAMEKFFKQPIIEVVKEDQLMSSPQKILDIDLKTVTLSEVQFLSKELHFKMEKSGSLHGFVSWFDVVFLDPNGKVPESKLVLSTSPNSELTHWKQTVFFLPTPLLVDANDSIPCNLTLFQDTANKRHYNICIEVPVDIVQEDSQTDENLNITADDIENPEQHSIPCNCNAPRCKIIKVIMEKYTDEQAELQNNDEVTVTSEEIGEDSELDASDSTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BF02</accession>
    <name>A0A812BF02_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_14374</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000491">
        <property type="protein sequence ID" value="CAE1176916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BF02"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="295"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="360"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="388"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="479"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="501"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="531"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="557"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="636"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="667"/>
            <end position="687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1176916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="689" mass="80766" checksum="D7BEBED79BB048FD" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BFF1</accession>
    <name>A0A812BFF1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_14600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000500">
        <property type="protein sequence ID" value="CAE1177370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BFF1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1177370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="266" mass="29822" checksum="CA2498E6FA0D497D" modified="2021-09-29" version="1">MTVGDNFFLPIFFSLAFPFISLSLSLSFLSRLSFLFSLSLSRLPFLSLSPSLSLSLLPFLSLSPSLSFSLLPFLSLSFPFFLSLLPFLSLSLLSSLSFPFFLSLLSFLPLSPSLSTSLAFPFFSTSLAFPFSLSRLLSTFTLSPSLYFFSLAFSLLFLSRLSFTFSLSPFLYFFSFNKHNFIMSFCLSFSADLSLALCLHHCLLLLCLFLSLPVHLFVSPFLYTFLPDCIFVALLLSTSLSLFTSIPVSLCLPIYLVICLFFTVHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BGR8</accession>
    <name>A0A812BGR8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_16327</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000572">
        <property type="protein sequence ID" value="CAE1227271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BGR8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1227271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="484" mass="54964" checksum="164CDE99FA14C5BB" modified="2021-09-29" version="1">MEWLSYVVLAGATHPHQYKPFCEGWGWLTRQNPTFANSPQPFFFSTVRPFVLALSSPSSISYQVHSSVNSSLQHPGTLNIVFFSSIIFPLGRIGHPGKLFSSLQSSFRSVELNIQEHCFLLFNHLSARIEHPGTLFSSLQSSFRSVRSVEDIQEHCFLLFNHLSARIGHPGTLFSCLQSSFRSVELNIQEHCFLVFNHLSRSVELDIQEHCFLVFNHLSARDIQEVFLSSIIEHPGTLFSCLQSSFRSVELDIQEHCFLVFNHLSARIGHPGTLFSLSSIIFPLGRIEHPGTLFSCLQSSFRSVELNIRNIVFLSSIIFPLGRIDIQEHCFLLSSIIFPLESEHPGTLFLLSSIIFPLIGRIEHPGTLFSCLQSSFRSVELDIQEHCFLVFNHLSVELTSRNIVSFSIIFPLVRIGHPGTLFSCLQSSFRSVELNIQEHCFLCLQSSFRSVELDIQEHCFSFFNHLSPRGHPGTFFVLNHLPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BIT5</accession>
    <name>A0A812BIT5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_21069</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000775">
        <property type="protein sequence ID" value="CAE1238052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BIT5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1238052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="314" mass="37329" checksum="AA4ECA0F3D523267" modified="2021-09-29" version="1">MRKFVDVVNYSPVIEKTTVALLASFLCIYLSIYLSIYLFSVLSYLSIYLSILISCSFSLFISLSLHFYPPIYLSIYLSIYLSIYLSIYLSIYFHSFISICLCIYLYQIVYLFHHIYIYLSIYLSIYLSQSIYSSSFISIYVSIYIKLFIFFTIFISIYLSIYLSIRVALYLSVYVSIYIKLFIFFIIFISIYLSIYLSIYLSIYLSLYIRVFISIYQMYLSISNCLSFSPYLSIYLSIYLSIYLSIYLTYRSFFNHLTLSKIIKPLGLKSLLRLIFHLSIYLSIYLSIYLSIYVFYLSIYLSIYLSIYLSIYLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BK41</accession>
    <name>A0A812BK41_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_21789</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000802">
        <property type="protein sequence ID" value="CAE1239506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BK41"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1239506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="204" mass="24351" checksum="76EC9ED81969D43E" modified="2021-09-29" version="1">MKWQRNDRYFFSGGVTNSVKGIRRINIFRFIYLPSVLLFFFHFMGDRVSFVYLSIYLSIYLSIYLSIYFNLFLFCSYLSIYLSIYLSITNYSDLSIYFSLFLSIYLSIYLSIYLSIHHNLFLSLYFSLFLSIYHNLFLFLYLFQSVPIYLSIYLSIYLSIYLSQSLFIYLSIYLSIYLSIYLSQSLLISLSILVCSYLSIYLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BKM5</accession>
    <name>A0A812BKM5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_17818</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000636">
        <property type="protein sequence ID" value="CAE1230589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BKM5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="348"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="373"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="406"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="437"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="494"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="550"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="582"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="615"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="640"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="682"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="708"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="737"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="779"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="812"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="837"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="862"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="898"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="923"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="955"/>
            <end position="973"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1230589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="975" mass="115757" checksum="1F8E9A856D2645E4" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BKR4</accession>
    <name>A0A812BKR4_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Short-chain dehydrogenase/reductase 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Retinal short-chain dehydrogenase/reductase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SPHA_19217</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Farmed</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the reduction of all-trans-retinal to all-trans-retinol in the presence of NADPH.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000698">
        <property type="protein sequence ID" value="CAE1234048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BKR4"/>
    <dbReference type="OrthoDB" id="10253736at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052650">
        <property type="term" value="F:all-trans-retinol dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05339">
        <property type="entry name" value="17beta-HSDXI-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000131">
        <property type="entry name" value="Short-chain dehydrogenase/reductase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322">
        <property type="entry name" value="PKSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322:SF736">
        <property type="entry name" value="RETINOL DEHYDROGENASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="6 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00059620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00082544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAE1234048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="228" mass="25692" checksum="74CB4A89F86C0D2A" modified="2021-09-29" version="1">MIQKIGGVAHTYYCDVSQKHQIYQVGERVKKEVGDVTILVNNAGVVIGKGFMDCPDDEILNSFNVNILSYFWTIKCFLPKMIENNHGHIVNMSSSLGLTGLNKLTDYCSTKFAVVGFNEVLSYELKHDLHNGIKTTLICPQCVDTDMFKGCNIRFPSICPFMEVDYVVKKSITAILTDQYMLCLPRLVYFQAALKSLLPADSWIETCKFLGTMTFMDSFIGNKKKCTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BMT0</accession>
    <name>A0A812BMT0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_19495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000707">
        <property type="protein sequence ID" value="CAE1234738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BMT0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1234738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="316" mass="36395" checksum="BADC2209FA07D1AA" modified="2021-09-29" version="1">MNDYLILRLFYIYLSIYLSIYLSIYLSKQRQRQMTLFSPPSHRLYKCFDCLFVCFFLSFFLPSYLSQSVHIYLSIYLSLCISISLSIPVCAYLSISLSLYLSQSVHIYLSTSVCAYLSIYLSLCISIYLSIYLSIYLSIYLSIYLSLCISISLSTSVYAYLSIYISISVYAYLSLYVSQSVHIYLSIYLPQSVHIYLSIYPSLCISIYLSIYLSIYLSLCISISLSTSVCAYLSIYLSLCTSISLSISVCAYLSIYRDFPSIAQMWHRAESMGHPRDKLANHCTTSRCPYLSIYLSIYLSIYLSIYLSIGYFIFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BNM5</accession>
    <name>A0A812BNM5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_18896</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000682">
        <property type="protein sequence ID" value="CAE1233250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BNM5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1233250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="198" mass="23268" checksum="745BC06CDB2488AC" modified="2021-09-29" version="1">MVYSSLNTENASNSLKPTLLSIYLSIYLSIYLSKFSYLSTSIYLYLSIYLSSLFLFIYLSLLPIHIYLSFYLLISYLSIYFVCSYISIYLICSYLSIYSVYIYPSFYLSIYLVCSYLSIYLSMRFISIYLSIYLSISSIYLSIYLSICKSVISDTPFEFLEESNHFPETPFVFSFCILIFLLFLSNRISHSLFIYLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BQV2</accession>
    <name>A0A812BQV2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_22262</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000822">
        <property type="protein sequence ID" value="CAE1240339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BQV2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1240339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="206" mass="24917" checksum="7DDE7632FFB55FFE" modified="2021-09-29" version="1">MSSYINLICISQSFKIYLSIYLSIYLSIYLSIYLSQAMRAHPNFFLFFFIFSFYFFILYPSFLHVHLLSFFLSFFLSFFLSFYFFLFSTRLLFAMLNFFLSFFLFLSFFLSFFRLHPSIPKFILLVLSCLEQSPKCRTYIMCLSTIHFLLLPSFLPPSFLPSFLPSFLPSFLPSFLPFHFFHLSLSLYLFLSFFLFRRLYFFLTFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BS97</accession>
    <name>A0A812BS97_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_22676</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000840">
        <property type="protein sequence ID" value="CAE1241106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BS97"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1241106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="204" mass="24025" checksum="AD94AAAFFEA06238" modified="2021-09-29" version="1">MFLRLRSWAYFRVFSVAITYFRLSIFVFLFSLHIFIFIFLPFIHNFLLFLLFLLVYNLYSLSSSLLHHYISFFSLNLFRTYFLFFFFFPLSLVRSPTFSSLTISCSSSASLTFFIHSLTHSLLLVFIHSFIPLSLSINSSIPLSFSLNQTLSYSSLSSSFITHSLLTNIFSLLFILFFCTCNLNHLFHFLSFFLSFFLCLFSFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BUZ7</accession>
    <name>A0A812BUZ7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_23187</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000857">
        <property type="protein sequence ID" value="CAE1242124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BUZ7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1242124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="263" mass="29850" checksum="65869A365A3098F0" modified="2021-09-29" version="1">MHEEACLSIYLSIYLSIYLSIYLSIFIAFSIFMPIYICFHLLSLSFSPDIFLGVLKSSPLTKQPISAPAFFFFFFFFSSSSSFSSSSSSSSPPPPPSSSSSSSSSSSMRQDQNISPRLSPYDKKYSSLSILIRSKYLSGHSSRIKMSFFGYLGRIKIFPLDSLILHHCLSLYDQNIYLDTLLESKCPSLAILDQNIKLVYLPEIKLFHSDSLPRIKSSLFVYFLRIKIFLLNSVTLSLSLSLSLSLSEEEEEEEKEKIRKEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BW41</accession>
    <name>A0A812BW41_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_25092</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000948">
        <property type="protein sequence ID" value="CAE1246324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BW41"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1246324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="244" mass="28675" checksum="77529BB1983333D8" modified="2021-09-29" version="1">MYDNAGYIIDQRNFISCFCLPLLFLSLLLFFYISHFSLSLSLSLSPFLVSFSLSSVIIFILIFIFSIPSLPLSLFLCRPLSYLSLSLFFYISTLSLSLSLSLFPYSLYLFLYLPLIFSFRLSLFSFFFYPFLIFLLFSYFFIVSTFLSFSQFFFISFCAFFSNLLQLLVFLFLFCCCFFSLFLHAIFSHNLSRAFILFFFHFIPFNLFNSSNPRAYFLLLMSFSSPLLNAAVFFLFFFLLSQSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C1S2</accession>
    <name>A0A812C1S2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_25587</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000968">
        <property type="protein sequence ID" value="CAE1247284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C1S2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1247284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="221" mass="26499" checksum="93AF1939DEC65CA2" modified="2021-09-29" version="1">MSYIFKSIRLSFQIFFPFSQHPSFDDRAHHPFFVISVPLFFSFPPFSSHFPSRFSSFHFYPFFRFSLNPFPSFRYNFFLHYIHSLVVISFQLYLSISYPFFGVSFLLPTLHYIFPTDILFTYSLSYRLIFPFPSIIYFIPALFLSFLSSHIRSKYSFISFFSHLSSFFFHNRFLLLYFSLHISSFLSFVFLALFPFFLSVVLPQFLFLNPFAKRLGTVQCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C2X2</accession>
    <name>A0A812C2X2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="15">FBN2_3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SPHA_26232</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fibrillin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001001">
        <property type="protein sequence ID" value="CAE1248444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10045365at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001527">
        <property type="term" value="C:microfibril"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000005">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000038">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000003">
        <property type="entry name" value="fibrillin-1 isoform X1"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000068">
        <property type="entry name" value="Latent transforming growth factor beta binding protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000002">
        <property type="entry name" value="Latent-transforming growth factor beta-binding protein 3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000014">
        <property type="entry name" value="Latent-transforming growth factor beta-binding protein 3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000017">
        <property type="entry name" value="latent-transforming growth factor beta-binding protein 4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000010">
        <property type="entry name" value="Pro-epidermal growth factor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000096">
        <property type="entry name" value="Putative fibrillin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000653">
        <property type="entry name" value="Putative Fibrillin-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000008">
        <property type="entry name" value="Signal peptide, CUB domain, EGF-like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="44"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.290.10">
        <property type="entry name" value="TGF-beta binding (TB) domain"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026823">
        <property type="entry name" value="cEGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024731">
        <property type="entry name" value="NELL2-like_EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017878">
        <property type="entry name" value="TB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036773">
        <property type="entry name" value="TB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052080">
        <property type="entry name" value="vWF_C/EGF_Fibrillin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47333:SF5">
        <property type="entry name" value="FIBRILLIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47333">
        <property type="entry name" value="VON WILLEBRAND FACTOR C AND EGF DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12662">
        <property type="entry name" value="cEGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12947">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="38"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14670">
        <property type="entry name" value="FXa_inhibition"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00683">
        <property type="entry name" value="TB"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036312">
        <property type="entry name" value="Fibrillin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="46"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="45"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57581">
        <property type="entry name" value="TB module/8-cys domain"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="39"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="28"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="34"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51364">
        <property type="entry name" value="TB"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="9 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 11" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="domain" description="EGF-like" evidence="13">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="TB" evidence="14">
        <location>
            <begin position="39"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="13">
        <location>
            <begin position="143"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="TB" evidence="14">
        <location>
            <begin position="189"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="13">
        <location>
            <begin position="297"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="13">
        <location>
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</entry>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1256487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="271" mass="29980" checksum="73EB07FE1F00E108" modified="2021-09-29" version="1">MPNFGEIPPRRRRSSVSIISIHPDFFLLTSQFISIYLSIYLSIYLILSISIYPSSLSIYLSIYLSIYLSIYLIVFICIYLTLSIAHRHQIDPFHRSQPYFFLVRFGVVGPSQLTLAQAPTFLRPFFGVGKVDISSSSSHSLSSSSFSGGFESELRNSSLTFFAFLKAPRRHWNGATSSQSPLSNDADTNYERTPLAATVGRRACTWTTMLCSPVKGSTDCGLISISSSYSEPSSVSISSGPTRVTLLLFAFLLRGPVTFQPLISASFRSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CB87</accession>
    <name>A0A812CB87_ACAPH</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
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            <taxon>Sepiina</taxon>
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            <authorList>
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                <person name="Bekaert M."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001264">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000597762">
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    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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    <feature type="transmembrane region" description="Helical" evidence="1">
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        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
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    <sequence length="1815" mass="202004" checksum="74E222A827486308" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CC96</accession>
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        <submittedName>
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        </submittedName>
    </protein>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">Farmed</strain>
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    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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                <person name="Bekaert M."/>
            </authorList>
        </citation>
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            <strain evidence="2">Farmed</strain>
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    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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            <begin position="321"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAE1260313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="373" mass="38665" checksum="E92CAFD1D1E22CD4" modified="2021-09-29" version="1">MSLNNLLLSLSLSLSLSLSLSLSLSLSLSISLKIYIPALFTLSFSLSLSLSQTLTLRLSASLSLSLFSLSSVCLLSLSLSFSQTLTLRLSAPLSLSLALSLSVYLSPSLSLSLSDSYSPSVCSSLSLSLSSPSLPLSLSVSLSPLSLSLSLTLSVCFSLSVCLSLSLSLSLSETLSSVSLCSYSPSVCPLSLSVSFSLSLSPTVSVCLFIPLSLSLTLRLLLSVCLLLSLSLSLFLCLSLFLPPSLSLSDTYSPSVCSSLSVSVSVSVCLSFSLSLSLSQTLTLRLSALSLSLSLSVSLSPSLSLSLSLSDSYSPSVCSSLSLSVSLCLSFSLSLSLSFCLCLSLFLFLSLSLSPSLPLSFSLSPSPSFSLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
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    <name>A0A812CEG7_ACAPH</name>
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        <recommendedName>
            <fullName evidence="12">Phospholysine phosphohistidine inorganic pyrophosphate phosphatase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SPHA_33754</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
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    <reference evidence="14" key="1">
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            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Farmed</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Phosphatase that hydrolyzes imidodiphosphate, 3-phosphohistidine and 6-phospholysine. Has broad substrate specificity and can also hydrolyze inorganic diphosphate, but with lower efficiency.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>diphosphate + H2O = 2 phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="3.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HAD-like hydrolase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.1" evidence="5"/>
    <dbReference type="EMBL" id="CAHIKZ030001418">
        <property type="protein sequence ID" value="CAE1263536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CEG7"/>
    <dbReference type="OrthoDB" id="426235at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000051">
        <property type="entry name" value="Phospholysine phosphohistidine inorganic pyrophosphate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006355">
        <property type="entry name" value="LHPP/HDHD2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01458">
        <property type="entry name" value="HAD-SF-IIA-hyp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288">
        <property type="entry name" value="4-NITROPHENYLPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288:SF44">
        <property type="entry name" value="PHOSPHOLYSINE PHOSPHOHISTIDINE INORGANIC PYROPHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13242">
        <property type="entry name" value="Hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00039357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAE1263536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="382" mass="41469" checksum="432ECC36941347B0" modified="2021-09-29" version="1">MTFFSRTSNPFLPSIRVRVVPFGVVHISLTRTVSSQPSSPLPPLLSELFGSAPGPSFSSIPWPLEGSSYSIPESFASPAILSSNSSLVSPFCCCCRNNFLTAVLPHQGGFKLGPYKGRVFFVPLPMNLDTCPAASSSSIFFLSITPKTVFCLEPDISYYGSMRDILVARRENGGKVIEGSVNAVQRLNKAGIPVFSPIPAVCAILKERNLRPFLLVSPDALDDFKGIDTNDPNCVVIGDFNNGFSYEIMNKVFRFLKSLSNPVLFSLGCGKYYQDNGKLVLDVGPYMKALEYACDITAEVVGKPSPDFFKAALNDLGLKPAEVVMIGDDIINDVEGAQALGMRGIQVCTGKYRPEDKIHQIVKADGYPKNLAEAVDLILSQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CFI9</accession>
    <name>A0A812CFI9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_34892</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001491">
        <property type="protein sequence ID" value="CAE1265832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CFI9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="334"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="370"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="415"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="700"/>
            <end position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1265832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="742" mass="84062" checksum="ADD55F69EBAEC387" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CFL4</accession>
    <name>A0A812CFL4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_32639</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001360">
        <property type="protein sequence ID" value="CAE1261290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CFL4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="338"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="370"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="394"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="434"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1261290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="468" mass="57490" checksum="2F1EB2B02269F990" modified="2021-09-29" version="1">MFPCLKNCICLYLYVSRLNLSFLFTFVLVFLYCIYLFSNLRSRPLFFFYIWFYFSLSCISFLLSFFHSFFPSLLLSFFPSFFHSFSFFLSFSHFFFFFFLSFFFLSFFPSFFLFPFSFFLSYLLSFFLYLFSFFFLYFLLSIFLSFFHLSFILSYILLSVFLSFLLPYYLIYLFSNYYFFYFSLILFFLTFYFYFLLHYISINYFFFFLFSFFLISISSSHSFFSFSSSSLLFIYLLTTKAICRCFFFFFLLLLRLFLHSHFLFLLINSFILLSFLHIFISYFSRYLPAILSFFLSFFLSFFLSYFYFFVPLVCFHSRTFFISFLFFISSLYNSQIFFFFLYYLFFFFLSIFFVFFLYSSSRSLSHSHSFFLFRHILFFSHLSIYSLIRRSAAVVFSFSFFYFHSFTSTHAIVDPSFLPPPTLSLSLPRRYGDLLFVFFIFFFFLFLLLIFLSFLLSLYQLTSIHFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CFL5</accession>
    <name>A0A812CFL5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_33316</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001393">
        <property type="protein sequence ID" value="CAE1262611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CFL5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="303"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="332"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="390"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="421"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1262611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="460" mass="56556" checksum="D1171BE6F4EF55CD" modified="2021-09-29" version="1">MHGDLLVCINIYVAAVDGRHALITPHPLFVCLFLILSFFLPSFLCLLPLFLLFFSFLLALFICFFLSFSLLSFACYLFSFFLSFFLSFFLSFFLSFFLFTFLFYLEKRTCFFFTFFSFLSFSFFFFSFYFFLFSFFLFFFFLSFFFLFFFPLLVNSFLSFFLSFFLSFFLFFFLFTVYFLFFLSFYLLSFACYLFFFFSFLSFLLCSFVCFFLSFFLPSFLCLLSLFLSFFLSFFLSFFLSFFLSFTWNLFSFFLSFFFFLSFFLNFLPSFLWFCYLFFSEFLFFLCLFLILFFSFFLSFFSFFSFFLSIHCLFLILPFFLPSFLCLLSLFFFLYFFLSFFLSFFSLKILFFLSFFLSFFKIFFLLFLSFFFSFLSFFLSFFLSFLSFLFFFLSFFFFLFFSFFFLSFFACYLSFSFFLLPFFLLFFTFPSSLVYFHLNFDPLIKKKKKKKTTIIHFALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CFP3</accession>
    <name>A0A812CFP3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_32697</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001366">
        <property type="protein sequence ID" value="CAE1261392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CFP3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="296"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="343"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1261392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="398" mass="47361" checksum="91D8CC22E6FF94C1" modified="2021-09-29" version="1">MLHTTRAAAATSDPIPFSFCSLLLFLIIFFSVFLSLFISLCFLYEFFFVCLLYFSYNKFFSLVYSFPFFAKSHLSIQFTFLDLTFPFTLYIHPFYFYFHPCFFFSLSLSLLLTSFFFLSFFLSFFLSFFLCLPFTLPLFFPLSHSLSSPSFFLFLFWFSLHIFLFLSFYLSHLSFFFFRYLALYIDYLFFYLLLTLSFFFSISFSLSISFSLSLSFTPPYSLYLFLSLSIFISHHFTLSPTLPLAPFFFLSFFLSFFLFLTFFVSHSYRLFFLCLSLSLSILLPFFLSFFSFLCLFRIYIILYFLFLSFSLLHTFGHSLFFPCLSFSLSLSFYLFFLPLSHSFSFLCLYQVFSPFIFPSANYCYLKFSFCLIHPFPSEISGRRVCIIHTQTNVLNSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CHC0</accession>
    <name>A0A812CHC0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_34750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001480">
        <property type="protein sequence ID" value="CAE1265545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CHC0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1265545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="178" mass="19529" checksum="51EDC361CC2C6096" modified="2021-09-29" version="1">MTPRLDYTARAHRVSGLLNILPGIIACRIHPIHGVLWLGSPISHLLNPSLPFLAASSPINLPLFREANVLSRNLSFTLSMTSFYSLCSSVVVFFFSFVFLTVLFLYFLFSFPPFIPIIIFIVSLSPLSFPLPSLFPSPLSLPLSPLSFPLSLPLSLSPPSLSLTLSLSLSLSLLRVNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CI77</accession>
    <name>A0A812CI77_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_34097</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001442">
        <property type="protein sequence ID" value="CAE1264227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CI77"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="324"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1264227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="351" mass="44383" checksum="0BD396353E29A830" modified="2021-09-29" version="1">MNSNREVKILQASIYLYLSFIYTAFHNFFIFLYFSIFLNIFFPFLFLEFLLSFHFFFLYFNIPFLYFKLVYFSECLLSFSSFHYFYFYTILLFSIIHFLDILLFSSIFFLSFIFCIFFYYLVCFFFLTIFLLYTFFYHSFLSILFFSFFFILQFCIFPYLSSLIFSHNSVIVHILYSIFLIHFCPFFFLSFSSFIFCLFFSFILIFLSFLYYSFLYIFISFFFIFILFIYHSFLYILFSFFLFFFHFFIIHLCIFSFLSFFLFFFHFFIIHFCIFSFLSFFLFFFHLFYHSFLYILFSFFLFIFFFSFFIIFFCTFLFSFFFFFFLSFFIIHFCIFSFLSFFLFFFHLFYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CLI1</accession>
    <name>A0A812CLI1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_37052</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001637">
        <property type="protein sequence ID" value="CAE1270957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CLI1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1270957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="254" mass="30627" checksum="C930AFBAD55A70E6" modified="2021-09-29" version="1">MGKEKTGLIYGGSGQYCSSSFLCNLSIYLSIYLSIFYLSIYLSILSFFLSFNFPLNTHFLLFNLVSFFIQSSSQSFFLSILLSTFSFFLRFNFSFFLSFFLSFFLSFFIYLFIYFLSFFFLHCINISLCIYLRILERINFFFLSFHSLFLSFYFNSNFFLSFFFLSFFLSFFLSFFLSFFLSFFCFICSSSSSSSSSSSSFFLSFFSFFFFFFFLFLFPFTYYFFFLSLLRTNLFFFLSIYLSIYLSIYLNFFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CN99</accession>
    <name>A0A812CN99_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7041 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_39138</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001803">
        <property type="protein sequence ID" value="CAE1274876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CN99"/>
    <dbReference type="OrthoDB" id="6159822at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055469">
        <property type="entry name" value="DUF7041"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327">
        <property type="entry name" value="ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327:SF3">
        <property type="entry name" value="RNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23055">
        <property type="entry name" value="DUF7041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7041" evidence="2">
        <location>
            <begin position="9"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1274876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="261" mass="29822" checksum="7016450D903C37C7" modified="2021-09-29" version="1">MTAAVTPFPPFHEGNIKNWFLQMEAIFTVRRITDQKTKFGHVVAVLPPAIVDEVADFLEAVPEVEPYARLKEAILRRMGRTEESLIRELFSNLTCDGRTPSQLLRYMKSRLGKNTMADSILKSLWLDRLPTTITQILAPMSENTPIDQLADAADRIFSQLDQQTTPVHSAEATKDHRSLEKTVEDLQRQVRDLTLAQKSHGRSRFPSRRRFRSRPRSSSRNKDATSTMCYYHRRFGSAAHYCTVYKPCSYTAVAENKTASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CRE8</accession>
    <name>A0A812CRE8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_38671</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001768">
        <property type="protein sequence ID" value="CAE1274176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CRE8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="154"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1274176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="171" mass="20718" checksum="1DB7799E936A2BC8" modified="2021-09-29" version="1">MSCDRSRPMGPSRASFLLPRTSRDRPRPMRLWSGVFPPPSCIRVTNCQIIFLSYIVFTFFFRRILLFLFLHLILKSFTWFSRFSYFSFPSSHRHSLSSTATTFLFLSLFFFLLHHHYHYHQHLLLLLLLLTFSFLLFPFLFFLVFLFFLLRSPVLLFSFLLFILPYFFFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CZ58</accession>
    <name>A0A812CZ58_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SpeG</fullName>
            <ecNumber evidence="5">2.3.1.57</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SPHA_42889</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Farmed</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.57" evidence="5"/>
    <dbReference type="EMBL" id="CAHIKZ030002113">
        <property type="protein sequence ID" value="CAE1281408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CZ58"/>
    <dbReference type="OrthoDB" id="7305308at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004145">
        <property type="term" value="F:diamine N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000064">
        <property type="entry name" value="GNAT family acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051016">
        <property type="entry name" value="Diverse_Substrate_AcTransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10545">
        <property type="entry name" value="DIAMINE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10545:SF29">
        <property type="entry name" value="GH14572P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="7"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAE1281408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="173" mass="20145" checksum="B702F6BD98AA5E86" modified="2021-09-29" version="1">MTTTEKFIVRPGRVEDCDEVHRLIKELAIYEKMGERVEITPEVLKQHGFGDHKYFHVLVAEISESEDLATGTIGGYLLYFYGYDPWQGKYLYVEDFYVTPECRKIGMGSALWKTVIKTAAKEQCEWMEWCVLDWNHLAINFYKRYGAVNVTKEAGQIFRLTSKEVENVLAKIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CZP1</accession>
    <name>A0A812CZP1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_43330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002168">
        <property type="protein sequence ID" value="CAE1282212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CZP1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1282212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="208" mass="24966" checksum="B1B10E1A0A76F338" modified="2021-09-29" version="1">MSLVLFSLSLSLSLSLSLSLSLSLWRLARSYRNISRTSLSSTFLSFFLSFFLSFFLSFLFLSRTSLSSTFLSFFLSFFLSFFLSFSNFTFSLLFFLSFYLSFFLFFLSFLFLSRTSLSSTFLFLSFFLSFSFFLFFFLVELHFPLLFFLSFFLSFFLSFFRFYFLVELHFPLLFFLSFSLSFSLSFFLSFFLSFFLSFSFLFYLEHLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D2R8</accession>
    <name>A0A812D2R8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_46469</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002455">
        <property type="protein sequence ID" value="CAE1287262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D2R8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="298"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="376"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1287262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="448" mass="53597" checksum="8740298852508AC5" modified="2021-09-29" version="1">MITSIEWTWPSEIKKCRFNFSLVLFLFPSHHFPDLDLFSFFFFLTLQPFNGRFLFSFSLSCLIHSLTSLTREMFISSLVRYTFTFSYWTYVIFFSLIVFSFHNLLSSSNYLTFSSSIPLSYLRQPLNQRVTFSSSIPLSYLRQPLNQKNFFFVYLFLLFRSASQPTCHFFFVYPSLLFTSASQPTCHFFFVYPSLLFTSASQPTCHFFFVYPSLLFTCHFFLFHILFLLFCPIRFLHFFYFFLFFPFFHIFSLFIYILFNFSLPYLLFLFTTKTSSFLFLVCPSLSFYFFSFFFRLKLFLFHLYSFFLQLKLCLSFSYFSFPFLYYRFFVFFLSSPSFFISVYLSLLSLTSIISLHILSLLLSVSLFVFIPPRLPIFYHFIFIVGVILVAEANHQVPHSDQYHHPFIHFHFQQKIEYITEIHGHTVSTSLSQAPQIIQTHNHLMLSDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D3J5</accession>
    <name>A0A812D3J5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_49333</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002811">
        <property type="protein sequence ID" value="CAE1292547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D3J5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1292547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="188" mass="23011" checksum="DB817DBAAD33FD0D" modified="2021-09-29" version="1">MLFYYQYFKVFSFHIFAENIVSFSHYTIFHHSLYITCLFFLSFFLSFFLSFFLSFFLSFPALFLSFFSRLLFLSFFLSFFLSFFLSFFLTCIFHFLCFTFLDYVNISLNLTYFDFRFSFFLSFSITLNVLSFLFFPSYFFSFILYIFFPLFLCFLLSVLLSFFFLSFFPPVILSFFLSFFLSFFLSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D6E4</accession>
    <name>A0A812D6E4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_46830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002501">
        <property type="protein sequence ID" value="CAE1287935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D6E4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="295"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1287935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="323" mass="39609" checksum="953B170DBF761573" modified="2021-09-29" version="1">MTISSNDLIFHHFFQSVSKTLFGSFFFLFLSNIFFFSVSIFIIMSRFFISFWFLSPFFNLFWFLSFFLSFFLSFFLSFCLSVFLSFFLSFVLVSFFLFCFVLVSFFLSFIHFSFFLSFIVFLSFFLSFLFRFGVFLSFFLSFIRFSFFLSSFFVSFWFLSFFLFCFVLVSFFVCFFLSFVLVSFFLFIFFVSFWFLSFFLFCFVLVSFFLSFFLSFVLFLSFFLFCFVLVSFFLSFLFCFGFFLCLFLSFIRFSSFFLSFYLFCFVLVSFFLSFFFILFWFLSFFLSFFLSFNHFSFFLSFLFRFGVFLSFFLSFFLSFFHSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D761</accession>
    <name>A0A812D761_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_48481</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002700">
        <property type="protein sequence ID" value="CAE1290918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D761"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1290918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="198" mass="24903" checksum="6B6A5751929ED827" modified="2021-09-29" version="1">MHYFTFFFLSCHLFVFQFCFYYLNFILYHFRIYSYVIFGPFQLKLSFTIFFHSILFFLKLSLFLLLSILFSFSFFYCFLFVFYLLYFLFFIHFIYFFLPFIFCISHSVFFILPFFFSYFLFSFVFSFLFLSFYYLSFCHFLFSFIFLLFQFFYLCILLSFFLHFSFIFLVFLFYSLSFFCHFVLFHFSSFSSFLLTSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D7A3</accession>
    <name>A0A812D7A3_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Gustatory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_46509</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002457">
        <property type="protein sequence ID" value="CAE1287318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D7A3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032455891" description="Gustatory receptor" evidence="2">
        <location>
            <begin position="21"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="273"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1287318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="335" mass="37859" checksum="8701B197738C4778" modified="2021-09-29" version="1">MVYFVCLSVFLSLSFSLSLSLSLTHTHTYTNTPSLRLLADLSLPLFLFYFIRNFFLIHSFSFFLSFFIYFHLFLNGFPSLFLSFSCISGILYLIFLSFSLSLVLYSFFFLSLFLSFFLSLCVFLSLSFPLFYRVFLSQSFFPSFFFSLSLSFAFTLSLGLSFFLVFVFSFHSNFLYHLLFRHLSLSLSFAFFTVSLSLYSLSPSLSMSLSSLSLSLSLSLSLSHSLRQLFFFVCFGLIGVSYSFSPILLSSSITFSLLFYFSLSLSLSLSLSLSLSLSFLFLFIFVSIPLGGAFANISKRHGTAAPRSPELIAATNVMSQQRPSSISLHRSAINP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D7E7</accession>
    <name>A0A812D7E7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_46572</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002468">
        <property type="protein sequence ID" value="CAE1287419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D7E7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1287419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="210" mass="23836" checksum="246BDBF7CF5301AF" modified="2021-09-29" version="1">MLWKTTIYLSLPMCKVQAGNLQRHPSPVAVLSTFNATGFQEHMAVVFIQQPAHDLFIVVISCTAQCTLSPSKQHRRFFSSFFFFSFFILLYFITLPFLPSFLPSFLPSFLLLDHNHHYLLLLLLLLLLLLLLLQSIYSHLFSSSSSSSFSSSSSSSSSVPPPPPSSSSSSSFFLPPLLFIIIFLFDFLPSFFVSFFFFSLFLSFLILSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D7J5</accession>
    <name>A0A812D7J5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_48175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002655">
        <property type="protein sequence ID" value="CAE1290135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D7J5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1290135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="234" mass="27519" checksum="AB2D122BC5977C90" modified="2021-09-29" version="1">MLAKRFFIFKISSTRTFQILPTHTSLVSIYLSIYLSIYLSIISIHIYLSIYLSIYLSIHSYIYIYISIHMYLSICLSIYLSIYISIIVYSCVCLYIYLSISLYIYHSLYISIYLSIIVCSYLSICHSLFISIYLSIYHSLFMCLSLCLSISLSIYIYHSLYISIYRSSFVHICLSICRSLFISIYLSIYLSIYHSLFMCLSVCLSISIYIYIIVYTYLSIYLSICRSLFISIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D8Q2</accession>
    <name>A0A812D8Q2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_51451</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003109">
        <property type="protein sequence ID" value="CAE1296417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D8Q2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="334"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1296417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="364" mass="44076" checksum="A5130AF3A328C9D3" modified="2021-09-29" version="1">MTQSHESSKYYSIYSFSLSFSTLSIYLSIYLSIYLSIYSFSLTIYIFSLSIYLSIYLSIYLSIYLLFLSLSLYLLFFSIYLLFSFFLSLSEVEEKETRAVSKKKKFFSYIINTLFLFFFLFALFSFSSFFSILPLLFAFFHFLFFFIPLFFLLLLHHHHLFLVFFFLVALFSSSLFLVAFLPYTLLSHYCSFLPLPLSLSLRFIFFPHFFLFHFSSSLRLLPLPLFFPSSPSSFPFLSVRFIFFFIFLFSLSAFLPTFSFFFFFFIIIFLITLLYFFFFFFFFFLFSSSSLYSLWFLLPLFALFTIPFFLFTFFTSSTPFSLRSLLLPPLSLRFIFFFFFFFFFFFFFFFFFFFFIFLQMCGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D957</accession>
    <name>A0A812D957_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_49196</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002790">
        <property type="protein sequence ID" value="CAE1292289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D957"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1292289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="261" mass="28417" checksum="4A238945DCE49C60" modified="2021-09-29" version="1">MGRLSWRAQIGGQYPVRWGFQPGREHHHADGGSAWRHNRCRVALPRRIGETCANRVAGLALRDRLERDSCSAATSRIDSTPSAPTNSASCHPRRATIAGGQRDGDGVGQEQQQRTLNTVQLAVAILKPTTPAAASARWRSLRHHRHCRPGSAHRRPPRRRAARRVVEQRGGARPAISLVMVCTGDRVTNTTDQRDRDDRPRDQGRGGAAHLARVEGRDAETQPDDPGIINGDNSIAPMSTATEGINSPSSEIAADTTIRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DB95</accession>
    <name>A0A812DB95_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_50602</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002998">
        <property type="protein sequence ID" value="CAE1294838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DB95"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1294838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="217" mass="25560" checksum="CCF00D9C021E652E" modified="2021-09-29" version="1">MACEEPLPFFGRNDNRKMTRNPQADIVRLSFSPHFTFLFLSFFLSFFLSFLLSFFLTLFFLSFILSVCISFFELHAPFLFLNHISNIHSLHISSYSFIHSFIHSFFLFSFFESSSSFLFLSHTSVFLFLHISPYSFLLSFVLSAFISFFELHSPFLFLNNIYQTFILSAFHPTLSFFLSFFLSSSPFSFSIIYQTFFLATIHPTLSFFLSFFLSFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DBM6</accession>
    <name>A0A812DBM6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_48881</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002763">
        <property type="protein sequence ID" value="CAE1291713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DBM6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="316"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="350"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="389"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1291713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="407" mass="47399" checksum="D0CB94B6ACE236D7" modified="2021-09-29" version="1">MLCQSIPLSSGDFPLTKTLNNIYLFLPIYPSMCVQSSIYLSIYLNLFISISVCSYLLSIYLSIYLSMYLLIFSTVHFYLQSVHFNLSIYLSQSVNIYLSLSYLSICLCLSIYLLSIYLCLFIFNIYLSIYLSSIIYLICFIYLVCSYLSIYLSIYLSILSIIYLSQTVHFDLNLFIFYLSIYLSFYLSIYLSIYQFILLISISVCSYLSLFSLSLYLSISVSSIYLSIYLYIYLSISVCSYLSINLSIAVCSYLSIYLSIYLSIYLSIYLSISSVSIYLSIYLSRQSYTFIYLTQPVSIYLSIYLSIYLSRQSYTFIYLTSILYCIFGGYLSIYLSIYLFNCYHYLSSSIYLFLSVYILTLPLFIYLSIVLFIYLIICSCFFSPFISPLSIYLSIYLSIYLSIYLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DCT2</accession>
    <name>A0A812DCT2_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cytochrome oxidase subunit I profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_53514</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003413">
        <property type="protein sequence ID" value="CAE1299960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DCT2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023616">
        <property type="entry name" value="Cyt_c_oxase-like_su1_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50855">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="351"/>
            <end position="379"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="385"/>
            <end position="409"/>
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        <location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        <location>
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            <end position="562"/>
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            <end position="731"/>
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            <end position="762"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="794"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="827"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="833"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome oxidase subunit I profile" evidence="2">
        <location>
            <begin position="231"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1299960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="852" mass="103776" checksum="60F21D75879E7B37" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DEV3</accession>
    <name>A0A812DEV3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_51653</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003142">
        <property type="protein sequence ID" value="CAE1296796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
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        <location>
            <begin position="354"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1296796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="387" mass="46808" checksum="334FE72A11FA5DD5" modified="2021-09-29" version="1">MFFFLFSFSRSFFLFSSSFSFFSLSLVLSFFFSSFFLSFLFLSLLFSFFSLFSFILFVFSFSPFFLSTLFLSFLLTFFSLFLVLSFLSFSYFLSFLFLSFFLSSFSLSLVLFFLSLVLNVFLFRFSYSYFFFFFLSVVLSLILFSFYRSFFLFSFSRSYFLSFLASSFLSSLFLFFLVSFFSRSYFLSSSFLSYFLSSPFLSSFILLSFFSSFLLSSLFLSFFFFLFLVLSLFIFSFLRFLFLFSFSRSFFLFFFFRLFFLFSFLTFFILSFFFFHIQCLLINFLTFLICSFSFSLFLFLPFFFVFLFFLSFVSLLLSIYFFISQHFSFFLFFFIILSFFFLNTRLFPPLLPSFLLSSFLSFFFLSFFLSFFFLSFFHSVFLSLFNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DHR5</accession>
    <name>A0A812DHR5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_53895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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            <taxon>Decapodiformes</taxon>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
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    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003443">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DJA4</accession>
    <name>A0A812DJA4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_52892</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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            <taxon>Spiralia</taxon>
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            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003326">
        <property type="protein sequence ID" value="CAE1298812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DJA4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </feature>
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        <location>
            <begin position="284"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1298812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="327" mass="36939" checksum="2617CB7CF47D8B6B" modified="2021-09-29" version="1">MVYLHLPRWVGYLHLPAGLSYEGWLSLPRWVGYLHLPRWVGYLWVGYLHLPAGWLGLVYLHLPRWLVIFTCPAGLVIFTCPWVGCWLVIFTCPAGLVIFTCPAGLVIFTCPAGLVIFTCPAGLVIFTCPAGLVIFTCPPLVGYLHLPRWVGYLHLPWLSSGLVIFTCPAGLVIFTCPAGLVIFRLVIFAPLVGYLHLPRFIFLVGYLHLPCWLVIFTCPAGWLSSLAPLGWLSSLAPLVFFVFAFFFQLLVELLFWSLLVFFFFLLFSLFFFFSTFFFTFVSTLLFFSTFSLLFFLFFPCFVIFSRGNALGNVSSAQSISNVKTLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DK25</accession>
    <name>A0A812DK25_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_58204</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003966">
        <property type="protein sequence ID" value="CAE1305822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DK25"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="13"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1305822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="333" mass="39110" checksum="E8DD0970B97B8079" modified="2021-09-29" version="1">MTYNLFSFIPYEYYLRILSLCTILGFITLIQSSYIYLSIYLSIYIYIYIYIYIFMSICYLYLSIYLILIATSIVLYLSLSILSISVSSIYLSHSVHIYLSIYLSSVHLSISILFRSHLFISIYLTYLSIIYLSYISSISISDYSYLSVSVYIYQFQSVHNYLSISIYLYLSIYLSIYLSHLSIFWTLSISQSISILFTISSIYLISVHIYLSIYLIHLSIIICLSQFHIYQFQTIHLSICLSISVYQFQTIHIYLSQSISINFSLFITTYLSIYLSIYLSIYLSIYLSLYLSISDYSYLSVSVYIYQFQSVHNYLSIYLSIYLSIYLTLAISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DMP6</accession>
    <name>A0A812DMP6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NFXL1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SPHA_57131</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Farmed</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NFX1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003837">
        <property type="protein sequence ID" value="CAE1304563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DMP6"/>
    <dbReference type="OrthoDB" id="536399at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034078">
        <property type="entry name" value="NFX1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000967">
        <property type="entry name" value="Znf_NFX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12360:SF1">
        <property type="entry name" value="NF-X1-TYPE ZINC FINGER PROTEIN NFXL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12360">
        <property type="entry name" value="NUCLEAR TRANSCRIPTION FACTOR, X-BOX BINDING 1 NFX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00438">
        <property type="entry name" value="ZnF_NFX"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="NF-X1-type" evidence="6">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="NF-X1-type" evidence="6">
        <location>
            <begin position="47"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="NF-X1-type" evidence="6">
        <location>
            <begin position="126"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="NF-X1-type" evidence="6">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="NF-X1-type" evidence="6">
        <location>
            <begin position="228"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAE1304563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="295" mass="33444" checksum="AFAEB27196359485" modified="2021-09-29" version="1">MKFKPPRCNQNCRIPSDCHHPLRKPHRCHFGSCPSCDEVCDKPLTSCGHKCPELCHDVIKVKKKVNPLLYAGNNNIPQFDIIKKPCPPCIEPMKLECLGKHEINEFTCSQLGPYSCKRPCGKQLACTNHTCTLDCHEVIDAPDEKSAGSNCAKCEYECLRKRPQGCNHICLLPCHPGDCPLCVQMFRIRCHCRSIQKHIECFKWSSTDQDTRNNLKSCGQECPKIMSCTHKCNQVCHSGECDPKGCDKKKSIRCKCKRRKKEFSCLQVMSGKAQLPCDEGCNELKLKQQRVISSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DMS3</accession>
    <name>A0A812DMS3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_56523</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003744">
        <property type="protein sequence ID" value="CAE1303784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DMS3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1303784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="156" mass="17830" checksum="587BF90F83A521D2" modified="2021-09-29" version="1">MLPSASPFLSFRLKDESRFFLIADISVTHVTLHHFNAENLHFFSSVCTTLGKGRRRLLLFDRSELFSLNGVRTSKLLRPHSFLLSLSAFICSCFCVDNKPSFLLSPFSLSFNTRSLCSVFYFSKPFFLFLLPLRPFCNITSLSLSLSLSLFLSFVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DSS8</accession>
    <name>A0A812DSS8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_61559</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004366">
        <property type="protein sequence ID" value="CAE1309903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DSS8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="323"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="361"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="400"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="436"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="467"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="499"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="536"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="560"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1309903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="593" mass="73003" checksum="FB520C16C7333EDC" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DVW0</accession>
    <name>A0A812DVW0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_63427</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004545">
        <property type="protein sequence ID" value="CAE1312151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DVW0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="372"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="401"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="490"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1312151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="530" mass="61277" checksum="1F93F1D3FC4FD676" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DXC0</accession>
    <name>A0A812DXC0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_60841</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004253">
        <property type="protein sequence ID" value="CAE1309046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DXC0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1309046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="296" mass="36048" checksum="9D7D21FD99B8B0A8" modified="2021-09-29" version="1">MLFVLVSFFFFSFFFSLFHSYLFPFFHFFFSLYLRFIFLYRSFFSVPSVSRIFLYTCLFSFVFFSFSFGSLCFSSFFSFLGFFIYSFLLFFFFSVFLILYLFYILSFLLFYFTSETRPLDIFLFTFFYRSYYSSIYFIFSSLRLFYFPVLSFLCNRCFIHIFLLFGFMPSFSFLINYLSGLFCFHFSFFVPFLILSSFFLLLFLFRNVCWLPSCLYSIPFLFFSSLLPTFLPSLLSFYHAYSLSVFLHLFLFFCVILFLNLISILFHASFLFYSFILSGFLSHTFFSCFFLIYFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DY11</accession>
    <name>A0A812DY11_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_63629</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004566">
        <property type="protein sequence ID" value="CAE1312389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DY11"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1312389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="179" mass="20499" checksum="DC729654CF17E071" modified="2021-09-29" version="1">MRFARALKIPRTFGLHFAQAHISIYLSIYLSIYLSIYLSIGLVRGQHHLNSFLVFSAFLSLNIIQTIPSTPVTIAYRHDFYLLFPSLTLSLLLSLTLSQRYALYILQTQFLSADWIYISHKSTHSEIYSLTPSLNSYYCSSLTYILSLSFSLSTLFLSPFCLFVPLSFSSFLFLTFLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DYE8</accession>
    <name>A0A812DYE8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_62850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004498">
        <property type="protein sequence ID" value="CAE1311455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DYE8"/>
    <dbReference type="OrthoDB" id="6161790at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1311455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="200" mass="22936" checksum="D14565BAD9267670" modified="2021-09-29" version="1">MAGQVSKSGVVGAGEEGDIISPSQHTSDSMPYLTIVCNIYLSQSVNIYLSIYLSIYLCLLISIYLSFYLLISIDLFIYLHLIISIYLSINIYLSISSVHIYLSISVCSYLSIYLSIYLFESVHIYLSIYLSIYLFESVHIYLSIYLSIYLSIYLSIYLAVCSYLSLYLSISVCFTLSISVCFYLYIWWRKGWGRDECIGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DZP2</accession>
    <name>A0A812DZP2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_63594</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004561">
        <property type="protein sequence ID" value="CAE1312340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DZP2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="293"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="322"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="367"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1312340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="401" mass="47370" checksum="4E63FECC677BA7D4" modified="2021-09-29" version="1">MSQQYAWTTTSSKILFFFFHLLPNPFKKFSLATYFLYTSLTLNFSTTLQFLSTSPHFFHTLCFFFFSLYTFFLLSVHFFLTLFLLLFTAHFFPNPFSALFYCPLFSNPLSAFFTVHFFQTLSLLCFTVHFFRTLSPLCFTIHFFLTLSTLFFTVHFSSLYFFFSQPLSTFFYCPTFFFFIFQTLSTLFLLSTFFKLSLRFFYCPLFSQSLRFALLSTFHTVLLLCFTVHFPHCLSALFYCPLFSLSLCFFLLSTFSLALFYSLSLCFYIFTVHFLTFSLLFLLSTFLTISLLFFTVHFFTCTFFTLSLSVFIFLLSTFSPSLCFFYCPLFSVSLHFLLSISISLFSFSHFSLFSSSKHSHILSHFNFFFFLLHFSSLLCFSYSPSFLFLTFALFFTNNTFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E0V0</accession>
    <name>A0A812E0V0_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RCR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="5">2.3.2.33</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">SPHA_62617</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Farmed</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-threonine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-3-O-ubiquitinyl-L-threonine.</text>
            <dbReference type="EC" id="2.3.2.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Axon</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RING-Cys relay (RCR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.33" evidence="5"/>
    <dbReference type="EMBL" id="CAHIKZ030004486">
        <property type="protein sequence ID" value="CAE1311201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6050183at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008582">
        <property type="term" value="P:regulation of synaptic assembly at neuromuscular junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19799">
        <property type="entry name" value="Bbox2_MYCBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16463">
        <property type="entry name" value="RING-H2_PHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000078">
        <property type="entry name" value="E3 ubiquitin-protein ligase MYCBP2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004939">
        <property type="entry name" value="APC_su10/DOC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45943">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MYCBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45943:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MYCBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01337">
        <property type="entry name" value="APC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51284">
        <property type="entry name" value="DOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="12" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DOC" evidence="16">
        <location>
            <begin position="927"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="15">
        <location>
            <begin position="1631"/>
            <end position="1682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="34"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="104"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="207"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="254"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="363"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="613"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="822"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1445"/>
            <end position="1465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="35"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="208"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="254"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="655"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="822"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="832"/>
            <end position="844"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAE1311201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1881" mass="208761" checksum="8F7838C82FA80134" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E115</accession>
    <name>A0A812E115_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_62732</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004489">
        <property type="protein sequence ID" value="CAE1311305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E115"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="362"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="392"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="425"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="479"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="506"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1311305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="556" mass="65916" checksum="1F0ADF1B9DE9FB64" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E168</accession>
    <name>A0A812E168_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_65971</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004744">
        <property type="protein sequence ID" value="CAE1315006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E168"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1315006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="259" mass="30345" checksum="D1AA5F373CD6484A" modified="2021-09-29" version="1">MGGCLSTQYEKLSSHLRKGILISLSLSFFLTFFFFFLQILEFSLFHIFTLSLFLFYTFLLFSPLPVSPSPSSFSALFLSAASPFSFCNFVCSLFFSLLISPLDSSLCPFSPILIYYTFLLLTHSFLSPSLFSVTVRFFIHLSIYLSIFSFFFFFSSSLSFVFLNLNCRHQKSTFLMLLIFKIILSVCTFFFSFLLRRPNSNVFLSLILHKEFFLRFLSPFLKHLLPLFIQFLLICQTLPRQSYTCYTLTHFKKSFLFHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E643</accession>
    <name>A0A812E643_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_65084</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004686">
        <property type="protein sequence ID" value="CAE1314038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E643"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1314038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="174" mass="21488" checksum="8473A3F2F5A2DD5B" modified="2021-09-29" version="1">MSSWICYTTSRNKEEISIVWEVKEHDNGLKRKQHFTQKNNILSSFLSLSLSLSLSLSLSIYLFISLFHNSSFGFNKISRWTFFLFRFILFSFFHFQFLFFFFLHFSLLFFLSFFLSYIFSFLFFLSFFFLSYIFLFFLSFIFDFFLFSFLTFFFSFHFFFFLSLFRFLSLSFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E7V8</accession>
    <name>A0A812E7V8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CABIN1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_66398</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004787">
        <property type="protein sequence ID" value="CAE1315461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E7V8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="103"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="197"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="233"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="304"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1315461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="349" mass="43343" checksum="507937940D04F695" modified="2021-09-29" version="1">MCDTKIAMIESFYDESMWRLRQRIIFFLISTHNKMTSHYHNPPPSPLFRYVIFFHFHSIILGFMYFFFYFDFFVYLPFLLFILYLLVYYCFFQLQIYSRFLSFFILSLFFHFFFFFLLKFFLSFFLSFFLSFFRYLNIFIFSPNFFFYRLLLTFFLSFFLSFFLSFFLSFFLSFFLSFLSVFLSFFLSFFSVFKYFYFLSKLFLLSSSFFLSFFLSFFLSFFLSFFSVFKYFLFSLQTFFFYRLLLTFFFSFFLSFFLSFFLSFFLYVCLSVFLSFFLSVFVCLFVSFFLSFRYLNKLIFFPNLFLLSSSVNILSFFLSFFLSFFLSFFLSVFLSVFLPLFLSFFLSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EB44</accession>
    <name>A0A812EB44_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_67677</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004897">
        <property type="protein sequence ID" value="CAE1317040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EB44"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <begin position="12"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="80"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="320"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="353"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1317040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="385" mass="47595" checksum="498781F1ECC579A8" modified="2021-09-29" version="1">MLEICRYQFLSFIFYILSFFLSWCHILYFFFFVLFFIFFILSFFLPFLHSFLFPYFIFLYSFVYFFHILYSFFLPFFLSFFLSFFFPFFLSFFFPFFLSFFVPFFPSFVHILCPVLWFLSFLSFFLSFVLSFFLSFFPFFLTILPSFFSYLLILSFLLSFFLSFFLSFFLSLILSNIFLSFFLFSFFLSFFLFSFFSLLFSPFVFLFFFLLFFVYLCFFLSFLLFHIYLFFLSFLLSIFPSLLSFFLSFFLFLILFPFVSYLLILSFFFFLSFFLSFFLSFFLSFIFSFFSFFLFSFLPSFFLSFPYYSPLSFFFSFSCFSLFIFVSFFLSFLIFFLPFHSLFFLALFDYSNFLSFFLSFFLSFFLSFFLSFFLFFSFPKLSLRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EBW4</accession>
    <name>A0A812EBW4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_69829</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005106">
        <property type="protein sequence ID" value="CAE1319412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EBW4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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            <begin position="37"/>
            <end position="54"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="88"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="295"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1319412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="312" mass="37134" checksum="B02409AE3D232D2F" modified="2021-09-29" version="1">MTERSVKSDTRFLSFNSILPLFYKPHFQVSIYLQHRLAFFSVILSFLHTLLLLLNLPLPSLMIPLYLYFSSSTFFYHSPLSFPTLLIIPRFPFFLLLPSLYYSLCFPLFIVLYHSLILLLSHYVIFFPFFCFLPPFFIILFFFRNPLTHISILLLLLLLSFLHLFFIIYHVLNRFPFLCTLLYFFHTFTTSPSLFFSYPQFIIIFFLSFSFLRFAFISFLFSFPTRLPIHFLLSLLPPLLSVYYFFIFYSLTLPISLYPSFLLPHFLTTLSFLLLLSVITLFAILRFFVQPTHTPPLYHSFLLLLILLLLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EET1</accession>
    <name>A0A812EET1_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dynein heavy chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_73869</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
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            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005398">
        <property type="protein sequence ID" value="CAE1324107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EET1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="240"/>
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        <location>
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        <location>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
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        <source>
            <dbReference type="EMBL" id="CAE1324107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1009" mass="117152" checksum="45FFC6590BD95CDA" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EG51</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
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    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <source>
            <dbReference type="EMBL" id="CAE1324976.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="217" mass="25277" checksum="00EF8C0D911CD01E" modified="2021-09-29" version="1">MALSLSLSLSLSIYHYLIFLSFSISFICRFIFLSFSIFHSLSFLSLSLSLSLSLSVLFPLLLIISLSLTIYLPCFSLAFFHFSLSSLSFLAFSFFPPSLFFMLLSFYHSSIFLLLHSLALAYHFQFIFLSNFRINFISRPVFLVLFVISFSFIVSLFVFFLSSLSFFSFSRSPSFFSFAFSHFFLISFYFIFPLFQFIYLSVFFSCIIFIVSLSFFL</sequence>
</entry>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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    <name>A0A812EJ18_ACAPH</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
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        <lineage>
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            <taxon>Coleoidea</taxon>
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            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
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        </lineage>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
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                <person name="Bekaert M."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005433">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <location>
            <begin position="219"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1324850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="247" mass="28660" checksum="B31F6F47BE0E8CAD" modified="2021-09-29" version="1">MIFLFTPPFSSFSLHLLSPLSLYTSFLLFLFTPPFSSFSLHLVSPLSLYTSFLLFLFTPRFSSFSLHLVSPLSLYTSFLLFLFTPRFSSFSLHLVSPLSLYFLSFSSFSLLLIFLLFLFTFYLSPLSLYFLSFSSFSLLLIFLLFLFTSYLSPLSLYFLSFSSFSLLLIFLFTTHLSLSPPIFLFKPPFSLPLIFLFLSIFLYTFPLFLSFFLTSLFPIFLSTSPLTIYLHSHSFFLHILFLPDISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
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    <name>A0A812EJU0_ACAPH</name>
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        <submittedName>
            <fullName evidence="5">SMARCAL1</fullName>
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        </submittedName>
    </protein>
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        <name evidence="5" type="ORF">SPHA_73835</name>
    </gene>
    <organism evidence="5 6">
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        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
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        <lineage>
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            <authorList>
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                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="5"/>
    <dbReference type="EMBL" id="CAHIKZ030005398">
        <property type="protein sequence ID" value="CAE1324033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EJU0"/>
    <dbReference type="OrthoDB" id="2801544at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010003">
        <property type="entry name" value="HARP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45766">
        <property type="entry name" value="DNA ANNEALING HELICASE AND ENDONUCLEASE ZRANB3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45766:SF6">
        <property type="entry name" value="SWI_SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY A-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07443">
        <property type="entry name" value="HARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51467">
        <property type="entry name" value="HARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HARP" evidence="4">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAE1324033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="155" mass="17474" checksum="6AD7CBEA772AA5AB" modified="2021-09-29" version="1">MIEAGFHTGLISLFKTMETKEYNAMTKCWSFRLTEYEKLMKQAKSLQPEVLIIPLPKIVLQTFSDAIAGRTTTSQIPKADITALDSCLVKTLMSFQLESVFLGIHRKGRILLADDMGLGKTIQAIALACYYRKDWPLLIVVPSSVRFDWAQVSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EJY5</accession>
    <name>A0A812EJY5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ESRP1_2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_75241</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005454">
        <property type="protein sequence ID" value="CAE1325605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EJY5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1325605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="335" mass="40139" checksum="070B0C7301DC04B1" modified="2021-09-29" version="1">MLNASKRSPFSQKTTAAQRCHKRVWGGVIVSVTFCSSSQIPLNISQVFLSPLFIFLSFFLSFFLSFFLSFFLSFFFLSFFLSFFLASFLSFFLSFFLSFFLSFFLSFFLASFLSFFLFLSFFLFLSFFLSFFFFLSFFLFFFSPFLSLFFLFFFFLSFFLSFLFFFFLSFFLSFFSFFLSFFLFPFSFLSLFFLSFFLSFFLSFFLSYSFRSFPFHTAFSLFLSFLFVCFFLSFFLISFVLFRLTLPFLSIAFLFFFLSFFFFLKRMNAWIYSVSATRLFSLSLSLSLSLSLYLSIYLSIYDTWKKNLTFCRRNSSGNLTISIYLSIYLSIYLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EQC2</accession>
    <name>A0A812EQC2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_75468</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005459">
        <property type="protein sequence ID" value="CAE1325848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EQC2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1325848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="276" mass="31834" checksum="09375EF4E3149E56" modified="2021-09-29" version="1">MRLLIRHQQANVLSPLAFSLFNSKSSLSFFFFFFFFFAVHVPHSLALIMCIFFLTLSFTFSNLPSNHCKLTLQLLLPLLFSPYPPSISLSFSLHSLPHSLNSFFFLPLFVSVFLVTFLFFLFYHPLTTSRILLSLSFYYFLPVSPLPITFPTLSLSLSLSLSLSFYIYFATTSFLILPLPVFPFSHYSSFFLCSYNFFLSLFFLLFSFFTDLPFPSSHLLPIHSISFPFSLFIFSLPPCVFLFSFCLILMSLSPSYVTISLFSFPLLLLTYLISTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ESB6</accession>
    <name>A0A812ESB6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_80014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005588">
        <property type="protein sequence ID" value="CAE1330743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ESB6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="273"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1330743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="302" mass="35506" checksum="9DCAA425BB1AF2F3" modified="2021-09-29" version="1">MTYFSFPPISLFAFPPFSIHYLFTFISYSYYYPQSLNLFSFSGLSTQSYLLFLFLSYVFFLFPIIFRAFSLSPLFLSRFLSFSFLQSLCCLLIHEKHVDACLSYLSVTSSIFFCLSSACILCIFSPFYFFQVFFFSLPIPIFSVPISSTSPVLIRFSLSSLASPAYLHLSHVRLGIRRKQTPFLQILSLFYGFYHCPNILIRSFQYSVFLQIPLCFFFLKIFSIFIKTRPSLLSVLFLFLLPLIFHSSFYYRVVLNSSFFYRLFVNSSFFYRLLFNSTFIYYLVFNSPSFTAWSLFPLSFPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EUF7</accession>
    <name>A0A812EUF7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_79633</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005574">
        <property type="protein sequence ID" value="CAE1330332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EUF7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1330332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="235" mass="27595" checksum="629C6120FDEED226" modified="2021-09-29" version="1">MNPFLLSPSFFTRYTFFYFFYLSAIRLYFLPLKYISRFVFLGSFFFLFCVLLFSSLPVSFFSSGVFLLFPCLSSLVLSCLALSFLLFYPCLSFSSTLVFPSLLPFSFLSFSSTLLFSFLLFYPSLFFFLLFYPSLFFPSLLPFSFLSFSSTLLFSFLLFYPSLFFPSLLPFSFLSFSSTLLFSFLLFLTSAVFYFIYLCLTYSLLFKFLSLSVITNLLYTFFLCFYSFLSLPFYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EUP2</accession>
    <name>A0A812EUP2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_81242</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005628">
        <property type="protein sequence ID" value="CAE1332164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EUP2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1332164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="290" mass="34314" checksum="A45010E17E894115" modified="2021-09-29" version="1">MGRPVNTSLSLSFSLFFCLYLCKKLSIYLSIYLSIYLSIYLSISFFFNIYLSIYLSHSFIHLLYLSILSLFSLFLLFLYLRFIFVLFLTYFHSHFFIAFIFPTSRAIVLNLIVFRYFFVSFSCIFVFDYFLTFLISHFCQSLPSLSLSLFLPLPLSLSFSLSFYCLLYRTVHFSLSSIHFYSLYLSRSLSALPLFLVSIYFYLFYLRHFRSSLSLPTRSSLLFFLSSHLYNFSYSYTLSLSLSLSLSLSLFLFIPYSCSFFYFFSLFFFLVPFSTFLLHKPTISLGYFCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EVH8</accession>
    <name>A0A812EVH8_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Attractin/MKLN-like beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SPHA_80237</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005595">
        <property type="protein sequence ID" value="CAE1330969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EVH8"/>
    <dbReference type="OrthoDB" id="8185403at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056737">
        <property type="entry name" value="Beta-prop_ATRN-MKLN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051746">
        <property type="entry name" value="Kelch_domain_containing_8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46260">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46260:SF3">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24981">
        <property type="entry name" value="Beta-prop_ATRN-LZTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Attractin/MKLN-like beta-propeller" evidence="3">
        <location>
            <begin position="75"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAE1330969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="308" mass="34413" checksum="A125FD1B3631E4DC" modified="2021-09-29" version="1">MFFFFMVCIRRHKNLQWFSINLLTTYLSFDGRIKFKSSTVVRDEMHVMSRNYLNMFLYQQPGFIFINCRIGAKGIPTKRAGAAAVAVGNKIVVLGGVSVTQKPLDSVEIYDVETNTWTAGESMRESLLGIPAVVYEDQVLVTGGMSADGNPRNYFMSYNLKTNMWKSLPPMPTERYATFAFLIDNQLYITGGRQGKLPVDAFEKYDFSSKTWEKLPNIPSKRVFALYASNNTHIFSVGGLKQKAEEGFSDTLECYDITENAWIVGPSMPTKRGDFAIGMVDGKLVCAGGFALIRGGIDSIHLSLSLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EXC7</accession>
    <name>A0A812EXC7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_79379</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005566">
        <property type="protein sequence ID" value="CAE1330008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EXC7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="301"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="359"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1330008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="414" mass="50922" checksum="1A7E0524F0F57F53" modified="2021-09-29" version="1">MLYFEPSENIFFIYYSSIYSFVFLSHFLSFVRSFVRSFFLSFFLSFFLSFFLSFSSQFLSFFLSFFLSFFLSFFLQSSSQFLSFFSPHIFLPFFFLSSLTTFYFFFSLHMFLSFFLSFFLSFFLSFFLSSFSRFLFFLYLHIFFFLSFFTFSSFLSSFSRFFSFFCLRLFLSFFLSFFLSLACTFSFFLHSSRFLSFFNLLIFLSFFLFSMFCTFSFFLSFFLFLSFFLSFLLSFPSCSYHFLAFEFVFLFSCLYIAFIYFYFFLLFRFFSLTFFSLSFFPSFFLPFLLLFLSVFLSHLSFLSFLVTFFLLNHFLSFFILSFFFLSYSLFSFFFFLFLFLTFFFLNFCLSFFILSRFPFFLPFFLSFFLFVSYVLFCFLSMFLFFHTLFSLPIFFFLSFFLSFFLFFLSFFLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AQN2</accession>
    <name>A0A812AQN2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_4895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000160">
        <property type="protein sequence ID" value="CAE1156714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AQN2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="280"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="410"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="436"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1156714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="477" mass="56321" checksum="03E100EC8BB6FD32" modified="2021-09-29" version="1">MGWVWGHYRESKETLQDKSPSRLSKWRAVKEKKVFSKSLFLPSFSLSFPNFFFPFLSFFLSFFLFIFFLSFLSYFPDFLLSFLPSFLPSLLTYFLPSFLTSFLPSVFIFCLSFLLSLYSSFLFRLPFLFSLLPPFLLFPSFIFFPFLSSFLRSFFYFFAFLPSFLHFFLSSFSLLPFFVPSSIFSSSFLPSFLYFSFFLPSLFPFFIFLSSFSVFLPSFIFLPSFSFLPSFLPSFLPSFLPSFLPSFLLSSFSVFPSFFLAFLPSFSVFLSFFLSNPPFLLFPSFIFLSSFSVFLPSFLLLFFRIPSFLPSFLPSFLPSFLPSVRPSVRPSFLPSFIFSFLSFPFPFPFFISFLSSLFPPFIFLSSFLSSFLFTFFLSSLPPFLPFLFLPFLFPFPFFFFPPILLSFLHFLLFPFSFFFFFLSLLHFLLASFSAYLFFFLFSFFFPCFLLFFVHIFPSFLPSFLPSFLPYHIFFSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ASJ5</accession>
    <name>A0A812ASJ5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_3613</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000109">
        <property type="protein sequence ID" value="CAE1152885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ASJ5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1152885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="213" mass="24274" checksum="8ABF582BF55CBE7C" modified="2021-09-29" version="1">MKTNIYLSIYLSIFGFFPSKSLISFSLLHSFYPISTSVLFISIYLSIYPSIKSFFLLSFLSSSSSSETTLPFSTPAASDSHACPVARDTNFRNNDLPVTRDYYKTRFDINSLCLQLIPEEPLHNHSCVTRRILLLGSPVYRDIPLIELNEAKNKCIFFDLSSFVLDSELVNSARMDKRVIWCIQNIRCHFKISPLSAIISILLQIIKEIAICH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AWH0</accession>
    <name>A0A812AWH0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_7094</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000228">
        <property type="protein sequence ID" value="CAE1161959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AWH0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1161959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="288" mass="35981" checksum="C44E2D12CAC9F327" modified="2021-09-29" version="1">MLYSRKYLKTIPVYCLTLPSFFFIFLLSYFQSFFFFLIQHLLNFCLAISYKSFEFFLSLEFFLSFLSFLSFFLSFFLLSFFLLSFFLLSFFLFFFLSFLSFFLFFLSFFSSFFLFFFLSFLLSFFSSFFSFLLSFLFFFLFFLSVFSHMTFFSLNLFFFLSSFCFSLFSLLLLFLLALSHKFFDFFFHWISFLLSFFHFHFFSIFSFFGIYFFYFILFIYFLSFDHYYFFFLKCYFLHFFLLDFSYYISFLKFIFLYFSLVFLFFLVFFLSFFLFNAFLCLFKIFLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AYD1</accession>
    <name>A0A812AYD1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_7765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000251">
        <property type="protein sequence ID" value="CAE1163717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AYD1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1163717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="214" mass="25033" checksum="C8F16060482D481A" modified="2021-09-29" version="1">MCRSYSSLSIYLPIYVSQPAHIYLSLSLSLSLSLSLLFLFTYFDSLFLSLSLSIYLSIYLSISACPYLSIYRSLSLSLSLSLYIYIYIYIYIYTSIGLVLFIIYLSIYLSIYLSIYYSLFISGCRYLSRALSLSLSIYLSLYIHISLFIYLSIYLSIYLSIYLSIYLICPKLSSPLSQSVHIYVSLFFSIYLSIYLSIYLSIYLYIYIYIYIYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AZ25</accession>
    <name>A0A812AZ25_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_7828</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000254">
        <property type="protein sequence ID" value="CAE1163928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AZ25"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="280"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="344"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="475"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="500"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="531"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1163928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="551" mass="66563" checksum="6AADABAD6CFFD87F" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B094</accession>
    <name>A0A812B094_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_7693</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000247">
        <property type="protein sequence ID" value="CAE1163435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B094"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1163435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="204" mass="23029" checksum="BDCC1E3C80DEA8F1" modified="2021-09-29" version="1">MCSVECLRLHPGLPILFFFTGFDVLFTSAFLCQKNNPTDIKDDVLFKEQEKRDQRHFGCFCLSLREEYESEKEDKDTGKRSLSCQLPTCPLSSGLYIIPYLISISLSLSLSLSLSIYLSISLSISISLSLSLHTILYLSFSVCLSLSPSLSLPLSLSLSVYVSLSLLSSPSKIDFFCCSLLLTFPVFKSRFHHRYSKRFIVPFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B171</accession>
    <name>A0A812B171_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SIPA1L2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SPHA_10898</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000357">
        <property type="protein sequence ID" value="CAE1170042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B171"/>
    <dbReference type="OrthoDB" id="2499658at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051056">
        <property type="term" value="P:regulation of small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11210:FF:000002">
        <property type="entry name" value="Signal-induced proliferation-associated 1-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11210">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035974">
        <property type="entry name" value="Rap/Ran-GAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000331">
        <property type="entry name" value="Rap/Ran_GAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050989">
        <property type="entry name" value="Rap1_Ran_GAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15711">
        <property type="entry name" value="RAP GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15711:SF22">
        <property type="entry name" value="RAP-GAP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21022">
        <property type="entry name" value="Rap-GAP_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02145">
        <property type="entry name" value="Rap_GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111347">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50085">
        <property type="entry name" value="RAPGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rap-GAP" evidence="5">
        <location>
            <begin position="215"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="50"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAE1170042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="865" mass="94670" checksum="2A323F0E8043BF9F" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B1E1</accession>
    <name>A0A812B1E1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_9074</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000291">
        <property type="protein sequence ID" value="CAE1166818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B1E1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="287"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1166818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="306" mass="36004" checksum="F234FB72E797957D" modified="2021-09-29" version="1">MQEKQIEIHALVFISFHRFILSFFLFSLSLSLVLNFVELSFSLFLSLSLYQIYRGLSRFNFVRVYLSINLSIYLSIYLRAINVIHLLSLFTSLVFALSLSSLSLLFSTCLTLTRLRISLYHYLYKNRCLPLRNLLLIPSRHLSFLSFFSLSLSYTYGVYLQQKIYTISLALIFFFFTCPSLLSCKHTCTSLSLYSQTRLFLTFLSFFHFLKRSSSFCFVSRPFFSLLFAVYDCVFIIICLSFFSVLLTFSTFPCVFLQRIFFLNYLSLFLSGFIFFFLPFLHTPTYLHIYLSIYLSVSVQIYLSIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B1G7</accession>
    <name>A0A812B1G7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_9560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000305">
        <property type="protein sequence ID" value="CAE1167726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B1G7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1167726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="375" mass="42742" checksum="9B1EA2AB4C67AA6E" modified="2021-09-29" version="1">MNPTQCTDCSYTHFTPYDCQLLPQSNKSFKFPCVVKNINGCTVFKEYVPPKNLQLNTVSLVSINVYNITYSDSVYYGETYPALNYTISLPNGDMLGYCYAVRVNIWNNETNSGYGGDGICRLFSFNIEKPSKKNIQPAFINHKCFTAVTANNYFLKFTTLPYAAEITYSVIINKSNQIILAVAPVHHRLSISIILGFPVTNKCNNLFYLTSYKTATENVSFSTNNSFVFENLQPGFFRVRVKSSCLPIGQNMESEIILLKNIAESETLFNTKIIWVVLPLLVSLIFLICFCRLWKRKCIDRSHKCVIDLVYAANNKRDVIVAENLKKLMEEEFEWYVNNVPMANTPICSCELPNNDVVLYLTASDMQGRSHQKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B2R4</accession>
    <name>A0A812B2R4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_9010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000290">
        <property type="protein sequence ID" value="CAE1166704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B2R4"/>
    <dbReference type="OrthoDB" id="6250723at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026092">
        <property type="entry name" value="RAI2/SOBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23186:SF4">
        <property type="entry name" value="GH22790P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23186">
        <property type="entry name" value="RETINOIC ACID-INDUCED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15279">
        <property type="entry name" value="SOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="485"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="485"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="510"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1166704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="610" mass="67791" checksum="F84F936083F856D8" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B5J6</accession>
    <name>A0A812B5J6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_10621</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000344">
        <property type="protein sequence ID" value="CAE1169478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B5J6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1169478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="152" mass="17667" checksum="7858A7D03855E997" modified="2021-09-29" version="1">MHKSVADYRSHSLFVLPARSLGQGLFSHNHHRTVASITDTSVQPEAWTGINFSFRCSFGFFFWGGAFFFHHVVFDFQIGAFSCVREKTLSLTNTFSHLQGYREFSVVSSFGIHPAKLCCQHVTVWLIFVNIQFYPISLLFYFYAFCEYRPFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B866</accession>
    <name>A0A812B866_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_13240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000443">
        <property type="protein sequence ID" value="CAE1174740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B866"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1174740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="163" mass="19390" checksum="6934401D46EBF7F1" modified="2021-09-29" version="1">MFIFFNLLSPHFHSFSSFFIHFPAFSFIFQLFHALSSFFIHFPAFSFTFPLFHSLSRFFIHFPAFSFIFLPYTLSLLLSLSFSFVFSFQLFPSLFLPCFSFCFFLYIFSFLSHSFLCFFSFPFDFISLHFYPIYIYHEPLFLCLILPPLLTTLSLSSALLSTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BAG3</accession>
    <name>A0A812BAG3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_13234</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000443">
        <property type="protein sequence ID" value="CAE1174732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BAG3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1174732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="214" mass="22838" checksum="21DE76F852C89458" modified="2021-09-29" version="1">MISLKTYQNNSLIDRNQPKYIAEHTSSHSLSHTTMLPIIPSLILMIPYSMLPIPSSLPSLSSHPSLPPSQFPSLPLSLSSHPFLSLSVPIPPSLSQFPSSSLSLSSHPSLSLSSHPSLSLSVPIPPPLSVLIHGSLHGSSPLSLSPMVPIPPSLSLSLPPVPTLPSLFPLSLLFFLLSSWSSTLSLSLSSLSFCFSLCPWGSILSRIGTNDCYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BCE2</accession>
    <name>A0A812BCE2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_14145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000480">
        <property type="protein sequence ID" value="CAE1176391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BCE2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="408"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="437"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="463"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="492"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="515"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="542"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1176391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="566" mass="68318" checksum="F902191D3EC98000" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BCL5</accession>
    <name>A0A812BCL5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_13198</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000441">
        <property type="protein sequence ID" value="CAE1174629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BCL5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1174629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="250" mass="28693" checksum="69F65A7511F01EE3" modified="2021-09-29" version="1">MTSTIGSRLSFPFFPFSFSFLFFFSLFHNLNPKLCKGVFFPQPLFISRFISSFALLFSFFFLSGNLSVTLLRNFAFITISFQLFLTLFLLSFLTPFALLYSSSWCLIMSLSFSLFLFCVLSFLLLLLILCLLLSNFIPLFPTFSFFLSSFYVLLLQPLSSFFRRLSFSFAIPVILSLVLSLSLPLSLLIYFFPICQAERKTITLIKVIRWTLPQVQITVVRLTILKIVSLRVANKIVCVLSKADSRLSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BE52</accession>
    <name>A0A812BE52_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Helitron helicase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_15716</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000549">
        <property type="protein sequence ID" value="CAE1225444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BE52"/>
    <dbReference type="OrthoDB" id="6129494at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786:SF74">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786">
        <property type="entry name" value="DNA BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helitron helicase-like" evidence="1">
        <location>
            <begin position="2"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1225444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="206" mass="24182" checksum="9A511B32D03B6AF6" modified="2021-09-29" version="1">MESEGLGFIKLNQSKLRTDSYIHLHDGLRSDGDPRNLGKPCILPSSYTGGPRYLHERTQDAMTYVHHYRRPDLFVTFTSNLKWVEITRELFPGQQYSHRPDLNARVFRLQLRKLMDLILKGQVFGRVKCHMYTVEWQKRGLPHAHILLWLNDKIDANKIDDFISAETPDPALDPALHEIIKNNMWRELRKKVMLVKRPHLRKGLPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BE78</accession>
    <name>A0A812BE78_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_15199</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000527">
        <property type="protein sequence ID" value="CAE1178423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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    <sequence length="347" mass="39296" checksum="C795A566AE7F98C0" modified="2021-09-29" version="1">MLVTQQNRDRYNGKLPYPFPILPHTRLPLSHTPPLFHATLSHAATLSHATTLSLTPPLSLSLSCHSLALSICPSPSMCICDLLNIFTFLFFPFLSVSIYFILCFKIFSLSIAFILHTPLSLSLSLSLSLSCSLFLYLSCSLSLISFSEFLSKKEREKKKKEKMTFLSLLSSYPPLTLLSSHSPLLSLSSPLTISSALSLTHSLSLYFYFYVSFFLFLSRFFFLFLSVYVFFLYFALSFSLSFPRSLSLSLRFLEYILYLCLSLSISFFVSFYFFLSFPPSTFFLSPPFRVSITLANIVISQFSSSHLSQQILLSTIYGGNYHKLIRAGAIQHLSFFITMATSQIHVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BLJ4</accession>
    <name>A0A812BLJ4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_22716</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000842">
        <property type="protein sequence ID" value="CAE1241234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BLJ4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1241234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="221" mass="25700" checksum="F467D23EC5C31D00" modified="2021-09-29" version="1">MSASMEITQFCNLSPFGEQEKTANFTVFLFSFLLLSAFTQPLSLNFLSQCSSRFPLHIYLSIYLDPPISIYIYLSIYLSIYLSRAHTYLSIYLSIYLYIYLGLSIYLSIYLSIYLIYLSIYLIYLSIYLSIYLSIYLSAQLYLSIYLSLAHIIIYLSIYLSIYLSIYLSRPTHICLSFYVLILLISIYLSIYLSIYLSIYLLFFSSFTPCCYGLGCLESSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BM36</accession>
    <name>A0A812BM36_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_23022</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000852">
        <property type="protein sequence ID" value="CAE1241839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BM36"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
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            <end position="35"/>
        </location>
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        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1241839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="243" mass="29328" checksum="460023444BE5FA7C" modified="2021-09-29" version="1">MVTTTISIHLSIYLSIYLSIYLSIYLSIYLSIYLFIYQTTYLFSSIYLFFINNLFAFDNVFSSIYLSIYLSIYLSIYLCSFNNLFTFINLVYFVYQANYMSILLCLYIRFSTYLSIFCFLSIYLSIYLSIYLFSFIYISIYLITKNQAIYFPFSIYLSIYLSIYLSIYLHLYFHIILDKHGIIIIQHKMWIVPQHINLYSIIYLSIYLSIYLSIYLLAFQIYLSIYLSIYLSMYFPLFIYLCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BQB0</accession>
    <name>A0A812BQB0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_21985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000811">
        <property type="protein sequence ID" value="CAE1239808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BQB0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="335"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="371"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="415"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="444"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="469"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1239808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="502" mass="56934" checksum="F2B1672B8FB3CEB7" modified="2021-09-29" version="1">MSLRPLPFFVSSTSPFLCLFDLSLSLSLRPLPFFVSSTSPFLCLFDLSLSLSLDLSFLCLLTSPFLCLFDLSFLCLFDLSPFFVSSTSPFLCLFDLSLSLSLRPLPFFVSSTSPFLCLFDLSLSLSLRPLPFFVSSTSPFLCLFDLSLSLSLRPLPFFVSFSLSLSLSRFHSLSLSLSRFHSLSLSLSRFHSLSLSLSRFHSLSLSLFLVSFSLSLSLSRFHSLSLSLFLGFILSLSLSLSLSLSFLSSLSLSLSRFHSLSLLSLSHFSLSLCLLSLTLSSLSLSLSPSLSLSFFFLYQFRSQHPSLCYFFLFSINLALTFSLSILFFYQFSFHLLFLLSFNLALNFSLISSLSINLFLTFSLFLSLSIYLSASLFLLFLLTFSLSFLLFLSIYLSPSLLFLISINLERSPFLSSYFFSFYQFSSPLVFLLSYLSSFYQFSSHLFSLLFLLLSLYSLSLYYFYTSFLNSFFTIFLCHLSFYSSSGSPLFPRLFFLCHPFFPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BRF6</accession>
    <name>A0A812BRF6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_20348</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000746">
        <property type="protein sequence ID" value="CAE1236615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BRF6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
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            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
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            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="265"/>
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    </feature>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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    </feature>
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    </feature>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="397"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="421"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="453"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="483"/>
            <end position="509"/>
        </location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        </location>
    </feature>
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        <location>
            <begin position="686"/>
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        </location>
    </feature>
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            <begin position="714"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="767"/>
            <end position="785"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1236615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="802" mass="92010" checksum="70080CC8FC688D93" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BU87</accession>
    <name>A0A812BU87_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_22257</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000822">
        <property type="protein sequence ID" value="CAE1240315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BU87"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1240315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="201" mass="24179" checksum="B44FE30CAF9FE2F6" modified="2021-09-29" version="1">MYRRRSVRNRSVLLSFCFGVSSTRDLAKGENGVFSSKRHSCRGLSNEKSNNTFIEIINSIYLSIYIIFIYYFSLSIYLYYFYLLFFSIYLSIYLSIYLSIYLNFCIYQLFSLTIYLFLYLSIIIFLIFLLLFFLYLSIYLSIYINFSIYQLFSLPIYLLSIYLSIYLVLSIYLIILSIYLFFIYLSIFIYLSIYLSIYLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BV50</accession>
    <name>A0A812BV50_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MBD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_27518</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001070">
        <property type="protein sequence ID" value="CAE1251407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BV50"/>
    <dbReference type="OrthoDB" id="61560at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.890.10">
        <property type="entry name" value="Methyl-cpg-binding Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001739">
        <property type="entry name" value="Methyl_CpG_DNA-bd"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50982">
        <property type="entry name" value="MBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MBD" evidence="2">
        <location>
            <begin position="652"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="446"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="509"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1251407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="713" mass="75787" checksum="0BED757A603A8A08" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C0C3</accession>
    <name>A0A812C0C3_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Uracil phosphoribosyltransferase homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SPHA_24910</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPRTase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000939">
        <property type="protein sequence ID" value="CAE1245884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C0C3"/>
    <dbReference type="OrthoDB" id="106623at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000026">
        <property type="entry name" value="Uracil phosphoribosyltransferase homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14681">
        <property type="entry name" value="UPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="9">
        <location>
            <begin position="27"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAE1245884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="221" mass="24816" checksum="AEBFD1AC65486409" modified="2021-09-29" version="1">MEPDVIQIAPYVAKEEDFGPQLITLKSTNNVKELQTYLRDKTTSRSDFIFYADRLIRLVVEEGLNLLPYQKCKVTTPTGHEYQGLKYEKGNCGVSIIRSGEAMEQGLQNCCGPIRIGKILIQSDADTHEARVLYSNFPPEFSSRKVLLMYPIMSTGNTVTKAMNVLKNHEVKEKNVILLNLFCTPRAVKSLISSFPGISIVTTEVHPVAPNHFGQKYFGTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C0S7</accession>
    <name>A0A812C0S7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_25714</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000974">
        <property type="protein sequence ID" value="CAE1247511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C0S7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1247511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="320" mass="38244" checksum="B1CF584D01D1D4FE" modified="2021-09-29" version="1">MQHYFSVCLFHCVNISGFPYLSIYLSIYLSHFCVLYLSLCNIDLTLSISIYLSIYLSIYLSIYVAVSRRECLSRGPVRVQRRKINSLKRRINYKISLITVTLRSFLASFLPSSLLSFFLSFFLSLPVLFTLLSSIPVASFFSFASFLSFSSLPYMFSSLASFHLTFCFFSFFPSFLPISFFPIFHPFFLFYFFLFSLCSLLFSFFYSFYLSFFLFFFSLFFFFIAYNFFFLFFVFLSPFLSLFFFLSIQYFSSFLIVFFFHFLDFSFFFFFFPFFLCFFHSLCLSLFPSPLLSFIFLHISHVLSFQHSVCLLRKKFHFFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C226</accession>
    <name>A0A812C226_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_28435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001113">
        <property type="protein sequence ID" value="CAE1253395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C226"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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</entry>
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        </source>
    </evidence>
    <sequence length="236" mass="28293" checksum="1D992D5A7692565D" modified="2021-09-29" version="1">MRISRCGAKYLRLSFLFLILFFLLSSFFPFPFLLALFFVFLFFFLFFVYILFFDFTVDVTDSPPTGAIIIFMWFNVCHSFSLFCGFISSDFDFYSFFLSFFLSFFDFRFKASSFIYYYFIFLSFIILSFFFYFFFHNFIIFYRSEYDDCPVTVTPSPVDQCKAGSVHRVFSKPDNCAQFYNCSLPRENPRPGYLGDYIDECPYPKLFSERTKKCENFTTVNCGSRKEIKYACKYFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C6G6</accession>
    <name>A0A812C6G6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SOCS5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_29289</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001164">
        <property type="protein sequence ID" value="CAE1254975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C6G6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1254975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="198" mass="23499" checksum="2036AE32C98370AD" modified="2021-09-29" version="1">MLFSSFFYFLSFPVFMSLFFNLSFSFTMIFFSHLHVSLFFISLGLSFSIFLSLLLSFFLFPSSCLFFPIVRSLFFNLSFSFTMSLFFNLFISLFTSLFIAHSIFMFLFSYLSILLTFLSLFFLSLTSYRMSLFSYLYFSLYYLLYLSVPILMSDSLFLYFYVSLFLPFFPFFYSFSLFSICILAVACPDAIYKEKLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C986</accession>
    <name>A0A812C986_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SUPT7L</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_34986</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001502">
        <property type="protein sequence ID" value="CAE1266104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C986"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10068">
        <property type="entry name" value="BONE MARROW PROTEOGLYCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10068:SF14">
        <property type="entry name" value="CELL WALL ADHESIN EAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="132"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="167"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1266104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="298" mass="28906" checksum="76D61DF151A72C84" modified="2021-09-29" version="1">MIPVSLVHASLVAPVALVALTSLVALVALVPRVALVALTSLVALVVMVVLASLVALVALVALTSLVALVALGSPGIPGSPSSPCPSSPGSPGIPGSPSSPGIPGSPSSLGSPDIPGSPDITGSPGSPGSPGIPGRPSSPGSSGIPLALVDLTSRSPVIPGSPGSPGIPGSPSSPSSPGSPRIPGSPGIPSSPGSPRSPGSPGSPSSPSSPGSPRIPGSPGIPSSPGSPRSPGSPGSPGIPGSPSCPGSPRIPAKYLWLKLIKLNSSEPIRVDNKNRNERTSINIYLSIYLSIYLSIYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C9B4</accession>
    <name>A0A812C9B4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_31777</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001313">
        <property type="protein sequence ID" value="CAE1259626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C9B4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1259626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="218" mass="25783" checksum="BB34D25C506F3691" modified="2021-09-29" version="1">MSPTLCFSNKVLISFHYFPLIFFSFFFCICKVLHLLYCAIYLINNCTFEGISKISVLFLFFFVHLPSFLLSSVTSFRVFIIIYRVLYVIFLFAFPCLPIFLAAFSLFTPSRNFPLFSRPLKPTRFATSIFLLFVPIHSHFAPVFSIPPFIRSVFFRSIESFLFVSLFIFFPFFNIRFFFLSFFPPLSLSKYGSIDRFLNLFLFRIFFLSVSYRPSFMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C9J2</accession>
    <name>A0A812C9J2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UvrB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_31861</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001322">
        <property type="protein sequence ID" value="CAE1259826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C9J2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1259826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="309" mass="34745" checksum="D8712F15538007C9" modified="2021-09-29" version="1">MNNIKGNHRIYELVVYFLSSTTASTVHASQKRVTTHRASKSTATIPSASQTTVSTPGTSQTTASHSDDFPSLKDPSDYFPCFPVYSVYCPFFRAHSDRLSSFLVHGDYSPCFQGHTSQTLGTTLLASQTTVTTHRFSQTTANAPQDSQNRATTHIAFRTTVTTLHASQTTMIILRASQITPTIPLLPWLQQIFLVVHNPTICSSYFPDNSDYSSFFPNNTYQSLFFPDHGDYFPCYPDHSDYSSCLQHSDCSLCFPEHSDYSPCFPDHNNYSFSFPDTSDCSSHFPDNKLLLTVLPRHQRLIFTLPRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C9N6</accession>
    <name>A0A812C9N6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_30926</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001250">
        <property type="protein sequence ID" value="CAE1257760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C9N6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1257760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="261" mass="30803" checksum="AC99734F547CFBAE" modified="2021-09-29" version="1">MLIACEHYGLLSFPFFHSFFLSFFLSIYLSIYISIYLSIYLSIYLSIYLSFLVFLSIYLSIYLSIYLSISDPSIYLSIYLSLIVYNLSFYLSIYLSIYLSLILLSIYLSLSIYLSLIVYNLSFYLSIYLSIYLSIYLSIYLSDGRRPAIIVCQHSYLSTYLCSYPSIYPCLIIHNLGFYLSIYLSIYLSIYLSIYLSISPFICIYLSIYEKSMRKLSASIIRYLWIYLFSWLTTYPHALNPDIYLSIYLSIYLSIYLSIYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C9S9</accession>
    <name>A0A812C9S9_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytochrome oxidase subunit I profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SPHA_30944</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001251">
        <property type="protein sequence ID" value="CAE1257802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023616">
        <property type="entry name" value="Cyt_c_oxase-like_su1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50855">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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            <end position="265"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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            <end position="289"/>
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    </feature>
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    </feature>
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    <feature type="transmembrane region" description="Helical" evidence="2">
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            <end position="469"/>
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            <end position="1016"/>
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    </feature>
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            <end position="1079"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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            <end position="1104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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            <end position="1129"/>
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    <feature type="transmembrane region" description="Helical" evidence="2">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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            <end position="1190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1196"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1224"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1257"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1290"/>
            <end position="1316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1322"/>
            <end position="1345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1357"/>
            <end position="1383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1389"/>
            <end position="1406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1413"/>
            <end position="1430"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome oxidase subunit I profile" evidence="3">
        <location>
            <begin position="169"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="10"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAE1257802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1431" mass="170170" checksum="DB26EF5BDAE47247" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CB60</accession>
    <name>A0A812CB60_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_30193</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001213">
        <property type="protein sequence ID" value="CAE1256515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CB60"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1256515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="155" mass="18276" checksum="8D85B3E6A2E55300" modified="2021-09-29" version="1">MTANHPVLSLQTSYLNLWSPGTLAEIVIVNRSRVLNTRYSFYKSFFLSFFLSFFLSFFLIHQLSSSFSFRSQPFLHLNSFSFFLFFFSCFRNDIVWISLLSSLRTLPQINLIQRHINGALTANLKVDFHYRFPQEYSSYTYVKGWPNYICKNAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CBM8</accession>
    <name>A0A812CBM8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_31291</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
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            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
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                <person name="Li R."/>
                <person name="Bekaert M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">Farmed</strain>
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    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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            <begin position="162"/>
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    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="233" mass="26176" checksum="C4B38D3DCB00A5A1" modified="2021-09-29" version="1">MVVGKGGIYPLGLPLPIPAPLPSSFYYHSLLCSLPLLSQNFFKLWNLNPIFAIPDISLHSSSCLFFLASVSSSPFSLLCLFLLFVFLLSSAFSSFLSFSSPLPFPPFCLSPLLCLFLLFVFLLSSAFSSFLSFSSLCLFLLFCLSPLLCLFLLFLFSPLLCLFLLFVFLLSSLFLLFVFLLSSAFSSFLSFSSPLPFLPCLSFFFLFLLPCLSLSLSLSHIFDLFFLFFFYSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CHK2</accession>
    <name>A0A812CHK2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_33731</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
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    <reference evidence="2" key="1">
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            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001414">
        <property type="protein sequence ID" value="CAE1263483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </feature>
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    </feature>
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        <location>
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="446"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="470"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="505"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="536"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="560"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="590"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1263483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="651" mass="74467" checksum="A7D71150ACFD3FC7" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CIT2</accession>
    <name>A0A812CIT2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_39907</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001875">
        <property type="protein sequence ID" value="CAE1276245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CIT2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1276245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="283" mass="31290" checksum="75E4FB8E1BE81496" modified="2021-09-29" version="1">MQFMISKESKLALVFGVYKSLFSFLSISASLIFFSFFLLHNHLSCFFLSFASIDLFVFYPFSFSTVHRIPFVHVILLNNILNICHISSLLSSPPTPSPPLPQSVSSSPPLCLLLPKLSHPSLCLPHCLLPPTLSTPPPLCLLLSPIRLPTLSTPHPLCLCPYCLPPPTVSSPTVSPPPLCLILPLCLHPHCLLLPPLSPPPPLCLIPHSVSPHCLLPPLSPPPLCLLPPFCLLPSNSLKSLLFNFSTSFSALVFFVFPLFCNRITFRPFSFLPRYSCLFFILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CIY5</accession>
    <name>A0A812CIY5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_35687</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001546">
        <property type="protein sequence ID" value="CAE1267626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CIY5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1267626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="275" mass="34207" checksum="B5C9D499284E971E" modified="2021-09-29" version="1">MYNYARVFFFFNSISLSFFIHLFLSFFFLTFFNIFFFLSISFALSIFFSIFLEHFHFSPSHLFLHFFFSFFHSFHFRSVFFLFIFTHLFLLSFIYSFFHFSFFHLLILFTSFFLSFFNIFIFSLFSFLHIFIFFIIFHLFISFFLFLIFFIFHFFQISIFIYFLFNIFLFFIFNFLSFNFFNFSILFHLFLFFLILSFFLFVFSSFSLVLFSFLFLFFSLSFCFLSFTLCFNFNLFLCSHYFFGTLSFIHSLHFILLFLILSLFPFFHSFSLYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CKL8</accession>
    <name>A0A812CKL8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_36599</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001603">
        <property type="protein sequence ID" value="CAE1269455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CKL8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1269455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="343" mass="38622" checksum="765380A1CAF4C853" modified="2021-09-29" version="1">MYRRSPAVVAVRLLGLAFIAISRNQERNKQPFLRSILIYHHFFYVSPHYSLFFLFSLSFLFSLSFLFSLSFLFSLSFLFSLSFFPHFSLVSFSPHLSLVFFLLTSLWFLFPPTSLWFLFPHLSLVSFFPPPLSGFFFPPPLSGFFHPPTSLWFLSPPHPLWFLSPPQPLSGFFHPQPLSGFFLSTSQKPPQPLSGFFCPPQPLSGFFPPPNLSLVLFSPPPTSLWFLLSPQPLSGFFFPPQPLSPHTHPPTSLWFFLSPQPLSSFAPPPTFFCPPTSLWLFCPPPTSLSVSFVPPNLSLVFPPPLVCPPPLSGFFVPPLSLVSFVPPPLSLVSFCPPHLSLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CN49</accession>
    <name>A0A812CN49_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_41889</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002024">
        <property type="protein sequence ID" value="CAE1279744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CN49"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1279744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="215" mass="25401" checksum="E1272198C13FF93D" modified="2021-09-29" version="1">MSSYSFTSSSYKFSFLFQISSSSSFKFSSFSFKSFLSSLSSSSSSKFSSSFSFYSSMSPYPCPSFFKVFFSFFLILLLLFFFFFFFFFFFFFFFFFFFFIKVTSSFFFFPISAFHRILSSFFFFFHFIFFSLTVTPRLSLSFSLFCFLNISFLFIGGYSLPPDIYITAFFFPIRLFPNTHKTSGLVPSGWHRLQQCLMTFRKSSNKFSPQPCDTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CPX7</accession>
    <name>A0A812CPX7_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondria-eating protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Spermatogenesis-associated protein 18</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SPHA_39634</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MIEAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001856">
        <property type="protein sequence ID" value="CAE1275727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CPX7"/>
    <dbReference type="OrthoDB" id="6105707at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035694">
        <property type="term" value="P:mitochondrial protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035695">
        <property type="term" value="P:mitophagy by internal vacuole formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026169">
        <property type="entry name" value="MIEAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031981">
        <property type="entry name" value="MIEAP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21771">
        <property type="entry name" value="MITOCHONDRIA-EATING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16026">
        <property type="entry name" value="MIEAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mitochondria-eating protein C-terminal" evidence="14">
        <location>
            <begin position="216"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="85"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF16026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAE1275727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="426" mass="48387" checksum="99109180F1DEF7A4" modified="2021-09-29" version="1">MCESSKKDLVSDAKSFLDSLGNVFVLKKRDAQSRHLLSQAKTLIEALLAENQRLSSGGGTPRIGRSGGSMGQLWVKLDEMKRENEELKRQLGKSHEERPVTGKSQGPGEVIISELHKSKTENSSLRAELEKVQKTVQEMHTINTNLQDEYKRLKISLDAANRSLENSRREYKSMETNLNTAKSENEALRQRLCSSPAKAVIRRDNRQFENINERCRPSVIAMKYDTLESQEWVDAKESLEDTTNRDEEEIVKFLCFMLMKTFEASQSVYDKLQSTVSVLLKHPTLAESVGQNGLPPVKQGLTDDLRDGILMALRQNFDEIETSAFVKIAVALAQKSGEFPYFVSSCLENKTLSRYLHECARVTWQMVIQTPAMCLTTNDTVFNVDRHRLWWSCDKGEKSNINFFVWPALYDYEEGALMVKGCVHAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CS74</accession>
    <name>A0A812CS74_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zinc finger protein 367</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SPHA_40730</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001935">
        <property type="protein sequence ID" value="CAE1277614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CS74"/>
    <dbReference type="OrthoDB" id="3437960at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000007">
        <property type="entry name" value="Basic krueppel-like factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF130">
        <property type="entry name" value="ZINC FINGER PROTEIN 367"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="122"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="49"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAE1277614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="309" mass="34446" checksum="12DDA50512B64936" modified="2021-09-29" version="1">MPQLTRAGLILNVGPWSVGLSPSDHYDQIQNNQPQQQISFKFSLGSSDKIGNNVQSKKYGRDTDGEDSNVRRGRPRADSITSLILQGSSSASQIRCQLCRRVFPREKSLQAHLRTHTGEKPYHCNYPGCNRSFCQSGQLRTHLRRHTGEKPFQCPIQGCNSRFAHANRHCSEHPYFSLFFNFYFLYLFKLFLNQSLFSHYFSPSSPCLSPSSPCLSPSSPCLSPSSPCLSPSSPCLSPPPYSHFPQAFVVSLSLSLSLSLSLSLSLHLRTVSVYNDLSLSLSLSLSLSLSLSLPSLPYCQKRSSILSRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CTF9</accession>
    <name>A0A812CTF9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_39691</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001861">
        <property type="protein sequence ID" value="CAE1275860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CTF9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1275860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="200" mass="23093" checksum="CE26C5F2248F5479" modified="2021-09-29" version="1">MPVHCMSFCWSRASFRTDLSIYLSIYLSIYLSIYVSPHINQGVYAHKFLHPHMLSELLTFRTFPLSHHASCCDIVGLICDKLSPTLINTSVVHFFPADRIFHPRFHKFNDKCEAISRLVQGAPNQRNVNHEIKQISLHDDFSSNLEVDIMRSSANSLNRVNLSIYLSVYLSISVCPYLSIYLSIYLSIYLSVCLFIYKYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CUB5</accession>
    <name>A0A812CUB5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_40079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001888">
        <property type="protein sequence ID" value="CAE1276528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CUB5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1276528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="273" mass="32813" checksum="2DBA41B4470B5E14" modified="2021-09-29" version="1">MLFNIFTHPQFSIVTEGLLTDPDPNLSASSRLCLYPMTFVNLQESLTICRWRVCPKLTNELRQPSAPNLHTGDVIVGCAYFFQSLPLNVYVFFVIFFFVFFFFVLLVSFFQTTFLSFFPLFNTFFLKNFKLLFHDIRFFFILFYSFNVLIILFFLSFVTLLHYPFFFSFFLFVFLCFRHVYSSSILFFFLFFLSFFFSFLFLSSFIRSFVCCFSSFIPFFLSSFKTFLFMSCSFFLSFFLSFFPFLHPPNLQPSRSNQFFFFFRKIFSLLFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CUY4</accession>
    <name>A0A812CUY4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_42057</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002035">
        <property type="protein sequence ID" value="CAE1279941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CUY4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23304:SF189">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23304">
        <property type="entry name" value="SPOT2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="400"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="428"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="456"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="490"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="520"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="549"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="586"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1279941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="627" mass="75081" checksum="B80DA80278FC4881" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CWS3</accession>
    <name>A0A812CWS3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_41321</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001979">
        <property type="protein sequence ID" value="CAE1278462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CWS3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1278462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="321" mass="38772" checksum="5ADE2E8937E59E7D" modified="2021-09-29" version="1">MFQSILACSYLSIYLSIYLSIYLSIYLSQSVPIYLSQSVPIYLSIYLSIYLSISICSSLFIYLSQPVHIYLSIYLSIYLSIYLSISVRFYLYLSYRSFVFLSFFLSFFHSSHLFLFFPFPFSFHIFLLYFSHSFFFYMFFFPSFLHFPLHFFLFFLLILFSFSFSSYFLFFLASCFIFHVFLFFCFYFHLVSLILLSTFGLFYFIFFILYFSSLKSLFCDLHYSFFLLFRFPSASFSHFLFISLFSLFFIFLNFFLSFLPKKKLSSVYSILFLTYIIFYCFLFHRYLRLFLSLLDLSCPSFSPPFFSSSLLPCHYLITNFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CX78</accession>
    <name>A0A812CX78_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_42610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002090">
        <property type="protein sequence ID" value="CAE1280920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CX78"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1280920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="343" mass="40605" checksum="46358F707D4177F6" modified="2021-09-29" version="1">MTEFSIHLIIFCLPTAQSIHIYLSIYLSIYLSIYQSLHIYLSIWFRMFASIYLSIYLSIYLSIYLSIWLRLFASIYLSIYLSISVTLYLSIYLSIWFRLFASIYLSIYLYQSLYIYLSIYLSIYLFSLEICIYLSIYLSIYLSIYLSFFIIYLSIYLLFFYSYLSIYLSIYLSIYLSIYHLSNTFLKKKKIPAIKKLSALNNPLKLICRKTKRTNLSIYLSIYLSIYLSIYLFILMFSFLSIYLSIYLSIYLSLTVHIYLSIYLSIYLSIYLFWIILIHLSIYLSIYLSIYLSIYLCCPVSPNPLRIFFAFIFLSRATSCPTASLLSSCFSALSSVEVLQISF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CXM5</accession>
    <name>A0A812CXM5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_42300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002063">
        <property type="protein sequence ID" value="CAE1280396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CXM5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1280396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="164" mass="18237" checksum="7AA852E0D3060E06" modified="2021-09-29" version="1">MQPTVVLEKEYPSVIALDRFSGFARLLRVATFVFKFISRMRGLEADYERKAVIYLKLLQCQAYWIPPPREVVASSGICTSCNSPDVEGESGIDSLPTIFSGTPVNDVQSDTPSGVETMVWPCPVGNVPQGDIGLYLSIYLSIYLSIYKSLLSIYLSIYLSIYLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CY88</accession>
    <name>A0A812CY88_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_43900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002224">
        <property type="protein sequence ID" value="CAE1283146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CY88"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="312"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="355"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="389"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1283146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="428" mass="48144" checksum="DEF96B0C55A533C5" modified="2021-09-29" version="1">MHTFVYLSIYLSIYLSIYLSIYLSIYLSTLYILSCIDYDICCKLSSQPLWVQSKVEEDQIGKIMKGKCNDFLLNLSHSVHIYLSIYLSIYLSIYLSNMFQKLFFFFSFFFFLFLFFVLFSSSSPSFFLSFFLCADVHPDMKERTVYMPAIIVLMRNAVTMECASSGVKVILPDPNVIVVKITIMEINAIILVMAVIMATVTELVSVNKDVIRDTVDKSVRIVKNTIMAISANILVMVVNMATVTELVSVNKDVIRDTAEINVTNVKNTITAISAKILVTAVIMATVTDLVFANKDVIRDIAEKNVINVKNIIMAKSATRIVMVVNMATVTDLVFANKVVIRDIAEISVTNVKNTITVISVTIIVMAVNMATVTELVSANKDVIRDIAEISVTLILFSIVFFFLLLILPFFILSIYLSIYLSIYLSIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CYA5</accession>
    <name>A0A812CYA5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_43940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002224">
        <property type="protein sequence ID" value="CAE1283182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000597762">
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="320" mass="38631" checksum="C80318EB71140DA5" modified="2021-09-29" version="1">MYFFRNMSEKIFAFFFFFFFQMRKEVDLITSSLLFSLFSHSVSFSAFAIFYFSLSSKLSFFTLSAFFRALSHSSIFSSFVSILLFLPLYLLSFISFYFSFFYILLKTYILPTYYSTSFLHISISLLFFSLFLSASATAFSLFQFISIYLSIYLFIYLYTHAFIYFIYSFFSLPLLWRFLSLLNFLFLLFLFMLTSRVHILRFSLSHSFHFLFSFFFRSSFSFSIFLSSLFFFLFLLLYFFLLFFSCSFSLISLFFSFPLSFFLTFFFFLFILLFAVPFFLVLLRSSFLFFFSFHDFFSVHFSFFISVCFFFFLTFSSFSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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                <person name="Bekaert M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
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    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D687</accession>
    <name>A0A812D687_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">SPHA_47288</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
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            <strain evidence="2">Farmed</strain>
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    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    <dbReference type="AlphaFoldDB" id="A0A812D687"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
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    </evidence>
    <sequence length="179" mass="21620" checksum="C0948644BBE07690" modified="2021-09-29" version="1">MRFLVIIPRGMGRRRTIAIKIPVIQSIYLSIYLCSSLSLSTYLCQSVPFAICLSIYLSIYLYIYIFHRFFNFLLMFLFFSFLLLINLPLFLFDFVVDSRSIHSSFFQPFLYIFLPVSLSSFIQFFLLFCPLSYNFLVFKFLLTSFLSSFLTFFLPFFLLFFIYLFVTFHFIYKLYIFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="4">Farmed</strain>
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        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </dbReference>
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        <property type="entry name" value="GRIPAP1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GRIP1-ASSOCIATED PROTEIN 1"/>
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    </dbReference>
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    </feature>
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        </location>
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        <source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="734" mass="85618" checksum="6299D3C35CBE27F6" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D7X9</accession>
    <name>A0A812D7X9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_47752</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002616">
        <property type="protein sequence ID" value="CAE1289628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D7X9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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            <begin position="20"/>
            <end position="47"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="75"/>
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    </feature>
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            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="131"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1289628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="218" mass="25727" checksum="E5C2AEF9E3D4B2FE" modified="2021-09-29" version="1">MHLSQIVSIYHSSIYHMFIIYYLSISVCSSIYLSIYLFIYSYLFIYLIQNVCIYLRLCLSIYLSIYLSIYLSIYLSNSECMHLSQIVSIYLSIYLSIYLSIYLSQSVPIYLSNLSNSECMHLSQIVSIYLSIYLSIYLSIYLSIYLSLLIPIYLCISRSIQIYLSIYLYLYICIILFKSIYLSIIHIYRWIIILSFGLGHVQSADWPSDPMHRNPEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D928</accession>
    <name>A0A812D928_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_49147</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002783">
        <property type="protein sequence ID" value="CAE1292203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D928"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="286"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="452"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="483"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="508"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="534"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1292203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="553" mass="68523" checksum="39292B3290974F1A" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DCK5</accession>
    <name>A0A812DCK5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">SMCHD1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SPHA_49876</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002898">
        <property type="protein sequence ID" value="CAE1293554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10036779at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051276">
        <property type="term" value="P:chromosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058611">
        <property type="entry name" value="Ig_SMCHD1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058612">
        <property type="entry name" value="Ig_SMCHD1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058613">
        <property type="entry name" value="Ig_SMCHD1_4th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058614">
        <property type="entry name" value="Ig_SMCHD1_5th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058615">
        <property type="entry name" value="Ig_SMCHD1_6th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058617">
        <property type="entry name" value="Ig_SMCHD1_7th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058616">
        <property type="entry name" value="Ig_SMCHD1_8th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038892">
        <property type="entry name" value="SMCHD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055109">
        <property type="entry name" value="SMCHD1_S5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22640">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES FLEXIBLE HINGE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22640:SF2">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES FLEXIBLE HINGE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26194">
        <property type="entry name" value="Ig_SMCHD1_1st"/>
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    </dbReference>
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        <property type="entry name" value="Ig_SMCHD1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26196">
        <property type="entry name" value="Ig_SMCHD1_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ig_SMCHD1_5th"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ig_SMCHD1_6th"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SMCHD1_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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            <end position="1824"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        </location>
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    </feature>
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            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="SMCHD1 Ig-like" evidence="3">
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            <end position="814"/>
        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="domain" description="SMCHD1 Ig-like" evidence="9">
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        </location>
    </feature>
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            <end position="1572"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF26194"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF26196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF26197"/>
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    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF26198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF26199"/>
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    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF26201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAE1293554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="2269" mass="263999" checksum="9E1C99C80072C942" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DG53</accession>
    <name>A0A812DG53_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_53546</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003413">
        <property type="protein sequence ID" value="CAE1299952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DG53"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="325"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="395"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="420"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="472"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="496"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="538"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1299952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="569" mass="66837" checksum="0CF43B80648E226E" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DGE7</accession>
    <name>A0A812DGE7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_51362</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003108">
        <property type="protein sequence ID" value="CAE1296242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DGE7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1296242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="251" mass="30842" checksum="F863A8525CD64172" modified="2021-09-29" version="1">MKVANSIITSPFHLSDFKKKILFIIFFPFSLLKVLTLFLFIYLPFLSFLFFVISFFKSLFLPFLPQLSFFLLLILFYSLNYLSLSLSDVILVLFFIFIHYFLFYLQLLFLSFFHFLSVSVYPSLFDTHSLFCFNDFFFLFFLLDYFNIFSFRFIYFIFHFHYIFHFFLLIIFLSLFLLNLFPLIFFLICIHFFLFFLFYHFVSLTFYFSLSLTLFLSLSFLPLPFLFLSLIHTLYSFFFYSFPFLFLLYEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DH49</accession>
    <name>A0A812DH49_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_55556</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003713">
        <property type="protein sequence ID" value="CAE1303438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DH49"/>
    <dbReference type="OrthoDB" id="8963064at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134:SF22">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134">
        <property type="entry name" value="OS08G0543275 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="293"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="327"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1303438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="357" mass="40504" checksum="BF24E6F0AFC7CEA4" modified="2021-09-29" version="1">MIVCLFLSLCSYLPLTDHIYLLIYLSVSSYLPISLSAHIFLSLSLSLSGFISTYPALSLSLFISIYFSLSVHIYLSFFLCSYLPTSVHIYLSLSIYISTYLSLALSSYLSLCSYLPISLCSYIYLPISLCSYIYPSLSVHISTYLSLSVHISTYLSISLFIAIFLPISLSLCSYLPISLCSYIYLPISLCSYIYPLSLCSYIYLPISLCSYIYPLSLCSYIYLPISLCSYIYPYLSLFIYLPTYLSLFIYLPISLSLSIHSYLSTYLSLLTAIFLPITLCSYIYLPISLCSYIYLPIFLCSYIYLLISLCSYIYLSISLSIHSYLPTYLFLFIDINLPISLSPCSYLSSLLSLCQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DHE4</accession>
    <name>A0A812DHE4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_53750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003432">
        <property type="protein sequence ID" value="CAE1300273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DHE4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="310"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1300273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="329" mass="40132" checksum="C0C5954A76FAE8F4" modified="2021-09-29" version="1">MYSYLSIYLCIYLSIYLSIYLSIYLSIYLSVSSIYIYLSIYLSIYLSIYLRTDSVNRLKTGVTLSYIRTHKHPCTRIHLLTGILKYKIQSITNFLSSFLSSFLSFFLSFFLPFFLSFFLSFFLSFFLFFFLSFFLSFFLSFFLLLFLPFFLFIFFLSFFLSFFLSFLYFSCLSFFLVYFLSFYKFSFFLSFFLSFFLILFLSFFLLVYFLFISFLSFFLSFFHSFTFPFSFFLSFFLSFFLSFFYFSFFFLSFFLSFFLSFFLSFFLVYILSFYKLSFFLSHTFLLSFFYLKISFRFFLSFDFPSFLPSFLPSFLPSFLPSFLPFFFIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DJY4</accession>
    <name>A0A812DJY4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_53123</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003358">
        <property type="protein sequence ID" value="CAE1299317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DJY4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1299317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="215" mass="24530" checksum="1715D0A64B1827EE" modified="2021-09-29" version="1">MSIHYLSLYLNLFQIIYIYLRLFIIYLNILQPPYRSISSFSNLSDTFFSYLSLSSVHTGVSMCVSFVICVSLRPFPVFILFSPPPFFKTIPLVLVSLFSPSLSTSPFYLFLLLSSCLLLSLSLSKSLSILFLYPRLPLFSFSYHDSPFLFLFLSPLLPLLFLSLHLPLSLSLTTSPTFSFSIHVSAFLFLSPRLIFTEISVVFLSHFLLSSFIPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DL36</accession>
    <name>A0A812DL36_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SPHA_55547</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003713">
        <property type="protein sequence ID" value="CAE1303428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DL36"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="384"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="438"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="464"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="499"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="532"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="562"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="596"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="652"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="705"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="737"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="769"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="797"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="825"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="857"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="953"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="982"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1024"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1048"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1082"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1116"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1145"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="735"/>
            <end position="1009"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAE1303428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1192" mass="136958" checksum="8EEB42D53803C07B" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DMZ6</accession>
    <name>A0A812DMZ6_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAS1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_56668</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003771">
        <property type="protein sequence ID" value="CAE1303952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DMZ6"/>
    <dbReference type="OrthoDB" id="286301at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050839">
        <property type="term" value="F:cell adhesion molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.180.10:FF:000032">
        <property type="entry name" value="Fasciclin domain-containing protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050904">
        <property type="entry name" value="Adhesion/Biosynth-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900:SF124">
        <property type="entry name" value="FI05614P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900">
        <property type="entry name" value="PERIOSTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAS1" evidence="1">
        <location>
            <begin position="12"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1303952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="153" mass="17500" checksum="93C99133D22D0BF6" modified="2021-09-29" version="1">MHVVDEVLIAPKGNLFMTLKRNPNFTIFSDFLAQTGLDKELENGPYTVFAPGDDAFRKLGNETLQRLHNDQDILEELLKYHIVHGVLWRAGMHSTYLETLVPHDKIFIRKSFFGFLSVENALIISRDIPATNGVIHEIHKVLDIEHLRNNIIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DR58</accession>
    <name>A0A812DR58_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_59845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004146">
        <property type="protein sequence ID" value="CAE1307782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DR58"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1307782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="186" mass="22384" checksum="1CBFD8DD41B36EDB" modified="2021-09-29" version="1">MYSLSVPSFKDQNVTEMVMRSLSLHFYSDQNIARFFIQLFFICFLSFFLSFFLSFFLSFNTLSSFNSHLFVSFSLLPFLFLSLPHLISVLFSLFLFFLFISAFRFFSFFLSFFLSFFLSFNLFSIFNFHLFVFFLFFFLSLFQIRSPSLILISLFYFFLFISLSLLIFVFLSFFLSFFLSFFLSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DSV3</accession>
    <name>A0A812DSV3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_59735</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004140">
        <property type="protein sequence ID" value="CAE1307700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DSV3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1307700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="249" mass="27603" checksum="ED9AA0C77768CE83" modified="2021-09-29" version="1">MTSAIHYSTIPQLSITPPCLSYPLLHHDSAIHYSTMTAITHHPIHYSTIPSAIHYSTMPQLSITHHDSAIHYSTMPQLSITLPYQPSITPPCPSAIHYSTMAQLSITPPCRSYPLPTMTSAIHYSTMTTSMTHPSKPSIHYSTMTQLSITLPCPQLSITPPCLSYPLLHHDSAIHYSTMPQLSIHIHTPCLSYPYPPCLSYPLLHHASAIHYSTMTQLSITPPCLSYPLLHHASAIHYSTMPQLSITPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DV48</accession>
    <name>A0A812DV48_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_62000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004396">
        <property type="protein sequence ID" value="CAE1310431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DV48"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1310431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="157" mass="18629" checksum="71B3DE8C1D2C1590" modified="2021-09-29" version="1">MSPQHLSIYLSIYLSIYLSIYLSIYLSIYELRNFLRLYNQHVREYNYLPCTGILFNLMKIATSLTMYVLNLSIYLSIYLSIYLSICKRRRQSKESRSSIHPSLLISIYLSIYLSIYLSIYLSIYLSQPVHIYLSIYLSIYLSIYLSISIYLNLFISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DV69</accession>
    <name>A0A812DV69_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_60954</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004269">
        <property type="protein sequence ID" value="CAE1309161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DV69"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1309161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="266" mass="31387" checksum="44AC10A695763EB4" modified="2021-09-29" version="1">MLENLIKLNKSVLFFQFFSYIFIARYVFHSKFLFRFFLSFLFSFSHSVSHFFLSSSLNNSSFFLFSFFLSFFLSLFFDMFHLSFSLTFILCFFVSFFLFTLPLSVYFFMSVYIFLHFLLFFKFSFSIYIRFHPISLSLSLSLCVSFSELISFSFLFRLRANEPKVLLIFSFFVPLRLRQEPLCTNSDFFQRGAQPFNSSYLRIVLRDRNTTVRIKIHNVADSGGTSSSPGEDQVVYFLARNTGETGQSLFYLSIYLSIYLSIWSDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DWS1</accession>
    <name>A0A812DWS1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_63816</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004581">
        <property type="protein sequence ID" value="CAE1312598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DWS1"/>
    <dbReference type="OrthoDB" id="10681141at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1312598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="479" mass="55756" checksum="015FB2CA76E3427F" modified="2021-09-29" version="1">MNESIYLSIYLSIYLSIYLSLSVIMYVCMYVCIYISLSIIYLSIYLSIYLSIYLCRLCMYVSIYLYIYLYFSVDYLSIYLSIYLSIYLSIYLSIYLSISVRYVCMYLSIYLYLSIYLSIYLSIFLCRLLSIYLSIYLSIYLSIYLSLSIIIYLSIYLSIYLSRLFSIYLSIYLSIYLFIYLSIAVGYFLSIYLSIYLSIYLSIYLSISVGYFLSIYLSIYLSIYLSIYSDLLCSFPIKARLLVTIQAALLIYEQVHLSVSKNVHLFFSEQVHLFLLNKLICSLPDNTVCSLPSKHVCSFPNKSVSSFPSKPLFSFPSRHLCSFSSKPICSFPSKLFCSFPSKPVCSILSKTSLHFSEQARLFLSEQARQFLSEQAGLFLSEQAGLFLSEQARLFLSEQARLFLSEQARLFLSEQARLFLSEQARLFLYEQARLFLSEQARLFLSEQARQFFSKQARLLVFEQALLLASKQDRLLDSLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DXH4</accession>
    <name>A0A812DXH4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_60339</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004191">
        <property type="protein sequence ID" value="CAE1308448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DXH4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="297"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="476"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="509"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="544"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1308448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="563" mass="65789" checksum="E9C84FA273DBD648" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DYH8</accession>
    <name>A0A812DYH8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_64827</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004677">
        <property type="protein sequence ID" value="CAE1313784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DYH8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="291"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1313784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="317" mass="37777" checksum="70B3B34138B3CB65" modified="2021-09-29" version="1">MKNPTRRSSLGTLCYSFLSRHPVPCVSIIFLFPSIIFYSSTPFFISFPLYLYLSPLSFPSFFFFLSFFLFSSFFLYFSFLWFLLSFFLYFYLSSFFFFFLFSSFCLSSSKDDLHFFFLHFSSRINNSELRHLSSNQRYFLSEFFFHGINYCYRNSRKVGFSQPMINSRTYAHTHILSIYLSIYLSIYLSIYLSIFFSFTNAQSKLISIKKNCIIARRVAICFNEDNNPNDINTVNTSLSLSLSLSIYLSIYLSICNINHSDSIYLSIYLSIYLSMTFQICVYEYFPLYLQMFIFISIHYIYHSILFTHHLSFFIILF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DYX7</accession>
    <name>A0A812DYX7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">GRPE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SPHA_62858</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Farmed</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the GrpE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004498">
        <property type="protein sequence ID" value="CAE1311449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DYX7"/>
    <dbReference type="OrthoDB" id="201635at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00446">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.22.10:FF:000002">
        <property type="entry name" value="GrpE protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.20.20:FF:000003">
        <property type="entry name" value="GrpE protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.22.10">
        <property type="entry name" value="Head domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01151">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000740">
        <property type="entry name" value="GrpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013805">
        <property type="entry name" value="GrpE_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009012">
        <property type="entry name" value="GrpE_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237">
        <property type="entry name" value="GRPE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237:SF23">
        <property type="entry name" value="GRPE PROTEIN HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01025">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00773">
        <property type="entry name" value="GRPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58014">
        <property type="entry name" value="Coiled-coil domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51064">
        <property type="entry name" value="Head domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00045572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAE1311449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="219" mass="24827" checksum="D62A501A29923289" modified="2021-09-29" version="1">MALSNLLFRRRPAMIAVCRFCLGSVKNFRTTRLLSTATEINKTEQDKASTKTEEESSDPKVWAEEKEKLTKDLKSMKDKYLLALADTENVRMRMNKQISDAKLFSIQGFCRDLFEVADILTKATESVPSEELSKNEHLKNLFEGLTMTESQLQKVFNKHGVEKIVPNVGDKFDPYLHEAMFEVPTDSNESGTVAVLTKFGYKLHQRTVRPAVVGVFKGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DZ00</accession>
    <name>A0A812DZ00_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_63200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004531">
        <property type="protein sequence ID" value="CAE1311843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DZ00"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1311843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="157" mass="17790" checksum="EC0C6D55E8CC199D" modified="2021-09-29" version="1">MSSFFYNIFLYLSFPHSISLTLSLNLTRSLSINLSLSFPLCLSLNFPLSLPIYISLSLYFLLPLSLSFFLPQFLSLSLCLTHFVFLFIFLSLNFSLCLYTSLSLSLSISLSLSHSLSLSLSFSFYLSLSFFLFLSLLLSFYLSSSLSSFLSFSLIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E0F5</accession>
    <name>A0A812E0F5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_63296</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004539">
        <property type="protein sequence ID" value="CAE1311956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E0F5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="281"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="319"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1311956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="342" mass="42167" checksum="A171AF69DF5B4485" modified="2021-09-29" version="1">MSSQLVFRWKEYFFLSFISFFLSFFIHLFLFHVCFSFSAHNFLHLFLLIFLFPSIFTLRIRFSFFLSFFLSFFLFLSCFFLAFFFPFSFFLSLFLFLSRSLSHLRIKLSFFLSFFLSFFLSFFLSFFLCSFASYAFILSFFFLSFCLSFFFFLYHPFVFPLRIQLSFIEFFHSFFYPSFSGNNFSFLLFLFLFFFHFFFFFHSFEGTFFVYSFFLSLFLFLFPLILSEKNFLSFFLSLKPSTLLLRPPFHNIFFLSFFLSFFLSFFLSLKPSTLLLRPPFHNIFFLSFFLSFFLSFFLSFFLFLFHLSFSDRTFFLSFLFLYSLFFFFHFFLFFFSFPAFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E213</accession>
    <name>A0A812E213_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_64984</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004679">
        <property type="protein sequence ID" value="CAE1313929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E213"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
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            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1313929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="268" mass="31224" checksum="050778187772A958" modified="2021-09-29" version="1">MPRIHTPVSYTGGLVDHIFYLPIWTECVRKFFSLPAFLIYLSIYLSIYLSIYLSIYLSISFSLSFVPIYLSIYLSIYLSIYLSIYLSQSFHHLLTTLPSLSIYLSIYLSIYLSIYLSIYLSECNSKIILILCLSFISSHHLLNSIVYIYLSIYLSIYLSFHVNESIYLSIYLSIYLSIYLSLYAIYLSIYLSIYLMNSPHKSISFISLCLLIYLSQSVNIYLSFYLSLLISIYLSIYLSIYLSIYLSIYLSIQDIIVGEESFVVLILR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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    <name>A0A812E2N4_ACAPH</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
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            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
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    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004764">
        <property type="protein sequence ID" value="CAE1315145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
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    </feature>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="564"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAE1315145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="610" mass="65243" checksum="38CCD788E083E07D" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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    <name>A0A812E3G3_ACAPH</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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                <person name="Bekaert M."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">Farmed</strain>
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    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAE1316699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="316" mass="38338" checksum="FAB0850EB76DB4EC" modified="2021-09-29" version="1">MNSFTKHERLLSLSLSLSLSLSLSLSLPHEYEILDIQFIPFFLSSFFLSFFLSFFLSFHVFILSLNFYLQFLFFFLSFSFFLLLSFPSLSFFLSFTFFSISFFNSLLLFHYLSDSFLYFLHVSPVLAFFLSFFLSFFLSFFLSFLLILSHFLIKYITRIPFFFIGLFFFFVFLHIFFISSFFPLFFFAIFLFWSFFFLSHIILRHFSPLPLFLPLFPLIFCSLFFSFSFAYYIFLFSFFSFISHFLRVFLSFPIVFFLLFFVPFSISHSISSFLFLLSFPVFHFFFYSFIYSVFFFFLFSPFSLFFFLLCYPFFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <organism evidence="2 3">
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        <lineage>
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                <person name="Bekaert M."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
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    </evidence>
    <sequence length="267" mass="32461" checksum="6BF8932278F2F8FC" modified="2021-09-29" version="1">MSFFSIDFHFLFSSFYLSFYFYSCFLFILLIFFVSFFISLVFSIFLVFSFLSLFFLVFSFLSLFYLFFPFLSLVSFFFSLSFSLLSLFPLIFFFIFLLFFIFHFPYLLFLHSFGSFLYFSQCFILLSFFMTFSLFFHSFYFFVLHSYWFFFPFFILFLYFYFTSEYSSLSFGVSSSFIFFSFLLQKHFLLFAICFLFSLIFFLSYFLFSSFSSYIFVSFFISMLSSSTLFSTSLFFFFFFFFFFFLISTIADILQSAQTTFKTGIHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
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    <organism evidence="2 3">
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
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        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1080" mass="124356" checksum="72FC44F54E5DC33B" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E6T4</accession>
    <name>A0A812E6T4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_65824</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004736">
        <property type="protein sequence ID" value="CAE1314813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E6T4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1314813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="187" mass="22490" checksum="3C98B6AB71CD62D3" modified="2021-09-29" version="1">MRQHIYSKIFSFFSLFSFFRFSHFTLFTHFLSFNFLLIFLFSYFSLFSHLTQFSPVSLFSHFPHFSLFFSSFSFFLFSHCSRLSLLSYFLSLFSFFLLSFLSLFFSFLIFLFCFVFVSCIFRLDSSASICTYFFLSFFLSFFLSFFLSKDSSRFLLDALMFIYSIIYLSIYLSISIYLSIYLSIYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E8G4</accession>
    <name>A0A812E8G4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_67594</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004896">
        <property type="protein sequence ID" value="CAE1316940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E8G4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1316940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="182" mass="21466" checksum="19F1147FB6C026D1" modified="2021-09-29" version="1">MSFLFFSYRFFFSSLYFLFPFFLLFAFIFILKSFLLLRSFFTIFFVIYYQLSFSFTHSLNMLLVIFSFFFSPPFLFSSPLITSSPLSPSSVYRIHLSFYLDSQFFVSSCHFTNSIKLRLQTSYTISVNYSAYASKQTNTPVYMRANLSIYLSIYLSERVYMCILFFLHPVLAKKTADAVLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E8Q2</accession>
    <name>A0A812E8Q2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_68145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004949">
        <property type="protein sequence ID" value="CAE1317596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E8Q2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="280"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="341"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="370"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1317596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="394" mass="48016" checksum="DE047B68E84703B6" modified="2021-09-29" version="1">MLIGKYLIVSNIKQANFIFRPTYEQTPRHFRFLTGLLLCLNSLLLSFCPYLVLFFFLLFFLSFFFLLFFTFALSAFFLSIVLSFFLSFFLSFPNLSFFLSFPNLSFFLSFFLSFFLSFFLFQIFLSFPNLSFFLSFFLSFFSKSFFLSFFLSFFLSFSKSFFFSFFLSFFIFFLSFFLFSFFFLSFFLSFPNLPFFSFFLFFLSFFLSFFLSFFLSFFLSFPNLSFFLSFFLSFFLSFFLSFFLSFPNLSFFLSFFLSFFLSFFLSVFLSVYLSISRTSVILYFFLYSSLYSFFLAFCLSFPLSNLFLSLFPLFFSFCLCLFLFFYLYLSFCHFSLCLSFFFFHSLFLWFFLFFFFFFFLSFFFSLHLSFFLFCFLSFFSFFLSVFLLFFVLCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EAP6</accession>
    <name>A0A812EAP6_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit H</fullName>
            <shortName evidence="4">eIF3h</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SPHA_67441</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Farmed</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit H family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004892">
        <property type="protein sequence ID" value="CAE1316794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EAP6"/>
    <dbReference type="OrthoDB" id="10265695at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08065">
        <property type="entry name" value="MPN_eIF3h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000045">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03007">
        <property type="entry name" value="eIF3h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027524">
        <property type="entry name" value="eIF3h"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045810">
        <property type="entry name" value="eIF3h_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19445">
        <property type="entry name" value="eIF3h_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="6">
        <location>
            <begin position="15"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAE1316794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="329" mass="38044" checksum="DE18AA0609890686" modified="2021-09-29" version="1">MATRKSASDSGIQYVQIDGLVVLKIAKHCEEEGAGDFVQGVLLGLVVENRLEITNCFPFPRHTEEEEFDEVQYQMEIFRNLRHVNIDHLHVGWYQSTYFGSFINRPLVESQYNYQHSIEESIVLIYDPIKTTQGFLSLKAYRLTDAMMDFYKEGEFTPESVNKLKLNFENMFTEIPVVIRNSHLVNVLMCELEQKATESEKYQFLDLATSSMLEKNLRQLIECVDDVAADTNKYLTFQKLYQRQQQSKQQHIHKRQQENSARAAKGEPALPEEDINKLFKPLQAPQRLDSMLIAGQIDNYCTQILEFTSQSFGKLFMADSLQAVNAQQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EC12</accession>
    <name>A0A812EC12_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Integrin beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="28" type="ORF">SPHA_68471</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="28">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 22">Cell membrane</location>
            <topology evidence="1 22">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Membrane raft</location>
            <topology evidence="20">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 22">Belongs to the integrin beta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="28">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004982">
        <property type="protein sequence ID" value="CAE1317962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EC12"/>
    <dbReference type="OrthoDB" id="410592at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008305">
        <property type="term" value="C:integrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033627">
        <property type="term" value="P:cell adhesion mediated by integrin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006909">
        <property type="term" value="P:phagocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.100:FF:000002">
        <property type="entry name" value="Integrin beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000036">
        <property type="entry name" value="Integrin beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1240.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.100">
        <property type="entry name" value="Cytochrome c1, transmembrane anchor, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1680.10">
        <property type="entry name" value="ligand-binding face of the semaphorins, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1510">
        <property type="entry name" value="ntegrin, alpha v. Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057073">
        <property type="entry name" value="EGF_integrin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015439">
        <property type="entry name" value="Integrin_b-2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033760">
        <property type="entry name" value="Integrin_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015812">
        <property type="entry name" value="Integrin_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014836">
        <property type="entry name" value="Integrin_bsu_cyt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012896">
        <property type="entry name" value="Integrin_bsu_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036349">
        <property type="entry name" value="Integrin_bsu_tail_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002369">
        <property type="entry name" value="Integrin_bsu_VWA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032695">
        <property type="entry name" value="Integrin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057243">
        <property type="entry name" value="Integrin_I-EGF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016201">
        <property type="entry name" value="PSI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10082">
        <property type="entry name" value="INTEGRIN BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10082:SF60">
        <property type="entry name" value="INTEGRIN BETA-PS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23105">
        <property type="entry name" value="EGF_integrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08725">
        <property type="entry name" value="Integrin_b_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07965">
        <property type="entry name" value="Integrin_B_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00362">
        <property type="entry name" value="Integrin_beta"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17205">
        <property type="entry name" value="PSI_integrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002512">
        <property type="entry name" value="Integrin_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01186">
        <property type="entry name" value="INTEGRINB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00187">
        <property type="entry name" value="INB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01241">
        <property type="entry name" value="Integrin_b_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01242">
        <property type="entry name" value="Integrin_B_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00423">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69687">
        <property type="entry name" value="Integrin beta tail domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69179">
        <property type="entry name" value="Integrin domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103575">
        <property type="entry name" value="Plexin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00243">
        <property type="entry name" value="I_EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="12 22" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="17 21" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="18" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15 22" id="KW-0401">Integrin</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0581">Phagocytosis</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-0873">Pyrrolidone carboxylic acid</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="6 22 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 23" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="701"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="domain" description="PSI" evidence="25">
        <location>
            <begin position="47"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin beta subunit VWA" evidence="24">
        <location>
            <begin position="53"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin beta subunit tail" evidence="27">
        <location>
            <begin position="619"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin beta subunit cytoplasmic" evidence="26">
        <location>
            <begin position="724"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="21">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="21">
        <location>
            <begin position="57"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="21">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="21">
        <location>
            <begin position="212"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="21">
        <location>
            <begin position="377"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="21">
        <location>
            <begin position="408"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="21">
        <location>
            <begin position="435"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="21">
        <location>
            <begin position="460"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="21">
        <location>
            <begin position="465"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="21">
        <location>
            <begin position="476"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="21">
        <location>
            <begin position="505"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="21">
        <location>
            <begin position="507"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="21">
        <location>
            <begin position="512"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="21">
        <location>
            <begin position="530"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="21">
        <location>
            <begin position="551"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="21">
        <location>
            <begin position="553"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="21">
        <location>
            <begin position="558"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="21">
        <location>
            <begin position="569"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="21">
        <location>
            <begin position="591"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="21">
        <location>
            <begin position="593"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="21">
        <location>
            <begin position="598"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="21">
        <location>
            <begin position="612"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="21">
        <location>
            <begin position="619"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="21">
        <location>
            <begin position="625"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="21">
        <location>
            <begin position="645"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00035630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR002512-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU000633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="SMART" id="SM00187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="SMART" id="SM00423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="SMART" id="SM01241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="SMART" id="SM01242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="CAE1317962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="772" mass="85582" checksum="C48ECE6807079077" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EF95</accession>
    <name>A0A812EF95_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ESF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_72563</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005331">
        <property type="protein sequence ID" value="CAE1322588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EF95"/>
    <dbReference type="OrthoDB" id="287393at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034462">
        <property type="term" value="P:small-subunit processome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039119">
        <property type="entry name" value="ABT1/Esf2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12311">
        <property type="entry name" value="ACTIVATOR OF BASAL TRANSCRIPTION 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12311:SF7">
        <property type="entry name" value="ACTIVATOR OF BASAL TRANSCRIPTION 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032443559" evidence="2">
        <location>
            <begin position="28"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="329"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1322588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="359" mass="42125" checksum="87C1DA8FF311BDF6" modified="2021-09-29" version="1">MTRGKGIFTPFIIFALHRSLPFKMASADDHEMEDERLSYFGEVGRIYLQADEESRVCKKGRLYKEGWVEFKRKRHAKLAAQMLNGEEVSAKPTAPWAGELWNMKYLPKFLWTHLGERLAYEQAVHKQRLQTELSKAKREANVKNKSQDKQPTTFFSSPFIFSFLSFPFLFCFPFIFSSTFIFSSLFLSSFPLSSFHLFLSSFPLISSFPLSSFPLFLSFHLFLSLPFIFSSIFFSSFPLSSFHLFLSSFPLLSSFPLLSSFPLSSFHLFLSLLFIFSFHLLLYFHLFLSFHLFLSLLFIFSFPLFLSFHLFLSLLFIFSSLFFSSFPFIFCFIFIFSSLFLFSQTFLLTLYFPSFKPYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EHB3</accession>
    <name>A0A812EHB3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_74406</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005429">
        <property type="protein sequence ID" value="CAE1324722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EHB3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="336"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1324722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="365" mass="43388" checksum="3546EE603677DFE1" modified="2021-09-29" version="1">MFFLFWGFFLSFSLIRLSSSHSFFLSFFRVFFLSLRFKFIFLFIYFFLVVLHFFILLPILYISFCILCFPNINFFFFFYSFNSIFSSSLLSFCPSVSQQPFLLSIYLSIHLSSIYLSIYLSSVVYYLYHPSIYLSIYLSILFYPSIYYPSIYPSIYLSIISIYHIYLSIYLSIYPSIHPVVYLSIYLSIYPSILYLFSVVYLSIYLSIYLSIYLSILGSLSIYLSIYLSIYLSIYLSILGSLSIYLSIYLSIYLSIYLSIYLSIYLSSVAYLSIYLSIYPLFILYLVYLSIYLSIYLSIYLSSVVYLSIYLSIYYFPSLITLSNFHFFLSFDFSLLLFLVNLFILFFSFSFVLFFHFFPLLFSQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EHW9</accession>
    <name>A0A812EHW9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_75715</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005470">
        <property type="protein sequence ID" value="CAE1326159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EHW9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1326159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="156" mass="17028" checksum="D58EA807635756E6" modified="2021-09-29" version="1">MFAAELNLEQEFSDITFSLFLSLSPLLSSLLSTSLFLSHSLSLALSPSLFLSLPLSLSLPRSVHRSLPSLFLSPLLFLFLSHSLSASLSPPRSFSLPLSFSLFLFTLSPSPRLFSSLSFSLSFGSTEKDALMTFVYLSLTKRLVLAALCITKLSAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EIG3</accession>
    <name>A0A812EIG3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_76094</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005480">
        <property type="protein sequence ID" value="CAE1326515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EIG3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1326515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="166" mass="19302" checksum="29F659E8678A0831" modified="2021-09-29" version="1">MIHNGLSTKTVDTPATQTLSVSLETIDTTEMLSDETPVGRGRSVQAVFLRSSHTYLSFANDIWFCRPSCIKLFLTLSFLFFFLSFFLSFFLSLFLSFFLPCFFPSFRAFSFLLSFLPLSLIFFQHIFLSVTLLVSLFFSYPLSDSFFLSFFLSFFLSFFLSFFYVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EJB6</accession>
    <name>A0A812EJB6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_76670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005495">
        <property type="protein sequence ID" value="CAE1327097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EJB6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="338"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="374"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1327097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="398" mass="45542" checksum="D456F40083CB031D" modified="2021-09-29" version="1">MNSTIPRFRVVCRCGVVHRQVECEPRPVVPRAPTKRFVYNLFDFFHQLTLSPYLPLSLFSSLSFSFSFSLSLSLSLIHYLRLDRLPCLSSSFSFFFLFRLSHELNLYSPTLLPPSFQVFFSDPPTPSSSRIVSFISSFFPPFIFGKLSSPHSPFLPLLTSAFLLYLVFLLFLFTIFFFSLLVSSLSSFYLFSSLSSFLFSFFCHSLLSSSHSPPSTLPLLFILLRTSFSISSLYSLPLIHFSLPFSSFYSPYSLPFLFPLSILIFLFTSLYFYSPDTLFFHVPLSTLFYSFTLLSLFLFFYSPYPSFSLSSLSLSTLFLSFTYPILFSSFYFQDTLSFLFPPFLSSNLISSFTSLLFVFSFSLQSSFSLSSLPFFLLIHLSPPSFSFPVSFSTGLILP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EJW9</accession>
    <name>A0A812EJW9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_75864</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005475">
        <property type="protein sequence ID" value="CAE1326290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EJW9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1326290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="320" mass="39546" checksum="804CF64F94090268" modified="2021-09-29" version="1">MFAIHYSFLSSFILPFLFCFILSFFLYFSFFIYFSLSSILSFFISFFHFSFSFFHIFFLSFFFLSFFHFLPFIFSFFHYFSLSFFRSLFFFLSVIFSFSSFHIFFFYSFSLSFSRFFFLSFFHFSFFHYFSLSFSRSFFFLSFSRSFFLSFFHFFHFHSFIFSFFHSFSLSFFRRFFLFLISLFHFSSFFLCFFLCFFFSFYYHFFFFQCVLYLSIYLSIYLSIYLICSIYHISLFHLSLSMFYLSIYLSIYLSIYLSSQSVHIYLTLFYLSICSYLSIYLSIYLSISVCSYLSICLSIYLSIYLSIYLSLYIRGLMKKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ELG6</accession>
    <name>A0A812ELG6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_78246</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005532">
        <property type="protein sequence ID" value="CAE1328530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ELG6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1328530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="179" mass="20805" checksum="482ED0B1496051D1" modified="2021-09-29" version="1">MLNVIHSLSVLYSPYPQPSTFKFARNHIFLCFFFYVPCFSFFTPIGVSHLLPTAFFIKLTSSLSVSLKHHIYPRNTTLTISLLNCISLSIYLSIYLSIYLSIYLSIYLSMSRLIYTITAYLSLFVSKFLSFFLSFTVSSYLYYRLLSLLIYLSIYLSIYLSIYLSISPLLIYLSIYLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ENL1</accession>
    <name>A0A812ENL1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_75713</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005470">
        <property type="protein sequence ID" value="CAE1326164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ENL1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1326164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="210" mass="24558" checksum="DA89E528BA63701A" modified="2021-09-29" version="1">MNGSISIYLSIYLSEQKHNISITSDHSKHYRSSLSLSLFLPLTLYIYLCLVTFCFQVSFSVHFSLFISLSLLCIQLSLSLSLFCSLSGYVLFSTLFLLSLLSFFLSFFHQVNLLSFFSMPCFFLQVCLLSFFLSAFLSFNMPFFLVCCLSFFLFFFLSFFFSFFLSFFLIYFLFFSILSFFLIYFLSFSILSFFLSFFLSFFLSVSFAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EQ23</accession>
    <name>A0A812EQ23_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_78825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005552">
        <property type="protein sequence ID" value="CAE1329331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EQ23"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1329331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="184" mass="22006" checksum="3A3B85938545F5FC" modified="2021-09-29" version="1">MLFFEAFPQFILLIYLSIYLSIYLSIYLSIYLLQSVRIYLSIYLSIYLSIYHILFISIYLSIYLSIYLSIYLYIYIIPCSYLSIYHTMFISDILCLYLSMYPSYSVHIYLSIYLSIYLSIYLSIYHTVFISISHTLFISIYISIYLSTYLRACGRVFRKLPFYLSIYLSIYLSIYLSSKFILAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EQD2</accession>
    <name>A0A812EQD2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Zinc metalloproteinase/disintegrin,Zinc metalloproteinase-disintegrin-like bothrojarin-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SPHA_75447</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005459">
        <property type="protein sequence ID" value="CAE1325863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5951731at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006509">
        <property type="term" value="P:membrane protein ectodomain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04269">
        <property type="entry name" value="ZnMc_adamalysin_II_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.70.10:FF:000001">
        <property type="entry name" value="Disintegrin and metalloproteinase domain-containing protein 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.70.10">
        <property type="entry name" value="Disintegrin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006586">
        <property type="entry name" value="ADAM_Cys-rich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001762">
        <property type="entry name" value="Disintegrin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036436">
        <property type="entry name" value="Disintegrin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013111">
        <property type="entry name" value="EGF_extracell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034027">
        <property type="entry name" value="Reprolysin_adamalysin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905">
        <property type="entry name" value="ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905:SF159">
        <property type="entry name" value="ADAM METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08516">
        <property type="entry name" value="ADAM_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00200">
        <property type="entry name" value="Disintegrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07974">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01421">
        <property type="entry name" value="Reprolysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00608">
        <property type="entry name" value="ACR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00050">
        <property type="entry name" value="DISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57552">
        <property type="entry name" value="Blood coagulation inhibitor (disintegrin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50214">
        <property type="entry name" value="DISINTEGRIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="14" id="KW-0401">Integrin</keyword>
    <keyword evidence="4 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1220"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12B" evidence="13">
        <location>
            <begin position="817"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="domain" description="Disintegrin" evidence="12">
        <location>
            <begin position="929"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="11">
        <location>
            <begin position="1166"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1269"/>
            <end position="1297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1373"/>
            <end position="1417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1455"/>
            <end position="1638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1386"/>
            <end position="1403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1455"/>
            <end position="1471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1519"/>
            <end position="1530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1597"/>
            <end position="1607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1608"/>
            <end position="1638"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="863"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="862"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="866"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="872"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="989"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="1170"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="1188"/>
            <end position="1197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAE1325863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1638" mass="178056" checksum="DABB80D83FB134A8" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EQR4</accession>
    <name>A0A812EQR4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_77204</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005507">
        <property type="protein sequence ID" value="CAE1327764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EQR4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032488845" evidence="2">
        <location>
            <begin position="33"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="317"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="358"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1327764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="426" mass="51916" checksum="A26D281AF07155A6" modified="2021-09-29" version="1">MLAPKLGWRLQIALPRALLSVTLSVCKSKISAENCHFLPFRPLNHKENNLRNRFEYDIYLSIYLYIYLSIYMKKYSFKECLFFLSFCLSFVHSFFLSFFFLSLFVSFPFFFFLYFFFLHSFFLFHSFFFFLSFFLFLSLFFLSFFTHSFIHSFVLSFTFIHSLFLTFILSFILSLFFISFFHSLFLFLSFFFSLFLSFSFFLFSFILSFFIFMSLFFLSFFIHLFIHSFFLFSFFHSFILLSFFLFLSFILSFYFFLSFFFSSNTYTVVGKVCIFYSLSAWVAVLSVGGLDLLFSTITLLTDTVGHFLSRLSKWTSALVYSFFLSFFSFFFLFLFFIHSFFFFQFFFHSLFHSFIHSFFYFLSFSFLLFISFFFLLFFTSFFLFSCKLSFVILRTRSVLLSCLLFTSEREREREREREREREREKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ESI8</accession>
    <name>A0A812ESI8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_80129</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005591">
        <property type="protein sequence ID" value="CAE1330852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ESI8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="244"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="345"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="375"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="410"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="438"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="461"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="498"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="532"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="571"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="606"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="631"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="655"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1330852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="674" mass="78091" checksum="6A838C59430F525D" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812F074</accession>
    <name>A0A812F074_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_80364</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005598">
        <property type="protein sequence ID" value="CAE1331129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812F074"/>
    <dbReference type="OrthoDB" id="6105566at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1331129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="232" mass="26091" checksum="005CE688A845F9DF" modified="2021-09-29" version="1">MNLVFPAICSITKSIYLSIYLSIYLSIYHFFLITPCFSLITPCDQFFSDTKEISAVIFHWSISAASSSICLFNQSTRSPFEAYDVAASPANLKRWGVHESSPCRFCGAYGNLRHILLSCQKVLQNDWYPFRHNLFLEVVTTAARSASIHSTVLRRIAFLKAEDQVGGIEELTFPPSSSSISSPFATNFLLQLSINIQIQPTPPPLHIQLLPLPPYSFSKFNSVLSIIFLYFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ALA0</accession>
    <name>A0A812ALA0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_2513</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000069">
        <property type="protein sequence ID" value="CAE1148590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ALA0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1148590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="244" mass="28833" checksum="98450FD86D23BC3E" modified="2021-09-29" version="1">MMRMLSSFSFIYSLSLSFNYFSSSFSLFLPLFPFFFIYSIFHIIQFPSFLFSILLLIFSSSSIFPSKFSSSSLLIYSLLSSLSFYSLHFYFYFLFHPYSIMLSCQLLLSLSLLSYHIILSTYTFSFILILSVFAFLFSFQLISVCLFPFFLTLSCHTVYFYFLCHHYSFMLTFIFFFIVIISYYTIYLYFLFHPHSNILSHLLLLSLSFLSYHIITSTFTFSFILIFSLLSLSIFTSSFILILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ANQ2</accession>
    <name>A0A812ANQ2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_2392</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000066">
        <property type="protein sequence ID" value="CAE1148278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ANQ2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1148278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="386" mass="46737" checksum="96A0D4DC3CA7FD62" modified="2021-09-29" version="1">MFDKIYLILFIIYLSIYLSIYLSNSLHYLSIDLILFKAAFLSNRISGRPPFYFPIEIAFRSWLNIYFLSFIFHFLSFFLSFFVIFHSLISCLVSSPSCLLLLILFLFFLHSFSFSYSFLLLFKSIQNFFHRVQHFSFSMSTEYLLFHRCTHFFFFFNCICFSSLSHCFSLTIFFFVIIFFVYIFLPFLPYRIFWLHFSSSSSALSLLFFVNSLFFFFFLFVYISSSSFPSLFSFFVFIFVFSFIPFLRCLIFFFLSLRFFFVLFVIVLLTSTSTRKQQHILFLLLFPLLFLLLYRFVLLYQEALFHVFLRQHILTFPVFLCSPFLSLLPVRLSKKFHSFLFFFFSFLFFFFFFFFLSFAPFLSLLSHAIIIPLHLRFFFHLFSLDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ANS7</accession>
    <name>A0A812ANS7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_1868</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000054">
        <property type="protein sequence ID" value="CAE1146624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ANS7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="67"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="317"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        </location>
    </feature>
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        <location>
            <begin position="559"/>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="594"/>
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        </location>
    </feature>
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        <location>
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        <location>
            <begin position="674"/>
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            <begin position="713"/>
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            <begin position="771"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="812"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="879"/>
            <end position="899"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="906"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="958"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="989"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1024"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1050"/>
            <end position="1076"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1146624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1084" mass="127754" checksum="2B7C82F946F4552B" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AQ26</accession>
    <name>A0A812AQ26_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SPHA_2990</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000087">
        <property type="protein sequence ID" value="CAE1150681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AQ26"/>
    <dbReference type="OrthoDB" id="6241467at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032770">
        <property type="entry name" value="DUF4537"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14343:SF5">
        <property type="entry name" value="DUF4537 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14343">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15057">
        <property type="entry name" value="DUF4537"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13768">
        <property type="entry name" value="VWA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="731"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="755"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="784"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="817"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="850"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="881"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="3">
        <location>
            <begin position="36"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4537" evidence="4">
        <location>
            <begin position="314"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="560"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="567"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF15057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAE1150681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="912" mass="105709" checksum="74F6B91E1D49E0D2" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AQ39</accession>
    <name>A0A812AQ39_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_3501</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000105">
        <property type="protein sequence ID" value="CAE1152506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AQ39"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56935">
        <property type="entry name" value="Porins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="392"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1152506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="431" mass="49384" checksum="FCCD319AD52B88B0" modified="2021-09-29" version="1">MYLSVYLSETFCLSIYLSIYLSLFIIYLSVCVLSIYLSIYLSIYLSIYHSLHIYLSILSGRREDPIGEAITPKIGRFGENNNKKRKIIQRDDGYRRNRLPSPGPTLLPDASPRIVHLPESIAAFWDKIWSLAGLHKHSHSDRNSFDFILSESASPHPTLLPRHTFLFLSLSLSFPLLLSSDIQSLSLSLSLSPSPAYTHTRATNARFHSFIHSLSHMYKLTHCVFHTYFLSFSLSLSIYLSLYLSFTLSLSLSLSLSLSHTHTHTHTHRNAYTQAGTQKIFRTENKWDFHLISKTVKSFSLSLSHILIHTENHLFYLSYSQIHAPPSYTVILTLKHILSLSLSLPLTQFYLLFLSHFSNKFSSSFLSHTYLLIIPHPLPLLSLSLFPHRISIYLAIYFSLFTCFSVCSYLSIYLSIYLSISIYLSIYLSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ATQ7</accession>
    <name>A0A812ATQ7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_4090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000126">
        <property type="protein sequence ID" value="CAE1154001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ATQ7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="325"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="438"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="471"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="504"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="559"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="600"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="650"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="681"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="719"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="760"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="795"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="836"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="874"/>
            <end position="895"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1154001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="909" mass="105779" checksum="CDD1C6074CCA5A9B" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AV74</accession>
    <name>A0A812AV74_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">NUP210</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SPHA_6394</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NUP210 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000210">
        <property type="protein sequence ID" value="CAE1160385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6152658at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000298">
        <property type="entry name" value="Cyt_c_oxidase-like_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055096">
        <property type="entry name" value="Ig_NUP210_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055097">
        <property type="entry name" value="Ig_NUP210_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055098">
        <property type="entry name" value="Ig_NUP210_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056897">
        <property type="entry name" value="Ig_NUP210_4th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056898">
        <property type="entry name" value="Ig_NUP210_6th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055099">
        <property type="entry name" value="Ig_NUP210_7th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008964">
        <property type="entry name" value="Invasin/intimin_cell_adhesion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045197">
        <property type="entry name" value="NUP210-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23019:SF0">
        <property type="entry name" value="NUCLEAR PORE MEMBRANE GLYCOPROTEIN 210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23019">
        <property type="entry name" value="NUCLEAR PORE MEMBRANE GLYCOPROTEIN GP210-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22967">
        <property type="entry name" value="Ig_NUP210_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22969">
        <property type="entry name" value="Ig_NUP210_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22963">
        <property type="entry name" value="Ig_NUP210_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24991">
        <property type="entry name" value="Ig_NUP210_4th"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26182">
        <property type="entry name" value="Ig_NUP210_5th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24935">
        <property type="entry name" value="Ig_NUP210_6th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22962">
        <property type="entry name" value="Ig_NUP210_7th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49373">
        <property type="entry name" value="Invasin/intimin cell-adhesion fragments"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50253">
        <property type="entry name" value="COX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="201"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="402"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="449"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="986"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1012"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1041"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1072"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1098"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1127"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1150"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1178"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1215"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1241"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="domain" description="Heme-copper oxidase subunit III family profile" evidence="11">
        <location>
            <begin position="991"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="768"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="770"/>
            <end position="788"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAE1160385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1759" mass="197198" checksum="E57674FC622141E9" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AWY5</accession>
    <name>A0A812AWY5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_8445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000273">
        <property type="protein sequence ID" value="CAE1165406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AWY5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="392"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1165406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="418" mass="46553" checksum="CF93D0037ECDFD32" modified="2021-09-29" version="1">MSKTHADKIRNAHINQPSRESHSAEKLPNQQKRSASLPQAQLTSVRQPQRHTQDDVILPNSPQIKPHQVSSSEYLNHPSPKVSCINSEQNRTETNTEQSEEKNQDVYTTQYCNPQPKQSGQPGQETEMRPLGQTVNYPSDTTIVARGFYTPSLIQNTDNKDSVTEDSNSSDIICIIRCNDQRNVTYAHAMNPPNVVGTPNIGPSGRYMSDQRHLMCPSKQGISWPTAVSKTQADKIRSAHINQPNRESHSVEKLSSQQQRSASLPQSSTTLQILSQRSLNEKPGLPVNTTNKSQAVTSLEYHNQSSPKMLHHSANEHKNEDSSSQGEVMTEVYNSQYCNPQPKQSGQPTQETEMRPLGQTVNYPSDTTIVARGFYTPSLTQNTDNKDSVTEDSTSSDISQQSTGNIYRNPRPLPPVPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B1F2</accession>
    <name>A0A812B1F2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_8132</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000263">
        <property type="protein sequence ID" value="CAE1164754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B1F2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23304:SF189">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23304">
        <property type="entry name" value="SPOT2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1164754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="266" mass="31028" checksum="472B7F84B41A7BF9" modified="2021-09-29" version="1">MYVGICLRLYLSIYLSIYLSIYLSIYLSIYLSDLIHIYLSIYLSIYLSIYLSIYLTSIYIYMSVHMYVCMYLSITVCPYLSNFVSIYLSIYLSIYLSIYLSISLSRLYLSIYLSIYLSIYLSIYLSISRFTIKSGSNVSHWLNNPLPHSAILSPNFFLSFFLSFFLSFFLSFFSPVFLSFFLSFFLSFFLRKPFHGAWINSVRLISASRRCLSLGQDVSSSISLMKSMFVRAIFAIAVSKQLATLVCHGKYFFFFFGTSTYLQHRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B1Q6</accession>
    <name>A0A812B1Q6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_9494</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000302">
        <property type="protein sequence ID" value="CAE1167503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B1Q6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1167503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="195" mass="23264" checksum="9F1A8150084CD43C" modified="2021-09-29" version="1">MDVDKKIVSLLTSTILLREIWESPYVPQANSKTGEGQDKLYPVVPCFSLFSRVTKIIDSFTFYLFSSFVPFFVFLIICVCFFSFLLFFFIICLFFFLPLFLSFFFFFICFLFLSLIHQPFSFYLFSSFFLLHDFFLYVFFSYFNVVYCLSLIFPPPPLLLLLLLDTAIIFLSFYLLFSFRFFFSSSIFTSYNLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B2A0</accession>
    <name>A0A812B2A0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_7943</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000257">
        <property type="protein sequence ID" value="CAE1164237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B2A0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="295"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="324"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="358"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="413"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1164237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="433" mass="51588" checksum="40CAE88BA5F7E2E1" modified="2021-09-29" version="1">MEIRYVLSLSHSIVQESKKREFIFLLINKQNCSLFECFCTSIYLSIYLSIYLSNISFYLSIIYLSIHSFIYLSIYLSIPFSFYLSIYLSIYLSIYLSIYTILILSIYLSIYLSIYLSIYLSIPFSFYLSIYLSIYLSIYPILILSIYLFIHLSIYLSIPFSIHLSIYLSIYLSIYPIHHSIIHLSIYSFIYLSIYLSIYPIYHYHLSIYLSIYLSIYLSILLSIHLSIYLFIYLSIYPILILSISSIYLSIYLSIYLSIYLSISFTNFFIYLCTYILGVNLLNINIYLSHSHSIYLSIYLSIYLSIYLSIYLSIYLSFSFIHSIYLSIYLSIYLSIYSIYFIHFLYLSMFIYTGSFSAYLSIYLSIYLSMYLSILFSFYLSIYLSIYLSHFHFIYLTIYTILNLSNYLSHVQFIYLSIYLSIYLSIYLSNKFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B2P5</accession>
    <name>A0A812B2P5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_11776</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000391">
        <property type="protein sequence ID" value="CAE1171805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B2P5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1171805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="224" mass="27709" checksum="9D4AB67B339C28E6" modified="2021-09-29" version="1">MSFSFFFFSFFLCFFVSFFLSFFLLILTLTYTFLFLLPLIFIFSPLLCFIFSLSFLLTSSFPFFLPSIFSSDSFMLPLCLYFLLTFSLRFFWTRFLSFFFKFISYCLSFFRFYIAVPRFSYSSIDISFVSKKFSSFYLSDSFSFCLSFFLSFFLSFFLSFFVFVSFFLHAFFLSTIFFSIKYFCFLFMLFFIFFLTFFFSLLYFIFFYYFLFFFSHFFFFYTFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B4J1</accession>
    <name>A0A812B4J1_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serum response factor-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_10392</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000335">
        <property type="protein sequence ID" value="CAE1169037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B4J1"/>
    <dbReference type="OrthoDB" id="3364872at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037393">
        <property type="entry name" value="Bud22/SRFB1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23325">
        <property type="entry name" value="SERUM RESPONSE FACTOR-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23325:SF1">
        <property type="entry name" value="SERUM RESPONSE FACTOR-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1169037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="297" mass="33917" checksum="3377D9EAD95916C6" modified="2021-09-29" version="1">MASKKDSLKETAKPINDKPPDNVENQFGEASSIDKVTLNNTIISMRSTVKKSKIRILAKLIRHIKQLKSKINEKPINTEKNKRKLANLLEEMKIIKALKPDTVSRFVLGNTFTFVELNNKGFQSTEARALARGQESSVEVPEEENKLEKVDQKNDDEPEFTVSGNHSMFLSLSGSDVQSFRDGSGRRGRMNSHSPYSEFRRQKPNSQGHQNPGYRNNFVQGRFSNRGRREKPSTYPLTKTFKESKDTTLKNTPKQKLLDKSNFSDEKLHPSWEASRRRKEQAASISVFQGKKVKFDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B512</accession>
    <name>A0A812B512_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7041 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_10616</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000344">
        <property type="protein sequence ID" value="CAE1169457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B512"/>
    <dbReference type="OrthoDB" id="6251906at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055469">
        <property type="entry name" value="DUF7041"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327">
        <property type="entry name" value="ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327:SF3">
        <property type="entry name" value="RNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23055">
        <property type="entry name" value="DUF7041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7041" evidence="2">
        <location>
            <begin position="3"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1169457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="226" mass="26284" checksum="DEB694E36DEB173A" modified="2021-09-29" version="1">MLRITSQRARFANVMQKLPSDMMDEISDVLSDLRELEPYDHLKEAILKRTGRSEEDMIQEILRNVTRGDKTPSQLLRYMRNQLGKHNVSEKVLRGLWLEHLPKSVAQIIPPMTRTTPLNDLAESADLVFAQFDHSVNAVHAPDMAKHERYEPSKTERALADLQRQIREIQISLRPRTRKSTPSRRRRTPSRERQSDQGVCWFHRTFGDGARNCKPPCTHPSARRNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B5X8</accession>
    <name>A0A812B5X8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_11305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000372">
        <property type="protein sequence ID" value="CAE1170864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B5X8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="266"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="331"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1170864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="390" mass="46387" checksum="9333E49330F5BDD2" modified="2021-09-29" version="1">MEIISRGKHRIPPLRHAPHRFKRSSINTNVPLFISIYLSIYLYLSISICSYLSIPICSYRSISVCSYLSISMCSYLSIYLSIYLSIYLSIYLFQSVHIYLSIYLSIYPNLFISVYLSLFISIYLNVFISICSYLSIYLSIYLSIFSYLSISICSYLSISLSQCVNIYLSVHIYLSIYLSIYLSIYLSISICSYLSQSVHIYLSQSTHIYLNVFISISILFSFFFFFFLFFFCSLVRFFSSSSRFFSFFLFSFFPFVLLFFSFPRLPVLFLFSFFLFFFFHLFSPSSNCFLFFPFVLLFFSFSRFRILLLFLHTLTPFLYNYCYNRFLFRLFYSFSSFLFFSFLFCLASPPATALFAYFHQDSPLFISFHIFLQYTQLYRLFFSIFTPACV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B6N9</accession>
    <name>A0A812B6N9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_11429</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000377">
        <property type="protein sequence ID" value="CAE1171185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B6N9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1171185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="281" mass="34481" checksum="2AE517FAAB77ACB2" modified="2021-09-29" version="1">MIPPLVLFRRFLIIGIYLSIYLSIYLSIYLSIYLSANPLEKFVKIFLIHSVYLSIYLSIYLSIYMVLSFFFLSFFLSFFLFFFLSFFLSFVRSFFFLSFCLCSHLSFSTFILFLYYVSIFVYLFLCPFFLFPNLFFLYFHLSFFLSFFLSFFLSFVFFFFLFCLCLHFFFHFHSFSLLRFHLCLFVFCPFIFSLISFFLYFHLSFFLSFFLSFFSFLSSHFIFILLYIQYFFSIYLSIYLSIYLSIYLSIYLSIFISIYLSIYLSIYLSIYLSIQLQRFLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B7K0</accession>
    <name>A0A812B7K0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_12398</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000415">
        <property type="protein sequence ID" value="CAE1173067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B7K0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="293"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1173067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="377" mass="44731" checksum="8A8380F30769705F" modified="2021-09-29" version="1">MALFISIYLSIYLSIYLSIYLSIYLSIYLSIFRFLLPVIFFIYLSIYLSIYLSISIYRCLFVSIYLSIYLSIYLSIYLCESVHIYLSIYLSIYLSIYCGITNFFVFNEGYVSLVSNAFSLHVIFFIYLSIYLSIYLSIYFTSVLGLVFEVRFSLLPFFIFFYSQILFLHFFFFHFLFHFLCSFVISFSSTHCFHINLISCLFLFLLFTIFYSIYSLSFLHFSLFYLFPRFHFSTRSFFLSFFLSFFLSFYALFLSTRPFFLRTVYFFLATHCSFVCLLLSFFLSFFLSFFLSFFLSFFSISKLFSPVIFLLIIPAYYLSFKILSLSLSLFVALVLFLLIYGYCFSASVPCTPAEAPAIFTEHHLSIHIYLSIYLSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B8M8</accession>
    <name>A0A812B8M8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNAJC28</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_11211</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000370">
        <property type="protein sequence ID" value="CAE1170722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B8M8"/>
    <dbReference type="OrthoDB" id="1922282at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052573">
        <property type="entry name" value="DnaJ_C_subfamily_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018961">
        <property type="entry name" value="DnaJ_homolog_subfam-C_membr-28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39158:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39158">
        <property type="entry name" value="OS08G0560600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09350">
        <property type="entry name" value="DJC28_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DnaJ homologue subfamily C member 28 conserved" evidence="2">
        <location>
            <begin position="97"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1170722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="353" mass="40658" checksum="325620134A9DD422" modified="2021-09-29" version="1">MEKLQQQPQQLPTIDDDKKENKISSSQHRHYLSYEGFGIGTMSQREKQYNQYRMMKATEKVQEYQVKKFTYMQEDAIVLKEKKFTRKLKISSAIDRVVEDLIQEAISKGEFHNLSGSGKSLSFSNHNPMLDITTHNLNKILINNGYTPEWIVMRKDIIENLRNFHSNLAMSFIHTKGSLQKCFSIIFSSNYYNSFSSLPIFILPLHSIPSDPRGIPIILSSNSHTFTPFLFYSSKSATRILSSNSHIPPTSLLQHQMDFPKNPLFQFSYLFPIPLLQFQKGFLITLSSNSHTSTCFIFLPLFQLQHSFLIVLSSNPLLHSLPLLPPPSCLSFSSHCMPHIVTLISFFHQILYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BA91</accession>
    <name>A0A812BA91_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PPP2R3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SPHA_13000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000435">
        <property type="protein sequence ID" value="CAE1174197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BA91"/>
    <dbReference type="OrthoDB" id="10265007at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030865">
        <property type="term" value="P:cortical cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035303">
        <property type="term" value="P:regulation of dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21505">
        <property type="entry name" value="PPP2R3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000091">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039865">
        <property type="entry name" value="PPP2R3C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12085">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2A REGULATORY SUBUNIT B'' SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12085:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A REGULATORY SUBUNIT B'' SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAE1174197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="661" mass="75932" checksum="67826FC5B742DACC" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BBZ0</accession>
    <name>A0A812BBZ0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NOP9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SPHA_14495</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000495">
        <property type="protein sequence ID" value="CAE1177154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BBZ0"/>
    <dbReference type="OrthoDB" id="9987665at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040000">
        <property type="entry name" value="NOP9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13102">
        <property type="entry name" value="NUCLEOLAR PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13102:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22493">
        <property type="entry name" value="PUF_NOP9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="187"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="465"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAE1177154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="509" mass="59478" checksum="09816C8D2F0D2C49" modified="2021-09-29" version="1">MKQEKRSEKAERRNSISDETFNYYKRVHESFKDLTLSGIDQDIFFTNVFRQLENEALVAHKKTDSYKEKLHESKPDETFHKQFFKISKLIINSSHFTNYVSDKAANPVIQLILHITCQLKQHKGEKLCKKLIRLCGFFDVPAVDPETPLTDHTRLPVLMMDVYATYLVQLLLQHCSEELFLAWYESSFKDRLIAYAIHEQSNYVLQHVIERCSSKEMFTFIFDEITPYLEDMLSMKHMGVIKTLIRKCLTLGTKQKKIVKKLLDAFHCTEEDKKILIVPLLMVMKTYEVYMENITIDDEVEKPEKFAKIIINIHGSMIVQTLFNFGNPKLFVDSFLSLTPKQMVSVMCSYFGNFMIKEYFKSSTIGEKSKDAVLQKISGSYSDIACDRIGSHTWQDIWNYLNINQKTNIAEELCKQIEKVRKNKYGVYVYANLALGTYRHNCQQWQTSQAALTNKRKMFKDILDPNEVRKKSKKSSKSKENKQDCLNSNDQPDDAIDFDLFKPKNKVKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BCL3</accession>
    <name>A0A812BCL3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_14328</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000490">
        <property type="protein sequence ID" value="CAE1176843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BCL3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1176843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="243" mass="29379" checksum="EC908AB1ACE4E7C6" modified="2021-09-29" version="1">MFHFLLSFYAFICFFLLFFRLPIFLILLFLPFVYSFFYFRFLPFFFCVSFLSFIFFFQLIYFLLLLLKFSVSCSSFLSYLVCFSYIFSSSTFFSSFSFFYYSFFEIIYFPIVSFHPFLPSFVSTVSSSLSASSSPFFFVFLFFHLCLYLLSFLLSLASCQFSILFGSSFDFTDQAIFYENKPRLNKFFFFFKNTHLFLNIFFFLSFLSKFYQYQKIRHRGVRNAIPIRNEISIWICPSGEYYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BDZ4</accession>
    <name>A0A812BDZ4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_15660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000547">
        <property type="protein sequence ID" value="CAE1225332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BDZ4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1225332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="255" mass="29822" checksum="04E8D74BCBF4A94E" modified="2021-09-29" version="1">MNSSQVFHIYFSSSIQSHQSTLYFPCLIFASYLLILLALHLSFHSLFTDSHFIFLFPYSPFISFISLFTLYFFTFFSFALFPYSPFISFFLLTLLSFPLFLYSPFIRSLYLLSFHFLSSLTLLSFPLFFYSPFISFLPLLSFHLLSSLTLLSFPFFLCSPFICSLPLLFFHFLSSLTLLSFALFPYSPFISFYFCSFFTLFSLPHLLSTPFISLLTIHFLFSLTLFSFLFFLALLSFPLLTLHSEPTINFPSLFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BF65</accession>
    <name>A0A812BF65_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_15574</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000543">
        <property type="protein sequence ID" value="CAE1224953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BF65"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1224953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="224" mass="26161" checksum="CA7C0D99E9A16C8F" modified="2021-09-29" version="1">MGLPFDFPVLNLYTPIGSEWQFFEYAGDAKLISIYLSIYLSIYLFIYLSIYLNLSPTTKSSVTGSKLINENSRKMFWLITHSLTHSIYLSIYFFYLSISDLSINLICSYLSIYLSIYLSIYLSMSVHVVNKYLSIYLSIYLSIYHCCFHVKNINEKYGPANFLSMSIHNYVPIYHSLYLSQSVHIYLSIYLSIYLSIYLSIAVCSYLSIYLSIYLRRRLYQGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BFH5</accession>
    <name>A0A812BFH5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_16422</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000577">
        <property type="protein sequence ID" value="CAE1227522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BFH5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1227522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="302" mass="34826" checksum="E0ACF76B1E189356" modified="2021-09-29" version="1">MNSTSAHFQSLDVGQCDRVHWSLITAAPITSLFFLSFLLTESISLIQFISFSHTLSTFLCILTSIFFPFHLSSQFSFLFCITISISPTAFLSPSLFFLFLLIPLSDFHPFSQFHSLFPLSISVFYIFLFFSLFRRFSQFSIFLSLFLFPSFCFSFSLFLIPFLYFSFPSFLSLFVFPPFSLLNSLVSYSLFSFPDFTQAPLFLNSLSSKQSRYLYAPLSIRPLLTLFDSLMYLLNFTRKVYLFSFFSYPSLIISQYFSLASSCIFPEISTLSISPYFSLAVTLVSVYFFLSVVDPCLTRLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BGU1</accession>
    <name>A0A812BGU1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Leucine-rich repeat and guanylate kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SPHA_18288</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000659">
        <property type="protein sequence ID" value="CAE1231936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BGU1"/>
    <dbReference type="OrthoDB" id="6334211at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004385">
        <property type="term" value="F:GMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031701">
        <property type="entry name" value="SIX1_SD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23117">
        <property type="entry name" value="GUANYLATE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23117:SF18">
        <property type="entry name" value="LEUCINE-RICH REPEAT AND GUANYLATE KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16878">
        <property type="entry name" value="SIX1_SD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Guanylate kinase-like" evidence="5">
        <location>
            <begin position="369"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="627"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="636"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="664"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAE1231936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="921" mass="104556" checksum="D3B8663988E2989B" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BGZ8</accession>
    <name>A0A812BGZ8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_16456</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000579">
        <property type="protein sequence ID" value="CAE1227610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="414"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="444"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="475"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="506"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="545"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="571"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="593"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="644"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="668"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="706"/>
            <end position="733"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="745"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="847"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="908"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="944"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="990"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1011"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1038"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1067"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1098"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1126"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1157"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1190"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1217"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1242"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1266"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1300"/>
            <end position="1324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1330"/>
            <end position="1354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1227610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1357" mass="165048" checksum="8A289072E38C2B12" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BI10</accession>
    <name>A0A812BI10_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="14">SEH1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SPHA_20590</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Lysosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat SEC13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000756">
        <property type="protein sequence ID" value="CAE1237127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BI10"/>
    <dbReference type="OrthoDB" id="364224at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035859">
        <property type="term" value="C:Seh1-associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000063">
        <property type="entry name" value="SEH1 like nucleoporin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037363">
        <property type="entry name" value="Sec13/Seh1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN SEC13 / SEH1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024:SF3">
        <property type="entry name" value="NUCLEOPORIN SEH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="10" id="KW-0458">Lysosome</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="5 13" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="8"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="270"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAE1237127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="367" mass="40839" checksum="88C7C9E51FF37E52" modified="2021-09-29" version="1">MFAPKSIQTDHEDLIHDVAYDFYGKRLATCSSDQTVKIWDKSEDGQWRQSACWKAHTGSVWRVTWAHPDFGQVIATCSFDRAAGIWEELPCESRDETSKTKWVKRPNLVDSRSSVTDVKFAPKHLGLQLATCTSDGMVRIYQAPDVMNLSHWSLDYEIHCKLSCSSLSWNPTRSCPPMIAVGSDDANLSAGGKVFVYQYNDQLRSWSKLQTLALVTDPVHDLAFSPNFGRSYHRLAIASKDLKIINMVPIKQDNNLETGTEYEITLVGQFDDHEHQVWRLSWNVMGTVLASSGDDGKVRLWKANYLGNWKCISVLVGDIPSSIPESSSQSRLDLSPVGQASTVASGSASNKRYPRVVPGGNFGAAMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BJC5</accession>
    <name>A0A812BJC5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_18416</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000667">
        <property type="protein sequence ID" value="CAE1232219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BJC5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1232219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="258" mass="30709" checksum="C64225D57A5C80FB" modified="2021-09-29" version="1">MAMKQAMTTILEKSVHIYLSFYVSLFISIYLSIYLSIYLSISISIYISIYLSLLIRIYIDREIYIYIYIFIFIYFIICSYLSIYLSIYLSIYLSIYLSLYIYLSKSVHIYLSIYLPIYLSIYLSIYIYIYIYIYIYIFIPLCSYLSIYLSIYLSIYLSIYQPKSVHNYLNLFISIYLSIYLSIYLSIYLSIYVFISISICSYLSIYLSIYLSIYLSIYLFQSLNFSLSLSPPPPISLFIYSDPFPVFITGIDNQLHTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BK45</accession>
    <name>A0A812BK45_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_19142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000693">
        <property type="protein sequence ID" value="CAE1233873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BK45"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1233873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="248" mass="29397" checksum="2E8DF142D8FA83B0" modified="2021-09-29" version="1">MNEVYLCQLQIFFCAFFITQTNFIFTFEKQLLYLLCHPFISLYLSPLLPSLSHQHFFFFFFFFIIIITFFFFITIIFFFIIIIIFLSIFLSFSFTSCHPFSFTLSLSTFVFSLSSTISSFSSSSSSSCSCSSSYYFSFFSFLSYHFNLFCIHFSSSFFLSYFSFTFSHIFHSRSFSSFVSFPLSTSIFIKYFLLVSFSFLCLSIQHQLAFLSIILNLRLLFFFRLFLPYFAKNFSSFHGDLKNTKKCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BNR0</accession>
    <name>A0A812BNR0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_23935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000888">
        <property type="protein sequence ID" value="CAE1243678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BNR0"/>
    <dbReference type="OrthoDB" id="8957827at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21698">
        <property type="entry name" value="PROTEIN (PUTATIVE)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21698:SF4">
        <property type="entry name" value="PROTEIN (PUTATIVE)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="341"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="401"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="431"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1243678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="500" mass="57736" checksum="F445B470B3045592" modified="2021-09-29" version="1">MQVYLSTYLPPFNSLSLHPFISLSLLRSYLSAYPSISVHIYLPIHLSPFISICLSIYLRSYLSAYPSISVHIYLPIHLSPFISICLSIYLRSYLSAYPSISVHIYLPIHLSPFISICLSIYLRSYLSAYPSISVHIYLPIHQSPFISICLSIYLRSYLSAYPSISVHIYLPIYLSPFISMYLPISVHIYLTISISPKKYSGYLSSFISTYFCSFISISLPSCLHIDRSPFIHILSPFHIYLFYLNLAALDLQMPLQWHSPLRRNHHLFRARLLLQQSTCCRVASVGDLELLATFVSLSFHHPFMQAHQLCYDGECFPTISSYLSIYLSQFLSIYLSKSVPIYLSIYLSQFLSIYLSQFLSIYLSQFLSIYLSQFLSIYLSQFLSIYLSQFLSIYLSQFLSIYLSQFLSIYLSQFLSIYLSQFLSIYLSKSVPIYLSIYLSQFLSIYLSIYLSKSVPIYLSIYLSQFLSIYLSKYLPKSVLSIYLSIYLSASPAVNKHCLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BP32</accession>
    <name>A0A812BP32_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_19126</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000692">
        <property type="protein sequence ID" value="CAE1233847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BP32"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1233847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="197" mass="23210" checksum="831B05633DBD334A" modified="2021-09-29" version="1">MRNIHVHPVLNVASIVRIYLSIYLSIYLKSLNILSFYIQKYLVASGNFSRYSSPIIRQDFEFRSRKMNTNLISIYLSIYLSIYLSIYLSIYLSISFCSLSIYLSIYLSHFVHYLSIYLSIYVSAIFQFSSVWSETRSRFYNIYLSIYLSIYLSIYLSIFYEIILWLEKSFPLPTAEILYGMLYPGITISLSVAFHIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BUE2</accession>
    <name>A0A812BUE2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LBP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SPHA_23789</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Farmed</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000881">
        <property type="protein sequence ID" value="CAE1243401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BUE2"/>
    <dbReference type="OrthoDB" id="10255543at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.20.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017943">
        <property type="entry name" value="Bactericidal_perm-incr_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032942">
        <property type="entry name" value="BPI/LBP/Plunc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001124">
        <property type="entry name" value="Lipid-bd_serum_glycop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017942">
        <property type="entry name" value="Lipid-bd_serum_glycop_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10504">
        <property type="entry name" value="BACTERICIDAL PERMEABILITY-INCREASING BPI PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10504:SF131">
        <property type="entry name" value="BPI2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01273">
        <property type="entry name" value="LBP_BPI_CETP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02886">
        <property type="entry name" value="LBP_BPI_CETP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00328">
        <property type="entry name" value="BPI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00329">
        <property type="entry name" value="BPI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55394">
        <property type="entry name" value="Bactericidal permeability-increasing protein, BPI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="119"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="204"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Lipid-binding serum glycoprotein N-terminal" evidence="4">
        <location>
            <begin position="316"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="Lipid-binding serum glycoprotein C-terminal" evidence="5">
        <location>
            <begin position="556"/>
            <end position="762"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAE1243401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="826" mass="93845" checksum="67F1B199E2039E01" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BUL8</accession>
    <name>A0A812BUL8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_22032</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000813">
        <property type="protein sequence ID" value="CAE1239886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BUL8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="311"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="374"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="406"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="447"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="471"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1239886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="497" mass="58694" checksum="437FC518E9241021" modified="2021-09-29" version="1">MFFSLTPSLSLDESYPVRLLFIDSHFLSLTLTLFLSLSHSFSLSLMTFHRFLYSSTPAPYFFLLISLTFHFESLFLSFFFFSFFPFFSFPHANQLFYPSLSLSLVSSILSFFLSLYVSIYLSIYLCSYISMFILIYLLIFVFTDLCSYLSIYLSIYLSIYLSLYLSIYPSLFISIYLSIYLSIYLSLLILIYLSIYLSMFIHIYVHTYLSIYLSLYLSIYLSIYLSIYLSIYLCFTYLLLIFICLLYLSIFLSIYLSIYLSIFIHIYVHTYLSIYLSIYLYVFVLIYLSIYLSLYISMFILIYLSIYLSIYLSICLCTYLSIYLCLYISMFILIYLSIYLSIYLSIYLSISPVSIYLSISLFPHIYLSIYLSIYLSIYLIACFTYLSIYLSIYLSIYLSISLLPHIYLSIYLSIYLSIYLSIYLSVVYDTPNLHKWSTDHINMASTLSIYLSNSLFPHIYLSIYLSIYLSIYLLVCSHISIYLSIYLSIYLSIYLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BVV6</accession>
    <name>A0A812BVV6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_24539</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000916">
        <property type="protein sequence ID" value="CAE1244967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BVV6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="343"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="399"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="438"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1244967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="541" mass="63651" checksum="18383877C6E00046" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BX46</accession>
    <name>A0A812BX46_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_23338</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
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            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
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            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000864">
        <property type="protein sequence ID" value="CAE1242530.1"/>
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        <source>
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        <source>
            <dbReference type="EMBL" id="CAE1242530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="490" mass="58822" checksum="7C7FE0050F35CC5D" modified="2021-09-29" version="1">MLSFFFLFYPFFLSFFLSIIFFLSFSLSFFLSFFLFFTLSFFLIYTPSFLLYFFLFFFLKVTLSFLLSFFLSFFLIFSFFLIFTLSDIHSFFLSFFLSFFLSFLFSRFLSFLPSFFLFSFLIFFYLHSFFLIHTLSDFHSFLFSLFLSFFLSFFHSLLFSFILFVFCSIFSFCFSFFLSFFLSFFLSFFLSFFLIFIFLLFNRFISYSSKPSNFFLLTPLFPPLSLSRSLSIYPMRVSNNCSIYHLSIIYHLSIHYLSIYLSIYFSNCLFPITVLSHPYLSIYLSIYLYLSIYLSIYLSIYLSLLIYLSIYLSLSIYLSLFLYLSIYLYLSIYLSIYLSIYIYIYLSISFFLLSISLIYYLSLYLSICHSVSLSYVGDYIVWAHLSIYLSIYLSIYLSIYLSIYIYISIYIYIYLSIYIYIYISLNDFSVSASLSFAILFLSLQLSLSPVHIIIYLSIYLSIYIYIYIYLSILSIYPYCLSIYLSIYLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BXB7</accession>
    <name>A0A812BXB7_ACAPH</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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                <person name="Bekaert M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
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    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
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        </submittedName>
    </protein>
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    <organism evidence="2 3">
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
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    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001136">
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        </source>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="225" mass="26530" checksum="2B068199FFB651EF" modified="2021-09-29" version="1">MIPSAHPYNLFLSLFLSYCLFHMIPSAHPYNLFLSLFLSYCLFHMIPSAHPYNLFVSLFLSYCLFHMIPSAHPYNLFVSLFLSYCLCFLFIHMIPSAHPYNLFRFFVSFSVHMKPSAHPYNLFVSLFLSYCLCFLFIHMIPSAHPYNLFLSLFLFLLFFLLSILSLFSFSVHMIPSVIHIICFFLCFFHCLLFSFSVHMIPSAHPYNLFVSLFLFLLSLFPFQFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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    <name>A0A812BY13_ACAPH</name>
    <protein>
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        </submittedName>
    </protein>
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    <organism evidence="2 3">
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
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        <source>
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        </source>
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        <source>
            <dbReference type="EMBL" id="CAE1248482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="168" mass="20454" checksum="73E07C98B6972AA4" modified="2021-09-29" version="1">MEKTLKSEIIYLSIYLSIYLSIYLILFILLYFTKFLFSHRLSYTPSFFLNSRPMNAVIPRLQMESIYLSIYLSIYLSIYLSMCINRFLVKHFVEVNRFLYRRIWMHINAQKFTLSIYLSIYLSIYLSIYIYINYKTRIMTFIDVFLSIYLSIYLSIYLSIYLSIYLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BZS1</accession>
    <name>A0A812BZS1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_26684</name>
    </gene>
    <organism evidence="2 3">
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        <name type="common">Pharaoh cuttlefish</name>
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        <lineage>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
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    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="316"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="399"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="434"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="462"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="495"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="522"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1249584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="549" mass="62418" checksum="4A5EB18EA004B858" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C5Q8</accession>
    <name>A0A812C5Q8_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">tRNA wybutosine-synthesizing protein 4</fullName>
            <ecNumber evidence="4">2.1.1.290</ecNumber>
            <ecNumber evidence="3">2.3.1.231</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Leucine carboxyl methyltransferase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">tRNA(Phe) (7-(3-amino-3-(methoxycarbonyl)propyl)wyosine(37)-N)-methoxycarbonyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-O)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SPHA_31718</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Farmed</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. May methylate the carboxyl group of leucine residues to form alpha-leucine ester residues.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>7-[(3S)-(3-amino-3-methoxycarbonyl)propyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine + CO2 = wybutosine(37) in tRNA(Phe) + S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:37119"/>
            <dbReference type="Rhea" id="RHEA-COMP:11844"/>
            <dbReference type="Rhea" id="RHEA-COMP:11847"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73544"/>
            <dbReference type="ChEBI" id="CHEBI:74275"/>
            <dbReference type="EC" id="2.3.1.231"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine = 7-[(3S)-(3-amino-3-methoxycarbonyl)propyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:36903"/>
            <dbReference type="Rhea" id="RHEA-COMP:10379"/>
            <dbReference type="Rhea" id="RHEA-COMP:11844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73543"/>
            <dbReference type="ChEBI" id="CHEBI:74275"/>
            <dbReference type="EC" id="2.1.1.290"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. LCMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.290" evidence="4"/>
    <dbReference type="EC" id="2.3.1.231" evidence="3"/>
    <dbReference type="EMBL" id="CAHIKZ030001311">
        <property type="protein sequence ID" value="CAE1259505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C5Q8"/>
    <dbReference type="OrthoDB" id="263283at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031591">
        <property type="term" value="P:wybutosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.650:FF:000043">
        <property type="entry name" value="tRNA wybutosine-synthesizing protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461:SF104">
        <property type="entry name" value="TRNA WYBUTOSINE-SYNTHESIZING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="JmjC" evidence="15">
        <location>
            <begin position="136"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAE1259505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="341" mass="39617" checksum="2BBB4256677977ED" modified="2021-09-29" version="1">MAAAESLKCFRCNLPKKTKQVPILKDVTAELFQKELYPKRRPVVLRGFDIGDCVEKWTTEYLIANAGNKQVNVHVSSTHQMDFINKNFLYRTLPFGELVKRASKEINEDYFISPDEKYYLRSLGDDPRKSVADVRQQFPHLMKDLNIPPLFPAENFFSSVFRIASKSCQLWTHYDVMDNILMQIRGHKKVVLFSPQDAHFLYLKGDKSEVLDIDDVNTQNFPLFTNATRYECLLEPGDIIFIPALWFHNVISEEFGVAVNVFWKHLDSSLYCQKDPYGNKDPVAVISAFQIVDRAVKALECLPKEYQDFYGRMLVSRIEKKCYLKDLEENEFTNKDDCCES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C6C6</accession>
    <name>A0A812C6C6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_30925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001250">
        <property type="protein sequence ID" value="CAE1257767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C6C6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1257767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="887" mass="102117" checksum="067F37D7A95025F7" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C7J8</accession>
    <name>A0A812C7J8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="20">GRIN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">SPHA_34086</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Postsynaptic cell membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001440">
        <property type="protein sequence ID" value="CAE1264202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C7J8"/>
    <dbReference type="OrthoDB" id="5984008at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000060">
        <property type="entry name" value="Glutamate receptor ionotropic, kainate 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001508">
        <property type="entry name" value="Iono_Glu_rcpt_met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015683">
        <property type="entry name" value="Ionotropic_Glu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18966">
        <property type="entry name" value="IONOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00177">
        <property type="entry name" value="NMDARECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="17" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0770">Synapse</keyword>
    <keyword evidence="3 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="219"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="19">
        <location>
            <begin position="1"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="site" description="Crucial to convey clamshell closure to channel opening" evidence="16">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with the cone snail toxin Con-ikot-ikot" evidence="16">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with the cone snail toxin Con-ikot-ikot" evidence="16">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="144"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CAE1264202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="310" mass="34588" checksum="988A0FA18C026CC3" modified="2021-09-29" version="1">MLSIYLSIYLSIYLSISCEFSPRAISTRLVSGTWWFFTLIMISSYTANLAAFLTVERMISPIERADDLAKQSDIKYGTLYGGSTMTFFKTSKIPTYQRMWHVMDSTEPSVFVNSSQEGIDRVLKGNYAYLGESAIIDYNVQRNCDLMQVGGRLDSKGYGIATPRESPYRDLISDAILKLQEEQVITLLYNKWWREGYGAVKCENEDANKDASELGVSTVGGVFVVLGGGLATGLIAAMMEFVWKAKKNAEEDKRSICAEMLREFRFAMKCFGSSKKTVKKGPRKKSITDNGIHFMPLAGFSAATGKEAYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CB47</accession>
    <name>A0A812CB47_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_31598</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001302">
        <property type="protein sequence ID" value="CAE1259248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CB47"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1259248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="277" mass="32040" checksum="9FDB9E3FE155273B" modified="2021-09-29" version="1">MFVPFFALRVISGYPTPLANPSTFFTATPFSIVLSRSSFVKQTRQFFPSVSRYSFTLTCPFSLSLVKFPSNLRHSIYLSIYLSIYLSICLFLYICLNKFLSIYLSIYLSIYLSICFFIAVLICSYLSIYLSIYLFFIAVLICSYLSIYLSICFFIAVLICSYLSIYLSIYLSISVLICSYLSIYLSIYLFLYSCLNMFISIYLSIYLSIYLSIYLSIYVILCSRNTIVTYLLFSKFISNIHIFNILILGFSIYLSIYLSIYLSIYLSTHIMGNSTSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CBL0</accession>
    <name>A0A812CBL0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_32919</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001370">
        <property type="protein sequence ID" value="CAE1261829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CBL0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022324">
        <property type="entry name" value="Bacilysin_exporter_BacE_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01988">
        <property type="entry name" value="EXPORTERBACE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="336"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="388"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="418"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="447"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="477"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="506"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="535"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="561"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="589"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1261829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="613" mass="79213" checksum="7DAC2B3E899C2A01" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CD36</accession>
    <name>A0A812CD36_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_31929</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001324">
        <property type="protein sequence ID" value="CAE1259970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CD36"/>
    <dbReference type="OrthoDB" id="425681at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1259970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="155" mass="18177" checksum="746D0662771135BC" modified="2021-09-29" version="1">MIFVALLFERCREQKREIDFALADLNKAFDMVNPEAPCLLTGNLSVCRPFRGNFTRICLLRYPSRDPYQNCLHTGVKESCVLAPVLFNIYLVSVTILSRLHMEPSDGIRIRYRFERSVFNARRFNAKNLPFLPMKCIMPTMLPYFLMRHPHYNSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CFF3</accession>
    <name>A0A812CFF3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_33861</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001424">
        <property type="protein sequence ID" value="CAE1263674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CFF3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1263674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="210" mass="24533" checksum="0778E3E475A03E3D" modified="2021-09-29" version="1">MRSFNTTPVVCSCYNSLSIVFLWSRQTAVISCYLTLPVGPSIVFPVFQGLLKDITLPVGRKRRQSHVFVNVKTMFVLLSSIYLCRQTFFFITPTNGHYKIRKKRRPLSITQFCRSPFDDLSIYLSIYLSIYLSIYLSIYLILLKSIYLNLLVSIYLSISVCRYLFLNLSVYLSQSLNIYLSIYLSIYLSIYLSISLSLSLYIYIYIYIYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CFU3</accession>
    <name>A0A812CFU3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MRC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SPHA_33396</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001398">
        <property type="protein sequence ID" value="CAE1262805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CFU3"/>
    <dbReference type="OrthoDB" id="8935730at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032782960" evidence="2">
        <location>
            <begin position="17"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="23"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAE1262805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="202" mass="23381" checksum="49FB8175D9A10554" modified="2021-09-29" version="1">MRCVIFLFLFIKTVSSSSNWIRFESKCFQKNIKHVNRSTAIEICQQNGAVLTSVSNQKEMDFLGSILKPSEQYWVWLTFKDGRYQWEDGQSCCPRSWWSPTEPSHNDTCARLYRIKGSFQLWDMQCGSLYGFICSKAAKVWTLVSKNDYYFDELCGVEIMPNCKGHQCEDVCQSHHDCTQFAKMSNLYIISLSLSLSHGDQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CHB0</accession>
    <name>A0A812CHB0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_34740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001480">
        <property type="protein sequence ID" value="CAE1265523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CHB0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1265523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="279" mass="32531" checksum="E57DB48D5C8074DF" modified="2021-09-29" version="1">MVGIRSSYFCLDKSIYLSIYLSIYHLSSLISLYSYLPIYLSHIYLSIYLSIYLSIYIHLSIFVNLSLYSYLSLYVCIYLSISSVRIYQSIYLSIYLSIYLSIRICQSICPSLSLYSYLFIYISQPVSFFLSIYLSIYLSIYLSISLFVSVNLSVPLSVYTVIYLSIYLSHCFFFFSLSIYLSIYLSIYFYSLSISIYLSIYLSIYLSSCLSISIYLSLSLCSCILISLFHLSIYLSIYLSIYLSIYLSSFLLIFIYLSVYLSIYLSIYLSIYLSISIYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CHW5</accession>
    <name>A0A812CHW5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_35139</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001510">
        <property type="protein sequence ID" value="CAE1266395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CHW5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1266395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="277" mass="30325" checksum="0B542BA812F173EE" modified="2021-09-29" version="1">MFAFLSEAGHRRQIDSMLHSYQEAGHGAKSILCAFLSKKLAIGAKSILCCILIKKLAIGAKSILCCILIKKLAANQIDSMLHSYQEAGLGANRFYVAFLSKLAIGPNRFYDAFLSSKSSLYYQGMKAGHRRQIDSMLHSYQEGHWRQIDSMLHSYQEAGPGAKSILCCILIKKLAIGAKSILCCILIKKLAIGAKSILCCILIKKLAIGAKSILCCILIKKLAIGAKSILCCILIKKLAKAPNRFYVAFLSEAGHRRQIDSMLHSLSSWAIGTKSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CHX2</accession>
    <name>A0A812CHX2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WWOX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_37814</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001699">
        <property type="protein sequence ID" value="CAE1272785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CHX2"/>
    <dbReference type="OrthoDB" id="9989144at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000353">
        <property type="entry name" value="WW domain-containing oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="127"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1272785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="424" mass="48451" checksum="5FE2E97C40705850" modified="2021-09-29" version="1">MISFFFLSIFIGLSFFFFSIVHLFASLAILSFFIPFFLSTAFLIIFFFFAFHFLFTSFFLSSWPFSYFSIVILQLFLSPSLSFNCAFLFSYFHFNFTIPFNLHFYFSPFFQFLSFSQTQWKLILTDIHISFFFPLLLSHRLYLLFISLFAGFETARTLAFHGATVILACRNLESAAAASEKILAERSTAEVEIMALDLASLKSVRYFADTYKCRKWPLHILILNAGVFGLPYTATEDNVEITFQVNHLSHFYLSLLLKDVMVSSNPCRIVVVSSESHRFSDLSSENISEEKLSLPSSQYKDMSAYNTSKLCNILFATELNQRLLPLGVTVNALHPGNMMSSNLARNWWVYRLLFAVVRPFTKTMQQGAATSLYCAAVPELQGIGGMYFNNCCRCEPSSAAQNGKLATALWEISTKMLSDRSFVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CID4</accession>
    <name>A0A812CID4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_36575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001602">
        <property type="protein sequence ID" value="CAE1269427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CID4"/>
    <dbReference type="OrthoDB" id="6425635at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1269427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="170" mass="18541" checksum="955B2073A88AEEEF" modified="2021-09-29" version="1">MRPKRRKLLGRRTAAASAARAARASETPEQTSLRLSRMASSSAARLSTESAAARTEKLASAASTMSACRARLSAEERSLQNSQDAVREARLRASQSPAQKTIRRLRDATVKACSRGLESPEQTTSRRLRNTRDTAASRASEQPQETAHRRFRNGLSTASARACTNHCSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CKX1</accession>
    <name>A0A812CKX1_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytosolic Fe-S cluster assembly factor NUBP2 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SPHA_35599</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Farmed</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Negatively regulates cilium formation and structure.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="12">Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of NUBP1 and two labile, bridging clusters between subunits of the NUBP1-NUBP2 heterotetramer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Heterotetramer of 2 NUBP1 and 2 NUBP2 chains. Interacts with KIFC1. Interacts with NUBP1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Cilium axoneme</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001536">
        <property type="protein sequence ID" value="CAE1267414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CKX1"/>
    <dbReference type="OrthoDB" id="1741334at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02037">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000796">
        <property type="entry name" value="Cytosolic Fe-S cluster assembly factor NUBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03039">
        <property type="entry name" value="NUBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028600">
        <property type="entry name" value="NUBP2/Cfd1_eukaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264:SF19">
        <property type="entry name" value="CYTOSOLIC FE-S CLUSTER ASSEMBLY FACTOR NUBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264">
        <property type="entry name" value="NUCLEOTIDE-BINDING PROTEIN NBP35 YEAST -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 12" id="KW-0408">Iron</keyword>
    <keyword evidence="9 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="23"/>
            <end position="30"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00053368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00065349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAE1267414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="270" mass="29295" checksum="43D8E50608B4B605" modified="2021-09-29" version="1">MAAPTDSTDNLSSVKHVILILSGKGGVGKSTLATQLTLGLLKAGKKVGILDVDLCGPSIPKMLNLENRDVHMYPTGWLPVYIDDEKRLGVMSIAFLLDNKDEAVVWRGPRKTAMIRQFITDVCWQDVEYLIIDTPPGTSDEHIAVVESLKSYNPDGAILVTTPQDISVGDVRREATFCQKTGIPILGIIENMSGFVCPNCKECSNVFSKGGGEALARELGIPFLGCVPLDQHLSMSLEEGKNFITEHSDSPAVMALTSVVDRLIQIDKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CRY4</accession>
    <name>A0A812CRY4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_42295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002062">
        <property type="protein sequence ID" value="CAE1280386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CRY4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23304:SF189">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23304">
        <property type="entry name" value="SPOT2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="308"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="346"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="375"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="412"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="439"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="482"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="521"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="563"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="605"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="704"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="774"/>
            <end position="806"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1280386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="812" mass="92912" checksum="F1CAB8290BFF5814" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CSY3</accession>
    <name>A0A812CSY3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_40440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001909">
        <property type="protein sequence ID" value="CAE1277133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CSY3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1277133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="171" mass="20028" checksum="4AE8C22866E11E88" modified="2021-09-29" version="1">MQRNSKQCQNNTSQIQDDKRSHYNFPICSRSLSLFKSLNLMPKRTTPEGRLKSFLFSVHIQRNSQCSAIDLSIYKEDGRIPLYLLYICLSIAYYLSIYLSIYLSIYLSICCGFRDEIRSQMNDKHYVIYLSIYCVISIYLSIYLLGGPLNTIYLSIYLSIYLSIYLSIFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CU70</accession>
    <name>A0A812CU70_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_41769</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002015">
        <property type="protein sequence ID" value="CAE1279398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CU70"/>
    <dbReference type="OrthoDB" id="4779276at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033234">
        <property type="term" value="P:negative regulation of protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043375">
        <property type="entry name" value="FSCB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36135">
        <property type="entry name" value="FIBROUS SHEATH CABYR-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36135:SF1">
        <property type="entry name" value="FIBROUS SHEATH CABYR-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="435"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1279398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="463" mass="49656" checksum="FCF4045B85A7A061" modified="2021-09-29" version="1">MSSCLSGEVLSVIDAKVTARASPGDSSTPGKPRRPCKIHGKIPVNKIQGDKIQGDKISADKIPADEIPVNKIQGDKIPVDEISADKIPVDVIPADKIPADEIPADKIPVNKIPADKIPANKIPVNKIPVDEIPADKIPEQNPSGRNPSGQNPSGRNPSGQNPSEQNPSEQNPSGRNPSGQNPSEQNPSGRNPSEQNPSGQNPSEQNPSGQYPSDKIPADEIPADKIPQQNPSGQNPSGRNPSGQNPSEQNPSEQNPSGRNPSGQNPSEQNPSGRNPSEQNPSGQDPSKQNPSGRNPSGQYPSEQNPSGRNPRTKNPSEQNPSERNPFGQNPSEQNHNEQNPSEQNPSGQNPMDEIPADKIPVNKIPANKIPVDVIPADKIPVNKIPADEIPVNKIPVDKIPASKIPADEIPADNIPANKIPADEIPADKIPIDEVSIYLSIYLSIYLSIYLSIYLYIYMSDCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CXV9</accession>
    <name>A0A812CXV9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_42937</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002118">
        <property type="protein sequence ID" value="CAE1281538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CXV9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1281538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="186" mass="21874" checksum="7CCE7D01DEA87092" modified="2021-09-29" version="1">MYIHIPLFLPKSFNHFLKTVGLLSFCLRNIFILSLSLSLSLSALCLFFTFFFFLIFSFNDSLFLFVFFYFLSLLLSLSFTLVLYLSLSFCHSLSYSLLFLSQNYTLSLFCCFYHSVCFPQFFSIHWNRPPISLSPSLHPCSHDFPLSHFYIISMIIFIQHFILSLWLYLTLLLSPIIIFVFLCLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CZI8</accession>
    <name>A0A812CZI8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_46651</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002479">
        <property type="protein sequence ID" value="CAE1287509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CZI8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="317"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="398"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="432"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="465"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="498"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="527"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1287509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="548" mass="59039" checksum="E0C31B47EEF35CFC" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D0D2</accession>
    <name>A0A812D0D2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_45124</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002323">
        <property type="protein sequence ID" value="CAE1285015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D0D2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1285015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="211" mass="23607" checksum="A4959A6EE1CBF5FD" modified="2021-09-29" version="1">MPRLTQFFIAADVVVVAAVVVVVVVVLLLLLLLLLLLLSQQIKSKFQSPYLSIYLSVCYIHLFCIYFICNLIHINLSITGIFNFSLSLSLFILLPQCFFSNSLSLISPQVFFPFLCCFFLLSKIKFVDAVRPARATKTSGHLTTISLIGKTKRASSSLRQMRRKCGDPITFSLAIIFSYLLFVKSSSLSSSTLLIRGTGCKKLEDCWCHAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D0U8</accession>
    <name>A0A812D0U8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_45475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002346">
        <property type="protein sequence ID" value="CAE1285514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D0U8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="344"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="382"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="420"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="453"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1285514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="473" mass="55536" checksum="3AD4F0447925093A" modified="2021-09-29" version="1">MQKLSILTFLIYLSIYLSQSVHFISIYLSIYLSIYLSIYLVRWVNSFLRVIFRKLQTWLGFGLDRPILVPTNKRYGTGTSLKRFLFKSKKCKAFFLSFFLSFFLSKYIYLSIYLSIYLSIYLSFSSIYLSISIYLSIYHYIYPSPSVHLSIYLSIYLSIYLSIYLSFSVCSLSIYLSIYLFSYFSFICEPLIVIKKSIYLSIYLSIYLSIYLNLFVSMCLSILVASYLSIYLSIYLSIYLSIYISRFISIYLSIYLSISISSYLCVYLSRFISIYLSIYLSIYLSYRFTYLSIYLSIYLSIYLSILVASYLSIYLSIYLSIYLSIYLSISISLYLCLASYLRRFISIYLSIYLSIYLASYLIASHPSIYLSIYLSIYLSRFISIYLSIYLSILSLPHLSIYLSIYLSIYLSQSFHISLSIYLSIYLSIYLSISVASYLSIDFLSIYICLSQSLHIYLVIYLSLFIIYLSILVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D5B7</accession>
    <name>A0A812D5B7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_45567</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002353">
        <property type="protein sequence ID" value="CAE1285703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D5B7"/>
    <dbReference type="OrthoDB" id="272985at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009306">
        <property type="entry name" value="DUF963"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06131">
        <property type="entry name" value="DUF963"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1285703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="167" mass="17765" checksum="6E2A64CB961EE86C" modified="2021-09-29" version="1">MFADRKMLLLHDSGAVSFQNLRTVGEILPTFKTSCLRYGLLSNHDTLEHALLETAACRMPLHLRVMFATLCTSHSCTFQHSCSLQLIPAPSSTPAAFSSFLHLPALSCSLQLTPAASSTPEASGTPAASSTPTASSSLLQFTAHPCGALLTSRVLFQHPLTTLSSAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D5V7</accession>
    <name>A0A812D5V7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_47585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002588">
        <property type="protein sequence ID" value="CAE1289297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D5V7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="279"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="312"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="341"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="370"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1289297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="395" mass="47048" checksum="C31B554DBEA9208B" modified="2021-09-29" version="1">MKDAFQKLSNILCFSIYLSIYLSIYLSIYLSIYLNLYIYLSFYLSINQSIILFVFLDFFRITVYPSVRIYLSIYLSIYLSIYLSIYLSQSVQLSVYLFYSVFNIYLSIYLSIYLSICVLISIYLSQYNYLSIYFILFLISIYLYICVLISIYLSKSVQLSIYLFYSVFNIYLFLSLSLYLSIHLCFNIYLSIYLSIYLSIYLSQSVHLSIYLSIYLSIYFILFLISIYLSIYLSIYLPIYLSIYLSIYLSIYLSTYVSPHLFVSIYLPICRSQFVHLSIYLSIYLSIYLSIYLSIYLILFLISIYLSIYLSIYLSVALSLYLSIYLSIFLSIYLSILVCSIYLIYLSIYLYLSIYLFCFFNIYLSIYLSIYLSIYLILFLISIYLSIYLSILFCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D6X5</accession>
    <name>A0A812D6X5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CWF19-like protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SPHA_50554</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Farmed</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CWF19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002993">
        <property type="protein sequence ID" value="CAE1294755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D6X5"/>
    <dbReference type="OrthoDB" id="444325at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061632">
        <property type="term" value="F:RNA lariat debranching enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07380">
        <property type="entry name" value="MPP_CWF19_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040194">
        <property type="entry name" value="Cwf19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006768">
        <property type="entry name" value="Cwf19-like_C_dom-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006767">
        <property type="entry name" value="Cwf19-like_C_dom-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072">
        <property type="entry name" value="CWF19, CELL CYCLE CONTROL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072:SF4">
        <property type="entry name" value="CWF19-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04677">
        <property type="entry name" value="CwfJ_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04676">
        <property type="entry name" value="CwfJ_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="3">
        <location>
            <begin position="6"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="Cwf19-like C-terminal" evidence="5">
        <location>
            <begin position="304"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="Cwf19-like protein C-terminal" evidence="4">
        <location>
            <begin position="408"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="287"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="287"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAE1294755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="498" mass="56622" checksum="1C1D9A44CAFFB423" modified="2021-09-29" version="1">MSAKSLKILVSGDVEGNFKALFSRVSNIEKKNGPFDLLLCVGDFFGENNEEWNKYVQKELKVPISVLILGANQESHCSFYQDKEGAELCHNITYLGRRGMYSGSSGLQIAYLSGTENATCDQISFSQKDVNELIESSTRIQQFKGVDILITSQWAKGIEKYASGADSVDSNKCGSSLISKLALCLRPRYHFVGLQGVFYERQPYRNHQVLQEAAHHVTRYIGLAKVNNVHKKKYLYAFSITPLTAIDYADLTHQPQDVTECPFKLSEMNLQNTLDTDSQQFFFDMQPSKDKGQKRQNDEARNQKKKHKPVQPSGPCWFCLRGDKVEKHLVVSVGETTYLALAKGGLVPDHVLILPIGHYQSTGKATVFFERNYKTSHLQIQVVPVPSEKASNVIDAFQDFALEETLDLNEIPKHSDLKQIVRLESPYFFAEVPTGEKLLCRISKFFPLQFGREVLCSPMLLNIPERVDWRQCNMSEDEEKQNAKDFKKMFRAFDFNFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D875</accession>
    <name>A0A812D875_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SLC2A1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SPHA_50478</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002977">
        <property type="protein sequence ID" value="CAE1294593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D875"/>
    <dbReference type="OrthoDB" id="4540492at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015149">
        <property type="term" value="F:hexose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000029">
        <property type="entry name" value="solute carrier family 2, facilitated glucose transporter member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045263">
        <property type="entry name" value="GLUT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503:SF128">
        <property type="entry name" value="GLUCOSE TRANSPORTER TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="349"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="385"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="416"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAE1294593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="476" mass="52078" checksum="928593B436CFE4B2" modified="2021-09-29" version="1">MGSFTFGYSIAVINSPETIVENFINETVIQRTGVPILASHLRSYWSLIVAIFAIGGMIGGLSAGAWADFFGRKKGMLLNNAIGIAGSMLIGFSKMGSSFEMIIVGRVILGFNCGLTTCLTPMYLSEIAPANIRGALGVVHQLAITIGILMSQIFGFQEILGTKSLWPVLLGLPLAPCIIQLLMLPLCPESPRFLLITKHQETEARAALVTLRGKFDVDLDIEDMKSEQRMCQAEPKISIAQLIVKSSLRKQLVIGIVMQISQQSCGILAILYYSHSLFVSAGMLPNVATHAVSGIGAVMVVMTFISIPLMEYVGRRTLHLTGLMGMFVLSIVMTLALTLNGTVKGMQTVGAITVIFYVAAFSIGPGSIPWLIVAELFPQGSRAPAMSICTMINWLSNFINGFTFPYVQKGLDDLSFVPFTILLLLFWGFTYMYLPETKDKTIEQITDMFRQQQQEKQSKTDGVAKENSYLVGFKKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D9E0</accession>
    <name>A0A812D9E0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_47622</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002595">
        <property type="protein sequence ID" value="CAE1289360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D9E0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="312"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="343"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="373"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="405"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="434"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="467"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="508"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="537"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="566"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="598"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="631"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="658"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="706"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="729"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="759"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="788"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="820"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="854"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="887"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="920"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="959"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="986"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1076"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1114"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1148"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1184"/>
            <end position="1212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1289360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1213" mass="151728" checksum="6E076ED63D1A86E2" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DBC6</accession>
    <name>A0A812DBC6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_50957</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003043">
        <property type="protein sequence ID" value="CAE1295499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DBC6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1295499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="207" mass="23747" checksum="8E3816D280EAC5DC" modified="2021-09-29" version="1">MWSWKKRKRFSFNLVINCFFLFFLVPFILSLIHPPSFSLSISLSFSLSFILSFTHSLSFSLILSLILSLTHSLFLFISFCIDLSHILSLTHSLSLTHSLSLILSLYLFLSHSVSHSLSFFLSHSFSLSLILSLTHFFFRFHSLSLILSHSFSLILSHSLSFSPSLTHSVSFSLTRSFSLSLILPTSSHYLEFIRVKKDEFFFSISLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DDQ5</accession>
    <name>A0A812DDQ5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_51533</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003120">
        <property type="protein sequence ID" value="CAE1296569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DDQ5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1296569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="216" mass="25338" checksum="46A41892F6C920F7" modified="2021-09-29" version="1">MFMSEVGLSINYLERIDIRFLFLIYLSIYLSIYLSIYQSWDLTHNNIMDYSIPKPSSFSILSVYLSIYLSSVHIYLSIYLSIYLSILAYLSIYLSIYLSILACSYLSITIIYLSIYLSIYLSIYLSLFLSIYLSIYLIMLIYICVSDYLSIYLSIYLSILTYSYLSILIFVYLSVYLSLFISIYHSFCISIYLSIYLSIYLSICAYLSTCLSRKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DDV7</accession>
    <name>A0A812DDV7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_50053</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002922">
        <property type="protein sequence ID" value="CAE1293852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DDV7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="307"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="337"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="381"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="437"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="480"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="544"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="687"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="715"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="748"/>
            <end position="773"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1293852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="777" mass="92102" checksum="5A93C9BB07838872" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DEU7</accession>
    <name>A0A812DEU7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">THSD4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SPHA_52781</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003325">
        <property type="protein sequence ID" value="CAE1298785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DEU7"/>
    <dbReference type="OrthoDB" id="5950222at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000005">
        <property type="entry name" value="ADAM metallopeptidase with thrombospondin type 1 motif 9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.830">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050439">
        <property type="entry name" value="ADAMTS_ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010294">
        <property type="entry name" value="ADAMTS_spacer1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010909">
        <property type="entry name" value="PLAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723">
        <property type="entry name" value="ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723:SF281">
        <property type="entry name" value="PAPILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05986">
        <property type="entry name" value="ADAMTS_spacer1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08686">
        <property type="entry name" value="PLAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19030">
        <property type="entry name" value="TSP1_ADAMTS"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50900">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="PLAC" evidence="5">
        <location>
            <begin position="463"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAE1298785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="506" mass="56899" checksum="EDEE2B3EF7AA1FD2" modified="2021-09-29" version="1">MKSSRNFLALKKDDDTYIINGRWPRSSPGQYKASDTVFHYNRHAGKSCVGECLHAQGPIADKLILQLLAYDRNPGIFYEYTIPSGMVPKILHKMKNIRPPPPRQIHPQPQAYSGQFYSQTCGGGTQETRILCVKMNSQVVVTDDNCDPDEKLPTQTTACNTKPCQARWTPSEWSPCSVSCGEGKKTRHVECQEKISPTFSKRVSATVCLNQTRLPTVTKCVEKPCSQWVVKEWSKCSVECGLGHRKREVRCVGADDKVLTDRKCTEPKPTTSDVCDMGSCAKAWFFTEWSKECSASCGHGLLHRKVHCSADNGESLPDNKCKQNTKPKSEKTCKSERPCGGLWFTGPWSECTATCGQGVKVRDVTCVNKLNRNSFTVAEESNCLKEEKPATEELCETLPDCPPEWYTSQWTECSASCGTGSKSRETKCVDANLKQSILCDISERPVTRQSCNTNSCLQIPLNTDPMCRDHMKQCKMVVQARLCPYPYYKQRCCETCRKHYHHHHPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DFI3</accession>
    <name>A0A812DFI3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_54857</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003615">
        <property type="protein sequence ID" value="CAE1302210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DFI3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="326"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="387"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="447"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1302210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="476" mass="58049" checksum="2777AB5FF28F32D4" modified="2021-09-29" version="1">MSYSGEISLLLHVEIPLFPFFFLFFGYWIFCFFSSVFLFLFSFFLILSSSINSYTFFLFFYLFANYQFSFFFFLLLFGLILPVHLFHALLMAFYFYHLHPSFLLFFFSYCLIFSTFSTQVSYIVSFFLIFCHFYFYSKSYIFFLYCQFLPAARFFLPFLTIFLSKYFGISFFLLILYIFLFLASSSLFIFQFSYAFLVFIHSLLFFAFHYFFHIFLFFLVFTYSLFSLHFYSFFKFFILYLYLFFSSHLYFYYSFNFLHSFFYFFPFVHFYLLHFFFFSSFFLLIFFNLIFFSFFSFFLSFFLSFFLSFFLLTICLFVYNSSYYFLSFFLSFFLSSYCLSVHISFYLSFVFLFVLFPHNLFFFFLSFFLSFFLLTVCLSIPHSICPLFFICSFSSQSFLSFFSFLSFFLSFFLSVHTSFYLNRISHLGGILGSQRKRSPEIGKPKLLNYWSFHKLSNLFLLLFLLILRSMAVNEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DHW2</accession>
    <name>A0A812DHW2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_54481</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003537">
        <property type="protein sequence ID" value="CAE1301517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DHW2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="341"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1301517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="398" mass="42926" checksum="5663EB216C4BBE2C" modified="2021-09-29" version="1">MSPLRVTPRRFDVSPPRHTSTICSLSPVSSGCFVLTYSPVISPRFDLSLYPHPHASGPLSPSLSTSPRFVFSFSLSFCPLLHVLISLSPPLNAVLSLLSTTPCFILFLSIPLFVLCPLSVPTLFVHCPLSVPPPLRALSSLCPPPSCFVLSLSPLFVLCPISLSPPLRALSSLCPPPSSCFVLSLSPLSSVCPLSVPLSSCFVLSLSPLFRALSSLCPPLFVLCPLSVPPSPCFVLSLSPPPIFVLCPLSVPPPLRALSSLSPPSSCFVLSLSPPLFVLCPLSVPPPLFVLCPLSVPPLQKTLSSLSPPLRALSSLYLSIYFSMLCSLSLYPLLHAISLPLVYTTHFVFFLSLSSQPLVFYRYPPPHAFFSQSGHLSTYSLFPSLVTSPHFVFSLWRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DI11</accession>
    <name>A0A812DI11_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_56392</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003722">
        <property type="protein sequence ID" value="CAE1303553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DI11"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1303553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="232" mass="28530" checksum="B5353242F89B71C4" modified="2021-09-29" version="1">MHISSPSSLRLENTISMIFLLLLSTCKRKSRWFLSLLFNVFFFKLFFFLFFYLSQFILKLIFSSLFFIFLSYILCFFFLFYYFIFFNFPLFFFFFSHIFYLRCFFFSFFGFVVFFLTFRFVSYPFFGFVVFFFYLFGLLFIFTFASFLSPLLVLFLFLFRFLSLFSHFILFSFPIIFFLSFSPDSLSLSLSLSLSLFLYILFFSLSFFYFPRFRPLSFVFLFFLYYLPLLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DPU6</accession>
    <name>A0A812DPU6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_60478</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004208">
        <property type="protein sequence ID" value="CAE1308614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DPU6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="171"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="220"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1308614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="278" mass="32080" checksum="E826F2C32124FA7C" modified="2021-09-29" version="1">MPIFLSFFLSFFLSFILSFFLSFFLSFLCCFFLSFNVSVFLSTEHISFLCLTFFLSPILLMAAFYFLFFLSFPLSLFSFFPSFFLHFLVYFFFVFLLQVFLFFDFFCIFLSFFLSFFLSFFLSFFLVFSFDAFLLFALNFIHLIFSFFFPLKLSLPFFLSVFTPIFFSPAFFFSFFIFLSLFLFLFSFFLIPNLLFMSGSSSSSSSSSSSSSSPPPPPSSSSSSSSSSSSSSSSSSSSLFYFLIALLSQLLISSLYTFFSAPHYPCQHHSSSYHLPQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DQC1</accession>
    <name>A0A812DQC1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_57870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003920">
        <property type="protein sequence ID" value="CAE1305431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DQC1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1305431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="254" mass="29299" checksum="5220C7176CA217E1" modified="2021-09-29" version="1">MNPSLHSPTSIPAHPLATSHPVVRSAIYHSTTSPKITTDGCLDIYLYFLPFTVSSYLSIYLSIYLSIYLSIYLSICLSLVIIYLSIYLSIYLSIYLSISLSFYICLSILNSISLYIYLDLFISIYLSIYLSIYRDLYLSLFLSACLMLFISISIFSVQFISICSYIYLSQSVSQSIYLSIYLSIYLSIYLSQSIIYLSIYLPISLKSIFEYIKISAFHYLSIYLSIYLSIYLSIYLSIYLSICLSVYEKHIYNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DSE0</accession>
    <name>A0A812DSE0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PTPRN</fullName>
            <ecNumber evidence="4">3.1.3.48</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SPHA_57714</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="4"/>
    <dbReference type="EMBL" id="CAHIKZ030003900">
        <property type="protein sequence ID" value="CAE1305248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DSE0"/>
    <dbReference type="OrthoDB" id="9880441at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030141">
        <property type="term" value="C:secretory granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051046">
        <property type="term" value="P:regulation of secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033522">
        <property type="entry name" value="IA-2/IA-2_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46106">
        <property type="entry name" value="IA-2 PROTEIN TYROSINE PHOSPHATASE, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46106:SF4">
        <property type="entry name" value="IA-2 PROTEIN TYROSINE PHOSPHATASE, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="318"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="349"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="387"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="3">
        <location>
            <begin position="410"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAE1305248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="516" mass="60358" checksum="DB3E75C9BB5C7247" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DT50</accession>
    <name>A0A812DT50_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_58640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004023">
        <property type="protein sequence ID" value="CAE1306391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DT50"/>
    <dbReference type="OrthoDB" id="5835755at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1306391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="160" mass="17733" checksum="DB42F528DE18A591" modified="2021-09-29" version="1">MTIVHLFFSGNLISNISFFFWGNLISNISFWGGEISSAISFFFFGNLINNISFLSGNLINNISFLSGNLINNISFLSGNLINNISFLSGNLINNISFLSEISSIISLFLSKISSIISLFFLEISSIISLFFLEISSIISLFFLEISSIISLFFLEISSTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DW98</accession>
    <name>A0A812DW98_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_63368</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004540">
        <property type="protein sequence ID" value="CAE1312049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DW98"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1312049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="194" mass="21898" checksum="61BF68F0BCFB2F22" modified="2021-09-29" version="1">MGQQVCARMAFPWANICTGMASLLAYIYVSFSFTPPHLLGFLFFSPPPVRFPFLTPPPHIWVSFSLLPTPPVSFSLLHPPPVRFSFFYSTPPPVRFPFFPPPPVRFPFLFQSSVFFFTPPPTCSVSFSLLHPPPVRFPFLYSPHLLGFLSFTPPTCFLFFTPPPPTCSVSFSLLHPPTCSVSFTPPPTCFFFLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DWE1</accession>
    <name>A0A812DWE1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_60319</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004191">
        <property type="protein sequence ID" value="CAE1308456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DWE1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="313"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="337"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1308456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="400" mass="47116" checksum="174628D28BF8E735" modified="2021-09-29" version="1">MHEYAIIISPWLALTIVYVHHGKKSIYLSILISIYLSLFISMYTSIHIYLNLFISIYLYMFFFYLSIYLSIYLSIYLSGPIKNCAFPSFLISIYLSIYLSIYLSIYLSLSIYYHIYLSIYLSIYLLIITDATISIYLSIYLSIYLYLFSHIYLTIYLSIPLYQVSHIYLSIYLSIYLSIYLSIYSSIYSSVSVFSYLSNYLSIYPSISSFSYLSIYLSIYLSIYLSCSTITGISIYLSIYLSIYLSIYLCALPSLSGRCSNTAFALFSLPSLRIGCELFRPSIEQPKPSSVHFCCLVNLFIYNAFILSSRQHFLSFFLSFFLSFFLSFFLSFLNKFIVFFHFFLLLSSPFIYFHSFFPLCLLSFFFLSFFLSFFSSFLFSFFRSFFLQCSSHIYHLYCYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DWM7</accession>
    <name>A0A812DWM7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_63760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004577">
        <property type="protein sequence ID" value="CAE1312525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DWM7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1312525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="249" mass="29904" checksum="6619C5A5B734B698" modified="2021-09-29" version="1">MLRYSFFLSFFLSFFLFFLSFFLFLSTFLPYNSFFLSLFFSLLISLFLSLLPLLCYVILSFLSFFLSFFLSFFLSFVPFYLPSLTLFLSLFFSLLISLFLSLLPTSMLRYSFFLSFFLSFFSFFFLSFVSFLPSLQLFFYHFSFGLLISLFLSLLPLLCYVILSFFLSFFLSFFLSFFLSFLSPSFLTTLFSITFLWFINIFCFFPCFHFYVTLFFLSFFLSFFLSFFLSFFRSFLPSFLTTLFSITFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DX20</accession>
    <name>A0A812DX20_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_61474</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004353">
        <property type="protein sequence ID" value="CAE1309808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DX20"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1309808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="243" mass="27901" checksum="A8F07D73F723DD06" modified="2021-09-29" version="1">MESIYLSIYLSIYLSIYLSIYLSINQTTHTHTHTHTHTHTHTASACYRMLTNHYFCKIFSLFNCSEFVSYSFFFLFNSSCSSESTDVYLHIPTQYTHLFNSIYLSIYLSIYLSIYLSIYLYRWLTSHLIHTPSIYQFISISRTLSLYILSIYLSIKDVQIISSRERERERERERGGCICGSGGTGELAAACGAKQAEPTFLSNAPYAQASRLPAPNGTGGRGFFYLSIYLSIYLSIYLSIYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DXQ5</accession>
    <name>A0A812DXQ5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_61858</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004391">
        <property type="protein sequence ID" value="CAE1310223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DXQ5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1310223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="275" mass="33440" checksum="0048462BD10887CF" modified="2021-09-29" version="1">MSLTLYFFLFHSSPSSSSSSFFFFFFFFFFFFFFFFFLLLLFIIIYKAHFLFSSFFSSIVSGCPLSYSPFLLKRRNDEMSKFSLSFLSFLAFKDFSFRFPLSSIFFPSYFFRRFPSFPFFILIVLFTFCLFFVFFFFCLFIFLSLVFLYFFHSTLLHSHFYFIFSFFLLSFFFSFFIPLSISVFLSLSLSLSCLFSLLPSYLTSLFSHFIYYCLNRHQLPNFFKSSIYFDVISFLYIIFLHYFVIVVLLFHLMLLLHLLFSISLFELFISQNFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DXX9</accession>
    <name>A0A812DXX9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_62336</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004450">
        <property type="protein sequence ID" value="CAE1310822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DXX9"/>
    <dbReference type="OrthoDB" id="6819399at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1310822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="199" mass="23299" checksum="61CDF6389EE78886" modified="2021-09-29" version="1">MMSHIKANFSCLLLKTAELWADRCRIPFFFSVNFCLCPQNALIDLFLHVKGLFISIYHIYLYICLCSYLSNSIHIYLSLFISIYLSNSIHIYLSLFIRLFISIYISNLISIIYLSISLIFISIYLSPFTINIYLSIYLSIYLSIYLSLHLLEKSRLLFNFIIPYRHRVELIIDVRISPPSLSLSYSPFVLQLISTDECL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DZ70</accession>
    <name>A0A812DZ70_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SSD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_63366</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004540">
        <property type="protein sequence ID" value="CAE1312073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DZ70"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35151">
        <property type="entry name" value="ELONGATION FACTOR 1 BETA CENTRAL ACIDIC REGION EUKARYOTE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35151:SF2">
        <property type="entry name" value="ELONGATION FACTOR 1 BETA CENTRAL ACIDIC REGION EUKARYOTE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="385"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="425"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="487"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="519"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="548"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="664"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="728"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="771"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="802"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="841"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="2">
        <location>
            <begin position="204"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1312073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="860" mass="98414" checksum="F2BDB953C180942C" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E1P2</accession>
    <name>A0A812E1P2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_64761</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004671">
        <property type="protein sequence ID" value="CAE1313727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E1P2"/>
    <dbReference type="OrthoDB" id="10583316at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1313727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="197" mass="22903" checksum="30A937B42E38639F" modified="2021-09-29" version="1">MNLSTSVSSIYLYLSPSIYPRLFNLSLSIPVYLSPSLQSISIYPRLFNLSLSIYPRLFNLSLSIYPRLFNLSLSIYPRLFNLSHLSIPRIFNLSLHSIYPRLFNLSLLHSIYLSPSLQSIYLSIYPRLFNLSLSIYPRPFILSIPVPSFYLSIYPSLFNLSIYPSLFNLSIYLSQSLQSIYLSISVSSFYLFIYLLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E1Q8</accession>
    <name>A0A812E1Q8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_65529</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004724">
        <property type="protein sequence ID" value="CAE1314586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E1Q8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1314586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="374" mass="42007" checksum="DC202F7493A6CD27" modified="2021-09-29" version="1">MVIYLNMPIYLYQYTNSSLSLSLSLSLSFSIYLSIYLPDYTNYSSISNAIYLSEYISLKCYLNMLIIHVSIYLSIYLSIYLSIYMPIIYLNIPILFYLFKFFCDLCLPSVTFKLFVSSLFSLSLSLSPSLSLSFSLSLYYSLSLSYSLSLSISYSLSLYLSFLFTLLFFMSLLLSLLLSLSYSLSLYLSFLVSLLSFSLCLSYSLSLSLYIYILSLSPLFSFLFSCVSLTLSLTFSISLSHSLPALPFPVSLSLSLSLSLSTLSSLSFSVSFSHLLSLYISLLSPLSFSVCLSLSLSHLLSLSHLVSLSLFISLLPVSFSMSLSHTYSLSLSLSLSLYSILFPYPTHSSLSFCLFFIPFFFTPGRYAFNNSFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E2C0</accession>
    <name>A0A812E2C0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_63448</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004545">
        <property type="protein sequence ID" value="CAE1312095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E2C0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1312095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="171" mass="20031" checksum="C6F098C3EEC27345" modified="2021-09-29" version="1">MVFCSWFNVMFMLPYFYDDYFIYLLDDMYLSIYLSIYLSIYLSIYYCLSFSFYLSIYLSIYLSIYLSIYLSITVSPYLSITVSPLSIYLSIYLSIYLSIYLSLSLLIYLLLSLLFIYLSIYLSIYLSITVASHLSLSVLICLSIFLSITVSPYLSLSLLIYLSIYLSIYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E397</accession>
    <name>A0A812E397_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_67264</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004870">
        <property type="protein sequence ID" value="CAE1316579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E397"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="266"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="305"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="469"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="512"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1316579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="547" mass="62950" checksum="404B2D7068B7FC88" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E466</accession>
    <name>A0A812E466_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_65954</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004744">
        <property type="protein sequence ID" value="CAE1314953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E466"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1314953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="295" mass="34945" checksum="ED9C95E69F12490F" modified="2021-09-29" version="1">MLSFCRRFFIHSSVPRAYQPMIFPSYSSLYSHPYSSSYSLRISFVFPFVLLFVSLSYFYHILIRIPLCIPIVFSFAFHFVFPSYSHSYSSLYSHHISFLFPFVFLLPFPIVIFFVFPSYSHLYSSSHSSSYFLRIRIRIPLRIPIVFPTYSYSYYSSYCNSFTSPYSHRISIIFSFVFPFVFPFVTLSVFPSYFLYIPIHIPIRIPLRIPISISIRIPLRIPIVFPLYSHSYSSSYSHRIPLRIPIRIPLRIPIIFPIRFSLPFHFIFHSYSRSYSLCIPSVFSIKTILVFSSIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E6K3</accession>
    <name>A0A812E6K3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_67263</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004870">
        <property type="protein sequence ID" value="CAE1316592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E6K3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1316592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="234" mass="27315" checksum="521A372C7F850233" modified="2021-09-29" version="1">MNRVDYHTLSIYLSIYLSIYLSIYLSILRLFISYISQSVRIYLSIYLSIYLSIYLSIYLSISVFSLSIYLSIYLSIYLSILTYQKFRDLYLINFRFLLRLNNRGYAMCNEATKPSSVLSSLSAWLSISVDFYLSIYLSIYLSIYLSIYCIEFSLSLPLSLSLCLSISVGFDLSIYLSIYLSMSVPIYLWIQVQFPSEDTYFIQNFSDIRADISISIYLSIYLSIYLSISIYICI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EC64</accession>
    <name>A0A812EC64_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RRP46</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SPHA_72432</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNase PH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005323">
        <property type="protein sequence ID" value="CAE1322458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EC64"/>
    <dbReference type="OrthoDB" id="27298at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11372">
        <property type="entry name" value="RNase_PH_RRP46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050080">
        <property type="entry name" value="RNase_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953:SF1">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0271">Exosome</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="6">
        <location>
            <begin position="59"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="7">
        <location>
            <begin position="183"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAE1322458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="267" mass="29201" checksum="1B75682218E50F1E" modified="2021-09-29" version="1">MVLFRSSLSELYTSVNTERNAPAADTPQPSNTLDSYTQLRKLADAHQTFTMNGEISNKQLRKVTGELSLLSRSDGSASLCSGDTSMIASVYGPAEVKIAKEQISRATVEVTYRPKSGMPGCNEKLKENIICNTCESVILTCLHPRSSVSLTIQELHHAGSQLACALNVANLALLDANVNMKFMVAAVNCAFTDKGQLILDPTLKEEQAARVTMTFAFDSVSKDILTVYTTGLYTEEEFDTALKACKAASVEIFNFYKEIMQKNLSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EG52</accession>
    <name>A0A812EG52_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_73811</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005396">
        <property type="protein sequence ID" value="CAE1324018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EG52"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="371"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="413"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="447"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="478"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="534"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1324018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="556" mass="67213" checksum="2B4FB42014364F08" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EI37</accession>
    <name>A0A812EI37_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RGL1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SPHA_74060</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005407">
        <property type="protein sequence ID" value="CAE1324272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EI37"/>
    <dbReference type="OrthoDB" id="26687at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00153">
        <property type="entry name" value="RA_RalGDS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00155">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019804">
        <property type="entry name" value="Ras_G-nucl-exch_fac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF312">
        <property type="entry name" value="RAL GUANINE NUCLEOTIDE DISSOCIATION STIMULATOR-LIKE, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00720">
        <property type="entry name" value="RASGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="5">
        <location>
            <begin position="57"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="3">
        <location>
            <begin position="221"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-associating" evidence="4">
        <location>
            <begin position="618"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAE1324272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="728" mass="83846" checksum="449CD7AC5A1918F5" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EJD5</accession>
    <name>A0A812EJD5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_71936</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005273">
        <property type="protein sequence ID" value="CAE1321923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EJD5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039715">
        <property type="entry name" value="ZCCHC10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13491">
        <property type="entry name" value="ZCCHC10 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13491:SF0">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1321923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="238" mass="26465" checksum="D70BE0AD614E1086" modified="2021-09-29" version="1">MDIFSPTTTTTADKLKKIKFPPLLILIKFSLFSSTILHRLFLIIDIFNLNISSSSSSSSSSSSSSSFFTSSSFLFFLRLFLFHLPPPLSSSSFSSPSVLLLLLLLFLIFLSPSSSFSSSPSLFSLLRLYLSHLPFNLSFFLLLELSFSSSFPSFSSSYLCSFSFFLLLSLLLSPLLYPPPLPRHSSSSSSSSSSSSSSFSSPFLLLVFFSLTFREISLKFFTSIECACTFFLLLYVQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EKJ6</accession>
    <name>A0A812EKJ6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_75562</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005464">
        <property type="protein sequence ID" value="CAE1326008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EKJ6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1326008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="261" mass="30594" checksum="B5A6A724CB42DDA2" modified="2021-09-29" version="1">MRSLFHGSWFIRLIHDTCIHLNKSMLLLCLFHSNSTMSSIDEKPLSWFIRLIHDTCIHLNKSMLLLCLFHSNSTMSSIDEKPLSWFIRLIHDTCIHLNKSMLLLCLFHSNSTMSSIDEKPLSWFIRLIHDTCIHLNKSMLLLCLFHSNSTMSSIDEKPLSWFIRLIHDTCIHLNKSMLLLCLFHSNSTMSSIDEKPLSWFIRLIHDTCIHLNKSMLLLCLFHSNSTMSSIDEKPLSWFIRLIHDTCIHLNKSMLLLCLFHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ENX1</accession>
    <name>A0A812ENX1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_78319</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005535">
        <property type="protein sequence ID" value="CAE1328687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ENX1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1328687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="199" mass="24067" checksum="9499F07C0A1EAB74" modified="2021-09-29" version="1">MPKENVGRSFRELSIHTPTHRTIFSRPSYIFSILLILFLSFICSFFLLSIFFFIIFFSSFFRSCFISFILFFTQCFAYFHSYVLSLLRLLFISFDFSFHHLSQLYFLITLIQPFFFPLFVRIFSVCSFLFPISLFSNSFFHLFIISFFLSIFFNLLVHLYLSFISFCIFFYYFLFSFLYSLQFLFPLILTFLSSSSFIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ENZ4</accession>
    <name>A0A812ENZ4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_79508</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005570">
        <property type="protein sequence ID" value="CAE1330176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ENZ4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1330176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="257" mass="28505" checksum="9E4C31796C43AEA0" modified="2021-09-29" version="1">MSKEHEKCAECCSYVLPVEIYPPSLCLSLSPSISFAISLSPSISFAISLSPSISFAISLFFSIAISLSLPLSLLLSLSLFLSPSISFAISLAPSIYFAISLPLSLLLSLSLSLSLYLFCYLSLFLSPSISFAISLFLPLYLFLLSLSLSLYLFLLSLSLFIFSLSFSLLYLFLLSLSLSFYLSPLYLFCYLSPLSLFAPLYFLLSLSPPSISFCYLSPLSLSPSISFAISLSLSPYIYIYIYIYISIYIYIYIYLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EPG8</accession>
    <name>A0A812EPG8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_76939</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005499">
        <property type="protein sequence ID" value="CAE1327470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EPG8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032706705" evidence="2">
        <location>
            <begin position="17"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1327470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="360" mass="40896" checksum="A709D3569711B938" modified="2021-09-29" version="1">MPFFSCLLCFLLKASAMDSTLSILSLSLSLSLSLSLSLSLCLYSYLSISYVHIYLSIYLSIYLSIYLSIYLSMFISIYLSIYLSVCLSIYLSIYISLFVSIYLSIYLYLSIRVYLSIYLNMFIPIYLSVYISMFVSIDRSISVCSYLSKYLSHKLFFEDLKVILPVLLLSLSLSLSRSHFRSFSLSYTGTHARTHTLSLSLFSLPIAFLIFLSLLFLSCSSFHLSLPFPLSFSLCLLLLFTSFHSLSLFRYIYYISFFLSFVLFSLFAYHSSLFCILFSYSCFYSPPFSLSLSLSLSLSLSLSLSFILSVSFGEKKHLSMSIISHSVYTIILTHLDATRLPFAICLSPPPLSPSRGPLNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ERD4</accession>
    <name>A0A812ERD4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_78226</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005532">
        <property type="protein sequence ID" value="CAE1328557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ERD4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="327"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="353"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="385"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1328557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="412" mass="49333" checksum="8BD3C9D95B424381" modified="2021-09-29" version="1">MITCIIIIIIIMIIIIINCFASFLIFLFSIFLSFFDLILLFLFIHFLILFIFYLSFFLSFFFVYIYFFFSFFDILTVLFSFFLSFFLSFFLFSMYLKFYLICYRILLSSASLLSPFFPEKFKRLLFVCLFVSVFLSFFLSFFLSVCFILNHISFLFPVSFHFFLSFFLSFFLSFFRYNSYYECAYIFPFSCFFSFLSFFLSFFLTFFRYNSYYECACVCLRGLLFCQCEFVCTIYLSIYLSIYLSIYLSISVCFFLSIHPSIYLSLFLSIHPSIYLSVFLSIYLSIYLSIYLSIYLSQSVFFYLSQSVSIYLSIYLSIYLSIYLSDLSIFLSISIYLSIYLSFSIYLSLFLSIYLSLFLSIYLSIYLSIYLSIYLSIYLSISVCFFLSISICFYLSIYLSIYLSIYLSLFIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ETU9</accession>
    <name>A0A812ETU9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_80243</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005595">
        <property type="protein sequence ID" value="CAE1330975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ETU9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="328"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1330975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="437" mass="48175" checksum="03A5C56F613C07C2" modified="2021-09-29" version="1">MSPSLLLSRILSSLFFFLPSFLLFLLLSLFLFFCLISLLFIIAYSLPLFSSSTLLFPLLLPNLPSLLLSRILSSLFLLVLSLFPLLLPNLPFSLIIAYSLPLFSSTLSSFLLFCVIFPSLLLSRYSLPLFSSSSLSFLFFLPNLPSLFLSRILSLSFLLALSLFPLLLPNLPFSLIIAYSLPLFSSILSLFPLLLPNLPFSLIIAYSLPLFSSTLSLFPLLLPNVPFSLFIAYSLPLFSSSTLPLSSSFATLPLSSSFCLISPFSLIIAYSLPLFSSSTLPSFLFFCLISPSLLLSPSPSFLLLLPNLPFSLIIAYSLLSFLLHSPSFLFFCLISPSLLLSRILSLSFLLVLSLFPPLLPNLPFSLIIAYSLLLFSSSTLPLSSSFATLPLSSSFAQSPLLSYYRVFSPSLFSCTLPLSCILYLQLPSIHPLLTSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EWA2</accession>
    <name>A0A812EWA2_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Leucine-rich repeat-containing protein 43</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SPHA_80539</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005601">
        <property type="protein sequence ID" value="CAE1331339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EWA2"/>
    <dbReference type="OrthoDB" id="433501at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454:SF19">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454">
        <property type="entry name" value="NISCHARIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14580">
        <property type="entry name" value="LRR_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52075">
        <property type="entry name" value="Outer arm dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="513"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="616"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="522"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="554"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="626"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAE1331339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="691" mass="78061" checksum="7A6A4FC6FBD3A912" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EXD4</accession>
    <name>A0A812EXD4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_80479</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005599">
        <property type="protein sequence ID" value="CAE1331199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EXD4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1331199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="167" mass="18556" checksum="F421B92F58D66D7F" modified="2021-09-29" version="1">MALTLAHISVTHSHLSLPLSLSLSLSLPLSLSLSLSLSLLFPLFFVLVLPIYFYLFFIPDFLHLSLSLSLSLSLSLSFVHTHTRSHAQLLNLHDCLHLPLRLSSLLTPSLLTPSLLSLSLPPCSISSKSFLLTYFLLLITLPLASFLHPSLHCPYLSPTYTRIRPET</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AMI5</accession>
    <name>A0A812AMI5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_1815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000052">
        <property type="protein sequence ID" value="CAE1146383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AMI5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1146383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="158" mass="18390" checksum="1024DC5B76B72C8B" modified="2021-09-29" version="1">MLSIYLSIYLSIYLSIYLSSSVSQCIHYLSIYLSIYLSIYLSIYLRRSLNEFTIYLSIYLSIYLSIFVGLSMNSLSIYLSIYLSIYLSIYLRRSLNESPSSIYSFIYLLRSLNIAHSVRIYLSTSVRRSLSLFICSLSIIYLSIYLSIYLSNYLSILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AMI9</accession>
    <name>A0A812AMI9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_1052</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000029">
        <property type="protein sequence ID" value="CAE1142542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AMI9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34723:SF7">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34723">
        <property type="entry name" value="PROTEIN CBG17025"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="338"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="443"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="470"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="502"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="529"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="585"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1142542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="659" mass="74652" checksum="C6BC5678C6AD8A8F" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812APT4</accession>
    <name>A0A812APT4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_2501</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000069">
        <property type="protein sequence ID" value="CAE1148568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812APT4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="328"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="359"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="388"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="501"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="532"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="560"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="588"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="621"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1148568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="644" mass="74547" checksum="AD4DCAC004F6FF9F" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AQH2</accession>
    <name>A0A812AQH2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_3123</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Lophotrochozoa</taxon>
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            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
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            <taxon>Acanthosepion</taxon>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000091">
        <property type="protein sequence ID" value="CAE1151389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AQH2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1151389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="205" mass="23949" checksum="C5E16CA0C412FA6B" modified="2021-09-29" version="1">MYVLSLEDMGCFLIIYYRSFVETEKCTAKCQNVEETGIGTFFISRSLIHTVPRVRLFFFALSFLSYFLSRSYSLTFLSTLSLSYFSIIFKHFFLHSLSLSLSLSHLSQANLIVFPYYSAILHSPYCYYRFSHLAMTFFLFFHIHFPSSSLSLSLSLSQSLSLRLPFPIENFPFISRYCSLSHLVITFYLSIYLSIYLSIYLSISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ARJ4</accession>
    <name>A0A812ARJ4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GPR141</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_4211</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000131">
        <property type="protein sequence ID" value="CAE1154439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ARJ4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1154439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="171" mass="20592" checksum="F7F7C5B03C95225F" modified="2021-09-29" version="1">MPLVHISISAYLYLYHISSIYLSIYLSQLFIYIHLSIHLSIILSIYLCSFSIYSIPFISIYATCSYLYLIYSYSSISIYLFIHPSIIHLSLSFIIYFFFFLSIHPSIHLSISIFFSFFPFIHSFIIPFIYLSIFFFFFHIYPFIIHLSIYYFFFLSFFLSIYISIYLFINI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AS55</accession>
    <name>A0A812AS55_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_5753</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000189">
        <property type="protein sequence ID" value="CAE1158950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AS55"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1158950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="168" mass="20054" checksum="CCA3306C9EE01617" modified="2021-09-29" version="1">MKKEVSSFFFFVFVAVTNSIFFFLSISFFFSFFLSLFYLLSFFSFFLHIFTFLPFFKVFLSFFLLNLCPPTVFSFFLSFFLSFFLSFFLCSNFAIMNDLLSEKLNSLKFFTIYLSIYLSIYLSIYLSDQSIYLSIYLSIYLSIYLSIYLSDQSIYLSIYLSIYLSVEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AV31</accession>
    <name>A0A812AV31_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_4384</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000138">
        <property type="protein sequence ID" value="CAE1155066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AV31"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1155066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="271" mass="32075" checksum="E3EA4C2A7439622B" modified="2021-09-29" version="1">MIIYLSIYLSIYLSYVCIYLSIYLSIYLSIALCIYLSIYLSIYLSIYLSVSLLFICTAYNTIYLSIYLSIYLSIYLSMSVFIYLSIYLSIYLSIYLSLFIIYLFRSIYLSIYLSIYPSLFISIYLSIYLSIYLSIPVFSYLSIYLSIYLSIYLSIYLILFLSITLTKSFYIYLSISISIFHTLFSFCLSQFFVSIYLFLLSFSLSLSMFISFFLSHAFFIFSHAFFLSFFLSFVVSFYLSNYLSHAFILSFFLFCFLSCFLSFFVYTVYVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AV54</accession>
    <name>A0A812AV54_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_5237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000174">
        <property type="protein sequence ID" value="CAE1157470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AV54"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1157470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="208" mass="23850" checksum="DFD35BAE9888407D" modified="2021-09-29" version="1">MFVSILSLTSKFSFSRSLSQRFSLFSYNRICFLSRSHSVIVSLSLSFSLCHCFSLSLSFSLCHCFSLSLSFSLCHCFSLSLSFSLCHCFSLSFVLALRFSRTRSPSLPFCLNHSHSLIKLLTIINSLAHSVSLVNSLSRTHFLSMIFFYFSFSFFCLFFSISLYLFLSFSSLHFSHSLFIFAPLFQSLLFFVFSFLCFLSPFLFASPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AVE5</accession>
    <name>A0A812AVE5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_4923</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000161">
        <property type="protein sequence ID" value="CAE1156771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AVE5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="244"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="327"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="360"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="393"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="419"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="446"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="485"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="519"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="546"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="589"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1156771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="612" mass="71256" checksum="F397B9A67C8BCBDC" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AW96</accession>
    <name>A0A812AW96_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_6440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000211">
        <property type="protein sequence ID" value="CAE1160503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AW96"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1160503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="211" mass="25363" checksum="F185E3946C263CBB" modified="2021-09-29" version="1">MKFYSFLSLSLSLSLYLSIYLSIPLFIYVNLVSISLYIYQSKSVHIYLNIYIICSFLSIYLSIYLSLYIYIICSFLSIYLSLCIYDLFISIYLSLSLYIYMICSFLSIYLSIYLYNLFISIYLYLYRYIYNLFISIYLSIYLSIYLSISIYIYIICSFLSIYLSLYIYMICSFLSIYLSIYLSIYLSISLYIYIYNLFISIYLSLSLYIYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AXW8</accession>
    <name>A0A812AXW8_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UMOD/GP2/OIT3-like D8C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SPHA_9005</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000290">
        <property type="protein sequence ID" value="CAE1166701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AXW8"/>
    <dbReference type="OrthoDB" id="382013at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057774">
        <property type="entry name" value="D8C_UMOD/GP2/OIT3-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23283">
        <property type="entry name" value="D8C_UMOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="414"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="UMOD/GP2/OIT3-like D8C" evidence="4">
        <location>
            <begin position="79"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAE1166701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="561" mass="62695" checksum="ADC4E445F0062BE4" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AY13</accession>
    <name>A0A812AY13_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_7849</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000254">
        <property type="protein sequence ID" value="CAE1163906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AY13"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1163906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="267" mass="30236" checksum="1BD291EBC34E58D4" modified="2021-09-29" version="1">MSFQEYLSIYTSIYLSIYLSIYLSIYLSLTYRSSSSSSSSSSSSSSIYMYHAYLCSIYHSVFISIYLSIYLSIYLSIYLSIYLSITVSSYLSIYLSIYLSIYLSIYLSITVPSYLSIYLSITVSSYLSIYLSIYLSIYLSIYLIVSMFISLSLSYSFSFFLSFFLSFFLSFFLFSFLFFLSAFLSLSSSVSLASTYLIFASPSRTDWNKEVVRSTAADRFLATAGARHSRGALRASGDGEQRRRRAVGSGRRCPRLSSALGSLPHIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AYS6</accession>
    <name>A0A812AYS6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_9503</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000302">
        <property type="protein sequence ID" value="CAE1167546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AYS6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1167546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="430" mass="47941" checksum="B53810AFD5D70601" modified="2021-09-29" version="1">MVRCSAHFCLVYIYVKDSYLVPYPAVAFPDSECNVSHYPRCLSLGYGEYLSWLLSLSLYLTPNIWLLLSLTPSICNPLSVLTFITPSISLCAYFHYTLYLAVRLLSLHPLSNLYLLCFHYTLYLLSYFSLHPLYLAVLTFITPSICCAVLSLHPSLLTLIHSIFHYTPSIWHNTYFLPSIYTLYLSVRCFHYTSICTMLLSLHLYLGCLYLLSLPPICCPLSAVCLFSFVLLFPPPVPLFPPPRCALTSVSYFPQAVRSFLFPPPLFPPLAVHFYSPPSVLPVPPLAVLTSVPPLAVRSLFPPPRCVNSFYSPPRCALTSIPPSLITHFLFPPPSSHFCSPPAVRSLLFPPPPVHSLLFPPPPLTISPPPCCKLLPVPPPPPVPPLSVRSLLFPLSVRSRSLLFPPLSVLTSVVPHLPLSLHLLTSPTHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B092</accession>
    <name>A0A812B092_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_8717</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000284">
        <property type="protein sequence ID" value="CAE1166116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B092"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1166116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="263" mass="29603" checksum="2735125CC68AF1A4" modified="2021-09-29" version="1">MNQNLKTIQFRSFNRFKYLFSFHSFVAFFIPFLIPSSPLSLSFSLSLSLSLFLPFSFTLSLSFSLLPYFPLSFFLTLFLSFSFTLPRSRSLSFPISLSIFLPHSLSVSLSFSLSLSLSLSLSRSHSLFFPISLSIFLPLYLSISLSLTHTHTHLDFNHRIFQFSCNLTIHKCCFLEHSLSHHLSLSPSLSLPLYLSLSASLPLSLPPFLSHSPTTSLSFSLSPSISLSISSLSLSPFLYLAISIYLSLYFPISLQVISKCLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B0Q3</accession>
    <name>A0A812B0Q3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_7910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000256">
        <property type="protein sequence ID" value="CAE1164089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B0Q3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1164089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="151" mass="17277" checksum="A6F1C5C14F8B49E4" modified="2021-09-29" version="1">MAFFFFFTTCIQSTDIVSSTQPDPIGSCKEGYQPNLATLSVRIGIQLNTESIYLSIYLSIYLSIYLSIYLSHVVYWNITLRPSSYLIFLLLIYHHLLLLQSQSLHALSQLPLLVVSPIVSRDERIPFRKKKSCLHCLSPLMFTPFSSHSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B2B4</accession>
    <name>A0A812B2B4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_10035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000322">
        <property type="protein sequence ID" value="CAE1168433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B2B4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1168433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="247" mass="29036" checksum="DFA91BF53E4BE58F" modified="2021-09-29" version="1">MYFITIFKSIYLSIYLSICLSICICSFCSYLTVLISICRFLSIYQSIDLSTIYCNLFISVIHSLFKSIYLSIYLSIYLSIYLSIYLHMFVLFISIYLSIYLSVLSIYLSIYLSLFISISVCSYLSICSIYLSIYLSIYLSIYLSIYLSQSVHIYLSIYLNISVCSLSISIYLSLYLSIYLIYSISVCFSYLFIYFYLSIYLSIYLSIYLSQSVHIYLSQLVHNFLSLYVYIYLSIYLSIYLSIYQQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B2U6</accession>
    <name>A0A812B2U6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NOTCH1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_8225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000266">
        <property type="protein sequence ID" value="CAE1164887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B2U6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="312"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1164887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="441" mass="49992" checksum="FF8A5FA308641E23" modified="2021-09-29" version="1">MSSAMMLPFAIPATHENFDGPFQENRSFSLQINDGKCDTEIRSSVSLYTIFFHFVFLLYLFLSFSLQLLLLSFFFLPFRFFYFFSSFPLLFHFLLVFLLHFFFSILSPFFFYSSVSFPSFFFSLTSSSKNSFEQKTLNFFQIIPFPYPANTSLTLSLSLSLSLSLSLSLSLSLFLSFSFSLSPSLSLPLPISLPLSLSLSLPLSPSPSLSLSLSLSPSLSPSLSPSLSLSFSLFLSPNSFNECIFSFFLFLSVAFFFSLFFFDTYTLSSFFLSSSFHNSLTISRTHTYYMFPSFFSFLLLFIPFSLSLSIYLSIYLSLSLSVILFSGANSVSFFKFYHSLSLSLSLSLTPHSSHTHTHTHTHTVLFFFHSSFFHNSHSLLLSNGHILHFSFFFSFTHTHTYSASFSLFQNIAAHMPEVILSTYLVNIPAPVPSLKRQTASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B630</accession>
    <name>A0A812B630_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_12041</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000402">
        <property type="protein sequence ID" value="CAE1172481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1517790at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050836">
        <property type="entry name" value="SDS22/Internalin_LRR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46652">
        <property type="entry name" value="LEUCINE-RICH REPEAT AND IQ DOMAIN-CONTAINING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46652:SF3">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14580">
        <property type="entry name" value="LRR_9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1172481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1432" mass="163194" checksum="66425626B3F13A4D" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B6T6</accession>
    <name>A0A812B6T6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_14024</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000474">
        <property type="protein sequence ID" value="CAE1176127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B6T6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="327"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="361"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="395"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="442"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1176127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="481" mass="57960" checksum="AF4AF55E8D39469F" modified="2021-09-29" version="1">MFLKHDGTASGIHLMAASSRETFLNVFLKSCYIFLLLSFYPSFFLISRHSFSFISLPLNFLFFFLCFVYFFLLPSFGFLYFLCRLQFLYFFLESHVISSFTFVSFLLTIFFLSYFLFPFSYYSFLSFSSCLQFLSFFCILIAILFFLFLLLFFSFFSFLLTITFFLYNPFFLSFFSILIAILFFLFLFFYLIKICFLFLPSFLSFPFTYLFFSFFSFLLTISFVLFHSFALFSFFLSFFLLHYYSFPFLFFLAYNFFLSDSFFLSFSFSVILFLLSFLLPYFFFLLHSFSFFLFSFSISFLFSFLSFFQFISLSFPFSYFLNSLISYLFKIAFSFFFSFFLSFFLSFSFFLSFFLSFSFPFSYFGVGGFLSLISYFFKISTFFFFFLFHSRVFNFVLSFFSFLLLFLSLAYPFFVISFYFSFFPLFSSLLTFSLSLSNLNPFFYFSLSFCFLFYFFYLLIISHFSPSLSSFALSFVVYFLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B8Q6</accession>
    <name>A0A812B8Q6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_12209</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000406">
        <property type="protein sequence ID" value="CAE1172677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B8Q6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1172677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="286" mass="33440" checksum="53C5CCEA8A3DC9ED" modified="2021-09-29" version="1">MCTSIISFPSIYSYLSIYLSIYLSIYLSRCVPFYMFSVFHLLTINLIPLFSLFFSIRKGLSLLLTDKPIHIFLIHIQSIPIFPAFSPPLFPSFFNIDRTFPYFIYSFSQAFFVFCPPSHILKEAEKQCVDFVNAFFIVLFVFRATFSLPIYPVRHCLVIVRALSQRHSTGNTSQAAMSLLQASVFHIYLSIYLNLFIIYIGSYLSIYLSIYFIFILFVNFSIYLSIYLSIYLSLFISISKEKILLPHVQERIYLSIHLSISVYSYLSIYLSIYQSREKMMSIYLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BC54</accession>
    <name>A0A812BC54_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_14673</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000502">
        <property type="protein sequence ID" value="CAE1177455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BC54"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1177455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="235" mass="27618" checksum="9F4E17C443079A30" modified="2021-09-29" version="1">MSNLSISSLSLNLSSCESPSLFTYDSQPLLASTLSLFIYLSIYLSIYLSIYLQANITINLRCLFSEVAEVVGAQHFQLSYKTLLRRNTSAVMREREAQSRSCLCAIYHHVFGEIWALNICEKVQNFFFFDVLLSFIFSFFLSFFLSFFLCNLIIPRLYYFNVNFSVYFLFCFRFHTFLSLFFLSFFLSFFLSFFLSLQFMYQLHRMYVFNQILLPMPTYGPQAASLIQQLVLHSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BCV3</accession>
    <name>A0A812BCV3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_15985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000558">
        <property type="protein sequence ID" value="CAE1226383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BCV3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1226383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="251" mass="29528" checksum="77A05117F664B0B1" modified="2021-09-29" version="1">MYLSMYLSQSIHIYLSICIFISISSILSIYLSIYLSQSIINSYYLSIYLSPSISMYLSTYLSVFIYVCRTISLYSYLLQYNRIYLSIYLSIYLSSIYLSIYLSIYLSISVYTYLSIYLSLYISIYLSIYLSIYLSQSIHIYLSISVYTYLSMYLSQSIHIYLCIYLSLYISIYLSQSIHIYLSEIYSYLSIYLSIYLVYSIYLSIYLSIDFNLNISIFSPYLSIYLSIYLSIYLSIYLSISVCSVCSYLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BIF0</accession>
    <name>A0A812BIF0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_19293</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000700">
        <property type="protein sequence ID" value="CAE1234183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BIF0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="310"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1234183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="335" mass="37327" checksum="8C81BBE2D8729752" modified="2021-09-29" version="1">MYSSSSSSFSDLTPSLFSPLSLYLYLSLHFYIPVISLSLSFSLSLSLTLSKYSFFLSLSFSFSLFVSVFMFLCPKLSLSHSLSLSLSLSITHFLSFLSLRICLLSGYVADFALSSTLPLPFSLSAYLYLFLFLCVPDLSLSPLSLSPLSLSLTLFLSFSLLHSTSLFFALCLSIFLFVSPYVFLISLSLSLTLPLSFSLSDYLYLFLFLCVPDISLSPLSLSNTLSYFLSLRICLYVSLYISLISLSVTLYLSLFRSLPIYISFCFSLCVPDLSLSPLSLSNSFFLSFFLSLSSYLPLSFYLSLFRSLPIYISFCFSLCVPDLSLTLSLTLSLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BKW4</accession>
    <name>A0A812BKW4_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SPHA_22310</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000824">
        <property type="protein sequence ID" value="CAE1240398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BKW4"/>
    <dbReference type="OrthoDB" id="10029564at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002142">
        <property type="term" value="C:stereocilia ankle link complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032426">
        <property type="term" value="C:stereocilium tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051844">
        <property type="entry name" value="USH2_Complex_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23116">
        <property type="entry name" value="PDZ DOMAIN CONTAINING WHIRLIN AND HARMONIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23116:SF29">
        <property type="entry name" value="PDZ DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PDZ" evidence="4">
        <location>
            <begin position="93"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAE1240398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="190" mass="21112" checksum="4658441E4C872180" modified="2021-09-29" version="1">MVITKTANHTFSFSSDRASSFVLSYPVLYDGQWTPQLLLRQSLPVVTRVPKVNRPMGTSCSGRSGFFCDKHIETKEEKEKRLRKKYGNIPLQEVIIYKTMPTLGLAFEGGATSRQMLPRVVSIQSNGSTFHSHTALQVGSILLEVNNSSLVGIQHSEVAASIANAFLDETSDYMKFLITEPGWEIKIGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BPZ2</accession>
    <name>A0A812BPZ2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_20679</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000759">
        <property type="protein sequence ID" value="CAE1237259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BPZ2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1237259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="392" mass="45315" checksum="ECD85700B9320F84" modified="2021-09-29" version="1">MNTHALYVCIHTQIYLSIYLSIYLSIYLSIYLYIYIYIRTNLLSSKRPFCCAIHSIDKTRSNIFSCAIHSIDKTRSNIFSCGIHIIDKTRSNIFSCAIHSIDKTRSNIFSCAIHSIDKTRSNIFSCAIHSIDKTRSIIFSCAIHSIDKNSFKYFSCAIHSIDKTRSNIFLAPYISLTKLVQIFFLCHTFHRQNSFKYFFLRHTFHRQNSFKYFSCAIHSIDKTRSNIFLAPYIPSTKLVQIFFLAPYIPSTKLVQIFFLAPYIPSTKLVQIFFLAPYIPSTKLVQIFFLAPYIPSTKLVQIFFLAPYIPSTKLVQIFFLAPFIPSTKLVQIFFLAPYIPSTKLVQIFFLAPYIPSTKLVQIFFLAPYIPSTKLVQIGFVVLYITSTQLVQLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BQ52</accession>
    <name>A0A812BQ52_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">polynucleotide adenylyltransferase</fullName>
            <ecNumber evidence="2">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SPHA_20753</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Farmed</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>RNA(n) + ATP = RNA(n)-3'-adenine ribonucleotide + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11332"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17347"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="ChEBI" id="CHEBI:173115"/>
            <dbReference type="EC" id="2.7.7.19"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:11333"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TENT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="2"/>
    <dbReference type="EMBL" id="CAHIKZ030000762">
        <property type="protein sequence ID" value="CAE1237419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BQ52"/>
    <dbReference type="OrthoDB" id="10065073at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048255">
        <property type="term" value="P:mRNA stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012937">
        <property type="entry name" value="TET5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12974:SF36">
        <property type="entry name" value="POLYNUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12974">
        <property type="entry name" value="PRION-LIKE- Q/N-RICH -DOMAIN-BEARING PROTEIN PROTEIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07984">
        <property type="entry name" value="NTP_transf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01153">
        <property type="entry name" value="DUF1693"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="111"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="111"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAE1237419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="649" mass="73605" checksum="3AE1419988BA6ECC" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BRP2</accession>
    <name>A0A812BRP2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_20961</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000768">
        <property type="protein sequence ID" value="CAE1237786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BRP2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1237786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="152" mass="17881" checksum="77A40AF25EBF9EF0" modified="2021-09-29" version="1">MLDRGVVNGETEVNEWQMLFPTPPFSFISTYFRLFHFFSFINFSFLFFFCLLFHSSFYMCFCLSFDFLFLSFFLSSFLPSFLPSFFLSFFLSFFHSFFLSFFLSVSFLSFFFTFVSIYALYLISCPLFNASSQTSPSSAFFLLSSAPIWDGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BSV2</accession>
    <name>A0A812BSV2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MSH6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_22109</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000814">
        <property type="protein sequence ID" value="CAE1240065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BSV2"/>
    <dbReference type="OrthoDB" id="10252754at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05837">
        <property type="entry name" value="PWWP_MSH6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000313">
        <property type="entry name" value="PWWP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042778">
        <property type="entry name" value="ZCWPW1/ZCWPW2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15999">
        <property type="entry name" value="ZINC FINGER CW-TYPE PWWP DOMAIN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15999:SF2">
        <property type="entry name" value="ZINC FINGER CW-TYPE PWWP DOMAIN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00855">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00293">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50812">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PWWP" evidence="2">
        <location>
            <begin position="57"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1240065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="450" mass="50418" checksum="D95A1DF563D3DEF6" modified="2021-09-29" version="1">MSKVNTLFAYFSKTPKKTEDSQVLSPKNNTKSKTSNGTPDAGKQHSKNGDIPQEFSVGDVVWSKLEGYPWWPSLVCNHPTTNTHLKKGKVPEVHVQFFDDPVSRAWVKAKFVRSFTGADSKEARTGGTYFSMDPAQRKGVTGADKAMKMSKEERLGLVVELQPSEDEDEMKDLDNMFDESMSEEDDSEKSKENVNIEKSPKESKSKESPKKTPKKGTRRSERSKPKRRRIIVESDSDSGDSADEYKVPTKSGSEEEEEEEDDDDDSLSSGVDEEELSEPESASEPEPSPVKRKSIGSSSTPKNSSFVASLGSATKSKLSLFSAPESNSSGGAGDASEGSTTYLHQTLDFLKPEKIKDINGRSPDHPEYDQRTLYIPESFKSKVTPAMRQWWDLKSKHYDTILFFKVGKFYELFHMDAFIGVKELGLIYMKVSRFLCFCFLCENCSCFCLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BTF3</accession>
    <name>A0A812BTF3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_21390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000784">
        <property type="protein sequence ID" value="CAE1238602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BTF3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1238602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="177" mass="20718" checksum="8C87269F6D42D4ED" modified="2021-09-29" version="1">MWKGVFLSFTHFPFFSLSCFLFSLFLLLYTVQLQHGPAATEIYTFFFSLDFSFLSSNTGCILSVRISWRLLSFSHALHLIFIYLSIYLSIYLSTRSLICLSVSIYDNFFRLCVCMRSIPSHDIPIYLPFSVFFFSQIHTSVLMKITEAYSFFSFCFTSNCTYISMLEEILYHAYLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BUN1</accession>
    <name>A0A812BUN1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_23937</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000888">
        <property type="protein sequence ID" value="CAE1243674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BUN1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1243674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="320" mass="37619" checksum="75C562B733B76FA2" modified="2021-09-29" version="1">MILPFKIPTVIKCLWAAISKSLHVYSHVKLFFLSFFLFLLDSILIVVCFLFFRKSISSFLSLPGLHKESFISLYSFFLDSMKSLVCLLLFLKAINFFLSFFLSGWTPYRHWFVFSFRKSSFSSTLLISGLHYHLHILFRVLLLLFSLPLKHHDQNTPATILLHHFLFVHNYQSITFCSFTSINQSLSIRSHLSINHFLFVHIYQSITFYLFTSINQSHSICSHLSITFCSLTPINHFLFVNTYQSITFYSFVFINQPLSIRSYLSSNHFLFVHIHQSTTFYSFTSINQPLSIRSHPSINHFLFVHIHQSLSIRSYLFLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BUV6</accession>
    <name>A0A812BUV6_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GTP-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SPHA_23174</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Farmed</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Promotes degradation of target mRNA species. Plays a role in the regulation of circadian mRNA stability. Binds GTP and has GTPase activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000857">
        <property type="protein sequence ID" value="CAE1242033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BUV6"/>
    <dbReference type="OrthoDB" id="248233at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04165">
        <property type="entry name" value="GTPBP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03694">
        <property type="entry name" value="GTPBP_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03708">
        <property type="entry name" value="GTPBP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000028">
        <property type="entry name" value="GTP-binding protein 1,-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000014">
        <property type="entry name" value="Probable GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000091">
        <property type="entry name" value="Probable GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050055">
        <property type="entry name" value="EF-Tu_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035531">
        <property type="entry name" value="GTPBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721">
        <property type="entry name" value="ELONGATION FACTOR TU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721:SF9">
        <property type="entry name" value="GTP-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="681"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="712"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="738"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="766"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="797"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="837"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="863"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="891"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="983"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="domain" description="Tr-type G" evidence="10">
        <location>
            <begin position="132"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="542"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="564"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="601"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAE1242033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1003" mass="117177" checksum="3BF610EFABBC0A73" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BXA1</accession>
    <name>A0A812BXA1_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_24639</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000922">
        <property type="protein sequence ID" value="CAE1245220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BXA1"/>
    <dbReference type="OrthoDB" id="8010572at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF20">
        <property type="entry name" value="REVERSE TRANSCRIPTASE-LIKE PROTEIN WITH RNA-DIRECTED DNA POLYMERASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1245220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="208" mass="23819" checksum="4B198BE45B40732B" modified="2021-09-29" version="1">MEVDGMPAKLLRLIKVYYRSTRNRVRAYGEESETFEVKTGVRQGCALSPALFNYTIDYILGKALSGLRGSCGWMEYERRAEVVATFRVKKKPAEVMVWFGFKRSMVMDIWRKWKACENKDEFIAKQKAHNVRFSAVRTDKFVTAAKETVGNDGSQSYVKIAADMGCHKSTIYRKINKDNGYSSYCKYHRMLITNASSVHQTLSTGRVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C7Q0</accession>
    <name>A0A812C7Q0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_31613</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001302">
        <property type="protein sequence ID" value="CAE1259282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C7Q0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1259282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="173" mass="19459" checksum="D00B8660BDC2588D" modified="2021-09-29" version="1">MSLLSNASAQCFLSFPLCFRILSLFFHFIIPPLSVSLIFYLTHLIPPPRSSSSSSSSSSSSSSDADFLFPSSFSPFFFSFYFSSSSFSSFFKILLLLLLLLLLYSKIFNFSLSFFHTLSNSPYSPLFLSNPNMTSPISAIYIYSLLFSASYLSEFSVKSIYLSIYLSIYLSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C902</accession>
    <name>A0A812C902_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_34897</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001491">
        <property type="protein sequence ID" value="CAE1265860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C902"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="273"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1265860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="303" mass="36846" checksum="D6E35F5FCF8CE1BB" modified="2021-09-29" version="1">MLSVKNWLPRQKPLHLPHLDKQRFFFLSFSLCYFPPRFASFLRFANTFSHDFFCWINSFLSLSLSLSLSLSLSLHCFYGFLHFKLFLSFFLSFFLSFFLSLVISLVLSSLFIWVLFLEYILSFLSRFHSLHISLSFLFFCYFSLRYFFSFLDMIHYFFLFFFSCLQYFFSSFLFSLMIFLHSYFSSLSFTFLLFVFCYRLAYFFLSFCFSYLFFALFCGYLLLPVFFFFIYTSIFLLLSYISSTFFYSFFHFIFLPPITSVLIIPSFSPLKEYLVITYISFLTVSHDFTFTFTFTFYFVHFYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C9I9</accession>
    <name>A0A812C9I9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_31911</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001324">
        <property type="protein sequence ID" value="CAE1259913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C9I9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1259913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="292" mass="35658" checksum="92F856F339FBB513" modified="2021-09-29" version="1">MFFPLFFRCFSFIILLYFFPLLFDSILFSLDFSCCLRIFYSSFLALFSFRFASVSSPFPRCRRLRLLSPWFRPAADEISFRYLFEVNIFIVYFFFFFSYLLFFLSFHHPRYILCRLLFFISFFLCNFPFFQVRFFLSFFSPFSIYFMYDVFTFKISFVLPFLPNFPILNPLCLFVFSFLTFFRPFSFVLSFLSTFSFLSSQLLSFFFLSFSFFLLSFVFSFFLCFIRYFFHFFTILNIFRARTFLLQSFFLSFFLSFFLSFFLSFFCTVFFTLFALFKAYKPKLHSIAVTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C9Z7</accession>
    <name>A0A812C9Z7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_31072</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001262">
        <property type="protein sequence ID" value="CAE1258106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C9Z7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="287"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1258106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="312" mass="37069" checksum="7559F17AE4C075F3" modified="2021-09-29" version="1">MSELCIRTAFAFPNFLLLSLLLSIHNYLRLIITLASNKSYLSIYLSIYLSIYSHLSFKDILHISFFLSFFLSFFLSIYLSIYLSHTSLQYSFLLFWIPSFFFSFLSIYLSIYLSIYLLIECLNSIYSHFFFSSLIFSCIIIIIIIIFFFFFFFFFFFFFFFSLFKPFLFVTPSLYLSSYLYLLVFSVAFMPILLGLTFFILNFAFLSFLGNFFSLSHAFIVSYHPLIYVLTFIWEFLCQSNSFSVNPLLNCSPFSSFFVNLSIYLSIYLSIYLSIHLSIYLSIYLSLSFFLSLSLYIYIYIYFYFIAYILAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CBC4</accession>
    <name>A0A812CBC4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_30330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001218">
        <property type="protein sequence ID" value="CAE1256667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CBC4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="334"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="370"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="409"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="454"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="484"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1256667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="512" mass="61035" checksum="73F2522098978412" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CCM4</accession>
    <name>A0A812CCM4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_31016</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001258">
        <property type="protein sequence ID" value="CAE1258004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CCM4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1258004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="272" mass="31205" checksum="8225857248724CCE" modified="2021-09-29" version="1">MKIFFFLSFFISSFPSLFVSLFPSLFVSSFPSLFISTFPSFFISTFPSFFVSSFLSFFLFPPLLLSFCFLLSIFLFVSSFPSLFLFPPFPLSLFPPFPLSLFPPFHLSLFPSFFVSFFPSLFVSSFPSLSVSAFPSFFISSFPSLFVSFFLCFLLSFSLCFLLSLFLCFLLSLFLFVSSFPSLFLFPPVPLSLFPPFHLSLFPPFHLSLFPSFFVSFFPSVFVSSFPSFFVSSFLSFFLFPPFPLSFCFLLSLSLCFLLSLFLCFLLPTFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CF04</accession>
    <name>A0A812CF04_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_34054</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001435">
        <property type="protein sequence ID" value="CAE1264128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CF04"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039715">
        <property type="entry name" value="ZCCHC10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13491">
        <property type="entry name" value="ZCCHC10 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13491:SF0">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="319"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="364"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="428"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="512"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1264128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="531" mass="61880" checksum="C16C3A573D3580A7" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CFM1</accession>
    <name>A0A812CFM1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_35124</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001510">
        <property type="protein sequence ID" value="CAE1266310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CFM1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="323"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="387"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="420"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1266310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="536" mass="64592" checksum="00C86ACC748B2E09" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CHP0</accession>
    <name>A0A812CHP0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_36234</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001580">
        <property type="protein sequence ID" value="CAE1268728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CHP0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1268728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="257" mass="30724" checksum="54542C52B2709AC7" modified="2021-09-29" version="1">MSSISSSSPLYHNSLSFLIYLVLHFTFPPYLSSLHFPNLPFSFSRLPVIFSTPLRYVSSFTSFSPQFHFSITNLLYNVFFLIQFHFSFTLSFFLSFFLSFFLSFFFPIIFFLFLDHPRQLSSLFSFCILFFSLSLFITSLFYFLIVSFYMFLVSSLLPSSHCLLHSIFTSLLPLHHFPLFFLSFFLSFFLSFFLSFFLSMTCFFVFFSHCCYLFLYIKINRSFFPFSFTFLFFFTLIIFSFFTSLICFLCSLYFKHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CHU9</accession>
    <name>A0A812CHU9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NrdD</fullName>
            <ecNumber evidence="2">1.1.98.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_37276</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.98.6" evidence="2"/>
    <dbReference type="EMBL" id="CAHIKZ030001661">
        <property type="protein sequence ID" value="CAE1271570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CHU9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1271570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="258" mass="29025" checksum="FF26E352523620F4" modified="2021-09-29" version="1">MFFVDIFFPNIISIHFLSRHILPRDIVSRHIVSRHILLRHILFKHILSRHILSRPTRSYTAALLAPASSSGTFSLLCNALPPLSIQQLSSPLSPSFSLRLNRPGALRFLACALIASRCSCNACEYLCLLAPPTTIAKKNIDICHSFFLSFFLSFFLSHALSLSIYLGYSLSLSLLTFVFDVCTSISSAHRSLSLSLSLSLFFFNIFLTPSVPVTPLTFSVTVLFFFLFPILPLTLSFSPSFQFFHFSIEIFNFLSQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CLL8</accession>
    <name>A0A812CLL8_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PWWP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_36038</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001561">
        <property type="protein sequence ID" value="CAE1268302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CLL8"/>
    <dbReference type="OrthoDB" id="10013064at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05162">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06080">
        <property type="entry name" value="PWWP_MUM1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035504">
        <property type="entry name" value="MUM1-like_PWWP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000313">
        <property type="entry name" value="PWWP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00855">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00293">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50812">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PWWP" evidence="2">
        <location>
            <begin position="32"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="PWWP" evidence="2">
        <location>
            <begin position="374"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="482"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1268302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="594" mass="66986" checksum="753706C2451E221F" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CMP6</accession>
    <name>A0A812CMP6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_38450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001746">
        <property type="protein sequence ID" value="CAE1273792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CMP6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="358"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1273792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="407" mass="47073" checksum="DB238C18C8649CD0" modified="2021-09-29" version="1">MSLHVLLFLLLLSCLYLNPGISLSTFYLSIYLSIYLSIYLSIYLSIVVLAYLSQLFIYLSIYLSIYLSIYLSIYRSPGISLSTFYLSIYLSIYLSIYLSIVVLAYLSQLFIYLSIYRSPGISLSTFYLSIYLSIYLSIYLSIYLSNSSSIYLSIVYLAYLSHLFIVVYISLIFLSIYLSIYLSIFLSILSISLIFYLSIYLSIVSYLSISSTYLSIYLSIYRSPGISLSTFIYLSIYRIYLSLSTFPGYLSIYQSIIYLSISIVVLAYLSQLLSIYLSIYLSIYLSIYLSIVVLAYLSQLFIYHLSIYLSIYLSIYLSIYLSIYRSPGISLSTFYLSIYLSIYLSIYLSYPISLNLYLVLYLSISSIFYLSIYLSYSFSLIFLSIYLSIYRNVRAEFTHGNAILHKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CSQ8</accession>
    <name>A0A812CSQ8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="13">TIM10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SPHA_44115</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Farmed</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small Tim family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002236">
        <property type="protein sequence ID" value="CAE1283518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CSQ8"/>
    <dbReference type="OrthoDB" id="274922at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11038">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11038:SF16">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0811">Translocation</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Tim10-like" evidence="12">
        <location>
            <begin position="15"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAE1283518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="208" mass="23590" checksum="A4A6E8B573B02D2A" modified="2021-09-29" version="1">MAVNVNEEQMKLVFELEMEMMADMYNRMASSCQKKCIPPRYNDSELNKGEAVCLDRCVAKFLEVHDQVVIFLFLSPSLSIYFSLLFLSLSSLLSTLSFSLFPSLYSLFLSFSLSPFLSLPFLSLSFLSSLLSTLSFSLFPSLYSFFLSLPFSLLFLSLSSLLSTLSFSLFPSLHSFFPSFYLPHLVLSLSLSFYLLLSFCLSLSLFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CUA1</accession>
    <name>A0A812CUA1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SFRS12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SPHA_40735</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001935">
        <property type="protein sequence ID" value="CAE1277579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CUA1"/>
    <dbReference type="OrthoDB" id="7763451at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12260">
        <property type="entry name" value="RRM2_SREK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12259">
        <property type="entry name" value="RRM_SRSF11_SREK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000084">
        <property type="entry name" value="Serine/arginine-rich splicing factor 11 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034192">
        <property type="entry name" value="SREK1_RRM2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32343:SF22">
        <property type="entry name" value="LD29830P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32343">
        <property type="entry name" value="SERINE/ARGININE-RICH SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="14"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="169"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="279"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="287"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="370"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="387"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="469"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="483"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="522"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="547"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="558"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="625"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAE1277579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="648" mass="72979" checksum="DEA3CC6C8F38EA47" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CV31</accession>
    <name>A0A812CV31_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_43761</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002218">
        <property type="protein sequence ID" value="CAE1282993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CV31"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1282993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="236" mass="27799" checksum="CDC9AD60E706B9A5" modified="2021-09-29" version="1">MIPHLKNSDQNQFDIFSFLFSFQPSVNYPTGRKKTNSWQATQGTDQWQGQGVAIYKTDKRNRCRRFCLLLLLLLLAALFSALAAFVCYYFLQPGLDLFKFTMTYLKRSDALSIYLSIFYLNIYIYLSIFHIYLIYHINLLFYSSMYLFQNIYLSIYLSIYLSIYLCILSINLSNLSGLFISIFSYISQSVQIYVSAFISIYRFLCIHIYLSIYLSIYLSIYLHSSYVPQKSAHFNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CWU1</accession>
    <name>A0A812CWU1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_43334</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002168">
        <property type="protein sequence ID" value="CAE1282245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CWU1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1282245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="202" mass="22554" checksum="FE5ABAC7BD7BF5DD" modified="2021-09-29" version="1">MCFFEKNSQEEEPRNHIEVTEKEKSPSPTPAVESKFQPSSSTIVIPCSSPSSAHAPSHQPTHPQPPPPQPPPPPVHPAPPPAHTAPIVSPSRASIQATISAGVSLPPQTIEHVRWASSEMPAGVWRFRANNGEQADNPISDDQCSNFILIEKERLAVEKQRLQVEKGRLDIEEKRLQMERRRFKIEKRRFQIEEALYLSGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CWX0</accession>
    <name>A0A812CWX0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_44776</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002290">
        <property type="protein sequence ID" value="CAE1284455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CWX0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1284455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="343" mass="41106" checksum="BF02D37C2DC42E1C" modified="2021-09-29" version="1">MSFFFLSFFRSFFLFLFFISFVPTFQVFPFFTIYFLNRSFFLNPFFYVFTVENHCIDSIFDTLRQNLFDSSYALLSRSPPPSIYFSLSRSPPPSLYFSLSRSPPPSLYFSLSLSPLSQSLSLPLSIFSLSLTYEFYTLTTFIFFLENIYLNLPLSHSFFDSFLSFLIPIDLSIYLSIYLSIYLSIYLSAFLFQYFKIAFFIFLNIPQLSLSRPLSHSLSLSLSENSFSLFSISFTHSKSRSFHFIFSLLSFFLSFFLSFFLSFSPSYLSFFFRRFSFLLALFFFYFFYFFFSFLSLFSFFNVVTLFWIRSFFHFFFSFIFKRIVFNLCFCLKFTISWCLFYSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CWZ4</accession>
    <name>A0A812CWZ4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_41373</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001981">
        <property type="protein sequence ID" value="CAE1278615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CWZ4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1278615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="215" mass="26950" checksum="F5C1BF15D760FBEA" modified="2021-09-29" version="1">MQNIPCSYEFVADKRKEHFIALRWHRLVNMKREMEKRPKNTNSVIFFLSFFLYFFSFFLSFFLSFFLSFSFLSLFLSFIFLSLNILFFFLFFLFSFFSFFLSFFLSFFSLFFFLSHLLLSKIFFKMYKFHLVKIFFFLSFFSFFLSFFFLFCFFFFFIFSLISFFLSFFLSFFYTRLFCSSFFCDFSYLFCLFFFLSFSFFLSFLNFFLSFFLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D076</accession>
    <name>A0A812D076_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_45013</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002319">
        <property type="protein sequence ID" value="CAE1284893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D076"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="341"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="366"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="393"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="425"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="456"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="493"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="552"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="588"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1284893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="607" mass="73671" checksum="07BDB6A39C7CE152" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D0U2</accession>
    <name>A0A812D0U2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_45432</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002340">
        <property type="protein sequence ID" value="CAE1285439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D0U2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1285439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="153" mass="17940" checksum="FCBF96FD16A06C0D" modified="2021-09-29" version="1">MPLASPLFNGLHLICFRLLFQFHWLCNPLQESKWIVAVTFCHLSILLRSSPVRNLSRKRRTHVRRICRSLFSSTCSSLCFSSFLKYISQNHSSSSSLTYSFCSLFAPHVFLYDYIYLPIYFFFLDNLFFSSLFLASFVMLLFPSLILHFSAFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D1W6</accession>
    <name>A0A812D1W6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_47862</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002634">
        <property type="protein sequence ID" value="CAE1289839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D1W6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="315"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="340"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="363"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="426"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="453"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="483"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="507"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="532"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="563"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="595"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="621"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1289839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="672" mass="78147" checksum="4FF382BF164516A1" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D2G8</accession>
    <name>A0A812D2G8_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">WSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SPHA_46289</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002445">
        <property type="protein sequence ID" value="CAE1287013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D2G8"/>
    <dbReference type="OrthoDB" id="6091680at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051836">
        <property type="entry name" value="Kremen_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24269">
        <property type="entry name" value="KREMEN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24269:SF16">
        <property type="entry name" value="PROTEIN SLG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="548"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="9">
        <location>
            <begin position="328"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="8">
        <location>
            <begin position="422"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAE1287013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="641" mass="74102" checksum="9CEA73ED0AD46191" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D2N5</accession>
    <name>A0A812D2N5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_48927</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002766">
        <property type="protein sequence ID" value="CAE1291774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D2N5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1291774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="171" mass="19004" checksum="93F942B5CF1164AB" modified="2021-09-29" version="1">MPLPSFPPLLPPLPFPPLIPPPSFPPLLPPPRFLPLLHPPSFPPLVAPLSFPPLLPPPPLLFFQLPPPFPPFLPLRFIAILPPPSSSPLPAPPPFLLLPPPSFHLLRLHPSFILLRPPPTFPPFLPPPRFLPLLPPLSFPPLVLPPPFPLLLIQQRTGRILLRREPICPKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D6R8</accession>
    <name>A0A812D6R8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_49716</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002877">
        <property type="protein sequence ID" value="CAE1293232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D6R8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="310"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="371"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="408"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="451"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1293232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="469" mass="58573" checksum="CFF9D9362363C86B" modified="2021-09-29" version="1">MFFQHFLFLFFSFFLSSVFFFLSFFLSFFLPFLSFFTSFFLFFFLSFFCVFNFFLSCFLFLFIFKLFFSFFLSFFLSFFLSFIIMFIFLSFFLSSFLSFLHYSLFCFCFFYCFSSFSVYFKKFFLSSVSTVSFFLSFFLSFFLPFHSFFLLRYFSTFFFSFLSFFFLFLSFFLSFFVTHLSFSFFYCFSSFFVYFNIFFFFLSFFLFSFFISFIIMFIFLSFCFPFFHSYTILFFVFVSFIAFLPFLSISKNSFFLSFFLLFVYLFFLSFSLAFFHSPKFSFFLSFFLSFFLSFFCISIYFYLFIFLSFILIFFSFLFFYLLMLFFFFFCVVPNFFFSKFFFFLSFFLSFFLSFFLSFYHRRFSHRFLSFFLSFFLSFFLFPKFSFLSFLSFFLSFFLSFFLPSPGSYFFSFFFCFFFHQIFFLSFFLSFFLSFFLSFFLSFYHRRFSHRFLSFFLSFFLSFFLSFFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D800</accession>
    <name>A0A812D800_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_46871</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002506">
        <property type="protein sequence ID" value="CAE1287986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D800"/>
    <dbReference type="OrthoDB" id="8069108at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1287986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="721" mass="69319" checksum="E3DD5F60EC28A7E8" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D831</accession>
    <name>A0A812D831_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_50427</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002966">
        <property type="protein sequence ID" value="CAE1294482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D831"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1294482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="250" mass="28116" checksum="657674408D8AD9EB" modified="2021-09-29" version="1">MNPYGVFIKSCRPRSLSVSVNRNSPILRPLHTLLYLLFISFPRLSLSLSLSLSLSLLSLSNIVRYFYLCLASLSFRTNITPFSLSLSLSLSLTHSLTLSLSLLSPLSQTSASTSFSPLSFSLSPSLTRPISSPFSISHYQHPFLFILFSPSISLFLVLSFSMFDIFLHLKAPFLTIFLTLSFFSLLLYLLHFPPFSFFFHSPLAVLISFLLTSLFLPYKLMTYPFTCLFLSISLPLSISPNFTFSLPLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D9N1</accession>
    <name>A0A812D9N1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_48380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002688">
        <property type="protein sequence ID" value="CAE1290776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D9N1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="95"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="295"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="375"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="421"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="451"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="477"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="508"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="567"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="591"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="621"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="654"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="694"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="718"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="745"/>
            <end position="762"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1290776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="764" mass="92456" checksum="5B8D24DFDFA57A71" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DC40</accession>
    <name>A0A812DC40_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_50045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002922">
        <property type="protein sequence ID" value="CAE1293880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DC40"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="387"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="427"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1293880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="466" mass="54406" checksum="BB65FE0817A3F5B6" modified="2021-09-29" version="1">MYSGQKFPAFSCLTFSYSKSVRLCGRKPLAILVTVWPTLSFIEMRAMLRSQGSLLCPTLSLSLSLSLSLSLSLSLCFYINNVLFPFRSKYFSSSFRLQILFHFTLQRLLSFPFSPKTPFFSFPSKDSSLFLPLQRLLSFPFSPKTPFFSFPSKDSSLFLPLQRLLSFPFPPKTPLFSFPSKDSFLFLFQRLFFPSKDSFLFLSLKRLLSFLFPPKTFPCPSKDSFLFFLPSKDSFLFLSIQRLPLQRLLFFPFSFPHPKTPFFSFLFFSSKDSFLFLSIQRLLSFPFPPKTPFFSFPSKDSFLFFSLQRLLSFLVHPKTPFFSFPSKDSFLFPPKTPFFSCPSKDSFLFLPLQRLLSFLFPPKTPFFSFPSKDSLISASSKCTFLPFPLYISIYTSFLLAAFLHLQNDPFLFPSKYCLFFILLLQKAFLYPPPLRFFSFYIVVYFLRLQKDVPFLHLQVVLLFLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DCS1</accession>
    <name>A0A812DCS1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_53511</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003413">
        <property type="protein sequence ID" value="CAE1299942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DCS1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1299942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="175" mass="20050" checksum="4E502194BCEDA4A2" modified="2021-09-29" version="1">MCHPPCCLPLISFIMICSPIHQCAILHVAFLNFIYYDLLRFINVPSSMFLPLILFIMMVPSSLPLNFIYYDLLSDSSMCHPPWCLPLNFIYYDLLSDSSMCHPPCCPSLNFIYYDLLSDSSMCHPPPCCLPLNFIYYDLLSDSSMCHPPCCLPLIFIYYDLLSDSSMCHPPCCLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DD04</accession>
    <name>A0A812DD04_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_51824</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003164">
        <property type="protein sequence ID" value="CAE1297085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DD04"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1297085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="167" mass="19712" checksum="4F475B65E51CA71F" modified="2021-09-29" version="1">MKERVSLFLVPSLQHFSLATCISLLRFLPRFHYFKESGFFSLSLIPSKISSMTCVFSLSLIPLNIHYFINDVCFSFLIPSLFHYCIHDFHYFIHVMCFSLSLIPISRYLYFSLFDSFLDSIISFRRVFLSFLDYVEKIISASFSLDSFLHHDVIPYKIHIFLFSILP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DGB7</accession>
    <name>A0A812DGB7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">LBX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SPHA_54828</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003604">
        <property type="protein sequence ID" value="CAE1302147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DGB7"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990837">
        <property type="term" value="F:sequence-specific double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000098">
        <property type="entry name" value="Transcription factor LBX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000047">
        <property type="entry name" value="HTH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051892">
        <property type="entry name" value="LBX_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24336:SF8">
        <property type="entry name" value="LADYBIRD EARLY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24336">
        <property type="entry name" value="TRANSCRIPTION FACTOR LBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00031">
        <property type="entry name" value="HTHREPRESSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="11">
        <location>
            <begin position="99"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="101"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="146"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAE1302147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="216" mass="25216" checksum="7D75D9E860CA3B6D" modified="2021-09-29" version="1">MWVYLLRFGASTYFDDRRSIFDTHKYPCRDQLFNVAIIIGGILSEASVSLLFYHRLHIPRCSLALFSLAVQYNMSESVRYVNAKRREQAALFGKHQPPKKRRKSRTAFTNQQIYELEKRFLYQKYLTPADRDEIALSLGLTNAQVITWFQNRRAKLKRDLEEMKNDVEHAKVVTPQLNNLLVKTLVKKSLECDSLSQQPIIEDEEESHSKDNSVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DI74</accession>
    <name>A0A812DI74_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_52783</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003325">
        <property type="protein sequence ID" value="CAE1298749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DI74"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1298749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="198" mass="22232" checksum="3D5246E27F88A91E" modified="2021-09-29" version="1">MKIVTLSPLLSFSLSLSPSFSFSLSLSLSLSLFLSRLHIFLSIYLSVTIIKIFTYLSVCLSIYLSIYLFIALTLYLYLSIYLSIYLSIYLSIYLSIPLTCTCLNSPGSNEPYCLVIGDRLAGEIHIWTSSEILRDGPNSLDTHLCRQGTNILDTHLCRQGPNFLDAHLCRQGPNFLDAHLCRQGPNFLDAHLCRQGPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DK61</accession>
    <name>A0A812DK61_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_56473</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003723">
        <property type="protein sequence ID" value="CAE1303630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DK61"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="392"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="457"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="486"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="516"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="542"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="573"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="606"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="638"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1303630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="665" mass="77604" checksum="346818F097FB36AA" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DNG9</accession>
    <name>A0A812DNG9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_58322</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003979">
        <property type="protein sequence ID" value="CAE1305990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DNG9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="322"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1305990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="370" mass="42799" checksum="081BC66458ED2F35" modified="2021-09-29" version="1">MLFLGKNQYSISIYLSIYLSIYLSIYLSQFSSHPSYLSIYLSILSIHLSIYPSILFSSSIHPIYLSIHIHPSIHLSPISILFSSIYPIYPSRNLSSIYLKHQSIHLSIYLSIYLSIHLSIYPIYLHHPFHHPSIYPSIHPSIHPSIHLSQFFSKSTHHLSIQKNLLIYLSIYLSISSIYLSIHQFSSSSIYLSQSPLSQFHLSIISSIYISIYLSISSISYISIYISFIIYLSIYLSIYLSISILSHHLSIYLQSSHHLSIYLSIYSSIYLSISILFSSIYLSIYLSIYLSIYLSISILFSSIYLSIYLSIYLSIYLSILRIIILCPPISLFFFSSFLCLRLSFPSIFRSLFSYLPPFLTFFLISICFFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DPE9</accession>
    <name>A0A812DPE9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_57776</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003908">
        <property type="protein sequence ID" value="CAE1305294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DPE9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1305294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="265" mass="30837" checksum="8A30D6AE2FEAB8C2" modified="2021-09-29" version="1">MRYFLSFLSLVFFFISRDGCDRRSFVLWSGLGRLTAFFHSFPFSLSLSHYLSCTLFIFSFFIHSFIHSFIHSFFLSFSSFLFLSFFLFTTLSTTLSPISSLSISYLLFFLPENISFFLSFFLSFFLSFFLSFFLSLTLSVYLYVIYYFSCPRILFLSFFLSFFLSFFLSFFLSFFHMYLLSNMCFLPETLFFSISVSHYLSLYLSVSVPVPVSVSVCLSVSVALSLIFNIFLSFSLHLSLSLSLSLSHHHVVSASHFPILFSLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DTE4</accession>
    <name>A0A812DTE4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_58275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003973">
        <property type="protein sequence ID" value="CAE1305907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DTE4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1305907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="181" mass="21580" checksum="FF07C1FBFF1AD0D8" modified="2021-09-29" version="1">MSTFINVSQKNSLEGIEKILFFPIHRPPFETILSFFRFLSFFFLSFSFILFLSFFFFLSFFLALHFSCFFLSLRVYLDSFFLFPFFLRLTLFFLSFFFLVLSFLSLLLFLFLFSLCQSGFFLSLYLLISFLYCCVSLACFFLCIFLFFFLSFLLSFSVSHSLLSFLSLSLISNFHAFFTFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DU74</accession>
    <name>A0A812DU74_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_59991</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004155">
        <property type="protein sequence ID" value="CAE1307957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DU74"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="321"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1307957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="360" mass="40524" checksum="17C72B3B12DF294B" modified="2021-09-29" version="1">MKLRKGAKYNSSRNEFLLYLSTIRERKGKETCLLSLSQIFSFLSLSLSLSLSLSLSLSQISPNSIDTFNCVERKGKKPFFSFSLSLSKSNSIDPFNCKLDLFSLSLSPNQIALIRLTGENSIDSSVLSCVKANSICFNRRKKRKRNLPFLSLSLSKSNSIDPKKRKRNLPFLSLSLSLSPNLIALIRLTGENSIDSSVLSCVKANSICFNRRKKRKRNLPFLSLSPNLIALIRLTANSICFNLPFFSLSLSLSLSPNLIALIRLTGENSIDSSVLSCIKANSICFNRRKKRKRNLPFLSLSKSNSIDTFNTGELPLMLLDFLFVLFLFLLLFFSFLLFFLMSLFVLSELHTAQKTAPSQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DUW3</accession>
    <name>A0A812DUW3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_62979</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004513">
        <property type="protein sequence ID" value="CAE1311596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DUW3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="297"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="321"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="349"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="376"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1311596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="409" mass="48100" checksum="FC55E61FEBA37BD2" modified="2021-09-29" version="1">MYHLCNRLFHLFTFLLLQHLSIYLSIYLSLSVHNYLSQSVPIYLSIYLSIYLSIYLSIYLFVCLSIILCHIYLSLMFFISIYLSIYLSIYLSIYLSIYLSIYLSIYPFLFITIYLSLFLSIYLSIYLSIYLSISFCPYLSIYLSIYLSIYLSVCLSYWSYLSISYVVHIYLSIYLSIYLSIYLSICLSVCLSIILVIFIYLLCCSYLSIYLSIYLSVCLFVCLSYWSYLSISYVVHIYLSIYLSIYLSIYLSICLSVRLSIILVIFIYLLCCSYLSIYLSIYLSIYLFVCSSVYHTGHIYLSLMLFISIYLSIYLSIYLSIYLSICLSVCLSIILVIFIYLLCCSYLSIYLSIYLSIYLSIYLFVCSSVYHTGHIYLSLMLFISIYLSIYLSIYLSIYLSIYVSYTIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DV77</accession>
    <name>A0A812DV77_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_59178</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004103">
        <property type="protein sequence ID" value="CAE1307099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DV77"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1307099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="312" mass="36715" checksum="B7D15D1618ACE672" modified="2021-09-29" version="1">MHCCSYLFQSIRIYPSIYLSIYLSIYLSIYLSFHLFLCIYLGLFISIYLFISTCIYLFQLKSVHNVQRLLWKIECIYKPFILFHLSIYLSIYLSIYRCLLICSLSLSLYLSIYLSIYVSNFLPISIYLSIYLSIYLSITSKKEIILLLIIIIIISPPFLFHFVLFASFFFFTISLFSFLFSTYSHLTPPFSSSSYSSSSFFFVFIFSTPAVFFFYFSCFTVSFHSYSSPPPPPPPSSFYSSSHYYYYYYSHRVSCFLFQLFSSRLSFHLLSLLVLFLTSLFTAYLYVSLLLPLAFSSRPNLVRRCLHLLLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DVB8</accession>
    <name>A0A812DVB8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_59806</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004146">
        <property type="protein sequence ID" value="CAE1307780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DVB8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1307780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="158" mass="17344" checksum="11FA24ECAFF1F884" modified="2021-09-29" version="1">MSAPTALSTSSKISPSFRPPAISLPLGNPSHLFYSDTLISLSHLTCDHHTLISLLFSLHSITRYSFADTRTRDLPPISNLLFFISSLPNLLSSCVTPPHPTPNSTTLPHLHIVFVFFLSYGLPLPLNLNVSNRHPFLSFSHGFSNPLPPPLPSPSFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DW51</accession>
    <name>A0A812DW51_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_59655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004126">
        <property type="protein sequence ID" value="CAE1307609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DW51"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="310"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="340"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="377"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="408"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1307609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="440" mass="52434" checksum="83FAFD5366B2448E" modified="2021-09-29" version="1">MSSILTAGYAAVAYFFLFLSFFPLLSFLFLSFLSFPFPFFLSFFFLSFPLLSSLPFLFLSFSFSFSFFSFSFPNEFLLSFLSFFLSFLFLWSKLFLFLFLSFPLLSFPSFLSFLSFFFFFLFSFFFLFLFLSFSFPLLSFLFFLFPFFSFLFLFLSVSFLFLPFPFLFLSPPFFFLFFSSLFFFFLFLLSFFLSFLLSFFSLLSLPFSFPSHSPFSFSFPFPFLSFPLLSFLSFLFPFLFLFFSFSFQFLSFLFFLSLPFLSFPLLSFSFSFVFLLPFLSFFFSFLLSFPLLSFSFSFFSFSFPFFSSSFFPFLFLSFLLLSFPFLSFPFPFLSFPLLSFLSFLFLSFPFPFLSFPFPFLSFPLLSFPSFPFFSSPFLFLFFLFLFLSFLFLFFLSLPFLFLSFPFPFLSFPFPFLSFPLLFFSFLLKDATISAMSLFPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DWC5</accession>
    <name>A0A812DWC5_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Calcyclin-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SPHA_62750</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Farmed</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004489">
        <property type="protein sequence ID" value="CAE1311277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DWC5"/>
    <dbReference type="OrthoDB" id="164025at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044548">
        <property type="term" value="F:S100 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06468">
        <property type="entry name" value="p23_CacyBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.790:FF:000040">
        <property type="entry name" value="Calcyclin binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.10">
        <property type="entry name" value="UVR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037201">
        <property type="entry name" value="CacyBP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052289">
        <property type="entry name" value="Calcyclin-binding_UBL-bridge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037893">
        <property type="entry name" value="CS_CacyBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007699">
        <property type="entry name" value="SGS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015120">
        <property type="entry name" value="Siah-Interact_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13164:SF3">
        <property type="entry name" value="CALCYCLIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13164">
        <property type="entry name" value="CALICYLIN BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09032">
        <property type="entry name" value="Siah-Interact_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140106">
        <property type="entry name" value="Calcyclin-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51048">
        <property type="entry name" value="SGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="CS" evidence="13">
        <location>
            <begin position="67"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="SGS" evidence="12">
        <location>
            <begin position="145"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="28"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="175"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAE1311277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="221" mass="25643" checksum="FC2A24199138E265" modified="2021-09-29" version="1">MARSVADVKKDVEEMEMLVSESKRSHVKEILQIELRKLQIELSKLMTEGDETKTKSTVKTTPNCPTVSLTNYAWDQSNKYMKIYIDLKNVHNLPKEKITCNFEAKSMNLTVYDLDNRNYRFGVKRLAGTIVPSESFFKIKTDSLVIMMMKQSNTNWEHVTEMAAEKSKEKTKKKPTLDDSKDPSEGIMDILKNIYEEGDDDMKRTINQAWYESRNKTSSFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DWE6</accession>
    <name>A0A812DWE6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_61746</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004385">
        <property type="protein sequence ID" value="CAE1310130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DWE6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1310130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="238" mass="28943" checksum="F6D45C097F030023" modified="2021-09-29" version="1">MPFSIGSFFSIYLFFISYLCFSSLFSFNFLFLLPYHNHILYCSTLSRVTILFSFLLYSFFIVTLSLFTSSSFFHLSVYTPSDTFIFQFYFCNTISIYLSIYLSIYLSIYLSIYTLRFYQHVYNIVSIVTFFVTLVSFFMSSVDFIFPIFYLFFSFFIFATFLDFFLSYLSLLFIIICYYVFFYTYCLFLFFKHILFSFFCSFFILSYIHIFFFLYCLLYNRQIQFVCIYPHICVDIFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DZH0</accession>
    <name>A0A812DZH0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_65343</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004715">
        <property type="protein sequence ID" value="CAE1314381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DZH0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1314381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="190" mass="22055" checksum="38BC3E313E53D6D0" modified="2021-09-29" version="1">MSVSAGIDKKKSLHWIGFLCFSFGLCEKVTVIKQRYFIYPYLSIYLSQSSIYLSIYLSIYLSIYLSIYLSMRVHACNRWLPQLAHFFRSTMTPNEVFQGRESASCLSIYLSIYLSIYLSIYLSIYYHIPETFDHIHQSSEEKVINRSQISLLTINMLVGISTNDPHFLVSSPDTICKLSCLTFTRFTELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E0B9</accession>
    <name>A0A812E0B9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_64866</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004677">
        <property type="protein sequence ID" value="CAE1313794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E0B9"/>
    <dbReference type="OrthoDB" id="10062692at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1313794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="476" mass="52567" checksum="8525CEABB2A70FF1" modified="2021-09-29" version="1">MRSGLADDIQQIDDARKTAVIDRELSRLGNDIACLQETRLADSDIPRSRHWYQLDLVITRREDLRIVLHTGSFHSADCDTDHSLVGCKVRLTAKRIDCSKTKGLPLINSCRANDPGSSRRFQTTFSAKVDTSSFSATDIDSRWHHLCDAIYTSALTAFVKKDRRNAGWYEAHWDEMKPVSEAKRQALLAYKHNPCVNTRDALRVARSRAQQTARGCANNYWLNLCSTIQTSADSGNARGMYTGIKTATGITPITTAPLKSKTGEVITDRGKQLERWVEHYLELYETQNMVTDAALDALPSLPVMEELDAPSSAEEHGKAIDCLSCGRAPGRDGIPSEFLKSGKPALLNNSTRSCTCTGRRTTPSETCEMPTLSPSASSGKSLPASSCHACRVSPPEKNTSRTHSIAMADGLEVTVYKRIHYFTGCLYDKQSSRSSSLYTSPSLFPYCLSLIPDISLNHPSELLNYVCTFIITSPVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E119</accession>
    <name>A0A812E119_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_62420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004461">
        <property type="protein sequence ID" value="CAE1310910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E119"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="318"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1310910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="349" mass="42852" checksum="B843AE4A534C970B" modified="2021-09-29" version="1">MLVLTPTKPFHFRDASNTFCFRFSVCSLPAQIFSFRINHIFLFLSFTVFPFFLYSCHSFLFLPSPSFFFPLSDYHSLLFFFLTYILRSFFHFPFVFLLSLHYFHAFSIYHFLLNFFYCHFSFYFSNFFIFEFFFFFSFHLQFSFLFYFSFYFLFHPFYYSSSFLLLILPLFVHFVFLALCFLFSFLLTFFPDLYFLSLFLFFFFFTHLIYSFSILPFLLFILSFYPLVILASFFLTAFLSFLLPFFLSYRLSFFLFSFLQPVFSYVFISLSRLFFFSFFPSFDYNILIRFRFFLLLFLLFLLLFLLLFLLLFPLLLHFLLLLLVFLLFYLMPFSFILSTSLFISFFSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E1V7</accession>
    <name>A0A812E1V7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_66423</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004787">
        <property type="protein sequence ID" value="CAE1315424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E1V7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1315424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="165" mass="18955" checksum="30A03CF32C022F7E" modified="2021-09-29" version="1">MPTFTTDTSQTSTVSNIINIFAMSLPSRFFSVISLSICLFISIYLSIYLSQKEIKNVCIFLSILSFPSPSFLILHQFLSLALFLSLAHLSFIYLFLSFSLCFCTPFSLCLSFQISLFHYLSIYLSQSSYYLPMYLSISVYLSIYLSLLMYLSIYLSIYLSIYLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E291</accession>
    <name>A0A812E291_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_65059</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004686">
        <property type="protein sequence ID" value="CAE1314077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E291"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="400"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="435"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="489"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="562"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="600"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="624"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="651"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="677"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="708"/>
            <end position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1314077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="756" mass="88002" checksum="7B13FC103CC51901" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E3M3</accession>
    <name>A0A812E3M3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_64041</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004609">
        <property type="protein sequence ID" value="CAE1312881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E3M3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1312881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="338" mass="38459" checksum="366A1CF11DCB655C" modified="2021-09-29" version="1">MIRSYLSVCVSVPVFSHLSSIYLSIYLSIYLSIYLCLSHSVIIYLSIYLSIYLSIYLSLSHSVTVLLSSIYLSIYLSIYLCLSHSVIYLSIYLSIYLSIYLSIYVSFCYLSISNTEDISTYFFIYRHHLLAPDPQQFFMFITTLKFSGFLSEIFVRWPLFFFLFFFLSFFLYFLLLSLVLPLLRLALLLLPLPLILALLFSSSCSSSCSSSPFFLLLPLLLPLLLPFVVLLLPFALLLPYAPLLRLSLLLLALLFLPLVLVLLLLTLFLSLVLLLLLALLPLLLLLTLSLLLFVLRSRPADRLNSLPSGGEEPEGIYAEGRILFQGGKPTLNPFIRVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E4U3</accession>
    <name>A0A812E4U3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_64726</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004663">
        <property type="protein sequence ID" value="CAE1313643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E4U3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="131"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1313643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="369" mass="42560" checksum="740E37876FB542BC" modified="2021-09-29" version="1">MFIYWSLAFLKVCFYLSIYLSIYLSICEFLRSEIYLILFDLFELVSSCFHFLFRTILCCLSLPFEQKTLIRLEFALSCRAEAQFKALQRKHFGRGTDALPPSSLSIYLSIYLSIYLSIYLSIYLDVQDVYLSIYLSLFISIYLSIYLSIYLSIYLSFFSTISSQRLFPFHSFYIPRYFLFNPIFTRAKKVINFPPCSILGRDRKDIRRHFGRDIQGSGDLSPSSDSSTSSYSQTAGHTSRLVDNLSPRRCCVPAESEFVQAVVLFLDIEAERLTTAGRLSLSLVPLQLSDGFPSVFMENIYSPRTKNTPFSRYSSRTIVHWSSNYFQEAEESNQASARPSRRVSSNTSDYLSIYLSIYLSIYVCVCALI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E7Y0</accession>
    <name>A0A812E7Y0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_68398</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004979">
        <property type="protein sequence ID" value="CAE1317851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E7Y0"/>
    <dbReference type="OrthoDB" id="6819399at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1317851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="154" mass="18304" checksum="E8583632DE70F0D0" modified="2021-09-29" version="1">MKSDPTNSTVFRFFCDWRLVSAPKYFLDERKSKKKTELSVCEYLSHKNYTIFITSSIIIFARSRFFTPTIHLSIYCSLFMSIYLSSVISSDLSIYLSIFCNLFRSIYLSIFCNLFRSIYLSIFCNLFRSIYLSIFCNLFRSIYLLILNQRRGNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E8W1</accession>
    <name>A0A812E8W1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_70630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005169">
        <property type="protein sequence ID" value="CAE1320341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E8W1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="293"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="353"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="414"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="442"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1320341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="490" mass="57495" checksum="4A868F1A101EED5C" modified="2021-09-29" version="1">MLSTWLPCDRVERDLQRFTYPSIYLSIYLSIYLSIYLNSFNIKLSVCAFLSFFFLSLKLNFYLFCSPSVYFYLLFFMSGYLFCSHSFIYLSIYLSIYLTLFIIHPSIYPSIYLSIIITVCSYPSIHPSIYLSIHLSQSVHYPSIHPSIYLSISIYHSLFIFIHPSIHLSIYLSIYLSSSIYPSIHPTSFYLSIYLSIYPSIHLTCSLSIHPSIYLSIHPSIHPSIYHHSLFISIYLSIYLSIYLSIHLIYPTLFIIYLFISIYLSIYLSSVCSYLSLSIYLSIHLSFYPSHLFIIYPSIHLSIYLSIYPSHSVHYLSIYPSIYLSIYSLFISIYLSIYLIYLSIYLSHISSSIYLSIYLSIYLSQSVHIYPSIYLSPSYLSIYPTSVHYLSIYLSIYLSIYLSHHIHLSIYLSIYLSIYHSLFIYLSIYLSIYLSIYLSHSVHIYLSIYLSIYLSIYLSITVCSYLSLIPEIRYLSIYLSIYLSIYLSIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EBM9</accession>
    <name>A0A812EBM9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_69397</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005072">
        <property type="protein sequence ID" value="CAE1318894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EBM9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1318894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="246" mass="29182" checksum="8E6273A33A6DB674" modified="2021-09-29" version="1">MLISISVFIYLSIYLSIYLSIYLSICSYLSICSYLSIFLFMCKFVSIYLSIYLSIYLSIYLSLFVSIYLNLFVSIYLSIYLSKLFFIWIIFYSLLNSLANIYLSIYLSIYLSIYLSICEYVCLSIYLYLCLCVSVSYLSINLCLCEYLCLSIYLSIYLSIYLCLCEYVCMSVYLLCFNTIYLSIYLSIYIYIYLSIYLCIYIHLSIYTYISISIYLCIYIYIYLSIYLSIYLCLCEYLCMSVYLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ECM8</accession>
    <name>A0A812ECM8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_72643</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005336">
        <property type="protein sequence ID" value="CAE1322718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ECM8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1322718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="358" mass="41438" checksum="DC16E8DBCA21B7EC" modified="2021-09-29" version="1">MCFLFSSQRKHNAQIYVSKNTTVRSPFSLVFVSFLVHLSHSYHHFFPYSLFCLLSNKLISVFLSSKVIIYYLTLLISVYQYLFISVLLYSSIYLSIYLSIYLSIYLSIFVHICVYQFISIYICSYLFISVHIYLSIYLSIYLSVCLFPIYLSIYLYLFISVYISSYLSIFVHICLYLFISIYLSIYLSIYLSIYLSIYLYLFVSVCSYLSIYLSIYLSIYLSIYLSIYLYQFISIYLSIYLSIYLSISVHIYLSIYLSIYLSIYISSYLSIYLSIYLSIYLSISISVHIYLSIYLSIYLSIAYSNFPQAPKALPPRLKANKSTSSTSVSVTKVGPSSPLLSSDTTITATNGGVFPLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EDQ2</accession>
    <name>A0A812EDQ2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_71739</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005255">
        <property type="protein sequence ID" value="CAE1321662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EDQ2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1321662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="392" mass="46028" checksum="64030B2B41E7B6FF" modified="2021-09-29" version="1">MSTYATLTFYRLKSTSRSLLCVIYDLSIYLSIYLSIYLSIYLSMLVCLYLSIYLSIYLSQSVYLSIYLSIYLSIYLSIYLSVCFLLSIYLSISVCLLLSIYLSIYLSIYLSIYLSIYHPMASLRAQVVVIDYLLKLMVAPALVQQQMSYVKASLSFSVTFAHFSRHSSRVLLSFLFLFSVTFHFLLLFSFLACLKLLLFPSLKCTFLSFFFFFFRSFFFFFSFFLSVYSFVYDLFFYFLFNPSFFLSFFLSCFFLSFFLSFLFLSFFLVFQCYSHAKFFHQFLNLFFSLPLNHTSFFLTNTFVFPSILSYSIPSSFIVCYAFASLPKQNQTLSKIFPAATKTILFFSLSVRLPSFILLLRLLPSPLTTFPIIPHRTQSFFSFRFLRSFITSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EF04</accession>
    <name>A0A812EF04_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_71328</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005219">
        <property type="protein sequence ID" value="CAE1321217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EF04"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="305"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="395"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="439"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="492"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="517"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1321217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="546" mass="65550" checksum="A22225BDB575345F" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EGG6</accession>
    <name>A0A812EGG6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_73921</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005400">
        <property type="protein sequence ID" value="CAE1324193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EGG6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1324193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="257" mass="30123" checksum="D9AA1B2BBBD3500C" modified="2021-09-29" version="1">MRQDDSTVSIYMPNYSNLSIYVHIYRSISFCSYHLSIYLSIYLSIYLSIYLSILILFISIDLSIPFCSYLSIYLSIYLCSYIYIDLTFSILFISIYLSIYLSIYLCNSVHIYRSIYHILFIIYLSIYLSIYLSIYLSIYLSRSVHIYLSIYLSIYLSIYLSIYVSIPICSYLAAYHILFISIYLSIYLSIYLSIYLSKSVHIYLSITFYSYLSIYLSIYLSIYLSISSHHLPLFSAPVTSCYEDPFACFPAILNAPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EIX8</accession>
    <name>A0A812EIX8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_75310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005455">
        <property type="protein sequence ID" value="CAE1325695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EIX8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1325695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="173" mass="18436" checksum="DB4B000F47311EDF" modified="2021-09-29" version="1">MVSRDPGQACALRWQIHGHWGPCPVLRSSVADPWSLGTLPRPALFGRSSMVSRDLIHACSRQTRIHGLSGPCPGLPSSVADPWSLGTLPRPGLFGRSSMVSQGPYPGLRSSGAYPWSLGSLPRPALFGGRSMVSRDPAQACVLRSQIHSLSGPCPGLRSSVTDPWSLGTDRCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EJ57</accession>
    <name>A0A812EJ57_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_73370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005375">
        <property type="protein sequence ID" value="CAE1323479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EJ57"/>
    <dbReference type="OrthoDB" id="6282070at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134:SF22">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134">
        <property type="entry name" value="OS08G0543275 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1323479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="241" mass="28249" checksum="D45A5D7A92D685FC" modified="2021-09-29" version="1">MISIYVRQYIFQPIIAFSIYLSIYLSIYLSIYLLSHYVCMHVCMYVSISMRVRYLSIYLSIYLLAHYVCIYVCMYIYAGSLSIYLFIYLSAGLCMYVCMYVCIYLSIYLCRFIIYLSIYLSIYLSTYLSICELDDAIGYRFSLQLQFTRNHFFSSTTTSCEFTAHGFFSLLATIESFSIPRGTTSFVLTDINRVFNVSSNVPVGKVRKTKNSIEIRKKVSIYLSIYLSIYLSIYLRRFISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EKF3</accession>
    <name>A0A812EKF3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_74109</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005407">
        <property type="protein sequence ID" value="CAE1324329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EKF3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="388"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="432"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="474"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="523"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="569"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1324329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="699" mass="80406" checksum="BC27B478D098C192" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EKX5</accession>
    <name>A0A812EKX5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LZTR1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SPHA_74350</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005420">
        <property type="protein sequence ID" value="CAE1324629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EKX5"/>
    <dbReference type="OrthoDB" id="10250130at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18505">
        <property type="entry name" value="BACK1_LZTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18506">
        <property type="entry name" value="BACK2_LZTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18308">
        <property type="entry name" value="BTB1_POZ_LZTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18309">
        <property type="entry name" value="BTB2_POZ_LZTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000024">
        <property type="entry name" value="Leucine-zipper-like transcriptional regulator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051568">
        <property type="entry name" value="LZTR1/Attractin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46376">
        <property type="entry name" value="LEUCINE-ZIPPER-LIKE TRANSCRIPTIONAL REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46376:SF1">
        <property type="entry name" value="LEUCINE-ZIPPER-LIKE TRANSCRIPTIONAL REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="30"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="265"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAE1324629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="479" mass="55100" checksum="946F8F746B00C9D8" modified="2021-09-29" version="1">MFSILYKFSSYPKCTLHEDYGRLLESRQFCDITFIVGEEKVEIPAHIALVAARSPLLRAKIRRAKAQLAQEVAANDAANCQNEDIQQQSSSSHQKDSSSRLKVIIPDAVPKAFEMVLSYIYTDRIHPTQKGQEPSSNEVILLMMDVYRLSVQFNMTRLEQLCINYLEACIGHKNVLVALQNTAKLKLDFIKEYCLKFIVKESNYSQIIMSKEFETIDQPLMVEIIRRKHQPQFRTLPDPHPDPNNSNTLEKDMETFLKVVGHEFCDITLMLDGAPIPAHKSILAARSSYFEAMFRSFMPEDNTVKIAIGEMVPSQQAFHSLMRYIYYGDVTMPPEDSLYLFSAPYFYGFTNNRLQAFCKHNLEMNVSFKNVVQILEAADKIQASDMKKHALNIIVHHFPKVARLPQIRSLTRELLLDIIEALANDMNEARLFPVLGCIHPQLNTHYQNYQQHIQIFITLSLTIEIDISPINMCHVVTYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ELV6</accession>
    <name>A0A812ELV6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_73643</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005382">
        <property type="protein sequence ID" value="CAE1323793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ELV6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="285"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="331"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1323793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="355" mass="41676" checksum="6398B503ECA205B1" modified="2021-09-29" version="1">MNFKFLLDFSKLFHCSVRSLLPFSFFSSLILHFSFALISFSLSLSLSLFLSLSLFLSLSLSLSLSLSLSFSLSLSFFSLSSLSFSLSLSLFSLSFSLSLSLSLSFSLFLSLSFFFSFSLFSFIFFFLSFFFYSRLSFTDIYLSIYLSIYLSIYLSPIYIYFNIFISIYLSIYLSIYLFVAYSHVFQYIHIYLSIYLSIYLSIYLSICLSYIHIYLSIYLSIYLSISLSPIHVYFSIFISIYLSIYLSICFCLLPIHIYNFTIFVSIYLSVCLSPIYIYFTNLSIYLSIYLSIYLSIYSYLSLFISIYLSIYLSIYLSPIHNYFYFYKNVKLSIYLSIYLSIYLSLSLSIYIYIYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ENL4</accession>
    <name>A0A812ENL4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_74173</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005408">
        <property type="protein sequence ID" value="CAE1324378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ENL4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="296"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="436"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="463"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="515"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="542"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="580"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="605"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="635"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="663"/>
            <end position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1324378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="684" mass="81970" checksum="89A0B8A060E9A37E" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EPC8</accession>
    <name>A0A812EPC8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_77425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005517">
        <property type="protein sequence ID" value="CAE1327956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EPC8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="322"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="408"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="449"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1327956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="611" mass="71639" checksum="EBBC19FD5E0C4A6D" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ETM9</accession>
    <name>A0A812ETM9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_80725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005609">
        <property type="protein sequence ID" value="CAE1331551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ETM9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="274"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1331551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="316" mass="39490" checksum="F4E002277ACFFEE5" modified="2021-09-29" version="1">MRSFFLSFSFCNSFFFSFFLSFSFCHSFFFLSFFLFFFFLNFFFSFFLSFSFCNSFFFLSFFLSFSFCNSFFFLSFFLSFSFCHSFFLSFFFILSFFLFFFFSFFLSFSFCHSFFLSFFSFFSFFSFFLSFFSFCNSFFFLSFFLFFILSFFLFFSFSFFLFFFFLFLFFHSVILSFLFFFLFFSFCNSFLFFFLFSFSFCHSFLSFFFFFFFLFLSFFFSLICFFFFFFFFFSFFFSFCNSFSFSFFLSFFSFCHSFFFFLSFFLFHSVILSFFLSFSFCHSFFLSFFFILSFFLFFFLTQPFCPSFTLSLSLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EUD9</accession>
    <name>A0A812EUD9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">VEP1</fullName>
            <ecNumber evidence="1">1.3.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_79449</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.3" evidence="1"/>
    <dbReference type="EMBL" id="CAHIKZ030005568">
        <property type="protein sequence ID" value="CAE1330102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EUD9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047787">
        <property type="term" value="F:Delta4-3-oxosteroid 5beta-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1330102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="354" mass="38326" checksum="EE4C021241B589D1" modified="2021-09-29" version="1">MLKESRSTYLLYENTLSITPLFLQLPFSSLSSLSPTNLIDKSKEPGFLGFRARSSLQNFIYKKARTPSPHSLSPLSPLPFSSPPFLLSPPFLPLPSLSLLSCSLPPAIALSLPAIALSLLPSCLSPAIASLLSCHRSLSPSLPSLSSLLPSLSLYTIRHLSLHFRHRSLSLSTLLPSLSLSLYSSAIALSLTTLPSLSLSLLFCHRSLSLSTLLPSLSLSLYSSAIALSLSFSITHTVSHLLTHYLSASQYLSIILYHSRSLSFSLSLFVFLTLTLCLSHSVSLSLSLCVSITLTLCLYHSHSVSLSLSLCVSLSISPSLSYNSLYHSHPFPLSPLSNSFSHFLTHARGRSLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EUF9</accession>
    <name>A0A812EUF9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_77918</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005525">
        <property type="protein sequence ID" value="CAE1328316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EUF9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1328316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="287" mass="33658" checksum="9EF6DC293CE1B146" modified="2021-09-29" version="1">MPLTLSHSISILPPQIVYTSYPFSLSLSLSLSHIYLYIYLSITFPSNLHIPLRLSASLSLSLSLYCVHYLPMHLNLSLSNYLSIYISQSVHYLSIYLSIYLSMYLYSYLIMFIVYLSIYPFLFIYNYVYSISIYLSIYLIIFIVYLSIYLSIYLSIYLRLFYLFLFISNYVYSTSIYLSIYLFNIFLMISRSSRNQHTLFILPRTDGYINRVEYRRSSIHKSHMDIITHNVSLYPSMHPLSLFHLSPSHSVSLSLSLSFCARVRGGYAQCAYISKWTESFVRSLLAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EVR7</accession>
    <name>A0A812EVR7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_80723</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005609">
        <property type="protein sequence ID" value="CAE1331573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EVR7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1331573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="302" mass="36050" checksum="1FE9093262F65FCD" modified="2021-09-29" version="1">MIRDFRYSFCLGVFLGFFFSFSFFFLFFFFLFIFLFFSLFVFSFLSFFFIFPIFLLFFFSFLLFFLFSFLLFFFSFVISFFIFFFFSFLFFFSFVSFFFIFPIFLLFSFLFVFSFSSFFFSFFISFFFFSYFLFSVIFHFFFFFLLFLFFTSGHISISPYFPDTPCETYPPLFSEQFNIPGMWLAPAWAHQIQAQVYLDTNTCKRSPPPLPSLLNRHSPISFAFPFYYGPLLSLMRPPRSLSHSSPVTPPPHTHSTIPLPYAVVRSHDLVAGRARTLDERDQSEGATSSEDTSRRGKEMTSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AML2</accession>
    <name>A0A812AML2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_1769</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000050">
        <property type="protein sequence ID" value="CAE1146157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AML2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1146157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="337" mass="39640" checksum="E5F00FF678DEB5B5" modified="2021-09-29" version="1">MYLTISTFLSPLHCLYSSIFIPPRLSTLFSSLLSPPPFFPVLFLLLPSFQSSFSFSLFSFLFLLLPFFPCLFPPPPFYPIRFLLLPFITSFFFSLFSPSAFFFSLFLFSFFFSLFLFSFFFSLFLFSFFFSLFLFSFFFSLFSSSFFSLFSPSSFFFSLFSSSFSFSLFPSSFSFSLFPSSFFFSLCLALLALLILFLAFHSSLSLFANPFSSCLLSSSLSLLYLPFFFIPFYLLYFPHFFTSCSFPTLSLYMPFFFLHIYSFSFYPNLFFCFISSLHFPSTFFCFLCFFSLSFSLSLHLYHIFSFFQFSLYLPSPTSFLLIFLPHLLLVCFFSYFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AP38</accession>
    <name>A0A812AP38_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_2588</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000072">
        <property type="protein sequence ID" value="CAE1148978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AP38"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="387"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="428"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="458"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="486"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="520"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="546"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1148978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="569" mass="68875" checksum="F5AAFE624EEC39B5" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812APK7</accession>
    <name>A0A812APK7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_3118</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000091">
        <property type="protein sequence ID" value="CAE1151353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812APK7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032582385" evidence="2">
        <location>
            <begin position="25"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="301"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="336"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="409"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="504"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="633"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="661"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1151353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="685" mass="74598" checksum="0958FB45E3BB94AB" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ASS8</accession>
    <name>A0A812ASS8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AK3</fullName>
            <ecNumber evidence="7">2.7.4.10</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SPHA_4020</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Farmed</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the adenylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.10" evidence="7"/>
    <dbReference type="EMBL" id="CAHIKZ030000123">
        <property type="protein sequence ID" value="CAE1153722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ASS8"/>
    <dbReference type="OrthoDB" id="439792at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046899">
        <property type="term" value="F:nucleoside triphosphate adenylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000106">
        <property type="entry name" value="Adenylate kinase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006259">
        <property type="entry name" value="Adenyl_kin_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007862">
        <property type="entry name" value="Adenylate_kinase_lid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036193">
        <property type="entry name" value="ADK_active_lid_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01351">
        <property type="entry name" value="adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05191">
        <property type="entry name" value="ADK_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57774">
        <property type="entry name" value="Microbial and mitochondrial ADK, insert 'zinc finger' domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Adenylate kinase active site lid" evidence="6">
        <location>
            <begin position="88"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAE1153722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="185" mass="21373" checksum="BB26F061BB803083" modified="2021-09-29" version="1">MLRAQILQKTEAGLATKKYIDKGELVPDDIMVNLILNEIHSLGHVSWLLDGFPRTVPQAISFHKVEPVNIVINLNIPFDVIIDRIKGRWLHLPSGRVYHTEFNPPKTPGIDDVTGEPLIQRDDDKPETVRQRLETYKRQTEPVLEYYKNSGLLREFKGKYTNEIWPKVRELLSTQMTPIASVDYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AVY1</accession>
    <name>A0A812AVY1_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">VWFD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SPHA_7898</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000256">
        <property type="protein sequence ID" value="CAE1164067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AVY1"/>
    <dbReference type="OrthoDB" id="6059693at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19941">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050780">
        <property type="entry name" value="Mucin_vWF_Thrombospondin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024731">
        <property type="entry name" value="NELL2-like_EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036084">
        <property type="entry name" value="Ser_inhib-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002919">
        <property type="entry name" value="TIL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014853">
        <property type="entry name" value="VWF/SSPO/ZAN-like_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11339">
        <property type="entry name" value="EXTRACELLULAR MATRIX GLYCOPROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11339:SF413">
        <property type="entry name" value="TECTORIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12947">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01826">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00094">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00832">
        <property type="entry name" value="C8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00216">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57567">
        <property type="entry name" value="Serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="743"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="772"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="798"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="5">
        <location>
            <begin position="52"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="5">
        <location>
            <begin position="525"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAE1164067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="827" mass="91938" checksum="C81EF9F323053B5A" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AWR7</accession>
    <name>A0A812AWR7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_6510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000213">
        <property type="protein sequence ID" value="CAE1160636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AWR7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1160636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="333" mass="39479" checksum="FA71FE9FBABEFE4D" modified="2021-09-29" version="1">MFFIFFLFSSFVIFCFFVSFLNFVVFSSSFFSFPEKKKKVKNFFLRFFFFSSLFDFAFSLFSSFLFVFLFVFYAFFFFFFFSDFSFRFPSLFSFFVVRLLSFLILNIWIVLFIFSFFSSFLCFLFSLDFLVHFLSVRFFFFFYSSFFFLFVFIYFYLFCSFFFIFFLFFVFIRFSFLCSFLSLFFLSFSSSLFPSLCISLFISIHLFPSLSLLLFPLSTTLYHFFSLLSPPPSLPLFSPFSLPLSLPSLSISLRLILSHFLSLLPSIFPPFSTTLYPSLTPLFPSPLSPPLSLPPLFLSLLSPSPFSLSPFHLLSFRGDERERSSIVSQCHLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AXS2</accession>
    <name>A0A812AXS2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_6263</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000206">
        <property type="protein sequence ID" value="CAE1160129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AXS2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1160129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="295" mass="33247" checksum="0227CEB78BEF32DB" modified="2021-09-29" version="1">MKADRLLHEYKPGIFSLVFFFYSFLDIFILSLYLFLFFSLSLSLFLFLSPLSFLSPHSLSLNLSLSLSLSLFLSLSLFLFLSLSLFLSLPLSLSLNLSLFLSLSLFLFLSLSLSFSLSHSLSLNLSLFLSLALSFSLSLSLFLSLSHSLSLSLSLTISLSLSQFFNIFLFLSFLFNSVLFLSSTTIFSIFFSFLPPSLSISLSLSLSLSLSLSLLFSLSRFPFSPAFFFKKTMHEKANFNEQINEPFIFIHLFFFTSLFHHHPGFLSLSLSLSLSLSLSLSSLSLLSLLSSFFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AZI2</accession>
    <name>A0A812AZI2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_7585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000242">
        <property type="protein sequence ID" value="CAE1163125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AZI2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1163125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="160" mass="19153" checksum="187E5EDDBFAA9F82" modified="2021-09-29" version="1">MRDFFFFFFFFFFFVSFFFFFFFFSSSPSPFFFSSSSSFFFSSSSSFFFFVSSFFSSSFSPFFFFFFFFRKFTIMALHHIRNIRLLSRLDNNEAVQFIFHRNGQPTPVPPHQPTPESLKSHISLWISCFDSLSLNTLTTTHIFFLNTFFVPRLSPSHTTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B008</accession>
    <name>A0A812B008_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_8573</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000279">
        <property type="protein sequence ID" value="CAE1165760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B008"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <begin position="12"/>
            <end position="32"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="65"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="110"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="133"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
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            <end position="240"/>
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        <location>
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            <end position="271"/>
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            <end position="431"/>
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        <location>
            <begin position="438"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="462"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="493"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="529"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1165760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="553" mass="68311" checksum="25575BE11A1DFB4D" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B0K0</accession>
    <name>A0A812B0K0_ACAPH</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
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                <person name="Bekaert M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
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    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000262">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1164616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="360" mass="40319" checksum="CBF0549FBD03F9B6" modified="2021-09-29" version="1">MRTRQLHLWISASRDKCVPDNCISGYLHPETTAYQTIASLDICIVCVQQCASWISADKCVPDNCISGYLHPETNAYQTIASLDICIPEQMRIQTNACRISASLDKCVPTIASLISASRDNYVPDNCISGYLHPETNAYQTFASLDICIPRQMHYQTIASLISASQNKCVPDNCMHPRTNICIPISASRDKCVPDNCISGYLHPETNAYNNFCVSAPRQLHLNCISGYIPRQMRTDNLRISTAYQTIASLDICIPRQLHAYQTIASLDICIPRQLRTRQLHLWISASRDNCVPDNCISGYLHGHLTIASLDIPHSNLYETTAYPDNCISGYLHPANSYNCINLRTRQLHLWISASRDKCCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B3R2</accession>
    <name>A0A812B3R2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_9275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000297">
        <property type="protein sequence ID" value="CAE1167227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B3R2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
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            <begin position="12"/>
            <end position="32"/>
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        <location>
            <begin position="53"/>
            <end position="73"/>
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        <location>
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            <end position="142"/>
        </location>
    </feature>
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        <location>
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        </location>
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    </feature>
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        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1167227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="260" mass="30609" checksum="2B2423514BB906EB" modified="2021-09-29" version="1">MQTPPSGNTLKYLSIYLSIYLSIYLSIYMGSYDSFKLAVHKSLCIHLITCWKVSIYLSIYLSIYLSIYLYIYLSIYLSQSVHIYLSMYLCIYLSIYLSMFLVYLLCLFKSIYVGLFKSIYLSIYLSIYLSIYLCSLSVQIYLSIYLSIYLSIYLSIYLSYCHLLLFLYVTFLLFSFHVSPYTFCSFSFLYFYSHISLGLFYFQLSLSLSLSLSLSLYLSIYLSISFISDHISIYSYLSIYLSIYLSIRVCSFLSLILFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B4G1</accession>
    <name>A0A812B4G1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
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                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000424">
        <property type="protein sequence ID" value="CAE1173567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B4G1"/>
    <dbReference type="OrthoDB" id="6218771at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1173567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="913" mass="103538" checksum="A95F553893920370" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B6R5</accession>
    <name>A0A812B6R5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_11960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000400">
        <property type="protein sequence ID" value="CAE1172180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B6R5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="346"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1172180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="370" mass="44251" checksum="182810E169C289B2" modified="2021-09-29" version="1">MSVSLHLVTVLLASVFLFLNRFFLSFFFFFHSFFLSFFLSFFLFLIFNPSVFLFIFLTRFFLFSFLSFFLSFFLSFFLSSNTQCCLSSYFSTVSFFFSFFLSFFSFFFFLLIFNPSVFFFIFLTRFFFSFFLSFFLSSNTQCCVCLLISQPFLSFFFLSLSVCLPFLLLTRFFLSFFLSFFLSFFLSSNTQCCVCLLISQPFLSFFLSFFLSFFLSFFLLIFNPSVFFSYFSPVSFFISFFLSFFLLILSASVFLFLNRFFLSFFLSFFLSFFLLIFNPSVFFSYFSPVSFFLSFFLSSNTQCVCLLISQPFLSFFLSFSVRLSSFLTSHPFLSFFSFFLRLHFSYISFFLFFHLFSFNIFLFFSPLISQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B767</accession>
    <name>A0A812B767_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_11094</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000365">
        <property type="protein sequence ID" value="CAE1170433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B767"/>
    <dbReference type="OrthoDB" id="6260718at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1170433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="178" mass="20890" checksum="0050B290E4A2D0A6" modified="2021-09-29" version="1">MSENTPLDQLADAADRIFSQLDHQTTPVLSAETSSDHRSLEKAVEELQRQVRDLTFSLKNRGRNRFPPRRRLRSRRVRATNLADLSIYISESVRIYLSIYGFQYLFISIYLSIYLSIYLNLFISIYLSIYLNLFISESVHIYLSIYLSIYLSKGFVHIYLSIYLSIYLSIYLSLFISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BF32</accession>
    <name>A0A812BF32_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="13">GRIA2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SPHA_18844</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000680">
        <property type="protein sequence ID" value="CAE1233134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BF32"/>
    <dbReference type="OrthoDB" id="5984008at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000087">
        <property type="entry name" value="glutamate receptor 4 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015683">
        <property type="entry name" value="Ionotropic_Glu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18966">
        <property type="entry name" value="IONOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="12">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAE1233134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="264" mass="30227" checksum="63E4D6E14A47C629" modified="2021-09-29" version="1">MSSNPSVFVKSIREGVERVRNSKGKYAFLLESSSNIYLNNRKPCDTMMVGGTLDSKGFGIATPKGSAIRDTVTLAVLELKEEGSLHKLYQKWWYEKGQCGFDSGNDSKKRSLSLSNVAGVFYILICGLALAIALGIVEFVCKLKCRGSKGEYIPGRKSGDASSGDKDGTGHLCPDYLPEKAVSTFLYFFFFVLYFLYFLFSFFSFFIFSLFLSYFLFFLFFRFFLLFSLFSLSFLSLFSFYLLSFLYCFFLFFLTYFSFFILLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BGF9</accession>
    <name>A0A812BGF9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_18079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000648">
        <property type="protein sequence ID" value="CAE1231383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BGF9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1231383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="210" mass="25206" checksum="EF08852B94792594" modified="2021-09-29" version="1">MAFNSSFLILFLIPFILSCVLPFLFYFISLFHLILLLSFSFLSSFPFSSVFFLSFFVLFLSFFFLKLFFSFFHFFLSLLILFLPSAFFLYSLFSFPFFICSFSFLFDSSFCFPSLSSHSFFIFLYFFIFSLNCSFFHFFLSSYVILFSFSIFFLFSSLLFHSSFLLPSLFSPFFISSFFFFLLSFFLYLFLSLLIRFLPYSLISFLFFLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BHM4</accession>
    <name>A0A812BHM4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_17738</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000634">
        <property type="protein sequence ID" value="CAE1230437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BHM4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1230437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="349" mass="42871" checksum="694E1BF01467799C" modified="2021-09-29" version="1">MRRDDVSDKAKLLSFFFFFPSFCLSSFFLSFSFFNHSLSFSFFLSFFLSFFLSFFLLLFFLSFFFLSFSLLSFLHFSFFLSYFHSFSSFLPFAFFLSFFLSFFLSYFLSFFLLFFLFSFFLSFFLSFFFPSFPLLFFLSFFLFLLSLSFFLSFFFLPFFLTFYLFSFIFFVLLTLFRPFLSFFLFFLPSSILFSHLFLSFFSSYLPLPLPTFFSISFFFLFLLSFFLPSLPLLFFLFLSFFFFVPSIFFQSFFLSVSTYFNFPFLSFFFSFFRYFFLFLSSVFSFTFLPFFFFVPSIFFHSFFFFHSLHILIFFLLFSLSYFPLYFLLIIFLFSLFFFFFFLFPPSFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BKD7</accession>
    <name>A0A812BKD7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_19310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000700">
        <property type="protein sequence ID" value="CAE1234184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BKD7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1234184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="344" mass="40803" checksum="E3395FDCE23A915E" modified="2021-09-29" version="1">MMSTKSFRQYKVHCVRTESIYHLSFILCYNSFFYLSIYLSIYLSIYLSIYLIFYLSISFFASSILSIYLSIYLSNSLFLSIYLSIYIIFYLSHSFFYLSIYLSHLFSIYLSIYSSISSIYLSISFNLSHSFIYLILFYLSSIYLSIILFISFSSVSIYLSSIYLSIYLYLIYLSIIIYLSIIFFYLSIIYLSIYLSIHSLQYLSILSIYLILFYLSHSFSIYLSIYLSIYLSHSLQYLSIYLSIYSFIYLSIYLSIYLSMYISVILSSIYLILFHSSIYLSIYLCVCVILLCLSIYQSISFFYLFILFSIHIYLSIYLSIYLSIYRLDIYLSIYLSISFSSVSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BP64</accession>
    <name>A0A812BP64_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_20270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000745">
        <property type="protein sequence ID" value="CAE1236521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BP64"/>
    <dbReference type="OrthoDB" id="6128227at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="83"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1236521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="365" mass="41943" checksum="95A3A7E78A1A51F9" modified="2021-09-29" version="1">MTKLIEKDGQIQVNYLNSENQKFDVSQCGKIVAPKSNPKEVIESCLAVLDLIKEKRAPDGVLLDRTKISCSRKGTYKNGEDYDVLDKILGKGLNGQIVVVRDKKLGSEHALKTVMLAYFDSNEIRCWTDLEGYNNFPSLYMFNKQNGQIEFHYEILDKAVTISDIIDNHMLKMRENHELLRHFSLYVLQGLLEASSVMHSKNWLHDDLHENNAMLQAKPSSELKVRVLDFGRAKKLDKKATITNDIHQIIRVFTSVYVTEKFQNATDLQKNWEVKLQEQAKELQLSKENKDELLNLIKIALDVHLTEQEIELKEMVDCKLKDSLVENPDIMKEICKLIFPDYSLETDNVDAGSSDFISFNIFKIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BR53</accession>
    <name>A0A812BR53_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_20645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000758">
        <property type="protein sequence ID" value="CAE1237233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BR53"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1237233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="215" mass="25137" checksum="DC89625CB3B0AD8A" modified="2021-09-29" version="1">MRFSETPYGYSISFSLSLSLSLSLSLSLSPLHIAPTLTHLQGRPTPARSLLSLHLMSESLRPFFFTVFPFFIIFYLFLSSYNKFFLLFLSPFILLSKSVSLSFFNHFLPKLFSSTFFFSYIIVFFFFLLLSLLFFLSFFLSSNPFLPGFSLYIIFIFPSFFLSFFLSFFLSFKHFPAGFFLYIILIFLSFSFFLSFFLSFFLSFFLSSASSPFFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BS05</accession>
    <name>A0A812BS05_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BAIAP3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SPHA_21696</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Recycling endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000799">
        <property type="protein sequence ID" value="CAE1239170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BS05"/>
    <dbReference type="OrthoDB" id="7976202at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099503">
        <property type="term" value="C:secretory vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010439">
        <property type="entry name" value="MUN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014770">
        <property type="entry name" value="Munc13_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014772">
        <property type="entry name" value="Munc13_dom-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052095">
        <property type="entry name" value="UNC-13_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45999">
        <property type="entry name" value="UNC-13-4A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45999:SF4">
        <property type="entry name" value="UNC-13-4A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06292">
        <property type="entry name" value="MUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51258">
        <property type="entry name" value="MHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51259">
        <property type="entry name" value="MHD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0967">Endosome</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MHD1" evidence="6">
        <location>
            <begin position="71"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="MHD2" evidence="7">
        <location>
            <begin position="315"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAE1239170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="375" mass="43661" checksum="1491F3574F123B87" modified="2021-09-29" version="1">MLMPSKGTSEWYERISKRVKSKSKNEGDIMRSLIELTTLLNADIHQAVHFYQKLYENIVGVEYVPLAYLHLEKLLAGDVITALKDEEFCKFKRFIPEMEQESLGITRYYEWFRFAVQKWLLTAQVKATARVTKAVEVDMVYSNISNAKYSSSAVDVCSLFHHMVDFWTNLEWPEACDAYSFTANLTQNICDNAVMYSELIHDKLYATGFYDEDRQFDLSDQLCITINNIEHVRVTLKPLAETMRFSILEEDLERVDPHKRASLEKVNLFSLTNKADIIMTNKIKKVLDHVADRMRPDIKKDVFHMNWAPDVVPADEAIVDLMEYLDKNLVTLNQNLVSANFNRILDSIWVEVLKEFQDVMITEDMVSERLSYSNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BUV9</accession>
    <name>A0A812BUV9_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerases I and III subunit RPAC1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SPHA_24074</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000893">
        <property type="protein sequence ID" value="CAE1243935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BUV9"/>
    <dbReference type="OrthoDB" id="270173at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07032">
        <property type="entry name" value="RNAP_I_II_AC40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.120.12:FF:000003">
        <property type="entry name" value="Dna-directed rna polymerases i and iii subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="entry name" value="DNA-directed RNA polymerase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033901">
        <property type="entry name" value="RNAPI/III_AC40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050518">
        <property type="entry name" value="Rpo3/RPB3_RNA_Pol_subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800:SF13">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="Insert subdomain of RNA polymerase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RpoA/D/Rpb3-type" evidence="7">
        <location>
            <begin position="1"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAE1243935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="254" mass="28634" checksum="A5F269371B5DF7EF" modified="2021-09-29" version="1">MAIEKVYVNNNTSIIQDEVLAHRLGLIPIFADPRLFEYVSEGDEEGTPSDTIVFDLKVKCTKNPTADTTDPDDLYKNHKIYSRHLKWIPIGNQSDLFKEGDIRPVDDDILIAKLRPGQELDLRMHCVKGIGKDHIKFSPVATASYRLLPEITLLAPVQGVKAEKLQKCFSPDVIEIDIVDGVKTARVAHPRKDTCSREVLRHDDLKDLVRLSKIRDHFIFSIESTGALAANILFSEAVKILMNKCQSFLSKIKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BW80</accession>
    <name>A0A812BW80_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Zinc finger Ran-binding domain-containing protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SPHA_28065</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001105">
        <property type="protein sequence ID" value="CAE1252645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BW80"/>
    <dbReference type="OrthoDB" id="1878647at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001530">
        <property type="term" value="F:lipopolysaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1060.10:FF:000004">
        <property type="entry name" value="Zinc finger Ran-binding domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.10">
        <property type="entry name" value="Zinc finger, RanBP2-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12999:SF17">
        <property type="entry name" value="ZINC FINGER RAN-BINDING DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12999">
        <property type="entry name" value="ZINC FINGER RAN-BINDING DOMAIN-CONTAINING PROTEIN 2 ZRANB2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00641">
        <property type="entry name" value="Zn_ribbon_RanBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RanBP2-type" evidence="10">
        <location>
            <begin position="78"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="159"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="278"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="185"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="212"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAE1252645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="386" mass="43405" checksum="34777AEBFEF22998" modified="2021-09-29" version="1">MEGVITEVSSSLFIYKFSSFYTVPLEILFKPIKNSKYLSWLAQRKTFNMAEKKDGVTYKKGGTEIGKAMAEKSRGLFSADDWQCKSCGNVNWARRTACNMCNAPKYGRIEPRTGYGGGYMERDEVVEYIERNESDDEYDEFGRKKKKYRKVDAADKIKSQSPVIKAAEEEEEDEDADISKYKLESEEEEDDDDDEEGDLSKYNLVESDEENDKLKNRKSDSRTTVQALLQVLAVGRTVGLEVILEVLLLQVDHHVHTPASPDLIPVLDHRQYPAQHLPDTDHQLGGRGGEPAPAPGPGPAHQKGRTLEKDDVPGLGRLHVQGHVQDPKAENLDPTGRGAETWIVGGQKQSNFPLERFAKNQQKRNKFFFFSLSLSLSLSLSLSLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BY10</accession>
    <name>A0A812BY10_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_25643</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000970">
        <property type="protein sequence ID" value="CAE1247407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BY10"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1247407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="218" mass="24302" checksum="7FD60A785268ADF3" modified="2021-09-29" version="1">MFLFSFLSLSKRLFPFFLFLSPPPPPLSLSLSLSLSLYLSIYLSITFSCWLDFIISFLLLTNFSFVVLFLLPLFISLYRSFPFFFLTSSIHFVLSRYSASLSLSLSLSLSLSLSPISLSPSLSPSLSLSTSLSSLSLSPSLSLHLFLSLSLSFFFIFFLAYLCKMSLLFDPVSVTCATYNSLLYPNRDEGCSSVNASPLSLGPSRFLLPKKNCSSHKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BYK4</accession>
    <name>A0A812BYK4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_24089</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000894">
        <property type="protein sequence ID" value="CAE1243989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BYK4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1243989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="199" mass="21564" checksum="C03D59A359DD1F84" modified="2021-09-29" version="1">MIAVLRSAYPLSVTDTTIIVNHFVGKNYFPKLSLSLSFSFSLSLSLSLSLNLSLNLSIYLSLSLSLSLSFSLSLSLSQSHLSIYLSISFLSLSRSLSRSLSLSLSQSLYLSIYLSLFLSLSRSLSLALFLSRSLSLSLSFSLSRSLSLSLSISLSIYLSISHTHTQARCGESLTILSLLLCNVLEQTTSLASARSILQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BZ62</accession>
    <name>A0A812BZ62_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_24380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000908">
        <property type="protein sequence ID" value="CAE1244611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BZ62"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="273"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="304"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1244611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="327" mass="37529" checksum="D3D5662B94D0C04B" modified="2021-09-29" version="1">MLTSLFNVIQDKNVDYFSFFFFSLEIHKFVEISCLFSSFPSDNTLIYLFLSLLIPFSGTSFLLLQPLLLFIFSFSYTILPNTATPFYLSIPPLFLDAIFLSFATNTLFFLTHLLAAFPNIHLQHLLSLLLPISLFTATSFSLVSLTFTRFVYSIHFYPSAIQSTKLDGFLSLSPSFPPQSFVYFSLESFSIYISSCSHVPTSVLSYLSTSFDSYLSIYLSIYLSIYLSIYLSISTGPDLSIYLSIYLSIYLSIYLSIYLNWSRSIYLSIYLSIYLSIYLSIYLSICSYVPTSVLSYLFASFDSYLSIYLSIYLSIYLSIYLSDHNWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BZ83</accession>
    <name>A0A812BZ83_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Purple acid phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SPHA_28298</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Farmed</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="3"/>
    <dbReference type="EMBL" id="CAHIKZ030001112">
        <property type="protein sequence ID" value="CAE1253089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BZ83"/>
    <dbReference type="OrthoDB" id="45007at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00839">
        <property type="entry name" value="MPP_PAPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.380">
        <property type="entry name" value="Purple acid phosphatase-like, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041792">
        <property type="entry name" value="MPP_PAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015914">
        <property type="entry name" value="PAPs_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008963">
        <property type="entry name" value="Purple_acid_Pase-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45867">
        <property type="entry name" value="PURPLE ACID PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45867:SF10">
        <property type="entry name" value="PURPLE ACID PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16656">
        <property type="entry name" value="Pur_ac_phosph_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49363">
        <property type="entry name" value="Purple acid phosphatase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Purple acid phosphatase N-terminal" evidence="6">
        <location>
            <begin position="73"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="5">
        <location>
            <begin position="173"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="406"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAE1253089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="505" mass="56997" checksum="723371FAF29386B3" modified="2021-09-29" version="1">MSILSRRDFSCYRFSLSSFSSFGYRYPYHVLQVLLLLGATLDLSMSVPSVIIPVNKTGSVPPIPNRENCQLHGIHLAYGNTVHDMVIIWSTVVNCTSQVRYGKHPKILNNTVSSKVVYFNESNPLGRHYLYRAELNNLTPDTLYYYYISNNYHVGITRYFNIPPNGTNWSPSFILFGDLGVQSHIHTVLTNEIRNGKYSAIFHVGDFGYDLESDGGTVGDSFMDIIEDYASYIAYMTAPGNHEINGGNFSHYRYRFSMPQTKWPMTVNKLWYSFDIGPIHFISYSTEAYFTNPQTDGAAQSAWLIKDLKEANLNRKKRPWIVAYGHRPMYCSNTDFDDCTKNNSVVREHLESIFYIGGVDIIFEAHEHSYERLYPVYDNKVMSYNYTNPLAPIHIITGAAGNKYNSDPMNGPKVNQTSTSSPSLNTTANQTSTPKTSVNISAKWTAFRQSEGSLNSYDPFLGRGVTSSICLATCLTSVFSILLSSKPFTISPFRPSLSIAFFSHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C0Q8</accession>
    <name>A0A812C0Q8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_25094</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000948">
        <property type="protein sequence ID" value="CAE1246309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C0Q8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1246309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="218" mass="25154" checksum="D8034AB6853B83F5" modified="2021-09-29" version="1">MAYKLKGTELFAFGLEIFLLYICTSSLFFTRLFSVVSPHFCSLRKCFLLTHVSFISTHNSPYLYICLSVYLSISMSLYLSIYLSQCVHIYLSICLSVCLSVYISISLCSYLSIYLSIYLSIYLSIYFNVFISIFLIVFISIYINVFISICLSIYLYQGVHMYLSICLSQCVHIYLFQYVSDHGTSWIPFFFLSTILSSYNLFLLCAVIVSISITIYLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C1R6</accession>
    <name>A0A812C1R6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_28052</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001104">
        <property type="protein sequence ID" value="CAE1252610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C1R6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1252610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="201" mass="22430" checksum="9514D034130D0E0D" modified="2021-09-29" version="1">MRWTHVDRGCAADVRFKEGGFLLRVYSRQYSGRSLYAFPSIFRLSLQPATLSWAERAWHSVRRQEWAVVVESATLVLAASSAFIASNAVLSKNVPSDLVVADDSRDFVVVFFKILLRFFKKNPFFKISSSSSSSSSSSSSSYSSSSSSSSFCPTSIQTLSFYLLLSYTFSQILALFLSHLFSMPPLNSLFLFLPLQTTTTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C1Y6</accession>
    <name>A0A812C1Y6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_26292</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001004">
        <property type="protein sequence ID" value="CAE1248771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C1Y6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1248771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="246" mass="29739" checksum="9B757402BEA8955C" modified="2021-09-29" version="1">MFHITNSMSLFRIYLSIFLSIYLSQYIHIYLSIYLSLCSKSIYLPNYVSKLSISLCFESINLSIYLSIYLSIYLFHYIRLSIFRTRLLLILFNHSVPPRPPKYIRDFCSSSFISFPHLFFLFCLSFCLSFFLSFFLSFHLIFSYNYFSFFFSFFFLYHFVSAHLSSFLSVFLSFFLSFFLSFFPFFEFYTIIISFSFSSLSFFLSFFLSFFLSFFPFLSFFLSFFLFLFLFYLPFGLSPSFFLPFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C2G9</accession>
    <name>A0A812C2G9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_27103</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001041">
        <property type="protein sequence ID" value="CAE1250423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C2G9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1250423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="282" mass="31644" checksum="7B7152054AFF1515" modified="2021-09-29" version="1">MSTLSIYLSIYLSIYLSISVCSYHSSIYLSIYLSIYPSLFSCSSQSFLSLSLSLSIYLSLFISIYLSIYLSIYLSIPVCSQVPLNLSLSLSLSLSIYLSISVCSYLSIYLSIYLSIPVCSHVPLNLSLSLSLSIYLSISVCSYLSIYLSIYLSIYPSLFSCSSPIFLSLSLSIYLSISVCSYSSIYLSIYLSIYLSLIISIYLSIYLSIYLSIYLSIYPSLFSCSSLSLLSLSLSLSLYLSIYLSIYFSLFISIYLSIYLSLFSYSYLSIYLSIYLSIYLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C2H8</accession>
    <name>A0A812C2H8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_27215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001046">
        <property type="protein sequence ID" value="CAE1250586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C2H8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="299"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="329"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="361"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="403"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1250586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="422" mass="51098" checksum="EA3DC427289BD5A7" modified="2021-09-29" version="1">MLHMLNDIFMLVIYITCFRYDRRGIQSVIGHSIHVSFFLSFFLSFFLSLICLSSLFFFEIFISFSLSLSMNFLFLSFGLSFFLSLVFLTTLLKYSFSFCCLSYSLIYYFLSFFRSFFFLLSLLLFKVYFSFFLSFFQSFFLRLSHLLLKHSFSFFLSFFLSFFLSFFSLSNSLKYYFFLSFFIISFFLYSLLLFESLLLFEVFFSFRLSFYLSFILSFFSLSEIFVFFLLSLVLLTLCSFLSFFLSFFLSLILSFFLYILFLSFFHSFFLSFFLSFLSLSYCLNYSFPFFFSFFLSFKATFLLCSFFNFFFLHLSFVSFFLVSCSRFTFMFLFSFFLSFFLSLNFFFLFLISYFFLFSEHFLSFFLSLFLSLCLFFFFLLPFFLSRSLTYYYLFRFLHFFPDYNLLLSFAPSLLLVTYSGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C2J4</accession>
    <name>A0A812C2J4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_28683</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001125">
        <property type="protein sequence ID" value="CAE1253916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C2J4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1253916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="252" mass="31059" checksum="4DD01A891DC5622D" modified="2021-09-29" version="1">MDKGNSFVFSFHKLSILVLSFLFFNSGFFFLSSLYSFLINLNYSSFHFLHFYFDSLFLLLCSFFHFISFSFSLFYSLFLFLFFNVFILVNRSFLLYPRFFLVTPFYFLIFLFIYLCFFRLLFLLSFLIFPPFSSSFYFYLLLLASFLNFERVFFFLIRIFFNRLYFLFYFFYSFFCCIFSFFCDFHISFFHIIVVSIFYIFLFIFFLLHIKTFFSIPFKIFSYKSSFFLFSLRLFYSSFFLSFDMSSLISSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C3U7</accession>
    <name>A0A812C3U7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_30820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001246">
        <property type="protein sequence ID" value="CAE1257573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C3U7"/>
    <dbReference type="OrthoDB" id="7387685at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47018">
        <property type="entry name" value="CXC DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47018:SF1">
        <property type="entry name" value="TESMIN_TSO1-LIKE CXC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1257573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="502" mass="57107" checksum="0EE8FB89BC1A6697" modified="2021-09-29" version="1">MFGGLHIEMTALKSIGSMRADCGRTNAFAEVDVASSGTADSFLSATNVTKTRQAHQVTECSLFQLLKKVYSSYLAEHSDGDEEASSFVEWWDSRKKESAQFAFWFSILNMELTILTLVRAFREGNFNLYRESLSELIPYLFANNNANYARWLPIHLRDMISLEKQYSEVAREFHNGNFVVHKTDRKFSAMAIDQAHEQNNAVIKGDGGAVGLTEDPSALRRWMVAGPEISKFVADYEAVSGSKEAKKGSHHHEQSPTAQTAFFEKVQRLTSVIEEMGNPFSEESTDLLSLDTKDIADPIATLLVASHLEEGKEQFQTFHKHKVSQHFYQPIKRNNKDFFKTSTDPTEKSETQLLKEDCQLFSRLFISCQSRGCDLPEFFKHENQSFPPPLSKRGKLHVATKSDLVDVLQTKVELPDTKPETDVLIVDGAFLVNTVTPRTPKTFEEYARQDILPKVQYYSNNYKRTYIIFDVYHESSLKFEARSKRGKAIRRRVTAKSKTPTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C552</accession>
    <name>A0A812C552_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase Pif1-like 2B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_29720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001189">
        <property type="protein sequence ID" value="CAE1255633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C552"/>
    <dbReference type="OrthoDB" id="1728974at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049163">
        <property type="entry name" value="Pif1-like_2B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492:SF57">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21530">
        <property type="entry name" value="Pif1_2B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="298"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="325"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="368"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="DNA helicase Pif1-like 2B" evidence="2">
        <location>
            <begin position="60"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1255633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="432" mass="51358" checksum="760B1E3A4AF8286F" modified="2021-09-29" version="1">MSDDVLFCVHRNCPGVECGFTDFIFNRALVALDDVFELGGASLPTYGLPSQLRDGFVTPPGLPPHILRLKVGAPIILIRNLLPTKQCNVTRLIIKSLSPNLIEATIATGCGKVFFIHSFHLLFLLDFNISFFLFPFEFYLHIFIFVAIVPFFLFKIMLSFFFFLSFFLSFFLSFFLSFFLCYIFVFCLVFFSFYHLSFFFFHFRSFSWFYPSLSFFIFSLLHFPFFLSFFISFSMLHFHSFAWLFSLPSLSLFSVTFSFFCLSSFLSFFLSFFLSFFFFPCFISVLSFFFFYHVTFTFFYLLSFFLFSLFAFFFFFHFYSFTLAFHLSVFLSVGIILPVLYFRSFVRLFLSSFFFWQSVLHFRSFSPFFTFFLIPYFTFCSFFFFLLFFFSLVFSSISDPPPELPPHQYVRVHVSLILISHFSSYGFCYIFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C655</accession>
    <name>A0A812C655_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_30296</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001217">
        <property type="protein sequence ID" value="CAE1256640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C655"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1256640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="413" mass="50858" checksum="80AA1A9AF6AB20CB" modified="2021-09-29" version="1">MIAFIFLFLFLLFDHFLYFPFFYILLSFFLSFFLSFFLSFFFLSFFFTFCCLFLYFLSFFLFLSFFSFSFFLLFSFAPFFFLVSFLFFFCLFYILFSFFSFLFFFLSFFLSFFLYICTILFFLSCEFIFFFFSFIFFLFSFFLFTFLFFFLSFLFLLCHLFFLLSFLCLFYPVNSFFSFFLSFSFFLFFLSFFFLSFLHLHHSFFFYLIFLFFFFFFFFYSFFYLLSFFLSFLCHLSFSFLSPLLFYPLFSFLISFFIFSFFFYLPTNFFILLSFSFSPLCVTEILLIHKDLSFNIFLSFFLFFLFCLFLFLLFFLYHNLKFSSFLVRHSLLFVFLRHFFLSFFLFFSFIIICFLSLKQIRMRKQFRLAKTKARICDQLLSMGEGAGGRMRPPGNGKQLLITTLLFASCEGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C6G7</accession>
    <name>A0A812C6G7_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Acyl-coenzyme A oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">SPHA_30982</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Farmed</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the acyl-CoA oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001255">
        <property type="protein sequence ID" value="CAE1257927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C6G7"/>
    <dbReference type="OrthoDB" id="538336at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005504">
        <property type="term" value="F:fatty acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016402">
        <property type="term" value="F:pristanoyl-CoA oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033540">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA oxidase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000007">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000010">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000005">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055060">
        <property type="entry name" value="ACOX_C_alpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012258">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002655">
        <property type="entry name" value="Acyl-CoA_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909">
        <property type="entry name" value="ELECTRON TRANSPORT OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909:SF390">
        <property type="entry name" value="PEROXISOMAL ACYL-COENZYME A OXIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01756">
        <property type="entry name" value="ACOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22924">
        <property type="entry name" value="ACOX_C_alpha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000168">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11 13" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="15">
        <location>
            <begin position="29"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase C-alpha1" evidence="16">
        <location>
            <begin position="175"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase C-terminal" evidence="14">
        <location>
            <begin position="384"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="324"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR000168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000168-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000168-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF22924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAE1257927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="579" mass="64719" checksum="A59575CB58F5681C" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C7H7</accession>
    <name>A0A812C7H7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_30935</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001251">
        <property type="protein sequence ID" value="CAE1257809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C7H7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="378"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="408"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="457"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="491"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="520"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="553"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="575"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="601"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="629"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="661"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="688"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="717"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1257809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="755" mass="87044" checksum="80498343267F941E" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C8S7</accession>
    <name>A0A812C8S7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_33364</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001395">
        <property type="protein sequence ID" value="CAE1262724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C8S7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1262724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="163" mass="18876" checksum="CAB37FC2F2CF87A5" modified="2021-09-29" version="1">MHSPSNKHPPSNKRPFSNKHSPNTHPPSNKHPFSYKRLSSNKYPSSNKHSSNTHPPSNKRPFSYKRPLSNKHPSSNKHSWNTHPPSNKRPFSNKRPPQISTLPQISTLRIRTLHRISALPRISALYRISVPSRVVEYALPSNKRSLEFASRHNRKKIYVLNFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CBU7</accession>
    <name>A0A812CBU7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_34888</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
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            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001491">
        <property type="protein sequence ID" value="CAE1265854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CBU7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1265854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="238" mass="28862" checksum="85FE7CC5D7F893D6" modified="2021-09-29" version="1">MHFFPSFFSFSFFFLSFLHLFFFSFLFLFAFSSLLFFLSFFLSFFLSFFLSFFLSPSFFFSFSFPCIFFLSLLSFFLSFFLSFFLHLFSFLFLFLSDFIVFLFSSNAFSSFLFFLSFFLSFFLSFSIFFLFFSFSFPSVHFLFSFSFFLSFFLSFFSFFLSFFFFFPSFFFFFLFLNAMCMHIHHSNLSLSLSLSIYLSIYLSIYLSIYLFHSVPIYLSIYLSIYLSIYPFISSVSRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CEY8</accession>
    <name>A0A812CEY8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_34023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001435">
        <property type="protein sequence ID" value="CAE1264083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CEY8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1264083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="247" mass="29532" checksum="26CA8ECC492CF8ED" modified="2021-09-29" version="1">MIPELTDSLPFDSAFIHLRLPKVSIYLSIYLSIYLSIYLSIAVYFYLFQSAQIYLSIYQSIDLILFISIYLSIYLSIYLFIYLSQSVSTYFHLLKSIYLSIYLSIYLSIYLSIYLILFISIYLSISFSSYLSIYLSIYLSQSVSTYFHLLKSIYLIFLTLYMYISFTPFLSFFLSFYLSIYLSFFLSTSRFLSIYHIFFYLPMNMSVTVSFFLPFFLYFYLSIYLSIYLSIYLSIKHILFVLQIYQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CF89</accession>
    <name>A0A812CF89_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_33099</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001385">
        <property type="protein sequence ID" value="CAE1262240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CF89"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1262240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="224" mass="26286" checksum="84D7E7AB968734CD" modified="2021-09-29" version="1">MSLLRLSIYLSIYLSIYLSIYPNLLISLSKTFSLSLFVFKPVHIYLSIYLSIYLSIYLSIYPKLLSLSLYLNLFISIYLSIYLSIIMCPYHLVIVVCIRLPFHRTSINILCFLSFFISLLALVSFISIYLSIYLSISIKLASYQDCSYLSIFYLSISIYLSKVYSYLSIYLSIYHLSIYKSKSIHIYLSIYLSIYLSIYLSIYIYSYLSIYIYLSIYLISIFST</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CG22</accession>
    <name>A0A812CG22_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_38596</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001757">
        <property type="protein sequence ID" value="CAE1273974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="571"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="610"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="653"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="691"/>
            <end position="712"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1272023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="713" mass="80399" checksum="25E6391AD6525070" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CM08</accession>
    <name>A0A812CM08_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">PAX1_9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SPHA_39688</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001860">
        <property type="protein sequence ID" value="CAE1275840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CM08"/>
    <dbReference type="OrthoDB" id="3225452at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001523">
        <property type="entry name" value="Paired_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043565">
        <property type="entry name" value="PAX_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636:SF16">
        <property type="entry name" value="PAIRED BOX POX-MESO PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636">
        <property type="entry name" value="PAIRED BOX PROTEIN PAX-6-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00292">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51057">
        <property type="entry name" value="PAIRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0563">Paired box</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="309"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="341"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="375"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="411"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="439"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="477"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="Paired" evidence="10">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAE1275840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="501" mass="58651" checksum="1CE7728B95C21AB2" modified="2021-09-29" version="1">MYKEKDPGIFAWEIRDKLLADAVCDKYNVPSVSSISRILRNKIGNSNHNNTSNNTTQPASPQYDKNPTAAPLYNQFYPYTCPAQAIPTVPTPQHPSQTGSLPLNTKPGAMSAVTPCMMRAWPSSHTVNDILGFRPPQSMSQPAPPMDTTIGQNYNYYGVNVKSAAVSPITYFLTCYLVSFVSFFSFHHSIFSFFLYFTVLFFPFFLCSHIFFFNSYFLSFFFLFLLFLSFLFRSFLPFFGLSSFLGSFFPSFLGSFFLSFLSWFVLSFLPFLVLSFRSFLVGSFFLSVLSFRSFFLSVLSWFFLSFFPFFLGSFFLSFFPFFLGSFFLSFFLSFFLSFRSFLVLSFFPFFLSFFLSFFPFFLSFFLSLFLSFRSFLVLSFFISFRSFLVLSFFLSFRSFLVLSFFLSFRSFLVLSFFLSVLSWFFLSFFPFFLGSFFLSFFLSVLSFFLSFFLSFFPFFLSFHLFFRTFFPSFLRSFFPSFPTFFLSVIPYFLSFALLFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CQC7</accession>
    <name>A0A812CQC7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_39792</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001868">
        <property type="protein sequence ID" value="CAE1276071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CQC7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1276071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="203" mass="23202" checksum="4BFB30D1D06CB267" modified="2021-09-29" version="1">MFTCEQINLSIYLSIYLSIYLSIIYNAFHIYLSIYLSIYLYSSSSPLRHLPSTGKSWRKRYGTDGGKGGNERRDEDGKRRRNRARLGRRKEARNSPPEPLSPRHLSQNRCPPTRSLAFAAPSGFFLGPCFKTGLVGCRCTSRTRGDRWHSQTPTYQCPPARPDFCVRTRRRRRDETTSRAGTGIDAAAKVSKLPRTLSRARPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CV03</accession>
    <name>A0A812CV03_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_44026</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002230">
        <property type="protein sequence ID" value="CAE1283388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CV03"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="61"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="242"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="68"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1283388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="287" mass="31419" checksum="22A29FFB7B23790C" modified="2021-09-29" version="1">MPSTSTSVTTYRPEIEMVDLIKCETRSTSPSIISDNSVNDCPLEERLKSENQLEVSLNLPLASDQETENMVASAGSTSSIRPSSKNNSTNNSNEEPSSEPLIESLPSSVHAEKLEIVSISSIHDPNPSNVTTVIEDIDLNRQESYTISKNNPKITAPTSVVPTTTSDGKITDRVPTISPATTASIALTALCQSTLLTSNTSSCRLGNLSSKSHKQSVDELGVDEPSQKRLKSIPPEYLELHQAVLLLEKEKLQIEIEKMKREVVNQEKMTEILDIAKDVFVSLREKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CV73</accession>
    <name>A0A812CV73_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_43855</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002223">
        <property type="protein sequence ID" value="CAE1283077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CV73"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1283077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="204" mass="22074" checksum="D0C30CC522EE2731" modified="2021-09-29" version="1">MLIASDNIISSATGIQQGDPLGPLLFAMAIDGVARSIASPFNIWYLDDATLGGSIEAVAADLRRVIPALSLLGLEINSSNPLLLEERSFATEFPLHSPKCPCYLEQDFLNEIDITIKRCAELIYNVNFDDTGWRQAKFPLSFGGLGLRSAVDLALPAYLSSLSSSRELIDEILGGSSQCFSGSSFEQACSVWVQELLSIPLDIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CV94</accession>
    <name>A0A812CV94_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SPHA_40509</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001913">
        <property type="protein sequence ID" value="CAE1277228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CV94"/>
    <dbReference type="OrthoDB" id="10066958at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75011">
        <property type="entry name" value="3-carboxy-cis,cis-mucoante lactonizing enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="7"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="6">
        <location>
            <begin position="143"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAE1277228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="630" mass="70910" checksum="0EC1FB84A8B6B2ED" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CWH8</accession>
    <name>A0A812CWH8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_42839</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002112">
        <property type="protein sequence ID" value="CAE1281335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CWH8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1281335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="253" mass="29255" checksum="F02C6E49622AE054" modified="2021-09-29" version="1">MDKSVLAHTSKNLYHLHICKHAHKIFLSLLHIPFPSLSLSLSLSLFLLQTLSPSFPSVNKSVSRDCFYLSHFLCVCARVRGRVYLRVFARDIFYLHANLPPPLPPVFLFFIHTFSLNFLILLLPHILSPFLSPGSCNILFTPYLSYPKTLIFWADFLRRQTLLPSLPSPWWAFAFLSQTFPAQWIGYMPIVALSSQMTIHQCWKCDILSTPFPILPPSLSLSLSFRHFIYLSLSSLYHFISFFSFARVHARFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CXB3</accession>
    <name>A0A812CXB3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_46448</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002451">
        <property type="protein sequence ID" value="CAE1287231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CXB3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1287231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="330" mass="40025" checksum="AE0F28F29329C9A6" modified="2021-09-29" version="1">MFLCSAAIFSPFSANFFHLLCFFSYSAPFFSPLLCRRPIFFLQASYFQSFAFASVLFLSFQSCSAKYPVLFLHVCERPYFQFLERPNSFALRFSSVIIFFAHLFNIYLFCSAPFLQILSFALQAFLALRALFLVPFFQSFFCDYFQSFALQASFFQFFFFPIFLLPFSSFPSFSVLFCERFFPPAFFQSFVCKFFQSSPSFFLFFFFFLFFPYFFFFFLSLFFFLLSFFLSSFHFFSFLSLFSILFLFLFFSLSFSFHLFFLFFSSTFHSFFFFFFLSFANFFHFFFFFLYLLFMLFYFHFLSLFHSLTFILSFFKTVIIFQFPNISFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CZ02</accession>
    <name>A0A812CZ02_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_42790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002108">
        <property type="protein sequence ID" value="CAE1281269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CZ02"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="337"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1281269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="362" mass="41363" checksum="16C83C66B5E8BD77" modified="2021-09-29" version="1">MLPNFQRSGSLITIPYRRFAIPYNQPSFRKSRLTRDVSGLNQDSSESSELNMRDESENSSEESMEDNTSSSLGKRGLRSNAMLPIYQQPEVNPFETMKNIEHKDFSTNHGGMNKEADDSSTGNADVHPLDTIQGGPGSYQHVFVGPSSKSNDAEPLYSKRPEDNDNSDEDSLSRGLSDQNPALINEDFLVKDIAYDQTADKTLEGQTYRIADLDDGTSMNGIYTNGEQAKRFNDGMQEIVNALGGQSASRGSGRGRDDRRNDVWTDVDVFDWKSQANVEPSISFFPFLLLFSFCFIFFQSFFFLFLSFFPRYLFHSVFFSIFSYLSSFFYFSFFHSFFSFLFFFPFLSFSLSFFPSVFRPFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CZR0</accession>
    <name>A0A812CZR0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_43319</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002168">
        <property type="protein sequence ID" value="CAE1282248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CZR0"/>
    <dbReference type="OrthoDB" id="1421090at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134:SF22">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134">
        <property type="entry name" value="OS08G0543275 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
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            <end position="221"/>
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        <location>
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        </location>
    </feature>
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        <location>
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            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="321"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="351"/>
            <end position="373"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="401"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="432"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="438"/>
            <end position="454"/>
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        <location>
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            <end position="483"/>
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        <location>
            <begin position="489"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="517"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="543"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="576"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1282248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="609" mass="72904" checksum="4BE704D6FEE89E58" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D2K5</accession>
    <name>A0A812D2K5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_44085</name>
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    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
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        <dbReference type="NCBI Taxonomy" id="158019"/>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
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    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D2K5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
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        <location>
            <begin position="42"/>
            <end position="61"/>
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        </source>
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        <source>
            <dbReference type="EMBL" id="CAE1283480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="500" mass="59283" checksum="3EFE9F4356C1E866" modified="2021-09-29" version="1">MTQQPVYTGFFLFYCFHISFFFFFFLSIFLSLFTFLSFFDSIFLNFCISISFFFIVRYYFLSFSFFSFFNLSSLILSFFLSFFLHSFFLSFFTLCSIFLFYLSFFLFLISFFLLSFFLSFFTLCSLFLSFFVRYFFHCFFFFRSFVLSFFLSFFLSLFFVRYFFSFFLSFFLSFFPFLTFFFFLSFFLYTLFAIFSFFSFLPSFLACLLPSFLSFSLLPPSLLSFFLSFFLSFFLSFFLSFFLSFFILCSLYFLSFFLSFFLSFFLSFFLSFFLSNRPHFLTLFFPGVDGWFNGSLSLSLHLSIYLSIYLSIRVWTDGSMDLSLSLSSSIYLSIYLSIYLSIRVWTDGSMDLSLSLTLSLHLSIYLSIYLSIYLSISIYLLLGVDGWFNGSLSLSSIYLSIYLSIYLSIFRGVDGWFNGSLSLSLHLSIYLSIYLSIYLSIYLLGCGRMVQWISLSLSIYLSIYLSNSLHIYLSIYLSISVCLYLSIYLSIYLSIYLSIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D384</accession>
    <name>A0A812D384_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_45815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
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                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002385">
        <property type="protein sequence ID" value="CAE1286130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D384"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        </location>
    </feature>
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        </location>
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        </location>
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        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAE1286130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="184" mass="17602" checksum="92DB14673D60B7C8" modified="2021-09-29" version="1">MSATSTVPSDIASTSASTPAMSATSTVPSDIALTSASTPAMSTTSTVPSDIALTSASTPAMSATSTVPSDIASTSASTPAMSTTSTVPSDIALTSASTPAMSTTTTSTVPSDSSIISIPAMSTTSTVPSDIALTSASTAAMSTTSTVPSDIALTSASTPAMSTTSTVPSDIASTSASTAVNVSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D631</accession>
    <name>A0A812D631_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_45948</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Cephalopoda</taxon>
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            <taxon>Decapodiformes</taxon>
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            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002401">
        <property type="protein sequence ID" value="CAE1286350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D631"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="75"/>
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            <begin position="110"/>
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            <begin position="145"/>
            <end position="166"/>
        </location>
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            <end position="196"/>
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            <begin position="202"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1286350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="236" mass="28831" checksum="AA3DDA7DCE58C417" modified="2021-09-29" version="1">MRALLFSVEVALEFQLKPPPVRFKRESRRNTVLQEKNHARKPANGYFFLFFSFFHFFFLSLFFLSFSSFSLFSLFHFFFLSFFFLSFSSFSLFSFSLFSFSLFSFSLFSFFLFSFFLLVLSLFFLSFIFSFFLLVLFLFFFLSFFFLSFSYFSFFFLSFFLSFFFLSFSSFSLFSFFHFSFFLFFFLSFSSFSLFSFFHFSFFLLLLAFFFLSFIFSSFTSFLLSYFFLSFFIAFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D6A3</accession>
    <name>A0A812D6A3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_46790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002495">
        <property type="protein sequence ID" value="CAE1287840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D6A3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1287840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="160" mass="18838" checksum="5BD0197109DDF21B" modified="2021-09-29" version="1">MRNENKKKKKIDNYNDLNLFIIYLSQFVHYLSIYLNYLFLFLSIYLSIYLSQSVHYLSIDLSLSLSHTHTHTICSLSIYPNYLFLFLSIYLSLFIIYLSLIIIYLSIYLSISLSLSLSLTHTHTHTHNLFIIYLNYLFLFLSVCLSVYLSQSFLSISIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D808</accession>
    <name>A0A812D808_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PHD finger protein 14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SPHA_47638</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002598">
        <property type="protein sequence ID" value="CAE1289381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D808"/>
    <dbReference type="OrthoDB" id="6287393at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15562">
        <property type="entry name" value="PHD2_PHF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24102">
        <property type="entry name" value="PHD FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24102:SF28">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="8">
        <location>
            <begin position="222"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="313"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="121"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="318"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="335"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAE1289381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="355" mass="40630" checksum="9F83BB1099CE2519" modified="2021-09-29" version="1">MPYARWGAKECSLCEDSRFSRTGVCISCDAVFFPLFSFLIPLLFFLCLFCCFLLANLQPLSPFYVLGIRPLLTGFSSSFLLRGISIQNVSQDKQETRKKWHMSPALSLEFISYYLDRNARMDTMKINMKELSSQNDKLQEQQKVLRVQYDQLLNEMNRLKDSTSKLQQNGEETWGILTDLSGQELNIPEMFRVRKSPRSPTKRETHPKSPPAPAIQQYNLLIGSCGICKKSTDQHLLAKCDSCSKHYHLGCLDPPLSRMPKKTKLQGWQCSECASSSSDVSEETGVDVDAPRKLREKIKEPIKFEQLQSLDIKSEKRLRNRSNTKQKKGKKRKSVKADKGGKREDHEDSEGVMEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DC88</accession>
    <name>A0A812DC88_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_50733</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003010">
        <property type="protein sequence ID" value="CAE1295101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DC88"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039715">
        <property type="entry name" value="ZCCHC10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13491">
        <property type="entry name" value="ZCCHC10 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13491:SF0">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="240"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="291"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="325"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="393"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="423"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="449"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="509"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="542"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="572"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="661"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="729"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="762"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="800"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="831"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="914"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1295101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="936" mass="104762" checksum="4745E80BE174BBAC" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DCM7</accession>
    <name>A0A812DCM7_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar protein sorting-associated protein 53 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SPHA_53417</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VPS53 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003402">
        <property type="protein sequence ID" value="CAE1299824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DCM7"/>
    <dbReference type="OrthoDB" id="10261632at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.110">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 53, C-terminus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039766">
        <property type="entry name" value="Vps53"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031745">
        <property type="entry name" value="Vps53_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038260">
        <property type="entry name" value="Vps53_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007234">
        <property type="entry name" value="Vps53_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12820:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 53 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12820">
        <property type="entry name" value="VACUOLAR SORTING PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16854">
        <property type="entry name" value="VPS53_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04100">
        <property type="entry name" value="Vps53_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vps53 N-terminal" evidence="8">
        <location>
            <begin position="42"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Vps53 C-terminal" evidence="9">
        <location>
            <begin position="528"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAE1299824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="675" mass="76761" checksum="9D06B6BC52C673A8" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DF84</accession>
    <name>A0A812DF84_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_50768</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003014">
        <property type="protein sequence ID" value="CAE1295145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DF84"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1295145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="175" mass="20704" checksum="22B23872D5C9A782" modified="2021-09-29" version="1">MFSLLARFLSSFSIVQSHLSFSSLYHTLFFSLISPVVLYRTFLSFFLSFFLSFFLSFFLSSPSYTLIYAFLTIHSLTSLSYLLYFTLDFFFLLLQLLPFFLLHRILSSFLFYDSLINFSLLSPVLLHLILSLYLSFFLPFFFSSFLSSFLSSFLPFFLPFFSIVYSHLFFLSFIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DFD2</accession>
    <name>A0A812DFD2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_54207</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003505">
        <property type="protein sequence ID" value="CAE1301129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DFD2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1301129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="197" mass="23246" checksum="68A3E91AC1F5A491" modified="2021-09-29" version="1">MVNIFNIVSLLFLHLHFLPHLLPHLLLLLLFLIIFYFFFFFYFHFYFSSIFIFFIYYIFISSTSIFIFISFSIFISSSSVIICLLSFLFFLFLKFLLFLLYLFLLILFHLPILFLLLILFLLLLLPFLFLLLILFLLFSSSIFISSSNFISSFIFISSSNFISSFSSSIFISSSNFISSFSSSIFISSSNFIPSFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DIP6</accession>
    <name>A0A812DIP6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_53793</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003432">
        <property type="protein sequence ID" value="CAE1300278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DIP6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1300278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="208" mass="23676" checksum="EFE923DC700BAF1B" modified="2021-09-29" version="1">MNVLKTCVDVSIYPHLYPSLSLPIHSSIYLFIYLSIYLFIYLSQSVHINQFISVCFYLSIYLSIYLSQSGHYLSIPTALLLSGPFFLSFFLPSFLPSFISIYLSIYLSHILTVTHRNAYNFGTYNSVSTPSQQCNNELTYGCEWSSRKVITPEAVFFSFFFILATRLETYHPRPLHFSSCLHRPISVCPCISPDASLSGLAPRPLFGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DJU1</accession>
    <name>A0A812DJU1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_57323</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003863">
        <property type="protein sequence ID" value="CAE1304789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DJU1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="232"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="272"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1304789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="310" mass="29994" checksum="F0DD4417B996A7E0" modified="2021-09-29" version="1">MLATSTVPSDIASTSTPTPAMSATSTVPSDIASTSTTTPAMLATSTVPSDIASTSTPTPAMLATSTVPSDIASTSTPTPAMLATSTVPSDIASTSTPTPAMSATSTVPSDIASTSTPTPAMSATSTVPSDIASTSTPSPAMSATSTVPSDIASTSTPSPAMSATSTVPSDIASTSTPIPAMSATSTVPSDIASTSIPRPAMSATSTVPSDIASTSTPNPAMSATSTVPSDIASTSTPTPAMSATSTVPSDIASTSTLTPAMSATSTVPSDIASTSTPTPAMSATSTVPSDIASTSTPVLQCQPLVLFLQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DKD4</accession>
    <name>A0A812DKD4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_55284</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003667">
        <property type="protein sequence ID" value="CAE1302897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DKD4"/>
    <dbReference type="OrthoDB" id="9635126at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1302897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="275" mass="32612" checksum="1B0F888A67760DB9" modified="2021-09-29" version="1">MLIYLSIYLSIYLCVFISIYLSIYLSIFVYSYLSIYLCVFISIYLSIFVYSYLYIYLSIYLSLCIHIYLSIFVYSYLSINLSIYLCVFISVYQSIFVYSYLSIYLSQFFSYLSIYLCVFISIYQSIYLSVFISIYLSLSIYLSIYLSIYLSIYLCVFISIYLSIYLFKCVHIYLSIYLSIRLSQFSSYLSIEISSYLSISSYLHIYLSIYLSISPVHVFICLYLSRSVHIYLPTYLSIYLAPIYLSIYLSIYLSIYLSIYLSLFIICPNLSFNFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DMY8</accession>
    <name>A0A812DMY8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TRIP4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_56632</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003762">
        <property type="protein sequence ID" value="CAE1303926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DMY8"/>
    <dbReference type="OrthoDB" id="338816at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056994">
        <property type="entry name" value="TRI4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039128">
        <property type="entry name" value="TRIP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056993">
        <property type="entry name" value="TRIP4_3rd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12963:SF4">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12963">
        <property type="entry name" value="THYROID RECEPTOR INTERACTING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23135">
        <property type="entry name" value="TRI4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23134">
        <property type="entry name" value="TRIP4_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Activating signal cointegrator 1 N-terminal" evidence="2">
        <location>
            <begin position="2"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="Activating signal cointegrator 1 third" evidence="1">
        <location>
            <begin position="140"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1303926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="244" mass="28162" checksum="AE1592B2F0718A6C" modified="2021-09-29" version="1">MEHWICVELSKLGVDVTEENARYIIAMEGDQDMEDYLFDLLDKSDPKEGAGVCLFCGNLVCSKEQQKILSEGTKRSEKLHQTLMKDSDKVLQQINNQILQISKNSASYAESEEFSKAIEYKNRLLDYDKTSVKRTHVIDDDADYFSSDSQWLSKSEREALERCEEELRQIRFQSRREVKVTFDFAGRRILDANENNAFSLNNMYEDQKTAALEAKQIALIDTKDDNFLPRDLVNPAVNMHVPQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DPT0</accession>
    <name>A0A812DPT0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_56794</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003794">
        <property type="protein sequence ID" value="CAE1304201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DPT0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="340"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="383"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="417"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="469"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="587"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="617"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="645"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="674"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="706"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="744"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="776"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="495"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1304201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="800" mass="91516" checksum="9703D5872C23DADF" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DTZ0</accession>
    <name>A0A812DTZ0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_60766</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004241">
        <property type="protein sequence ID" value="CAE1308936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DTZ0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1308936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="237" mass="28302" checksum="27E431B478972987" modified="2021-09-29" version="1">MFHLTVIKAAGRRSGSISIRLLRTALKTLNLILRDEYISAKPGLLAARRNVLIIVFSFFLSFFLSFFLSFFLSFFCINLPFFIYPFLSFFFLSFFISSELIYFSFFIFCNNSFFLSFFLSFFLLHIFIFSFSSIDFIFFPSTDFFFLFFHIFHSFLFFLSFFPFILFSLFSLSSLNTSLFSSSTYLSFQKTSFLEILYCFRFLFFFLSFFLSFFLSFFLSFFLSLTLSLTLFFIYSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DUM6</accession>
    <name>A0A812DUM6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DHRS1</fullName>
            <ecNumber evidence="1">1.1.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_61137</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.-.-" evidence="1"/>
    <dbReference type="EMBL" id="CAHIKZ030004296">
        <property type="protein sequence ID" value="CAE1309386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DUM6"/>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44147">
        <property type="entry name" value="DEHYDROGENASE/REDUCTASE SDR FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44147:SF2">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1309386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="250" mass="27783" checksum="E90898E5F9133DAC" modified="2021-09-29" version="1">MNTLSGKVCLVTGASRGIGKGIAIQLGEAGATVYVTARTLQRDNDVPWKGSLEETVEEIEVRGGKGIAVQVDHSNEDEVKMLFERIRREQNGQLDLLVNNVFSAIKVIIQNIGSPFWDQPFSYWDEVSHVGLSHIVFICRNHYLCSVYAAQMMVPRKQGLIVNVSSAAGLFYTYSVVYGVCQEARKLESNILHGETPEYIGKCIVHLLRDRAILKRSGHVLLTADLGDDYGFTDVDGKFLNFCPSKTRKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DV22</accession>
    <name>A0A812DV22_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="20">CACNA1G</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">SPHA_59094</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">Farmed</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Membrane</location>
            <topology evidence="1 16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004089">
        <property type="protein sequence ID" value="CAE1306999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="416585at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
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</entry>
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                <person name="Bekaert M."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </evidence>
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        </source>
    </evidence>
    <sequence length="274" mass="31133" checksum="72A914602BC71320" modified="2021-09-29" version="1">MNQYSMSFPSLVSIYLSIYLSIYLSLSLYIYISIFETCFFPPLSFHLSLSLSPLPPLTLFPPLSLFPPPTLFPPLSFHFPLNFAPLSLHLLSSISLSFSLCFPTPLSLSFSLYSFFHLSFTFSLLPPLSLSFSLSSFFHIFPFLSTPVYPLSLSSFSSSLYLLSFSLLPSTSLTHLLFIFFLSCLFLSVLHHPLFLCFSLFDLSFSFLFIFSHSSFSSSFSLLPNPSFNYLLFIVFHLSFTFSLLSLSLSFSSFFHLSFTFSLFSTPSPFHIQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DY72</accession>
    <name>A0A812DY72_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_62087</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004404">
        <property type="protein sequence ID" value="CAE1310487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DY72"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="320"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="344"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="376"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="401"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="428"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="469"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="502"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="537"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="576"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="621"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="684"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="715"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="747"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="782"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="816"/>
            <end position="837"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1310487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="897" mass="106872" checksum="CE79E48CBFF97101" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E077</accession>
    <name>A0A812E077_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_65857</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004740">
        <property type="protein sequence ID" value="CAE1314878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E077"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1314878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="180" mass="22498" checksum="BF1A41CBD4AB3748" modified="2021-09-29" version="1">MCVWLIVFFSIAFRLFYFFSFFFFLSLYLVTILSFHFLSFFLSFFLFFFLSFFLFSPAKLFTLFIHFFFHSTLPVFFYFLMFSFFLSFFLSFFLSFFLSFFLSFHSFLILLFQVCHFSFFFLLKYLFLTIDYISGLIFNFSFYFFSMFCFVSFCFRFFFLSFFLSFFLSFFLSFFLFTHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E1T1</accession>
    <name>A0A812E1T1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_66727</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004817">
        <property type="protein sequence ID" value="CAE1315873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E1T1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1315873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="187" mass="21940" checksum="AB8554997EA55D7B" modified="2021-09-29" version="1">MSKDVIPISIYLSIYLSIDQLPFIFFNSFLLLLISIYLSIYLSIYLPFLSHILPPSLLPSILPSILSIYLSIYLSIYLSICSFLFFFLSIYQYIYICQLPSKSVNSYHSLLSFNFFLLLLISIYLSIYLSIYLSIYLSVLTALHFFLSFFLPSYLSIYLSIYLLITFHIFKLFSFVNIYLSIYLSMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E1W3</accession>
    <name>A0A812E1W3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_64073</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004613">
        <property type="protein sequence ID" value="CAE1312900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E1W3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="400"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="472"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="504"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1312900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="526" mass="59480" checksum="2630B26DA2FA02E3" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E2K0</accession>
    <name>A0A812E2K0_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ANK_REP_REGION domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SPHA_66058</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004759">
        <property type="protein sequence ID" value="CAE1315094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E2K0"/>
    <dbReference type="OrthoDB" id="6094629at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173">
        <property type="entry name" value="ANKYRIN REPEAT CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173:SF74">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="738"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="772"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="809"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="875"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="904"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="926"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="960"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="992"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1017"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1060"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1084"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1108"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1141"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1170"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="58"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="350"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAE1315094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1194" mass="136582" checksum="53C9FF6D5D55C82D" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E7L5</accession>
    <name>A0A812E7L5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">GRM5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SPHA_68577</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004998">
        <property type="protein sequence ID" value="CAE1318086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E7L5"/>
    <dbReference type="OrthoDB" id="6133044at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13953">
        <property type="entry name" value="7tm_classC_mGluR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.30">
        <property type="entry name" value="GPCR, family 3, nine cysteines domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000337">
        <property type="entry name" value="GPCR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011500">
        <property type="entry name" value="GPCR_3_9-Cys_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038550">
        <property type="entry name" value="GPCR_3_9-Cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050726">
        <property type="entry name" value="mGluR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24060">
        <property type="entry name" value="METABOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07562">
        <property type="entry name" value="NCD3G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00248">
        <property type="entry name" value="GPCRMGR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="377"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="419"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="442"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="489"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="11">
        <location>
            <begin position="376"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAE1318086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="514" mass="58115" checksum="3B3AA8C0F04970B6" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E8C4</accession>
    <name>A0A812E8C4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_66301</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004782">
        <property type="protein sequence ID" value="CAE1315368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E8C4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1315368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="231" mass="27205" checksum="092A4D5D4DAEF95D" modified="2021-09-29" version="1">MSPKRCLLFIYLSLFLYLSIYLSIYLSIYLSIYKTVARIKVPCATFYPRGWIDKYHLSIYLSIYLSIYLSLFIIYLSIYLSIYLSIYLSIYLSESVYYLPIYPSLFAIYLSIYLSIYLSIYLSKPFHYLSIYLSIYLSIYLSIYLSAFHDHIFFNLSSTRGFLSILFLITEQSNLSTTPQSVHVALCRLVTKSVSSLSIYLSIYLSIYLSIYLSIYLIIIYLSVYIQTNYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E9P8</accession>
    <name>A0A812E9P8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_70355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005149">
        <property type="protein sequence ID" value="CAE1320086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E9P8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1320086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="186" mass="21811" checksum="CB2475583285FD3D" modified="2021-09-29" version="1">MGHRPKREENNDDDLADFTFFFSLLYHVTSTFSSPFFIMSQVPFLSPFFIMSQVPFLSPFFIMSQVPFLSPFFIMSLVPFLYHVTITYFFSLLYHVTSTFSFSLLYHINSTFSFSLLYHVTSTFSFSLLYHVTSTFSFSLLYHVTSTFFFSLLYHVTSTFSFSLLYHGTSMFYSPFFINLQGLSKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EB76</accession>
    <name>A0A812EB76_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_70423</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005157">
        <property type="protein sequence ID" value="CAE1320176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EB76"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="413"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="446"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="492"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="524"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="549"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="580"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="622"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="651"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="683"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1320176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="725" mass="80170" checksum="7DF9708B8C6817F8" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EDB8</accession>
    <name>A0A812EDB8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_70499</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005163">
        <property type="protein sequence ID" value="CAE1320238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EDB8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="315"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="365"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="408"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="438"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1320238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="460" mass="55810" checksum="F235BD4DFD439E46" modified="2021-09-29" version="1">MSFFLSHTISYSITFSPFDRQCLSFNFFLFFFPHFLSTFLLLIMTLSLFVIFLSFSYDFLSFCCCRFSYYPFSAFLLIIPTLVLHLVFPLNTLLFLSFFLSFFLFRSLKSFTRPVTFPFFLSFFLSFFLSFFLSFFLHFLFHFYFFISFPKRHKLSLRLIQLFFFFFLSFLFFLFPLFEFIFVQFLSFFLSFSFFLSFFFIPFFEIITFFPQETSSLSLLLYSFTFVFFLSFFSVFAVHISKYFFLFIASIVYYLIYFLFHSSVYSSLPLSFLFIIFHVSFFSILSFFDLFNFFLPSFEIFFPSFCFKYRPPLSFFLSFFFFFLSFTLSLTVLIFQIYFFLSIYLSVIVLMDKMGSRGKSEQSIYLFRTLLLLPFSFVSLLVFSHFFFNFCFYSPYFLRFIPFVFHSYAPFSVLSCFTSFFFFSIFSFLTLSFLHSHFLSSVSLFFLFLPFVIFSFFFFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EF45</accession>
    <name>A0A812EF45_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SPHA_71174</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Farmed</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB5 displays a chymotrypsin-like activity.</text>
    </comment>
    <comment type="function">
        <text evidence="12">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the proteasome complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is a barrel-shaped complex made of 28 subunits that are arranged in four stacked rings. The two outer rings are each formed by seven alpha subunits, and the two inner rings are formed by seven beta subunits. The proteolytic activity is exerted by three beta-subunits PSMB5, PSMB6 and PSMB7. Directly interacts with POMP. Interacts with ABCB1 and TAP1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the peptidase T1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005210">
        <property type="protein sequence ID" value="CAE1321013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EF45"/>
    <dbReference type="OrthoDB" id="37597at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005839">
        <property type="term" value="C:proteasome core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03761">
        <property type="entry name" value="proteasome_beta_type_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000030">
        <property type="entry name" value="Proteasome subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF3">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="7 12" id="KW-0647">Proteasome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0888">Threonine protease</keyword>
    <keyword evidence="8" id="KW-0865">Zymogen</keyword>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR600243-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAE1321013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="275" mass="30730" checksum="6F9223915EC1D2AF" modified="2021-09-29" version="1">MALSEVCGFQQNFLKGEFQALDCPFSSHTLANDAFFAAEHLTLPKNFDPVENLKQFTDERSPVRIRFNHGTTTLAFKFQHGVIVAVDSRATAGPYIASQTVKKVIEINPYLLGTMAGGAADCSYWERVLARQCRIYELRNKERISVAAASKLLANILYNYKGMGLSLGTMICGWDKRGPGLYYVDSNGERISNDVFSVGSGSTHAYGVLDTGYRYDLTDEEAYDLAKRSIYHATHRDAFSGGVVNLYHMKETGWVKVSQTDVLDLHYQYQGEKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EGI8</accession>
    <name>A0A812EGI8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_73289</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005370">
        <property type="protein sequence ID" value="CAE1323338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EGI8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="298"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="390"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="418"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="454"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="490"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="519"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1323338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="567" mass="68722" checksum="35BA305E4DDF65DC" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EGZ3</accession>
    <name>A0A812EGZ3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_73487</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005380">
        <property type="protein sequence ID" value="CAE1323654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EGZ3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1323654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="273" mass="33099" checksum="FB0359A0CFC5741F" modified="2021-09-29" version="1">MKIFFSLSLSLSLNSIFLDPVFSTLTFFEEFRLHFRYIPFEFSNLLAFPTSFLSFFLSFFLSFYFLYSDFLHFSTISFSTLFTFFFFSSFFFKFFFVFFFLFFIFLLILLFLLLPLCHFLFFSLLFFFFLFVFFFLLCFLFLFVSFFLHFFLLFPLSFLIPQLLLFNISASFFLSLFFIHLIILLHYDFKNLFYNFFSSFSYTFLKRKGHTFSYSYSQKNLFTSFFLIFISPSDISLFFFDFLSFSLHSSTFLSSKSNLHLAELSLSLSLFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EIA9</accession>
    <name>A0A812EIA9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_74943</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005443">
        <property type="protein sequence ID" value="CAE1325304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EIA9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1325304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="192" mass="22445" checksum="38060C493FE8B03C" modified="2021-09-29" version="1">MSVRVSLFLCACAHVCVCMSFFAHAPDYSAFFLPADIFLSAFFFLSDIFSFIFLILFVIYSSDSFLSFFLSFFSFLFISSDTFFISFLLLVLSFSLSLSLSLSLSFLFSFFSFPGVSLFTACHNSIFVYYFLSFCLSFFLFLIISSFFFDLFIYLFFQQFLLSIYSILSFFFPDISYLFVFFVLFVTYLIYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EJ97</accession>
    <name>A0A812EJ97_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_75493</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005460">
        <property type="protein sequence ID" value="CAE1325908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EJ97"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1325908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="306" mass="34431" checksum="C6630792E0BABDA5" modified="2021-09-29" version="1">MPLPTFFSSLSFFLSLSLSFSALLFYIPRPLTTTHSPSLFQILSLFFSAYLFYISRPLSTTHSPLLFHTFSLTLSLSLLYFSPFFNHSFSVPLSNSLSLFLCHSLLYFSPPLNHSFPVPLSIYLSLSLFAFLFYIFHPPPTFHSTLHFHPLSPPFASIFLALSQPLILRSSFTHILSLSPPFTSIFLALSQPLILRSSFTHTHTLSLLLCFSSLYFAPSPNLSFSASLSPSSHFSFIFLALSQPLILPPSFTHSLILSNFLSIVLFIYSLIFILSLTYSLSISFSLSLFAIEFFDFPPPSFSLLCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EKT6</accession>
    <name>A0A812EKT6_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SPHA_72682</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005338">
        <property type="protein sequence ID" value="CAE1322759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EKT6"/>
    <dbReference type="OrthoDB" id="5990578at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009301">
        <property type="term" value="P:snRNA transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021281">
        <property type="entry name" value="SNAPC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15132">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15132:SF1">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11035">
        <property type="entry name" value="SNAPC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="586"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="624"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="657"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="3">
        <location>
            <begin position="21"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="376"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAE1322759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="687" mass="76669" checksum="B99D1D05E78AB4F0" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EL39</accession>
    <name>A0A812EL39_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_77715</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005521">
        <property type="protein sequence ID" value="CAE1328133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EL39"/>
    <dbReference type="OrthoDB" id="8040188at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1328133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="230" mass="25970" checksum="39F9D2951AA2A1CE" modified="2021-09-29" version="1">MAAVRLSQSPQARHICLNGDIKSLAAVHGITCPSSSFWSFLAFNYNPSINLTIHDNLNVESMTCICQFCNLHKWAGDPACLCCSSIKVRLPLLHEPPTLLRGLIASSDPDSNHFLKTIRQYNNSFQMTSFGAQVVEKWVGCPLSKYRGRYTTALGLCCLRRPLHLNSFNCTLLQTTTYRPKPRLVFCRHQKKFLAGTSYYYFRPCFTRLTATFAVSNMLCKMLPFLPSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EMK8</accession>
    <name>A0A812EMK8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_77364</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005516">
        <property type="protein sequence ID" value="CAE1327931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EMK8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1327931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="281" mass="34236" checksum="CCD334AE6A82A8B6" modified="2021-09-29" version="1">MLFLPSFFLSSLHFSFHTSFIVLFYTPFAFNLSFFFVSFLFFLFFHILYPSALTVLISFLFFFHSCLFPSLSVFLFLFSSFPLCYFSYSFYIFNYHCFFSFSYFSSLLQYLLLILFFFSFSLYHLYSSIILILFFISLMIFLPYLLLFHYIFFHSNAFLSVFILFVSSYHLPFTNIPFTFIFLRLSFFLLLFSFFFFFLFLPDLLHSFYFIYFSFFPILLFHSFSFFLFCDISLPVFILFILFRPLIFFITSLLSFSLELPILIFHVTFYHLHFAFCLFIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EP86</accession>
    <name>A0A812EP86_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_76309</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005487">
        <property type="protein sequence ID" value="CAE1326756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EP86"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="323"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1326756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="388" mass="45930" checksum="2525A8C30A15621E" modified="2021-09-29" version="1">MTICSYLSIYLSIYLSIYLSIYLSIIISIYISIYISFHHNQFFIYLSIYLSIYLSIYLSIYHNLLISITVIINIYLSIYLAISISIYISFHHNQFSIYLSIYLSIYLSIYHNQLIIYLSIYLSIYLSIYLSIYLSQSVNIYLSINHNQSSIYLSIYLSIYLSIYLSIYHNQLIIYLSIYLSIYLSIYLFQSSPLFPYTFFFLFYLIDTTLSFKRCLNITKTKLSFCHSESNAYYSFYLSIYLSIYLSIYLYNTIYLREGVETLSPYLSNYLSQLYAHIYLSIYLSIYLSIYDGMLKHSDLTYLSIYLSIYLSIYEGMLKHSDLTYLSIYLSIYLSIYLSISGLTLSGLRHYLSIYLSIYLSVDVEIFSVRLSLSVYLSIYESKRKGWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EQY9</accession>
    <name>A0A812EQY9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_77315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005514">
        <property type="protein sequence ID" value="CAE1327905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EQY9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1327905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="236" mass="27381" checksum="B99C09F8971F3125" modified="2021-09-29" version="1">MCLTSFFLCAPTLTNAPIPKTSSCIHIDVIDVILNLPICLSIYLSIYFTLAIPVNLSQFIYLSIYLSIYLSIYLTLTISLIYLSLSIYLSIYLSIYLSYANYLINLSQFIYLSIYLSIYLSIYLSYANYLNNFSRFFHIVIFHFGFILSFSFFLSFFLSFFLSFFLSFTLILIILPLSFFISRHTHTYICVFTRVYKSHSILSLLPYFLSIYDLAAVFVQPVGVCLSIYLSIYLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ES90</accession>
    <name>A0A812ES90_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GPR135</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_78341</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005535">
        <property type="protein sequence ID" value="CAE1328702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ES90"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="325"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1328702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="362" mass="44009" checksum="6AEB2D245F10F601" modified="2021-09-29" version="1">MVNLILDSNPSRPYINLSLFFFLFFFLFGNLISYRYLPWPLIFLSFFFLLFYIHIRRLFSFKIFILSPLPSSSLITSIHSLFFPLQLFLFTIFFHSFFSLYSCLLILTSFLPFFFPSFLSNPYLLSFFVSLLSLLSFFLSFFLSFFTSYYYFFFFHCFFLFSFSFSPFIAESQIFSFFFEILTFTLSFFLSFFLSFFSFFYFEDFHNVLSFHLIRIFPPFVCFCHAFSSNQHFLFLSFFLYLFIYFISRISITCYLLPFHLIRVFFSFFCFCHALYFFLSFFLFSFLSFFLSFFLSFFLSLFYFVDFHNVLSFAFSSHSCFLSFFFVSVMLCISFFLSFLSFFLSFFLFSFLSLFILFRGFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ET52</accession>
    <name>A0A812ET52_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_79389</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005566">
        <property type="protein sequence ID" value="CAE1330063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ET52"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1330063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="243" mass="29507" checksum="309B169A328D62D0" modified="2021-09-29" version="1">MLFFLFFLSFFLSFFLACLISFLSFFISFFHSFFLSFIRVLNRVSFFQELKLMPFFLSFFLSFFLSFLLACFLSFLHFFFSFFLSFFLSFECLTACLSFKNLNSCFSFFSFFLSFFLSFLLDFLSFFLHFFFSLFLSFFHSLNSCLSFFLSFFLSFFISFFLSFLVAFFPFFLSSFLFFIISFFLSFECLTACLSFKSLNSCFSFFLFSFFLFSFFLSFFLSFLLDFLSFFLHFFFSFFLSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EVP8</accession>
    <name>A0A812EVP8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_80234</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005595">
        <property type="protein sequence ID" value="CAE1330979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EVP8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1330979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="240" mass="29237" checksum="5EB9EF88DFAEAA98" modified="2021-09-29" version="1">MIIAIESRSFFFFSFFLSFFHLSILSFLISFVFLLFFLDDERLFLLLFVIFTFIFLFLFFLLCSPFFLITFWMTFLSFVLIFLSFSLLLFSFVRLPFFFLSFFLIICFDYELFFLPYSFLLVLYSFFLSFIGAFFFLSYYAFFHLNLFISTFHFLFFLFRLLFVPLFSSIFFFDLSPFLFISPFLLLFSFFVVFFLHSFFYYLSLPSVFFLSFLRSLGHLVHAPKIHRKSQLLDAFNTLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EWI3</accession>
    <name>A0A812EWI3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_79984</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005586">
        <property type="protein sequence ID" value="CAE1330712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EWI3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1330712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="263" mass="30897" checksum="E282CFF77D205446" modified="2021-09-29" version="1">MPLGLLSNFVHQPPPKIDYLSSFHLLQIFCQDSDIYFLSRFLFRHNDFQIWSTLPASLPLLFLPRLYLFISTIPTSIISHLTIDFPSSCAYHSSPSAVISFFQSLLHVVHLLRLLPLASSYLPLLLTTCSICHRFSFLSSFLSCFLSSFHSFFLSSFLSSFIYLPLMLSSFSLLSLSLSLSIYLSIYLSIYLSLYSNLQNNKLNKYFYRFTFSHSLSFLFLLLFLYYFHSFHFDFFLRLFKFCFFLRFLSFLPFFSFLSNISF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EYS3</accession>
    <name>A0A812EYS3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_79613</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005573">
        <property type="protein sequence ID" value="CAE1330273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EYS3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1330273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="218" mass="23977" checksum="395E6143348013D2" modified="2021-09-29" version="1">MNRKLINAIPSASALTSGSNISIITIFTSLGYFPSLSFFLSFFLSFSLSLSHLVTLSFALSHFLSLSFSLPRSLSISFILSLSYSLSHLFLSLYHSRSLSFILSYSLSLTLSLSLLYSLSLLLSLSITHFLFHSHYRCCFLSLFLFLSLSFSPPLILIHSLSLALSWSLSLSFTVSLSIALALTLFISIAHSISHSLSLCFLLLSVSLTLSLSHSHSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812F063</accession>
    <name>A0A812F063_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_80956</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005615">
        <property type="protein sequence ID" value="CAE1331831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812F063"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1331831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="207" mass="25102" checksum="BE39043761B7E54B" modified="2021-09-29" version="1">MSSSLLLPFFLFFFLSFFLSLHLSFHPFFLSLSIFLSFFFLSSFFPSFFPSFLPSCLYFLFIFFSVCIFLRFLISGTVRSLILHSVIFFLSFFFSSFFLSFFLSLFIYFLTVFIIYFFPSILFLYYLWYSSVFFVPSFFLSLFYFSFLSLFFHFFFSFFTIRISFAFSLQSEVLFCIPLFFLLHLFSFFIFLSVFLYCLHHFSHVLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AJ20</accession>
    <name>A0A812AJ20_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mon2/Sec7/BIG1-like dimerisation and cyclophilin-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_319</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000004">
        <property type="protein sequence ID" value="CAE1139026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AJ20"/>
    <dbReference type="OrthoDB" id="10002886at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032629">
        <property type="entry name" value="DCB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16213">
        <property type="entry name" value="DCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Mon2/Sec7/BIG1-like dimerisation and cyclophilin-binding" evidence="2">
        <location>
            <begin position="5"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1139026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="222" mass="25848" checksum="F3BC36DBDD22839D" modified="2021-09-29" version="1">MERVLKDLANEASIPKFYTIKKACLDALDFLLSPNAKEVPAYQLRNRCLEPFQMALETRTKRLSNMAIKGIEMILQDNQFQSTMESESEEKRLPFQILRTIYTSPNLQEDAQIEIIKLLLNMSLSSAWCVNSKVIAEISQNVEKFLSSFLPFFLSSFLPFFLSSFPSFLPFLPFYLSFLSTFPSFLPFLPFYLSFLSTFPSFLPFFLSFLPSFQLFFFFYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AQV9</accession>
    <name>A0A812AQV9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_2841</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000083">
        <property type="protein sequence ID" value="CAE1150108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AQV9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1150108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="338" mass="39860" checksum="61C293C2F8648556" modified="2021-09-29" version="1">MCDSLPVGTKLFQCSYISIYLSIDLNVCLFVSFFLSLPYLYLSIYLISILFNFFLSFHPSFHSFSLFNLLISIYLSIYLSIYLSIYLSIYLSLSLSPFFLSFFLYFIHIYLSIYLSIYLSIYLSIYLSIARRGGATNFYLSTYLFHSVHFYLSRTVHIYLSIYLSIYLSIYLKLFKSIYLSIYLSIYLSIYLNLFKSIYLKLFKSIYLKLFKSIYLSIYLSRSAPICLPVYLKKKIDIERARMCSRQTIKETVIKKETKQNFCRTKQAMAESRDETEGKETLSLCFCDTFRLLSSLFLQTLVRKAKFSIDHFPRDRFGKISGLSTFPLNFVVSLLFIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ARH9</accession>
    <name>A0A812ARH9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_3755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000113">
        <property type="protein sequence ID" value="CAE1153198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ARH9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1153198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="154" mass="17882" checksum="B43274BE12E37663" modified="2021-09-29" version="1">MSKQQASAEDQSNNRLEHCIENIRDEDNNLENDCNESNIYFVLLAVICICLIIIYLSIYLSIYLSQSHHIYLSIYLSIYLSIYLSIYLSLLISIYLSIYLSIYLSLSLSRSLSLFLSLDIYSFQYLSIYLSIYLSIYLSIYLSLSLSLSFSLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AS12</accession>
    <name>A0A812AS12_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_4414</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000139">
        <property type="protein sequence ID" value="CAE1155186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AS12"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1155186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="310" mass="37633" checksum="83BCD0C2E34407ED" modified="2021-09-29" version="1">MLFLFQHINHSCLLAFFFLIFAAPPFFFVFSLFFPSFCLFVCLFVSFFLYLLIYFFRSFFRSFVRSFFLSFFLSFVRSFFLSFVLSYLFCIATVPLFFFSLPSVLLALFFSFSFLVYLAFPFSLSFLFIWPVYLNFLHSFLNILHRLHFLFLIISSSLSFLNFSDTFAFSFFLISFFLFSFFFSFSFTSPSPSFSFLFFSLLFNWHFHRHAILSFFPSYLFCIDILHYIFFNIFFFIFSFIFLSFHTFLFLFSFIFLFSALSYFSFFVLLTFINVLSFFVCLFLSFFLFFFLSFFLESHRNVKILKEEYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AS73</accession>
    <name>A0A812AS73_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_4257</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000132">
        <property type="protein sequence ID" value="CAE1154569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AS73"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1154569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="206" mass="25518" checksum="D2262292BE908353" modified="2021-09-29" version="1">MPYFHILSFISYIFVTYFYKQQFLSHTPLSFTLFLLFFFLITLLSLFLSFSHFLIIPNYPSFFLLKFFFLSFFSSFLLKFYLFMFSFYNPLIFHLSFLMTLLKTNFFLSFFLSFHFSVKTYLTYLFMFSFYKYCNLSFFFLFNCLFFISFFFLSFFQFFVKEKPINFSFIIPNLFFSFLITLLSFFLLFLSFTFLLRLTYLCFFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ASC6</accession>
    <name>A0A812ASC6_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SPHA_4308</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000135">
        <property type="protein sequence ID" value="CAE1154789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ASC6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
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        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="62"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="188"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="347"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="86"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAE1154789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="372" mass="44823" checksum="829312FFCD477305" modified="2021-09-29" version="1">MFSLFAFIYYVHLACPPLSLSLFLSFLLPNFFFFIRSFFFILVISLTYSFQSFPFQCLFHYLSCAIFFSFLFLCLVFFFVSFTLIFNFIFFVTFISFSFHFTLFFLILITFCILSVLVSLVYLLQFYSFSLFFFLSFVLYFLPSVSTYSLFFVFFHSAFFLFCFLSFFVCFFLCISLYVYITYNSFTITVFFLSFFLSFFLSFFLSFILSFFFLHLLLQTVYNVLRFTHCNLSVFLSFSFSLSLYFILFSIFFLSFFLLFLRIYSVFLSLFFPTFLPLLFLSFLIFLSFFFVSLSLFLSFFLSFLHFFLPCIYTFSNSPFSFFLSFFLSFFSYLSLSLSSISFFSLHIWLCTYLFIYLSIYLSIYLSIYLCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AVI3</accession>
    <name>A0A812AVI3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_4983</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000165">
        <property type="protein sequence ID" value="CAE1156920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AVI3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1156920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="223" mass="27347" checksum="AB5260CD191D8CF8" modified="2021-09-29" version="1">MAAFWTENILSFSFFLHFSHFHIFLTSLFSFSQIHSFFFFFFFILIIFRLSLYLSLLFRSFIFLFWFFFLVFIYSYFRSLCFKLHDFLPFFILSFFPSFLYLSFCLLLLSFLHPFYFSPFFFFPLSFYLIFLFSYFFQLCLFFLLFLFLFLHFFLLSRPFFLQGKMRRSKPHLESRLDKEKFLSSFRHFSSTTSLFFFIPPPVVSFTNVSPITHNTSLQATTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AX74</accession>
    <name>A0A812AX74_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_7441</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000238">
        <property type="protein sequence ID" value="CAE1162797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AX74"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="209"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="329"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="357"/>
            <end position="380"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="386"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="421"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="464"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="506"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="537"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="562"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="599"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1162797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="634" mass="74515" checksum="123303937630C18D" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AXN6</accession>
    <name>A0A812AXN6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_7671</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000247">
        <property type="protein sequence ID" value="CAE1163419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AXN6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1163419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="258" mass="31381" checksum="CF7A8BF80230165B" modified="2021-09-29" version="1">MSVYIFHSIYLSIYLSIYLSIYLSHSIHIYIYIYVYIFYSLIHSYLSIYLSIYLSIYLDVFFLNYILALSFSFFLSFFLSFFLSFFLYFFIYFCIQYIFLSFFFLSFFLSFFSVFPFFSPSFTCFVRECVCICVYVCHSFHLFPLSLSPFRLAPTFFLSSFFFSFFLFSFFLSYHINISFSIYLFSFFLSVYHISISFSLSLFFLFFLSFHISSRFLFLVLFFLSLFCPFFLFVCFFLFPSTFFPFYLSSLLSFYILI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AZF3</accession>
    <name>A0A812AZF3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_7824</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000254">
        <property type="protein sequence ID" value="CAE1163933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AZF3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1163933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="217" mass="25350" checksum="71D2B4E73C8751B3" modified="2021-09-29" version="1">MYALRNESIYLSIYLSIYLSIYLIYFSLFIICLSQFKPKSISIYIYLSIYLSIYLSLSYLSIYLSIYLSIYLSIYLCTYLSFYKSISISSYISIYLSILGFCSYLSIYLSIYLSIYLSILGFCSYLSIYLSIYLRPFISIYLYIYFNQFICMYISISVSPYLSISIENVKICSHMRTRAHISLSFFHSLSLSLPLSLSLSLSLSLCINAWRLKTVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AZV8</accession>
    <name>A0A812AZV8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_7416</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000238">
        <property type="protein sequence ID" value="CAE1162794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AZV8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1162794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="249" mass="29904" checksum="E2449E89C71706B9" modified="2021-09-29" version="1">MFNVPVSTYKLANIHSQEHAHLTRSFLLFIKTIYSFSLFSFLFSSLYIFFFLSFSLLFIFLLFFLCNVIVLLFLRLFFLLLFSLRVSTCIYFFLSFFFFLYFFLSFFLSFFLSFYLSSSLFLSFSPTVHSSILSFFLSFPQTDLSFFLFLQQSIVSFFLSLFSFFFYLIPFFLSFFSSNRSFFLPFPPTVHPFFLSFFLSFFLSFFLFLKHFFLNPVYTSTNISHTHKNTLYLSIYLSIYLSIYLSIYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B531</accession>
    <name>A0A812B531_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_11043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000363">
        <property type="protein sequence ID" value="CAE1170350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B531"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1170350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="166" mass="19665" checksum="D8121740BAC60B30" modified="2021-09-29" version="1">MSEYEKAYQIGECEHTDTQKQADTRQRPGASIYLSIYLSIYLSIYLSIYKFSVCSHLSIYLSIYLCLSQFIFHYHSIPLFYLSIYLSIHLSIYLSIYLSINSLCVHIYLSIYLSIYLSIYLSIYLSKILRLCLSQFIFHYHSIPLFYLSIYLSIYLSIYLSIYLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B671</accession>
    <name>A0A812B671_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">SPHA_9965</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">Farmed</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CAHIKZ030000319">
        <property type="protein sequence ID" value="CAE1168284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B671"/>
    <dbReference type="OrthoDB" id="6285334at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042995">
        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030832">
        <property type="term" value="P:regulation of actin filament length"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.240.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052409">
        <property type="entry name" value="Myosin-III_kinase_activity"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46256">
        <property type="entry name" value="AGAP011099-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46256:SF3">
        <property type="entry name" value="MYOSIN MOTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0966">Cell projection</keyword>
    <keyword evidence="18" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0505">Motor protein</keyword>
    <keyword evidence="11 17" id="KW-0518">Myosin</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6 21" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Myosin motor" evidence="20">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="17">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="193"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="349"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="430"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="306"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CAE1168284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="632" mass="72935" checksum="1AD75B6F850E3C86" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B8W0</accession>
    <name>A0A812B8W0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_13065</name>
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    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
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    <reference evidence="2" key="1">
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            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000435">
        <property type="protein sequence ID" value="CAE1174272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B8W0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    </feature>
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            <end position="128"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1174272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="160" mass="19199" checksum="6EFDEB49CB971D90" modified="2021-09-29" version="1">MLLSMSLDRVSSCFSFFLSPFSFLSFFLSFFLSFFQFFLLDVSSFLLFLLSIFSFFLSFFLSFFLSFFLSFFLFIPRFLVLLLFHSFFFLSFFLFLFLLDFSSPFFTLSFCLFLSFESYISMFLHYLFHNATPSYLAASFNRIFCCSLLVFILFLFAFYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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    <name>A0A812B9G4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_13981</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="CAE1176094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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    </feature>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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    </feature>
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        <location>
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    <evidence type="ECO:0000256" key="1">
        <source>
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        <source>
            <dbReference type="EMBL" id="CAE1176094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1461" mass="172389" checksum="BF63BB1BF9B2AD7A" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BAV2</accession>
    <name>A0A812BAV2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SPHA_14803</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
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        <lineage>
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            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Farmed</strain>
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    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="417697at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052735">
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22809:SF11">
        <property type="entry name" value="TRNA N(3)-METHYLCYTIDINE METHYLTRANSFERASE METTL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0808">Transferase</keyword>
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    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
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        </location>
    </feature>
    <feature type="chain" id="PRO_5032768689" evidence="5">
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        </location>
    </feature>
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        <source>
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        <source>
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        <source>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BD20</accession>
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    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000449">
        <property type="protein sequence ID" value="CAE1175055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BD20"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="255"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="303"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="342"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="376"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="417"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="457"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="489"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="517"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="545"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="589"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="613"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1175055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="646" mass="74265" checksum="D88CD63406A9FAFA" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BDZ5</accession>
    <name>A0A812BDZ5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_18261</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000657">
        <property type="protein sequence ID" value="CAE1231642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BDZ5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1231642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="262" mass="30356" checksum="8A01D04DBFA779DC" modified="2021-09-29" version="1">MFLKKDISLYLSREKQNFLVLSLGRMFLQDISLASPEKNRICLVLSLGRMFLQDISLVSKKTESYYLSEELQYISSPEKTELSRIISRKNVLARYLISLSELSREIISRKNCLVLSLGRMFLQDISLVSPEKTELSRIISRKNVLARYLISLSRENRIVCIISRKNVLARYLSLGKRIFSYYLSEECLQDISLVSPEKTELSRIISRKNVLARYLISLSRKQNCLVLSLGRMFLQDISLASPEKNRIVSYYLSEECSCKISH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BJA7</accession>
    <name>A0A812BJA7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_17694</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000633">
        <property type="protein sequence ID" value="CAE1230403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BJA7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1230403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="277" mass="33618" checksum="6036D314BC3E7124" modified="2021-09-29" version="1">MYSFLFYSNLLITFSLLFPFLTLAIFLIPFHSQLYTFFLYFLLFYCFLFFIFYFLFSLFSFSFCTFLSFFSLSFLTPILFTFYSFNSLYSPLSFHLFSESFLSSSTNRFFSLFLLSFSSWFTLLCCTLLFIHFLYFFLSALINFFPLFSHTLLQYFLFAFHFFFTLFLCIHSSLLLLFATFFFSFFCSCFPFLLKHSSLCFLLFDILLFFSFFMPPLFIFLVHLFFSLSYSLIFPFLYIHFYYFVFLSPPWIFSHCLYLSQISLYTVIFFLLICPLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BJL7</accession>
    <name>A0A812BJL7_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_21598</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000792">
        <property type="protein sequence ID" value="CAE1238948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BJL7"/>
    <dbReference type="OrthoDB" id="10070352at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="197"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="229"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1238948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="320" mass="36328" checksum="EA3A4EC826CC08E6" modified="2021-09-29" version="1">MSTGSGGQPSLSNDVIVGGYISSFSDGRASISSVGRRALFVPVFPAFTVTGVGGSVTEAIRLSNDNAGVPRRAQRGRKPRVDQKGKSSLDLRIRTAKAWPIDPFRAESSFPPRGVRKVTTGITGLWRPSVFSDPESRPVPSRYYEMRCLCRCAVHDLRVNPFSAADARRLRFFLYLFPRVVRYGSPLAALLRRYRAFLFFSLSFSFSLSVFLSFSLFLSFFLFRSFSLFRFLFLTLSFFLALSFFLFSLFLLFSLSLFLSLFLFRSFSHFRFLFLSPFLSLSLSLSLSFFLSFFLSFFRFLSRSFFLSLSFSLSLSLCIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BKJ7</accession>
    <name>A0A812BKJ7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_18358</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000664">
        <property type="protein sequence ID" value="CAE1232140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BKJ7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1232140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="199" mass="23327" checksum="EEDF765EE612F883" modified="2021-09-29" version="1">MNIYLSIYLSIYLSIYLSIYLSIYMSVCLFRSFSLSVFFPLVLSFFLSFFLSFFLSFFLSFFPSSSSSSSSSFWQLCFCSEINFFFFSFSFTSSDAFFFFFVIHCLFFFSLAFLVVCSLFLTNIILFLHSYDAFLFNFFFLSSPRFIAFFPFRPLLSFASPFSTTSPPPLLILPPCFPCIYLFLTKPFSSLHYLFSFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BKX9</accession>
    <name>A0A812BKX9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_22307</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000824">
        <property type="protein sequence ID" value="CAE1240438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BKX9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1240438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="207" mass="25547" checksum="0636D85AE9354A82" modified="2021-09-29" version="1">MHLIYLSIYLSIYLSIYLSMGIQCHKMNIGIHNTRKNATEKKTYTFFLSFFLSFLFISYSFLLLPLFLYFSNILFNFTYSFFRSLFLILFTFFLFFFLSFFLFLSFFLSLFLSFFLSFFTFQIFYLFYLLFFILSFLFIAYSFLIHSLFLYFLIFYLILPFILPYCFIFLPSFFSFFLFFLYFQIFHLLLLILFLVGSLVFYFFTFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BMM4</accession>
    <name>A0A812BMM4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_19513</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000707">
        <property type="protein sequence ID" value="CAE1234715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BMM4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1234715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="251" mass="30686" checksum="E7A344DCD6123CC8" modified="2021-09-29" version="1">MRDRSSGQSSFGITNLKIRIIGLIFSSSTPFFFLSFLVSFFLSFLLSFFPSFFLSFFTFFLSFFLYFFRSFFLSFFFPSLCLSLFIYFFIFLSFLFPPFFLSLFICLSFLPSFFPFSFPSFCFSLFRSFFLSFLLSFFFPFFLSLFLSVFLYFFLFFFLFSSYFLSFCFHSFFFFFFLPFFMSFFLSFLFSLSFFLSLFIFSSLLSFFLSFFLSFFFISIFLSLFIYLFISFFLFFFLSFFLFDFFFLFLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BQX8</accession>
    <name>A0A812BQX8_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Solute carrier family 35 member F5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SPHA_22338</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC35F solute transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000824">
        <property type="protein sequence ID" value="CAE1240410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BQX8"/>
    <dbReference type="OrthoDB" id="10041630at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23051:SF0">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23051">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35, MEMBER F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="213"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="326"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="371"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="407"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="437"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="467"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="496"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="527"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="559"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="584"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="621"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="645"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAE1240410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="663" mass="77802" checksum="7A457C83CF4CA2FA" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BRB5</accession>
    <name>A0A812BRB5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_21357</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000783">
        <property type="protein sequence ID" value="CAE1238540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BRB5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1238540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="359" mass="42314" checksum="AC645CB11131DCA4" modified="2021-09-29" version="1">MKFHFKYLSINRSISLPLSISFFLSLSLSLSLSLSIYLSISQLLYYIILYIYLSIYLSIYLSIYLSIYIGLFVSLFYFVFSIYLSIYLGLFVSIYLYINCFYLSIYLSIYIYIYIYIYIYISIYLGLFVSIYLSIYLSISLSLSLSLSLSIYLSIYISQFVHLYFLFLSIYLSIYLSQSFRIYFVFLSIYLSIYLSQFYLSHFDVSRWPAIIYLSIYVGLFVSIYFVYTLSLSHTLSIYLSIYLSLSLYIYIYIYIYIYIYISRSIRIYLSIYLSIYLSISRMALGEYCRHPFFFFLLRLLLFLLLLLLLLFFFFSSSSFPPPHSSSSLPPPPVLLLSLLLVLLHGDVSLQNVGDQGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BTJ0</accession>
    <name>A0A812BTJ0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TMTC</fullName>
            <ecNumber evidence="2">2.4.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_25020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CAHIKZ030000946">
        <property type="protein sequence ID" value="CAE1246198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BTJ0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1246198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="207" mass="25066" checksum="324F8E22BB6E2F8B" modified="2021-09-29" version="1">MKKDGKSGPPKMQNMTIRESYDNGKMNPAVIIVFRAPTKNLSFFFPFSSFLSISISFFLLYFFLFLSFIFSFVIFLHSFFFPTILFFFLLFVFVCFFLSFFNRSYFFSSLFSIFLPFLFLLFIHLSSFLSFFLSFFLSFFLYILHIYLFYFFFILFSLFQSAFLCFLYFFFISFFMLLLYHFFLLLTFFFLPSRIFSVLICPVLANQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BTZ3</accession>
    <name>A0A812BTZ3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_22059</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000813">
        <property type="protein sequence ID" value="CAE1240015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BTZ3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1240015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="249" mass="30580" checksum="4A2DD7F65FF3760D" modified="2021-09-29" version="1">MFIFSFPSSISFLIIFIFSFYFFNIIFLFSLNFSISLELFHFLSSFSFALYFSTHSFLFMFHFCYPFFFFLLTFLFFLSLSFLPSSFTLFLFLFNFLLLIFHFLSSFFSSLLFHSPFVFHFYFSSLFFTFSIIFHLSSLSFSFFFVPLIHFHSLFIHPFFFLFTLHFALISFFLIHFSFSPSFFLYHFLFPFSFFHSSLFVFLSLYFFSLFSFLLFIFFLLFSFYFTFYFSSPFFLKSFFFLFITQNQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BW42</accession>
    <name>A0A812BW42_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_25178</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000953">
        <property type="protein sequence ID" value="CAE1246479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BW42"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="280"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="304"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1246479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="359" mass="41636" checksum="12537A6C086542D6" modified="2021-09-29" version="1">MYVCILAACSYLSIYLSIYLSIYLSIYLSIYLSIYLSLSVNCDLTLFISIYLSIYLSIYLSIYLSISVYTYLSIYLSIYLSIYLSIYLSIHFCILFIFISVCSYLSIYLSIYLSIYLSIYLSIYLFLLTAISLCSYLSIYLSIYLSIHFCILFIFISVCSYLSIYLSIYLSIYLSIYLSIYLSVNSDLTVHIYLSIYLSIYLSIYLSIYLSIYLIPALSPFSPENPYSPTLLPRELTLFLPALPRIHAFLSFLNIASLCTLSIYLSIYLFIYLSIYLSSLFIFSHLSIYLSIYLSIYLSQPIHIYLSISVCSYLSIYLSIYLSIYLSQSVHIYLSIYLSRQKCDALCENQIHLSSFLDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BWD5</accession>
    <name>A0A812BWD5_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Translation initiation factor IF-2, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SPHA_24787</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Farmed</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000931">
        <property type="protein sequence ID" value="CAE1245569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BWD5"/>
    <dbReference type="OrthoDB" id="361630at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01887">
        <property type="entry name" value="IF2_eIF5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03702">
        <property type="entry name" value="IF2_mtIF2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03692">
        <property type="entry name" value="mtIF2_IVc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000007">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000008">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10050:FF:000001">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000019">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="entry name" value="Translation initiation factor IF- 2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00100_B">
        <property type="entry name" value="IF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053905">
        <property type="entry name" value="EF-G-like_DII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044145">
        <property type="entry name" value="IF2_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000178">
        <property type="entry name" value="TF_IF2_bacterial-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00487">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381:SF20">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22042">
        <property type="entry name" value="EF-G_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="Initiation factor IF2/eIF5b, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01176">
        <property type="entry name" value="IF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="65"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="105"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
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            <begin position="653"/>
            <end position="823"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00007733"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAE1245569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1192" mass="134597" checksum="5EE28DE467E6F0B5" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BWT4</accession>
    <name>A0A812BWT4_ACAPH</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <location>
            <begin position="152"/>
            <end position="175"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="239"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAE1247225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="311" mass="36890" checksum="366DB90BFE633555" modified="2021-09-29" version="1">MRNKQLVLYKDKPRISLSLARSLSLSLSLPLNIFPLFSSFSFAFFFSFPFPFLLQISRFLFFFSFFFSFLFCFSSFFFLLVELILFLLPISFLFFPSSDSRFSFLFSFILFLLHSFLLTNCPSFLLSYILFTFFFFSFFRKKTLPTFSFKVFLFEIFSSYSLISFFFFFFFFFFFFSKAIVSSSSFLLLLVPPPCPHCFSLFFPFFSIIMLIIATLRSIYLSIYLSIYLSIYLSIYLLAELLITNCKKSECIDVSSSIYLSIYLSIYLSTYEKKLLAWNLRLSIYLSIYLSIYLSIYLSESLNACFSIFFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
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    </protein>
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        <name type="common">Pharaoh cuttlefish</name>
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        <dbReference type="NCBI Taxonomy" id="158019"/>
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            <strain evidence="2">Farmed</strain>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        </source>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C2U5</accession>
    <name>A0A812C2U5_ACAPH</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <organism evidence="2 3">
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                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    <dbReference type="Proteomes" id="UP000597762">
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            <begin position="468"/>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="498" mass="60551" checksum="D5447CCE2C126720" modified="2021-09-29" version="1">MTGSWGSEKSTFCFFLFFFLLLFLFLLFFLPPFFPASLFSFPFFLSFFLSFFLSFFPSSLSFFLSFFLSYAVSICLILFPFLSNSVSISLFLISFFLSFSFFFSFFLSFFLFSFFLSFFLSFFLFFFFFLSYAVSIFSICLILFPFLSNSVSISLFLISFFLSFFFLSFFLFFFLSFFLSFFFFLSFFLFSFFLSFFLSFFLSFFSFFLSFFLSFSFFLFYFFLSFFLFSFFLQISFPFLFFLFFLCPGLFLSFFLSFFLSFFLSYAVSIFSICLILFPFLSNSVSISLFLISFFLSFFLSFFLSFFLSSFLSFFLFSFFLSFFLSFFLSFFFLSFFLSYAVSICLILFPFLSNSVSISLFLISFFLSFFLSFFSFFLSSFLFLSFFSFFLFFFFLSFFFLSFFLSFFLSFLYILLFNFLTHFYFIFLFYFLSPFSFFLFFHFSFFLSFYLSFFLSFFLFLLFPSLHFSFFLFLCFFFFFFLWVGCRECLPIYKRSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C334</accession>
    <name>A0A812C334_ACAPH</name>
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        <submittedName>
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        </submittedName>
    </protein>
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    <organism evidence="3 4">
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001067">
        <property type="protein sequence ID" value="CAE1251250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C334"/>
    <dbReference type="OrthoDB" id="6115336at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
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    <dbReference type="Gene3D" id="2.40.50.90">
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    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
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        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16442">
        <property type="entry name" value="RING FINGER PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16442:SF1">
        <property type="entry name" value="RING FINGER PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <begin position="71"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="294"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1251250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="316" mass="35332" checksum="B3D8390B84FD4E4F" modified="2021-09-29" version="1">MDFSPQAFHCSLSTSDNEFVTEGWTGYLKVDAITEDGHYLVSLNQDTISASLPMYLQPEYVAGFTVEVIVCFTTDPTCLAKCSGDAEVWQRGIIQEEENGAIKIFFVDTGKEEKIPKSSVHRCPLSLFNQPVLAVSCFLVDIQPLNGSWSSAASELFKELTHNVSLELKAEVRSGGQHGIYLYKEDDDEAINDRFVDLGYALAESGSKLEVNRELEHSLLDPHRTKHMELSFHDISCCRESCYDDDFDCDTLSHNNSHGHILIEDSIKGPAVITNATRLKQEVTDENDKILLKEESIETSQKKSEEHCENLQKTGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C3K4</accession>
    <name>A0A812C3K4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_27702</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001082">
        <property type="protein sequence ID" value="CAE1251803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C3K4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1251803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="182" mass="20309" checksum="DB0C6E77F89A6DA8" modified="2021-09-29" version="1">MLSLNLFFPTFLYPPFPFHHSPLSILSISLLTDSFFSANFLSHSPFLSLLYSPSLSYSLLFSLSFTLPLSLLFSLSPLLSLSLSFSLSLLFSLSPFLSLLFSSTLSAFFSLSFSLPLSLLFSFSFTLPLSLLFSLSFTLPPSLIFSLSHFLSLLFSLSPFLSLSPFLFHSPFLLFDVVSLFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C598</accession>
    <name>A0A812C598_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_29886</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001200">
        <property type="protein sequence ID" value="CAE1255921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C598"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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            <end position="36"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1255921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="219" mass="26595" checksum="79B38B86060D6930" modified="2021-09-29" version="1">MFSMDLLIYFSYALFISIFTLLSFLSFLFFIFYIFVSLFRCILIYIFFFSISLRHFFYEFIYLITYTFSSTCRMSLSFVRHLYLSAHFIFLFPSFIFSFSFSLLSFFSFFLFLSTFLFSFSFAFSLLYFLPLSFFSFFLSPFFLSTLSLSLFSFSFLFFLSFLFSFSQPSSFFFLSLSPFFYFFFLSIYLSLSFLFLLNLSFVFLNMFSMRFLSFFSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C7U1</accession>
    <name>A0A812C7U1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_32828</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001369">
        <property type="protein sequence ID" value="CAE1261640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C7U1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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    <feature type="transmembrane region" description="Helical" evidence="1">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
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        </location>
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        </location>
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        </location>
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            <end position="1044"/>
        </location>
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        </location>
    </feature>
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        <location>
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            <end position="1104"/>
        </location>
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            <begin position="1110"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1141"/>
            <end position="1163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1261640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1173" mass="142592" checksum="8A7601F7A01F50B2" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C803</accession>
    <name>A0A812C803_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_31166</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001269">
        <property type="protein sequence ID" value="CAE1258316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
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            <begin position="181"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1258316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="211" mass="24673" checksum="4A62A06819DD5370" modified="2021-09-29" version="1">MSIFFAYFLSCNNSSLIFFSCFLSLPVFFLFLSSFPSFFLSFLSFFLFLSSVPSCLLSHPVIFPFLSAFHFYLLFFLVCFLCLSFFPFCLLSLSVFFSISVYYPFLSSLPFLSTFPFFLLFHFCLLSLSVFFSISVYFPFLSSFPFLSTFPFCLLYHSCLLSLSFFFSISVYFPFLSSFPFLSTFPFCLLYHSCLLLHPVFFPFLCPHNEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C9H6</accession>
    <name>A0A812C9H6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_29385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001169">
        <property type="protein sequence ID" value="CAE1255153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C9H6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134:SF22">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134">
        <property type="entry name" value="OS08G0543275 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1255153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="241" mass="27990" checksum="77BC245877B90BB2" modified="2021-09-29" version="1">MTILYSICQVSSNISKQICQHLSIYLSIYLSIYLSIYQIILSIYLSIYLSIYLSPLRHFLLLISIYLSIYLSIYLSHSGHIYLSISFRSHLSIYLSIYLSIYLSIYLSPVKCVYVCMYVCIYLSIYLSIYLSIYLSIYLSVCMYVCMHLSIYLSIYLSIYLSICLSQSGHMYVCMYVCMYLSKSVYLSIYLSIYLSIYLSIPFLTWVESYVNALSLSVSLSLSLSLSLSLSLSHRIERDFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CAP4</accession>
    <name>A0A812CAP4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">UBLE1B</fullName>
            <ecNumber evidence="10">6.2.1.45</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SPHA_31419</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Farmed</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="4">Protein modification.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.45" evidence="10"/>
    <dbReference type="EMBL" id="CAHIKZ030001290">
        <property type="protein sequence ID" value="CAE1258837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CAP4"/>
    <dbReference type="OrthoDB" id="10255449at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031510">
        <property type="term" value="C:SUMO activating enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019948">
        <property type="term" value="F:SUMO activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004839">
        <property type="term" value="F:ubiquitin activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.520:FF:000002">
        <property type="entry name" value="SUMO-activating enzyme subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.20:FF:000002">
        <property type="entry name" value="SUMO-activating enzyme subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.520">
        <property type="entry name" value="Ubiquitin activating enzymes (Uba3). Chain: B, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.20">
        <property type="entry name" value="Ubiquitin-like 2 activating enzyme e1b. Chain: B, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028077">
        <property type="entry name" value="UAE_UbL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023318">
        <property type="entry name" value="Ub_act_enz_dom_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033127">
        <property type="entry name" value="UBQ-activ_enz_E1_Cys_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF5">
        <property type="entry name" value="SUMO-ACTIVATING ENZYME SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14732">
        <property type="entry name" value="UAE_UbL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00865">
        <property type="entry name" value="UBIQUITIN_ACTIVAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="222"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="331"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="8">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="8">
        <location>
            <begin position="384"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin/SUMO-activating enzyme ubiquitin-like" evidence="9">
        <location>
            <begin position="728"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="830"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="841"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="858"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="894"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="5">
        <location>
            <position position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00043952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAE1258837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="917" mass="105353" checksum="29506463EC726471" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CBS4</accession>
    <name>A0A812CBS4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_31935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001324">
        <property type="protein sequence ID" value="CAE1259875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CBS4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="285"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="330"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1259875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="362" mass="42600" checksum="11BDF60624A92B77" modified="2021-09-29" version="1">MCQFSFCISSSSSSSSSSSSSSSSSSYFLVCSLIQSFIYCLNLFVAFANFTRQVAHSTVQNQTASSLIRKKPQKADLGFFFFLFFLDFYYIFFIGYFNHFFCCKFIRAQLQFPHSQTCFQVCYSSTLFFTFTTLLFVLAFLLISIFYSAFPSLKDFESYFTISLSLFSLLYLFSFSIFSPLIFHIYSYCILSTFNMSCTLFLDSDFILISLPYRFFTFFFLLLIFLFHLLYHANLNMSFTLLYYLLYLIHFSFLLFFRFVSIFLLSAFRSLTVLFHLAFPPLFQVYIFFTFLSLCLCFLFVLFVYFFIAILSLVFSLTKSFNVSLTLSMVRSFFFCSLFLSFFLSFFFLSLFKTFLLLSFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CBY8</accession>
    <name>A0A812CBY8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_36569</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001602">
        <property type="protein sequence ID" value="CAE1269403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CBY8"/>
    <dbReference type="OrthoDB" id="6282070at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134:SF22">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134">
        <property type="entry name" value="OS08G0543275 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1269403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="217" mass="25808" checksum="C933E3F4A5B714EC" modified="2021-09-29" version="1">MFPKRGHRHTFTISRFKEQSHLKETLWLSISRKEILLTPTDIVKIYINAPFFVLFLTKISVYLFSYLSIYLSIYLSFSMFLCVYQSVLMYVCMYVCIYVCMYVCIYLSIYLSVCSYVSISLFLSMYVCTYVCIYLSIYLSIYLSIYQSVYLSIYLSIYYLSIYVCSYVSIVSYLSIYLYLLVFYLCMYLPIFLSFSLLSIYLSIYLSIYLSIYQSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CCE1</accession>
    <name>A0A812CCE1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_33323</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001394">
        <property type="protein sequence ID" value="CAE1262665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CCE1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="304"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="336"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1262665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="364" mass="45407" checksum="83ADE56F851D4B13" modified="2021-09-29" version="1">MFRPNIHPGNQIDRLQETGGKENLFNIHYYLSIIYLSIYLSIYLSQPVPIYLYISIYLSLIFFFSFFLFPFLHCSVSSFFPFSLTFLFFFKKNMEILFFFLFIFLILFSLPFFLFFSFLSFFLSFFSLHFKPLSFPSFSFFFFLSFFFFFLLKFNLLFFVSFFLSFFFFLSFFIFLSFFFFFFSFFLFFFFSSFSFFSCTFICFSFPFFLLLSFFLFIRFPFFLSISFIFFLFSFFFFFFLLFFFFLFLFFLFLSFSFFLRFLSSFPSFSFFLEFLFSFFLFFENIQIFQNYSILISFRNFKNFNFPVLFQIFFFFLFYKNFILSFNFFFLSFNYLLLFSSLFSFFLFSFSFFSFLSFFFLKTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CCR1</accession>
    <name>A0A812CCR1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_31070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001262">
        <property type="protein sequence ID" value="CAE1258118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CCR1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1258118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="226" mass="26171" checksum="E9EB86A75B23B18D" modified="2021-09-29" version="1">MLYSLSLSLSLSLSLSLSPRHPHLQNIFFFFFFFFFFFFFFFFFSPFTSSTPSYPLFSSSYSFFSSSWILSKYCLLPYFLLISLSISLSSSHSHFPPNRFFLFVSFSLYFHLAFFPLPLSSFFFCLLTAKQCVPTTIDQPSSLESHFPPSLNINTFLLKVTSFFFALISIYHASLYILSYTSFFSSLPFSLCISFSFSFIFLNRFLFSLSLFSGSVNLLFSLPAEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CDK8</accession>
    <name>A0A812CDK8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_32243</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001335">
        <property type="protein sequence ID" value="CAE1260429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CDK8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1260429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="264" mass="31253" checksum="30288EB00BD125CE" modified="2021-09-29" version="1">MLPCGPSVPSSTFSDITDSCFMMPNYTQVYITFVHAVDKSLCPLIFPLLHHFLSFSLFVPLLCVCSFISFSLLFSFFSILSFPSSILFFPSSLSLSFFLPFFLSVFLSSLSFPSLDLYFFFCLLYPLLSLFSILFFHLHRSFSFLLRYLPYTFLSFFLTYLTFPILFFFYFLSYLTIPIRFFLSFFLSFFLSFLTIPILFFSYPFLSFFFLSFFLSFFLSFFTFPILSFLSFVINIHIIFFHFSLFLTRPSLSFFSFFLSFFLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CDL6</accession>
    <name>A0A812CDL6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_32254</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001335">
        <property type="protein sequence ID" value="CAE1260449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CDL6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1260449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="278" mass="31628" checksum="938F38890DA8FCE2" modified="2021-09-29" version="1">MSTFSQSFPTCSYLSIYLSIYLSIYLSIYVYSYLFIPVCSYLSLSVPIYLSIYLSSIYLSIYLTFHIYLSIYLSIYLSIFLSIYVCFISSIYLYLSIYLSIYLSQYVYIYLSIYLSIYLSIYLSIYLSESVHIYLSICVQSQSVHIYLYIYLSIYHCLFKSIYLSPLRVHNLSLSLSLSLSLSPAPPAQRSGSLLPKQLLREAECVFREGLPGPGSILSIFGKPFCSTQLSNALNMPSRIGWISSAHQHALLLVIFTSLSSVSRSFPAANFPALELRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CEW8</accession>
    <name>A0A812CEW8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_33484</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001402">
        <property type="protein sequence ID" value="CAE1262960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CEW8"/>
    <dbReference type="OrthoDB" id="10055437at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21523">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1262960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="290" mass="33943" checksum="3686C256378426A5" modified="2021-09-29" version="1">MLFLTFFSFSLFLFFFFFYFIYQIRSSFFPLVACHRKYIYIYLYIYSFIAFFSFLLSWHLPFLMSYFYLSLLFFFFIQFYFHLSFCCYFFRVVFCVNVKSLFGIYLFFSNRSLSKLTKPYHFSPCITKPYHFSPCITKPYYFSPCINKPYYYSPCITKPYHFSPCITKPYHFSPCITKPYHFSPCVTKPYYFSPCVTKSTTSLLVALNHTTSLLVSLNHTTSLLVSLNLTTSLLVSLNLTTSLLVLLNITTSLLVSLNHTTSLLVSLNLTTSLLVALNLTASLLASLKPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CKS5</accession>
    <name>A0A812CKS5_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="15">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">SPHA_35508</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">Farmed</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14 22">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 15">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="15"/>
    <dbReference type="EMBL" id="CAHIKZ030001530">
        <property type="protein sequence ID" value="CAE1267221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CKS5"/>
    <dbReference type="OrthoDB" id="10261556at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18794">
        <property type="entry name" value="SF2_C_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001389">
        <property type="entry name" value="ATP-dependent DNA helicase RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000340">
        <property type="entry name" value="Bloom syndrome, RecQ helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000495">
        <property type="entry name" value="RecQ family helicase MusN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="entry name" value="HRDC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002121">
        <property type="entry name" value="HRDC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018982">
        <property type="entry name" value="RQC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF153">
        <property type="entry name" value="RECQ-LIKE DNA HELICASE BLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00570">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09382">
        <property type="entry name" value="RQC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00341">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00956">
        <property type="entry name" value="RQC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50967">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 15 20" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="18">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="19">
        <location>
            <begin position="186"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="HRDC" evidence="17">
        <location>
            <begin position="518"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="625"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="627"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU364117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CAE1267221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="707" mass="80666" checksum="07233D05CB2A8BC6" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CMG0</accession>
    <name>A0A812CMG0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_36491</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001598">
        <property type="protein sequence ID" value="CAE1269281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CMG0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1269281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="263" mass="29593" checksum="DD3534BC6F030BBA" modified="2021-09-29" version="1">MSIYVSLTSHLSLFIPFIPPLSLFLSFFSLSLYIYLFHSVLSFFLSFFLSFPFCSYLSIYFSLFFSINLPLSLPLSLFLSLSLPSSLFLSFSLSLSLSLSLSLSLSVFYLFESVLFSLSIHLYHLLFLLSLLFGSDQYSYTPHPRRRHAFFHRFNRSASVYGIFFHFFLSNSSLPGKTDESYLLRPPSSSIVSYSSFLIFSFFSSLFSILFLFFLVFSSSSSSVAASAAAGKSLSSFFSSAVSLLSFDPAAPSIQRSIIDLHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CNV2</accession>
    <name>A0A812CNV2_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA polymerase subunit gamma-1</fullName>
            <ecNumber evidence="4">2.7.7.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Mitochondrial DNA polymerase catalytic subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">SPHA_42253</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Farmed</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
            <location evidence="2">Mitochondrion nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA polymerase type-A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="4"/>
    <dbReference type="EMBL" id="CAHIKZ030002057">
        <property type="protein sequence ID" value="CAE1280338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CNV2"/>
    <dbReference type="OrthoDB" id="5588663at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005760">
        <property type="term" value="C:gamma DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006264">
        <property type="term" value="P:mitochondrial DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08641">
        <property type="entry name" value="DNA_pol_gammaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000024">
        <property type="entry name" value="DNA polymerase gamma, catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019760">
        <property type="entry name" value="DNA-dir_DNA_pol_A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002297">
        <property type="entry name" value="DNA-dir_DNA_pol_A_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001098">
        <property type="entry name" value="DNA-dir_DNA_pol_A_palm_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047580">
        <property type="entry name" value="POLG_palm_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10267">
        <property type="entry name" value="DNA POLYMERASE SUBUNIT GAMMA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10267:SF0">
        <property type="entry name" value="DNA POLYMERASE SUBUNIT GAMMA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00476">
        <property type="entry name" value="DNA_pol_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00482">
        <property type="entry name" value="POLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00447">
        <property type="entry name" value="DNA_POLYMERASE_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0235">DNA replication</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1135">Mitochondrion nucleoid</keyword>
    <keyword evidence="7 17" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family A palm" evidence="16">
        <location>
            <begin position="224"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAE1280338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="553" mass="62565" checksum="53CB640B7EE3870A" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CQP4</accession>
    <name>A0A812CQP4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_41702</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002013">
        <property type="protein sequence ID" value="CAE1279316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CQP4"/>
    <dbReference type="OrthoDB" id="10266233at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1279316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="295" mass="33619" checksum="816EE753B42CA128" modified="2021-09-29" version="1">MASSATPAGVRIAMRAAIQLLGGGSLMWMMLLHNKPKQLFTLFTSISASSLSIYLSQSLHIYLSISLSLFTFIHLFQPLLYLSIYLSTSVSSHLSIYLFQPLLYLSIYLSLFTSIYLSISVTSHLSIYFSLFFIYLLQFLHIYLSIYLSLFTFIYLFQPLLYLSIYFSFFTSIYLSISASSLSIYLSTSVSSHLSTYLSISVTSHLSIYFSLFIIYLSIDLSLFISIYLSQDINIYSISVYSHLSIKPSLFTSMYLSTSVYSHLSIQLSLFISIYVYSQLSHSLHIFLFASIYIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CSQ9</accession>
    <name>A0A812CSQ9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_41427</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001989">
        <property type="protein sequence ID" value="CAE1278740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CSQ9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="330"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="387"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="413"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="442"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="509"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="538"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1278740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="573" mass="69700" checksum="8EA4354744F2E521" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CUM1</accession>
    <name>A0A812CUM1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_43580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002193">
        <property type="protein sequence ID" value="CAE1282622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CUM1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1282622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="316" mass="36735" checksum="1AF0A84B50240B0C" modified="2021-09-29" version="1">MFLATIFCQLFFFFNEFCSYLSIYLSIYLSISVFIYLSRFGKWLAGYLVLSYLSIYLSIYLSIYLSIPSGSHSSLVTYPYLFMYFPIYLSIYLSIYLSIYSKLSRSFISIYLSIYLSISVFIYLSRLGKWLAGYLVLSYLSIYLSIYLLNITGSTIALSDLSLFLFLSIYLSIYLSIYLSIYIYIKLSRSFISIYLSIYLSIYRFCTCVFLRCSLYLFINRYLAVTYNPSRPVRTSSAGKSLSHPYLRGFSHHLYRPSLNRRSFSSCAFVTSCVHQLLLSSLSLFSSFSPNLFRKKKNSLSSSIYLEKIKFILAMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CWB2</accession>
    <name>A0A812CWB2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_46008</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002403">
        <property type="protein sequence ID" value="CAE1286413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CWB2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="332"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1286413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="387" mass="46354" checksum="BD4DCAB9AF47F1D6" modified="2021-09-29" version="1">MPIKGLPSVFDKETKRLSGPQTVMDQRSRPLILQRNYGAFLYRDFDGHHRLVGGVSIYLIGLCLSTFIYLSIYLSIYLSIYLSIYIDSLFFIYLSIYLSIYLSIYLSIYLSISLCFHVCMYPFLSVCLYLSIYLSIYLSIYLSSQTKPEHLLSFFLSFFLSFFFLSFSFYFILFFVSFQSSVSFLFLSFFLSFFLSFFLSNLPSFSFSFISFFLSFFLLSFSFYFILFFVSFQSSVSFLFLSFFLSFFLSFFLSFFLIFRPFLSLSFHFFHFISFFLSFFLSFFLFSFFYPFLFISKNFVSFQSSFSFLFFFFLSFFLSFFLSFFLSNLPSLSFSFISFLSFHFFLSFFLSFFYPFLFISSFSLFLSNLPFPFFFFLSFFLSFFLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CWI5</accession>
    <name>A0A812CWI5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SLC15A1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_41516</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001998">
        <property type="protein sequence ID" value="CAE1278911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CWI5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1278911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="266" mass="31554" checksum="C6D724551DF46586" modified="2021-09-29" version="1">MFSILFFLSIYLSLYLSIYLSIYLYLNLSILYLLIFISIYLSLSSIYFIFLLYFYLSIYLSIYLSIYLSILDFYSSLKLLSIYLSIYLSIYLSIYLLSIYLSQSICSYLCISSILFSISIYLSIYLSIYLSILDFYSISIYLSIYLSIYLSIYLSILSQLFFLFFNLSSSIYLSIFYLSLYFSLFLSIYLSIYLSIYLSIFYLSINIYLNLFLSMYFSLFFSIYLSIYLSIYLRLLIFISICSYLCISVYSSLSIYLSIYLSILDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CWV4</accession>
    <name>A0A812CWV4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_45095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002323">
        <property type="protein sequence ID" value="CAE1285062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CWV4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1285062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="272" mass="32736" checksum="4DB68CD861AF4FBB" modified="2021-09-29" version="1">MFILFFLTLEFFLSFYLSLPIHIYLSIIACSYLSIYLWLFISIYLSIYLSIYLSIYLSIFACSFCIYLSIFVSLPVYIYLSLHVHIYLSIYLSIYLSIYLCLFIFYLSIYLSIYLSLIACSYLSIYLSIYLSLPVHFLSIYLSIYLSIYSCLFTPIYLFFLFFDPLFLITFFFSRCSFFSFISFFSILSSFFSLFLFFVFCLFFLFLFLYFSSTFSSSFYFLIRFSSALFFFFWLLMSFIRTLTYLSFLFIYSSSLLPFFIFFQTKNVGFRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CZL1</accession>
    <name>A0A812CZL1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_44681</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002283">
        <property type="protein sequence ID" value="CAE1284326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CZL1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="448"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1284326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="475" mass="56064" checksum="C6EEBEBE5BCC3E14" modified="2021-09-29" version="1">MGCLIPTKLLLLLIFFLSIYLSIYLSISVYSYYLSISFFIANNIFYLSIYLSIYLSIKFLFILSIHLSFIYPSIYLSNLSVALNYLSIYLSHLSKISIYPSYLYIYIFIYLLLYLSQLYSYYLSIYDIYLSIYLKKNSYYLSIYLENLSIYLSIYLYLSGICIIYLLIYLLSINLNIHIILSIYLSISVYSYYHLLSIYLSINLSIYLIYLSKKFYFLSFFLSFRKLNSRKSRDSNFRATDCFFSVIWIYSLIFFFSFYKLFFPLFKLLSLKSICNGRSSLASVRRTRILPWVRTSLIRVCSLQRLEAHCVFLVLSLTKKNPPHPARLTRPHTQRQYNGNLSVFFSTVSSRLNFARLTLSSLTHFLSLSFPSLSFPPLSSPPLYLFISFFLSKPPHHPTLSLSPSTSSYVILHRITPLCLKNLKNGILKSIYLSIYILYNLIKKNLHYIYIYLSSIYLSIYLSFYYLSIFRTKFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D1S7</accession>
    <name>A0A812D1S7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_48465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002700">
        <property type="protein sequence ID" value="CAE1290903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D1S7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="299"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="328"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1290903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="398" mass="47537" checksum="522DFB83EDE96167" modified="2021-09-29" version="1">MLTHSHCMYRSTLLTSPQKRHDDSSFFLNFFFSPTPLSFPFFFFYILLLELGKQKPSFSLVPLLSIFSFFFYSFLSVIAGIVSLFFFTFVHLILFFLFNLALTSTHFLYFIISLLFLSPFTFPFLFFFFFFKFTTYHLYYLYIVLFSFFFTSPLFFSFFFFFFHFPISILSFLFLLYYFSSSSSSLYFFFLSFLFYHVFFFSISFFLSFFFLLLLLIISTIFCSFFILFKLPPPLLLFFIYLFSSPDFILLDTHTHTLSFSFCLLLSIHLSSVSIYLSISIYLSIYLSIYLSTAFLSNYSLFLSIYSLFLSIYICFYLSILFLSISLYISLLLCIYLYTVCFCLSIYRLFLSLYILDFYLSIYLSISVLHCLLSQYFPISHLSFYFVQQALSFSLFIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D1X8</accession>
    <name>A0A812D1X8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_43738</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002214">
        <property type="protein sequence ID" value="CAE1282958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D1X8"/>
    <dbReference type="OrthoDB" id="10266233at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1282958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="229" mass="26180" checksum="D329396EC5322B80" modified="2021-09-29" version="1">MSIFFNPFISVSLSFYLCSYLSLSLSVFISVSVSLSLLIPVFLCSHLSRSLSSSFQICLSLSLSLSLSISLYLFNPFTAISLFVSIIFCSYLSIFTCPYLSTYLHVTLSTFHVSISTYLQVSISIYLSSCVHIYLYSCDHIYVPIFTYPYLSTYLHMTISPYFHMSISIYLSSSVHIYLSSCVHIYLHVFISTYLHISISSYLSSLIHIFLYIFTCPYLSSHVHIYLRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D4M1</accession>
    <name>A0A812D4M1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_48670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002722">
        <property type="protein sequence ID" value="CAE1291171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D4M1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1291171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="190" mass="21786" checksum="82970BFC2C42C68F" modified="2021-09-29" version="1">MSAIWDRTYNISLSVCRLVYGAAILDLVFCPFTLLLRHIPESTKVSNHSQIPVSLIFMSRDHCFGRICRAIIYPTHIYLSIYLSGSIIYLSGGIYFYYLSVSFFLSGLFIICLFIYHGPFLIYLSIYLSKSSLHIYLSIYLSIYLSQSAHLFSQSVDIYLSIYLSIYLSIYLSIMVSLLSIYLSGKMDTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D9G6</accession>
    <name>A0A812D9G6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PARP10_14_15</fullName>
            <ecNumber evidence="2">2.4.2.30</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_49358</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.30" evidence="2"/>
    <dbReference type="EMBL" id="CAHIKZ030002813">
        <property type="protein sequence ID" value="CAE1292603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D9G6"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02907">
        <property type="entry name" value="Macro_Af1521_BAL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11106">
        <property type="entry name" value="GANGLIOSIDE INDUCED DIFFERENTIATION ASSOCIATED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11106:SF111">
        <property type="entry name" value="MACRO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Macro" evidence="1">
        <location>
            <begin position="1"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1292603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="280" mass="30329" checksum="E4CA2E8751DD7559" modified="2021-09-29" version="1">MGDSLLVKVYQADILNVDVDGIVNAANKWLAHAGGVARAIINAAGDAVNIEGQRKRNGRALNDGEVLSTSAGNLTQYRNIIHAVGPINTPSSRNCEKKLEETVYNSLIEANQLGLCSVALPAISSGIFGVPLDICTNAYVMGVKEFYKTKPSDCQLKEIHFVDMNPVTCKAIKDDFAKQLSEVPAVTGNNIHQSKYNSANISSYEDMEVKAIDEKSLRCVACKKPLTGIIQGNHSPGTMSVKTDCLDPNNLRQVTACLADKKITPEDVAERNIKNHIVLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DFI5</accession>
    <name>A0A812DFI5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SYNGAP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_52746</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003323">
        <property type="protein sequence ID" value="CAE1298736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DFI5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DFQ0</accession>
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        <submittedName>
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        <subcellularLocation>
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        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <source>
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</entry>
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    <accession>A0A812DFY3</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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            <taxon>Sepiina</taxon>
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                <person name="Bekaert M."/>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <source>
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    </evidence>
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        <source>
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</entry>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <source>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="235" mass="26203" checksum="6C750943CD871ACB" modified="2021-09-29" version="1">MITSLVFLNTIFSLCSQALAAKISITSAQGLLSSISERDGENSLSYIIIYLFIYLFIFFFRQTAALWSDTSRTNPHHRQRRVRAGALLRGLRNADDNCTIDPRLTLVQHNFCTDFLFNRPTQKVLLLAIAASLAAPPHYQALVQSIDYQDIAGEIRHLLQQMVHSGLPSIFPIRLVLRDSFLCGGRFNSCGLRPHNNASIFSADNRPKNDQPLHTSNISEVLLGLGSPCLLLLHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DJB6</accession>
    <name>A0A812DJB6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_53366</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003391">
        <property type="protein sequence ID" value="CAE1299657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DJB6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1299657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="210" mass="25041" checksum="CEE4CE2AD0A871FA" modified="2021-09-29" version="1">MGHPTESHRLDVRLTALSHGSIRVCQRFFSLPMSFFLFLFYFKFNSFLYCISLILPPHSTFLPYFRIIYSLFSRFSSFLSFNYIFFLFIFHFVVISSFSLSYIKVFSCDILFLSTQFFFLLFYFVYFHYFSILHCCFTHSCLHALFFLASFILLYSSFHFLISLNILVFFLYFSLYFQHLYISPPPLISFFSFLHQSDSELDSSNTGTIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DL91</accession>
    <name>A0A812DL91_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_57043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003824">
        <property type="protein sequence ID" value="CAE1304468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DL91"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1304468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="337" mass="38486" checksum="27446C8C3C635231" modified="2021-09-29" version="1">MKGIVAHSFIIRQYLIRFANTFLATLFFFFFLSFFIPFFLSLFLFCYFPSRLFYLFISLLFSFFLSFFLSSFSFILFFLSFFLSFFLLIYFILSFFLPSHLFYSFFISFLFIYPASFHLLFSFFLFSFFLSFFLSFFSFDFYLFILISFCFYSILLSFFPPSLICYVSHALSLSIPHSLLQILSLTLSPLSSFSCSLSLSLTLSLSRTLSRTLSLSLGLSLIPFLSRTLSRTVSRSLTHILSLSQTISHSHSLPQVLSLSFSCALSDSRTISFSLTLSRTLSLSVSFSHSFSLALSHSPSLLPPLPPPPSTTSSSLPYLLLSSPPHLSNTHHQIADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DLN6</accession>
    <name>A0A812DLN6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_58982</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004081">
        <property type="protein sequence ID" value="CAE1306838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DLN6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="173"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="222"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1306838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="306" mass="36299" checksum="39C4178F64A1270F" modified="2021-09-29" version="1">MADQRTRLLSRLLHPLSISSSSSSSSSSSSSSSSSSSSSLPHFFFVFSPSSSSCSFSFFFFFFALSLSLSHRRAVAPPLSFYRYFHNFYCWLYFLSIYLSIYLSIYLSIYLIIFSIYLSIYLSIYLNIYCYIFIAGYIFFLSFFLSFFLSFYLSIYLSISLYIDLVCTNITSFFLYLIMGWWLVFLLSFFLSFFLSFFISLMNRHMAGFPSFFLSLMNRRAAGFLSFFLSFFLSFFLSFFLSFFLSLMNRHMAGFPSFFLSFFLSFFLSFFLFNEWTDSWFFPFLSFFLSFFLSFDLFWQNYCLSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DN81</accession>
    <name>A0A812DN81_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_57476</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003877">
        <property type="protein sequence ID" value="CAE1304916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DN81"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="312"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="359"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="391"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="427"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="468"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="503"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1304916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="551" mass="65638" checksum="1A03F0EBAF2EDCB2" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DP84</accession>
    <name>A0A812DP84_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_57316</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003863">
        <property type="protein sequence ID" value="CAE1304760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DP84"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="13"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1304760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="151" mass="17679" checksum="A3B8E0A08D1FC8E8" modified="2021-09-29" version="1">MSGYDICNLFLPIYLHIDLFIFIYLHIYLSIYLSIYLSIYLSSFIAIYLSLPLSTFIAIYLNILNVKSVSIYLILYLSIYLSNSVSIYLSIKFCIYLSIKFCIYLSIYLSIYLSIYQILYLSIYLSIYQILYLSIYLSNSVSIYLSNSVSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DQL1</accession>
    <name>A0A812DQL1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transmembrane protein 245</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SPHA_60576</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004214">
        <property type="protein sequence ID" value="CAE1308734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DQL1"/>
    <dbReference type="OrthoDB" id="5970161at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716:SF4">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 245"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01594">
        <property type="entry name" value="AI-2E_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAE1308734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="298" mass="32294" checksum="B4339A0D18C4D9AB" modified="2021-09-29" version="1">MDSIWLVLKGNVSLAFSFLTAVLSLLFGGGTALLNFIISAAIFLTTLFYLLASSGDQYKPVQWFTAFAPMQGGNSIGQAVEDAVSGVFMASLKMAAFYGLYTWLTHTIFSVNIVFIPSALAAVFGAIPFLGTYWAVIPAVLELWLVNREGLQAILLIVAHLLPTYVVDTAIYSEIKGGHPYMTGLSIAGGIYCLGLEGALIGPIVLCFLIAAISIYGNMLRGGGSEPNSSNPRAGGLPAVTLKRPDQLHDGDKRTPWGMTRYTISYSIHSNPFWTLQKHSLNFVILIVLILNHFSYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DQW8</accession>
    <name>A0A812DQW8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_60515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004213">
        <property type="protein sequence ID" value="CAE1308668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DQW8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1308668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="153" mass="17752" checksum="0D9EA6450F4AED9C" modified="2021-09-29" version="1">MSLSLVCSVRSNCLLSFFLSFFLSFFLSFFLSSSILFAIIPVSCVFCQQSVCISVFLSFFLSFFLSFFLSFFLSFFLSFFLSFFLSFFLSFFLSFFLTSSILFAIIPVSCVFCQQSVCISVFLSFFLSFFLSFFLSFFLSFFLSFFPVAFFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DS36</accession>
    <name>A0A812DS36_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_57514</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003885">
        <property type="protein sequence ID" value="CAE1305067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DS36"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="355"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1305067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="400" mass="48129" checksum="A0F376D0191EC06A" modified="2021-09-29" version="1">MRKPLFKIYIISFLFQSFFLLLLFFLSSVLSFFLSFFISFFISLPLSFLPLLSLASCIVDSISFLIYFLSFFLSFFLSVYFFLSYNCFLLLRDFRLAFLLSIVSFFLSFFLSFFLSFFLSFLLLSLPTLKCLILDSPSFLLYFLSFFFISFFFLFSFFLLFLSFFLSFFLSFFLSYSCFLLLQDFRLAFFLCFFLSLFVSFFLYSRFAFLLALFSFFLSFFLSFFLSFFLSFLQLISLARFRYVLCLTSTIFNLSFSFSITFLFFLTVFNPVFSTHFLCFFLSFYLFYHFFLCFFLYSRFASILALFSFFLSFFLSFFLSFYLSIYLSIYLSIFLSIYLSFLQLISLTRRFTRRFLSFFLSIYLSIYLSIYLSTYLFAFFVLPSFFLSIHSYFTLNPLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DXA4</accession>
    <name>A0A812DXA4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_61598</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004372">
        <property type="protein sequence ID" value="CAE1309953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DXA4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1309953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="209" mass="24843" checksum="0395143C4E464230" modified="2021-09-29" version="1">MNRIRIAPALIHCLLCYLVWRRRISLSLSLSLYLSIYLSIYLSIYLSQSFSYLSLSLSIYLSIYLSIYLASYPFHIYLSISVLFISIYLSIYLSIYMRVYIFFFFFFFFFFFFFFFFSSSSSSSNKSNLSHSRSQFFSSKWLNPFLPDHNILAGIFLFISIYLFNSVPIYLFNYVPIYLANYVPIYLSIYLSIYLSISVPIYLSIYLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DYD9</accession>
    <name>A0A812DYD9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_62636</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004486">
        <property type="protein sequence ID" value="CAE1311121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DYD9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1311121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="275" mass="32348" checksum="AC811953F68CCD0F" modified="2021-09-29" version="1">MFPLDWVIVTLCQCTETAISHLIFSLLFLFFFAIHLIPRHLFFSCLFVFSFLLQCLLLLLFFSPSFPHRILYPLSTLFLLLLPFPFFLFGSLLSLLFLPPFFSFIFSFSFPFLNFSSLSKNFRLFFLCSCFSHIFVSFVKFSFFFLCSYSTTIIFTPLFFSPHCSLPFFFFSSASFHWSIISLPPSYSFLLLLPHLFLSPFLIFLSPHTLLRFYSFSLFLPPLLFPIFDYIFFLTASSFFLLPILFYTFFILLQFLSSISHISLPHSFRPTSSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DYR5</accession>
    <name>A0A812DYR5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_64016</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004605">
        <property type="protein sequence ID" value="CAE1312832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DYR5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1312832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="160" mass="18979" checksum="4D54B9610765C731" modified="2021-09-29" version="1">MFILTNEELKFNLSVIIAMILTFFSYFFLPFLLLYHSSPFSPLFHFFPFPPSPLPPSFPPSCSCLIAIFFFFPLKKANILFFHFPSSGHRYVFSLSEISVFLFSRQRYGTVLHRRMKARIYALESAQEVFCLLRMLIYLSIYLSIYLSIYLSIYLRRNKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DYX1</accession>
    <name>A0A812DYX1_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Isovaleryl-CoA dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="5">1.3.8.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">SPHA_61121</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="25">Farmed</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the conversion of isovaleryl-CoA/3-methylbutanoyl-CoA to 3-methylbut-2-enoyl-CoA as an intermediate step in the leucine (Leu) catabolic pathway. To a lesser extent, is also able to catalyze the oxidation of other saturated short-chain acyl-CoA thioesters as pentanoyl-CoA, hexenoyl-CoA and butenoyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(2S)-2-methylbutanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-2-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:48256"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57337"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:88166"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:48257"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>3-methylbutanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = 3-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:12276"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57344"/>
            <dbReference type="ChEBI" id="CHEBI:57345"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="1.3.8.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>butanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:24004"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57332"/>
            <dbReference type="ChEBI" id="CHEBI:57371"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="1.3.8.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>hexanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-hexenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:43464"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:62077"/>
            <dbReference type="ChEBI" id="CHEBI:62620"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>pentanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-pentenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:43456"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57389"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:86160"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 20 21">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid degradation; L-leucine degradation; (S)-3-hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 21">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.8.4" evidence="5"/>
    <dbReference type="EMBL" id="CAHIKZ030004296">
        <property type="protein sequence ID" value="CAE1309419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DYX1"/>
    <dbReference type="OrthoDB" id="9988775at2759"/>
    <dbReference type="UniPathway" id="UPA00363">
        <property type="reaction ID" value="UER00860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008470">
        <property type="term" value="F:3-methylbutanoyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006552">
        <property type="term" value="P:L-leucine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01156">
        <property type="entry name" value="IVD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000001">
        <property type="entry name" value="Acyl-CoA dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000007">
        <property type="entry name" value="Isovaleryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000004">
        <property type="entry name" value="Isovaleryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034183">
        <property type="entry name" value="IVD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF12">
        <property type="entry name" value="ISOVALERYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 20 21" id="KW-0274">FAD</keyword>
    <keyword evidence="7 21" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10 21 25" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="24">
        <location>
            <begin position="39"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="23">
        <location>
            <begin position="157"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="22">
        <location>
            <begin position="266"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="18">
        <location>
            <position position="279"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="158"/>
            <end position="167"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="191"/>
            <end position="193"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <begin position="277"/>
            <end position="280"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="373"/>
            <end position="377"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <begin position="400"/>
            <end position="401"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00052875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR634183-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR634183-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR634183-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="CAE1309419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="451" mass="49459" checksum="1C9F3CDB66392D3D" modified="2021-09-29" version="1">MALRCLTSRICRRVLLGSRIPCRQMSAYYPINNDLFGLSDEQKQLREVVFQFAQKELAPKAKEIDHNNNFPGLRDFFLKCGEMGLLGITAPSEYGGSEGLYLDHCLIMEEMSRASGAIALSYGAHSNLCVNQIVRHGTEEQKKKYLPKLISGEFIGALAMSEPGSGSDVVSMKTKAVFKGDHYELTGNKFWITNGPDADVLVVYAKTDYDNPEAKHGISAFLIEKGMEGFNTGPKLDKLGMRGSNTCELIFENCKVPAENMLGELNKGVYVLMSGLDIERLVLAAGPVGLMQAACDISFEYAHIREQFGTKIGHYQMLQSKMADMYCSLNACRSYLYSVAQSLDKGNRAANDCAGVILYCAEAGTKVALDAIQILGGNGYINDYPTGRLLRDAKLYEIGAGTKVYLSIYLSIYLSIYLSISVCSFLSLSLSPSPPLSLSLSVSLSLSIYIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E071</accession>
    <name>A0A812E071_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_65860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004740">
        <property type="protein sequence ID" value="CAE1314863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E071"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1314863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="255" mass="31400" checksum="C4F74D288ED945B8" modified="2021-09-29" version="1">MRLLFTFTSTNSVSFFLSNCFLSFFFLSFMHPSILVSFFLPSIHSSFLSFLFSIIHPSVHPSFSFTFLPSFLFFFTHPSIHLSSLSFCVFFFLFRIFLSFYVFFFLFNFFFLFVLFFLFIYFISFSFFFISFFLIFCFFFLIFFYFLFTLFSSFSCPFFLLCFFISFFLFTYFLSFSFFYLFFFNFLFSYFLLLCFFFLFMSFSFILYFSFLFSFSFFLSLFSNVLSLFLFLFIYFLSFYVYFLSFYVILTFCLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E4Y3</accession>
    <name>A0A812E4Y3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LRP3_10_12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_66685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004816">
        <property type="protein sequence ID" value="CAE1315852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E4Y3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1315852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="247" mass="29398" checksum="AEBFEF775090827D" modified="2021-09-29" version="1">MIFIGCTCVYITILDSSYNIFEPYHCISIYLSIYLSIYLYILFFMSRTSRLWSSLPFSCFPRQTFFFFFFFLSFFLSFLFPLVSFILFSFFLPLSSFPFFSFSSSSFVSSFILLSSPLMFLSFLISFFLSFLPVFLSFFLFDFLLLLLFCPLSFFPYLLFHSFFLLSFFRLFFHSPFYPFSVLSFLISFLISFFLSFLSFFLSFFLSFKFPLVSFILSSFFLPLSPFPFFLSPLLLSSLLLFSFFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E6V9</accession>
    <name>A0A812E6V9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_67436</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004892">
        <property type="protein sequence ID" value="CAE1316799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E6V9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1316799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="216" mass="25331" checksum="3F7F37D9E6B69E57" modified="2021-09-29" version="1">MVTNCTKLGASHDSHNAAIIDANFSPVPDRRAYFFSLSFQTFFSLFKTYIYLSIYLSMFKYIYLSMFKYIYLSIYLCLSISIYLSISIYLSMFDIINVLELMFLYIYLSIYLSIYLSIYLYSLKCYIAIFCSFFFLAQMLIGYISVSILFQPSRLSVPNSTTATLGPLIIFIYITLLLLFYRPILTPSLFILSFFFFPSFLPLPFKFPVKKRFSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E717</accession>
    <name>A0A812E717_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_69306</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005070">
        <property type="protein sequence ID" value="CAE1318864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E717"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1318864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="208" mass="22779" checksum="54102B324CC22926" modified="2021-09-29" version="1">MRQCNKCGTTIEFTHSFMTDETGADSVLACTMARFGQLRSEVFFSLCGFSFSSSSSSSLPLFSGHVRRNLAPRVAAVIAVPPQPPDAAVQFDVVPDEAAALFDAAAPDAEVAALACCCCICFYVTYCRRVESRAGGEVAVFALSWRPPPFGPWWPYSPQLLLLMHLIVAPCSVRDTFSPSVRKGDFFSDPFHYLSIYLSIYLSVWCDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E721</accession>
    <name>A0A812E721_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_66890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004831">
        <property type="protein sequence ID" value="CAE1316068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E721"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1316068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="281" mass="30847" checksum="E0D3C9982E9A51A8" modified="2021-09-29" version="1">MKGNRIILAKAPEEIYLSIYLYLSKSVPDPSALNTNTYVVYEEESCEQSLSHSLFTSLSLSLYFSLSLSLYLSVSLLSPRFSRSLSLSLSLSLSLILSLTLVPLSLSLSFSLPFPLSLSRAHSLSHSLSYSFFQSFHKSFEIIPSCLHICTHSLTIPDNRVNASPLFKILEPALTGFHAQCHVQFCLHPLSLSLSLSLSLSLSLSLSQSISLSKIFSYITQTRVASLPLSPKSISYITAFSTPTPPRNEPSAVDITLAIPYPSTFPLFFLPASKAEINVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E7U8</accession>
    <name>A0A812E7U8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ArgK</fullName>
            <ecNumber evidence="8">2.7.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SPHA_68028</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Farmed</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">GTPase, binds and hydrolyzes GTP. Involved in intracellular vitamin B12 metabolism, mediates the transport of cobalamin (Cbl) into mitochondria for the final steps of adenosylcobalamin (AdoCbl) synthesis. Functions as a G-protein chaperone that assists AdoCbl cofactor delivery from MMAB to the methylmalonyl-CoA mutase (MMUT). Plays a dual role as both a protectase and a reactivase for MMUT. Protects MMUT from progressive inactivation by oxidation by decreasing the rate of the formation of the oxidized inactive cofactor hydroxocobalamin (OH2Cbl). Additionally acts a reactivase by promoting the replacement of OH2Cbl by the active cofactor AdoCbl, restoring the activity of MMUT in the presence and hydrolysis of GTP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer. Interacts with MMUT (the apoenzyme form); the interaction is GTP dependent.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.-.-" evidence="8"/>
    <dbReference type="EMBL" id="CAHIKZ030004932">
        <property type="protein sequence ID" value="CAE1317482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E7U8"/>
    <dbReference type="OrthoDB" id="1476984at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03114">
        <property type="entry name" value="MMAA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000647">
        <property type="entry name" value="Methylmalonic aciduria type A homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005129">
        <property type="entry name" value="GTPase_ArgK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00750">
        <property type="entry name" value="lao"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006958">
        <property type="entry name" value="PRK09435.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23408:SF3">
        <property type="entry name" value="METHYLMALONIC ACIDURIA TYPE A PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23408">
        <property type="entry name" value="METHYLMALONYL-COA MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03308">
        <property type="entry name" value="MeaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00056794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00062796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAE1317482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="332" mass="37320" checksum="242F74059AFC9BAA" modified="2021-09-29" version="1">MEEEDLSDNLLSRRKKPEKKVLCYSPPLQSMRQSMSVPYGFLSLSDSMVFLYLSIYLSDDDDDDLPGAGKSTFIEAFGKHLTSLGYKVAVLPVDPSSKITGGSLLGDKTRMPTLTLDENAYIRPSPSRGTLGGVTRTTNETILLCESAGYNIILVETIGVGQSEFMVSDMVDMFCLILPPAGGDELQGIKKGIVEVADIVIINKSDGDLAPAARRIQGEYLSALKYMRKRSRVWAPTVVRISSIKKLGIKELWERMAEFQTKMSSSGELFHKRKIQHKIWMWNYIKENILEMFREHPSVKSKLSHLEEQVDQRTINPGMAADILLREFMNRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E8B1</accession>
    <name>A0A812E8B1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NRP2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SPHA_70182</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005136">
        <property type="protein sequence ID" value="CAE1319959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E8B1"/>
    <dbReference type="OrthoDB" id="6160890at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000013">
        <property type="entry name" value="Membrane frizzled-related protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24251:SF30">
        <property type="entry name" value="MEMBRANE FRIZZLED-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24251">
        <property type="entry name" value="OVOCHYMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032831865" evidence="5">
        <location>
            <begin position="24"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="6">
        <location>
            <begin position="50"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="168"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="183"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAE1319959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="192" mass="22067" checksum="69F0DE3F62C52EF3" modified="2021-09-29" version="1">MTSRWLEETCFFVLFCFCRCTDSKLFSCHWVPFLLSWFDARQNGTPINSCNQTRINSPGFLSSPGYPRAYAGHTNCFYHLKAPSDNKIKLEFLVFDIQSNTHCRYNYLQIFDGPDMSYPHSEKHCGNQDLGFYYSTAPEILIRFVSTSSYYSGAGFHVRFSFHTSFTTDHSNQSGSDDIIEPMDGKLKNQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EC15</accession>
    <name>A0A812EC15_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_69560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005089">
        <property type="protein sequence ID" value="CAE1319113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EC15"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1319113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="278" mass="33384" checksum="B39DEAF9A3586697" modified="2021-09-29" version="1">MLHFLRLPFLLTVFFLLFFSPAQIVCSIYLSIYLSIYLSIYFSLFISINLIYLFIYLSIYLSLFISIYLSYLFISIIVCSLSIYLSIYLSIYLSIYLSILVCIYLSISSHHINLNLHDYFFHFFLVYSYLSIYLSIYLSIYLSIYVYSYLSIYLSQFIHIYLSIYLSIYLSIYLSMFIISIYLSIYVYSYLSIYLSIYLSIYLSLFISIYLSIYLSIYLSNIYLSQYINIYLSHFVHIYLSQYINIYLSIYLSIYLSIYLCVRSNINKRTPKWCVELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EEH2</accession>
    <name>A0A812EEH2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_69454</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005079">
        <property type="protein sequence ID" value="CAE1319021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EEH2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="109"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="149"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="183"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="295"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1319021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="329" mass="37047" checksum="868120AEF6CCA963" modified="2021-09-29" version="1">MSGSSSSSSSSSSSSSSSSSSLVLPLPLLRSLLPSSSSFYSLLLLLRLPPFFFVSAPPPSSSSYLPSSFFFVSALLLLSSQPSSFFFVSAPPPSSSPPLLLLRLRPSSFFFFLSFSLHSFSFNIIFFFSFSFLFCFLVSVFLLFTRPFLIFLAFSLIFSSFSFLNFLVSVFLAFSLIFSSFSFLNFLISVFLSFSLIFSTFSFLNFLVSVFSLSVFLAFSLIFSTFSFLNFLISVFLSFSLIFSSFSFLKFLVSVFFSFSLIFLHFPSLIFLISVFLSFSLIFSTFSFLKFLVSVFLAFSLIFSTFSFLNFLVSVFLAFSLIFFFIFLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EFD7</accession>
    <name>A0A812EFD7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ETV3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_73507</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005380">
        <property type="protein sequence ID" value="CAE1323559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EFD7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1323559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="152" mass="17432" checksum="ECC3EC73834AE741" modified="2021-09-29" version="1">MFFQIFFLISISLSLSFSVSVFLSISFHFSPSQRLSISLSFHFFFFLSPPKSSDLEFIKSIFMSPLSLFHSFFILFAFLFRSLSLSLGLPLWFSRNTLSLSRCLFNRFHFFIISSFSFSLDSPTLSLLPFSHFYSPSPGLIPVFASLSSSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EGJ9</accession>
    <name>A0A812EGJ9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_74901</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005442">
        <property type="protein sequence ID" value="CAE1325274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EGJ9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1325274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="229" mass="28841" checksum="D52AAC68924C0BF4" modified="2021-09-29" version="1">MLYFSVSFLHSFPRLSFFLSFFLSFFLFFFFFSFFLFFFPHFFFLSFFLFFAHFSFSFAFFPTFFFLSFFPTFFLFSFFLSFLFPSFILLFFFSFHFRSSSLAFRISNLFSPDFFVVFFHLFFLCIFPHILRFKFSTFFLLLMFPHYIFSIHSLFYYFSDFFEFFNSFFFSFFHFHLVFSSILFHFAFILFSFIFLPFFFLFFHFFWHYFSFLSLSFHSLFLSFFLSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EHH6</accession>
    <name>A0A812EHH6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_73263</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005370">
        <property type="protein sequence ID" value="CAE1323333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EHH6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032847767" evidence="2">
        <location>
            <begin position="30"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="337"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1323333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="357" mass="40718" checksum="866608B746D2F523" modified="2021-09-29" version="1">MIFLFLLPLPPPFSFLFLLPLLLPPSSSASSSSFFVFFFLLLLSPTTTTTISSSSSSSSSSSSSSYSSYSSSSSSSSSSLLFFFLLLLLLFLLLPFFLLLFHLSSFFFYFFFFFFCLLLFCPFLPSFFFSSSPFLFSFFFFFIFFLSFFFLSTSSSVVVFLPSFLFFFSFSSSVLLFFFLLPLFVSFFFFFPPFSSSSSSFSFLLFFLLSTPPPPPSSSSSSSSSSSSSSSSSSSYASFFFCLFFFLFLLLLFFFFFFLSFSSYFLFLLLLLLFFFFLLLLLPSPPSSYSSFFFLFLFLPPAHPSSSSSFFFLNLPPSSIFLLFLLLLRFLFYSPRLTFFVSYLPLFSTFLSLSGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EHS3</accession>
    <name>A0A812EHS3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_74632</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005435">
        <property type="protein sequence ID" value="CAE1324972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EHS3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1324972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="208" mass="26124" checksum="15D944EB756B2485" modified="2021-09-29" version="1">MTFFIFFHFLFFFCSSFYLCHFSFIFRFLFCSFLFFLFRFSVYSILYFSYISFLVFPSFFDFLPSFFVWFIFFFLFFFNFYLFLVFLLFPSFLPSFLPFFFFLFLSFFLSFFFLSAKENTSLLHFSFKLICSHFHFFLSFFLSFLSLIHFFAFLFFHFVRVSKSFFLSFFIYLFIYLFIYLFISYYPFFSFMLLSLFPSFFFIYFSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EJ28</accession>
    <name>A0A812EJ28_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_74514</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005433">
        <property type="protein sequence ID" value="CAE1324864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EJ28"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134:SF22">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134">
        <property type="entry name" value="OS08G0543275 PROTEIN"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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        <location>
            <begin position="761"/>
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        <source>
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        <source>
            <dbReference type="EMBL" id="CAE1324864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="780" mass="92259" checksum="4BF894B7E4BEB171" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EK45</accession>
    <name>A0A812EK45_ACAPH</name>
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        <submittedName>
            <fullName evidence="8">EFHC1</fullName>
        </submittedName>
    </protein>
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        <name evidence="8" type="ORF">SPHA_75340</name>
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        <name type="scientific">Acanthosepion pharaonis</name>
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        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Farmed</strain>
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    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005456">
        <property type="protein sequence ID" value="CAE1325732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EKT1</accession>
    <name>A0A812EKT1_ACAPH</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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            <taxon>Acanthosepion</taxon>
        </lineage>
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                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
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    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="CAE1328100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1328100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="230" mass="27220" checksum="14144B64FA038ECA" modified="2021-09-29" version="1">MGCTTSNTSGSNSGSTTKLNGQAPGTKPTNNGEAQIGKRFHLSLLALFSFFFSFFSFYFFLSLLLLYFFSFFLSYFSFSFFLLFISFPFLSFPFLSFPFLSFSFFLSFFSFSLFSFFPFFLFFFLSFRLFLFFLSFFLSFFLYFFITIAYKIKKTYKSIYLSIYLSILFLYISIYLSIYLSIYLSIYLSYSSIYLSIYLSIYLSIYLIPLHIYLSIYLSIYLSIYLSICC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EKU9</accession>
    <name>A0A812EKU9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="3 4">
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        <name type="common">Pharaoh cuttlefish</name>
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        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
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            <taxon>Sepiidae</taxon>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
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    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <location>
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            <end position="17"/>
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    </feature>
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        <location>
            <begin position="18"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="57"/>
            <end position="79"/>
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    </feature>
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        <location>
            <begin position="85"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1324560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="204" mass="22905" checksum="3448CA99054E17C6" modified="2021-09-29" version="1">MGALFLSLSLSLSPLSSLPVHSLSLSYCLTLHFFLSLFPHCHSLISHSFPFLSLFSIYSYPTFILFSLSIHFLSLPYFLNPIPSTYLSLSLSSLFPFSLLLYHFLLLPFSDLHSLFPHPLQAFLPPSLSLSLSVSLYHVSLSHFLSTSLFPVLNSLSPFNSLSLSLRSTLSFTLVFLIAFLLSHSISFHSLFLSLVLSLFYRCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EM53</accession>
    <name>A0A812EM53_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_78572</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005544">
        <property type="protein sequence ID" value="CAE1328957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EM53"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032827535" evidence="2">
        <location>
            <begin position="22"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1328957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="165" mass="18703" checksum="AD54858B6D4EF1A2" modified="2021-09-29" version="1">MNKVNLHLSFFLSLSLSLSLSLSLSLSFSLSLSDSVSLSFAQSFCPSLFVSNSFYLSLSDFLFLSLSFTLFISLFRVFFHTHTHTHSLSLSLSLSLSLFLSFSLFHSLSLARSLISLFLYHYLCLIHSIFISYHSLFITICLSFLFLLLPFLFIVFSRFPCPAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EN57</accession>
    <name>A0A812EN57_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_77077</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005503">
        <property type="protein sequence ID" value="CAE1327623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EN57"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1327623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="295" mass="34134" checksum="E430EE0CD53048E9" modified="2021-09-29" version="1">MISFYLSSFPFFLSFVFDFPFHFRPLFVSLIHFFLSFFLPFFLSFFLSFFLSFLSFTISVHSLSSLLPSLPSIFPPFLPSSLPPISFFLSFFLLLFCFLPSFLLFAFLLPSFLASFLAFFFTSFLPSSRPFFLPPFYPCFLPPFLSSSLPSIFPTFLPPSLPPISFFLSFFLSFFLSFFFILLPFLFIHFPLFFPPSLPSSLLSFLHPSLPFLSFFLSFFLSFFFVTSFLLFSFLPSFCFPPSFLASFLAFFLPSSLPPSLPPSLPPFLLPSLPFLSFFLSFLSFYHFCSFTHSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EQB1</accession>
    <name>A0A812EQB1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_78497</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005542">
        <property type="protein sequence ID" value="CAE1328889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EQB1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1328889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="259" mass="30476" checksum="F04F482376FE47A5" modified="2021-09-29" version="1">MLTFKYLQTFLAFHAFFLSLYHSILHAICSYLSIYLTFLFIFYLTLFISVCVFFLLFFFFLSIYLSIYLSIYLSIYLSQSVYLSLSIYLSLSHSILVFFFFLSIYLSIYLSIYFSLFISIYLSIYLSQSVHIYLSIYLSIYLSIYLSIYLSTYIRICIRLFVLVNLHRDILQSIRPSISSLAFYLSPPFSLSLHFSLSLSLLRMRSVLERFTFNVNSVISIQHPCGEQLKLPRPENCLLSLSLLISAKAFHDIHRDKML</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EQF6</accession>
    <name>A0A812EQF6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_75097</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005451">
        <property type="protein sequence ID" value="CAE1325461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EQF6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1325461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="299" mass="35563" checksum="C2795072F0101698" modified="2021-09-29" version="1">MIISKILSSGNNKLGLIYLSIYLSIYLSIYLSIYLSMFYLSLFLFSLSLYSHYLSIYIYISIYLSIYLSILFIYLSIYLSIYLYIYLACSHLSIIYLSIYLSIYLSIYLSIYLSFFASIYLSIYLSIYLSFFIYLSIYLSINLSTSACSHLSIYLSIYLSIYLSIYLLFSFSLSILASIYLSIYLSLTFIYLSVSVCIYVEVLKRYFFVEMPMFEMYWSEYFSPNTHNIYLSIYLSIYLFQNHRENLIYLFVRSFFLSFFSQPVHAWSAYLHLSIYLSIYLSIYLSIYLSIYLFQAVHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EQG7</accession>
    <name>A0A812EQG7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_78236</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005532">
        <property type="protein sequence ID" value="CAE1328560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EQG7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1328560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="158" mass="17887" checksum="3BC5B15D6D3830D6" modified="2021-09-29" version="1">MLESISLFLFLLFFTPLSLLIFLRIFLRISLLLDYPLSHLHLSLSFPLSLSLSLSLSLSLSLLFFSLPSVSSSFLFFLHTISLPFLLSPSSLYLCQFHLVSDPFLLSLFHTIFLPFLLSPPLSLCQFPLVSDPFLLSLFILYALPFLLSPPLSLVNFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ETT9</accession>
    <name>A0A812ETT9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SPHA_76803</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005498">
        <property type="protein sequence ID" value="CAE1327419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
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        <source>
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</entry>
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    </protein>
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    <organism evidence="2 3">
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="279"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="341"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="376"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1140441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="411" mass="47809" checksum="AAEBC396A9B6525B" modified="2021-09-29" version="1">MSLKKVITSIFLFFYNVIFLVSDSLVHSFFPFLLFLHIHVIKCPKSISIYLSIYLSIYLSISVYLSILFIYLSKSISIYLSIYLSIYLSIYVSYLYLSISIYLSIYLSIYLNLYLSIYIFLAGNIFYLSIYLSIYLSIYLTTTRDLNFSTASLVTSPYKRSSSSSSFFFFFFFFFFFFPLFLPPCSLFVLFFLFLAVLITIIFIILPYSSFSLFFFSSSFSNYYFVVVVPSSSSSSSSSSSSSSSCFFLLFFLFYSYCSFLFLAVLITIIFLLSFLIPLFSSLFIFFSSSFSNYYFVVVVPSSSSSSSSSSSSSSLFLIRIVLLILGCSYHYYFYYPSLFLFFLIFLLFLLLQLLFRCSCSFFFFFFSLFLPPCSLFVFFFLFLAVLITIIFIILPYSSFSLFFFSSSFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AKI1</accession>
    <name>A0A812AKI1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_602</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000013">
        <property type="protein sequence ID" value="CAE1140522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AKI1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1140522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="253" mass="28937" checksum="CABBECF01C9BAB20" modified="2021-09-29" version="1">MRVCVFVSRSLYYLSIYLSIYLSIYLSISVTSLSIYLSIYLSIYLCHFIIYLSIFVPPFRESFFFFFSLLLLLLLLFLLLLLLFLLFSSSVFFSSSSSSSSPPPPSFLLLLLIFLLLVIFLLCLSSSSFPRGLSLSPSSLSFFLSFFLSYSYTTPLPPPSSSLLLFSSPSSSSTRSFLLLPFLLRLSSCSFCSSLSFFLSFFLSFFLSFFLSFFFFSSSCLLLLFSVIFSLLFFYFSPSSSVFLFLLYRFFSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ANF0</accession>
    <name>A0A812ANF0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_2639</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000076">
        <property type="protein sequence ID" value="CAE1149217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ANF0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="297"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="342"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="398"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1149217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="432" mass="52252" checksum="5F17B78F224BD518" modified="2021-09-29" version="1">MSRKNYCNTFSFSFSETLSQISLIPFLFFFLSFSFSFFFLLSYFLSFFSLTFSFSFLLSPLSHFPSFFLFLTFLFSFFSLTFSFSFLLSPLSPFPSFFLLLSYFLSYFSPFFSFSFFLSFSYFLIFFLSFFSLTFSFSFLLPLFLIFFLSFFLSFFLSFFFLVSYFLSFFLFSYFLIFFLTFPLFLIFLLSFFFLLSYFLSFLLLSHFLSYFPLFLIFLLSFFFLLSYFLSFLLLSHFLSYFLLFLLFLLSFFLSFTFLFSFLLSPFSHFLSFFLSFSYFLFSFFLSFFLLSHFLSYFFPLSHFLSFFLSFFLSFFLSFFLTRENLEICFSFIPGPREIDCIHIYLSIYLSIYLSIYLFVHIYLSIYLSIYLFISHSVHIYLSIYLSHSVHIYLSIYLSIYLSIYLILFISIYLSIYLSIYLSIYLGLFISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AVH3</accession>
    <name>A0A812AVH3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_6546</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000214">
        <property type="protein sequence ID" value="CAE1160736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AVH3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1160736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="319" mass="39216" checksum="156E4144D62B6292" modified="2021-09-29" version="1">MKILSIYLSIYLSIYLCVKIHQFFFFLSFFFFVSLFLCFFVSFFSFIIVFLSFFLSFFLSFFLSFFLSFSFFLSFSLFLFLYFILCPFLSFFLSFFLSFFSFIIVFLSFFLSFFLSFFLYLSFFLFLCFFSFISFFVLFFLSFFLFLYYRFSFFLSFFLSLSFFLSFSLFLSFPLFHSLSFSFFLSFFLSFPLLSFFFLSFFLSFFIFLSFFFFVSSFSFISFFVLFFLSFFLSFFLSFFLFLYYRFSFFLSLSFSFFLSFFSFVCLFLSFSLFHFLFFFSFFLSFPLFLLLSFFVFFLSFFLSFTHSLTRLLIAILCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AVY6</accession>
    <name>A0A812AVY6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_5385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000180">
        <property type="protein sequence ID" value="CAE1157837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AVY6"/>
    <dbReference type="OrthoDB" id="6819399at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1157837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="171" mass="19750" checksum="BF9737885F30377D" modified="2021-09-29" version="1">MGGLKRHMKIHNNNQKAAVAHAIGLFNCNIYGKQCQSLVGLKSHIKILWPSSIYLSIYLSIYVFTIYLSIYLSISVCSYLSIYLSIYLSIYLSISVFSYLSIYLNLFISIYLYIYLSQSLHIYLSQFVHIYLSISVFSYLSIYLSESVHIYLSIYLSIYLSQSVLSIYLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AXU3</accession>
    <name>A0A812AXU3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_7726</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="CAE1163605.1"/>
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        <source>
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        <source>
            <dbReference type="EMBL" id="CAE1163605.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="267" mass="31961" checksum="6C668D4F840888AB" modified="2021-09-29" version="1">MSSCYLSIYLSIYLSIYLSIYLSILIISIYLSLFYLSIYLSIYLSIYLSNSVYLILFITYLSIYISFFSFFLLILLSIYLSIYLSIYLSIYLSIYLLLSSIYYLLSIYLSHPIYLSIYLSIYLSSVHYLSIYLFLSNSISLSIYLSIYLSIYLFLFLSFFFLCHPVNYLSIFLIFSIYLSMSVHIIYLPIYLSIYLYLYLSNSFSLSIYLSHFVFHLSIYFFFFFFLYHLLIIYLSIYLSIYLSMSLSIYHLSIYLSIYLSIYIILF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AYA0</accession>
    <name>A0A812AYA0_ACAPH</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_7265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000236">
        <property type="protein sequence ID" value="CAE1162492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AYA0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
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    </dbReference>
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            <end position="546"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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        <source>
            <dbReference type="EMBL" id="CAE1162492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="548" mass="64969" checksum="165EB044CBD6DAE9" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AYD8</accession>
    <name>A0A812AYD8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_7373</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
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            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000237">
        <property type="protein sequence ID" value="CAE1162663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AYD8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <source>
            <dbReference type="EMBL" id="CAE1162663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="630" mass="75995" checksum="307420EF32A568A2" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AYK4</accession>
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        <submittedName>
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        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Bekaert M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <source>
            <dbReference type="EMBL" id="CAE1164671.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0A812AZ40_ACAPH</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <organism evidence="1 2">
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        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
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            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000270">
        <property type="protein sequence ID" value="CAE1165216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AZ40"/>
    <dbReference type="OrthoDB" id="9942939at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1165216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="184" mass="20882" checksum="3278BBE113B79E54" modified="2021-09-29" version="1">MWSQMEPTRKSMWLQRNHLTEVRPRGNQPTRKCGYRGTNITEVLCGPQRTNLHESQGVVTEELTLTEVLCGPRGTNLHESQCGYRGTNLTEVLFDLVQEEPTYIKRLRGTNLTEILCVPRGTNLHESQCGYRGTNSLKFMVPEENQPTKVNVVTEELTSLKFFVVPGGTNLHESQCGLQENQPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B079</accession>
    <name>A0A812B079_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_7570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000242">
        <property type="protein sequence ID" value="CAE1163127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B079"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1163127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="170" mass="20196" checksum="EB0DDE0C217A9680" modified="2021-09-29" version="1">MNIISSSVPPYFFLSYTFINIISSSIPFFFHTFMNFSSSVPPYTFMNILPSSVPPYFFFPILFINIISSSVPPFFLSYTFINILPSSVPPYFFFPILFYEYNFFFCPSIFFLFLYFYEYNFFFCPSIFFLSYTFINIISSSVPPYFFLSYTFMNIISSSVPPYFFFPILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B121</accession>
    <name>A0A812B121_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_7977</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000258">
        <property type="protein sequence ID" value="CAE1164319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B121"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="304"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="340"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1164319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="375" mass="44244" checksum="61BCAE7D10E69B7B" modified="2021-09-29" version="1">MLTFICYCLLYHLNFFLSFFLSFFLSFHYNNHSVQKSLVIHANVHMLMSSVSLEFLSFFLSFFLSFHYNNHSVQKSLSLVIHANVHMLLSSVSLEFLSFFLSFFLSFFLSFHYNNHSVQKSLSLVIHANVHMLIYVSLEFLSFFLSFFLSFHYNNHSVQKSLVIHANVHMLLSSVSLEFLSFFLSFFLSFFLFLFIITIILSKSLVIHANVHMLMSSVSLEFLSFFLSFFLSFFLSFHYNNHSVQKSLVIHANVHMLMSSVSLEFLSFFLSFFLFFLSFHYNNHSSLVIHANVHMLLSSVSLEFLSFFLSFFLSFFLSFFLFIITIILSKSLCLLYHLNFFLSFFLSFFLSFFLSFFLSFFLAFFLSFFLSFFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B131</accession>
    <name>A0A812B131_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_8096</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000262">
        <property type="protein sequence ID" value="CAE1164635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B131"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134:SF22">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134">
        <property type="entry name" value="OS08G0543275 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="321"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="432"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="458"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="486"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="513"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="554"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="618"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="653"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="725"/>
            <end position="747"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1164635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="756" mass="87115" checksum="BFD991B4A01690E2" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B343</accession>
    <name>A0A812B343_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_9366</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000301">
        <property type="protein sequence ID" value="CAE1167377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B343"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1167377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="206" mass="23933" checksum="2696F6D7E744B872" modified="2021-09-29" version="1">MNIIYISGLNHKQIQTLIYTERCIHKPFPVSLPHRIHAETALKIAGKTQVGGRVLCLCKGNTSSRHSFAKGKQTTAQHIHSVLQNVFAHDFSLLFSCSFVYSFRPVPSFFTLSLMSSSPSIFIFTVFLSFFLSFIFHFFFYAFFFLTFFVRSVFLAFVCLFSPFPFSLSLFSFFLLYFQSVYSFSLINAYCFPLFLFCFFLCSFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B4Q8</accession>
    <name>A0A812B4Q8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_10226</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000330">
        <property type="protein sequence ID" value="CAE1168762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B4Q8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1168762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="290" mass="34315" checksum="74D698C1BDF3AC96" modified="2021-09-29" version="1">MIRSHCSCLSQSLHYLSVYLSIYLSIYLSLSLSLSLYIYIYIYIYIYISLLLPIYLSNLSYLSIYLSPLSIYLYLSLSIYIYIYIYIYIYISACSFPIYPISIYLSIYLSIYLSISVSSYLSIYLSFLSECIIFFFLDFLFHLSFLSFIFLSFSFFISFFIFSSFFLSFFLSFFLSFFLLTFLLFCLLFLLPSLSFFSPLSFFLSFFLSFFLSFFLSIVLFLNSFLHSVISFSFLFLPFLPFPPLCLYICIQTTYFVSFLPFCLYLSPSFLDLLFFSFYPCFTGHSPALQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B4W1</accession>
    <name>A0A812B4W1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_10684</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000347">
        <property type="protein sequence ID" value="CAE1169618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B4W1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1169618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="199" mass="22546" checksum="D7D92AF26F1E9D20" modified="2021-09-29" version="1">MLARIHADAYNLANARRGRKPGQAACCICSLALTHVMPAMRMQGAAMKRLLVWFVRQREAASRLPALAFKWIGRKPCCFSAKTPRQTAVYLSIYLSIYLSIYLSIYIYIYLVRVKSKAFPSLCNKSIYLSIYLSIYLSIYLSIYLSHVGFLPIHFKANACTRLAAFRFRTNQISKRFIAASCILIASITCVRAKLHMAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B8H9</accession>
    <name>A0A812B8H9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_11152</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000366">
        <property type="protein sequence ID" value="CAE1170558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B8H9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="492"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1170558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1057" mass="114325" checksum="C77F461A6F8DF081" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B9D6</accession>
    <name>A0A812B9D6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_12082</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000402">
        <property type="protein sequence ID" value="CAE1172523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B9D6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1172523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="361" mass="42713" checksum="37977F27C91B17C4" modified="2021-09-29" version="1">MIADGMNQGRISKQLSDILKERSVSLASLASYHIVLSIYLSIYLSIYLSIYLSIYIIDVYVCMYICMYISNYLSIWTSTLSLSLSNKFYLSIYLSIYLSIYLSIYLSIFIHIYLSIYLSIYLSIYLSIYLSITTCVYIYSIFNLFLSIYLSIYLSIYLSIHFVCIYLSIYLSIYLSIYLSHSFILLISFGFYLSIYLSPSFFHSHLVIIYLSIYLSIYLSIYLSVRIVLHHISNLSIYLSIYLSIYLSIYLSIYLSIYLFSMLALCISIYYNLFLYSYLSIYYILFVYIFYFQPAHIYLSIYLSIYLSIYHNLLSFFLSLYLFSLLALFISIYYNLFVSIYILKPAPIYLSIYLSIYLSIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B9Y8</accession>
    <name>A0A812B9Y8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_15874</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000556">
        <property type="protein sequence ID" value="CAE1226142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B9Y8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1226142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="242" mass="26586" checksum="FEE0BD3448C70DD0" modified="2021-09-29" version="1">MPIEIHYSHSLTHSLTHSLTHSLTHSLTHSLISSFTLTHLLPLSLTHSLTHSPTPPLFSHLFTYSFLSSSLTPPPLPPPPPHSPPVFLSHSLIPHSSSHSLSLTHFLFTILIFLFHFLLLLTPPPHSSSSHALIHSLSHCLSLSLTLSLIFSLTHFPSLSLTHSHSLSLSLSLTDFLSHLLTHSLSHTLSLTFSFTHPLTHSQSLTLPLPDSLSLPHSLTHFFAHSFCLALSLSLSLSHSHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BAI6</accession>
    <name>A0A812BAI6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_13736</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000461">
        <property type="protein sequence ID" value="CAE1175618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BAI6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="375"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="414"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="461"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="493"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="524"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="564"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="589"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1175618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="610" mass="69645" checksum="16D5EC011035A77E" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BCY3</accession>
    <name>A0A812BCY3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_14349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000490">
        <property type="protein sequence ID" value="CAE1176861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BCY3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1176861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="275" mass="34219" checksum="6B1B0945AFC7626D" modified="2021-09-29" version="1">MSITVSSFSLMPFGTLSLLINYRVPHFHFFFIFLSFFLLSSFFLFFLLFSFFFPSFFFLPFSFLHFSFFLPFSFFLSSFFLFSFFFPSFFFPSFFFLSFPSFFFLFFILFSFFLFPFFISPFFFLFPFFFPHFSFFLSFFLLFSFLLFSFFLFPSFFFLFSFFFLFSFFLSSFLLFSSFFLFSFLIFPFFFLFSFFFLSFFFLSFFFLLFFFFLSSFLLFSSFFLFSFLIFPFFFLFSFFLLFSFFLFPSFSFFSLFLFFLSSFSFNWNINKEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BLU3</accession>
    <name>A0A812BLU3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_22873</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000846">
        <property type="protein sequence ID" value="CAE1241523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BLU3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1241523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="217" mass="25788" checksum="8E44A8E367C228E6" modified="2021-09-29" version="1">MFPCKHACHDQRLCHLSNGQWTCLTSKSRCPFPFAVSLCCLSVFFSAPTITFSFIRLGSFQSDSFFLSFFLSFFSHLFPSFFLTSVISYFLSVLSFSFFKSFFFLSYTLLIFSSLSSFLSFFLFFLSFFLSFFLSFLRSFPSFIIFFLFIFSFLYFLLPFIYSFIPGVCFLSFFLSFFLFFCFSLLFLFLYIAEFLIYSFFLSFFLSFFLFSFFLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BMJ3</accession>
    <name>A0A812BMJ3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_19425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000705">
        <property type="protein sequence ID" value="CAE1234617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BMJ3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="332"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="387"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1234617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="410" mass="47225" checksum="79F3C4840220FF88" modified="2021-09-29" version="1">MEIGNKSNSTHPPTHTFSLSLSLSLSLFSSLFSPLFDIFPPSLSFPSFFPPPSFFITLFTTSHFSSHFHILFLLLSLSLSFILFFPSLFTTLFFPLSISFPLSLFLYFSFSFALFSLFLTPLSSPLSLPLSLPPLFPLSSPSLSSPRSLPLALSLPLSLFPHLSSLSLPLSLSSPLSLFLLLSIYISIPFISIYLSIYLSIYLHIVFSYLSIYLLFIFIYPSISFHIYLSIYLSIYLSIYLSIYLSSFSIYLSIVFSYLSIYLSIYLSIYRLFILIYPSISFHIYLSIYLSIYLSIYLSSFHIYLSLFLSLSLFISLSIYRRLFIIYLSIYLSIYLSIAVNLYLSIILFISIYLSIYLSIYRLFISISLSIYLSQFISIYNSFSYLSIYLSIYLSIYLSIYLSIYFPLHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BML7</accession>
    <name>A0A812BML7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_19411</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000705">
        <property type="protein sequence ID" value="CAE1234635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BML7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="291"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="327"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="391"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="415"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="450"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1234635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="480" mass="56847" checksum="1E35E8DC2F22081F" modified="2021-09-29" version="1">MISFTLSTVGQPPTETIPYRLEQSRNICLSTECSTRSNRHLSLSLFRKAETLQVNLQRPDFFLSSFFSFFIPHFFFLNFIFHFTFLPSISFFLSFFLSFFFSFPSDISIPLFPLFSFISFILLHSCLFIFLPSFPLIFLFLFKLVNPNIFSFASSFHSFFCLSIMIFVILNVFFFLLLPFCHAIVCFSSLCFRSFFFFPNLTSLLPLHSYSSHSPYYLSKTRFLISFTPFSFLFFSLQSIPTQVSKRCHKTVSWRINEIDKRFRFVHYLSIYLSIYLSIYLSIYLYQSVHIYLSIYLSIYLSIYPSLFISIYLSIYLSIAIDKRFRFVHYLSIYLSIYLSIYPSLFISIYLSIYLSIYLSIYLSQSVHIYLSIYLSIYLSIYLSIYLSQSVHIYLSIYLSIYLSIYLSVDPTTTLSIYLSIYLSIYLSIYLSLSVHMYRPQPAYIYVSQIFQFFLLSFTFINIYLSIYLSMFNSCPIILV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BN34</accession>
    <name>A0A812BN34_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_20751</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000762">
        <property type="protein sequence ID" value="CAE1237421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BN34"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1237421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="177" mass="21327" checksum="66CDBAEAE097D619" modified="2021-09-29" version="1">MYNPLILYHFVLPFSFFFSLFSFLSFFFLSFTFSYDISFSSFPSIILYKLFMSLFSITMFSCFFSFIVLLSFYMIIYILFYVPSFFITISFFMLHQFLLSFPASFIFYNMPHFAFSILFYHFLFLSLISILQSFPFSSFFFSINFSFIFSSIHYHSFTSSFSITLSFFPFLLQFISF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BQA2</accession>
    <name>A0A812BQA2_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_24843</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000934">
        <property type="protein sequence ID" value="CAE1245717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BQA2"/>
    <dbReference type="OrthoDB" id="412155at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06263">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000998">
        <property type="entry name" value="MAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051560">
        <property type="entry name" value="MAM_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23282">
        <property type="entry name" value="APICAL ENDOSOMAL GLYCOPROTEIN PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23282:SF101">
        <property type="entry name" value="MAM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00629">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00137">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50060">
        <property type="entry name" value="MAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="2">
        <location>
            <begin position="111"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1245717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="296" mass="33217" checksum="C9378F246124CFCB" modified="2021-09-29" version="1">MNGVGVGILRVVIAFATGGNNTLWELNRDQGNDWLFGQAPIKSPTSYKVFQSTILFVSSSFSLSLSLPPTSLFLTVCLPITFFFLPLSSSLFLFLVCLPNHFSFFFLTAGLNCTFDIGMCGWSQDTQDNFDWVENKGRTLVSGTGPSRDHNSNGTGFYLYIPKKNHYSNGKARLISPLMRPNGLQCFTVWYHMYGSDITTFNVYIFTGPKLGNPVFHRYGTKANKWLRADIQFSSRSPYNTENLSFSLLSLTGFLCLLSLSLTFWFSMSLSLSLSLWFSLSLSLSLWFSLSLSLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BUW2</accession>
    <name>A0A812BUW2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_24542</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000916">
        <property type="protein sequence ID" value="CAE1244961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BUW2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1244961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="197" mass="21905" checksum="29C1C49351501D7C" modified="2021-09-29" version="1">MLTITPRTHLSIYLSIYLSIYLSIYLSILVCYLSIYVIYLSIYLSLFLSLSLSLSLSLSLSLSLCIYLSHICMISSSSSSFSSSSSSSSSSSSSSYPDSPSSKDTELSMQVLAFRYLTIEAPIILSVQAGEEYAWLDIHYATYQRLRACQLLKRFLSSNGGTFTAHSSNEPDAQKRVFFSSFLSPFSLVLSFLAHLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BUX8</accession>
    <name>A0A812BUX8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_22205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000818">
        <property type="protein sequence ID" value="CAE1240206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BUX8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="321"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1240206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="347" mass="42295" checksum="14BD94664359A092" modified="2021-09-29" version="1">MFFFLFSFFLGFFLSFFIRLFFSFVPTFFMGSFLSSVLNVFLSFFLSFFLSTTMSFLLFFITFHLYSFLANLIHYYYAYPCHLFSSSPTPAIIFRNCLFISIYLSIYLSIYLSIYLAHSLFISIYLSIYLSIYLYIYIYDHIHLSVNIYMFISIYLSIYLSIYLSQSVHIYLSIYLSIYLSIYLSIYLSLFYRFLYLSIYLSIYLSIYLSIYLYIYIYIYIYMIIFIYLSIYICIYLSIYLSIYIYLSIYLSIYLNLLFFLSFFLSFFLSFFLSFFLSFFLSFFLHKYFSFVFIILFLSFFLCTDFSFFLHNSISFFVQPFLSFFIETFLSFFLSFFLSFVSLIKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BW36</accession>
    <name>A0A812BW36_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_22850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000846">
        <property type="protein sequence ID" value="CAE1241418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BW36"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1241418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="211" mass="24755" checksum="89B84581E11872DB" modified="2021-09-29" version="1">MSKMFLFFFLLHLSCIISSYNDILSFFLSFFLSFFLSFFLCKNLLVTFSSFPPIQTIYLNFSSSSFSFFKIEYLSIYLSIYLSIYLSQCVHFLSTYLSISVCFLSLFVYDSICLPINNPSYNIFKCVFNLSIYLSIYLSIYCKLLFVCLLSIYLSIYLSIANCYLSVFYLSIYLLQTVIRLSFIYLSIYLSIYLSIYLSISTLLNRICDLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BW69</accession>
    <name>A0A812BW69_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_24660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000924">
        <property type="protein sequence ID" value="CAE1245301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BW69"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1245301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="155" mass="17767" checksum="9843AB8497E2A9E1" modified="2021-09-29" version="1">MFSLLFSESISFLACFNLLFFCLSYSFSFLSYSQSSSLSHSLTCFKFFFFLIFRLCLTVDLSLFLTCFDVLYYPQNSSLSCLISLSLSLVLFFPFLITSYSQCSKLYNSFISLLSLLILNISLITLFIFLSLCPKSYLCSYFICLFLLSISLSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BW98</accession>
    <name>A0A812BW98_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_25326</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000957">
        <property type="protein sequence ID" value="CAE1246679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BW98"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1246679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="276" mass="32802" checksum="3BBD0EA393FB0FB4" modified="2021-09-29" version="1">MFIESVLNLSIYLSIYLSIYLSISFFLVLLLSISFFLSFFLILLLSIYLILFVFFLLCTYLILPLSIYLSIYLSIYLSISECSNIYFSFFQIIFFIDLFSYLFPFLNLSSFYLFSFSFSPYILLFLFNLSPFFGAFTLSSSLSFFSFFIPVLLFLLHSLLLFLLLHSIFLFLFHSYLSFITPLFSFFSHPFFSFFFIHTFSFFFTLLLFFAFLRVKSIYLSIYLSIYLSQLDSFSLFLSIYFRLFISIYLSIYLSIYLSIYLSICLSHLSKVDICQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BWV3</accession>
    <name>A0A812BWV3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_25566</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000968">
        <property type="protein sequence ID" value="CAE1247262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BWV3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1247262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="201" mass="22977" checksum="170B0D04C9EB1DB6" modified="2021-09-29" version="1">MMGTSSFFFKTFRIFTYIYLLKHLSFFSCFFLTFHIGSFFFLNSSYSSFDNSFFFCVLNFFFYVFLNSSSSSSSSSSSSSSSSSSSPISCVLFRIVPPTLLFTSAYLKFFSQPTLLLFQFPILVLILVRRRHFLLSCHFSQATSTFKWLASIAAVCSYGAFFLPRLSQNNLSIYHPHSPSLFLSLSLSLSLSLYPSIYIIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C2B6</accession>
    <name>A0A812C2B6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_27070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001040">
        <property type="protein sequence ID" value="CAE1250388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C2B6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="329"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1250388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="379" mass="45311" checksum="83C5FA8F8D76D9CE" modified="2021-09-29" version="1">MRLENPLRKYHISEQYIFKRAVSLSHSVSIYLSIYLSIYLSIYLSVSSICISLVIYLSVCESFFFSYFLCFSFFVFIYISMPVSFFLSFFLSFLLCFIYIPMSVDMYLSIYLYIYLFPVFFLSFFFLSFFLLSFFVFYYLFIHLFISVIYLSFFVSFIVFHLFIHLSIYSSIHYLSIYLSIYLSIYISFLLYYILPFFLSFFFFFLSFFLFTFTHFILPAFHVCIPFSHFLSISFPSFSLSLLNSYLSIYLSIYLSIYLSIYLTRLSHIYLSIYLSRLSLIYLSISSMSYLSIYLSIYLSIYLARLSHIYLSIYLSIYLSNSSKSYLSIYLSIYLGSVLSIYLSIYLSIYRISLSRLILSIYLSIYLSIYLSIYLTVFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C7J6</accession>
    <name>A0A812C7J6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_29822</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001193">
        <property type="protein sequence ID" value="CAE1255737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C7J6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="286"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1255737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="319" mass="38917" checksum="110AFCF4A34AE7F5" modified="2021-09-29" version="1">MVEFFSLSLSLSLSLSLSLSLSFLFFFFRTLLCFSFIPSFLPSFLLSYLPFFFSLFLSFTFFSFRLTLFPFPFYQFYLFLSFFLSFFLSVCLSVYLCMSVYISMSVQYLSIYLSIYLSICLSIYLSIYLSFLDYPFILTFFFFFFFSSIYFISFYFLFRKLFLCCFHFFIAVSSLSLIFFLSFFFSFSFLYYFFLIFLYFSFFYSLLCSFLPPLSFSFLFSFSFLLFYFRSFFLSFFLSFFLSLHRRIASSVTHYFLFFLSFFLSFFPSFLSFDCFFSFPVFLYPIFILFSFFSFFLSFFLSFFLPFFLSFFFPIFPFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CBE0</accession>
    <name>A0A812CBE0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_31899</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001324">
        <property type="protein sequence ID" value="CAE1259980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CBE0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="287"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="318"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="367"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="401"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1259980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="443" mass="53974" checksum="895F5A9D09CB1C76" modified="2021-09-29" version="1">MIFFFLSFLLFSFFFLLSSFFLTFFLFSFFFLSFFFLLSFFLHFFHSFFFLSFFLLSSFFLSFSFFFLSFFFLSSFFLSFFFLSFSLFAFFFLSFFFLSFFLLSFFFSFFRSFILSFCFLSFVLSFFFLSFFLSFVLSFFLFAFFLSFFLSSFFLFSYFILSFFFLSFVLSFFLFAFFLSFFLSFFLCISIIIFSFHSFVFFPGISFFLILFLVLLSFSQLSLYFILSSTFLSLYLLYLFSFSFPVSHSLSLSLSLFGLFCSLFFPSISFFLFSFHRFLSISILFSFMCRFFISLFFPFLFINLTFLSFYFFHSFLLSFFHFSFLVCLVFFLYLFFSCISFFLTFFLSFSFLYISFILSFFRFSFFVFLLFLSLFFSCIPFILFSIIVLISFFFRCISFSFLSLYFFLSFFLSFFLSFFLSFFYSISHNCFQDIILDLSYNNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CC70</accession>
    <name>A0A812CC70_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DCAF15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_32221</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001335">
        <property type="protein sequence ID" value="CAE1260254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CC70"/>
    <dbReference type="OrthoDB" id="6354267at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20917">
        <property type="entry name" value="DCAF15-NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038914">
        <property type="entry name" value="DCAF15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032734">
        <property type="entry name" value="DCAF15_WD40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28541">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28541:SF1">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14939">
        <property type="entry name" value="DCAF15_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDB1- and CUL4-associated factor 15 WD40 repeat-containing" evidence="2">
        <location>
            <begin position="32"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="462"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="591"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="309"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="462"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="603"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1260254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="732" mass="80601" checksum="B835D68F80F4C8F5" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CCF6</accession>
    <name>A0A812CCF6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_36798</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001617">
        <property type="protein sequence ID" value="CAE1269890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CCF6"/>
    <dbReference type="OrthoDB" id="9635126at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="313"/>
        </location>
    </feature>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="374"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="402"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1269890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="432" mass="51078" checksum="302EBF00B03ED5D8" modified="2021-09-29" version="1">MCVHLSIYLSIYLSIYQSIYLSIYLSIYLSIYLSLFRSIYLYIFISIHCDLCASIYLSIYLSQSLYLSMYLCICLCIYLFIYLNLFISICPTLFISIYLSIYLSIYLSIYLRLFISVCSYLSIYLSIYLSIYLSTPFHICLFISIYLCLFISVCSYLSIYAFSYLSVHIYLSIYTFSYLSVHIYLRLFISVCSYLSIYLSMPFHICLFISIYLSIYLSIYLSIYLSIYLCLFISVCSYLSIYAFSYLSVHIYLSMPFHICLFISIYLSTSFHICLFISIYAFSYLSVHIYLSIYLSIYLSIYLSIYLSIYLLLSVHIYQSVYLCLLSISIYLSIYLSIYLSIYLSHSVHIYLSIYLSIYLSIYLSIYHSVHIYLSIYLSIYLSHSVHIYLSIYLSIYLSMSIYLSIYLSIYLESFSVWYLSIYLSIIRLTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CD26</accession>
    <name>A0A812CD26_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_31951</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001324">
        <property type="protein sequence ID" value="CAE1259950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CD26"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="282"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
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            <end position="494"/>
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        <location>
            <begin position="580"/>
            <end position="599"/>
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        <location>
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            <end position="628"/>
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        <location>
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        <location>
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            <end position="696"/>
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        <location>
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            <end position="722"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="728"/>
            <end position="751"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="763"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="798"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="838"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="871"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="911"/>
            <end position="929"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1259950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="931" mass="112834" checksum="937BABB9D52FADAA" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CFE7</accession>
    <name>A0A812CFE7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_38108</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001724">
        <property type="protein sequence ID" value="CAE1273420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CFE7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="118"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="147"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="179"/>
            <end position="199"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1273420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="307" mass="35956" checksum="7351EEB1B131A86B" modified="2021-09-29" version="1">MAGAEEMWEIKSIYLSIYLSIYHNLFLIYLSIYLSIYLSIYLFLIYLSQSVPYLSIYLSIYLSIYLSIYLSICSFIYLSQSVPYLSIYLSIYLSQSVPYLSIYLSIYLSISICSLSIYHNLFLIYLSIYLSIYLSIYVSIYLFLIYLSQSVPYLSIYLSIYLSITICSLSIYLSIYLSIYLSIYVMSIHFSLMIFLFIYVSVCSYLSINSVPIYLSIYLSIYLSIYLSLRLGKDIHAYLSNCHVTVSTKSFTTSCCPVWTDAVKDLLRWRGIFLSFFLSFFLSFFSYVYSIYLSIYLSIYLSIYLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CGE8</accession>
    <name>A0A812CGE8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_33071</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
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            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001383">
        <property type="protein sequence ID" value="CAE1262179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CGE8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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            <begin position="73"/>
            <end position="96"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="147"/>
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        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
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            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
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            <begin position="221"/>
            <end position="238"/>
        </location>
    </feature>
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        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1262179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="283" mass="33100" checksum="8AC7041504EC2246" modified="2021-09-29" version="1">MLAPKRLSAATTNRLSFLSCSFHLFTLRKRCAKKKGGCKDEDRKRYSAGGQVRCAFMCESGGINDLAHNSNCLISFSFFFLSFISPFFSSLSLFPFSRSPFTSSFSSFHSFIHLSRLFSLFILSFTFLFSSFPFSILSFTFLFFSFSFSFFRLFFSSPFFFFLSFVHLFLLPFFHSFFHLFPPSIHFFFPNVFPSLFLFFLSPFISVFLVIFFFLSFFLSFFLSFFLSFFLSFFYICLPSLSPFSIYFTYLSSSILFFLSTLPFVFLSFPFLSHFLSSPLKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CIY8</accession>
    <name>A0A812CIY8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_36577</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001602">
        <property type="protein sequence ID" value="CAE1269389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CIY8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1269389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="296" mass="35046" checksum="1FB02BEEBDC4C320" modified="2021-09-29" version="1">MWSIHAHIIITYCKSIYLSIYLSIYLSIYLSITVYSYLSYLSVCLSVCLSIYLPITVYSYLSQSIHIYNSPVIYVNLSIYLSIYLSIYLSLVKYVYLSIYLSNYLSMTSLSISSFLSFSSSFFSSSSFFVFFLRLCLFLPLFLFFLFILFFLFSFSSSFSFTPSLYEVLCSLFILFGLLSSSLLPYLFSSSFSLISFLSFSSCFFFLFYFFLLFVVFFMSFFFFRLFIFLLFFFFSLFVFFFIFFLFLPLCLFLHIFLLLPRCLFTFLLFLLFLSVSSLSRLFFLLLIKPISSSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CL73</accession>
    <name>A0A812CL73_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_35760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001553">
        <property type="protein sequence ID" value="CAE1267797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CL73"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1267797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="216" mass="25031" checksum="477F651BC3FF093E" modified="2021-09-29" version="1">MSVMSSICTILLGILLASVLTSLFPQGLLTIPFLEYKNNNLSIYLSIYLSTYLSIYLSIYLILFRSIYLSIAFCSDLSIYLSIYLSILCSIYLILSISFIFFRSIYLSIYLSIYLSHSVQIYLSFSFCSDLSIYLSIYLILFRSIYLSHFVQIYLSIYLSIYLSIYLSISFCSDLSIYLSIYLSIYLSIYLSLLIYIYLCLAIVFCWHSPSKVTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CL81</accession>
    <name>A0A812CL81_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_36163</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001578">
        <property type="protein sequence ID" value="CAE1268614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CL81"/>
    <dbReference type="OrthoDB" id="6161264at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35151">
        <property type="entry name" value="ELONGATION FACTOR 1 BETA CENTRAL ACIDIC REGION EUKARYOTE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35151:SF2">
        <property type="entry name" value="ELONGATION FACTOR 1 BETA CENTRAL ACIDIC REGION EUKARYOTE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1268614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="216" mass="25762" checksum="4CC99A6D7CBA0998" modified="2021-09-29" version="1">MIFNCLSFFLLQTFIYVSIYLDLYLCIYLSRPLSIYLDRYLSRPLSIYLDRYHSVYLSRPFSVYLSRPLSVYLSRPLSIYLDRYHSISLSRPLSVYLSRPLSVYLSRPLSTVIYLSRPLSIYLSRPLSIYLSRPPLSIYLSRPLSIYLDLYLSIYLDLYLSIYLDLYLSIYLDLYLSIYLDLYLSIYLSIYLRLYLCIYRSGSLSLYLSIFIYSCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CND9</accession>
    <name>A0A812CND9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_38646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001767">
        <property type="protein sequence ID" value="CAE1274132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CND9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1274132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="304" mass="38801" checksum="AC1C5D2EEC1C64AA" modified="2021-09-29" version="1">MAIVYPSHHLSIYLSIYLSIYLYLSFFHSLSLNICGNDSAVHGRTSHDEDVWGLFFFQFPPFLETFIFFFPFHILFLPFHLFLEFICFDVFFFLKFYFLSFFFFFFLHEFLFFFFFPFFKFFSFFQKFFFFYPFLFFFFFFKNFFFLSFYMNFFYFFIFPFFIFLFFFLFFFQIFQMIFVVSFFLFFFISFFFFFFFSFYMNFFSFFLSFFCHFSFFFFFFLTIFYLFFLKNHRICFFLFYFSYLSFFYINFSLFCFLFFFFFNLFSFFLLSFIALSLSLFSYLSFFFLSCMNVSLSFFFFFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CPD0</accession>
    <name>A0A812CPD0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_38522</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001753">
        <property type="protein sequence ID" value="CAE1273933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CPD0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1273933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="254" mass="29933" checksum="7B93C1B75897CC7A" modified="2021-09-29" version="1">MYPFFLSAHRLTCSQRYYSQSSKLFPLFLLSLDKTLPDPRKVTAPPFLCNVWFFSITLFFLFICFLFFVFLFFLSFFLSFFLSFFLLEFLSFFSFVFLSFFPLEFLSISLSFFLSSFSSVFFPEDFPSFFHYGQLLSIYQTMHIHTSIYLSIYLSIYLSATISIYLSIYLSIYLSQPVHHIYLSIYLSIYLSIYVSLFVSIYLSIYLSIYLSVCLSVYTHLIYLSIYLSIYLSIYLSLSLSLSLSLSLSLKSSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CSX2</accession>
    <name>A0A812CSX2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_41136</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001968">
        <property type="protein sequence ID" value="CAE1278196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CSX2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="323"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="353"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="396"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="435"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="468"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="502"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="624"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="656"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1278196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="715" mass="84564" checksum="C9DC961B47725477" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CVP9</accession>
    <name>A0A812CVP9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_45710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002368">
        <property type="protein sequence ID" value="CAE1285932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CVP9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="290"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1285932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="373" mass="44223" checksum="0D3820B29C44A697" modified="2021-09-29" version="1">MAHSHVNSGIKEVKQKRLCTSNCYCDDTCVFLSFSNYFSYVFLPLPLSFLYPISFFFFVCFFASFFLSFTCLVSLLIGFAFVPPFLRPSFLSFYFCLLSFLFWPFFLIFCQSPSLSFIQYFSFFLFVCFCRSFTLSFYLCLSFFLSFFLSFFLSFFLSFFQAPALSFIQSFSFVYYFGYFFFLSFFLSFGYIYIYPFFHSLYDLFLSLLLFFPLSFCLAPPLFLPFSQFFRLFFFFFFFFCLAIFLSFRLSPILCLSNLLFFPRFFFYIFPMLLSISLFLSLTLSFTQSFSFFVSFFLFICFFLFPNFFFCFCVTICFCSCILHYCLVIGGAGGCAGNNGSSDYYYYYYCYSDGDNGEDHLFTKVSSVFLFVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CVR0</accession>
    <name>A0A812CVR0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_41963</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002024">
        <property type="protein sequence ID" value="CAE1279635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CVR0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="369"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="399"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="429"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="457"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="486"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="513"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="544"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="578"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="621"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="659"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="698"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="727"/>
            <end position="747"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1279635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="754" mass="89888" checksum="BA5B23ED7E40CC00" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CXC1</accession>
    <name>A0A812CXC1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_43208</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002155">
        <property type="protein sequence ID" value="CAE1282066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CXC1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="318"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="400"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="432"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="543"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="576"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="654"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="689"/>
            <end position="712"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1282066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="718" mass="81558" checksum="9B8FF4A4C83AF40E" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CY38</accession>
    <name>A0A812CY38_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_41885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002024">
        <property type="protein sequence ID" value="CAE1279640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CY38"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="332"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="462"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1279640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="479" mass="58205" checksum="B7590AB08D071328" modified="2021-09-29" version="1">MYVCIYLSIYIYIYICLFISIFLSHTVHIYLFIYLSHSVHIYLSQLAIYLSISFCSYLSQLGKYLSIYLSIYLSIYLSLFMSLFLLHTVHVYLSIYLSQSVHIYLSIYLSICFYSIHIYLSIYLSIFILFISIYLSIYLFLFFLYLSIFFTLFISIYCFFNSIHIYLSIYLSIFFSLNFWDESCFFQIFYFYPFILFFQTFSFLFKFIYFFLFLLLSQFSFFSCWPSLFSSCFYSYILLYSKYIFLHFSSHCNFYSFFYLSFMKLFSFSSIYSYFFFLLFIHSFFLFSLFFNDIVPCFIFYFIHSFFFSDLFFLLFSFILFLSFLLSSSFPFFLFSFLFLPLISFFSPFFFTTFFFLSFFVLFPSSLFLPSSLPSFLPSFLPSFLPSFIHCFFSLHFFNLFSVILHLFLCYFFLSFLIIFFFSFILSSFKSNILAIIFFHSYSFFLHSFFLSDILFLFTPSAYHLFLSFLFSLSFPSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CYV8</accession>
    <name>A0A812CYV8_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">THO complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SPHA_45861</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Farmed</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="5">Component of the THO subcomplex, which is composed of THOC1, THOC2, THOC3, THOC5, THOC6 and THOC7. The THO subcomplex interacts with DDX39B to form the THO-DDX39B complex which multimerizes into a 28-subunit tetrameric assembly. Component of the transcription/export (TREX) complex at least composed of ALYREF/THOC4, DDX39B, SARNP/CIP29, CHTOP and the THO subcomplex; in the complex interacts with THOC1, THOC3, THOC5, THOC7 and DDX39B. TREX seems to have a dynamic structure involving ATP-dependent remodeling. Interacts with POLDIP3 and ZC3H11A.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the THOC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002390">
        <property type="protein sequence ID" value="CAE1286189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="29024at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040007">
        <property type="entry name" value="Tho2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021418">
        <property type="entry name" value="THO_THOC2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021726">
        <property type="entry name" value="THO_THOC2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032302">
        <property type="entry name" value="THOC2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21597:SF0">
        <property type="entry name" value="THO COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21597">
        <property type="entry name" value="THO2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11262">
        <property type="entry name" value="Tho2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11732">
        <property type="entry name" value="Thoc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16134">
        <property type="entry name" value="THOC2_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THO complex subunit 2 N-terminal" evidence="10">
        <location>
            <begin position="7"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="THO complex subunit 2 N-terminal" evidence="10">
        <location>
            <begin position="409"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="THO complex subunitTHOC2 N-terminal" evidence="9">
        <location>
            <begin position="557"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="domain" description="THO complex subunitTHOC2 C-terminal" evidence="8">
        <location>
            <begin position="865"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1177"/>
            <end position="1545"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="888"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1207"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1252"/>
            <end position="1348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1361"/>
            <end position="1376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1398"/>
            <end position="1412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1419"/>
            <end position="1428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1429"/>
            <end position="1467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1473"/>
            <end position="1485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1486"/>
            <end position="1539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF11262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF11732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAE1286189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1545" mass="178162" checksum="A13417431F99DB7D" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CZR2</accession>
    <name>A0A812CZR2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_47541</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002578">
        <property type="protein sequence ID" value="CAE1289189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CZR2"/>
    <dbReference type="OrthoDB" id="10658992at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1289189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="343" mass="38747" checksum="A786EA78986CAB77" modified="2021-09-29" version="1">MLSLMLFITLFLTLVIMLFLTLVIMLSLTLVIIISLMLIYNACYNFLNACYNAFFLTNALYNACFLNACYNAFLNTCHNNFPNALYNAFLNACYNAFLNACYNAFPNALYNAFLNACYNAFLNACYNAFPNALYNAFLNACYNAFLNACYNAFPNALYNAFLNACYNAFLNACYNAFLNTCHNNFPNALYNAFLNACYNAFPNAFITLFLTLVIMLFLTLVIMLFLTLVIMLFLTLVIMLFLTLVIMLFLTLVIMLFLTLVIMLSLTLVTMLSLTLVTMLSLTHVIILSLTLVIIISLTLVVKLYSTLVTMLSLTLVVKLSLTLVITLYLTLVIMLFLMLVIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D018</accession>
    <name>A0A812D018_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_43492</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002187">
        <property type="protein sequence ID" value="CAE1282499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D018"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1282499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="281" mass="33063" checksum="7688B0ACC09E8E01" modified="2021-09-29" version="1">MSIYLSIYLSIYLFSPTSMHYPTHHLLVTTDLPPAASLSISFVGRISIIQREYPPHNRNFPMRIIFMLFHTIHFGFLDGPNYIYTSISMYIVFDLRHIYLSIYLSIIFIIYLSTYLSMSVYSYLYIYLCSLSMLVYSYLSMSIYSYLSIYLSIYLFVCLFYSISMQCLSHRFLSSPFLSVYLSIYLSIYLSIYLSIYLSVLIVHKLRNPSTVIRSFRDIKAVFLSFSTQTSPAWNRLNMQQCEENTEKGDIYLSIYLSIYLSISLHLNLLHFSYLSIYLSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D343</accession>
    <name>A0A812D343_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SPHA_45128</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002324">
        <property type="protein sequence ID" value="CAE1285088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D343"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51225">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="7">
        <location>
            <begin position="36"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAE1285088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="298" mass="36280" checksum="8A525CE57506E0E8" modified="2021-09-29" version="1">MNSTSSSFFSFFLFCLFLFFFFPLLFFPLLSSYLSSFLSSFRFLILFSFFFLLFLFSSFSLFFFFFFSLFSFFFFLSSFFFLFLPFLFSSFSFLSFFLLNFFLLFFFFFFLLFFFLFFLSFSFLIFSSFSSFLSTLSSTCLSSFFFIFSSFSFFFLFFFSFFFFFSYLFSFFFFFSFSFFSFFFFLPFLFSSFSFFFLFVFLPSFLSFLYFFSFFFFFLLLFFRRNFPVSHSMTYDILLFLCLSLSLSLSLSLSLIFIYISPFQQNILLFSFSFFLSFFLSFSPSLPLSFSLSLSLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D389</accession>
    <name>A0A812D389_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">nitric-oxide synthase (NADPH)</fullName>
            <ecNumber evidence="5">1.14.13.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">SPHA_45322</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Farmed</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NOS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.39" evidence="5"/>
    <dbReference type="EMBL" id="CAHIKZ030002334">
        <property type="protein sequence ID" value="CAE1285208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D389"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004517">
        <property type="term" value="F:nitric-oxide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050607">
        <property type="entry name" value="NOS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43410:SF1">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43410">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Riboflavin synthase domain-like"/>
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    </dbReference>
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        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="10" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0288">FMN</keyword>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="14" id="KW-0408">Iron</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0521">NADP</keyword>
    <keyword evidence="13 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="16">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAE1285208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="310" mass="35620" checksum="72408817E7112F55" modified="2021-09-29" version="1">MLNDFPSLKIPPTLLLTQLPLLQQRFYSVSSSPKFHPGEVHLTIAIAKYIKPNGVIHHGICSTWLQTCPVGEQVPCVMRAAPNFHMPEDGTRPIIMVGPGSGIAPFRSFWQQRKIDKEMLAVPRRKFHDPYGEKKGWGSMTIYFGCRDRNIDNIYESELKQYQEEDVLQDVYFGFSREPGKKKAVHIYRSNRSRLLSVPVFSYLSIYLSIYLSIYLSIYHFVYIHRPELTYVQHLLKKNSKAVCDAIVREGGHFYVCGDVQMASDVSDTVEMILKEDAPMSSEEAKNYVLKLRVCINVFLSFEFCKSFQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D4A9</accession>
    <name>A0A812D4A9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_49696</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002877">
        <property type="protein sequence ID" value="CAE1293221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D4A9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1293221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="197" mass="21858" checksum="A9C07244F8751849" modified="2021-09-29" version="1">MRIGNSLVLIQSSPPLHTVYLVRFSSLEQFVPTCVGLVVRNLHSSDRTVGFLSNGRNPYSSTNDFHISGWRDHHASNARIASIPSSRSYPRAFDVPPRRRLWHDSLRLLGRTESTPQQAGTPVNRRISILTVPCLASIALTIDQEHPVISADIVYPQHCRVDNGQCALLTRGQGLRPFACPGLIPSNPVLHGLTLWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D4W5</accession>
    <name>A0A812D4W5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_47558</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002581">
        <property type="protein sequence ID" value="CAE1289235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D4W5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="297"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="322"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="378"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="406"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="440"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="473"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="501"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="527"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="563"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="588"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="616"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="645"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1289235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="673" mass="85487" checksum="4C32FA111D07C8DF" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D5T9</accession>
    <name>A0A812D5T9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_47560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002581">
        <property type="protein sequence ID" value="CAE1289239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D5T9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1289239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="205" mass="23632" checksum="EB363587E7693A00" modified="2021-09-29" version="1">MKKSLVPFPSFFQSFPFPSFFQSFPFPSFFQSFQSFPVLCSFILSVIPFQSFQSLFLHSFSPFLSLHSFSPFLSLHSFSPFLVPSFFQSFPCSFILSFSPFLVPSFFLSVLSLFLFLHSFFQSFPCSFSFILSFSPFLVPFPSFFLSVLSFFPSFSPVLVRFPSFFQSCHHSLSFLPFNLFHDAFACIISLFQESFPFPPLSVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D6Q0</accession>
    <name>A0A812D6Q0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_46991</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002522">
        <property type="protein sequence ID" value="CAE1288232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D6Q0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1288232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="173" mass="18928" checksum="86640B4F42E91B71" modified="2021-09-29" version="1">MVDVQRNSVLINRTPHHIRDLFPHRLKMTAVISRLKATHIHRLFSAGPDHSSTEPAETDAEDNNGDANNERDQPTWPDPLTRLISWRGTVSLFFIFSLHQGSSSSKKTKDDGRTVVGGDDAGDGAESEEKLEVGDVGGEGGAGGDIGEDSPFSRSAFSWRIFCIFSQNDSFSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D751</accession>
    <name>A0A812D751_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_48476</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002700">
        <property type="protein sequence ID" value="CAE1290900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D751"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1290900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="299" mass="36498" checksum="2E73186AE6340610" modified="2021-09-29" version="1">MLIFHSYIFFNLTDQFFISFQFFLHIIFIHLFFLVFSIIFSIFTTFFFFILYTFSFNKLYFFILRDFLFSFLHNIFSPSFHNIFSFFLLKCFLLSKVFSFFKEASFFHSFFLPSQYFQYFLSFFTIFSLFIYFTTFSFLYLNLFSFILVHLLPFFPSSILSFTLFSFFSFFKYVLTFFLPFSFSGAGTRNEIYVLFFLRNFFPSKDTAWRLAFFLSVSFRNGSFCFPFFFFSKYFSELLSFFLSLFLIFFLSLSLILTLNFSFFLSLLFLQKISFFFFFPSLFVSNIKFLSFFSFLLCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D7S3</accession>
    <name>A0A812D7S3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_46739</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002490">
        <property type="protein sequence ID" value="CAE1287737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D7S3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="338"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1287737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="355" mass="42185" checksum="B7D5D70F4C65CD23" modified="2021-09-29" version="1">MSFSMCLLFPLIGEPFSLLLRKTSSFTSAFPYHRSSLLLLPCLAFFLNFHNLKPMSVCNYVKKIYLSIYLSIYLSIHRLHIYLSIYLSFSLSSIYLSIYLSIYLSIYLSILSILFISIYPFHRLHIYQFICHFLSHLSIYLSIYLFYFAHIYLSIYLSIYLSIYPPHRLHIYKFICHFHSYLSIYLSFSPCSYLSICHFHSHLSIYLSIYLSIYLSILIISIYLSIYLSIYLSIYLSIYLFTVFISINLFVIFTLIYLSIYLFNFAHIYLSIYLSIYLSILLTVFISINLSVIFTLIYLSIYPFHRAHIYQFVIFTLIYLSIYLYLSIYLSFPLSSYLSIYLSIYLLSHILLALI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D8E7</accession>
    <name>A0A812D8E7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_50587</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002998">
        <property type="protein sequence ID" value="CAE1294812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D8E7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="313"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="337"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1294812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="354" mass="41944" checksum="0CA04C73E0686AD2" modified="2021-09-29" version="1">MFCRAKCLLIVFISISLFYFLLFSQIFVPFHTIVSTYFSPFISIYIRLLYLIITFSSSLFLCLLSLFHVLSLFLFSFHVFLFVFFLLSFNFFFLRGFLFSSPFFLFLPIFSFIIVFPSTPSLFLYLLPCFLLFLLSFLSFYSFLFFFILFILFYSFSLLFFFSFSYLSLFPLFVPKNNFLPLINSKLLSFLSFRIFLFSFSHCHSYTNDRTHDNGDRVALSLSLSLSLSLSLSHSTIIRLSLSFWFYFLSPFSFFLLIPPPNILLSFPLLLLFRDYPFSCPLSSHPLSFSFLHCFAFSLSLIFASFLSFLLPFLLFSIPFLLILYIFFLLFFSRLPFSFPLFYLIALFLFLFIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D9Q8</accession>
    <name>A0A812D9Q8_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7041 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SPHA_48724</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002730">
        <property type="protein sequence ID" value="CAE1291362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D9Q8"/>
    <dbReference type="OrthoDB" id="6260718at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055469">
        <property type="entry name" value="DUF7041"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327">
        <property type="entry name" value="ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327:SF3">
        <property type="entry name" value="RNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23055">
        <property type="entry name" value="DUF7041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7041" evidence="3">
        <location>
            <begin position="3"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="185"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="157"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="195"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAE1291362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="256" mass="29095" checksum="459A8032B0899D77" modified="2021-09-29" version="1">MCLQLDAIFQARHITSQQSKFAAVVEKLPADVAAEVADILTSLPIDKPYETLKQAILHRSGFSEERKIRDLLTNVTIGDAKPSQLLRRMQQLLGDNDISTTVFRQMWRDKLPADIVRILAALADDVDIQKLATIADKVADTTPIRHISTTETVDGLVPDVNRQIQKLSSELQEISIQLRDLQKSHISRRDNFTKHNNHSSRSTSRHKYQQRRDRYQHANCWYHENFGARAKKCRPPCSYRKSFPSNQAGNGPAGTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DAU1</accession>
    <name>A0A812DAU1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_50067</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002922">
        <property type="protein sequence ID" value="CAE1293829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DAU1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="274"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="303"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="403"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="435"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1293829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="482" mass="56964" checksum="4DFA2B232B8A14AD" modified="2021-09-29" version="1">MPIRIICYLFISIPLFHCFSSSFSSLYLLHSFNCLYLSIYLSIYLSIYLSIYLHLNLIIYLSIYLSIYLSIYLSVLVGNVLSIYLFISIYLSIIHLSIYLSICPSRYVLSIYLFISIYLSIYLSIYLSIYLSICPIGTYYLSIYLSIYLSIYLSVLVGTYYLSIYLSIYLSIYLSVCPSLVRIIYLSVHIHLSIYLSIYHLSIYLSIYLSVLVGTYYLSTCSYLSIYLSIYLSIYLSIYLSICPSRYVLSIYLFISIYLSIYLSIYLSIYLSIYVSVCLHLNLIIYLLSIYLSIYLSVCPSQYVVFIYLFIFIYLSIYLSIYLYLCLHLNLIIYLSIHTSISLCIYLSVYISISLSIYLSIYLSIYLSIYRRTHYLSLFLFLRLHSHFRCQIRSISRSVFFFFFYNFFLIPSYMVLNSLFLPCCFFHFLLPFLSFFHFLSFFLSFFLSFISFLSFFLSFFFSRKPNGVSNMSFMSFIAINTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DBD4</accession>
    <name>A0A812DBD4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_52085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003209">
        <property type="protein sequence ID" value="CAE1297575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DBD4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1297575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="309" mass="33412" checksum="0CFACF199AD338B6" modified="2021-09-29" version="1">MSGSQAELVAFVRSWAVRPDVCVTQLRWQGGFGASARRGWLQPALGQQSSASPRRYYDCRPAFAEVNLLAEAGCADFAESGWGRPHVFDPPRVETVNKPGDGHPWRRFKGGGAPGSPPPWGGQAPARSHRSHSDRHGERIRAIAVRMGYYNLLLLACRDVAFRHAQPPCIRPNARTPDTPAMTAIAHHPRRTLNPQRRSACRRPHQCGGSAHSRRQYTSPRPSNRLTSAHNAHPIPVVRRARRASSCPRTPRQLTGGDAAMQRISTTSLAGSPRCGPKGYGHCRPSPPGALAGFSGGPASATPPAHGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DBQ9</accession>
    <name>A0A812DBQ9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_50074</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002922">
        <property type="protein sequence ID" value="CAE1293850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DBQ9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1293850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="238" mass="29073" checksum="170BEA2DD48A22A3" modified="2021-09-29" version="1">MILSIYLSIYDFTYLFFYDFIYLSIYLSIYLSMILHIYFSMILSIYLSIYLSIYLSIYDFTYLFFYDFIYLSIYLSIYLSIYDFPYLFSYDFTYLIIYYLHIFYISIYVSLILSIYLSIYLSIYLSIYLSIFLAYSKSIYIILFLSFFLSFYLSNLLYNLYHSVSFYLSIYLSIYLSIYFILFISIYLSSRSVFQRTSGYKRQLKCRNIQEKDNLYHSVSIYLSIYLSIYLSIYQKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DCE2</accession>
    <name>A0A812DCE2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_50370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002955">
        <property type="protein sequence ID" value="CAE1294409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DCE2"/>
    <dbReference type="OrthoDB" id="8092968at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043457">
        <property type="term" value="P:regulation of cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044792">
        <property type="entry name" value="TAR1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47188">
        <property type="entry name" value="PROTEIN TAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47188:SF1">
        <property type="entry name" value="PROTEIN TAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="506"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1294409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="643" mass="70512" checksum="8ECDC4F13BFFE240" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DEZ8</accession>
    <name>A0A812DEZ8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_52886</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003326">
        <property type="protein sequence ID" value="CAE1298910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DEZ8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1298910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="330" mass="37557" checksum="681218619A7B4326" modified="2021-09-29" version="1">MFCSHFILHGNSLLSFLHSFSLSNTSFSPSSTPLHPSSTHFSPPFRRFLSSIFRLFSLLYFSPFFLASIFHLFFSPLFFAFFHPTLLSFFFLTLLSFFLPTLLSFFLSSCLTFFLSHFLFLRVSLSPSRSLSPSLSFSLSLFLLLFLSFLLSPFLYLLLSPFLYLLLSPFLYLLLSPFLYLLLSTFLSPSFPLSLSLSFPLSLSSSFPLSLSAMLSLSPTTISPAFSPTFILLLFFHSVLSFFSHYLSLSLSLSLSPRKLSYVFHPLFKNLRCLILNAIISLFLSIVLSTSLYRSLLLSIVLFLSIVLYFSLSFSLLLSIVLYFSLLLFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DFF5</accession>
    <name>A0A812DFF5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SPHA_54287</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003516">
        <property type="protein sequence ID" value="CAE1301218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023616">
        <property type="entry name" value="Cyt_c_oxase-like_su1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000298">
        <property type="entry name" value="Cyt_c_oxidase-like_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50855">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50253">
        <property type="entry name" value="COX3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="310"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="392"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="451"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="507"/>
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        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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    </feature>
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        <location>
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            <end position="1005"/>
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    </feature>
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        <location>
            <begin position="1011"/>
            <end position="1037"/>
        </location>
    </feature>
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        <location>
            <begin position="1044"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1072"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1102"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1129"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1155"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1183"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1211"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1236"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1264"/>
            <end position="1283"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome oxidase subunit I profile" evidence="3">
        <location>
            <begin position="380"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="domain" description="Heme-copper oxidase subunit III family profile" evidence="2">
        <location>
            <begin position="567"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="domain" description="Heme-copper oxidase subunit III family profile" evidence="2">
        <location>
            <begin position="863"/>
            <end position="1156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAE1301218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1284" mass="157685" checksum="C3A02C9980F86DD9" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DG13</accession>
    <name>A0A812DG13_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_51135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003076">
        <property type="protein sequence ID" value="CAE1295876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DG13"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1295876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="302" mass="35470" checksum="E0FCDD030EAB65E8" modified="2021-09-29" version="1">MKAVQYLISISSLLMWPFYQLCQKDKRELFNTYLPLHNDTQDNCSTWLLYLMSVNADEVKNICFFLHIFISSHFFASSSFFITCSSILLSFTSFFFFSFIYHYKLFSCLTPNTKFVHTFFFKLSPFPANSTFSTSAFLPLPVLTPSFFFSSFFSSPSFSFLSSFFHSLSLLFHSPSFFYQYFSPPLYFLFHHLSFFFFSFLSLSLPSCVFPSFYPPLHIHSFFSCFSFPSSSFILLSFILISFIFLFLLLFSFLISNPYIFFHLPLFLPLFIPPHLTSFLFFLLFLPHSLLLPQKPTDKSID</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DJA7</accession>
    <name>A0A812DJA7_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SPHA_53980</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003454">
        <property type="protein sequence ID" value="CAE1300649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DJA7"/>
    <dbReference type="OrthoDB" id="6119737at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.10.10:FF:000007">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053134">
        <property type="entry name" value="RNA-dir_DNA_polymerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559:SF444">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559">
        <property type="entry name" value="TRANSPOSON TY3-I GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="9">
        <location>
            <begin position="132"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="68"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAE1300649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="267" mass="30206" checksum="C1103D639F26C2D5" modified="2021-09-29" version="1">MPILGADFLTHYALSVELASQTLTDTSTNVKRCGFISKYSTIGLTNIIPTANGYDEIIRQYQSLLTPSSRNEPVKHHAKHSIKTTGSPVHSQPRRLHPTKLKIARDEFDNMLKLGVIRPSKSPYASPLHMVTKADAISWRPCGDYRLLNAQTVPDKYPIPHIKDFALSLEGATVFTKLDLKAYYQIPIEEDYIQKTAITTPFGLFEFTRMPFGLRNAAQSFQRLIDEVLRGMPYTYAYIDDVLIASKSHAEHQEHLHAVLKQHNITD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DJJ9</accession>
    <name>A0A812DJJ9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_54201</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003505">
        <property type="protein sequence ID" value="CAE1301104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DJJ9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1301104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="229" mass="26952" checksum="0833990F7FBC43DF" modified="2021-09-29" version="1">MLYFCTFLFPIRTYIYIRLFFFLFNLTACLLSIIFIFSLFPSDSLITILFLYLFLSFFLSFFFVSFFFSTFLSFYFSFFLFFFILFINVIHIYLSIYLSIYLSVCLSVCSFCLYLHTDSLSLSLSLSLSIYLLESFEIYVNHFISIYLSILLLISGSLILSVSYILLTPHTSHLSFFFLSFSFFLSFFLSIYLSIYLSIYLSVSCSLYLLSLYLSLSLSVYLSIYLCVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DMJ9</accession>
    <name>A0A812DMJ9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_56721</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003780">
        <property type="protein sequence ID" value="CAE1303994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DMJ9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1303994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="204" mass="23756" checksum="21CFDB88E910708D" modified="2021-09-29" version="1">MTSGETAPKENIQSTSYPILFYLSIYLSIYLSIYLSIVLSSLLSYPLYLSIYCLILSISLSIVLPYLSIYLSIYLSIYLSIYLSIVLSSIYLSSYLLSYHLSIVLPSLSIYLSIYLSIYLSIYLLSYHLSIYLAIYLSIIYLSIYLSIYLLSYPLYLLSYPLYLFIYLLSYPLYLLSYPIYLSIYLSIYLSIYLSIYCLILSIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DRT1</accession>
    <name>A0A812DRT1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_59563</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004123">
        <property type="protein sequence ID" value="CAE1307483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DRT1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1307483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="228" mass="27032" checksum="5EBAD20F15283480" modified="2021-09-29" version="1">MHFSIYTIPYSYLSIYLSIYLSIYLSQSLIYISISSLLYLSIYLILFIIYLYIYICIYVFSAVDNLSIYLSIYLSIYLSIYLSIYLSIAVSSHLYICLSLYLILFIIYLSIYLSIYLSIYLSIYLSIYLYIYIILTSIYLSIYLSIYLSIYLSPSSSLYLSHLYFIYLSIYLSIYLSIYLSIYLILFITYLNIYICIYVFSAVNNLSIYLSIYLSIYLSIYLKLDIES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DTP2</accession>
    <name>A0A812DTP2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_62417</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004461">
        <property type="protein sequence ID" value="CAE1310888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DTP2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1310888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="219" mass="24860" checksum="90EDA468A53F5B0D" modified="2021-09-29" version="1">MTGTNSPSANLHGCNCAFCPAHPPCFMILFLVGEKQTPAQVLARQPLIHNVKAERPLLCSYLSIYLSIYLSIYPSLFIFISLSHPAHISPLSLSVSVYIYIYIYIYIKCACVCVFQSVHIYLSIYLSIYLSIPSVHIYLSIYLSIYLSIYLSIYPSLFIFISLSHPAHISPLSLSVHMQRLSKQTNNHIRAISDNLFPPPCYLSIYLSIYLSIYLSIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DVY7</accession>
    <name>A0A812DVY7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_63359</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004540">
        <property type="protein sequence ID" value="CAE1312063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DVY7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1312063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="201" mass="23388" checksum="7BC3079B64A1DB88" modified="2021-09-29" version="1">MFVIFISCIYPFSLFIFYPFSLFILLFLPLSHPWPVFLSLVVAARLSFFLACPSLSLSLSPPYHSGHISLTCPNLYVSLSHVIIAHLFFFLFLCLSFLNYSVLPLSSLFSVYPFFYISNIFFFLSLSLHSSFCQKLKRHLEISFSKLHKREHSNPVSKIIIYCQNVLHPTDCPFIFKMIAERTVKSQFFFESIYQMPAMTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DVZ2</accession>
    <name>A0A812DVZ2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_63489</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004549">
        <property type="protein sequence ID" value="CAE1312218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DVZ2"/>
    <dbReference type="OrthoDB" id="10683757at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="436"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="174"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="202"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="226"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="457"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1312218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="522" mass="54513" checksum="2F59D63D6B331E25" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DX13</accession>
    <name>A0A812DX13_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">SIX3_6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SPHA_61898</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SIX/Sine oculis homeobox family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004391">
        <property type="protein sequence ID" value="CAE1310261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DX13"/>
    <dbReference type="OrthoDB" id="3501850at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000046">
        <property type="entry name" value="SIX homeobox 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031701">
        <property type="entry name" value="SIX1_SD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10390">
        <property type="entry name" value="HOMEOBOX PROTEIN SIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10390:SF33">
        <property type="entry name" value="PROTEIN OPTIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16878">
        <property type="entry name" value="SIX1_SD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6 7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="121"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="7">
        <location>
            <begin position="123"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAE1310261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="186" mass="21810" checksum="51E1595AFEC4EDF7" modified="2021-09-29" version="1">MLNFSPQQVAQVCETLEDSGDIERLGRFLWSLPVNPAASEALNKHESILRARAIVAYHTGNFRDLYHIVENNQFTKDSHAKLQAMWLEAHYQEAEKLRGRPLGPVDKYRVRKKFPLPRTIWDGEQKTHCFKERTRNLLREWYLQDPYPNPTKKRELAQATGLTPTQVGNWFKNRRQRDRAAAAKNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E1Q7</accession>
    <name>A0A812E1Q7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_62747</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004489">
        <property type="protein sequence ID" value="CAE1311341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E1Q7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="405"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="437"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="467"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="495"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="523"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="550"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="577"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="607"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="639"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="676"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="721"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="753"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="776"/>
            <end position="797"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1311341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="798" mass="95029" checksum="2080AEA7B4B2512D" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E1R9</accession>
    <name>A0A812E1R9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_63113</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004529">
        <property type="protein sequence ID" value="CAE1311751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E1R9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="169"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1311751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="225" mass="24641" checksum="0B502F36FE2FF944" modified="2021-09-29" version="1">MSLFKQSTKHNLSLYYPVTQSLLFLFPAANLYPSLNKAFSSKCTTTDYSIPALCQMLSWKLQLVFRHQAATTDKRGRGLSSSSSSSSSSSSSSSSSMFQAFLLSLSLSLSLHLPVSLLFLLRSTPLLPITTTTITITSTTTGETISRTTTNRNIAINTSSFIPLPHFRFCIVFLLIIIIVVVAAAAAAAAAFIFFLSLYLSQPVQIYLSIYLSIYLSIYLSILTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E374</accession>
    <name>A0A812E374_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_65396</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004722">
        <property type="protein sequence ID" value="CAE1314399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E374"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1314399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="294" mass="34631" checksum="489D1010344940A9" modified="2021-09-29" version="1">MQITSQRHSLSFSLYLSLSLSLFLSFLLSFFLTPLLSFFLSFFLSFFLFFFSSVTPLYLFLTPHFSFFLSSPFLSFFLSFFLSFFLSFLISSLFLTPLYLILISNFSFFLFSFFISHPSLFNSYFQFFFLSFFLSFFLSFFLSFFFFLSFSLQLFISHSHSITVSQPSLFIFSPTLFLSFFRSFFLSFLLLRKAVFFIQPPTHIVSLFLTTYFFYLSSLLFFPLTSFRTFVLFLSSFSYRLPSIFYSLSLCLFSIVLVISPLFIRPPSIVSFLSSPFYRPSSIFYLLTSIVSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E7K5</accession>
    <name>A0A812E7K5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_68550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004991">
        <property type="protein sequence ID" value="CAE1318064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E7K5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1318064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="210" mass="23363" checksum="858B01B4BCB5556A" modified="2021-09-29" version="1">MKRSSSFGGSVFKNPKLTDSVLSRIKKRPRIQDITNRRDTGVRNKWKNTLQRKVTGSFRRRALKQMVDYSWGVSPGLPGRSIFSPPSSPSAKVPESTTPSFASSSVPAVFLTPAAVNETPIRCPRRKRRPAPPPPVQVDKKEKAKFANKIKVQIYLSLSLSLSLSLSLSLSLSLSLITKVPLLDDTSIIQMSQICLPPPPRYRPPQQPYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E8T6</accession>
    <name>A0A812E8T6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_68842</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005028">
        <property type="protein sequence ID" value="CAE1318416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E8T6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1318416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="173" mass="19412" checksum="6A7C5310676E4331" modified="2021-09-29" version="1">MTPPPPICLLLRITGSPFLDHVHHTSGPSNLKRFSSINITFLKSTWFVIHLLELPILASLCFLLCTVRTLTSSSHFSFTFFAVTFSPDDNNFVTLLFILLSVLLEIVFSVYSSSSAHTTYRNTEIVFFPPYSPFYISPFHLNEFPPTPSLSLSLSLSLSLSDVLKLSLFFGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E910</accession>
    <name>A0A812E910_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_68274</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004961">
        <property type="protein sequence ID" value="CAE1317764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E910"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1317764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="252" mass="29842" checksum="FF5A17D7F86B394F" modified="2021-09-29" version="1">MQPSGSQCSFLCEYKPRAKEYLSHFTTANLFQRDHSNSHTPYPPPLSLSLSLSLSISRFSLSTHFNFSRFLFSDCFLLFLYHPDIYLLVSISLHLASYSLIPFTVFSDRHFFFLFRHQHIWEHFSVNLLAYFFFFRYIDFSSDNFLPIYSSRYLGISAVKFWILIFFQTSSHYLCFDHRLCFSTPSHSFYPSLPSFLPSFLPSFLPLFVSFFLSFFLFLPASYITCLFPCIPSYHKPITFYNKGLLFSFFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EAG3</accession>
    <name>A0A812EAG3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_68665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005007">
        <property type="protein sequence ID" value="CAE1318151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EAG3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1318151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="194" mass="22306" checksum="2348F21D5D62BA63" modified="2021-09-29" version="1">MARSGFSQCGRYLYSDGDSGGKRKRKLYIWARVVPSSLATQIKINVCYNDKLYLSIYLSIYLSIYLSIYLSRLFSLHPVRVTGIHPTSFHIFFYQLISISFLPHLPMACSSIYLSIYLSIYLSIYLSIVLFISIYLSIYLSIYLSIYLSIYHSVHISLSIVLFISIYLSIYLSIYLSIYLSIYAVFSSSSKGPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EC82</accession>
    <name>A0A812EC82_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Receptor ligand binding region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SPHA_68582</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004998">
        <property type="protein sequence ID" value="CAE1318085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EC82"/>
    <dbReference type="OrthoDB" id="5984008at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000337">
        <property type="entry name" value="GPCR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050726">
        <property type="entry name" value="mGluR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24060">
        <property type="entry name" value="METABOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00248">
        <property type="entry name" value="GPCRMGR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032443557" description="Receptor ligand binding region domain-containing protein" evidence="9">
        <location>
            <begin position="18"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="294"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Receptor ligand binding region" evidence="10">
        <location>
            <begin position="100"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAE1318085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="325" mass="36271" checksum="04FD666D5AA14946" modified="2021-09-29" version="1">MISFTVLYCLGLCYVYALNIHHTYGVSGKSHYRVSKERNLQTGKNNDEGTSSQRRTKCGDSTGNNIKLGDLNIGSVISLHHAIDITTCGKANYTQRVKLAEAIKFAVENINRRTDILNNVTLGYVILDDCTSTTMALARALQFMPQEMRERGIRRTKDNTGSSANAKQESLVCHPVSNFETTSKTTDSTPPVDDISVSSITSTGFLTTSESPSVSSINSTSFPTTHKERDITIATESHQKGLDRREEFFTEYYDVIGVVGADTTKLSLAVSSILTLFQIPQLNRKFTNDLFCDLLYFLSFFLSFFLSFFLFFLISLESLARVFTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EFY6</accession>
    <name>A0A812EFY6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ADCY1</fullName>
            <ecNumber evidence="2">4.6.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_72900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.1" evidence="2"/>
    <dbReference type="EMBL" id="CAHIKZ030005350">
        <property type="protein sequence ID" value="CAE1322998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EFY6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="312"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="362"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="387"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="412"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="436"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="462"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="490"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1322998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="571" mass="63421" checksum="83DAAA606C9DA9FC" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EGK9</accession>
    <name>A0A812EGK9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_72713</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005341">
        <property type="protein sequence ID" value="CAE1322800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EGK9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1322800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="348" mass="40553" checksum="36470B7E683ED662" modified="2021-09-29" version="1">MFLYNYVFLMVTVLIIRLLIINVRILCLLIMTVLIIRLLIINVRILCLLIMTVLIIRLLIINVRILCLLIMTVLIIRLLIINVRILCLLIMTVLIIRLLIINVRILCLLIMTVLIIRLLIINVRILCLLIMTVLIIRLLIINVRILCLLIMTVLIIRLLIINVRILCLLIMTVLIIRLLIINVRILCLLIMTVLIIRLLIINVRILCLLIMTVLIIRLLNVMFSYVFLMTVLIIRLLLINVRILCLLIMTVLIIRLLIINVRILCLLIMTVLIIRLLIINVRILCLLIMTVLIIRLLIINVRILCLLIMTVLIIRLLIINVRILCLLIMTVLIIRLLIINVRILCLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EGX0</accession>
    <name>A0A812EGX0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_72107</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005293">
        <property type="protein sequence ID" value="CAE1322086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EGX0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="299"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="328"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="356"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="401"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1322086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="437" mass="53030" checksum="C43FD191A6886591" modified="2021-09-29" version="1">MLLASSNIPSFLLSSSYIFFLSFFLSFFLSFFLHPLKYSCISFCIFSYILSILRLIFFLSFFLSFFLSFFLSFFLSFFLHPLKYSIFFLSFFLSFFLSFFLSFSVQYFLSFFLVGRYNLFISPASILSLFGQILFLSFFSVQYSFFFSFFPSFFLSFFLSFFLSFFLSYSLFLYFFLSFFLSFFLSFFLSFFLSPSNIFFFFLSCRQIKYIYFSGQYPFLILPDIISFFLFRPIFFLSFFFFLSFFPFHILSFFLSFFLSFFLSFFLSPSNIFFLSFLSSDIIYLFLRPVSFPYLARYYFFLFFPSNILSFFFLSFFLSFFLSFFLSFVIYSSFLPSFLASNIVFIYLFHKIFSLSFFLSFFLSFFLSFFLRPIFFFLSFLSADKIYLFLRPVSFPYFARYYFFLSFPSNILSFFLSFFLSFFLSFFLSFFFLSSQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EHM4</accession>
    <name>A0A812EHM4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_71043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005201">
        <property type="protein sequence ID" value="CAE1320866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EHM4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="338"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="390"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="421"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="453"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="541"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="599"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="651"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="705"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="738"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="771"/>
            <end position="790"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1320866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="799" mass="92599" checksum="80BB6027CF8BE7BE" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EIT8</accession>
    <name>A0A812EIT8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_71999</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005285">
        <property type="protein sequence ID" value="CAE1321991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EIT8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1321991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="203" mass="24765" checksum="0239307BA48AD3F5" modified="2021-09-29" version="1">MLTFICYCLLHFFLSFHYNNHSVQKSLSSFFLSFFLFSFFLFLFIIIIILLLSFFLSFFLSFFLSFHYNNHSVQNLLSFFLSFFLSFFLSFFLFHYNNHSSSVLLKCLSFFLSFFLSFFLFLSFHYNNHSSSVFLFFIFFFLFLFLSFFLSHLLSFKILPAFIFEPCFCLSIRIIHPYYQTLSVYRLLKEYLFLLFSVQFRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EK13</accession>
    <name>A0A812EK13_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_75281</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005454">
        <property type="protein sequence ID" value="CAE1325647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EK13"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1325647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="329" mass="39675" checksum="4FC4C8311F19FE26" modified="2021-09-29" version="1">MSVSFILLFFFLHFFFHFHSNLNSFLYPSYHRSFFHFSSLLLFSFFFFSFFLFHLSSLLSFVFLILLKFSFFFFLPICAIIFVDTFSFFHHFFSLSLCFSRFNSFFFLPSFLLIFFQPFPLFLGCIIFPNFHSSYLFFFFQTSLIFLLYFLFDIFTHFLLFLSPFPFFLQPFLTLFLSPAFSLLPFFLLPFPDFLSFSCLFLTSFISTAFSLFPFFFLPFPHFLSSPSFSLFFPFPPWLDSSAFPFLSFPFSFPFFLQLSFLPASFPDFLFFLLPFLTSFFFQPFFYFFFLPFLSFFLLPFPLLSFCLLPFPDFLSFSLFPDFLFFPFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ELA7</accession>
    <name>A0A812ELA7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_76687</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005495">
        <property type="protein sequence ID" value="CAE1327151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ELA7"/>
    <dbReference type="OrthoDB" id="7457938at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36162">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36162:SF20">
        <property type="entry name" value="GLUTAMINE-RICH PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="656"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="825"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="879"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="656"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="703"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="825"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="879"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="898"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="918"/>
            <end position="931"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1327151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1234" mass="138978" checksum="C3F43A28CD52E0C3" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EPK7</accession>
    <name>A0A812EPK7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_76553</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005493">
        <property type="protein sequence ID" value="CAE1327007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EPK7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1327007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="333" mass="38232" checksum="92A7D3CBCC810751" modified="2021-09-29" version="1">MASDTLTRIQEDSWRLDGISYTEEHSGRQLAFGWHLIHGTAFRKTAGVWMASHTRNSFQEDSWRLDGISYTELHSGRQLAFGWHLIHGIAFRKTAGVWMASLTRNFIQEDSWRLDGISYMEQHSGRQLPFGWHFIPEQHSGRQLAFGWHLLHGTAFGKTAGVSMASHTRNFIQEDSWGLDGISYMEQHSGRQLPFQRHFIHGIAFRKTPGIWITSHTRNSIHEDSWLRSSFIALFDGLVLLLLVSVSLSRFKRRQFSSLLSTLLMRSLTTLIYLSIYLFIYLSIYLSILSCLHHLRESVPVSSAAIEIFGRLPYLRVVSQQRPVRVGRLACSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EQZ2</accession>
    <name>A0A812EQZ2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SALL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SPHA_78845</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005552">
        <property type="protein sequence ID" value="CAE1329281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EQZ2"/>
    <dbReference type="OrthoDB" id="9998363at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032267755" evidence="3">
        <location>
            <begin position="23"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="451"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="479"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="514"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="798"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="832"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="873"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="965"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="997"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1044"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1074"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1108"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1137"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="102"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAE1329281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1168" mass="129303" checksum="C638FDF3AA86AEAD" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ET80</accession>
    <name>A0A812ET80_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HS3ST3</fullName>
            <ecNumber evidence="3">2.8.2.30</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_79039</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.30" evidence="3"/>
    <dbReference type="EMBL" id="CAHIKZ030005555">
        <property type="protein sequence ID" value="CAE1329591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ET80"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008467">
        <property type="term" value="F:[heparan sulfate]-glucosamine 3-sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="852"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="886"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="498"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="754"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="380"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="500"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="543"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1329591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="916" mass="103402" checksum="B9B44DEA2795011B" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EYB9</accession>
    <name>A0A812EYB9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_80881</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005612">
        <property type="protein sequence ID" value="CAE1331749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EYB9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1331749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="325" mass="37006" checksum="A533D74327A0CD8F" modified="2021-09-29" version="1">MCLSIYPSSFLSIYQSEFVLYLSIYLSIYLSIYLSVCLTLSKHEASPSLALFPSTFIYFFLTLSTVFLCLFITFTSLSDSFSFPVSFLLYPLSLSLYRFPLTYPHILFSRPLIHISFLLFLNYSFAIHLCVHSSLASSTLSLLILSRLLSISVPLSLSLSLSPYRFHCPLSLFLLFFLIWLYQVEVGRSISLSLSFFSLFFFFSLSLSLSLSVLSLFFIYFPLKSPLSLFLALSFSRSLSLYFFLSRFQSLFLSSSFSLPLFLSLFFSLFFSLFNILSSSFSLSFSLSFYRFLISIFSLSSLSLALSLSINSSSPHYPDPSLFPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EZK8</accession>
    <name>A0A812EZK8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DPH7</fullName>
            <ecNumber evidence="2">3.1.1.97</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_81492</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.97" evidence="2"/>
    <dbReference type="EMBL" id="CAHIKZ030005634">
        <property type="protein sequence ID" value="CAE1332448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EZK8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061685">
        <property type="term" value="F:diphthine methylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1332448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="163" mass="18533" checksum="7FD8D1CA603F88D7" modified="2021-09-29" version="1">MFVFRVDTEICLSLSIDWSFLTRLFSRLFLLFISIFLLFLFFFDLFSISSLPPRSSSIPISLLSFSASITSPIDVTCYFISISFLFYIYFLLPPLSQPLPPLSLGSFYSLFLFSLGSFYSLFPLFSSSFFSLSSLSAYSLVSSFFSSLYFLSFLSLSSLAYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812F0R0</accession>
    <name>A0A812F0R0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PKN2</fullName>
            <ecNumber evidence="5">2.7.11.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SPHA_81266</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.13" evidence="5"/>
    <dbReference type="EMBL" id="CAHIKZ030005629">
        <property type="protein sequence ID" value="CAE1332213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812F0R0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004697">
        <property type="term" value="F:diacylglycerol-dependent serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.160">
        <property type="entry name" value="HR1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036274">
        <property type="entry name" value="HR1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46585">
        <property type="entry name" value="HR1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="141"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="179"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="324"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="360"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="4">
        <location>
            <begin position="195"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="37"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAE1332213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="385" mass="43678" checksum="724CF893300DDA1C" modified="2021-09-29" version="1">MAEGGTSYFQGGYPKSSHDEFNSRHGLSSNLSDAGIQQKLDEMRENLKKEIRKEMKIKEGAERLPLLEIKNFSFSSLFFSLFSLLFSFLFSLLFFLSSFLSSLFFSLFSLLFSLLSSFSLSLLFSLLFLSLFLSSLFLSSLFFFLSSLFSLFFSFSLFSFFSLLFFLSSLFSLSSFSLLFSLSLSSLLLSLSLFSFLSLLFFFLFSLSSLFFSLFSLFSFFFSFLFSSLFFSLFSLFSFLSSLFSLLFSLSSLSLSLSLLFFSLSLSLSSFFSFLSLLFSLSSLFSLFSFLSFSLSSLFSLLFSLFSLSSLFSLFSFLSSLFSLFSFLSLLFSLSSLFSLFSFLSLLFSLSSLFSLFSFLSLLFSLSSLFSLFSFLSLLSIVSIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AMQ6</accession>
    <name>A0A812AMQ6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_1743</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000049">
        <property type="protein sequence ID" value="CAE1146024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AMQ6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1146024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="157" mass="17988" checksum="DB326A03E8B5EF51" modified="2021-09-29" version="1">MLFDWRSKWPLDVDWSRLMTSFIIFSLALFRSHDGPELQNAEDIVPCRVDLGLSFFPIKLQQGLSQVDPTSSFLPYGHHQLLTSSFSLCLSSPPFFLSSTSQNTLSSNFIHPLFFLLSFLVIVVAVMIRSFALLFLLHYNSHSLPPPHGEREKHVFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812APF3</accession>
    <name>A0A812APF3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_2279</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000063">
        <property type="protein sequence ID" value="CAE1147908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812APF3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1147908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="233" mass="26056" checksum="E9CC8A90F037165E" modified="2021-09-29" version="1">MNIISRRKSCRSAVLAWCTSAWYEKRIIKQFALKSNTASLSLSLSLYLSTSLHPLSLPISLSRIGSLSLSLSLSLSPNLLSLSAFLTLVLSLSSHSDFLSVSPFLTLVLSLSLSPFPNLVLSLSLPTYTYIYIYIYISLLTLLLSLSFSLSLYLFIYLSICLSVCLSIYLSFSRPGSLCLIPSIYLSIYLSIYLSIYLSISISHSDSFAHELSIYLHRFAKNDHTMMKKKKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812APV3</accession>
    <name>A0A812APV3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_1746</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000049">
        <property type="protein sequence ID" value="CAE1146055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812APV3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1146055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="203" mass="24314" checksum="43B86CD4C700D293" modified="2021-09-29" version="1">MLFSSVVINSIHPPPATRALFVSAFPPYAPSLFASSLAYEQKRAFSFYLGPYSPPTPCSFFQSFIFSQIFFLIIYIFLYSQNFFFFFFFFFFFFFFFFFFFFFFKFLITSLLFLFHFLLFYFSFLSLSFVPFLIYFLFILSTSYIRLVRRRKQLNTALQRRANNYRNAVCTPFLSFFLSFFLSFFLSFFLFSLCIASPLADAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AR86</accession>
    <name>A0A812AR86_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_3533</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000106">
        <property type="protein sequence ID" value="CAE1152659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AR86"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1152659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="157" mass="16879" checksum="96C1A281D8DF05FB" modified="2021-09-29" version="1">MITLDITTLFTLALTLCNPSLFTLALTLCNPSLFTFALTLCNPSLTLALSLCNPSSLLLLSSLQPFLFLLLSSLLCNPSLFTLLSLSVTLPSLLLLSLSVPSSLLLLLLSVTLLFTLALLSVTPPLFYFALTLCNPSLFTFALLSVTIPSFFCSHSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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    <name>A0A812ARJ8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="2 3">
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        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
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            <authorList>
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                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000087">
        <property type="protein sequence ID" value="CAE1150717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ARJ8"/>
    <dbReference type="OrthoDB" id="10071251at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1150717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="153" mass="16774" checksum="A75DB3FEB80F6DC1" modified="2021-09-29" version="1">MLSVGDGITDNILKENLKDTACLLVDETRDTFDTTSASQTANSGLGDTLDAISEHLPRSLSLSLSLSLCLSVCLSVCLSEWVQLSLNPNVCLSLSLSLSLSLYLSIYLSIFYTAICQWLSFKKYIHLSLNSYAFFSLLPSPLSFSLIQQYANV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ASE7</accession>
    <name>A0A812ASE7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_3540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000106">
        <property type="protein sequence ID" value="CAE1152700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ASE7"/>
    <dbReference type="Proteomes" id="UP000597762">
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    </dbReference>
    <proteinExistence type="predicted"/>
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        </location>
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        <location>
            <begin position="591"/>
            <end position="609"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="641"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="667"/>
            <end position="688"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1152700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="689" mass="84206" checksum="6D48958E8AFCF95A" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ASZ7</accession>
    <name>A0A812ASZ7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_3291</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Spiralia</taxon>
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            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000097">
        <property type="protein sequence ID" value="CAE1151943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ASZ7"/>
    <dbReference type="Proteomes" id="UP000597762">
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="404" mass="47441" checksum="7397F45A279670AF" modified="2021-09-29" version="1">MEFKRKSVKEKALELKHCFYQFPHTDAHSSIIVFPLLSSKLYSVRPSVRPSVRPSVLPSFLPSFLPFCLLSFFCLFQYPVTYVFFLPSLSLSLSLSLIEFLSFSFPLRYLAHSYNLFFFHFLFRIVFLHSFFQIFSLFQYSVTIIILSRFLDLSPSHPPFPSLLLPFSPSLSFSLSLSLPLSLILSFSSPLSLSVATCLLEFSLLFLSFCSFFLFLSFTICISDLSFFLFASLTFPIFSYLRFPLLSLSLSANFIYFFLSFLLFFSLYTNFFHIFFRLHSSFFYFTIFNYSLPIFFSFSLFLSDFFLIQLPPFSLAILRLNIFSFLLFNYYLIWFSFFRSFGLSIFPSFFHFLSFFLSAVLSFLPFSFFLSFYFFFLSSCLVIVFLSLSLSFCLSFCFSFLLSF</sequence>
</entry>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">SPHA_6659</name>
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    <organism evidence="2 3">
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
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    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000218">
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    </dbReference>
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        </location>
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        <location>
            <begin position="641"/>
            <end position="667"/>
        </location>
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        <location>
            <begin position="806"/>
            <end position="825"/>
        </location>
    </feature>
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        <location>
            <begin position="845"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="882"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="908"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="934"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1000"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1028"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1058"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1087"/>
            <end position="1109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1161029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1123" mass="129939" checksum="33B388BB0ED2D3B6" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AZ17</accession>
    <name>A0A812AZ17_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_7696</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000247">
        <property type="protein sequence ID" value="CAE1163460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AZ17"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="295"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="324"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1163460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="350" mass="38751" checksum="9C32E1AE46FF1570" modified="2021-09-29" version="1">MISLSLSLFLPLSLLLLSLISLSLSHLTFSLSSHFLSLISLSLSHLTFSLSSHFLSLISLSLSHLTFSLSLSLSLSSLSPSLYHYHLSLPLFIIIISLSLSLSLSSLSPSLYHYHLSLPLFIIIISLSLSLSLYHYHQHFSFSNIFLFDTTFYFFLPLSPLITLFSNVSAVCLCVCLSLSLPNPYFVLGYYFSFLFYCFLISPPFSVISFSPPFSVISFSPPFSVISFSPPFSVISFCPPFSVISFCPPFSVISFCPPFSVISFCPPFSVISFCPPFSVISFCPPFSVISFCPPFSVISFCPPFSVISFCPPFSVISFCPPFSVISFLSSLFGDFVLSSFSVISFCPPFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B3K1</accession>
    <name>A0A812B3K1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_9574</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000306">
        <property type="protein sequence ID" value="CAE1167770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B3K1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="321"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="348"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="403"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="432"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="457"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="486"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="512"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1167770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="553" mass="65268" checksum="B44C24D875448A01" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B7B1</accession>
    <name>A0A812B7B1_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Sister chromatid cohesion protein DCC1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SPHA_12114</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Farmed</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DCC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000402">
        <property type="protein sequence ID" value="CAE1172382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B7B1"/>
    <dbReference type="OrthoDB" id="5199543at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034088">
        <property type="term" value="P:maintenance of mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019128">
        <property type="entry name" value="Dcc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13395:SF6">
        <property type="entry name" value="SISTER CHROMATID COHESION PROTEIN DCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13395">
        <property type="entry name" value="SISTER CHROMATID COHESION PROTEIN DCC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09724">
        <property type="entry name" value="Dcc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAE1172382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="403" mass="46118" checksum="C7AB72467AB05DED" modified="2021-09-29" version="1">MSSNLMSSNDQKEERTLEEVQRILEFAKLKISDIKPFTQCINFSEELDNEKLKLLEVDKKTLETLEAGKSLVIRGEKNNNAILCTDDKTFELKEAEMSNSLLVIPDCVFGSDISAEGCPKLSDLKVVSSLQTYYEMRPVRPKLEKLKLLLEKNQYSGQECEEDSEHQGPKFTTENLLDIVQASEKELSEGLKVMDALQIEGYWRLLEFDFLTQVLSHILQLAEEEDWLFAGVPVKSCCDVLGELYLRSVVEHVLRIYSEDTENSASDDELLKLSEDKICRFFAKLTIKNTGKFNLAEFIQVWKQCVPEGMTPNLRQLEGMALVNKNSKPEVISYFPVEELPQDIGQRFNILFQTQEKWTLTEITPYLKDLEGEKQNIGSMLLKFARASTQNGQKVFSSRHPIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B9M5</accession>
    <name>A0A812B9M5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_12723</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000424">
        <property type="protein sequence ID" value="CAE1173522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B9M5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1173522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="256" mass="30202" checksum="BC217D6F524B8667" modified="2021-09-29" version="1">MVTSSSVYLSIYLSIYLSIDLSISFSLSIYLSFGLCRSIYLSMSILWYLSIYLSIYQFSLLIYLSIYLSIYLIQSIYLSIYLSIYLSIYLSFGLCRFIYVDFVLSIYLSIYLSICQFSLLIYLSIYLSHSVYLSIFLFVYADLSIYLCRFCGIYLSIYLSIYLSIYVFFFFFFTVLWTVISKTPLSRAKRSYLSIYLSIYLSIYLSIYLSHSVHIYLSIYLSIYLSIYLSQSIYIYLSIYLSIYLSIYLSLSKSMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BD07</accession>
    <name>A0A812BD07_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_14368</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000491">
        <property type="protein sequence ID" value="CAE1176954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BD07"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1176954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="273" mass="33935" checksum="2C746EAACEA9AF92" modified="2021-09-29" version="1">MLISMYASYICMHLSFLRLFDSLFIYMFLHSFLPSCNPTILCQSSFYVPYILFHFLFFILSLSLFFLFFLLFLSFFSFFYLFLSFLSFFLSFFSFFLSFLSFFLFFLSFFLFFHSFFLSFFSFFLSFSSFFLLFVSFFSFFLLFVSFFSFFLLFFFLSFLPFFFLSFFSFFLSFSSFFLLFVSFFSFFLLFVSFFSFFYFFSFFLFFHSFFFLSFLSFFLLVLSFFDLFLSFLSFFSFFLLFVSFFSFFYFFSFFLSFLPFFFSFFLFFLSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BEQ1</accession>
    <name>A0A812BEQ1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_16017</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000559">
        <property type="protein sequence ID" value="CAE1226453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BEQ1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1226453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="311" mass="35162" checksum="E15B9C8A6C492CF4" modified="2021-09-29" version="1">MKKKGREEVDSSAGLNRWAAYLLAIRLSIYLSIYLSIYLSIYLCLSSIYPSISIYLSIYPSIYLHLSIHPSIHVYLSIHPSIHPSIHVPSASIYPSIYLSIYLSIYVSSVSIYPSIHLSIHLFMSLYLSIYLSIHVSSSIHLSIHPSMSLQYPSIYLSPSIYPCLFSIHLSIHPCLSISIYPSMSFSIHPSIHLSIYLSMSLQYLSIYLSIYLCLFSIYLSIYLSIYVSSVSIYLSMSICVSSESIYLSIYLSLFSTITNVSVEGGGKKYPYEVRYFLNCFSLSLSLSLSLSLSLESQKNMEGRKCSFIVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BHG2</accession>
    <name>A0A812BHG2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_16741</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000593">
        <property type="protein sequence ID" value="CAE1228286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BHG2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34723:SF7">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34723">
        <property type="entry name" value="PROTEIN CBG17025"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="316"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="349"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1228286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="472" mass="54973" checksum="0911456905EA2A92" modified="2021-09-29" version="1">MFLKISFFFLIFLPSFLSFFLFFFLSSSFLPSSQPSFLPFILLPSFLSSFLPFILLSSFLLSFLSFFLSFLPSFRPFFLPKLSFFLSFFLSFFLSSFLPSFLPSFLPSFLSFFFILSSFLPFFLFLLFFLPFKFLSSFHRSSFLSFFLSFFLSFFLSFFSLFLPFFLFPSFLPFFLSSFLPSFQPSFLPFILLPSFLLFFLPSFLSFFPSFFLPSFLPSFLPSFLPTFLPSFLPFFLSFFLSFFLSSFLPSFLPSFLPSFLLSFLPSFLPSFLLPSFLLSFLSFFLFLPFFLPFFLPSFQSSFLPFILLPFFHPSSFLPFFLPSFLSFFLSSFLPSFLLSFLSSFLPSFLLFSFLFFPFLSFSNASLYFSFFFLPTITSPSSQVLRRWTRSQATGVDALAIIVTTRSYGLGRHMDDDRPPPTKRDCSMASYPLASAHSLERKKLYKDTLKESLKRCGIAYCTWEESADDCVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BHH7</accession>
    <name>A0A812BHH7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_17644</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000631">
        <property type="protein sequence ID" value="CAE1230308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BHH7"/>
    <dbReference type="OrthoDB" id="10656974at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1230308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="302" mass="34669" checksum="A6608AAA3AE6D0FF" modified="2021-09-29" version="1">MTHLSFKSDCLKKTNFKLIQIPVDVLPPACIPFCCFLFSFVLSLNFFQNSLLISFSFLAFLSAMLFLFTSFILLTFFPLFSQIHLMLLTNSLSIAANLFTKSLFIAPYTFNKSLSIVTYSFTQPLSIAAYQFINHINRCILVHQIIIYVCILVHQIIVYGFIIVHDLSLKTNLPNHYLSLHTRPSLINHCLSLHTRSSIISNAAYSFINSLSTAAYSSSIIIYRCIIVHQIIIYRCILVHQIIIYRCILVHQIIIYRCIIVHQIIIYRCILVHQIIIYRCILFHKSLSTAAYSLIKSLSIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BIL4</accession>
    <name>A0A812BIL4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_19384</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000704">
        <property type="protein sequence ID" value="CAE1234438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BIL4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1234438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="262" mass="31169" checksum="3EC0F1AE22F6D0AA" modified="2021-09-29" version="1">MHMCCVHTYLSIYQPSSLALRLHISIYLSIYQPSSLTLSLHIYLSIYLSIYLSIYISLHIIYLYVCVSIYLSLYITVCTLSIYLSLSPYLSIYLFLSVHTNRSIYPFQSVHIYLSIYLSIYLSICLSKSTVIYLSIYLSIYLSITFSVTKPDLNHTGRSYLLQSFFLFSFFLIFTFFLSFSFFFLSLSFVLFLSLSLSFSLFFLSYIFFLFLFRFCFFFLSFSFFCFLLLSFFLSLFLSSFFYFHFLSFFGKHPELFLWLLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BIP7</accession>
    <name>A0A812BIP7_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Helitron helicase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_17401</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000620">
        <property type="protein sequence ID" value="CAE1229628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BIP7"/>
    <dbReference type="OrthoDB" id="6134515at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786:SF74">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786">
        <property type="entry name" value="DNA BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helitron helicase-like" evidence="2">
        <location>
            <begin position="275"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1229628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="457" mass="51461" checksum="7978586AF2A06555" modified="2021-09-29" version="1">MPPKRRKHLGRRTAADSAAGAARASEKPLNRLSQMASSSAARLSTESAAVRTESLASAASTMSARRARLSVEERSSQNSQDAVRVARNSRATAASRASERPQETAHRRFRNALSTASARALESPAQTTVHRVRNARSPASARALESPAQTTVRRVRNARSTASARAAENSEVRRQRVVIDADRRPHGEHERRFNAPVCNEIAAVIHGEEHNSRDIVIRYRGGGLRRISETHRSYDCLQYPLLFPYGSDGYHCRIPIYQGSSDSMSTSKTVSCRAYYAYMFMVREGEFNHLHRCRQLFLQFAVDMAAKMESERLGFIKLNQSKLRTDSYIHLRDGLRSAGNPHNLGKPCILHSSYTCGPPYMHEKTQDAMTYVCHYGRPDLFVTCNPKWVEITSEPFPGQQYSHCPDLIVRVFRLQLCKLMDLILKGQVFGRVKCHMYTVEWQKRGLPHAPHSAVAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BJJ3</accession>
    <name>A0A812BJJ3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_16736</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000593">
        <property type="protein sequence ID" value="CAE1228253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BJJ3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="349"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1228253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="382" mass="45354" checksum="B4967EC9747CBAF7" modified="2021-09-29" version="1">MSLLFFFFFFTRNIFFFFRLSFLYSYFSCFPSLIPYFPLALFLSLLPFFFLLPFFFFFAFLSFLPFFFLLPFFILIQYFFLFCSPFSFLFLFMSFLLFSLLFLLAPLFSLRFPFLFFLPFSPLLSVFLLVPLFSCSNFLSFLPFFSCSYFLSFLAFSPLPPLFSPSFCFSSCSPFFLFLFSPLPPLFSPSSPFLFLFPFSLLPPFFLFVPHFSPSSPFLFSLLPPRFSYCSYFLSFLTFSPLPPLFSPSSPFLFLFPFSLLPPFFSFCPSFLSFLPVPIFSPPSPFLPVLPFSLHSLLFFLFPFSLLTLLFCSCSPFSFAPHFFFLFPFSLLAALFRLASFFLSSTYLFYYLFFFFYLFLCFFFNLRLFFCLLQTTLFHFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BLL7</accession>
    <name>A0A812BLL7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_21063</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000775">
        <property type="protein sequence ID" value="CAE1238043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BLL7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="307"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="370"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="458"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="495"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="521"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="547"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="581"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="611"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="651"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="675"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1238043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="709" mass="85490" checksum="8E15104AC48969FF" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BNW2</accession>
    <name>A0A812BNW2_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Parvovirus non-structural protein 1 helicase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_19029</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000688">
        <property type="protein sequence ID" value="CAE1233597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BNW2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019079">
        <property type="term" value="P:viral genome replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001257">
        <property type="entry name" value="Parvovirus_NS1_helicase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01057">
        <property type="entry name" value="Parvo_NS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Parvovirus non-structural protein 1 helicase" evidence="2">
        <location>
            <begin position="2"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1233597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="231" mass="27667" checksum="318B6B4BD54E9A97" modified="2021-09-29" version="1">MIYTDEMWFTPQNVEEAKCILEGTETYVNVKHQNERLLRRTPFISTSNSEPWKVVLHEKEAILNRMYHYTTTRSMPRLEKWGKVELNPLMWLTVWKRHIDKYANNEYHEILTELEMDDDEPKQAKTLLYFIQWDGASPKKRRRLYRVKKTLAAQLQQEDERPGLPGCRFDDEQAAQVCAAHMRSMADCSAEYWKYYATPKNQTRKRRWKDNTESDDELLATEIDDTQTQEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BPQ1</accession>
    <name>A0A812BPQ1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_20522</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000751">
        <property type="protein sequence ID" value="CAE1237007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BPQ1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1237007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="269" mass="32913" checksum="5CDABF263EDA82C4" modified="2021-09-29" version="1">MIILIQCISCFFHPSLFRLLFFYSFFSSLAFKFILSFFRTLLFAFFSFYWSFLFLPLSLFCVVYIFFSFLFPCHLFLFLVHSFSFFLFFFLFSFFLFLTSNYFPCFFPPFLFFFSFCLFYFLPFSLFGSLQLFPFFLSQVTFFFSSSIFFLSCSFFFFPFYMCFFLFSFFLFGVYNSHVSLFLSMFQYSVLVILSFGIITFFFLTFVHSSFFSFSYSNSLSFFLSFFLSFFLSFFLIPIIIISVLFSFNSLYHFFLYIYSFFFYFKCYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BRD5</accession>
    <name>A0A812BRD5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_21475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000788">
        <property type="protein sequence ID" value="CAE1238781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BRD5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1238781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="192" mass="21806" checksum="B3C8304EDC128F72" modified="2021-09-29" version="1">MICKNVKSREMAEDDFSIFISISASSNLSVSSYLSVDLSTHLSILVASYLSIFLSIYLSIYLSLIISIYLSIYLSIYLSIYRSISLSIYIYLSLSTSICLSIYPSIYLSISISSIYLSIYLLQSSPLKVDSVVKIEAVFLMNSFPNKIVRTNYIYLSIYLSIYLSIYLSIYLSVFLSFSLTFSLSLTHTQHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BRZ8</accession>
    <name>A0A812BRZ8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_25770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000977">
        <property type="protein sequence ID" value="CAE1247658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BRZ8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1247658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="222" mass="24296" checksum="E51BF4343F2AC89A" modified="2021-09-29" version="1">MSVCLSVCLSLSLSLSLSLSLSLFRLVLKYWIYEPSVKEVVGGKNITFYSLRGLWERQNQILKYKISGKEGYLDVGNKFANHKFKPGSLDSWFDAVRSLEVIGALINLGSMGTAIFWYIFANKLDYMETTSRLTFVSLIVAGILDLLGVTIMIGKVDPQLTSWGGTLCEVMLALSLSLSLSLSLSLSFSLSLYLSLSLSLSLSLSLSLSLSLSFSGGNHFGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BSB4</accession>
    <name>A0A812BSB4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_23080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000856">
        <property type="protein sequence ID" value="CAE1241968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BSB4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="311"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="342"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="381"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="410"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="436"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="470"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="500"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1241968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="576" mass="70227" checksum="07D70CEE145EC89C" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BU22</accession>
    <name>A0A812BU22_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_24045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000891">
        <property type="protein sequence ID" value="CAE1243856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BU22"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1243856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="217" mass="24977" checksum="10D63EAECBFEE107" modified="2021-09-29" version="1">MSFFISFFISFFFLSFFLSFFFFFFFLSFCLSFLQIFNFSLFVFPLSFCRLAIFFLSKIILCSFSFISRLFLLTFNTTFSLKCRSLFIYFFISFFLLSFFLFSNSYSLIFLHSHYLCYRSFSFRSFFFSSSILLILPLFTLTTITALILSAASSPTTTSYLLLLSLSSNSPLDSVALLCDVITHLSIYLSIYLSIYLSIPFIQSSSSSSSSSSSSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BV88</accession>
    <name>A0A812BV88_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_24270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000904">
        <property type="protein sequence ID" value="CAE1244370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BV88"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032802357" description="Secreted protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1244370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="265" mass="29735" checksum="F8C6B7F0882ECE82" modified="2021-09-29" version="1">MSIRSRNSSLLIICSMTLSLSFPRQRKVYSFPHKTFPTVEAACLLKLCNLHSKPNAAISIRSRNSSLLITCSLTSSLPFPARRKCTLSLMKDSPTVEAACLLKRCNVHSKPKYAAMSIQSRNSSLLIACSLTSSMPFPARRKCTLSLTKYSRLWKTACLLKRCNVHSKPKYAAMSIRSQNSSLLIICSLTSSLPFPRQKKSVLSPHERFPTVEAACLLKRCNVHSKQKLFVVNHLLFDIVLPVSPPEECVLPLMKDSRLWKPRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BX28</accession>
    <name>A0A812BX28_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_27072</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001040">
        <property type="protein sequence ID" value="CAE1250401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BX28"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="319"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="425"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="460"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1250401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="488" mass="59980" checksum="280DEDAFEA2202C6" modified="2021-09-29" version="1">MLSFNIVWYKIICFGEHPLVHLIPFPFISLYFLSFHLLFFSVKLLSPFFLSFFFLYCFSLLSFFLSFFLSFFLSFFLVFPCFSLLSFFLSFFLSFFFLVFPFFLSFFLSFFFVFPCFYLFSFFLSFFLSFFLYCFSLFFPSFFLSFFLVCFSLFFPSFFLSFFLSFFLSFFLSFFPSCLHHDIDFSSFVISRLYYLSFFLSFFLSFFLSCLLLTFFFSFSFFFFFSFLSFFLSFFFLSFFLSFFLSFFLSFFPAFTMTLISLHSLFHVSIIFLSFFSFFFFLFFFFCFFPCFSFFLFLSFFLSFFPCFSVFLSFFLSFFFFFLFFFLVFPFFFFLSFFLSCFSLLSFFLSFFSFFPSFFLSFSFLSFLFFTVFFLFDFFYFLNSFLFVFLFFRCCCFLICLFLLLDFSFHCFFNFLIVCFNQFSLSFLSLFICVFLLFRLLTFLSFFFAFIIFTSAFTLFSFFCLFLFTFPFIFAFNLFSPFVYFPFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BXP0</accession>
    <name>A0A812BXP0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">OLFR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_24572</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000918">
        <property type="protein sequence ID" value="CAE1245022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BXP0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="313"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="385"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="424"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="474"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1245022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="521" mass="56666" checksum="61EADD897367B82F" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BZ45</accession>
    <name>A0A812BZ45_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_26719</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001020">
        <property type="protein sequence ID" value="CAE1249692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BZ45"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1249692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="156" mass="18071" checksum="6154510D5FED9DC7" modified="2021-09-29" version="1">MYLSIYLSIYLSIYLSIYQFVVLCHGLILNKIVWPTMTAVSVMLDFQHNTNEMRHLLHLISLTIFSHLLLFLFSFIIACPLIFRHSPYFSQRHLLVTPTFPVALFRYTCMQHNSLPITNGCWRSDFTVVISRRYSTGSASTEGERRAAAINSPNYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BZS9</accession>
    <name>A0A812BZS9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_25900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000986">
        <property type="protein sequence ID" value="CAE1247919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BZS9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1247919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="279" mass="33658" checksum="379DCAB419CE5F19" modified="2021-09-29" version="1">MLPLNPHPHPHSLSFCALHISLLLSLSFTLSLSLSHTHTNTHTFSFSNVAIQETYTYAYMHKYLSIYLSIYLSIYLSIYLSIYLLMFDLSINLSIYLSISLSLSLYIYIYIYIYISVNSLTYFIFFFFILLTFLLFFFFVSFFFFSHSFFFIFPFRFVSPLFLFFLYNLFSFLNFSIYFSLLFYFSFLSFSFFSFFFLFSFLQFSLFSFFIPSPLSIFFSLSPLFLFCFSYLFSFVLVLSFSFLFLFLFSLGFVFFLSSVFFSFYLFCLFFFYFPFSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C1S6</accession>
    <name>A0A812C1S6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_28059</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001104">
        <property type="protein sequence ID" value="CAE1252625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C1S6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="282"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="318"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="347"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1252625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="378" mass="45060" checksum="A264312D539AEF23" modified="2021-09-29" version="1">MAAISFFIHGSHILFLFMAAISFFHLWQAYPFFIYGRHILFLFIAAISFFSFMAAISIFIHGSHILFHSWQAYPFSFMAAISFFIHSWQPISIFIHFFIYGSHILFFHSSHSFMQPYPFFIHLYPFFFILFFIHGSHILFFFIHSSHILFSFIHSSHILFSFMAAISFFIHGSHILFSFMAAISFFIHGSHILFSFMAAISFFHLFSFFFIYVSHILFHSWQPYPFSFMAAISFFFYFISFFFIYILFYSWQPAIYPFFSFMAAISFFIHGSHILFYYSSHILFFFIYGMASHIHFHFGISFFLFMQPYPFSFIHSSHILFFMAAISFSFMAAISIFIYAISFFYSFIFFIYGSISFFFFMAAISFFLFIAAISFFHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C1U2</accession>
    <name>A0A812C1U2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CNPY3_4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SPHA_26941</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Farmed</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the canopy family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001031">
        <property type="protein sequence ID" value="CAE1250075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C1U2"/>
    <dbReference type="OrthoDB" id="6020060at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021852">
        <property type="entry name" value="DUF3456"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15382:SF8">
        <property type="entry name" value="CANOPY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15382">
        <property type="entry name" value="CTG4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11938">
        <property type="entry name" value="DUF3456"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032401535" evidence="3">
        <location>
            <begin position="22"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3456" evidence="4">
        <location>
            <begin position="30"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAE1250075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="218" mass="25403" checksum="14178E1C4EFA488A" modified="2021-09-29" version="1">MNLSNFFFLICLLYTIIIYQSSQVTLPTLCEVCKYMTLELQEKLAETEKSKAVLETGQGLDKKKRIQYQFSELRLTEALHEPHVCDRLLKYNIHNEKPGSLRYAKGRSETMQTLHGLRMKGVKVDLGIPEDLWDTPSVEVSDLHRKCIRLVEDHETDIEDWYFSHQGRRSLQEYLCKDIVLLSHEADCLYEKESNSNKINEEKKYLKGEITGGTKIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C4N0</accession>
    <name>A0A812C4N0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_29519</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001177">
        <property type="protein sequence ID" value="CAE1255388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C4N0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1255388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="217" mass="25851" checksum="E3D459E3AD9289C4" modified="2021-09-29" version="1">MFVSIYLSIYLSIYLSIYLSIHTHRHRHTHIYIYIYFACIYVGAKIMCFLRSTTSKTTLFLLQPNIYLSIYLSIYLSIYLSIPAYYLFIHLFILLSSYLSIYLHIYLSIYLSIYLSIYLIYYIFIYLFIYPIIYLSIYLFIYLFILLSSYLSIYLSIYLSIYLSIYLNQYHFILICLRSCTQGQDDPGVAAQQSSSPLVAEILPAFPPDFKHLVYFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C766</accession>
    <name>A0A812C766_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_28923</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001143">
        <property type="protein sequence ID" value="CAE1254388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C766"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1254388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="204" mass="24060" checksum="CA9B26E9583D683C" modified="2021-09-29" version="1">MPLEATLRHQCANWCHRRRTYSSVVHVCFEGLHAFSSIFTMAEKDACRKLKEHLEIDPDLFFFFSSPVTKFVAMATTRKRSSNQVSGSIQRHHNPTKKRVNDLSIYLSIYLSIYLSLYIYFFSIFVKFSIFQDVKTLLLTIRLSFFLSFFLSFFLSFFLSFFLSSFILSFFLSFFLSFILSFFLSLAEGKQRLFLSFQGIIHYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C7I3</accession>
    <name>A0A812C7I3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_30950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001251">
        <property type="protein sequence ID" value="CAE1257820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C7I3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <begin position="124"/>
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        <location>
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            <begin position="312"/>
            <end position="330"/>
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        <location>
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        <location>
            <begin position="426"/>
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        <location>
            <begin position="457"/>
            <end position="477"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="484"/>
            <end position="506"/>
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    </feature>
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        <location>
            <begin position="526"/>
            <end position="551"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="563"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="595"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1257820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="662" mass="78107" checksum="299D1DA4EAAF388D" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C958</accession>
    <name>A0A812C958_ACAPH</name>
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        <submittedName>
            <fullName evidence="8">DeoA</fullName>
            <ecNumber evidence="8">2.4.2.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SPHA_31716</name>
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    <organism evidence="8 9">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
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    <reference evidence="8" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Farmed</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:cytosol"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004645">
        <property type="term" value="F:1,4-alpha-oligoglucan phosphorylase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009032">
        <property type="term" value="F:thymidine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006206">
        <property type="term" value="P:pyrimidine nucleobase metabolic process"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006213">
        <property type="term" value="P:pyrimidine nucleoside metabolic process"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1030.10:FF:000003">
        <property type="entry name" value="Pyrimidine-nucleoside phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1030.10">
        <property type="entry name" value="Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.30">
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    </dbReference>
    <dbReference type="Gene3D" id="1.20.970.10">
        <property type="entry name" value="Transferase, Pyrimidine Nucleoside Phosphorylase, Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
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        <property type="entry name" value="Glycosyl_Trfase_fam3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017459">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom"/>
    </dbReference>
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        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035902">
        <property type="entry name" value="Nuc_phospho_transferase"/>
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    <dbReference type="InterPro" id="IPR036566">
        <property type="entry name" value="PYNP-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000053">
        <property type="entry name" value="Thymidine/pyrmidine_PPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004490">
        <property type="entry name" value="PRK05820.1"/>
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    </dbReference>
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        <property type="entry name" value="THYMIDINE PHOSPHORYLASE"/>
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    </dbReference>
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        <property type="entry name" value="THYMIDINE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glycos_trans_3N"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52418">
        <property type="entry name" value="Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain"/>
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    </dbReference>
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        <property type="entry name" value="Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain"/>
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    </dbReference>
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        <property type="entry name" value="Pyrimidine nucleoside phosphorylase C-terminal domain"/>
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    </dbReference>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 3" evidence="6">
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    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="232"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAE1259501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="730" mass="80939" checksum="0D1FE91719416C8B" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CAH9</accession>
    <name>A0A812CAH9_ACAPH</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_29950</name>
    </gene>
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        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
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            <taxon>Eukaryota</taxon>
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            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001202">
        <property type="protein sequence ID" value="CAE1255993.1"/>
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    </dbReference>
    <dbReference type="OrthoDB" id="10690098at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="607"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="638"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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            <end position="708"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="714"/>
            <end position="738"/>
        </location>
    </feature>
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        <location>
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            <end position="770"/>
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    </feature>
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        <location>
            <begin position="776"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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    </feature>
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        <location>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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        <location>
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        </location>
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        <location>
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        <location>
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    <feature type="transmembrane region" description="Helical" evidence="2">
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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            <end position="1687"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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        <location>
            <begin position="1737"/>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        <location>
            <begin position="1943"/>
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        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="232"/>
            <end position="246"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="253"/>
            <end position="264"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1985"/>
            <end position="1999"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1255993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="2064" mass="234583" checksum="052F7752A36799CE" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CAR0</accession>
    <name>A0A812CAR0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_31649</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001304">
        <property type="protein sequence ID" value="CAE1259334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CAR0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032287945" evidence="2">
        <location>
            <begin position="19"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1259334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="347" mass="40161" checksum="9D0F242095373A31" modified="2021-09-29" version="1">MKISLSVLICLPICFCFCQSPHISFSLCSYLSQFTVFVSVSQYLSIIYLSIYLSIYLSIYPSLFISIYLSIYLSIYLSIYLCRCLSPSSHIDIEVTPFLSLSLYIYLSVDQCEYLSKYFSRINKGLHSLWRIQSRTNRWYGTLLCTGQRIQQTPNNTPNERTIEKHCYDDVNRVRRHVVVYGPVFLGILAEGSRVAVEAGAMLIGMVVEEEEGGVTIYLSLSAHIHLSIYLSIYLSIYLSIHLSIYLSILYYLLLFSCCLSIYLSIYLTIYLSISVSSYLSIYLSIYLSIYLSIYLCYYRQIYLSIYLSIYLSIPVSSYLSIYLSIYLSIYLSIYLSIYLSQLRSIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CCN5</accession>
    <name>A0A812CCN5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_32849</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001369">
        <property type="protein sequence ID" value="CAE1261502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CCN5"/>
    <dbReference type="OrthoDB" id="6157510at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040350">
        <property type="entry name" value="TMEM272"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33444">
        <property type="entry name" value="SI:DKEY-19B23.12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33444:SF7">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 272"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1261502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="337" mass="38547" checksum="D07FE8F7EBE5950C" modified="2021-09-29" version="1">MALLPYLLLSESNSYNDDTTLYKTTVDWTASRVSVQSNYEAVFVQIKEATKEAESSWDFLCRSLHILTSTRESNHRQFSHTLSLSLSLSLSLSLSLFHHLSLSSTFSLFISFSLPLTFFFSSCHNLFCVFFLPPCFSRLLFPSLSLSFSFRHNLSCVVTLPPWFYTLLLAVSTALPMAMMTAGVKYLHDCPKQPKIPVYLLVGGCFGMLKLIYTVWYQIQQRRYDSLPDLVGLDPADRLAFTSRSYRLMDSLLIIFLVSWLCTGTYWVFDIWKPNFEQQLHDPNNWCSKTVYCLAAFQILGCFCWAGITVIVLIGLLIAYKCRQSRATKQTPTTNNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CD04</accession>
    <name>A0A812CD04_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_33759</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001419">
        <property type="protein sequence ID" value="CAE1263562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CD04"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1263562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="168" mass="19177" checksum="D118005E7A3A418A" modified="2021-09-29" version="1">MVMVASPIGVRTLSEGCMYDVRCVGGTTGVTDPTLPVCLPACLPACLSIYLSIYLSILSIYLSYLVIEILLRCSYRQQEQKNRLDRYEDIAHCLHGLLFLSYRIYLSIYLSIYLSIYLSIYLCLHICLTCICTHIIFCVNSSFLSRCVISCRQESIFINLKLFLKKII</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CH03</accession>
    <name>A0A812CH03_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_35129</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001510">
        <property type="protein sequence ID" value="CAE1266318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CH03"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1266318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="285" mass="33777" checksum="ECE5C09250D74ADE" modified="2021-09-29" version="1">MRRVLKRKHSEDILPNIVLALGFLETYNLFIYLSIYQYYLSPFISIYLSIYLSIPLSLTFSLSLSLSLSVYIYLSIYLSIYLSIYLSIYLNLSITAHLLLSIYLSIYLSIYLSICLSMLTICSYLSIYLSIYLSIYQSVHYLSKFVQICLSIHLSMYLSQSLSELLQIYLPTYVSIYLYVSTYSYLSIYLSIYLSISAPTNLSRVHIYISISPIYIYLSIYFSLFISIYLSEPQTNLSIYVFQPIHFYRSIYYLSHYVHIYLYIYLSFFIIYFSIYLNLFRSIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CJB5</accession>
    <name>A0A812CJB5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_34763</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001480">
        <property type="protein sequence ID" value="CAE1265564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CJB5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1265564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="197" mass="22553" checksum="EC1F506CCD4AE8BC" modified="2021-09-29" version="1">MGPAHQSISIKLPFPENVPIINPASLPLVSVNVTQTEVMIETTVRLAPSMFQALFLPSLRTFLFLSQSFLHTLSLLFSTFFSLNLSHSLSLSLSLSLFHLFIFTFSIFLLVFYFTLFLSFSFSDPYSYLILFSLPFIFIYIYLSIYLSLFLSLYLLVFLILISLRVHSLFIFFILFPKPLSIALSLSSYLSLSHTHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CMD4</accession>
    <name>A0A812CMD4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_38651</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001767">
        <property type="protein sequence ID" value="CAE1274143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CMD4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="331"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="387"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="419"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="478"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="517"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="547"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="579"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1274143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="600" mass="71612" checksum="BB99BC6B2A252AFA" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CPK4</accession>
    <name>A0A812CPK4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_41072</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001964">
        <property type="protein sequence ID" value="CAE1278131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CPK4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="313"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="347"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="378"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="403"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="438"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1278131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="459" mass="55451" checksum="3B50128196A2D135" modified="2021-09-29" version="1">MASVQPFPSNRELFFHFFSFSYPPFFPSTSLHLQNFYCHHFFSFFFSVLCIYFFFLSFVNLIFSTFSLVFFPVFLSFSLFLSLFLFFICFLLFLLLSILITYFFPSFLSDLFFLSFPFPLFLSHLLFILFSLLSLSFHFPFIFLAFSSTFLFLPFLFLFLSSFLFLLLSLLFLLFIPSCFICFFPFFPFSLIFIVFSFRYLFFSSFSILTFALFLFFPVFILFHFIFNIPIYFLFLLFLLFLYIYPIFLLILILFSLPFLSFSLFLLFLFFCYLSFFPLSFFFPVFFSLFLSFTFSSFFSEHFFPVSFFFSHYYILLFYWHFSFLFSLLFSSFFLPSFFFSVSFPSFSVSVLFFFFFFSFPLIFLIFIFHLILFSFSFLSPLLSFFTLFTVSFFLFSHHNFALFLLFFLLFSSSLSQSFFFIIFSLFLTFDILLSNHFLNYLSFFCLSSPLSYIIIPHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CQK5</accession>
    <name>A0A812CQK5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATPeAF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SPHA_41614</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002005">
        <property type="protein sequence ID" value="CAE1279097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CQK5"/>
    <dbReference type="OrthoDB" id="5673at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3580.10">
        <property type="entry name" value="ATP12 ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2180.10">
        <property type="entry name" value="ATP12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011419">
        <property type="entry name" value="ATP12_ATP_synth-F1-assembly"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042272">
        <property type="entry name" value="ATP12_ATP_synth-F1-assembly_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023335">
        <property type="entry name" value="ATP12_ortho_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21013:SF10">
        <property type="entry name" value="ATP SYNTHASE MITOCHONDRIAL F1 COMPLEX ASSEMBLY FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21013">
        <property type="entry name" value="ATP SYNTHASE MITOCHONDRIAL F1 COMPLEX ASSEMBLY FACTOR 2/ATP12 PROTEIN, MITOCHONDRIAL PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07542">
        <property type="entry name" value="ATP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160909">
        <property type="entry name" value="ATP12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAE1279097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="164" mass="18862" checksum="B8BA83618DBE2A2E" modified="2021-09-29" version="1">MAAVKNVVAGAVLRQVRSLFSASASSHFTTVPIARKIHTREVKKFYKNARIAQSNGLFEINLDKRKLRTPLGNLFQVDNESLALAVATEWNAQEDTIKQHNMYLTTLCNTVIDNPMQRTKEDLTKAVLHFLETDTLCYRMLDPPDLITFQQTHWDPLVDWFRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CQN7</accession>
    <name>A0A812CQN7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">LIPA</fullName>
            <ecNumber evidence="1">3.1.1.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_39207</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.13" evidence="1"/>
    <dbReference type="EMBL" id="CAHIKZ030001810">
        <property type="protein sequence ID" value="CAE1275017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CQN7"/>
    <dbReference type="OrthoDB" id="9974421at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004771">
        <property type="term" value="F:sterol ester esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11005">
        <property type="entry name" value="LYSOSOMAL ACID LIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1275017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="209" mass="24143" checksum="35638D779DFBCAC9" modified="2021-09-29" version="1">MIALGPVFTVGHMTSPVKLFTLFTDKKLFHIFGEKCFLSENKYIKLMAKTICKNPETRFICLDVIQLIAGFDQTHLNVSRLPVYLTHCPAGTSTRNMDHFAQNFRTKTCSKFDFGSKEENELHYHQPFPPQYNVTQMDVPVALYSGGKDSLADPQDVKILAKQLKNLVLHKCIEEWAHLEFIWGIDEILKDFRSIQFLCEKEHKLPNHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CR11</accession>
    <name>A0A812CR11_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AKAP1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_40151</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001892">
        <property type="protein sequence ID" value="CAE1276648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CR11"/>
    <dbReference type="OrthoDB" id="10069557at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd22395">
        <property type="entry name" value="KH-I_AKAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20407">
        <property type="entry name" value="Tudor_AKAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047368">
        <property type="entry name" value="KH-I_AKAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047367">
        <property type="entry name" value="Tudor_AKAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050621">
        <property type="entry name" value="Tudor_domain_containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22948:SF65">
        <property type="entry name" value="A-KINASE ANCHORING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22948">
        <property type="entry name" value="TUDOR DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00567">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50304">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Tudor" evidence="2">
        <location>
            <begin position="179"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1276648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="280" mass="31014" checksum="A2C13149C62BA05C" modified="2021-09-29" version="1">MGSRRTVSFVHVYRDRIEILTTLTSAQSTEELCGRLIGRQGKNIIHIKERSGASVSLQPSPYTPNHQICSIEGTQEEIDEALKCISQKFPNSIYPNVDLTAITDSTQLASSPMVVPDLIQLSLPPEGVSIDILVASLVDGGHLFLQLPTHPTYAALDRLNQFMNRCYSQPGMVPQLPRPLIVGVICAAPVMEGWYRAVIVAVSEETDECEIKFVDYGGFSQVPGNLLRQIRSDFMTLPFQAIEVYLANITPLQNIECAFFSECNIISHHFPLSQLLSIPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CRX9</accession>
    <name>A0A812CRX9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_41039</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001958">
        <property type="protein sequence ID" value="CAE1278079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CRX9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="316"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1278079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="345" mass="38799" checksum="1359807C4A8B39AA" modified="2021-09-29" version="1">MCIHELTVRPKEKKRSLSTSLFCHLSFFSSLSYQFSLFPPLSLSTSHSFHLSLTNSLSFHLSLFPPLSLSTSHSFHLSYQFSLFHLSLFPPLSLFHLSLFPPLILFISLLQFSLFPPLSLSTSHSFHLSLTNSLSYQFSLFPPLILFISLLPILSLSTSLSFHLSLFPPLILFISLLPILSLSTSLFPPLLFSPSHSFHLSLTNSLLPILKNISHSFSSLFPLLSFHLSLFPPLSLSTSLSFHLSFFSSLSYQFSLSTSLSLSTSHSFHLSLTNSLFFHLSFFSSLSYQFSLFPPLSFSTSHSFHLSLTTSLSFHLSLSTFPAFHPSVIACILIYISVFFKQTIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CTD5</accession>
    <name>A0A812CTD5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_41724</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002013">
        <property type="protein sequence ID" value="CAE1279287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CTD5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1279287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="201" mass="22953" checksum="7BA79F9F241D3A78" modified="2021-09-29" version="1">MSLPALPLHVSPGAFATCLYLQLGPLFVIKVRLLICPYSSLAPSLSLFFGNYLSLHIRSLFDHKSSSPYLLRLPEPSLLNPALSFLLKFFISLVISSFLAFHPRHIFPNSSAICFSLLFRGIFSVVFRYIFVTSLPHHICLSAICLYFKNFDVPLNSLSISLSLSLSLSLSIYLYLSIYNINFIYWMVERKQIFNIFNIIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CUB4</accession>
    <name>A0A812CUB4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_43610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002200">
        <property type="protein sequence ID" value="CAE1282706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CUB4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1282706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="217" mass="25643" checksum="2A4FF83780506BB8" modified="2021-09-29" version="1">MVRLCNKSLKWWLVFDFSLIFLTFFSFIVQSIQLLSFFLSFFLSFVVFISSFVDFSLKLDSLPLFSSFSCFFIISFFLSSLFLYAFPFTFIILHFLLDSYLFFRFLFSLIFFFFYFVQSSCAFSLTLNCISFPRLSLHFSFLFACIPRALSIYLSIYLSIYLSLNPKNEDKIACNPITYAQLKQIKQNLLPTHLSIYLSIYLSKFNSIVYLSIYLSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CVY4</accession>
    <name>A0A812CVY4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_45829</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002386">
        <property type="protein sequence ID" value="CAE1286148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CVY4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1286148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="215" mass="24735" checksum="4E02E213C3D53D7C" modified="2021-09-29" version="1">MDKDGHSDTVSWDGKQIWLAAVGCIIVAHVSSTISSVMRKEDSIYLSIYLSISIYLSIYLFVCRSHGFKWIFIAGNIFIYLSIYLSIYLSIYLSQFLLLVILSIYLSIYLSIYLSIYIYLSQVRAHKVSLQLRLLNAQHFASLLPKQLLCEAEQTLCDWQPSDWLDFLCPRLISIAARNLRISFLNDRMVPRRRLTCTGVKGLAFISFKPNLMTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CWL2</accession>
    <name>A0A812CWL2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NEBL1_2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_41836</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002023">
        <property type="protein sequence ID" value="CAE1279537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CWL2"/>
    <dbReference type="OrthoDB" id="6155897at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050865">
        <property type="entry name" value="BEACH_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031570">
        <property type="entry name" value="NBEA/BDCP_DUF4704"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743:SF112">
        <property type="entry name" value="BEACH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743">
        <property type="entry name" value="BEIGE/BEACH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15787">
        <property type="entry name" value="DUF4704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4704" evidence="1">
        <location>
            <begin position="171"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF15787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1279537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="305" mass="33659" checksum="2C04CA8F772D75B3" modified="2021-09-29" version="1">MIYVDGYMYLNAQLKFPTTTEPFTSCKVGAANQRSTIDLLLDMNPVSPTIPERKKSSPLKFFNFNSSPKSNCQSGVTTLPGGTQDDIWGQPIALMGQLGSVCVFYEALQPTEIKCLNSFGPNYSNLLTEDGELSDLPGKLLLYYNAKACKDGFCTDLSNNQNHGQLHGFKCVTWDIKDLLSCVGGIPILFPLLELVDKCQPILNESADITPLCERKPMISNDTTELEEDWIVVQSASSAESKLEQNQVAAFLTLLRNMLQTKVTNQDCFIRTHSAATIGALLQKVCIYRLTLFSTVSIQASHFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CXN2</accession>
    <name>A0A812CXN2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_43373</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002173">
        <property type="protein sequence ID" value="CAE1282300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CXN2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="334"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="358"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="396"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="432"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="475"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="501"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1282300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="525" mass="62251" checksum="ED750EC3997E7B63" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D0J5</accession>
    <name>A0A812D0J5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_47182</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002545">
        <property type="protein sequence ID" value="CAE1288523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D0J5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1288523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="320" mass="39885" checksum="25A925A598EE0BD7" modified="2021-09-29" version="1">MCCFLSIHSFIHHFSFFFLSIHSFINNFSFFFLSIHSFIHHFSYFFSFNSFFHSSFFLLFFFQFILSFIIFPTFLSFNSFFHSSFFLLFSFNSFIIFPTFFFQFILSFIIFPTFFLSIHSFIHHFSYFSFFQFILSFIIFPTFLSFNSFFHSSFFLLFFFQFIHHFSYFSFFQFILSFIIFPYFFLFSFILSFIIFPFFFSFNSFFHSSFFLLFFLSIHSFIHHFSFFFSFNSFFHSSFFLLYFLSIHSFIHHFSFFFSFNSFFQFILLFFIFYLFFLSIHSFFHSLFPSFLSFNSFFRSLLVFFFSFLLFKRRKERKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D1N7</accession>
    <name>A0A812D1N7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_44229</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002247">
        <property type="protein sequence ID" value="CAE1283722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D1N7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1283722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="204" mass="23879" checksum="9C93AE06A6D93EB1" modified="2021-09-29" version="1">MQKDFCFLFYKARREDINEQSKYLMRRSESTTQAHMHKKLVLNRWTGWAAEFDTFLFFSTPLFLSLLLSFSSHDYIILSHTVIYFSLFSDFFLTLYQRLFPLPVLSFKRNTFSLFLLFFPLFSLHRTHHLTKIETVTAFSCMNRHTYIPETSRRFLTGLGGAGSPVKSTKPSSCRDQQSPAPLRRSTDVPRLFQHPLTTLSSAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D2C8</accession>
    <name>A0A812D2C8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_44790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002290">
        <property type="protein sequence ID" value="CAE1284463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D2C8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="152"/>
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        <location>
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            <end position="185"/>
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            <end position="213"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="437"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1284463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="467" mass="55060" checksum="582947AA2E31A2E1" modified="2021-09-29" version="1">MGRNLPPSSPLPSSPRFPSRLTLASPLPCPHPTTHSRLNEFLSSFHPAFFSPHASCPLFFSFSPTNSARTFLKQSSYFPYYFSSAFLFSFSFITTRFLLYIHFSSLTLGFFSVSINFFIFSLSDTSFFLFLSSFSFIHIRFFFLLLLYFFFFSINWTTTKIERSFALIFFSFFSVLYYFFLSFYVSIFPSFYFTLFLISILNSFFIFYTLFLFDSLFFLSYTLSFFVFYTLSFFRLLYSSFLSILYSTFLSRPLQYSNNNCLSSDNLTPAYTSTSILYIYLPRCLFYLSIYLSIYLSIYLSIYLSISFLYLFIAVIISISVFYLSIYLSFYLSIYLSIYLSQSLYLISIFLSHDYIYLVFSIYLSIYLSIYLFNIYLSISVFLYYLVFIYLSVIISISVFYLSIYLSIYLSIASLYLSISVFISIYLSIYLSIYLSIYLNFSLSFYLGVSASYHLSIRNYQKLQTTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D2U0</accession>
    <name>A0A812D2U0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_49007</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002777">
        <property type="protein sequence ID" value="CAE1291922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D2U0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="37"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1291922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="187" mass="22096" checksum="20ADF88E84B802DE" modified="2021-09-29" version="1">MANVIGNHASIFRSFDVETLRSNIRPLIPTERPYKSIIIIFFLSFFLSFFLSFFLSIFLSFYLKGCLLLFPHSFSSLASCSLDYILLLFLQLFLLILPFLFVVAVIVVIVVLHHHHHHHHHHHHHHRRRLLLLLLLLLLLLLLPTSHFSGDFTVHISFAFFFVCKQNSDNFATEMMNDISRRYQHNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D8Q3</accession>
    <name>A0A812D8Q3_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SSD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_48159</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002655">
        <property type="protein sequence ID" value="CAE1290285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D8Q3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
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            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        </location>
    </feature>
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        </location>
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        </location>
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        <location>
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        <location>
            <begin position="651"/>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="707"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="2">
        <location>
            <begin position="483"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1290285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="727" mass="90184" checksum="FAF4CA55A2B99FDE" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D8R9</accession>
    <name>A0A812D8R9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_48177</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002655">
        <property type="protein sequence ID" value="CAE1290325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D8R9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1290325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="157" mass="18647" checksum="D02FFE4F41B3C6D3" modified="2021-09-29" version="1">MLPFFLSFFLSFFLICSVHYLSIYLSIYLSIYLFNLSIYLSIYLSIYLSQSVHYLSTYISIYLSQSVLSIYLSHSILYRSLSIYLSIYLSIYLSIYLSQSVHYLSTYISIYLSQSVLSIYLSISFYSLSIFVHIYQSIFRPIKYTNKAKHFFMYLPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D8Y8</accession>
    <name>A0A812D8Y8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_49654</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002867">
        <property type="protein sequence ID" value="CAE1293162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D8Y8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1293162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="161" mass="20478" checksum="E52E7A726786FE96" modified="2021-09-29" version="1">MLFSLFFHSFFILFVLFSSFFILFSFIFSSFFILSFFHSFFHHFSFFFILFSSFFTSFFILFSFIFSFFFHPFSFFFHHFFILFYPFLSFFHSFLHPFLSFFHSFFILFHSFFHHFFILFYPFFILFYPFFILFILFSFIFHHFFILFFLPFYRDCLKKCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D9P7</accession>
    <name>A0A812D9P7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_49791</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002888">
        <property type="protein sequence ID" value="CAE1293362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D9P7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1293362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="157" mass="17821" checksum="A58C323DDFD0C9C7" modified="2021-09-29" version="1">MPFPSLYYDLAFCLLCFLSFISNLNYFISFFSSPFSSFASLSQQLIGLPYILDSFFYIFLPSNFLPDKLYSPLLSRPLSLFLHAKACLLPFSLSSSARFFSLYLLQQPASYSLLFLLYSIPYALICSPSPSFIIRQSHFSVPGLSSVFVLFPAIFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DAV7</accession>
    <name>A0A812DAV7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_50711</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003009">
        <property type="protein sequence ID" value="CAE1295054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DAV7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="311"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="354"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="383"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="414"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="466"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="490"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="525"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="553"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="580"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="612"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="649"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1295054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="672" mass="82301" checksum="8296D183538E1428" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DCU5</accession>
    <name>A0A812DCU5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_50491</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002977">
        <property type="protein sequence ID" value="CAE1294595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DCU5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1294595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="343" mass="38482" checksum="55F341EF41B22BB0" modified="2021-09-29" version="1">MQLIPGTLQLRNLIKVSLFILPSLCFTHSPTTLSLSLLIFLDHLLSCFAYCSHLFTHSLLFAALTHPPTYFPLLSLLLIFLISFSFSSLKSFPFFVFFLHLSFAHFLFFSLYKSSSSTPTFNPYHLSLYCFLSFYSLSFYYLFCLFSFFLNSHYHFSYFPLFFSIHPFTLFAFFFLFILFLLPFHFHFFLLFFLPFFLSPHLSLRLSVALHLSLRLSVAPHLSLTLSVAPHLSLTLSVAPHLSLTLSVAPHLSVTLSVAPHLSVTLSVAAHLSLCIFPPLSLTLCSSPPLGHTLCSSPPLGHTLCSSPPLSHTLCSSPPLSLSVASYLSLTLSVNPLSLWSCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DDW1</accession>
    <name>A0A812DDW1_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Enhancer of mRNA-decapping protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SPHA_50623</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EDC3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002998">
        <property type="protein sequence ID" value="CAE1294801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DDW1"/>
    <dbReference type="OrthoDB" id="10030313at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031087">
        <property type="term" value="P:deadenylation-independent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033962">
        <property type="term" value="P:P-body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01737">
        <property type="entry name" value="LSm16_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10260">
        <property type="entry name" value="YjeF N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025762">
        <property type="entry name" value="DFDF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019050">
        <property type="entry name" value="FDF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025609">
        <property type="entry name" value="Lsm14-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034107">
        <property type="entry name" value="Lsm16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004443">
        <property type="entry name" value="YjeF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036652">
        <property type="entry name" value="YjeF_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13612">
        <property type="entry name" value="ENHANCER OF MRNA-DECAPPING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13612:SF0">
        <property type="entry name" value="ENHANCER OF MRNA-DECAPPING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09532">
        <property type="entry name" value="FDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12701">
        <property type="entry name" value="LSM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03853">
        <property type="entry name" value="YjeF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01199">
        <property type="entry name" value="FDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01271">
        <property type="entry name" value="LSM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64153">
        <property type="entry name" value="YjeF N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51512">
        <property type="entry name" value="DFDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51385">
        <property type="entry name" value="YJEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="DFDF" evidence="8">
        <location>
            <begin position="292"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="YjeF N-terminal" evidence="7">
        <location>
            <begin position="383"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="233"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAE1294801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="604" mass="67862" checksum="C1A2715E0A266174" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DEU3</accession>
    <name>A0A812DEU3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_51682</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003142">
        <property type="protein sequence ID" value="CAE1296778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DEU3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1296778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="201" mass="23051" checksum="8F5B60AC0FDFDC87" modified="2021-09-29" version="1">MNLLFLFPSSFLLIFSHFSPLPFYLLFLLLPFSLLFSPSTLLIIFVFLPPTFLYSFSPYPPCSLSFLTTLSPFSSISFLQTFSLTVFLLFFLPIFSFFTSSSSPFLISLISPKLLSSLTLPFNYQLSLTIRLVETWVGLSGSLGLSNYLLSIYLSIYLSIYIFIHDATTISIYLSIYLSIYLSIYLSIYLFLSLSLYIYIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DHL2</accession>
    <name>A0A812DHL2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_53860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003443">
        <property type="protein sequence ID" value="CAE1300429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DHL2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1300429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="157" mass="18499" checksum="682F5EA3358305A1" modified="2021-09-29" version="1">MSFYLSIYPSIYLSIDVSPFISIYLSIYLSLSIYLNIYCYEWFIIYLSIYLSIYDSLFISIYLSIYLSIYLSTLVISIYLSIYLSIYLSMTVCSYLSIYLSIYLSIYHLSIYVSVIISKSLRSYLSIYLSIYLSIYLSIYLSISFSSDLSTTFYRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DHT6</accession>
    <name>A0A812DHT6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_52036</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003205">
        <property type="protein sequence ID" value="CAE1297478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DHT6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1297478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="248" mass="28987" checksum="923826752CCCF009" modified="2021-09-29" version="1">MFIPSIFSFILLSCFNYVTLLHFFSSRFSFPGFSFFLFLSLFVNEYIIEFTFPPSLFLLRVLFIVNDVFISCISPQILSLHFSLSLSLSLSLSLSLSLCGSFYSFIMSLNNQFGLHFNAFLTYNTISFFLSFFLSFFSTINTTTHYSFLSFFLSFSLSLLKLIIAFLLSFILLLLLKVISVCFLSSFSTFPTKTHYSFLSFFLSFFLTLPTKTHYSFPSFFLYFFLFSTLTIKDHYSFLSFFFFHSPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DI89</accession>
    <name>A0A812DI89_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_56897</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003795">
        <property type="protein sequence ID" value="CAE1304257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DI89"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1304257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="243" mass="27690" checksum="380065C13B90C10E" modified="2021-09-29" version="1">MILSFNLIHSFDLILYIFLRPFLSIYLSIYLSLSLSLSLSLSLYFSLLIIYLSISVCSLFIYLSITLSVYFSLLIIYLSIYLSIYLSIYLSINFSLFIIYLSISLSIYLFQPVHYLSTHLSLYLSISACSLSIYLSIYFGLLIIYLSIYLSNSLSLSLSLSISVCSLSIYLSIPRTLSLSLFQSAHYLSLYLSISQSIYFSLFIIYLSIYLSISVCSLSIYLSIYLSIYLSIYLSISVCSLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DIC9</accession>
    <name>A0A812DIC9_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_53513</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003413">
        <property type="protein sequence ID" value="CAE1299985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DIC9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032527179" description="Transmembrane protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
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        <source>
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        <source>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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        </submittedName>
    </protein>
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                <person name="Bekaert M."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </reference>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
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        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003780">
        <property type="protein sequence ID" value="CAE1303988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DN17"/>
    <dbReference type="OrthoDB" id="6099974at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF260">
        <property type="entry name" value="MFS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1303988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="215" mass="24031" checksum="A7D05186FC871BCB" modified="2021-09-29" version="1">MGLQFGDAGKSFIAALSLASPFARLLFSNLIRAFIEYYTWRGAMVVLAGINLQMIPLALFLLLSHKGKKKPLNVDSRSKKAADSVTLPESKRTFDVSVLKDPLYITYLFTVSFTLNGAILMYSMLPAFLHKKGLEMKEAAALYSIYGIVAAVPRDINLSIYLSIYLSLCVCMIYNKIAVNISVKKIFIYLSIYLSVHIYLSIYLSIHKSTSSKIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DND6</accession>
    <name>A0A812DND6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_56796</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003794">
        <property type="protein sequence ID" value="CAE1304168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DND6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="366"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="399"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1304168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="428" mass="51500" checksum="FBD10C1437B8947A" modified="2021-09-29" version="1">MTSCLHCLTFTPFFFFLFNHFLRTLLSLFLSLFRYDNSLSFPSTISSFACLPYFTTFLVCFLFLFLFLLFLLFFLLPFLHFYLIPCMLSLFLFFFFYFTSFSVFFFSFLLLHFYLIPCMLSLFSPSFSFYFTSFPVCVLFYFSFLLLHFYLIPCMLSLFSPSFSFYFTSFPVCVLFHFSFLFFLFHLIPSMPSLLFLLPFPSILPHFLILHTFLPFPLPFSSFLPLSSYVISSFLLPFPSFLPQSLYAFSAFCPSIIHLFISFLVRIFLLSLSISFFFYLIPCICSVVFLLPYFTSFLVCFLFFSFSSFFFNLFLVYILFFPFLYFFLLSSYFFLFLLPFPLFPLFPRMYSLFSPPFSFYFTSFPVFLLPFLLFNLFFYVFFSLSFSSFLFVIRFLFRLLLLIFFFFSFIIIHFLSPHLIFLFFFITF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DR38</accession>
    <name>A0A812DR38_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_58715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004034">
        <property type="protein sequence ID" value="CAE1306492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DR38"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1306492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="197" mass="23723" checksum="71FFED842360F717" modified="2021-09-29" version="1">MLALLSGSALLLGYIMFDVHYFIRTIVVVSYCSLRTKLLGKRDLMEEDNYLGNSFFYLFSSFSFFYLFFFFLLSLLFLSFIFSLLLSFLFFYLFSSFIFSLLFSFIFSLLLSFLFFYLFSSFSFFYLFFFFLLSLLFLSFISSFSFFYLFFFFLLSLLFLSFIFSLLFLSFIFSLLFLSFIFSLLFLSFIFSLSFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DR55</accession>
    <name>A0A812DR55_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cadherin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SPHA_61119</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004296">
        <property type="protein sequence ID" value="CAE1309426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6252479at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050174">
        <property type="entry name" value="Protocadherin/Cadherin-CA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028:SF328">
        <property type="entry name" value="CADHERIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028">
        <property type="entry name" value="CADHERIN-87A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032732602" description="Cadherin domain-containing protein" evidence="8">
        <location>
            <begin position="33"/>
            <end position="1456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="363"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1422"/>
            <end position="1448"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="9">
        <location>
            <begin position="120"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="9">
        <location>
            <begin position="246"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="439"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="561"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="636"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="715"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="955"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1178"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1238"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1328"/>
            <end position="1380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="440"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="567"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="652"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="727"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="753"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="786"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="803"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="828"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="859"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="956"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1188"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1248"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1330"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1357"/>
            <end position="1373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAE1309426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1456" mass="164071" checksum="D7F9F429AC990E2E" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DSV6</accession>
    <name>A0A812DSV6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_59311</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004104">
        <property type="protein sequence ID" value="CAE1307161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DSV6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1307161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="362" mass="42419" checksum="47BF45D9BAADCA2F" modified="2021-09-29" version="1">MSNETSSMEQSYTPASSSDLSIYLSIYQSIYHSIHIYLSIYLSIYLSIYHSIHIYLSIYLSIYLSITLFISIYLSIYLSLYSYLSIYLSIYLSFTLFISIYLSITLFISIYLSIYLSFTLFISIYLSIYLSFTLFISIYLSIYLSITLFISIYLSIYLSIYLSFTLFISIYLSIYHSIHIYLSIYLSIYLSLYSYLSIYLSIYLSIFHYIHIYSYLSIYLSIYLSIAIYTSFVSLCIYLSHSVHIYLSIYLSILDSSCFYLCIYLSNPSVSIYLSIYLSIYLSIYLSISACSYLYQSIYLSDEILLRYDLIHGRKYCLDLISLKVQSPFIKDEQTEVMNPLSDGRFAIGCTGMWTATHVRQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DXQ0</accession>
    <name>A0A812DXQ0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_62766</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004489">
        <property type="protein sequence ID" value="CAE1311236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DXQ0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="316"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="353"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="380"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="417"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="447"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="475"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="502"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="542"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1311236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="565" mass="64207" checksum="C1B5CF040F618565" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DYA1</accession>
    <name>A0A812DYA1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_63793</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004577">
        <property type="protein sequence ID" value="CAE1312548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DYA1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1312548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="197" mass="23364" checksum="89496337F92B0DA3" modified="2021-09-29" version="1">MRTRKLVSGRKAEACSYLSIYLSIYLCQSRHYLSIYLSIYLSIYLSMVPTTNYLSIYLSIYLSIYLSQSLHNLSIIEVYFFFILSIYLSIYLSIYLSIYLSLFIIYLLSKFIFSFFYLSIYLSIYLSIYLSIYLVSGHICLSINMHTYPGITKNWLLKMFIFFYIACLCIYLCIYQQSISLSIYLSIYLSIYLSNLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DZE1</accession>
    <name>A0A812DZE1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_61944</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004391">
        <property type="protein sequence ID" value="CAE1310295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DZE1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="319"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="348"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1310295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="399" mass="48239" checksum="64730D8A0FD85676" modified="2021-09-29" version="1">MGVAPAELELARRITISIQLFPFPEVCIHFWSDYLSIYLSIYLSIYLSIYLSIYLILLLFYLSIYLSIYLSIYLILFIIYLSIYLSIYLILFIIYLSIYLSIYLSIYLSILSISFCSLSIYLILFIIYLHSFLIYLSIYLSHLSIYLSIYLSHSVHYHYLSIYLSIYLSIYLSVSSFFLSFFLSLSVSFFLSFFLSFFLVCECFYSSNNFLFFFLLSFHLITFLSSFRSFFLSFFIYIALSFFLPFCHFSFLLVDFSIRVTIFFSFFFFSYLSFFHFLFLFPSYFILYFDLSFFLVYFCIRVTIFFFLLFQYFYSRNNFIFFLFSYLLLFYILFFCSFFLFGRFFMSFFPLSFFFSFILSSSYRSFFFSRCFMLLSCSTLSHSLLLSHCFLFPSDLFSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E2M8</accession>
    <name>A0A812E2M8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_64906</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004678">
        <property type="protein sequence ID" value="CAE1313876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E2M8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="673"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="707"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="736"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="763"/>
            <end position="784"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1313876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="791" mass="86526" checksum="CC5BB2D245B5EAE4" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E379</accession>
    <name>A0A812E379_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SPHA_67449</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Synapse</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004892">
        <property type="protein sequence ID" value="CAE1316807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E379"/>
    <dbReference type="OrthoDB" id="10059918at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048788">
        <property type="term" value="C:cytoskeleton of presynaptic active zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042734">
        <property type="term" value="C:presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044325">
        <property type="term" value="F:transmembrane transporter binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048791">
        <property type="term" value="P:calcium ion-regulated exocytosis of neurotransmitter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050806">
        <property type="term" value="P:positive regulation of synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048167">
        <property type="term" value="P:regulation of synaptic plasticity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039032">
        <property type="entry name" value="Rim-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12157:SF24">
        <property type="entry name" value="FIFE, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12157">
        <property type="entry name" value="REGULATING SYNAPTIC MEMBRANE EXOCYTOSIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0770">Synapse</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="428"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="468"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="325"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="347"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="364"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="391"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00034103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAE1316807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="490" mass="55429" checksum="2CEC9B8E478E1362" modified="2021-09-29" version="1">MRVVGGKLGEDNRLGAYVRSVESGGPADLQGNIREGDQILTWDGQSLVDVTYEEAQEIMDRSGNIVQIVIWHRPITEEDTVGPTAAERREKFQKADSADVELTETKDKEFENLGIKRKRRILPKTPLEIKKDTTRVIVGRLQMKINYISEKMKLTITIMKVVDLVPPDKPKRKIPSPLAMLRLLPSSFLLFPFYFLLSFFLLSFFFVLFLSTPFTFILFFTHFLSLSMYISFHFPLLTRINIFYPLSLSTTYIYKCSLFILFFLSLLSFYLSFFLSVFIPHRSLKTTALEVTLWSFNKNADDTFIGEVLLDLYEAALDDQPTWYDLEDHDENSSPLPDRTKMYPENSPMSSTSTETSRTGTPCRGSSPSPFNRSPAGSFSQRSMSVTPTHDKRKHLLSKKSPGKHSFSPSVSFSPPPLSLSLSFSPTLSLFLSLSFSLSLSLSLSLFLSLSPHSLSLSFSLSPPSLSLSLPLSFSLSLYVPLFLSILVYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E5P3</accession>
    <name>A0A812E5P3_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CARD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_68541</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004991">
        <property type="protein sequence ID" value="CAE1318047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E5P3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01671">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001315">
        <property type="entry name" value="CARD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00619">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50209">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CARD" evidence="1">
        <location>
            <begin position="26"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1318047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="184" mass="20794" checksum="492DD6E515DF8F1E" modified="2021-09-29" version="1">MADEMETDACLVNESGQRTGYDKFRLKRIQACLVESMDTVEVRKLIDLLRAKGIFNSFEYETVFYEQITENAIRKLLDILKDKVDNIDGSLAFDVFVNFLKDDCGNEEIAQALIEADGYPECYKEALEAIEVAEGMNMSDKILGGVIRHISGNWKAVAHQLDMLPFIPKEVLVLLSIQTSIFSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E642</accession>
    <name>A0A812E642_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_68801</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005024">
        <property type="protein sequence ID" value="CAE1318308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E642"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1318308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="272" mass="31279" checksum="80008F433A31FF04" modified="2021-09-29" version="1">MLLCLCRKLSGRPTIQFLCHRDTHIDFSPDLSKLTNSQMTPPLPPSAPTFPVPRRFLPSFIISASTLNQVSLLARTSFRFFFLFLPLNFNTQTYTQLKLTSTHYSLPSLSVCLSFFLSFCLSFFLSFFLSFFLSFFLSFFLSCLLSFLLSVCLSVCPYFFLSFFLSVSFSFFLSVCLFVFLSFCLSVSLSSFLSACLSFYLSVRLSFFLYFCLSVRLSFFFFCLSVILSFCLSVCLSFFLSFFLFVFLSARLSFIHFFLSVSLSVCLPVFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E7G0</accession>
    <name>A0A812E7G0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_67049</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004841">
        <property type="protein sequence ID" value="CAE1316302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E7G0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="318"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1316302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="340" mass="41576" checksum="EEA4812EBB08F13D" modified="2021-09-29" version="1">MSSFLSFFLSFFLSFFLCIYIEQFSLQIFFSVFFCFLFFFFSFLLHSLLLLSTFSLYSFFFFFFRFISFFSHCCFILSFTFSLLSFIVFLILYFILFFALFILLFRHFLFFVFLFLIPLSSPRFIILSFHFRFFYLFVLLSFNSFFFFFSLFSSRHFFFLLVQSLFHLSPSFSFACSLRFVYFFLFLSFPFIFCLFFPFPNLSCFSLFLFLYLFTIISAPLELYLLFFLSLFPSLILSFFLLSFCSILHFILSLFSNQYIPLFIFFFLSLYFLSFFLFSLCPFCTSLSFFLSLFIHAFIYLFIFLFHSFYFLKIFLQYFFLFSFSSSFHYLSFVLSFFIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E878</accession>
    <name>A0A812E878_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_68275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004961">
        <property type="protein sequence ID" value="CAE1317758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E878"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="308"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="339"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1317758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="369" mass="43519" checksum="4F121E0AF9A57E94" modified="2021-09-29" version="1">MSSGMLMFLLAVTSLLLSVFLSPVKMMMILPYAVYHSIVIITVLGSSLIELWEPRSVFAACLLGPERPFSLSHRACIFHVFVIRRIYLIYSLPKEQSILSLFIHSLIMLSYFLSFSFFLSFFLCLILYYVLLFLSVNSLSFFPFFLSLLCAFRQLPSFLSLFAQCFDTFFYFLVLSFLLSFFVQCFHSFFYFLVLTIFLSVFLSIFHGLALSLFLLYAFIRSFISLCVQNFIRCSELSYFQFLLLSFFICLVLSNFLLFFSAFFLSYCFHIFSYFFGSFFLSLCFQTFFYFLVLSFLLSFLTLSYFHLFLNAFFLSLLSHFLLFLSAFLLFLFLFLNSFFLSFCFYLGVSYLFLFLRASFLSFFICVMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EA53</accession>
    <name>A0A812EA53_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_69654</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005098">
        <property type="protein sequence ID" value="CAE1319241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EA53"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1319241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="155" mass="18404" checksum="C99760061A64E76A" modified="2021-09-29" version="1">MQYIQIYLSIYLSICLSIYLSIYLSVYLSIYLSIYLSIYLSIYLYFFIDTSDFMQFPLSLDLFVAVYSYISIYLSIYLSIYLSISVSSYLSIYLSIYLSIYLSIIILFSSYYIYWSVSIYLSIYLSLFLSFFLSFFLSIYLSIYLFNCLSILEPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EDB5</accession>
    <name>A0A812EDB5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FUBP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SPHA_68780</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005024">
        <property type="protein sequence ID" value="CAE1318330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EDB5"/>
    <dbReference type="OrthoDB" id="5204190at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22396">
        <property type="entry name" value="KH-I_FUBP_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22397">
        <property type="entry name" value="KH-I_FUBP_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22398">
        <property type="entry name" value="KH-I_FUBP_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015096">
        <property type="entry name" value="FUBP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09005">
        <property type="entry name" value="FUBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="6">
        <location>
            <begin position="101"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="6">
        <location>
            <begin position="188"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="6">
        <location>
            <begin position="288"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="6">
        <location>
            <begin position="408"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="20"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="269"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="373"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="440"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="543"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="583"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="686"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="271"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="373"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="480"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="495"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="520"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="583"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="686"/>
            <end position="697"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAE1318330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="706" mass="73950" checksum="E4720F34CFB85AD2" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EF94</accession>
    <name>A0A812EF94_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_71222</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005210">
        <property type="protein sequence ID" value="CAE1321071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EF94"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="311"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="398"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1321071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="429" mass="53011" checksum="233236B5E3A5683B" modified="2021-09-29" version="1">MLFSSFISLFILTFFFLPFFLPFFLPFFLPFISFFLYLFFFSSFLFFNFSLSFLFPFFLPFFLPFFLSSFFFPYFFSYAITHFFNFSFFLSFFLSFFLSFFLSFFFFFPYFSLTLSLIFNFSFFLSFFLSFFLSFFLSFFFFFPYFSLTLSLIFNFSFFLSFFLSFFLFSSFPFFLLFFLRYHSFLTFLFLPFFLSFFLSFLLSLFFSLTLSLIFFLFFLPFFLSFFLSFSSFPIFLLRYHSFLTFLSSFLSFFLSFSSFPIFLLRYHSFLTFLSFFSFFLPFFLSSFLSSFLSSFLSFSSFPIFLLRYHSFVTFLSSFLSFFLPFFLFLLSLFFSYAITHFFFSFFLSFFLSFFFFFPYFSLTLSLIFNFSFLLFFLSFFLSFFFFFPYFLLPFLSFFLSFFFPFFLFSFLSFFFFFLSFFFAITHFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EFZ8</accession>
    <name>A0A812EFZ8_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Diacylglycerol kinase</fullName>
            <shortName evidence="11">DAG kinase</shortName>
            <ecNumber evidence="11">2.7.1.107</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SPHA_72404</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Farmed</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10272"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.107"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the eukaryotic diacylglycerol kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.107" evidence="11"/>
    <dbReference type="EMBL" id="CAHIKZ030005320">
        <property type="protein sequence ID" value="CAE1322441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EFZ8"/>
    <dbReference type="OrthoDB" id="242257at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004143">
        <property type="term" value="F:ATP-dependent diacylglycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007200">
        <property type="term" value="P:phospholipase C-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20851">
        <property type="entry name" value="C1_DGK_typeI_like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20799">
        <property type="entry name" value="C1_DGK_typeI_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000017">
        <property type="entry name" value="Diacylglycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10330:FF:000003">
        <property type="entry name" value="Diacylglycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.110">
        <property type="entry name" value="Diacylglycerol kinase alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029477">
        <property type="entry name" value="DAG_kinase_typeI_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037607">
        <property type="entry name" value="DGK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038199">
        <property type="entry name" value="DGK_typeI_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000756">
        <property type="entry name" value="Diacylglycerol_kin_accessory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11255">
        <property type="entry name" value="DIACYLGLYCEROL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11255:SF48">
        <property type="entry name" value="DIACYLGLYCEROL KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14513">
        <property type="entry name" value="DAG_kinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00609">
        <property type="entry name" value="DAGK_acc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00045">
        <property type="entry name" value="DAGKa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 11 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="EF-hand" evidence="14">
        <location>
            <begin position="109"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="14">
        <location>
            <begin position="154"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="12">
        <location>
            <begin position="204"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="12">
        <location>
            <begin position="269"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="DAGKc" evidence="13">
        <location>
            <begin position="367"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAE1322441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="726" mass="81732" checksum="8E0199E18855D740" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EHV8</accession>
    <name>A0A812EHV8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_73499</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005380">
        <property type="protein sequence ID" value="CAE1323562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EHV8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1323562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="170" mass="20700" checksum="ABE3CF6C7E06E384" modified="2021-09-29" version="1">MPFCFISLFLYMSFIHNYFSFLHSYLFLSLIIIHIFCLHFIFIFRPSLFFFLSFRFPFSFCLIPHCFIFVRSFIFVSFLYSFSLTYPFSFAYFNQFMSHLYIICEFSFFCIRCCFFLHFFYFVPLSFAFPSFLSFLFFFPLYFVSFLLCGSHHFSFISFSSLPASLICLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EJ59</accession>
    <name>A0A812EJ59_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_72212</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005303">
        <property type="protein sequence ID" value="CAE1322198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EJ59"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1322198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="208" mass="23557" checksum="6085A7C11556B01B" modified="2021-09-29" version="1">MVDFNAKLLSPSFLSFFLSFFLSFFLSVFLSFFLPVFLSFFLSIILPILCLLDSSNSLLLDFLLDSSNSLFAILPILFLILPILCLLDSSNSLFARFFQFSILPILFLLDSSNSLFARFFQFSVCFLPILCLLDSSNSLLLDSSNSFFARFFQFSILPILCLLDSSNSLFARFFHSLLLILPILFLLDSSNSLLLILPILCLLDSFSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ENW5</accession>
    <name>A0A812ENW5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_76107</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005480">
        <property type="protein sequence ID" value="CAE1326541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ENW5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="287"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="325"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="388"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="417"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1326541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="457" mass="53043" checksum="5D7A27948F681024" modified="2021-09-29" version="1">MGHTDFDGMAFYHNRISSLQNTQSLSEASLSQIPIPPQNPHMCHQRLPTTTLSTWSHQSFLLSVSDKLFYFLLEFSPLFSSVFPLFLFLFLSNIFSSLFHSKFICSSCFFPLFLFSSILPFQSIFSITFFFSYSLSHLFYNFYLFSFSLSFYPLSLSPFLLFFVFLLFSYSLSLSLFLLFFVSLLFFILCLSLFFVSSFSLILCLSFFLFCLSPFLLFFVSLSFLLFFVSLSFSLILCLSLFFSYSLSLSFSLILCLSPFLLFFVSLSFSLILCLSLLFSYSLSLSLFLLFFVSLSFSLILCLLFLSLSLFFSYSLSLSFFSYSLSLSFLFILCLSLFSLILCLSLSFLCLLFFFVSLSFSLILCLSLFFSYSLSLSFYFCHILYSRPLVWGGEFLFPYFFSMIFIIYLTYFSFNLFLPFFCFLSSSLFHCLPHLSLSLSLSLSLSKFPLFFFHHTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EP24</accession>
    <name>A0A812EP24_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_74744</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005438">
        <property type="protein sequence ID" value="CAE1325087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EP24"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="324"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1325087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="350" mass="40931" checksum="6EEC252B177A8512" modified="2021-09-29" version="1">MVLIFQHSPSLPLSLFLSLSLSDIYTRIRTHVYIYFLLSVCFSIYLSISVRYYIYILYVPIHVLILYILFWLSIYLSIYLSIYLSISMYSLSIYISIYLNLFIIYLSIYLSIYLSIYLNVFIIYLSIYLSIYLLWSSYLYHCDSPSPITLSILSIYLSECIHYLSIYLSIYLSQSFSISLSYICLYMYSFLLYFLCAVCLSVILSIYLSIYLSIYLSIYLSIYLSIYLSQFVFYLYSLCLCVSVSLCLPLSLSLSHSLSLYLNHLICLSRSANIYLSIYINHLISLSLSQSANIYLSIYLSIYLNQCLKSPNDAHHDATIYLSIYLSIYLSISLSLSLSIYIYIYIYKQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EPN1</accession>
    <name>A0A812EPN1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_79959</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005584">
        <property type="protein sequence ID" value="CAE1330671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EPN1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1330671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="265" mass="31847" checksum="0A7406DF37487938" modified="2021-09-29" version="1">MLLFLGRITSKIAIVHIYLSIYLSIYLSIYLSMSLHNYLSIHLSIYLSMSVHIYLSIYLSIYLSMSVSFFLSFFLSFFLLEFLSFYLIAFFFLSFFLSFFVLFLSISFFYLSIYLSIYLSIYLSIYLSQSLFLSSILSFFLPIRISFFLLEFLSFYLNFFLSITVCFYLSIYLSIYLSIYLSISVSFFGSSFLPSFLPFFFFPPLLISSYLFKPPFFSFFLSFFLYLFIYLFILLFLSFFLSTYFYCFSFLYLLSLQLYFYFFID</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ESB7</accession>
    <name>A0A812ESB7_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">OCIA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_78645</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005546">
        <property type="protein sequence ID" value="CAE1329075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ESB7"/>
    <dbReference type="OrthoDB" id="6513616at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040187">
        <property type="entry name" value="OCAD1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009764">
        <property type="entry name" value="OCIA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13336:SF3">
        <property type="entry name" value="OCIA DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13336">
        <property type="entry name" value="OVARIAN CARCINOMA IMMUNOREACTIVE ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07051">
        <property type="entry name" value="OCIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OCIA" evidence="2">
        <location>
            <begin position="44"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="200"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07051"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAE1329075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="488" mass="56447" checksum="0786B9184A0BD1FA" modified="2021-09-29" version="1">MSSNGGPGSRTEDDLPRIGQWKNFQNPHPELPNPHLSQKTPVSLTKEELRVLQECNRESFWYRSIPACLFCVGITQFAVNKGYLKPHPKYGAGLKTLGAALLGYILGKISYQNECRKKIMALPNSQLAETLRQRLSRERGPSEFTMKSVSSDMLENPQVPQTEHTASDAFDTETNQVAPSTVKFEDLSSGNSGEQESQYRSYGDLRRQNREIYSENQVVKWQNIQNKNRNPQPNISQTPEEKSSQWTPSYSTTQPRAPTNKYGDVWEDQIVATFFPIRKVATFFPIRKVATFFPIRKVATFFPIRKVATFFPIRKVATFFPIRKVATFFPIRKVATFFPIETCDFLSYPKICDFLSYRKVATFFPIRKVATFFPIRKVATFFPIRKVATFFPIRKSCDFLSYPKSCDFLSYLKSCDFLSYPKSCDFLSYRKVATFFPIRKVATFFPIRKVATFFPIRKVATFFPIRKVATFFPIRKVVTFFPYEIEFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ESY9</accession>
    <name>A0A812ESY9_ACAPH</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="CAE1329164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ESY9"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    </feature>
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        </location>
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        </source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ET87</accession>
    <name>A0A812ET87_ACAPH</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
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        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
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            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
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    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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            <begin position="191"/>
            <end position="211"/>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="213" mass="24665" checksum="183A3AE5C098CB0E" modified="2021-09-29" version="1">MLCDALFSIRPLLYTVTSCTGQERMTSYPRKSTSRRSVPSWLTVSGKVLVRNYVQNNKHEANGREVELIEANPDYAFLRKASFLVELITPKAAYVITSPLIRDEFVANELRRHPLRPVFSTPCIPLSGLRTREACAGRSLGRYETVRTVQYVDLSFFPESIASFIYPFLFPVFFFRLIFLSFFFLCDLLIFWGKFILLLSIYLSIYLSIYLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EV00</accession>
    <name>A0A812EV00_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <authorList>
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                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000597762">
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    </dbReference>
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        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AJM5</accession>
    <name>A0A812AJM5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_277</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000003">
        <property type="protein sequence ID" value="CAE1138708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AJM5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="279"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="317"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="399"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="434"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="460"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="498"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="526"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="553"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="582"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="607"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1138708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="633" mass="74489" checksum="C5FA57492E6BEAA3" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ALE0</accession>
    <name>A0A812ALE0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="13">HVCN1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SPHA_458</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000007">
        <property type="protein sequence ID" value="CAE1139800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ALE0"/>
    <dbReference type="OrthoDB" id="427456at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030171">
        <property type="term" value="F:voltage-gated proton channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031846">
        <property type="entry name" value="Hvcn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46480">
        <property type="entry name" value="F20B24.22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46480:SF1">
        <property type="entry name" value="VOLTAGE-GATED HYDROGEN CHANNEL 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="513"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="540"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="138"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="230"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="577"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="68"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="299"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="324"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="351"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAE1139800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="596" mass="64892" checksum="9219805B5CC1A7CB" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AML1</accession>
    <name>A0A812AML1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribose-phosphate pyrophosphokinase 4,Ribose-phosphate pyrophosphokinase 3, mitochondrial,Ribose-phosphate pyrophosphokinase 3, chloroplastic</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SPHA_1302</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Farmed</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000036">
        <property type="protein sequence ID" value="CAE1143482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AML1"/>
    <dbReference type="OrthoDB" id="10263753at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002189">
        <property type="term" value="C:ribose phosphate diphosphokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210:SF45">
        <property type="entry name" value="RIBOSE-PHOSPHATE PYROPHOSPHOKINASE 3, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01400">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="3">
        <location>
            <begin position="238"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAE1143482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="339" mass="38288" checksum="30C9CDC434B49ED8" modified="2021-09-29" version="1">MESLAMEIADRCTLSQNLLSSSTAKTEGNEASDVDPTHSQALEKFGRRKRQVEFHKTINWGSFDDGFPNIFISDVNYMKGKDVIFLGSFHSPEIIFEQLSVLYMFPRYRARSFHLLLPYFPTGTMERVENEGEIPTAKTLASLLSHIPLTTKGPAQITILDIHALQERFYFSDNVIPRLESAIPLLKLELEHVFGQGNYTVAFPDDGACKRFKSYFPQDDCIIFNKTRVGNKRNVQIKDGDPNGKTVVIVDDLVLTGGTLKETGRILKENGASSISAYVTHAVFPKESWKKFVDSDVFDNFWITDSIPHSRILCQYKPFKLLSLCDVIANCLLGYDLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AVN7</accession>
    <name>A0A812AVN7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_4631</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000148">
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="5" xmlns="https://uniprot.org/uniprot">
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        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
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    <name>A0A812B437_ACAPH</name>
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        <recommendedName>
            <fullName evidence="6">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAE1168841.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B4H2</accession>
    <name>A0A812B4H2_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heme-copper oxidase subunit III family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
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    <organism evidence="3 4">
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        <name type="common">Pharaoh cuttlefish</name>
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        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000309">
        <property type="protein sequence ID" value="CAE1167865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B4H2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000298">
        <property type="entry name" value="Cyt_c_oxidase-like_su3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23304:SF189">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23304">
        <property type="entry name" value="SPOT2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50253">
        <property type="entry name" value="COX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="307"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="392"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="419"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="451"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="485"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="514"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="542"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="570"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="603"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="645"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="domain" description="Heme-copper oxidase subunit III family profile" evidence="2">
        <location>
            <begin position="140"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1167865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="669" mass="80650" checksum="A63BCA996A8ABB5E" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B4Y7</accession>
    <name>A0A812B4Y7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_10140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000326">
        <property type="protein sequence ID" value="CAE1168635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B4Y7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="51"/>
            <end position="69"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="81"/>
            <end position="100"/>
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            <begin position="178"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="201"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1168635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="275" mass="32709" checksum="7CC13871C51C13D4" modified="2021-09-29" version="1">MTLYSFIPETVNTCIYLSAYYLISIYLSIYLSIYLSIYLSIYLSHSIHSSIYLSHSIHSSIYLSIYLFIHPSIYRILLTHLSIYLSIYLSIYLSIYRILFIHSSIYLSIYLSHSINSSIYLSIYLSIYISIYRILLTHLSIYLSIYLSHSIHSFIYLSIYLSIYLSIYLSISIHLTHLSIYLSIYLFIYLSHLFIHSSIYLLSIYLSISVIYLSIYLSISFWPLLIQFSLLKYIFLKTETTNQFSFSFVFHLFCLFKNFLSNLFPFFFEILKHFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B5S7</accession>
    <name>A0A812B5S7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_10410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="CAE1169026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B5S7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAE1169026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="278" mass="31459" checksum="8679A89FCD54E85A" modified="2021-09-29" version="1">MAAMLQCTRLCRRHLFTRVVRRSRQLPVVWHDGCGRYFRCHFKTQAKWMPQNIFLQMQLVRCATQATVVETLPPTLYFPHKFLYRHPLSHLSFFFSPFSQPSLLSFPPSPSLLSSLLPSPLSLLFTFLAPLSLPPSPLSLSLLALLSLLSHLSLSLSLSLSLSLCYHLSFLSSLLSLFSDLSFKSLPLFTLSFIFSHFGYFLFSFSFSPSLSFSLSLSLSLALSLSLSLPSASFSLSFQVMDIFVRLHLSIFGETVTRMTLSILHRLSHTLRALKKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B650</accession>
    <name>A0A812B650_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_11737</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
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            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
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            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
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                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000390">
        <property type="protein sequence ID" value="CAE1171754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B650"/>
    <dbReference type="OrthoDB" id="6162929at2759"/>
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    </dbReference>
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        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
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        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1171754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="448" mass="52489" checksum="D67F85328F41B1CE" modified="2021-09-29" version="1">MTSYHTVKGHRVCCVCNGNAFCFLPSTSLHIIFLSPTFPPIPLSFSLSHFSFLSFSFFFSFSPCLSIYLFLSFFRTFFLSFFLSFFLSFFPTVYISVFTYLSIYLSIYLSISVYIFNSQRPIQVLFLKFTHIPSILEFIHIPSNLKFIHIPSILKFIHIPSILEFIHIPSILKFIHIPSILESIHFPSILEFIHIPSILEFIHIPSILKFIHIPSILEFIHIPSILEFIHIPSILEFIHIPSILKFIHIPSILEFIHIPSILEFIHIPSILKFIHIPSILEFIHIPSILKFIHIPSILEFIHIPSILEFIHIPSILEFIHIPLFSNSFTFPHFEFIHIPSILKFIHIPSILKFISFLYSRIHSHSLYSRIHSHSLYSQIHSHSLYSRIHSHSLYSRIHSHSLYSQIHSHSLYSRIHSHSLYSLFQLFLSNGNYHMLPCDILLYLCCSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B676</accession>
    <name>A0A812B676_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_10853</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000355">
        <property type="protein sequence ID" value="CAE1169946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B676"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="373"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="401"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="428"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="454"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="490"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="520"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1169946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="552" mass="64019" checksum="A56B889674BF6D6E" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B6B7</accession>
    <name>A0A812B6B7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_11746</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000390">
        <property type="protein sequence ID" value="CAE1171743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B6B7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1171743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="253" mass="29673" checksum="CF825DF2E6A143B3" modified="2021-09-29" version="1">MESFVYFLNKQYIYLFDSVHIYLSIYLSILVFSLSIYLSIYLSIYLSFSSCSCSSLSLSLFIYLSIYFGVFTIYLSIYLSIFFFNFFFFSLSLSIYLFDSVHIYLSIYLSIYLSIYLGIYLSVFFFLFLLFSLSLSLSIYLSISVFSLYIYLSIYLFLLLLLLLSLFLSIYLSIYLSIYLILFISIYLSIYLSISVFSLSTYQSFSSCSCSSLSLYLSIYLSIYFDVFTIYLSLSVFSSNELNLNLLNFSFLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BA85</accession>
    <name>A0A812BA85_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_13688</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000459">
        <property type="protein sequence ID" value="CAE1175545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BA85"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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            <end position="46"/>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="150"/>
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        </location>
    </feature>
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        <location>
            <begin position="180"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1175545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="271" mass="29231" checksum="F4C7A512CD2B9A07" modified="2021-09-29" version="1">MAHFSLSFSLSVKLVLPLSQFISVCLSHFISASLSLSQFISACLSLSFAHSQLNSSCLSLSSYLSAFLSLSFAHSQLNSSSLSVHICLLFSLHICLSLSLTLCSLSVRILPASLSPICLPFSFHICLSLSPSLSSFLLASLSFCSLSVKFFLPLSQFISVCLSLFLSFAHSQLNSSCLSLSSYLSAFLTSYLPLSLSLSFAHSQLNSSCLSLSSYLSAFLISYLPLSLPLSVHFCLPLSLSFFHSQLNFSCLSLSSYLPLSLSLSLLLTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BAE0</accession>
    <name>A0A812BAE0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RBBP8</fullName>
            <ecNumber evidence="7">3.1.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SPHA_13662</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="7"/>
    <dbReference type="EMBL" id="CAHIKZ030000458">
        <property type="protein sequence ID" value="CAE1175492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BAE0"/>
    <dbReference type="OrthoDB" id="5801062at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010792">
        <property type="term" value="P:DNA double-strand break processing involved in repair via single-strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013882">
        <property type="entry name" value="Ctp1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033316">
        <property type="entry name" value="RBBP8-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15107:SF0">
        <property type="entry name" value="DNA ENDONUCLEASE ACTIVATOR CTP1 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15107">
        <property type="entry name" value="RETINOBLASTOMA BINDING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08573">
        <property type="entry name" value="SAE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA endonuclease activator Ctp1 C-terminal" evidence="6">
        <location>
            <begin position="495"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="164"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="380"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="553"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="92"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="164"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="566"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAE1175492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="598" mass="68771" checksum="8BD78E9CD96636BF" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BAE4</accession>
    <name>A0A812BAE4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_12634</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000422">
        <property type="protein sequence ID" value="CAE1173447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BAE4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032978328" evidence="2">
        <location>
            <begin position="24"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1173447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="354" mass="40810" checksum="23FF0C38064BB399" modified="2021-09-29" version="1">MSSFNSSILLLLLFLCWSLCVLSRAWSSFYSSFNSSILLLLFFFVGLLCSVLQFIHIIIIISCWSGLGPRCNSISFSRNMSSSIHPYYYYYLLVFSAGNMSSFSIHPYYYYYFFVGLLCSGNVFFQFIHIIIIISFCWSLVFYPRLQGLGSTTRALVVFFSIHCNYMLLLCSVPGNLYVFFQFIHIIIYYFFCWSLVEHVFFLFIHIIIIISLLVSLCSVLQVWVHACNSMLVSPAGLGPNSMLLGLGPRCNSMFLGKYVFQFIHIIIIISLFVSLVSVLRAWSTEHVFFQFIHVIIIIYFFVGLLCSYPAGLGPYCNSMFLLGNVFFQFIHIIIIISFCWSLYVLSCRAWSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BBK7</accession>
    <name>A0A812BBK7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_13215</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000441">
        <property type="protein sequence ID" value="CAE1174624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1174624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="3176" mass="368372" checksum="4C5B2A722D13E63D" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BCJ2</accession>
    <name>A0A812BCJ2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_14157</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000480">
        <property type="protein sequence ID" value="CAE1176411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BCJ2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1176411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="182" mass="20609" checksum="C5CEB6EE54168151" modified="2021-09-29" version="1">MTERLSPRRGSLFFPNVGGSLAIFFPTSLKFLSPSRGQSGQEDFPPRRGSLAKKTFPKITKDFPHVRSLKKFPQSLAKHHVGAVWPKFFPHFVIWPRRLSPRRGQSGQEDFPHRGQSGHIFPRHSLAIRLSPRRGSLAKKTFPHVRGSLARRLSPRQGQSGLLDFPPSGAVWPFPHVRAVWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BEJ8</accession>
    <name>A0A812BEJ8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_15998</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000558">
        <property type="protein sequence ID" value="CAE1226295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BEJ8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="208"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="272"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1226295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="312" mass="36224" checksum="201151C4E4F3009C" modified="2021-09-29" version="1">MGTRKAKVILHRVSLFISESHLGFFFSKYGDVSDVCPIKVKKHEENTTRRLPSSPLNAPLSNIRNSTHQTPPSNTTAADDISTPLHILLSTSTPAYRLISLSLSLSLYLSIYLSIYLFVSYYIDFHFYLSIYLSIYLSHSFYLSIYPYRLISLFHFIIYLSIYLSIYLSHSFCFIYLSIYLSIYISFVSFLSIYLIRFICYLSQSFNLYLSIYLSIYLSIYLSIYLSIYLIISFHYLSIYLSIYLSIYLSIYFIRFICCLSQLSNVSLSIELSIDIICFIIYLSIYLSIYLSIYLSQSTCFFPNVDVCSGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BEY7</accession>
    <name>A0A812BEY7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_15392</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000535">
        <property type="protein sequence ID" value="CAE1178826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BEY7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1178826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="333" mass="40654" checksum="D4A067154206B422" modified="2021-09-29" version="1">MRNLQVTLNAFILHYLFLSFLRSFFLFLSFFLSFFSLFMRYLLETFIFLFLFFLSFFLSFFLSFFLSFFLSLTEIKYLLETLKTYIPAFLPSFFLPSFFLSFFLSFFLSFFLSFFLFFFSLKPNNVFPPLSTIIYKAFAGSGILYPLQRICFPRIGYPKTNVAKIRIYKRNKKKQVKWQGYLWHLRFIFCLKRLFFLSFFLFAVFFLSFFLFTVFFLSFFLFICCFLSFYLSFFLFICCFLSFFLSIFLSCLSISRFSSIYFQSETTFYLSFLSFFLSTNILASFFLFLFVFYKLLSFFFSFFLKRFKVLLLDFLMFLSKSIYYLSIYLFYIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BGX4</accession>
    <name>A0A812BGX4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_18371</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000664">
        <property type="protein sequence ID" value="CAE1232082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BGX4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1232082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="169" mass="19897" checksum="B884CA62C5FFAAD8" modified="2021-09-29" version="1">MLSGHSFFLSFHSHSFFLSFFLVILSLLFLFSVSLTISLIHSLTNSLTFSFFLSFFLSFFLSFFLYPTFLSFFLSFFLSFFLSFFLFFTQPFFLSFFLSFFLSFFLSFFLSFLSLALSLSIYLSLSLSLSLYIYIYIYIFSFYIITSSLSLSLSFTFVYFLFPLPVPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BH22</accession>
    <name>A0A812BH22_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_17383</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000620">
        <property type="protein sequence ID" value="CAE1229674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BH22"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1229674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="176" mass="19499" checksum="991CCD274B7A49AA" modified="2021-09-29" version="1">MFSLHLNTHSLSLSIASPFCTLKSLSSSFPILPSLSLSISPFVSPLSLSLSSFSTRSFDISHSISLSLDFFFLSFSLSLFPSLSYSLSFRRLKPLSLSLSLSFSFLSHFLSFPHPYFLILSRFLSFVFSFFFPSLSIFLSLSFSSAFSLSTFVSLFLSFAPSLSPPINLSILNTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BHD3</accession>
    <name>A0A812BHD3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_20194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000740">
        <property type="protein sequence ID" value="CAE1236361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BHD3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1236361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="240" mass="27489" checksum="ED19538A2D0F311F" modified="2021-09-29" version="1">MLFLFKCSFLSTSALVKPKTSFPVRSPSSSFFFRIFLFLFPLFFLPFNICFVFFSFCIIFFLFFAAFLFLSSSSSFFLSFFLSFFLSPHYITHDISVYFFHSLTFYSSHILSFSPFNFFSFSLSLFPLSFAFFSLLFSLSLSLSLFQFSFLFFIFSIFLSFRSLTLSLFSPSLTLSRTTSHPLSHIDSLSPSISPSLSLSHTFSHTRTNTLSHTHILSHILSNIDSLPSSISLSLSLSHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BHP9</accession>
    <name>A0A812BHP9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_16810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000596">
        <property type="protein sequence ID" value="CAE1228438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BHP9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1228438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="251" mass="29192" checksum="788F930A6019EFC1" modified="2021-09-29" version="1">MKKSIYLSIYLSICVDLFISIYLSIYLSIYLSQSVRISLYFSACSYLHIYLSIYLSISFSHLISIYLSIYLSISLICSHLPIFLSLFISPYLSIYLSIYLSIYLSIYQFQSFNIYLSIYLSIYLSISLSPFISIYQFRSFNIYLSISVLLISIYPFIYLSIYLSIYLSQSVLSLYFSAYISPYLSIYLSIYLSIYANFPGKIIALFMSSVSVLTLSRDFIFSRYLSRSLSVDPLEITLDCPERDKYFSVIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BIT4</accession>
    <name>A0A812BIT4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_18146</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000654">
        <property type="protein sequence ID" value="CAE1231545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BIT4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1231545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="176" mass="20319" checksum="776C355BEAE93749" modified="2021-09-29" version="1">MLLINLDISFILILSPFFIFFRHVFSFFCLILIFLFSFISFTYNFPSHLQFSLYLLSFFVYILLFIFLSCSSSNPIFLFIVFFFKRFSSSFPYIKDSFHFFLSCIHLSETVITVSSPDQFSPMELSGIELSSSVEKLNGLLMVTNHFLFENALLVSLADISESTKGANPLCSTLFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BMV7</accession>
    <name>A0A812BMV7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_18429</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000667">
        <property type="protein sequence ID" value="CAE1232246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BMV7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1232246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="216" mass="25698" checksum="21CF0C5861C305BD" modified="2021-09-29" version="1">MHCMICDRKEKTFLLLKKFHILRRKVTEFPPYLSIYLSITDIHLSLPLSLSRPPDRRYFSVCSCLSIYLSIYLSIYLSVFPPESVLYLSIYLSIYLSIYLILFISIYRSHSYHIYLSIYLSIYLFDSFNIYLSISICSYLSIDHILFTSIYLSIYLSIYLSIYLSYSVHIFLIPFISVSFFSHLSIYLSIYLLLFHIYISIDLILFITMYLIFISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BMY7</accession>
    <name>A0A812BMY7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_21820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000802">
        <property type="protein sequence ID" value="CAE1239496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BMY7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1239496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="241" mass="29336" checksum="D8C2B270546F6B38" modified="2021-09-29" version="1">MRLVYGVLFPFFFNSCSFPFFIHPSFFLSFFLNLSFHSLLCYKSLFSLFPYSFFLSFSFTIFFSFSYLILILRSCFHFLFFLPVFLSFFLFSFFFLSSFSFFLSFFLSFFLSFFLSFPFTPSLFPFSSLIFKFHYYFLFLNFSFRVSLSFFLSFFLSFFLSFFLSFLFTLSLFPFSSLILKLHYYFHFFKILPPVSVCLSFFSFFLSFFLSFLFTNLFRSLPSYDFTLLPFLFFIYLFTFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BQQ5</accession>
    <name>A0A812BQQ5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_21209</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000779">
        <property type="protein sequence ID" value="CAE1238167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BQQ5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1238167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="265" mass="31902" checksum="BC9AE2A75468AA36" modified="2021-09-29" version="1">MLIISDLKKGAKTSSQTTFLVFHATCSDAVSDSLSLAVSLLAFPFNFIVSLLYLSIYLSIYLSIYLSICFTFFFLSLFPFPFSFFFLFFLFLFLFSIFLFFFLFSFFSFSVLISFSLLSFRSTFSFFLSFFFRSYSVTFSFSFLLSFSFLFLAFFIYFSFFLFPFPFFFLSSYFFLSFFLRFSLSRHFFLSPVCIFFLSFYNVLSFFLSFFFRFYFSFPFSFLSFFLSFFLSFSIFLFFFLSLFHFSFFHSFFLFPFSFSLSFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BRQ4</accession>
    <name>A0A812BRQ4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_20461</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000749">
        <property type="protein sequence ID" value="CAE1236893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BRQ4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="359"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="384"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="428"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="464"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="490"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="521"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="554"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="582"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="636"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="665"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="688"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="723"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="747"/>
            <end position="771"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1236893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="784" mass="91265" checksum="920C926ECC636D5B" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BSE8</accession>
    <name>A0A812BSE8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_22076</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000813">
        <property type="protein sequence ID" value="CAE1239960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BSE8"/>
    <dbReference type="OrthoDB" id="2274644at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1239960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="254" mass="28594" checksum="E94F4364E2F414D5" modified="2021-09-29" version="1">MKPSLLSIKKTSVKPSPLYKDIYEPSLLSYKEHLKPSLLSIGTSSKPSLLSIKSIYEPSLLSIRHLKPSLLSIKDIYKPSLLSIKRHLTSINHLSSLYKDNYEAISSLYKSIYEAISSLYKDICKTVKPSLLSIRNIYETISSLYKDILSNHEAISSLYKDIYEAISSLYKDIINIFLSIKTSMKPSLLSIKTSPISSLYKNTSIRPSLLSIRSIYEPSLLSIKNIYGLSLLSIKTSEAISSLYKSNHEAISYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BSS9</accession>
    <name>A0A812BSS9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">POLE2</fullName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_23365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="EMBL" id="CAHIKZ030000866">
        <property type="protein sequence ID" value="CAE1242590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BSS9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="324"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="353"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="383"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="412"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1242590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="429" mass="52074" checksum="A6D25E5CB0088379" modified="2021-09-29" version="1">MTFSSFFLSFFLSFFLSFYLSFFLILFPNLFSFPQVFQSLLSFFLSFFLSFFLSFFLSFFNLSFFLSFFLSNFISQPFFPFLKFFNLSFLSFFLSFFLSFFLSFFLSFILSFFLSFFKFFNLFLSFFLSFFLSFFSPFLLSFFLSFFLSFFLSFFLSSFFLSFFLLFVCFFSFVCLFVCLFLSFFLSFFLSFFSHLSFFLSFFLSFFLSFFLSSFFLSFFLSFVCLFLFFCLFVCLFVCLFVSFFLSFFLSIYFTSVFYVSASVSVSISIYLSIYLSIYLSLSISLSIYNPFSLFHCSCLCINTRSFFLFSFLSLLMNLSFFSFFLSFFLSFFLLFVCFFLFFLSFFLSLFSFFVSFFVSFFCLFVSFLSFFLYFFSFFLCYFLFFISFFIFCLFFLCFFLCYFLFFPSFFLSFLMHFLSFFLSFFSLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BSV6</accession>
    <name>A0A812BSV6_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SPHA_21561</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000791">
        <property type="protein sequence ID" value="CAE1238872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BSV6"/>
    <dbReference type="OrthoDB" id="6115582at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000050">
        <property type="entry name" value="Titin isoform B"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052385">
        <property type="entry name" value="Obscurin/Obscurin-like_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35971:SF5">
        <property type="entry name" value="OBSCURIN LIKE CYTOSKELETAL ADAPTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35971">
        <property type="entry name" value="SI:DKEY-31G6.6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="69"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="156"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="270"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="348"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="437"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="552"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="562"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAE1238872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="607" mass="69907" checksum="18A4CA9AD7A74E11" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BSW6</accession>
    <name>A0A812BSW6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_23453</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000868">
        <property type="protein sequence ID" value="CAE1242722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BSW6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
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        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1242722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="259" mass="30145" checksum="779F7C6CC5C7A180" modified="2021-09-29" version="1">MHVSSIYLSIYQSIYVNLYRATLSLSLYLCFSQRNMQMILARTAALSPPWILMDKRLLPLCRCLLPVVKYNNSTHEVLQIFAASARVETRFTVSVPSCRFQLLTAVSDDVSSTHIDELLCNYIVVLCLSLFVMSFQEVSDYCSPRHPIIFILLIIISLRVFFLFDVKYFSNNIYLSIYLSIYLSIYSVNLKLAFRSHHTLAPALFSFYHYFYDIYLQVFYACFPIPVPVMIYLSIYLSIYLSIYLSIYRPKQNTIGSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BVD6</accession>
    <name>A0A812BVD6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_22419</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000829">
        <property type="protein sequence ID" value="CAE1240646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BVD6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="212"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1240646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="264" mass="25180" checksum="AC9A46F79E8667C6" modified="2021-09-29" version="1">MSGTSPLPSDIASTSPSTPAMSATSPLPSDIASTSASTPAMSATSPLPSDIAFTSASTLAMSATSTVPSDIASTSPSTPAMSATSPLPSDIASTSPSTPAMSATNPLPSDIASTSPSTPAMSATSTLPSDTAFTSASTPAMSATSPLPSDIASTSASTLTMSATSPLPSDIASTSPSTPAMSATSPLPSDIASTSASTPVMSATSPLPSDIASTSASTPAMSATSPLPSDIASTSPSTPAMSATSPLPSDIASTSASTPANVSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BXE4</accession>
    <name>A0A812BXE4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_24575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000918">
        <property type="protein sequence ID" value="CAE1245018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="313"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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    </feature>
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    </feature>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="931"/>
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        </location>
    </feature>
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        <location>
            <begin position="983"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1010"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1046"/>
            <end position="1066"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1245018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1535" mass="175324" checksum="A4C53CF0ABCF943F" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BXN6</accession>
    <name>A0A812BXN6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_23600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000873">
        <property type="protein sequence ID" value="CAE1243067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BXN6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="303"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="346"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="407"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="439"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="513"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="542"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="571"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="613"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="646"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="675"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="744"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="803"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="836"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="863"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="894"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="925"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="952"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="983"/>
            <end position="1003"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1243067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1043" mass="115627" checksum="1A5D55E9B309A81E" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BXT2</accession>
    <name>A0A812BXT2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_26070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000996">
        <property type="protein sequence ID" value="CAE1248238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BXT2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
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            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="263"/>
            <end position="285"/>
        </location>
    </feature>
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        <location>
            <begin position="297"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="426"/>
            <end position="453"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="460"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1248238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="480" mass="56958" checksum="6FC084808B40E9C3" modified="2021-09-29" version="1">MDPGKLCIPFFFFSRADQVLFFLVLIFIPCLLSFLSFFLSFLFFPFYKYGRLFYRLFYTFLRVFLLYHISPFPFYFCIHAFIALFRLSFFFVIFLICSFFLSLFLSFFLSFIHSFSVFLISLIISFFITLPFFYFVFLSSINFLSISFFLSFFLFFSFFLFFSFSFIQRTNFYYTLSLFSLSFGNCISRTYFCRTIYLSIYLSIYLYHLSIYPVLFSIYYHLSIYLFIYLSLSQSVHYLSFIYLSIYLSYLSIYLSIPSIHYLSIYLIYHYLSIYLFIYLSIYLSQSVHYLSIYLSIYLSIYLSIYLRLFTIYLSIYLSIYLSKGHHPVLHLPHPHCRYLQFRLRPLIDDDGCGGRSGEVTISFFAAALAGRTDFCISPFTVFSPPVFQVLSLPPACTAVVRDLFRLCRLFHYIFLSLSVSLPPSLSLSVGLSLCLSNTFLSLYILSIFFFYSKKHRMNISIYASICISLFIYLSIYLPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BY21</accession>
    <name>A0A812BY21_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PSMD12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SPHA_26220</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Farmed</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit p55 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001001">
        <property type="protein sequence ID" value="CAE1248547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BY21"/>
    <dbReference type="OrthoDB" id="268763at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000070">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054559">
        <property type="entry name" value="PSMD12-CSN4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040134">
        <property type="entry name" value="PSMD12/CSN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12/COP9 SIGNALOSOME COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22241">
        <property type="entry name" value="PSMD12-CSN4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="3">
        <location>
            <begin position="239"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAE1248547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="448" mass="51788" checksum="7C8001CDE384767C" modified="2021-09-29" version="1">MAAETGDGRVQKMEVDYSSTVDEKLPKCEKLAKQGNLVEAIDMLLSLEKQTRTGADTHSTSRILVAIIKMCFEANNWELLNEHIVLLTKKRGQIKQAVTKMIQEACSYVDKTPNQEIKLKLIDTLRTVTAGKIYVEIERARLTRILAKIKEDEGNINEAASILQELQVETFGSMDKKEKVEFILEQMRLCLAKKDYIRTQIISKKISTKFFDEADTTELKLKYYQLMIELDEHEGSYLAICKHYQAIYNTPAIQEDKDKMADALKCVILYLILAPYDNEQSDLLHRIGQEKNLNEIPKYKDLHNLFTTSELIYWKQLCADYETELKQGSKGCPATHVFSSKHPGSSKRWQDLKNRVVEHNIRVMAKYYTRVRMCRMAQLLDLSEDETEEFLSNLVVNKTVQAKMDRLDGIINFRQHKDPNSILNDWFFSLQITSHHQSDKFLSPSNSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BY73</accession>
    <name>A0A812BY73_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_26268</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001003">
        <property type="protein sequence ID" value="CAE1248722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BY73"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1248722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="265" mass="31456" checksum="9F9F65DD00772947" modified="2021-09-29" version="1">MKSIYSREVKQFYLLFFLPSFLPSFLPSFLPSFLPSFLPSFPLLSSKRNSPLFIRFLLSPPFLLSFFLSFFFLFFFLSSFLSFYHWKQVVKLNNSISSSFFLSFFLSFFLSFFLSFFLSFFLSFFLSFILSLKTSSEVKQFYILFFLSFFLSFFLSFFLSFFLSFFLSFILSLKTSSTVHIYLNFFSIGLSLCFDIYLSIYLSIYLSIYLSLFISIYLSIYLSIYLSIFIFISVHINLCSLSIYLLSIYLSIYLSIYLSIRLVQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BZ35</accession>
    <name>A0A812BZ35_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_26724</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001020">
        <property type="protein sequence ID" value="CAE1249670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BZ35"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1249670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="284" mass="33108" checksum="0022943EA3E3466C" modified="2021-09-29" version="1">MNELDDNANFILPAAQRTCYSICSFHVFHSLFVRTLAISLFLLSSLPFISSLSLSFSLSLSLSLSLAEVSGELHLFPSFFLSFFLSFFLSFFLSLSFLSSFHSFFLPAIIPYYIRLSFFLSFFLSFFLSFFIPCFFLSFLSNLPSFLPSYLPSFLSFFLSFFLSFFLSFFQPSFLPSYLSFFLSFFLSFFLPSYFTISLFVCGFPSFFLFCLLAFFLDSFLSLFPPFLSFFLSFFLSALILYYILLSFFLSFFLSFFSSYFLSFFIPSFFLSFFFACLLSFLIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C085</accession>
    <name>A0A812C085_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_25940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000988">
        <property type="protein sequence ID" value="CAE1247984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C085"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="325"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="355"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="402"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="437"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="466"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="499"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="529"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="569"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="609"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1247984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="689" mass="81814" checksum="4C5327A4CB050433" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C8L5</accession>
    <name>A0A812C8L5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SPHA_31480</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001293">
        <property type="protein sequence ID" value="CAE1258975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C8L5"/>
    <dbReference type="OrthoDB" id="6251061at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000130">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon opus-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055469">
        <property type="entry name" value="DUF7041"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23055">
        <property type="entry name" value="DUF7041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DUF7041" evidence="8">
        <location>
            <begin position="17"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase zinc-binding" evidence="7">
        <location>
            <begin position="489"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="183"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAE1258975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="672" mass="75916" checksum="27E848D7D11D3BD7" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C9X6</accession>
    <name>A0A812C9X6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_33909</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001429">
        <property type="protein sequence ID" value="CAE1263864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C9X6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="391"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1263864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="415" mass="49216" checksum="23F14CC24BD8C659" modified="2021-09-29" version="1">MLVPLSEQADACVSIYLSIYLSIYLSIYLSQSVHIYLSIYLSIYIYLFLHIYLSIYLSIYLSIYLLPTYLSIYLISSYLSIYLSIHLSMYLSQSVHMYLSIYLSLSVSSYLSIYLSIYLSIYLSFFFISIYLSIYLSIYLSIYFLNIYLPICLSFFISIYLSIYLSIYLNIYLSISVCSYLSINLSIYLYLSVSSYLSIYLSIYLSIYLSIYLPIYLSISSVHMYLSIYLSLSVSSYLSIYLSIYLCLFISIDLSTYLSQFLNIYLSFFISIYLSIYLSIYLSIYLSIYLSIYLFSSYLSIYLSIYLSIYLSIYLSKYLSSLFNHLANYLIFFLSFRICFIFLNYKNHRGFSTHLPNYYPRFFRFSVYLRIASFTNLGFSLLPYIQYITYLISPLLIGHLLHFSFLFFQSQRYKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CA80</accession>
    <name>A0A812CA80_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_35557</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001534">
        <property type="protein sequence ID" value="CAE1267352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CA80"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1267352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="197" mass="23871" checksum="87FD11B94A3E9A35" modified="2021-09-29" version="1">MLDNFRYFFFRSFLRIHYLIDCFLFNSHHLYCYIFFFLSFSFTTAICLSFLTVIQITFFFRIYRFVLLAIFVFLNDLLDSVFLSLLILFPANFTQFFFLFFFHFLNNLLTFLSPSLSLSLFPTLFVIIPVVMLYFLHSFLFISYSFHSFIFCLLFMIYLPDVSPSFILVLRSFFISIFLHSHLAFFSFFFIKLHCHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CAC2</accession>
    <name>A0A812CAC2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CRISP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_31237</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001275">
        <property type="protein sequence ID" value="CAE1258453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CAC2"/>
    <dbReference type="OrthoDB" id="737510at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018244">
        <property type="entry name" value="Allrgn_V5/Tpx1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01009">
        <property type="entry name" value="CRISP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032471514" evidence="1">
        <location>
            <begin position="22"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="2">
        <location>
            <begin position="52"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1258453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="339" mass="37716" checksum="BCE058049962E82A" modified="2021-09-29" version="1">MKASVLSIFVFLIICMTVSSALDCPIMFQGIKGHSACLAKSPDYVSGSISKEDINLILNEHNKYRASVDPPACNMLKVYWNDNLAYVAQKWAQNCKFSHDKFLARYIPGDFAAGQNLGKGFGSWSDCIAAWYNEKKDFIYNGTVTFAKVGHYTQLVWGTSSAIGCGYAKCKDFPIYVCNYGPSGNSQGSINRPYEKCNEKKPLKDCNGKFCKNDGAMKSDNCECNCKPYKHIYGPDCSVNCTAKDEALCQNVFDEKSCSFSNVPAMCPWLCKICPYLDQKKSENKTSPKPTTMWPYWSTETSTIQSSKTTWPGSSGTAVFKHSMMSTLSLMMLILMVLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CDM8</accession>
    <name>A0A812CDM8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_33344</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001394">
        <property type="protein sequence ID" value="CAE1262635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CDM8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1262635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="188" mass="21181" checksum="1CFE3DD42860885D" modified="2021-09-29" version="1">MLGAYLNLFERGGGERNSSRNSEETEQKEWADLLLSLTLSLSLSLSLSLSLSLSIYLSIISFKKNTTQNEWADLLLRLILSFPPSLFFSLSISTYLSIYLSIYLSIYLSIFSFVTYRISTCPLERRIQKEWADLLLQITLSLSPPLSLSLSLSLSLSLSLSPLSSLLLRIGFPLVLSIYLSIYLSIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CE19</accession>
    <name>A0A812CE19_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_37532</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001671">
        <property type="protein sequence ID" value="CAE1272109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CE19"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1272109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="180" mass="20162" checksum="1C076E25FEE25C8E" modified="2021-09-29" version="1">MASLLISTYPSVHFSLPYSLPSQLPTPSTVHLLIYLCKSHVPCPAYGYPVPVGGLSVSFIPFIWFDFIRPTKCPITLDILSLSLSHTHTKYLSFSLSFYLSFFLSLLNLFLSLSISLLSPHKCLFLSLLLSFFFLLEDFSLSLSLSTSLFSLFILSQISLFSLLSYSLLLFLPLSLNLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CL82</accession>
    <name>A0A812CL82_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_37409</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001668">
        <property type="protein sequence ID" value="CAE1271798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CL82"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1271798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="259" mass="30098" checksum="0E15ED4883ACFC9B" modified="2021-09-29" version="1">MRDSRKYFSCSIYLSIYLSIYLSIYLVLIKQLFFPFLLFFLTSLIYLSIYLSISLFFSFTNTVCLSLLSPHTPSSHLSSFITDFVSFFLHPKCSPISPRLSLCLPILQFLLSLSLYHSFSFSLLLPFLLLSFSMPYNLSLTFSTCYHYHLSLSFSPLFSLHVTLSFSLSLALFRSLSFYIFLFFYFALSFSSIIIILSTTTSSLFPSLLIFLLSDCLFPSLYFYISSISSHSISFFLFFLLFSYYFSSYISFFSLSLFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CN93</accession>
    <name>A0A812CN93_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_38563</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001757">
        <property type="protein sequence ID" value="CAE1274014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CN93"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21698">
        <property type="entry name" value="PROTEIN (PUTATIVE)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21698:SF4">
        <property type="entry name" value="PROTEIN (PUTATIVE)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1274014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="254" mass="29309" checksum="D2231D414BF4C9F5" modified="2021-09-29" version="1">MSVCNKHFISIYLSIYLSIYLSIYLSVSLSVINSSYLSIYLSIYLSIYLLSVINSSYLSIYLSIYLSVCLSVINSSYLSIYLSIYLSIYLYVCNKLFISIYLSICISVCNKLFISIYLSIYLSIYLYVCLKLFYLSIYLSIYLSIYLSIYLYSVCNKLFISIYLSIYLSIYLSICKSVCNKLFISIYLSICMSVCNKLLSIYLSISMSVCNKHFISIYLSIYLSVSLSVINSSYLSIYLSIYLSIYLSIFPCFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CS71</accession>
    <name>A0A812CS71_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_42434</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002079">
        <property type="protein sequence ID" value="CAE1280644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CS71"/>
    <dbReference type="OrthoDB" id="6038825at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1280644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="214" mass="25267" checksum="A053A122F6054941" modified="2021-09-29" version="1">MLVPEMSFSDFKFVYADLKLIYLSIYLSIYLSIYLSIYSHILNFRDTIYLSIYLSIYLSIYLSLSLSLYIYIYIYREREREREGERNRECRKVDSLTIVATASRSAKIPSLNQRRIAFLKIRSAESRKWTVLVDATLSGEVIVSGLRPDLLLIDSKKKRQLLGKLTVTWEEKIEEAHKRKLLRYEKLVAEVRERVTAARWCRLRLAVQDILLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CW67</accession>
    <name>A0A812CW67_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_41307</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001979">
        <property type="protein sequence ID" value="CAE1278534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CW67"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1278534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="219" mass="26811" checksum="431FD374E147908E" modified="2021-09-29" version="1">MTLSSFQRTCQFECVSSILICLSFIIFSVFSFFLSFFISLFLSFTPQVIFCSDLYFISILSSTAYTFFLSFFLSFFLLHHTWYSPILSFFLSFVRSSFFLSFFLSLFYTTWYSIFIFLLFYIYSFFHPFFIPSFLPSFLPSFLPSFVFFIINVSFIYFLFLRSLFLLSTFTSYNFYFFCLYSLYQYFLYKMCIFLYLQNIFFFHSYFSFTIYLFYYLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CYJ7</accession>
    <name>A0A812CYJ7_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Eukaryotic peptide chain release factor subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SPHA_43846</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic release factor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002223">
        <property type="protein sequence ID" value="CAE1283070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CYJ7"/>
    <dbReference type="OrthoDB" id="10254527at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000009">
        <property type="entry name" value="Eukaryotic peptide chain release factor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.60:FF:000001">
        <property type="entry name" value="Eukaryotic peptide chain release factor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.960.10:FF:000001">
        <property type="entry name" value="Eukaryotic peptide chain release factor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.960.10">
        <property type="entry name" value="eRF1 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.60">
        <property type="entry name" value="eRF1 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042226">
        <property type="entry name" value="eFR1_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024049">
        <property type="entry name" value="eRF1_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005141">
        <property type="entry name" value="eRF1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005142">
        <property type="entry name" value="eRF1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005140">
        <property type="entry name" value="eRF1_Pelota-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004403">
        <property type="entry name" value="Peptide_chain-rel_eRF1/aRF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03676">
        <property type="entry name" value="aRF1_eRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10113">
        <property type="entry name" value="PEPTIDE CHAIN RELEASE FACTOR SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03463">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03464">
        <property type="entry name" value="eRF1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03465">
        <property type="entry name" value="eRF1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01194">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55481">
        <property type="entry name" value="N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eRF1/Pelota-like N-terminal" evidence="6">
        <location>
            <begin position="102"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAE1283070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="551" mass="61730" checksum="54F9D380AEA46F0F" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CZQ9</accession>
    <name>A0A812CZQ9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_44882</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002301">
        <property type="protein sequence ID" value="CAE1284644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CZQ9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1284644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="160" mass="18517" checksum="4883951FD99818A1" modified="2021-09-29" version="1">MSTALRTRAKTFSSSSLSPSLSLSPSLSLSVSLSLSVSLFSFSCITVFLYSLPSTSIFLYRFLLFFPLQLLSYFIYTFFFSHIFHSDSLTHCLFLTISYLSLSLPSYFYFLFPLPPLFITSILILNKLLSFRTKYCSLFLFSFFLPYLLLLFFLLFSSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D3F3</accession>
    <name>A0A812D3F3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_45383</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002335">
        <property type="protein sequence ID" value="CAE1285340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D3F3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1285340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="225" mass="26841" checksum="7290192291C67271" modified="2021-09-29" version="1">MIFSVVSGFRKYLNEKMSFLYKEFSFFLCHFNTFYCLSVFYFHTISLYITSFFSSLCLPVSLPAFFFLSFYCLSLHLLFSYYFALYHFFLSLFITFFLPSFLSFGLSVYRLYFFSLSFCHSSFFYVFLSICLSLFFLSLISSFFPLLNLHAISLLVLLLFSFLYLYFFPLVYLSFSFSFHMVFASVFPIHSPSPFSFFPSYLQCTRFPSFRRRFSPCLLFKSSYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D4J0</accession>
    <name>A0A812D4J0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_49776</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002888">
        <property type="protein sequence ID" value="CAE1293397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D4J0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1293397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="202" mass="23606" checksum="0AD7DE95A81D540B" modified="2021-09-29" version="1">MLFFPPFPSSSFTHSPFPPLPLTYILLTFLFFLPPPPYTFSSYSLLYTTPPYTLFSYSFLSAIPFFPLYPLLLLTTSPYIYLFYFPLLSTTTLHVFLLLSSLYHSPLHFFSYSFFFTIPFFPFYPLLLLTTSPYIYLFYSPLLSTTTPLHVFLLLSSLYHSSLHFFSYSLLILLLPITLFSPTLFFFLPLPLTFFHSSLLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D4W6</accession>
    <name>A0A812D4W6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_47368</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002557">
        <property type="protein sequence ID" value="CAE1288902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D4W6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1288902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="252" mass="29803" checksum="4CDB9BCDB4BDBDA3" modified="2021-09-29" version="1">MKTCNRYLFCFYSPSCLFNFLSLSFAFYICFLFSSFQLCCVFFVFSLSVHKFTSSSVIHLAFLSFRLSFVLSLLPSFLLYLFSFIFFFLFISFMTCYFYYFFSSCKFFYFFAHFRIVLFFLSFFLSFFLSFFLSFSFKYACPDFLYSFFQIYFFRTFLEIVFELCTFLSFLKSTYTGSAEEAGACHRETAPSKESLRLQNQQEHNRHGVCSPAAAGKMLGENNGTYVVFIDLTKAFDSEQKRNVADHRANRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D8G9</accession>
    <name>A0A812D8G9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ATG4</fullName>
            <ecNumber evidence="13">3.4.22.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SPHA_49138</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Farmed</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[protein]-C-terminal L-amino acid-glycyl-phosphatidylethanolamide + H2O = [protein]-C-terminal L-amino acid-glycine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine</text>
            <dbReference type="Rhea" id="RHEA:67548"/>
            <dbReference type="Rhea" id="RHEA-COMP:17323"/>
            <dbReference type="Rhea" id="RHEA-COMP:17324"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:172940"/>
            <dbReference type="ChEBI" id="CHEBI:172941"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:67549"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.-" evidence="13"/>
    <dbReference type="EMBL" id="CAHIKZ030002782">
        <property type="protein sequence ID" value="CAE1292188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D8G9"/>
    <dbReference type="OrthoDB" id="2960936at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019786">
        <property type="term" value="F:protein-phosphatidylethanolamide deconjugating activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035973">
        <property type="term" value="P:aggrephagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:autophagosome assembly"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005078">
        <property type="entry name" value="Peptidase_C54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046792">
        <property type="entry name" value="Peptidase_C54_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22624:SF52">
        <property type="entry name" value="CYSTEINE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22624">
        <property type="entry name" value="CYSTEINE PROTEASE ATG4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03416">
        <property type="entry name" value="Peptidase_C54"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peptidase C54 catalytic" evidence="12">
        <location>
            <begin position="703"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="111"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="211"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
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            <begin position="318"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
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            <begin position="377"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="448"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="550"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="119"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="170"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="235"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="331"/>
            <end position="340"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="352"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="377"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="398"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="416"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="470"/>
            <end position="487"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
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        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
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            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="595"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03416"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAE1292188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1083" mass="118968" checksum="D851A5CD1D9933D8" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D8Z8</accession>
    <name>A0A812D8Z8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">NMUR2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SPHA_49666</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002873">
        <property type="protein sequence ID" value="CAE1293196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D8Z8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF224">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 19-RELATED"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="16"/>
            <end position="34"/>
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    <feature type="transmembrane region" description="Helical" evidence="8">
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        </location>
    </feature>
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        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAE1293196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="161" mass="18435" checksum="CB47BCAC76913515" modified="2021-09-29" version="1">MAYAYPYRLFAKIQKFVTYYYCVSSAFVLLTISVERYFLVCRATKAQMTSTQARLLVGIIIFISGLLVIPVTVSFDMASLSLTPNVTITQCYFRHTPLAWAYYVSLFPANLTILILMFILYYQVEKQLVNICPKGQSETSTEQQPISIQFGICLQKETHSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DCS3</accession>
    <name>A0A812DCS3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_51699</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003148">
        <property type="protein sequence ID" value="CAE1296889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DCS3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="333"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="492"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1296889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="525" mass="61583" checksum="7402B208B39383A7" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DD40</accession>
    <name>A0A812DD40_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SPHA_51495</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003120">
        <property type="protein sequence ID" value="CAE1296508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DD40"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
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        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
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            <end position="65"/>
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            <end position="100"/>
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            <end position="132"/>
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            <end position="157"/>
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            <end position="198"/>
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            <end position="387"/>
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            <end position="429"/>
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            <end position="462"/>
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            <end position="490"/>
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            <end position="514"/>
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            <end position="609"/>
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            <end position="730"/>
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            <end position="764"/>
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            <end position="799"/>
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            <end position="828"/>
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            <end position="857"/>
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            <begin position="558"/>
            <end position="831"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAE1296508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="877" mass="105086" checksum="59D494A6007B6621" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DG14</accession>
    <name>A0A812DG14_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_52212</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003220">
        <property type="protein sequence ID" value="CAE1297752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DG14"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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            <end position="133"/>
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        </location>
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            <end position="357"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="484"/>
        </location>
    </feature>
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            <end position="540"/>
        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAE1297752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DG65</accession>
    <name>A0A812DG65_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
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            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Li R."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
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    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1302703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="189" mass="22950" checksum="B2F3893A2B5933D1" modified="2021-09-29" version="1">MHCFIQFFISVFLFFLSILVVVVVVFLSLRFIFFIPFFVFVSFLFSFILSFFPSFFLSFFLSFHFFSFFLSFFPFLLFLSFFLSFFLSFFLSPLSFFLSFFLSFFLSFFSIFVSFFLSFFLSFFLSFFAHISHFFPFFCFLFSFPLSFSCIPIFFLSFFLSFFLSLSFLLFLLNILDNNHCIIYYSFYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DIY4</accession>
    <name>A0A812DIY4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_53869</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003443">
        <property type="protein sequence ID" value="CAE1300390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10693232at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        </location>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="5518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5530"/>
            <end position="5549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1300390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="5550" mass="613656" checksum="0906957B18986D4A" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DKC8</accession>
    <name>A0A812DKC8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_57611</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
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    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
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        <dbReference type="NCBI Taxonomy" id="158019"/>
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                <person name="Li R."/>
                <person name="Bekaert M."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
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    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DME1</accession>
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        <submittedName>
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        </submittedName>
    </protein>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="5" xmlns="https://uniprot.org/uniprot">
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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    <name>A0A812DPU3_ACAPH</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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                <person name="Bekaert M."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">Farmed</strain>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1307986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="426" mass="50252" checksum="DCBABAD0B5613B90" modified="2021-09-29" version="1">MFIFQQRFLLQAVLTAARLFRRCLQVQRLVALSKILFVCFFLSFFYGHLYFFLFFIYLSIYLSIYLTDTQTSPLKTINRYISELIKRVMSVSFVLDDMFSSTYLASEIHKNTIYLSIYLSIYLSIYLSTDPLSFLTCRNHSRVIIIQIYPLASFNIFISRHHSKFYFPIIVQYFPFSTSFSIFFYRHYSKIFLSHHSIFFSPLIIQNVPFPVVIKYFPLSSLFKNIILSPSFNIFLSLHRSKHPSLAIIQYFPLPSSFKISFSRHHLIFSSPFIIQNIPPSPSFNIFLSLHHSKYHSLAIIQYFSLPSSFKISLSRRHSIVFSPFIIQNIILSPSFNIFSPFIIQNIPLSPSFNIFLSLHHSKYHSLDIIYYFPLPSSFKCFFSHRLTFSSIIIQQFLSSIIIQHFPLALSFKFSSHIFVQYFILQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DR92</accession>
    <name>A0A812DR92_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_60945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004269">
        <property type="protein sequence ID" value="CAE1309157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DR92"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1309157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="207" mass="24112" checksum="EE56052252B4AC0A" modified="2021-09-29" version="1">MTTLTNPKTTHYLSLSLSLSLSIYLSIYLSIYLSIYLCICYLSIYISPTLFTSYISTFPVQVPLSHFLFLSEFLRKFYLQISVQQPLSLSLSFSLSFSLSLSLSKSSFKGFKISKSSSNVTFFFIIIFHFLLFSISFVFLHCSTSYFLPIIHPDLFFIFSFYLFIHYFPIFLSFLFNFPSYFCYGFPFFPALPKSVSFSSLFFFSAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DW13</accession>
    <name>A0A812DW13_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_62566</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004482">
        <property type="protein sequence ID" value="CAE1311074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DW13"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="387"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="410"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="438"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="465"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="495"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="524"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="553"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="581"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="605"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="633"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="659"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="685"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="740"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="764"/>
            <end position="791"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1311074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="795" mass="94839" checksum="60B52069ECF49427" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DWT7</accession>
    <name>A0A812DWT7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_62221</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004429">
        <property type="protein sequence ID" value="CAE1310691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DWT7"/>
    <dbReference type="OrthoDB" id="3938623at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="265"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1310691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="284" mass="33158" checksum="B35B8612C641F575" modified="2021-09-29" version="1">MHLSDANSEEEDPCIEIDVLDESEDKCSVLEMEKKSIEAAALAGVTEETVDSTSRAVAMISENKNRQDGFNDKKLTDSVLQLDENSTQQQQSSLQQNTYHYHSNSHHHQHHHEQQHQRLQQQQQHLHLKEEECDEELKVDAKTERESKECKELYRSSFNRTSLDDLEQQPTFDETDCDLIPCNTVDVIQSHSPAPDILSMTKEQLHEQLIQEIKSRRKIEKECQTIKETFQEQVNTFSFSVIFLFIFNVLPSLFFFLFVFYLSLYFLHPFTFIVLSLPLVFLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DYQ1</accession>
    <name>A0A812DYQ1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_61007</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004279">
        <property type="protein sequence ID" value="CAE1309266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DYQ1"/>
    <dbReference type="OrthoDB" id="8121869at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1309266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="324" mass="35616" checksum="B5C5959A93B4D137" modified="2021-09-29" version="1">MNEIQDFLAERVISSIEGPWHIFSFPIHERFPAIFQLAVHLENGVLRYFSADTAMDVVACNKDTTLTASSKLCKQDEFARTLLYSDVRSYYVWTNKDTWAGGSAGVRGQLRGLSRCQKKRHAWKGINGPPLKPSRRPRIHKRSVPPACPGKLPTGFCYDQGSRINTQAASTASASRASETHHQRLVRNVRNAAATATSRAIETLDRRRAHQSRDAAATESARAAVTQLRRSCRNARNTATTAMSKHLTAGAPVNPGTLLQQLGRGSCSGQHAMPATLQRRLLPKTRANRLSRAAINIAAVALISNSPSSPHTPRRQHSTPCCRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DZH1</accession>
    <name>A0A812DZH1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_63134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004529">
        <property type="protein sequence ID" value="CAE1311790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DZH1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1311790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="181" mass="21702" checksum="C313748E7B71E855" modified="2021-09-29" version="1">MIPKWPTTKSIKLFFCRKQGVLVDRLPRWPRYISLFRKRPPKLRLRRNEHNISRCLPYLPVSIFSGSKLLRFSASHRFSSTVLFLFSFTFFFILHFLFFFLSFVFSFTLDLAFPVFCMRKFNAFLCIANVFHVFSQIMHYSPFFFLTLIEYNIKTSSLSLGYFFFSLLFFLSFLSSSFLVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DZZ1</accession>
    <name>A0A812DZZ1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_61831</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004391">
        <property type="protein sequence ID" value="CAE1310161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DZZ1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1310161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="201" mass="24527" checksum="32820C4D38F51802" modified="2021-09-29" version="1">MHFYSIYLSIYLSIYLSIYLSIYLYSYLSQSLPIYLSIYLSIYLSIYLSYTILLYLYLSILLESYVCMYVCMYVCMYLFQSIRIYLSIYLSIYLSIYLSIYPILLYSYLTILLETYLSIYLSIYLYIYIYIYIYIYIYSIYSYLSIYLSIYLSIYLSIYLPYSISFFLSFFLSLFLSFFLSIYLSIYLSIYLSSKIKMYCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E0L0</accession>
    <name>A0A812E0L0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_65648</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004725">
        <property type="protein sequence ID" value="CAE1314648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E0L0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1314648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="252" mass="29313" checksum="6F7E7895BE29DBA3" modified="2021-09-29" version="1">MSFVNPFYIVRLYADRYVSISIYLSIYLSIYLSIYLSIYLSISVCLLSIYLSIYLLSQSAHYLSIYLSQSIYLSQSAHYLSIIHSSIYLSIYLSIYLSQSVHIYLSIYLSIYLHFPICFQVYLVFSIIFFSLSPPTLSSLLSISRLSLFLFIPIHLSIYLSIYLSICLFHLSIYLSIYLSIYLILFTSIYLSIYLSIYLSIYLSIYLSKPASLPTFNDIPIFSFFSFLPFSTFNLPDFPRHPTPKIGSRMDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E2P9</accession>
    <name>A0A812E2P9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_66957</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004834">
        <property type="protein sequence ID" value="CAE1316201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E2P9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1316201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="280" mass="33709" checksum="B20505DF7B164076" modified="2021-09-29" version="1">MTVFDECLYLSIGNDLSQFGPWTVYRSVINFLSFFLSFFLSFFLSFFLSFFPFVISSFINFLSFFLSFFLLSIYLSIYLSIYLSIYLSVHALFGHLLIFFLSFFLSFFLSFFLSFFLSFYFSFFLSFFPFVISSFINFLSFFLSFFLSFFLSFFLSFLSSFYLSIYLSFILSMLFGLIFLSIYLFFLFHSLFLHFRHLLFFFLSFFLSFFLSFFLYFCSSIYLSIYLSIYLSIYLSITVYSLSIYLSIYLSIYLSIYLVQYIPYLSIYLSIYLSIYLSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E6U8</accession>
    <name>A0A812E6U8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_69548</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005089">
        <property type="protein sequence ID" value="CAE1319122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E6U8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1319122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="265" mass="31168" checksum="02A55EBCDF234CD1" modified="2021-09-29" version="1">MTIQSQSVFLSFFLSFFLSFFLFSPNLYLSIYSVPIRIFLSFFFFLSIQSPYLSIYLSIYLSIYLSIQCQSLSFFLSFFLSFFLSIRSQYLSIYLSIYLSIYTWFLICLSLIEKSFFYIFIQSLVYFSFSIPSLAIIQPVVNHIYSPQGRSATSSYLSIYVFNTYLFISIFPVSIYLSIYLSIYLSIQCQSLSFCLSIYLFNTYLFICICMTIQSQSFFPACFLSFYSVPISIYLSIYSVPNNFYLSIYLSIYLSIYLSIYLHCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E757</accession>
    <name>A0A812E757_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_68342</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004974">
        <property type="protein sequence ID" value="CAE1317824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E757"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1317824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="240" mass="27216" checksum="45A51FBC91FFEFC0" modified="2021-09-29" version="1">MTERPSLWKRLGKRRALKRGVIESVRLSLSLSLSSVNATSDKSLRHFFFFQPKQLTEWKKIKLYNSFSPLFSSSFSLNIPPPTLCLSLPLPLSLALLFFLPLFSPSPLSITHTHSNVPSLLRFLLPPVSHSHLHPLSLTLKPPPTFPLSLSNCPLTFNIFLTTSFPFSPSPTVHLPLLFSPVALFHHPPMFTILQPPLFPTSPSPPKSSEAARVPPDFYDQIKKHFHNLYLYFIYLHLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E775</accession>
    <name>A0A812E775_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_65680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004725">
        <property type="protein sequence ID" value="CAE1314659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E775"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1314659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="354" mass="42165" checksum="E15AF57F9E5B0ED0" modified="2021-09-29" version="1">MISRGRINIYTTVKLREIRNAQVSNQMISRGRIYIYTAVKLRETRNTHVSNQMISRGRIYIYTTEKLRETRNTQVSNQMISRGRIYIYTAVKLRGTRNTQFSNQMISRGRINIYTAVKLRETRKTQVSNQMISRGRIYIYTTAKLRETRNTQFSKKMISRGRIYIYTEVKLREPRNTHVSNQMISRGRIYIYTTEKLRETRNTQVSNQMISRGRIYIYTAVKLRETRNTQVSYQMISRGRIYIYTAVKLRETRNTQVSNQMISRGRIYIYTTEKLRETRNIQVSNQMISRGRICIYRAVKHRETRNTHVSNQMISRGRIYIYTTEKLRDTRNTQVSNQNDQPRANLYLQGGETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E848</accession>
    <name>A0A812E848_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_69630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005098">
        <property type="protein sequence ID" value="CAE1319187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E848"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1319187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="217" mass="26040" checksum="E82A4BEF3F735699" modified="2021-09-29" version="1">MFSHSLSLFSLSLLFMRFPCFTFTFFIFFLIFFMCLIIVDLSCLRFHSFASFFVFSCYIFIYLFIYHLCFSFYFFIVLFLFFLPYIHIYLSIYLSIYLSIYLLFAIVILSIFLSVFLFVLSFIIGFPFYPYPCCFCIVLSSLFFVSFIFLPLFLFPSLFIVFFFFSSLQLTFSSFFFHIIFMPVCFLLPFSSPFFIIPPPFHNLVFEISYLSKSFTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E919</accession>
    <name>A0A812E919_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_69374</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005072">
        <property type="protein sequence ID" value="CAE1318956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E919"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="287"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1318956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="354" mass="41607" checksum="725AB2DC6D3CFD4D" modified="2021-09-29" version="1">MDVRTMNSITLLTSPVSTHPPPPRHYHFCLSSFFARFQIPRLLFHDRCFPVSCCRRIKRIYLTLPTNLPTFVTYYLSIYLSIYLSISQCFDLNLFILSCSFLSFFFLSILLRFKYFFFFLGRPFISIYLSIYLSIYLSIYVCLDLSIYLSIYRGIFISIYLSIYLSIYLSIYLSKSVSICIFPVQIYLSIYLSIYLSIYLSICLSIYVCLDLSIYLSIYLSIYLSIAVYSYLSIYLSIYLSIYLSIYLSLFQSVSFLFRSIYLSIYLSIYLSIYLSRLLTRLHTYSIYLSIYLSIYLSIYLSQSVSICISQSVQIYLSKFSSIYLSSDLSIYLSIYLSIYLLWSGSLYHGDSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E9A3</accession>
    <name>A0A812E9A3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_66770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004818">
        <property type="protein sequence ID" value="CAE1315941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E9A3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1315941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="237" mass="28744" checksum="5BE24953653990BE" modified="2021-09-29" version="1">MVCSHHSTALQFLHFEVLSIYLSIYLSIYQVAVQISAFTQLNQTSHKFRNRVVIVDVIFFFFFFFFFFFFFIKSILFIQIFTLFFVFSLLRYHSLFHALCFFLSPSTLSFLTKSICYLFSFHFLLFFFYVFFLILFSSFPFPFLILCQLFTLFLILFLLFQPFPSFSSSFFSFFFFFFSHFLLFPRLFSYSFSSFLAFSFFFLVFLFQIFNPFSHSFSSFSVFSFVFLFSFLVLFLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E9B4</accession>
    <name>A0A812E9B4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_66780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004818">
        <property type="protein sequence ID" value="CAE1315955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E9B4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1315955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="302" mass="35960" checksum="9CA2E499C9631EAC" modified="2021-09-29" version="1">MDCLFTDFHRILFISIYLSIYLSIYLSISVCSYLSIYLSIYLSIYLSIYLSNLSLYISIYLSIYLSIYLSIYLSPLHLLKISGERKNWIISIYLSIYLSIYLQYLLGFDFSWLLDNCAFLISPSKYIYLFFSHLFVLSFLLFFLISNSFLFSTNFVYFSISVLCRTDVRSFCLFVCLFLFPCKCPLFFLYHWSVHKLPSSFPSFLLSFFLSFFCITFLSLFLFHCPLYKLTSFFLSFFLSFFLSFFLSFSTHLFHTSSDMIHLHFFHFDSLIVLCTNYRLSFFLSFFLSFFLSFLLAEAFPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E9I7</accession>
    <name>A0A812E9I7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_70227</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005136">
        <property type="protein sequence ID" value="CAE1319961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E9I7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032275469" evidence="2">
        <location>
            <begin position="25"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="295"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1319961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="343" mass="38519" checksum="D4DE3EAD7C6D3953" modified="2021-09-29" version="1">MPSSPYSFSFALLLLLLLPFLLISSPCFLFFCSPPHPLYSFALLLSPFFSPLPTFLLFSSPSPFFALPFPLFCSPLPHFSFALLLLHYNCALPTISFFICSSSSSPPPPPFSFNLLSSCSLFICSPPHPLFFLLFSSSSLFFALLLSPFFLSSSHFSFALLLSPIFCSPLSLFLLLFSSSITIVLSPPYPFSFALLLLLLPFLLISSPLAPFSFALLILSFLLLSSSSLFFCSPPPPFCYSPLPPFLLFSFSSSLLLLLSSLFYLMESFILLLSSSSPHFTAPLFWDPLSPFFRCVLFFHFFFLSTSHFFSSSYLYFSSSSPLFFFFLYPPPFFCTSFLLVFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EB20</accession>
    <name>A0A812EB20_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_69353</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005072">
        <property type="protein sequence ID" value="CAE1318958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EB20"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="313"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="349"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="397"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="431"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1318958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="453" mass="55250" checksum="05409C31EF3A557F" modified="2021-09-29" version="1">MFRSFIELIHYVFFLLSYVLCFGSTRLSFFLFLHFNFILPFFLSFFLSFFLLVFFLFFFHFFSLQNLRRHFQQLLYPFFLSFFLSFFFFIILSNHYILSFFLSFFLSFFLPFYLSFFTFSFVFVCFFLSVGLFLFAEFTSSFLETFIYFLSFFDFCFFFSFSLTFPLFGIYVVILSYYYILSFFLSFFLSFFILSIIYLSIYLSIYLSIYLSIYLSHFVFLCFSLFFFLFYTIYLSIYLSIYLSIYLSMNVRIYLSIYLSIYLSIFIYVCMYVTLYLRRYLSIYLSIYLSIYLRMFISIYLSIYLSIYLSKEIFFRSMSVCLSIIYLSIYLSIYLSIYPHLYMYIYLSIYLSIYLSIYLSIYLTLFISIYLSIYLSIYLEKEILLDLSIKDLLDLSIYLSIYLSIYLSISLYSYLSIYLSIYLSIYLSIPLYSYLSIYLSIYLSIYLSIYLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EDQ9</accession>
    <name>A0A812EDQ9_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="10">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SPHA_73320</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Farmed</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 10">Belongs to the E3 ubiquitin-protein ligase UBR1-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="10"/>
    <dbReference type="EMBL" id="CAHIKZ030005372">
        <property type="protein sequence ID" value="CAE1323437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="15304at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071596">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the N-end rule pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd19673">
        <property type="entry name" value="UBR-box_UBR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.30:FF:000002">
        <property type="entry name" value="Putative e3 ubiquitin-protein ligase ubr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044046">
        <property type="entry name" value="E3_ligase_UBR-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039164">
        <property type="entry name" value="UBR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055194">
        <property type="entry name" value="UBR1-like_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003126">
        <property type="entry name" value="Znf_UBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497:SF39">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497">
        <property type="entry name" value="UBIQUITIN LIGASE E3 ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18995">
        <property type="entry name" value="PRT6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22960">
        <property type="entry name" value="WHD_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02207">
        <property type="entry name" value="zf-UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00396">
        <property type="entry name" value="ZnF_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51157">
        <property type="entry name" value="ZF_UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBR-type" evidence="12">
        <location>
            <begin position="96"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="UBR-type" evidence="9">
        <location>
            <begin position="96"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="967"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1086"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="967"/>
            <end position="980"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAE1323437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1819" mass="206661" checksum="4A2E969E2BD3751F" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EDU6</accession>
    <name>A0A812EDU6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_70435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005157">
        <property type="protein sequence ID" value="CAE1320170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EDU6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1320170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="154" mass="18577" checksum="7AE9FCAFE76DC4E8" modified="2021-09-29" version="1">MKPDPNRGRRDFLPFFYLSIYLSIYLSIYLSIYLSISLYIYIYIYIYIYIYIYLLIIYLSIYLSIYLSIYLSIYLNLFIVYLSLLPIISSSVFGHLLIFFSLLSLIIFTTFLKTLPTFLYYFSFSLFTCFLPVVHSYFFLCFESYIPPSFCYSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EGB8</accession>
    <name>A0A812EGB8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_71807</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005267">
        <property type="protein sequence ID" value="CAE1321752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EGB8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1321752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="264" mass="30528" checksum="D0A58F72531FD3BD" modified="2021-09-29" version="1">MSLSYLSIYLSIYLSIYLSIYLSIYLSIYLSIYVSCFVCPLYPHLYYLSIYLSAIFSHLWPQLFFPTSGHYLSNRLNCIRGTDLRYMIPFFITSIYLFFFLLLSICRSFIYLSIYLSIYLSIYVFSNSIYLFPFFFLSPFDFYLGISLYLSTFDIYLSIYLSIYLSIYLSAFVLYAAVTRGVSRPVAGTNSLSLSLSAVVSRRSVFIDPRTWGVRRSGYASVPKNPIRALSENVQICGTPPPPWNSTWAFSLFCSPDQTRFLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EHC8</accession>
    <name>A0A812EHC8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_72353</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005313">
        <property type="protein sequence ID" value="CAE1322366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EHC8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1322366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="301" mass="34443" checksum="CD93E5FB0D56678B" modified="2021-09-29" version="1">MHFSVCYPLFPYAFCSIAFFFLSSFSISLSILVISFLVYYFHSSLYFCSPFISLSELFSLFFIFGVFSFPLLLFLRQSFSFLSSFSTPTFSIFFPSRFFFLYVGLFPLSVHLSPCRPFSFSSSSLSTIFHFFFLSIGFILFPLYLLSPFFYFSFSFPMATIFHSFFFSSNGLLFLFSPYRRSFFNILLSVGFLPFTLLFPSGRPFSFSFSFSQVTFSLSPCRNSSSIFLSLRRPSFSPQFFLPIDCLPFLLLLPLVFSLPFFSGLLSPSSPPSPSALSFVPLSLYSRKLNGINASDFLSCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EHS6</accession>
    <name>A0A812EHS6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_73867</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005398">
        <property type="protein sequence ID" value="CAE1324073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EHS6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1324073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="245" mass="28555" checksum="2BC42D97212F3789" modified="2021-09-29" version="1">MCAKTIEGYRCQITTPPRHVTSASCILYPLTLLCPTLACPEPFEPLIFFLSFFLSFNASFLSFLFFLSCCQCHFSLSFSSFVFFLSFLSFFLSLNVFSLLFRFVSFFLSVLFSFSFPSFSLHIFFLFPFSLSFPPFLSASSLPSRLYLSIYLSIYLSIYLSNCAHNYLILFISIYLSIYLSIYLSIYLSIYLILYISIYLSLYISIYLSISVRSYLSIYLSRSVRIYLSIYLSIYLSIYLSIYLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EII2</accession>
    <name>A0A812EII2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_75123</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005451">
        <property type="protein sequence ID" value="CAE1325449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EII2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="280"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="309"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="385"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="415"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="451"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="475"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="505"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="534"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1325449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="585" mass="69216" checksum="F9649AF4F0AB27CF" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EJN8</accession>
    <name>A0A812EJN8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_72119</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005296">
        <property type="protein sequence ID" value="CAE1322103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EJN8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="134"/>
        </location>
    </feature>
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        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
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        <location>
            <begin position="183"/>
            <end position="205"/>
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    </feature>
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        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
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    </feature>
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        <location>
            <begin position="427"/>
            <end position="456"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="468"/>
            <end position="499"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="519"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="548"/>
            <end position="574"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="586"/>
            <end position="604"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="616"/>
            <end position="635"/>
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        <location>
            <begin position="688"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="719"/>
            <end position="740"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="777"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="805"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="837"/>
            <end position="862"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="924"/>
            <end position="945"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1322103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="962" mass="109367" checksum="1C19D0C09D6C39AF" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EK47</accession>
    <name>A0A812EK47_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_73881</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005398">
        <property type="protein sequence ID" value="CAE1324096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EK47"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="63"/>
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    </feature>
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        <location>
            <begin position="69"/>
            <end position="96"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
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        <location>
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            <end position="157"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="188"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1324096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="215" mass="25331" checksum="7F462118C500F137" modified="2021-09-29" version="1">MNTPTSIYLSIYLSIYLSIYLSMSVCSYRSIYLSVHIHLSIFYLSLSSIYLSIYLCQSVHIYLSIYVNLFISIYLSIYLSIYLSMSVCSYLSILLISIYLSIYLSIYLSIYLSIYVSLFISIYIIFIYLLNNATFYACIYLSMSFFIELTTYLCIYLSVFHVSTYLKMILFKSIYLSIYLSIYLSIYLSIYLSIYPSLFIIYLSIYLSIYLTLFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EKL9</accession>
    <name>A0A812EKL9_ACAPH</name>
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        <submittedName>
            <fullName evidence="4">RIX7</fullName>
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    </protein>
    <gene>
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    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthosepion pharaonis</name>
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            <taxon>Coleoidea</taxon>
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            <taxon>Sepiidae</taxon>
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            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Farmed</strain>
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    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005487">
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="entry name" value="Nuclear valosin-containing protein-like"/>
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    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="ATPase_AAA_core"/>
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        <property type="entry name" value="ATPase_AAA_CS"/>
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    <dbReference type="InterPro" id="IPR055278">
        <property type="entry name" value="CDC48c"/>
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        <property type="entry name" value="NLV2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031996">
        <property type="entry name" value="NVL2_nucleolin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48470">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 48 C ISOFORM 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48470:SF1">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 48 C ISOFORM 1"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Nucleolin_bd"/>
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    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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        <property type="entry name" value="AAA"/>
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    </dbReference>
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    </feature>
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        <location>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="958"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="982"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="3">
        <location>
            <begin position="641"/>
            <end position="781"/>
        </location>
    </feature>
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        <location>
            <begin position="447"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="507"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="482"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="546"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="558"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="580"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAE1326724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1018" mass="117837" checksum="11178B8DB2A3EE32" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EL92</accession>
    <name>A0A812EL92_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SPHA_75242</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005454">
        <property type="protein sequence ID" value="CAE1325582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EL92"/>
    <dbReference type="OrthoDB" id="3666223at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000032">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170:SF6">
        <property type="entry name" value="CONTACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170">
        <property type="entry name" value="PROTEIN SIDEKICK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="218"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="276"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="306"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="334"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="363"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="389"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="414"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="449"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="86"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAE1325582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="477" mass="56142" checksum="BCDFAD3F7C3EA756" modified="2021-09-29" version="1">MSRHMDVGSQLVWRCVVLAFPLAQFAWYKNSKLLRDGQDGIKIDGNTLKIESLVDSLHSGMYQCVATNNHGSSYSSAQLRVLSFKPIFAKNPVTAEQFACLGGSIMLFCQPEAAPFPTFNWTKDGYFITPKTNPRATILPNGNLVLKDVKAEDGGIYTCIAKNSQGEATSSGKVKVVRHSSISQKPRNTTVLVNETAFLYCHGSVPKSMDHIYNCHTFFLFSFFLTFPLFFIHFSILPFFFLSVSIFIVFSYILFSFFHILLFFVFHSFYFTHSFFLSFFLSFFHTFPFSFFLSFFLSFFLSYLPIFFLSFFLSFFLIFPFSFFLSFFLSFFPIFFLSFFRSFFLSYLPIFFFSFFLTFPFSLFLSFFFFLSFFLSFFLSFFLTFPFSFFLSFFFLSFFLSFFLSFLPSHFLSFFLSFFLSFFLSYLPIFFLSFFLSFFLSFFLSPSHFLSFFLSFFLSFFLSFRPIFFLSFFLSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ELA8</accession>
    <name>A0A812ELA8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_78065</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005528">
        <property type="protein sequence ID" value="CAE1328406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ELA8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="106"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1328406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="172" mass="19430" checksum="A7D7F018A46D2E53" modified="2021-09-29" version="1">MMAFYFSFKGGVKYYLANYLTILQMTTAFFLLLFLHHLLIPFLLLLFLLLPHPLLFLLRPFFFLLLFFPYLYIFNLIFFILFIFLPLLLLLFLSDFIFFSSSFPSSSSSPSSSSSSSSSSSSPPPPLTLSPLLLLYLPPPPPPPSSSSSSSSSSLISLFSNLHYPSLLSLFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EP84</accession>
    <name>A0A812EP84_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_74808</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005440">
        <property type="protein sequence ID" value="CAE1325188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EP84"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1325188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="265" mass="31243" checksum="B1F3B3FAA6544707" modified="2021-09-29" version="1">MLGCQRLQATTNKYLSIYLSIYLSIYLSICQSSEQSILIFISYYLYLSIYLSIYLSVVVCSHLSIYLCIYLSIYLFISTCHMFIYLSIYLSIYLSIYLSIYLILFIIYLSIYLSIYLSIYLSSCILISIYCFANIYLLLCYHLSIYLSIYLSIYLSQSVPIYLSIYLSIYLSVPIYLSIYLSIIPYLSFFIYLSIYLSIYLSIYLVHLSIYLLSIYLSKSVPIYLSIYLSLFISIYLSIYLSSRLRAGVDYYNYFYYYLLPITGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EQR7</accession>
    <name>A0A812EQR7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_77781</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005522">
        <property type="protein sequence ID" value="CAE1328203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EQR7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="304"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="390"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="417"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="443"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="470"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="525"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1328203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="546" mass="64036" checksum="0D37BF86EE2A041D" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ERD7</accession>
    <name>A0A812ERD7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="17">GRIN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">SPHA_79456</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Postsynaptic cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005568">
        <property type="protein sequence ID" value="CAE1330114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5984008at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000024">
        <property type="entry name" value="Glutamate receptor, ionotropic, delta 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015683">
        <property type="entry name" value="Ionotropic_Glu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18966">
        <property type="entry name" value="IONOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="7 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0770">Synapse</keyword>
    <keyword evidence="3 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="56"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="310"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="334"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="372"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="839"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="865"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="901"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1020"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1051"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1101"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1135"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1168"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1199"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1223"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1254"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1284"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1315"/>
            <end position="1339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1345"/>
            <end position="1369"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="15">
        <location>
            <begin position="711"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="16">
        <location>
            <begin position="721"/>
            <end position="783"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAE1330114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1370" mass="160277" checksum="A60EA78732CD4941" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EY61</accession>
    <name>A0A812EY61_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_81548</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005637">
        <property type="protein sequence ID" value="CAE1332508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EY61"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1332508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="174" mass="21036" checksum="FB1A39D2BDD64EA4" modified="2021-09-29" version="1">MRLYLIADTFMRSVQTTSCSVGLPGHFQKKNESFTVCLSVCLTVYLSIYLSIYVFLLGIFISPFRQHSIHRSHDISFRHSQIFSFFFSLSFSILYLFLFCFLFYFKFCFLFSLILFFFNSFFLSFFNSFFLSFFLSKVIFFLHYEFLKIDPFLFFMFIFFVLSLKFRFLSITFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AL25</accession>
    <name>A0A812AL25_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">B box-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SPHA_314</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000004">
        <property type="protein sequence ID" value="CAE1138983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AL25"/>
    <dbReference type="OrthoDB" id="6226111at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037688">
        <property type="entry name" value="ZBBX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28634">
        <property type="entry name" value="ZINC FINGER B-BOX DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28634:SF1">
        <property type="entry name" value="ZINC FINGER B-BOX DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22586">
        <property type="entry name" value="ANCHR-like_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="B box-type" evidence="3">
        <location>
            <begin position="129"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="342"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="412"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="283"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="351"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="366"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="412"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAE1138983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="444" mass="48976" checksum="F9B10793B80BA9B5" modified="2021-09-29" version="1">MNRYQSKMNFAAKTKARSFATMGAGFVDQIETRKMEERLQLMKKTMELEREERKNRGGQFWKSGQKGKLTTYANTVLQSRLSNKKVGKVKMLTDEQLNLPNRNEAFSLSKKLSDISNTSLDAFKTSTRNNAKLCGQCESNEAALCCIQCTEVYCTDCFSAYHKKGALRKHRSISLEVSSTPRSKVPNFDKRLFELNLTPLAADMKLQSDAKSSSGASGHLKTDEEEAAVSSLMDGNYNEAESAASFQEALQAWRTNNRSSGAAGAAADASIGFGTSGSHAAEISSSQPKPTNNEGVYTNSSTSTTAVTAGLASLMDNTQSHTLSYAERLLVKKNRRIPITWEQEPLNTTEPSERKDNSEQRKTLGTEESSSVLNSSKLPERLSVDEPVTFSSLYHLVAEDVTESVQLNTLKSQFSPTPKETMQNELTLKSEVSTTPAENFSEHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ALG6</accession>
    <name>A0A812ALG6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_1635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000046">
        <property type="protein sequence ID" value="CAE1145361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ALG6"/>
    <dbReference type="OrthoDB" id="5978656at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="311"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="343"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="380"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1145361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="417" mass="49379" checksum="E460C0C78116A9B9" modified="2021-09-29" version="1">MNVHYTTDTVSSSLKEVSSIGCVGERKGLRKEKKIFFFFFFVRTSEDSFKLQTQKKQRKQRKQHKRLTMGEYREAIEKTSFGLPMRENFLLDKETTFINHASYGSIPREVADAQNRLSHFLSLTLFLSVFLLLFSSHFLSPTHYLLSFHFFTFTHSLFLTFLFFTHTFFNSIFSLSLIHSLSSHFLILTFSHSHSFSLTFFFSFIFSHFLFPHTFSFSLFLILSHLLFLIHILSLSFSSHFLILSLFLIHSLSLFLVLSLFFSQIFSSFSIHSLFISSPQFFSFSFILSHLLFFLFLFLVFLTLSHSHTFLSYFFSFSFILSHLLFFLFLFLVFLTLSHSHTFLSYFFSFSFILSHLLFFLSFFFFLIHFLFSFPLFLTLIFSSTFFIILFFSLSHSLLFIPFSLMLLHSLHPSFYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812APJ6</accession>
    <name>A0A812APJ6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_2898</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000083">
        <property type="protein sequence ID" value="CAE1150126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812APJ6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="299"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="335"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="390"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="424"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="453"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="502"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="536"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="568"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="593"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="629"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="671"/>
            <end position="697"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1150126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="699" mass="82474" checksum="4DC38AE26E8B00CA" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AT81</accession>
    <name>A0A812AT81_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_4591</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000147">
        <property type="protein sequence ID" value="CAE1155909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AT81"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="308"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="337"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1155909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="364" mass="45337" checksum="1BBDAA69F1E0FD01" modified="2021-09-29" version="1">MLYDMNIYRNMYNLQSDQFFLRNKFDSNRSFFLYFLFLPIITFRSFFTYLFIHPDSQLLLLRFLLHLFLSMFFTSFLYMLFKLVFILAFFLFYFFKFYFIVFFLFSFIISFFFFPLFIPYFLFTFQFCSFLNIFNFFLSFFFLSTDFLFYFQFCTSLNLCNIFLSFFILSTDFLFYFQFCTSLNLCYIFLSFFILSTDFLFYFQFCTSLNLCNIFILFFIRSTDFLFYFQFCTSLNLCNIFILFFIRSTDFLFYFQFCTSLNLCNIFLSFFILSTDFLFYFQFCTSLNLFTFCPFFLFFFLSFFLSFFLSFILSFFFSFFLSFISIFIHHFLYIFSFLYSCYIILSSLFFLFFYFFFFFVILSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AU40</accession>
    <name>A0A812AU40_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_4637</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000149">
        <property type="protein sequence ID" value="CAE1156043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AU40"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1156043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="240" mass="28121" checksum="AD10FA5495790E20" modified="2021-09-29" version="1">MLFHYFYYSFHFPTLFESIYLSIYLSIYLSIYLDLKPPVLLHLTKYVSLFCPCPCLSLSLSLSLSLSLLLFSFVFYQITFHCVLSISVHFPTPNIGNKHLRASLRMFVKTQKYHSHLLHIYKICFLSLSMSLSIFLSPTLSLSLSLSFILTPISRRMHLLRLMQQLFSTGDFVFLSRHTSTFYYCSFILTNTFCNFPLSDSYVISLFLLFLSFPPLCSIYLSIYLSIYLSIYLSIWRSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AV84</accession>
    <name>A0A812AV84_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">COL6A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_7510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000241">
        <property type="protein sequence ID" value="CAE1163046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AV84"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1163046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="296" mass="35317" checksum="165CE4495B8E5628" modified="2021-09-29" version="1">MTFFFFLLLFIKLLPFFFCNVNLSSHLEGFFFFFFYILSFSLFSLFPSFIFLSFFFRDFLVVSVTCHVCLDAFLFVCFFPFPLFLCLFVCLFVCLFVCFFLSFFLSFFLVVFVTCHVCLDAFLFVSFFPFSLFLSLFVCFFLSFFSCSLRHLSSLSWCVFLSFFLFFLFSFFLFSLRSFMSVLMRFLFVSFFPFCLFVCFFLSFLVASATCQVCLDAFFFLSFFLSFFLSFFLLCLLLIAFLFLKSPSLDFFLSFFLSFFLSFSCYINFFLFFSIKLSFHFLFLSILLILLFLSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AVD0</accession>
    <name>A0A812AVD0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_5406</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000180">
        <property type="protein sequence ID" value="CAE1157814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AVD0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1157814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="302" mass="36564" checksum="8DDA5DF20A719DCB" modified="2021-09-29" version="1">MTRLYLLFSFFQNSYKNFPLNHSFFLSFFLSFFLSFFTYVQTLSLPPFLSFFLSFFFLSFFLSLRMFRLSLSLLFFLSFFLSFIVTTISFFLSFFLCVLRFHLFLSFFRFIFLSCSSSSPFFLSFFLSFPILSFFLCVLRFHLFLSFFRFLFLSCSSSSPFFLSFFLSFFLSFFLSFPILSFFLSFFLCVLRFHLFLSFFRFLFLSCSSSSPFFLSFFLSLFFLSFFPFFFLFIYLSIYLSIYLSIYLSINKKKKEDFIYLSFFFLSINNPVVSFRLFFSNRSFHIIASRSSRNKKISRRNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AZ54</accession>
    <name>A0A812AZ54_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">N-terminal methionine N(alpha)-acetyltransferase NatE</fullName>
            <ecNumber evidence="5">2.3.1.258</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SPHA_7902</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Farmed</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N-terminal L-methionyl-L-alanyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-alanyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50564"/>
            <dbReference type="Rhea" id="RHEA-COMP:12726"/>
            <dbReference type="Rhea" id="RHEA-COMP:12727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133398"/>
            <dbReference type="ChEBI" id="CHEBI:133399"/>
            <dbReference type="EC" id="2.3.1.258"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N-terminal L-methionyl-L-leucyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-leucyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50520"/>
            <dbReference type="Rhea" id="RHEA-COMP:12711"/>
            <dbReference type="Rhea" id="RHEA-COMP:12712"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133377"/>
            <dbReference type="ChEBI" id="CHEBI:133378"/>
            <dbReference type="EC" id="2.3.1.258"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N-terminal L-methionyl-L-lysyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50580"/>
            <dbReference type="Rhea" id="RHEA-COMP:12734"/>
            <dbReference type="Rhea" id="RHEA-COMP:12735"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133406"/>
            <dbReference type="ChEBI" id="CHEBI:133407"/>
            <dbReference type="EC" id="2.3.1.258"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N-terminal L-methionyl-L-phenylalanyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-phenylalanyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50528"/>
            <dbReference type="Rhea" id="RHEA-COMP:12715"/>
            <dbReference type="Rhea" id="RHEA-COMP:12716"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133382"/>
            <dbReference type="ChEBI" id="CHEBI:133383"/>
            <dbReference type="EC" id="2.3.1.258"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N-terminal L-methionyl-L-seryl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-seryl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50568"/>
            <dbReference type="Rhea" id="RHEA-COMP:12728"/>
            <dbReference type="Rhea" id="RHEA-COMP:12729"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133400"/>
            <dbReference type="ChEBI" id="CHEBI:133401"/>
            <dbReference type="EC" id="2.3.1.258"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N-terminal L-methionyl-L-threonyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-threonyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50576"/>
            <dbReference type="Rhea" id="RHEA-COMP:12732"/>
            <dbReference type="Rhea" id="RHEA-COMP:12733"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133404"/>
            <dbReference type="ChEBI" id="CHEBI:133405"/>
            <dbReference type="EC" id="2.3.1.258"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>N-terminal L-methionyl-L-tyrosyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-tyrosyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50532"/>
            <dbReference type="Rhea" id="RHEA-COMP:12717"/>
            <dbReference type="Rhea" id="RHEA-COMP:12718"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133384"/>
            <dbReference type="ChEBI" id="CHEBI:133385"/>
            <dbReference type="EC" id="2.3.1.258"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-terminal L-methionyl-L-valyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-valyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50572"/>
            <dbReference type="Rhea" id="RHEA-COMP:12730"/>
            <dbReference type="Rhea" id="RHEA-COMP:12731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133402"/>
            <dbReference type="ChEBI" id="CHEBI:133403"/>
            <dbReference type="EC" id="2.3.1.258"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.258" evidence="5"/>
    <dbReference type="EMBL" id="CAHIKZ030000256">
        <property type="protein sequence ID" value="CAE1164073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AZ54"/>
    <dbReference type="OrthoDB" id="47374at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031415">
        <property type="term" value="C:NatA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120518">
        <property type="term" value="F:protein N-terminal-methionine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000078">
        <property type="entry name" value="N-alpha-acetyltransferase 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051556">
        <property type="entry name" value="N-term/lysine_N-AcTrnsfr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42919">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42919:SF8">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 16" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="290"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="314"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="15">
        <location>
            <begin position="6"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAE1164073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="349" mass="39830" checksum="E76C792586D1186C" modified="2021-09-29" version="1">MTRGRIELGDITSHNIKQLKRLNQFVFPVTYNDKFYKDVLEVGELAKLAYFNDIVVGAVCCRVDNSVSQRRLYIMTLGCLYPYRRLGIGTVMLEHVLKICEEDGNFDNKDNVLILSIIHLSSIYPSIHLIHLSIHLSIHIIYISIHPSIHPSIYPHHPSIPSISIIPIHLSSYPSSIHPHPSPHPPIHPSIYPSIPIIHLIHPSISHPSIHLSILHLSYPHPSIPHPSIPSIHLYLSSHHLPIYPSIHLYLSISIHLSPSIYLIHLSSIHLISISIYISSSIYLSHLSILYPYLSIYLSISIYPSIYLHLSLSIYLYLSIYLYLSISIYLSLSIYLYLSISIYLSMLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B0A0</accession>
    <name>A0A812B0A0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_7614</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000245">
        <property type="protein sequence ID" value="CAE1163246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B0A0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032832462" evidence="1">
        <location>
            <begin position="36"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1163246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="155" mass="16709" checksum="0EC5C536DF159BD5" modified="2021-09-29" version="1">MLSLALFPPRHCSLLSLHPCSLLLSLLFILDLSDLSLHPCSLPVSLLSKSALSPSIFLLSFHRGSFLLSLLFILDLSHLSLHPCSLPVSLLSSCALSIVALSFYLCFSSLTSLTCLFILVLSLARCSLSVPPLLSHHLCSLHISLLSILDLSSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B173</accession>
    <name>A0A812B173_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_8994</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000289">
        <property type="protein sequence ID" value="CAE1166589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B173"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1166589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="161" mass="18857" checksum="5FD2F4FBEAA47372" modified="2021-09-29" version="1">MTRVVTALYLSIYLSIYLSIYLSISGSSIYLSIYLSIYLSIYLSISSIYLSIYLSIYLSISGSSISIYLSIYLSIYLSIYLSILVCSYLHSFFLSFFFNLTFFLIFLFVCFFFNFSPFFYFFLSFFLSFFLSFFLSICCLFSSSPPSFFLSFFLFNFTSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B337</accession>
    <name>A0A812B337_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_9988</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000320">
        <property type="protein sequence ID" value="CAE1168346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B337"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="375"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="427"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="462"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1168346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="498" mass="61116" checksum="CD92EAB18BF309BB" modified="2021-09-29" version="1">MFLILSFPFNSFFHFHFLLLFYYFLHSNFLDMFLTLPFRSDFRILQIILFFLSSRILILSFPSRPFLDTFPSTFPIISYLLFISFYSYYFLFFHSFYSSPFSLLSFFFSLFLILSFPSLPLISYSFPSTSPFHFLSLSFISYYLFFHSADSPYFLIFFLILLFLILYFFHLLFFQSIFPFFLTFHSSIFLILSFPSFPNRSYSFISFYSFRILSFNYYFLILSFRFYFSHYFLIFHFPSILHYFFLSFPFSLLVFLVFLFPSNFHHHFIFFPFFIFFHLKILHCSIFLFLFFSFSICTSFAIFFFFISFFFLFHFLEISSSFTSLFQLLFISLKFHHRSHPFYFYLNGFISFPISSSFTFFFLFHFLEISSRSHILFISFCFLEISSSFTSLFFSFFISLKFHHRSHIPFYFFFISFQFHHRSHISFISFFFSLNFIIVHDIPFISFFISVLKFHHRSHIPFISFFSFLFHHRSHILFFFSLKFHHRSHIPFISFLFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B341</accession>
    <name>A0A812B341_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_12058</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000402">
        <property type="protein sequence ID" value="CAE1172319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B341"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1172319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="181" mass="21023" checksum="93F63DAE07CCD62B" modified="2021-09-29" version="1">MDDNNAGYIYHVPRQGDYLFKKEQQTYPSDGLTPNFAAYTKRPDSLYIYNSISPFKLISSIYLSIYLSIYLCSYGAISHHFYLSIYLSIYLSIYLSIYLHIYYSDLTISVNFFVYLSLSLPLSHYSSIYLSIYLSIYLYAGLFVLYTYIYIVLTKSILLYKLISMYLSLSLSLSLSLSLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B4F2</accession>
    <name>A0A812B4F2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_9658</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000309">
        <property type="protein sequence ID" value="CAE1167839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B4F2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032840171" evidence="2">
        <location>
            <begin position="20"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1167839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="217" mass="25016" checksum="3C8FC4B522361954" modified="2021-09-29" version="1">MHSSLSFFTFFFFFSFSSAAVSCFFSSLFFFSSSCFIPLLSISSSSPLLHLFFYPFFFFNLPSFLPSFSSLFPLFLSFSSFLFIPNFHFTLFPSITSSPFTRPSSLPSLLSTPSLLFQTLFFLPPPALTHVYLLFLHSLITSHLFKIYLFFFLSSSLISFYLIIFFDFLFSYSSIFTPFLLNFSFSSFSPLPLFYFSATFFPNFTSSASNLVILFPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B597</accession>
    <name>A0A812B597_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ANGEL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_11143</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000366">
        <property type="protein sequence ID" value="CAE1170549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B597"/>
    <dbReference type="OrthoDB" id="10253982at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF34">
        <property type="entry name" value="PROTEIN ANGEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="93"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1170549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="197" mass="23462" checksum="C5FA0E8CC6FCED4A" modified="2021-09-29" version="1">MQPPEKRKHSSFIQEHLIVIDSSSSSEESSPCTSRKKYKKTLTRRWEWSDFGLKYRQKRSEYPGVEFSIMSYNLLAQDLLESHPHLYANSNWEVLLWEYRRARLLEEIDEHLPDIMCLQEVQCNHYDEFLKPKLEKRGYFGIYCKKSGNQSDGCATFFKVLKFELLNFRQFYRKSNKVAGGEKQAATITLKIWHYTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B5E3</accession>
    <name>A0A812B5E3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_10792</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000352">
        <property type="protein sequence ID" value="CAE1169851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B5E3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1169851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="268" mass="32657" checksum="03A1ABBEAE1941BD" modified="2021-09-29" version="1">MFVKIFLPSFFPSFFPSFFPSFRVDISFFLFSFFSFPPFSFFHSSYIYFLVFLLFVCIHFFNVQIHSLFFFYSTSLHISFSFIPLFILCFVFFLPFFPFFLPSFLPSFLPFFSFFLSFFLSFFLLSFLHFFIPSFFFFHSFFFFSFLLFFLLFSFLLSFLPSFPSFLHSFFLFSLILFFFFLSFLPSFFPSFFFPSFFLSFFPSFLHFFFLFFFLSFSFFLSLFVPSFHLSFFSPSFSLLLSFFFHSFLPSFLPSFLPSFFLSFFLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B670</accession>
    <name>A0A812B670_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_13623</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000458">
        <property type="protein sequence ID" value="CAE1175475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B670"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134:SF22">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134">
        <property type="entry name" value="OS08G0543275 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="302"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="386"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="423"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="452"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="487"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="519"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1175475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="542" mass="63212" checksum="62E48131125B112E" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B7T3</accession>
    <name>A0A812B7T3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_11371</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000376">
        <property type="protein sequence ID" value="CAE1171052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B7T3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1171052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="299" mass="33899" checksum="6E6B164C67228C62" modified="2021-09-29" version="1">MLFSALKRELLTMRGFSFSFLNPLYISLAISRSLSLTLSLYLTLYPSLLRSLNHYLVFTLPNSLSLFLSPSFILCLTLLLNNSLIVFSLFHPLSLKLFHSLSHFYSLSITMSFSLSLIHSQLFLSPSFILCLTLPLNNSLIVFSLFHPLSLKLLLSFTLYLLNCFTLSLSLSLLLSLSITMSFSLSLIHSHSFYRPFILCLTLPLNNSLIVFSLLLPLSLKLFHSLSLSLLLSLNHYVVFTLPNSLSLFLSPSFILYLTLPLNNFLIVFSLFHPLSLKLFHSLSLPFTLSQSLCRFHSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B8K4</accession>
    <name>A0A812B8K4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_15054</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000521">
        <property type="protein sequence ID" value="CAE1178217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B8K4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="298"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="325"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="350"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="380"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="405"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="429"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="458"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="482"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1178217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="508" mass="59516" checksum="8EA692FDE7DE090B" modified="2021-09-29" version="1">MSIDDDLPLATKTIYLSIYLSIYLSIVSIYLSIYLSIYVFLSESLSFFLYFYLSIYLSIYLSLFIIYLSISVYFIIYLSIYLSIYLLSIVSILCSLSFFSQFISLSSIYLSIYLSIYLSIVVYSQPSLFIIYLSLFYYLSIYLSSIHPSISIVVYHYLSIYLLSIYLSIYLSIYLSLFSTSPLSFLSISISLSLSLSIYTLSLSIYPYLSIYLYLSIHPNHLSIIHLPSIYLDNLFHLSIYLSIHLSIYLHLFLWLLKLSIYLSIYLSIYLSIFLSIYLYSIYLSISQSIYVSHYLPIYPSIYLSIYLSIHLFFLSISLPHLSSISIYFYLSIYLIFSSNLRISIHIYHLLSIIYLLSSIYTIFIYSIYLSIYLSIYTSFYLSSSIYLSIYLSFIYLYLSIYPSIYLSIYLLSIYLSIYLSIYSIYIQVFYLSIIYLVYLSIYLSIYLSQSFQYQSTYLSISLSIYLSIYLLSIYLSIYLSIYLSASIVYLSASTLLQGCWAILEFDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BAD3</accession>
    <name>A0A812BAD3_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SPHA_16137</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Farmed</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TMTC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="5"/>
    <dbReference type="EMBL" id="CAHIKZ030000563">
        <property type="protein sequence ID" value="CAE1226694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BAD3"/>
    <dbReference type="OrthoDB" id="19588at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013618">
        <property type="entry name" value="TMTC_DUF1736"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052943">
        <property type="entry name" value="TMTC_O-mannosyl-trnsfr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44809">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44809:SF1">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE TMTC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12895">
        <property type="entry name" value="ANAPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08409">
        <property type="entry name" value="TMTC_DUF1736"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13431">
        <property type="entry name" value="TPR_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="16" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 13" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="6 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
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            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
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            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
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            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
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            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="364"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1736" evidence="15">
        <location>
            <begin position="218"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="13">
        <location>
            <begin position="404"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="13">
        <location>
            <begin position="469"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="13">
        <location>
            <begin position="503"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="13">
        <location>
            <begin position="537"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAE1226694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="763" mass="87044" checksum="A331F4C45564C8BA" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BAN8</accession>
    <name>A0A812BAN8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_16295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000570">
        <property type="protein sequence ID" value="CAE1227151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BAN8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="310"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="375"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="409"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="439"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="466"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="508"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="545"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="574"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="599"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1227151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="631" mass="71988" checksum="E7D1C6554FF55E6D" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BFB2</accession>
    <name>A0A812BFB2_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GDP-fucose protein O-fucosyltransferase 1</fullName>
            <ecNumber evidence="4">2.4.1.221</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Peptide-O-fucosyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">SPHA_16442</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">Farmed</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-seryl-[protein] + GDP-beta-L-fucose = 3-O-(alpha-L-fucosyl)-L-seryl-[protein] + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:63644"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:17914"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57273"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:189632"/>
            <dbReference type="EC" id="2.4.1.221"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:63645"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-threonyl-[protein] + GDP-beta-L-fucose = 3-O-(alpha-L-fucosyl)-L-threonyl-[protein] + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:70491"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:17915"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57273"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:189631"/>
            <dbReference type="EC" id="2.4.1.221"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:70492"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 65 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.221" evidence="4"/>
    <dbReference type="EMBL" id="CAHIKZ030000578">
        <property type="protein sequence ID" value="CAE1227540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BFB2"/>
    <dbReference type="OrthoDB" id="10050276at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046922">
        <property type="term" value="F:peptide-O-fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11302">
        <property type="entry name" value="O-FucT-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019378">
        <property type="entry name" value="GDP-Fuc_O-FucTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039922">
        <property type="entry name" value="POFUT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21420">
        <property type="entry name" value="GDP-FUCOSE PROTEIN O-FUCOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21420:SF10">
        <property type="entry name" value="GDP-FUCOSE PROTEIN O-FUCOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10250">
        <property type="entry name" value="O-FucT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0294">Fucose metabolism</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 18" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0914">Notch signaling pathway</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17" id="KW-0732">Signal</keyword>
    <keyword evidence="7 18" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032313357" description="GDP-fucose protein O-fucosyltransferase 1" evidence="17">
        <location>
            <begin position="29"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00033080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CAE1227540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="383" mass="43731" checksum="7DD4EAF16BECDDC6" modified="2021-09-29" version="1">MMTRTTNSFDFLLLLVCFVLQITFSSSSLPIDANGYIVYCPCMGRFGNQAEQFLGSLSFAKALNRTFVIPPWVEYEPYVVGSLRVSFDTYFQVEPLKQFHRVITMEQFMDKLAPKIWPPSKRISFCYMSRASKGSNCNAKEGNPFGPFWDHFNVDFVGSEFHSPLSFDISSSGETKMWKQRYPSSKFPVLAFVGAPGPFPAHQNSLGLQQYIRWSDKIENEAKDFIQNKLQNLPFIGIHLRNGVDWKSACSHARSSPQMFASAQCTGYHNEHGRLTEEVCYPSDNTVIRQVKDTVKRLNIKAVFVATDDRDLIREMSKVMKKVKFVRAFPSNPHLDLAILSKADHYIGNCVSTFSAFAKRYRDTLGKSSSFWAFENNSRHLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BFI6</accession>
    <name>A0A812BFI6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_15755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000550">
        <property type="protein sequence ID" value="CAE1225513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="88"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
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    <sequence length="2815" mass="337317" checksum="2B57BD03AFD3B665" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BG14</accession>
    <name>A0A812BG14_ACAPH</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
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        <lineage>
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            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
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            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </evidence>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <location>
            <begin position="986"/>
            <end position="1007"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1234447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1011" mass="119904" checksum="E4F51EFEBD39E699" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BMG1</accession>
    <name>A0A812BMG1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="19">MEGF8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">SPHA_21559</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
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    <reference evidence="19" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000791">
        <property type="protein sequence ID" value="CAE1238897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000191">
        <property type="entry name" value="Multiple epidermal growth factor-like domains 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000202">
        <property type="entry name" value="Multiple epidermal growth factor-like domains 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056737">
        <property type="entry name" value="Beta-prop_ATRN-MKLN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
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        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056863">
        <property type="entry name" value="LMN_ATRN_NET-like_EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024731">
        <property type="entry name" value="NELL2-like_EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
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    <dbReference type="InterPro" id="IPR016201">
        <property type="entry name" value="PSI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093:SF16">
        <property type="entry name" value="MULTIPLE EGF-LIKE-DOMAINS 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24981">
        <property type="entry name" value="Beta-prop_ATRN-LZTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EGF_CA"/>
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        <property type="entry name" value="EGF_LMN_ATRN"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="EGF"/>
        <property type="match status" value="9"/>
    </dbReference>
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        <property type="entry name" value="EGF_CA"/>
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    </dbReference>
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        <property type="entry name" value="PSI"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="4"/>
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        <property type="entry name" value="Galactose oxidase, central domain"/>
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    </dbReference>
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        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Spermadhesin, CUB domain"/>
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    </dbReference>
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        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EGF_1"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
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    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
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    <dbReference type="PROSITE" id="PS01248">
        <property type="entry name" value="EGF_LAM_1"/>
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        <property type="entry name" value="EGF_LAM_2"/>
        <property type="match status" value="3"/>
    </dbReference>
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    <keyword evidence="3 13" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
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    <keyword evidence="12 14" id="KW-0424">Laminin EGF-like domain</keyword>
    <keyword evidence="9 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
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    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
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            <end position="577"/>
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        <source>
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        </source>
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    <sequence length="2538" mass="284346" checksum="38469EBDC4F36770" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BNF2</accession>
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                <person name="Bekaert M."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
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            <end position="1441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1453"/>
            <end position="1481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1516"/>
            <end position="1535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1542"/>
            <end position="1563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1569"/>
            <end position="1590"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1611"/>
            <end position="1636"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1642"/>
            <end position="1659"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1666"/>
            <end position="1684"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1696"/>
            <end position="1723"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1759"/>
            <end position="1782"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1855"/>
            <end position="1874"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1880"/>
            <end position="1901"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1908"/>
            <end position="1933"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1939"/>
            <end position="1957"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="2004"/>
            <end position="2023"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="2030"/>
            <end position="2051"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="2113"/>
            <end position="2135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1239054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="2148" mass="248518" checksum="7E1153A34EE5BB8F" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BRU7</accession>
    <name>A0A812BRU7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_21848</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000802">
        <property type="protein sequence ID" value="CAE1239321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BRU7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1239321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="224" mass="25630" checksum="E3514B84380D27C6" modified="2021-09-29" version="1">MEDAYPDDNNGCSRSSDVDLTRLNACSYLSIYLSIYLSIYLSIYLSKLNLIVCFFLSFAACSYLSIYLSIYLSIYLSIYLSIYLFEFYGGAEGCMWKSTAFSLSLSAAFWTNLCVSTSQPGISPSLSSAALNQGIYIRHFLLLLFKLYAPSYFFLSFYLSFFLSFFLSSPIFLLFSHSFFLSFFLSFLFFLSFFSISSSQFLIFSAFTLFLFLIDIFASINCLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BRW3</accession>
    <name>A0A812BRW3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_22454</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000831">
        <property type="protein sequence ID" value="CAE1240721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BRW3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="31"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="341"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1240721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="388" mass="46440" checksum="519E4DD26EA1FE84" modified="2021-09-29" version="1">MFLILCSDGDSELILSPSFSSSFWRLSSSSFLTISFFLTFFSFLFFSFLFFLSFFLFFSFLLFLSFFSFLFFSFLFFSSLLSFLFFSFFSFLSFFSFLFFSFLPYFLFFSFLFFSFLSFFLSFFLFFSFLSFFLSFFLSFFLLLFYLFSSFLFLLLLLLLLLLLAHIIVIIIIIIIIPSLYFPTFSFFLSFFLSFFFSFFLSLHHFPYTFLSSILFPLPSFFLRLIFIRVLLSPFCTLSFTFFLSFPFYFFSHSTFSSPLPKIMFLSLSISLFLSSYSFFFCIITITINIIIIIIIIIIIIIIIIVHIRFFILFLFAPLSFFLLLLFFHRRTLLVRQVISFSFFFLLFPFIQAFCISSIDALIFFHRNLHFCFINLGPPHFSKCLPLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BSV0</accession>
    <name>A0A812BSV0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_22314</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000824">
        <property type="protein sequence ID" value="CAE1240424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BSV0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1240424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="264" mass="30531" checksum="7A857F5B4AB67355" modified="2021-09-29" version="1">MNKNAFSPPPLSFSIYLSFFLSHILILTRILFFSFFFSGLSALFFLFIYLFCTHSLLYISFFLFVFFFSHFHSPFFSLLSFFAFSFALPLSRPSPFFDTCLPHPVSSLSYVFLLASRPPSCLPLITLLLYFFVSVHFYLSFPLSFFLSFFLSMCIFSLPFLCLCLSFSSPSLSLSLSLSLSLSLSLSVSYISTFFPFQINPFASSFFLTFTISSFFSSFFFSLNLSHIFFPFFFLFSSPFSRPHLSIFSLPLFPILHLKERTNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BU25</accession>
    <name>A0A812BU25_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_22966</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000847">
        <property type="protein sequence ID" value="CAE1241669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BU25"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1241669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="163" mass="18359" checksum="2F018660F5D4205A" modified="2021-09-29" version="1">MRNSGEIFTGMRERKDICSFFSLVNSPSLFLLQYHLSVSRHFSFNSHTISFSFLSQLFHFCLSVAISSSFLSFPILLSPSQISSFSSFCSFVSPYSSIYHIKINFLFSLSFSFSHINTFRPLFLFSSHSHLSSSFSAQSHTKSVVITISTTTSLVAVESQALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BVK1</accession>
    <name>A0A812BVK1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_27750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001087">
        <property type="protein sequence ID" value="CAE1251955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BVK1"/>
    <dbReference type="OrthoDB" id="6819399at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1251955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="232" mass="27249" checksum="AB23E63E7FCBC52B" modified="2021-09-29" version="1">MFFPLLFNSGFPLIRGFINIIFLTYFSNFLSFHFSCCLFFVYFLLTLLKLHAIFAAIFLSIYLSIYLSIYLSIYLSIYLSITRVSPIYLSIYNRCFTYLSIYLSIYLSIYCSFSLAIYLSILISMSLCSHLSFYLSIILSVSLCSHLSIYHPSFYVTVFTSIYLSIYLSIYLSIYLLIFLCYCVHIYLSIYLSNQLFIYLSNQLSIYLSMSVHKYNYLSNNLSIYLSIYLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BVT8</accession>
    <name>A0A812BVT8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_22685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000840">
        <property type="protein sequence ID" value="CAE1241130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BVT8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1241130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="289" mass="33576" checksum="5998DAD6C56FF387" modified="2021-09-29" version="1">MISLSVRWQWLENSYLLLSLSLSLSLSLIYYFFFFFLSFFLSLSLSLLLLHISLSSSSSSSSSSFDLQANTPITRTSDRWSGKITKQRRFLLLLFFLFLLLLLLFFFFFFFCSHFSSSSSSTSSSFSSSSSSFFFLLFFFFFFIFFFFSPFSSSSSSSFPLILLLPFLFFFFLLFFFSPSSSSAPILLLLFLLFPFFFFFLLLFFIFPSSSFFLFLLLPLLLYPSSSSFSSSFFFCSPSSSFPLLLLLLFPFFFFFLFLFFFFPPASSSSSFPPSSSSIYLSIYLSIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BZC4</accession>
    <name>A0A812BZC4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_24446</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000912">
        <property type="protein sequence ID" value="CAE1244758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BZC4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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            <begin position="39"/>
            <end position="62"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
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        </location>
    </feature>
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            <end position="184"/>
        </location>
    </feature>
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            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
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        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
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            <end position="286"/>
        </location>
    </feature>
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            <end position="317"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="329"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="373"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="428"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="469"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="508"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="541"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="583"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="614"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1244758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="649" mass="72854" checksum="5DB31AF8D33C2AE0" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C2X5</accession>
    <name>A0A812C2X5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_27378</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001057">
        <property type="protein sequence ID" value="CAE1251061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C2X5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1251061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="312" mass="37627" checksum="067DC57490E63972" modified="2021-09-29" version="1">MTNTVQFFFIYFFISSFFLSFFIHFSSFLITDTIPLPFIFSTILIFVRFFFRHLLLQIFYLFISYYLSFFFLSFFLSLLIRIFSFFPSFFLLSFFLSFFLLPFFLVTPSDPLIPCRVNPLLPALLTWCHIPPWLSLASSGNLLDRYYLILYLCICLPQTIIYLSIYLSIYLSIYLSIYRNLLISIYLSIYLSIYLSIYLSIYLSQPTHFYLSIYLSIYLSIYLSIYRNLFVSFFYLSIYLSIYLSIYRNLLISIYLSINLSQSIYLFYFYRNLHFIYLSIYLSIYLSIYLSISISIYIRFFFSIYLSILKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C3M2</accession>
    <name>A0A812C3M2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_28921</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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            <taxon>Lophotrochozoa</taxon>
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            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001143">
        <property type="protein sequence ID" value="CAE1254386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C3M2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="138"/>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="281"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="317"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="405"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="434"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1254386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="460" mass="53686" checksum="BE57C1C2B72F1726" modified="2021-09-29" version="1">MKIVQRGKKAGTDANRALHIHTYLCPYLSLSIYLSIYLSIYLSIYFSVFIIYLLVCLYLSIYLSIYLSIYLSIYLSIYLSLLSIYLSISLFIIYLYIYLCLFMSIYLSIYLSIYLSIYLSISACYLSIYLSIDLSQPVIYLSIYLSIYLSIYLSLYLSQPVIYLSMFFSLLYLSQSSVHIYLSIYLSITVSSLLIYQSFDLNFIIIYLSIYLSISVCSLSIYIFFILFISIYLSIYLSIYLSLLSIYLSIYLSIYLSISACYLSIYVLFLFLYLSQSSVHIYLSIYLSIYLSIYLSIQVSPLLIYQWFDLAQCHHYLSIYLSIYLSIYLSIYLISSVHIYLSIYISIYLSLFIIYIYIYLSLFISISLSISLSIYLSIYLSVYQSISSVHIYLSIYLSIYLSQSVHIYLSLSVCSYLSIYLSQYLSIYLSISSVHIYLSIYLSIYLSISVCSYLSIYLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C4J1</accession>
    <name>A0A812C4J1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_28181</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001111">
        <property type="protein sequence ID" value="CAE1252898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C4J1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1252898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="279" mass="31026" checksum="411D1926BD8F634C" modified="2021-09-29" version="1">MCVSRALSLPLSPSLSLSPPLSVSLSLSLSLSLSLSIYLSIYIYIYIIAGHSEESIAYAGSLIISLPLSIYLSLSLSLSSIYLSIYLPLSISLSFSCSLFSFSLSLSLFIYLSIYLSISISLSFSNSLFSLPLSLSLPIYLSIYISLALFFLFPSLTLYLSIYLSPSLYFSIFLLLSFSLSLSLFLSLSLSLPTYLSIYLSLFLFLLLSFSLFLTLTLSLYISLPFLSLYLLLTLLPSFLLSLSLSFSLSLFYGSFVLFLFTLETFRFRITTSHTAQFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C5G9</accession>
    <name>A0A812C5G9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_32843</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001369">
        <property type="protein sequence ID" value="CAE1261737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C5G9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032978145" evidence="2">
        <location>
            <begin position="22"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1261737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="167" mass="18522" checksum="C65589A73AAFFCE4" modified="2021-09-29" version="1">MIYSHVLDHLILLLHYLVCLSVEERCIPHSLILSHSLTLTLSHSFTLSLTLSLTLSFTLSLTLSLSLSVSLSHSLSLSLTLSLSIYLSTYTYIYKHFLQPHSLILSHSLSHSLSLSLSLSLSLSQSHSLTLSHSLSLSHSLSLSHSLSLSIYLSTYRFSFFIYLVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C5U6</accession>
    <name>A0A812C5U6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CENPJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SPHA_33136</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Farmed</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TCP10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001387">
        <property type="protein sequence ID" value="CAE1262291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C5U6"/>
    <dbReference type="OrthoDB" id="10252174at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061511">
        <property type="term" value="P:centriole elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.450.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009852">
        <property type="entry name" value="CENPJ_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047002">
        <property type="entry name" value="Tcp10_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026581">
        <property type="entry name" value="TCP10L/CENPJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058029">
        <property type="entry name" value="Tubulin-bd_CENPJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10331:SF6">
        <property type="entry name" value="SPINDLE ASSEMBLY ABNORMAL 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10331">
        <property type="entry name" value="T COMPLEX PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07202">
        <property type="entry name" value="Tcp10_C"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25779">
        <property type="entry name" value="Tubulin-bind_CPAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CENPJ tubulin-binding region" evidence="5">
        <location>
            <begin position="137"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Centromere protein J C-terminal" evidence="4">
        <location>
            <begin position="931"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="domain" description="Centromere protein J C-terminal" evidence="4">
        <location>
            <begin position="1005"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="domain" description="Centromere protein J C-terminal" evidence="4">
        <location>
            <begin position="1040"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="domain" description="Centromere protein J C-terminal" evidence="4">
        <location>
            <begin position="1077"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="79"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="186"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="312"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="489"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="572"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="816"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="650"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="22"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="99"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="336"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="489"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="538"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="587"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="599"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="828"/>
            <end position="840"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAE1262291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1121" mass="127088" checksum="1444D7C7F76D59B4" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C623</accession>
    <name>A0A812C623_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RDH13</fullName>
            <ecNumber evidence="4">1.1.1.300</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SPHA_30219</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Farmed</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.300" evidence="4"/>
    <dbReference type="EMBL" id="CAHIKZ030001213">
        <property type="protein sequence ID" value="CAE1256481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C623"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052650">
        <property type="term" value="F:all-trans-retinol dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAE1256481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="332" mass="37432" checksum="A022F9ED7F2E1042" modified="2021-09-29" version="1">MAGDFSSSFDSFFSSWYPIILALIGGFGFAFRQYLRGTPYESKKHLKGKTVLITGATCGMGKAAALAFAQRGARVVLACRDTELAEKVIKEIRDTCDNINVIALHCDLSSMESVRAFAKEFKKCESQLHILVNNAGVMMCPKDLTEDKFEMQFGVNYLGHFLLTHLLLDHLKKSAPSRIINVTAHAHQLGVIDFDDINQDNDYNPGHAYAQSKLAVALFTIELAKQLEGTDVTVNCVNPGVVNTSLHRHMPFRNHSFIKFCFAPFVWYLFKKPEDGINSMLFCALEDSIEQTTGKYFMECALTDWSEAVQNEEVRKKLWEESLKWTKVSFHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C972</accession>
    <name>A0A812C972_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_29230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001159">
        <property type="protein sequence ID" value="CAE1254873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C972"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1254873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="289" mass="35810" checksum="C66EDF34C7683DC4" modified="2021-09-29" version="1">MSFFLSFFLSFFLSFFLSFLRTLYFSFPFLINSFSYSFLLLLLLSFFLSFFQACLLNKCFFHSLIHSNFHSFLISFPYFYFITVFHSTSFLKSTSFCTSFFFFISFFQMIFFSCFLLHFHSWYPYFHFIHKSFISFIFRFFFISFFFFPRILFPLFFFFIVFFPRLLFPLFFSLFLSFLVFFSRSFFFISFFPSLLFPLFFFFLSSSSFPALFFFYFCIINLSFFYFFFFRSIIFNLLVSFIYFIFSLFFLYFSLFSFLFVVLSFFLSFFLSFFLSFFLSFLFVHPKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CEE6</accession>
    <name>A0A812CEE6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_32690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001365">
        <property type="protein sequence ID" value="CAE1261381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CEE6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134:SF22">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134">
        <property type="entry name" value="OS08G0543275 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1261381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="355" mass="41510" checksum="4F65BCA36710609F" modified="2021-09-29" version="1">MRSVIRKTLNRNLSSENYICAASYSKTEITNKDPPPPPKSLMQYLRLIYVDTTSLKFICIYLCLLVSIYLSIYLSIYLCFFKICWTSCIRHRSKPAENRSKTQIIYLSIYLSIYLSIYLSIYLSIYLCSYLSIYLSIYVCSYLSIYLSIYLSIYLSMSVHIYLSIYLCSYLSIYLFIYLCLFISIYLSIYLSMSVHIYLSMFISIYLSIYVHIYLSMSVHIYLSIYLCSYLSIYLSIYLSICLFLYIHQSVCFNLFMYICSYLSVCVCSYLSIYLSIYLSIYLNVMAPKELNFPGEISITTLSLTYSCPLLSRHSPTASPYSKRLFTAHTDTNKLAPCCQRPINKCNQWLNKNNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CGY9</accession>
    <name>A0A812CGY9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_34663</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001477">
        <property type="protein sequence ID" value="CAE1265423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CGY9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1265423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="200" mass="23183" checksum="DC3BDAD10CBBF3CA" modified="2021-09-29" version="1">MFNRCTIDGVIVATQRPSYKPNTTMLFSLSVASRCYSRILLFLEYLSIYLSIYLSIYLSQSVHILSVSVWKDLSFCYPSPLSLYLSIFYLSIFYIYLSLRISIYLSIYLSIYLSIYLSIYLSQSVQSVSVCSSIIYLYLSIYLSLHTHNTHIISISSINIYLSLSIYLSIYLSIYLSIYLSLFIYISLYLSQSVNIYLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CHN0</accession>
    <name>A0A812CHN0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_36232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001580">
        <property type="protein sequence ID" value="CAE1268708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CHN0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="321"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="348"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="376"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="404"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="429"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="456"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="486"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="515"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="541"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="573"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="603"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="700"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="743"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="777"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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</entry>
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</entry>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CMD6</accession>
    <name>A0A812CMD6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_36442</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001593">
        <property type="protein sequence ID" value="CAE1269184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CMD6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1269184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="180" mass="20097" checksum="F4A91FE1AD51A9AB" modified="2021-09-29" version="1">MYPLSLHVYLSISIYLSIYLSISHQMTFISLSLSLSLPSLIHLSQSVHVSLSIYLSIYLSSIYLSSLFLSLSLSLCPVYNISSVSSCLSIIYLSIYLSISLFSFFLSLSLSQSEYNVSSQSCLCLSIYLSIYLSIYLSISDIHSLSLSLSLSASLNSNVFPQSFHVYLSIYLSIYLSIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CNX2</accession>
    <name>A0A812CNX2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_42296</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002062">
        <property type="protein sequence ID" value="CAE1280391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CNX2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="351"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="386"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="415"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1280391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="436" mass="50877" checksum="5A356939B64052A4" modified="2021-09-29" version="1">MSFPVSLEYRNPHMAEPVIDKIKKCCFYLRTSSSSSSSSSSSSSSSSSSMWPPVSQSFFLSFFLSFFSTSVFLLFLSFTHPKYSFIPFFIPSFTSCQQIKHRRISILNFSSFLPSFLPSFLPSFIPSFLLFFHLFFLLSFFPSFLPSFFSSLFSSFFPSFLSFFLPSFLPSPFSFFLPSFLPSPFSFFLPSFLPAFFSSFLLFFLLFFLLFFLLFFLPSFFSSFFLFFHLSFFFSSFLPSFLPSFLPSFFFLSFFSSFLPSFHPSFLPSSFLPSFFSLMFSFLLSFHFFLLSLLLSFLPSFLFYFISSFSFFLPSLFSFLSSFSSFLLLSSLISFLLSFPPSLRLSLFLSFLFHFSSFRLSIPTLFSSFLPSFFSSSSLSIHVLSFYPIHFFCVKFLFPALLLLAIILNRIFFHLFNYLLFFNVYILFFSFINYTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CPE3</accession>
    <name>A0A812CPE3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_41122</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001968">
        <property type="protein sequence ID" value="CAE1278237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CPE3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1278237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="278" mass="33098" checksum="31852B86DE0D4B1D" modified="2021-09-29" version="1">MKIDWKTEAKCREGFAAKAKEERAEWFEEIFFSSFTGQFLLAVSFLRHLISFYFTSKHSTFSLDFAQFSFSFFPSFFCTFVFSFSLFYLYCSLSLFGSFCFLSLHLSFLLYLHLSFFPYIFHSFFIYIFRSFLTSFIPSLFTSFVLSLHLSFVLSFLISFFHFFLSFHLSSTFLFSFIFLPFFFFYIFTPFFFLSSFFHIFLSLHLSSIFFFPLIFLPLFLSFHLSSKFGFISSFHIFLSFRLSSIFSFILICLTIPTSVRLPLSIYLSIYLSIYLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CQ54</accession>
    <name>A0A812CQ54_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_41370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001981">
        <property type="protein sequence ID" value="CAE1278621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CQ54"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1278621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="165" mass="19555" checksum="ECD17DFC1B3FA62E" modified="2021-09-29" version="1">MMPTFLYSKTVRSPGRRGETCTISWPSNQLIPGNKAFVWYCFFLSYTIPMSLISFFYLMLKSNFWQVSKELEEYLSIYLSIYLSIYLSIYLSMDGSIAKAIKSFIYDEAKQQFIYRISSNPLSMTKQSLSFFYDEANQSFIYDKAIFFLRRTNQSYMYVKVMQIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CQA4</accession>
    <name>A0A812CQA4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_39817</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001868">
        <property type="protein sequence ID" value="CAE1275949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CQA4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1275949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="298" mass="34895" checksum="81EC1E80F9A743C0" modified="2021-09-29" version="1">MGIGSGIVTFTLTLIHLLIFFPRPLSSSSSSSSSSSFLLFFILSCFLFFIFFITDFFLSSSPSFLLLPSFSSPPSPHPPLLPHLYCSLSSLLSFLYLPHSQFPFLVLFLFLLFLHFFFFLSTLPYPLFLFFFFTFFITNFLSYSFFTVFISISCHNFLFFLCLFFSFSFFFHFSSCYSSLSCISSSLFLLTILFLLPFTSFSDQVFFFSFLYIFFFSLLFFAFKYLSTIHSLTHINHFLRYSRLFISIYLPIYLYIYLSIYLTCSYLSIYLSIYLSIYLSIYLSQSVHLLIISSITPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CRN2</accession>
    <name>A0A812CRN2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_39419</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001828">
        <property type="protein sequence ID" value="CAE1275354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CRN2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="308"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="344"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="380"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="438"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="490"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="522"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="551"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="574"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="602"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="640"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="681"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="763"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="790"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="817"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="852"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="900"/>
            <end position="922"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1275354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="922" mass="106195" checksum="2CAEA06974DEF796" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CW00</accession>
    <name>A0A812CW00_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_41572</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002001">
        <property type="protein sequence ID" value="CAE1279015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CW00"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="51"/>
            <end position="67"/>
        </location>
    </feature>
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        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
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        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
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        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1279015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="293" mass="33553" checksum="C9E814CC54045677" modified="2021-09-29" version="1">MCSFIAFSLSSSSSSSSSSSSSSLSLSLSLSLHLIHAHYDIADNQSKNAHLLFLIISFTHLIPPFSLSSSLSFSLSLSLSLSLSLSLTHAHIHTSPVPHSFLSLFYAFTHTIAQLLILFHSLSFKINIYKTYLSFKRSYIRKTPKKHLFSIIYWNFSLSLFLFHSLFLSDLPSFSLRLFYSLFHSTSLSFFLSSFYPFFLSFVFFFFDYTTFQFLSLFFHNLCRSLSLSLSLSLSWSLCVSLFQISDLFLFFCFSFFSVFLFQIHSLFPFLSSPFSLPLSLFPFLSAFLSLYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D481</accession>
    <name>A0A812D481_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_44997</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002315">
        <property type="protein sequence ID" value="CAE1284856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D481"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
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        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
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        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
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            <end position="91"/>
        </location>
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            <end position="120"/>
        </location>
    </feature>
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            <begin position="132"/>
            <end position="153"/>
        </location>
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            <end position="182"/>
        </location>
    </feature>
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        <location>
            <begin position="264"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="313"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1284856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="373" mass="43929" checksum="2625DEDAA203804B" modified="2021-09-29" version="1">MSVSISIYLSIYLSIFVISSYLSIYLSIYLSKSILISIDLKLYLYMLVSSFFPLLLFLSIYLSIYLSIYLSISSLHIYLSIYLSIYLSIYLSQSVHILSIYISVCSLFINVSLFTPYLSLSLSHYPSLSLSIYIYIYMRFNFFIACLSIYLSIYLSQYVYIHRDFFTIYLSIYLSIYLSIYLSPSRYPLSISSLSIYLSIYLSICRDLLIIYLSIYLSIYLSIYLSQLLSIGKSFRREIIFILSISIYLSHLCLSNYLSISFSFYIYLSIYLILFISIYLSQRSRQYFLLNNLSIYLSIYLSIYLSISVRSYSIYLSLFISIYLSIYLYLSIYLSQSVHYPSIEQQYLSIYLSIYLSIFLSIYLFQINPSIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D5R3</accession>
    <name>A0A812D5R3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SEC23-interacting protein,Phospholipase DDHD2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SPHA_46607</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Farmed</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PA-PLA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002475">
        <property type="protein sequence ID" value="CAE1287475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D5R3"/>
    <dbReference type="OrthoDB" id="69269at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22249">
        <property type="entry name" value="UDM1_RNF168_RNF169-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004177">
        <property type="entry name" value="DDHD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058055">
        <property type="entry name" value="PA-PLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004170">
        <property type="entry name" value="WWE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057825">
        <property type="entry name" value="WWE_SEC23-DDH2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23509:SF10">
        <property type="entry name" value="LD21067P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23509">
        <property type="entry name" value="PA-PL1 PHOSPHOLIPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02862">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02825">
        <property type="entry name" value="WWE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23464">
        <property type="entry name" value="WWE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01127">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </evidence>
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    </evidence>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D883</accession>
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        <recommendedName>
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            <strain evidence="7">Farmed</strain>
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        <subcellularLocation>
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    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </dbReference>
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</entry>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003043">
        <property type="protein sequence ID" value="CAE1295487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DCN4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="280"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="304"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1295487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="335" mass="40247" checksum="70599AA8F237AA02" modified="2021-09-29" version="1">MLTSFFFLSFFLFFLSFFLSFSFLFYYLSCFNIFHYSHFFLFSVLPSSSSHTVHLFICSYFPSSFVLSFFLSFFLSFFLSFFLSFFLLSFFLLIYVLISYITISFCFFFFFFFFFFFSTSICSQIVHYLHIFSFLSFFPSFFLSFNIGLVSYILIFFFFFFFFFFHPLSALTLFTIFIYFFLSFFLSFFLCISFLFVFAFLIYICSYTFQYIDDDDDAHHHLHNHHRHHHHHNLLLIIIITIIIIIILYAHILGMFYFLYRSSSSSHYFSYLSPSLLPNLSFPSFLPLFFLLTISYLRPQLFLLLLFLLDFILSLSLSLSLSLSLSLSIGPFVNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DDJ1</accession>
    <name>A0A812DDJ1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_50846</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003024">
        <property type="protein sequence ID" value="CAE1295311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DDJ1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="279"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="303"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="341"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="370"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="399"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="430"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="459"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="490"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="523"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="551"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="584"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="611"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="646"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="674"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="711"/>
            <end position="736"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1295311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="754" mass="86448" checksum="41B9FBA77A98261F" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DDS7</accession>
    <name>A0A812DDS7_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SPHA_50982</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Farmed</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003047">
        <property type="protein sequence ID" value="CAE1295567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DDS7"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008395">
        <property type="term" value="F:steroid hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11055">
        <property type="entry name" value="CYP3A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000182">
        <property type="entry name" value="Cytochrome P450 3A4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050705">
        <property type="entry name" value="Cytochrome_P450_3A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24302">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24302:SF15">
        <property type="entry name" value="FATTY-ACID PEROXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9 10" id="KW-0349">Heme</keyword>
    <keyword evidence="6 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="4 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="638"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAE1295567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="692" mass="80715" checksum="3D1366CB13D90A96" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DGM6</accession>
    <name>A0A812DGM6_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DEP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_52530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003282">
        <property type="protein sequence ID" value="CAE1298375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DGM6"/>
    <dbReference type="OrthoDB" id="524326at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16206">
        <property type="entry name" value="DEP DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16206:SF4">
        <property type="entry name" value="PROTEIN LET-99"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1298375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="319" mass="36291" checksum="5CD3CF049A45FF84" modified="2021-09-29" version="1">MTTANGHQSSSNCSKKSYSRVLFDQENVSSELCHQQRSLSRLSGSKQKCESTGSIPLLSCSWQPARSLLYGRHSTSSIPNLSPVETLDKHGRKRYSTISGAWPMPDDERVKQAVRLVLLLLPPANRRKLHLLLRFLNKVKANTELQLADNPDALQTLLIDTFYQAIICSPDSSDMDINLAKHLVLYLIENHDIVMQVPSDLRSQVEDRLSQLQRVQVVYTSDDKGATTYCKQVPVAVYEKEAIRHSTDALGDLLKSIVADEKMNQKEKTKKLREFQRLYPQIYEKEFGSESGPIQPSQRKPSRNVHLPRPLRRLRTLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DHC5</accession>
    <name>A0A812DHC5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_52280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003229">
        <property type="protein sequence ID" value="CAE1297852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DHC5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1297852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="258" mass="31212" checksum="55A5FBC963735623" modified="2021-09-29" version="1">MLIRYEYRSIQLIDSRLLRPYLLAGFLSFFLSFFLSFVLSFVLSFFNIRVFFLFSFFLSFFLSFFLSPPFHIYLSIYLSIYLSIYLSIYLNSLCAYLSIYLSIYLSIYLSIYHSLFIYRYPSLFSFFLSFFLSFLSFFLLFHFFFFVISIYLSIYLSISVDIYLSISAFFDIYLSIYLSNFIHIYMYAYVYIYICIYTYIYIFVDIYLSIYLSIYLSQSLLISIYLSIYLSISVSYLCIYVSIYLNLFLYIKSIYLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DHX0</accession>
    <name>A0A812DHX0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_56746</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003791">
        <property type="protein sequence ID" value="CAE1304063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DHX0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="3"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1304063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="264" mass="30501" checksum="BB93B2F63A30903E" modified="2021-09-29" version="1">MASSSLRKEILEAKKHLVDLQEDVEEFEKRLRRGIELTKKSIEQLSINCEENCCKVWQEFDEFLKKIRMKAAELCNQMREKTSEEERKWCQFLKEKENLLEEAGKWLLDLRHLFAASIDDEDVVSGVQSLRAELSGRLHVEEGHFVVTFPEWCQQSLTQLQEEIVDFKTAKTIELELESEFRLQDSNLGLIHSIAVSDEDGHVFVVDGCDYSIKEFDETGEIVARCPLMDEGFFPFNICCLSHDNFVVSGVGVRVVDGELWFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DJA0</accession>
    <name>A0A812DJA0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_57463</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003877">
        <property type="protein sequence ID" value="CAE1304927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DJA0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="298"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1304927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="333" mass="40491" checksum="EBBE90DBB402112D" modified="2021-09-29" version="1">MLAFIFYSELSPFASNCLSCLPPSKSDRTFSFPFFLSFFLSFFLSFFCNFYFYFIIFIFFFISSFFFSFLSSFCTFSTASAIFLFPYLFRFFLAVFFPSFSHVCFPLFFLDFCYFFFLFSFFFFFFFILFLSFFLSFLFSSPFLLCFFLFVLSPKKKSILFFIFLPSYSSGFSLSPLLNSLSFLFSTLPSYSSSFSFSLLMTSLLLLRLTYILPSFLLMLLLFYNFILFHYLILYLLFTFIFFYSFASIFLLLFVFFLFFLIYFLPFYPRSFILFLSFLHFVFYILICFSFFFVFLLFIYFFSILILFIEFSFVSLFGLHFRFHFHFFFFTTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DKJ7</accession>
    <name>A0A812DKJ7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_55302</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003667">
        <property type="protein sequence ID" value="CAE1302961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DKJ7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039715">
        <property type="entry name" value="ZCCHC10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13491">
        <property type="entry name" value="ZCCHC10 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13491:SF0">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="347"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="384"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="414"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="443"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="472"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="513"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="647"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="685"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="712"/>
            <end position="739"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1302961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="778" mass="88175" checksum="F5660488A76DC970" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DLG5</accession>
    <name>A0A812DLG5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_56544</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="CAE1303769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DLG5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="6"/>
            <end position="28"/>
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        <location>
            <begin position="40"/>
            <end position="66"/>
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        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1303769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="174" mass="20940" checksum="25C4A96191EABAC2" modified="2021-09-29" version="1">MIHIPLEISLSLSLSLSLSIYLSIYLSADDKKSEDIYTSNIILLYSFFLFSDCFFTFFLHLSLFFLIFLRNFFHFSVIYVLFPFSVFSSFIFSSRRLSVHDNISFIHVDDFHFSDFYFFFIRFYFFISIFIVYLFIFLFTSFPILFIHIFFLFILPLFTVTVSEQNTSYFSDIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DMD9</accession>
    <name>A0A812DMD9_ACAPH</name>
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        <recommendedName>
            <fullName evidence="2">Heme-copper oxidase subunit III family profile domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="3" type="ORF">SPHA_59261</name>
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    <organism evidence="3 4">
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        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
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            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
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            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
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                <person name="Li R."/>
                <person name="Bekaert M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
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    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="term" value="F:cytochrome-c oxidase activity"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="InterPro" id="IPR000298">
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    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="COX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="308"/>
        </location>
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    </evidence>
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    </evidence>
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            <dbReference type="Proteomes" id="UP000597762"/>
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    </evidence>
    <sequence length="1129" mass="137215" checksum="6CFC200C53214580" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DNH7</accession>
    <name>A0A812DNH7_ACAPH</name>
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        <submittedName>
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        </submittedName>
    </protein>
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    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
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                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </evidence>
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</entry>
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        </source>
    </evidence>
    <sequence length="612" mass="73526" checksum="7A6C2A08F6D9F3CB" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DQX0</accession>
    <name>A0A812DQX0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_58629</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004020">
        <property type="protein sequence ID" value="CAE1306350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DQX0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="284"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="322"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="350"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1306350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="389" mass="46299" checksum="320F0BE2909628F3" modified="2021-09-29" version="1">MAERNRPIETAKYCHDIIRNILSVIFFLLLNLNLLIYVIRLLSIYLSIYLSIYLSIYLSQSVDYLSFFQPVGFSFVCFSLRMVPFLFYFFLLGYFLSFSSLPFFHCIHLYFLSFLFLLLYFKFIHILSFFLSFFLSFVFLSLHYGFCLGIIFFFVITFSSSLFNLNFLSFCLFLLNFEEMCSHSFFLSSFSLSSLISFICSFLSSFSSSLFNLNFLSFFYFFFLFFSFFISLFVSLFLSFLLSSLISFIRSFLFFSSVFIFKFSFVFLFLIFRRNVFTFFFQIFSNVFTFFLSFFLSFFLSFFLSFFLSFPPSSLISLIRSFFSSFSSSLFNLNFLSFFVYFCLISKKCVHILFFLFSFFLSFFLSFPPSSLISLIRSFFSSFSSSLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DSJ9</accession>
    <name>A0A812DSJ9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_59586</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004123">
        <property type="protein sequence ID" value="CAE1307553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DSJ9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1307553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="275" mass="33360" checksum="ED26CF97FA376A02" modified="2021-09-29" version="1">MYPGTRLGNGRAKEERKLNGGGVDQDFRWEVLCLSFFFPFYLFLYFYLPLFNSICLFLSVSFLLCFFILLLSLFFLSASFFLSFFFPFFLSFSFRFILFCFFFLLLSFFFLSASFFLCFSFCFFLSFFFPFFLSFFFFLLHSFLFFLSASFFVFLSPSFFLCFFLSFFLFFFLSFFFFLLHSFLFFFLLLSFFFLSASFFFVFSFCFFLSYFLLVFISTWFFLSLHLSIYLDLALSFFLSFFLSFFLSFFLLVSIYFDLSLSFFLLFVIPYLVIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DUS7</accession>
    <name>A0A812DUS7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SPR</fullName>
            <ecNumber evidence="4">1.1.1.153</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SPHA_59465</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.153" evidence="4"/>
    <dbReference type="EMBL" id="CAHIKZ030004120">
        <property type="protein sequence ID" value="CAE1307427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DUS7"/>
    <dbReference type="OrthoDB" id="153074at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004757">
        <property type="term" value="F:sepiapterin reductase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051721">
        <property type="entry name" value="Biopterin_syn/organic_redct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44085">
        <property type="entry name" value="SEPIAPTERIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44085:SF2">
        <property type="entry name" value="SEPIAPTERIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="3">
        <location>
            <begin position="38"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAE1307427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="375" mass="41973" checksum="D95BB5DB8D62610B" modified="2021-09-29" version="1">MCGFIFVCQLVLPGGVYNKKDTEVSENVVRSCDRCQSIDPSPNIHELGEIQVDTNWTRLSIDGTHYRGEMYLTIVDCGPGRFAIWREIRAATADIIAKELEEIFFERGPVEVLMDNGAAFRSEVFRSMLDKWNTRQYYRAAYRPSGNAIQHFKYLSLYCTGKAARDMFFKVLAAEEPTIRVLNYAPGPLDTDMQTCLRENLGDAENRAMIKEMADQGKLVKCEDTVQKLIHILCKNTFTSGLTSQSHSITTLRDSTHFTLRYCLPSVTPALLQHPALLQLPARSCSLQLIPAPSSTPAASSSFLHLPALLQPSAHSYSFQLTPAVYSSPLRRFTDVPRPIPAPADDLIQCPLTSSARYRPDTVQTTSVFFTTVCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DV12</accession>
    <name>A0A812DV12_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AP5B1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_61926</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004391">
        <property type="protein sequence ID" value="CAE1310351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DV12"/>
    <dbReference type="OrthoDB" id="646197at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030119">
        <property type="term" value="C:AP-type membrane coat adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038741">
        <property type="entry name" value="AP5B1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048981">
        <property type="entry name" value="AP5B1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048979">
        <property type="entry name" value="AP5B1_middle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34033">
        <property type="entry name" value="AP-5 COMPLEX SUBUNIT BETA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34033:SF1">
        <property type="entry name" value="AP-5 COMPLEX SUBUNIT BETA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21590">
        <property type="entry name" value="AP5B1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21588">
        <property type="entry name" value="AP5B1_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP5B1 middle" evidence="1">
        <location>
            <begin position="224"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="domain" description="AP5B1 C-terminal" evidence="2">
        <location>
            <begin position="798"/>
            <end position="894"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1310351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="899" mass="101757" checksum="F7F549BB7730C43E" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DVC4</accession>
    <name>A0A812DVC4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_61498</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004360">
        <property type="protein sequence ID" value="CAE1309850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DVC4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1309850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="314" mass="38006" checksum="58F7EBAEE9AC9B05" modified="2021-09-29" version="1">MRCKEALSNLSRFEDILNWVSTGLKFSLGAYTQIMQHYSFFLVPFLHFLFLSFFLSFFLSLLFLHIIHFPSLFFLLLSCFFLKLFFQFLALTHLSFFSFFLSFFSFFLSFFLFLFFLISFPTSAFLSLLLFFISHILFYNGFRLLSLFSFFFFFFLSFFLSFFLSYFRSFLSFFLSFFLSFFLSFPIFSYFFSHVCFLSFFVIFPISYYFFFLVCFLSFLSFFSFFLSFFLSFFLSFFLYSISLFSPYISNLFLECPCIIFLSFFGLSFILLFLFSFFLSISISFHIEFLFLFLNICLILSSFYASIYFYYLSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DYS0</accession>
    <name>A0A812DYS0_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ShKT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SPHA_63037</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004519">
        <property type="protein sequence ID" value="CAE1311688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DYS0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007951">
        <property type="entry name" value="KRTAP_PMG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05287">
        <property type="entry name" value="PMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="172"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="217"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="250"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAE1311688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="314" mass="35583" checksum="DC1F4AB46F9ED742" modified="2021-09-29" version="1">MRCRLVVFKYKYEACPKSCDNHFCIPQSCDNHFCTPQSCDIHFCIPQSCDNHFCIPQSCDIHFCIPQCCDIHFCIPQCCDIHFCIPQSCDCDINFASILTSIVASLKVVTSIFASLNVVTSIVASLKCVTSIFAPLKVVTSIFAPLKVVTTIFTPLKFVTSILAPLKVVTSIFASLKFVTSIFASVKVVTSIFAPLKVTKRQAEIKRRYAEIYLSRVSSYLSIYLSIYLSIYLVCLFISIYLSIYLSLFISIYLSIYLSIYLSIYLSPLHLFISIYLSISCISSSIYHLSIYLSIYLSIYLSIVYLHMKFIENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E3T3</accession>
    <name>A0A812E3T3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_67581</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004896">
        <property type="protein sequence ID" value="CAE1316902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E3T3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="296"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="363"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="390"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="427"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="462"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="488"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="516"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="595"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="626"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="661"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1316902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="693" mass="79594" checksum="AA860C76DA257458" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E5Q3</accession>
    <name>A0A812E5Q3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_68556</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004991">
        <property type="protein sequence ID" value="CAE1318062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032380094" evidence="2">
        <location>
            <begin position="22"/>
            <end position="1294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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    </feature>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1204"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1228"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1269"/>
            <end position="1289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1318062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1294" mass="151306" checksum="80391C31F62344DA" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E5Z1</accession>
    <name>A0A812E5Z1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_66298</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004782">
        <property type="protein sequence ID" value="CAE1315387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E5Z1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1315387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="191" mass="23192" checksum="249371FC22663EBA" modified="2021-09-29" version="1">MDDALAILVIEAVMVSCFTIFAGFFFLSLLFALSFFLLFFSFTCPFFFFLYSLFFIHYYLLYSFCISSYLSLSISSFHQCFFLSIIFLKYFLFPPFFLSFPSFIHSFCFFIILCFLSFFSLRSPFFLYFFFYMFFVLSIYYCFQHILIVSFLLLYNFLFFLYSLHFFFLLFLLSFFIPPPPISLYFPSYFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E811</accession>
    <name>A0A812E811_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_67354</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004879">
        <property type="protein sequence ID" value="CAE1316680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E811"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="325"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1316680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="355" mass="41864" checksum="625D5D354E376A0E" modified="2021-09-29" version="1">MPNIYLYFTEYFHSLFLSIFTFFFFFLSFCSFKHSYFLLAITYFLSVRYSLSFFYNFSFLSVIVSLSIVFLSFFLSFFLSFFLSLFIYFLEIANSYSSSFYSFLFLFFPFFPSFTFQNCCFASPSLSFPTSFPPSSFAAGSSTNIVFRRNTDLLSDCSCLLETVLSNLSCHLSIYLSIYLSIYLSIYLSILIIAQHVIIFMVIYLFIIYLSIYLSIYLSILIRAQHMLEYLWLSIYLSIYLSIYLSIYLSIYSDKRTTHIRIFMAIYLSIYLSIYLSIYLSIYSDKSTAHVRIVMAIYLSIYLSIYLSIYLSIYSDKSTAHVRIVWHYLSIYLSIYHLSIYLSISLSLSLSLYLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E813</accession>
    <name>A0A812E813_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_68159</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004949">
        <property type="protein sequence ID" value="CAE1317620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E813"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032602383" evidence="2">
        <location>
            <begin position="18"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="302"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1317620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="377" mass="43190" checksum="F9F0A263C701F8C2" modified="2021-09-29" version="1">MSIAILFFYCSLSLSLSLSLSLSLSLSLIVCYCYLLSLNLSTTKRNRAVNMFGSDKLVAPNFGGKGITVNYLSIYLSIYLSIYLSIYVSLLFNIFIYPNLFFFFYLSVCFNLSIYLSIYLSIYLSIYRSLFISIYLSIYLSIYLSIYLSIYLITDHPSKPAGSESSSRTLFFSFVYVYVCVFMCASIYLSIYLSIYLSIYLSIYLSIYLCQSSISSLFIYLSIYLSIYLSQSVNIYLSIYLSIYLSIYLSIYLITDPPSKPACSESSSRTLLFLALSAWLSIYLSIYLSIYLSIYLSVLKSVYLSIYLSIYLSIYLSIYHDSTCPLADQRIVVHSQRTYSVSIFSYSLFPSNPPTQLCSCLNVRLNGWQTTEEEFDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E9U4</accession>
    <name>A0A812E9U4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_67284</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004872">
        <property type="protein sequence ID" value="CAE1316618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E9U4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF5">
        <property type="entry name" value="DYNEIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1316618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="486" mass="56330" checksum="9CCFF123C407AB43" modified="2021-09-29" version="1">MIEEKQFSLVRTLSLSLYLSVSLSPSLSQYLSPSLSVSVSPSFSHYLPPLSLPLPASIHYSTHSSIHYSTYSPNHYSPHSSNHYSTHSSNHYSTHSSNHYSTYSSIHYFTYSSIHYTEYSFINYSTHSSNHYSTHSSIHCSTYSPNHYSTHSSIHYSTYSPNHYPTHSSIHYSTYSPNHYSPHSSNHYSTHPSDHYSTHSSNHYSTYSSIHYFTYSSIHNSEYSFINYSTHSSNHYSTHSSIHYSTYSPNHYSTHSSIHYSKYSSIHYFTYSSIHYSEYSFINYSTHSSLHYSTHSSINYSTHSSINYSSYFSIHYSTHSSIHYSTHSSIHYSSYSSIHYSTHSSIHYFSYSSIHYSTYSSINYSTHSSIHYSTHFSINYSTHSSIHYSTHFSIHYSTHSSIHYSTHSSIHYSSYNSIHYSTYSPNHYSTHSSIHYSTYSPNHYTTHSSFHYSTYSPNHYSTHSSIHYSTYSSIHYSLHIQIAVCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EE78</accession>
    <name>A0A812EE78_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_71942</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005273">
        <property type="protein sequence ID" value="CAE1321922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EE78"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1321922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="285" mass="34397" checksum="635F705B1BEF841A" modified="2021-09-29" version="1">MDCIFLSVFLSFFLSFFLSFFLNLILHFLFSFFLNTIFRFLLSQHHFTFSFLLSFFLSFFLSFFLSFFFLSFFLSFSLLFLPRFFLSFFLSFFLSFFLSFFLNRIKSAVNKKKLFRQPSYLSIYLSISIYLSIYQVCLFIIYLSIYLSIYLSIYLFIYLSIYLLVIHLFYLSIYLSFHLSIYSSIYLSIYLFIYLFYPVFSLSILSIYLSIYLLSIYYLYLSIYLLVFSLSLSIYLSIYLSGHFSIYLSSIYLSIYLLYLFIYLSISLFSLSIYLSIYLSIYLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EEG0</accession>
    <name>A0A812EEG0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DCLK1_2</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_71608</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CAHIKZ030005241">
        <property type="protein sequence ID" value="CAE1321469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EEG0"/>
    <dbReference type="OrthoDB" id="1738954at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="210"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="254"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="285"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="324"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="387"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="411"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="445"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1321469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="463" mass="54811" checksum="CF9293480FCC1643" modified="2021-09-29" version="1">MVLKKLNINDSSSTYCRSKHSSPNSSRTASPRPRRKLTSESDKSPVNGASEECAANYPYALISKYGVRRLIGEGNFAVVKECWARSTNTRYALKIIDKTKCLGNRQNSLRTCHFFLFLSFFLSFFLPSFFSFFLSLRTRNVSLFLSFFLFLRNRHFSFFLSLRNRHFSHFLSFFSFKKTSFFSFSFFLSLRTHHISLFLSFFFFNNSSFFFFSFISFFSLILLLVIFLSLSFFLSLITHHFSLFPLFLNTSHILSLFTSFFLSLKLVIFFFSFFLSFFFSFNYSFFSFLLFYLFSLITLQLFFLSLLLHLFISLNKSFFFFNNLSFFLSFFNSSSFFSFSSFPSFFFFNNLSFSSFLSLITPHFFLSISLSFIFLSFFFFLSFFLNISGLLSYCILCLFLCFFLTTHPTFFLFFFTYYLIFSFSLCLFVSYFLPFCPSFYPPTSILLLSFILVFFFLPSFLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EEV6</accession>
    <name>A0A812EEV6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_69623</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005098">
        <property type="protein sequence ID" value="CAE1319227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EEV6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="176"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="213"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="261"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="388"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="440"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="477"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="515"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="545"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="566"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="573"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="586"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1319227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="613" mass="71237" checksum="54A9E74FB43C7A31" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EFM7</accession>
    <name>A0A812EFM7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_70364</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005152">
        <property type="protein sequence ID" value="CAE1320097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EFM7"/>
    <dbReference type="OrthoDB" id="10664879at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1320097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="304" mass="34233" checksum="E8439365C7FA2E98" modified="2021-09-29" version="1">MTIISLRGLCFCWRIIAAVISPYDLKSDLHSELFTQMKFYHTIIFTFSFSISSLKIILLLFTFFHCFHFTPHSLLSFFSYPRHLSILSFVSKNLLSHYPSIYLSIYLSIYLFYQASIIAPGPRPLHHGLDPHTMSSTLAPWPRPSHQGLNPTPMAMTLTPGPRPSTLAPGPLPSHHGLDSHTMASTLTPWPRPSHQGLDPRPSHQGLYPRTMASTLTPWPRPSHHVLDSHTMASTLTESQEEKWVLQCIVGPVRFTDSSEPTAARFDNNVTSVVLIIADNEGNLREHCNDVHALPEAVCQHQLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EFY5</accession>
    <name>A0A812EFY5_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase A2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SPHA_74562</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005434">
        <property type="protein sequence ID" value="CAE1324895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EFY5"/>
    <dbReference type="OrthoDB" id="6276451at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06094">
        <property type="entry name" value="RP_Saci_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000130">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon opus-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001995">
        <property type="entry name" value="Peptidase_A2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034132">
        <property type="entry name" value="RP_Saci-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50175">
        <property type="entry name" value="ASP_PROT_RETROV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A2" evidence="3">
        <location>
            <begin position="50"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="184"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAE1324895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="231" mass="26217" checksum="D3F2725227B8C2A0" modified="2021-09-29" version="1">MPEAVKPSTTHAKSKPYPQLKSRTEKQCGRMLVPPNLRRLFYVWDRNNGFNFLVDTGAAISVIPPTNRSALKPTPFQLRAANGSPIETYGNKELTLNINLRRDFKWSFTVADVRIPLLGADFLAHYNLAVHMKTRTLSDNMTTIKITGIPSSFNTTRISVATQHDPHYVEILRRYKHLTQPIKPTDAGDHQTQHHIKTTGQPAYSRPQRLPPHKLAYAKKAFEELLADNIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EIZ5</accession>
    <name>A0A812EIZ5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_72101</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005293">
        <property type="protein sequence ID" value="CAE1322091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EIZ5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="312"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="362"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="385"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="410"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="444"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1322091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="479" mass="58902" checksum="7D423C201ED2B19C" modified="2021-09-29" version="1">MFTFFLSFFFLSFFLSLFLSFFLSFFLSFFLFLSFFLPSFLSFFLSFFFFSFFLFFLVILFLSFFSVQYSFFFSFPSIFPVPYFFYILSFKFSFYFIFSTFSYVYLFLFLLFSFFLSFFLSFFLSFFLSFFCQTLFLSFSPRPIVFISFFISSFLSFFLSFFLSFFLSSVQYFLSFFLVILFLSFFSVQYSFFLSPSLYFLFHISFIFFLLNFLSISQHFLLLISLMFTFFLSFFFLSFFLSFFCQTLFLSFSPRPIVFISFFLSFFLPFFLSFFLSFFLSFFSDIIYLFFFPFLFCQISFLFSVFFLPVQYFFIFFLFFLSIFHFFLFLCFFLSFFLSFFLSFFLSFFCQILFLSFSSRPIVFLSFFLSFFLSFFLSFFRYYFFLFLVFLSFVRYYFFLFFLSSFFPIVFFLSLFFFFFLSFFLSFFLLSDIISFFLSPSNSFSFFLSFFLSFFLSFFLSFFLSFTIYIYSVLASSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EJ58</accession>
    <name>A0A812EJ58_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_73463</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005380">
        <property type="protein sequence ID" value="CAE1323639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EJ58"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1323639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="200" mass="22481" checksum="F3DF461846E6DC66" modified="2021-09-29" version="1">MCVFFLFITSCLCVFAPLSLLPLPPSLSSLSLSLSIYLTVCFCLSLSLSISLSIFLFLSLSFSLFLSLSFFIFLSDFLSLSLSLMLSFSHFIYFSFFLSFYLFLYPSLFLSPSFSFSVSISLFISFFLSFSPFFSLTFSLFQFPCHSLSHFISLFLPRYHSLSLSLSLSLSLSLSLSLSYAVILLLQIAFSISLPLPPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EKZ5</accession>
    <name>A0A812EKZ5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_74361</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005425">
        <property type="protein sequence ID" value="CAE1324666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EKZ5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1324666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="244" mass="28201" checksum="9FB1B9205E70D1DC" modified="2021-09-29" version="1">MEIVFSLFNSFAFYILSPFILSLLTLSYSFSLFLSLFSSFSLSLSLSLSLSPNFFCSLHLSLSLLCVSLLHISVSLCYTLPSSRTLTKFSYRHSILPTTFSSSPTLFFCQIPEIKLILGHTLPSLYLSISFSLHPIYLTLESLSFSPSFLSSFFFLSFLRLKLIPISFFLYFFSFFPLFSDCFFCIFFLFHFPRLYPCLDELKLYFPIVFLTHFLFFHSFTASLTFSICLFFTPLCQPHLTDPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EMD8</accession>
    <name>A0A812EMD8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_76370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005488">
        <property type="protein sequence ID" value="CAE1326791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EMD8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1326791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="234" mass="28270" checksum="3DE78624C37F9C12" modified="2021-09-29" version="1">MYKELTLIQLENLSHNIYLSDSFHYLSISFISLSLYLSHSVHYLSIYLILFIIYLSIYLILFIIYLSHSFHYLSISFCSLSIYLSFLHLSSIYLSIYLSITFHSLSIYLSIYLSIYYILFIIYLSIYLSIYLSIYYILFIIYLSIYLSIYLIHFHYLSIYLILFYLSIYLILFIIYLSIYLILFIIYLSIYLILFIIYLSIYLILFIIYLSIYLSHSFHYLSISFFSLSIYLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EME7</accession>
    <name>A0A812EME7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_73468</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005380">
        <property type="protein sequence ID" value="CAE1323668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EME7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="314"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="344"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="374"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="406"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="542"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="575"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="606"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="634"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1323668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="662" mass="82459" checksum="1E0B3938CA69CA2B" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EPG1</accession>
    <name>A0A812EPG1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_79550</name>
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    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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            <taxon>Metazoa</taxon>
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            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
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            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005571">
        <property type="protein sequence ID" value="CAE1330207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EPG1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="237"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="330"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="342"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="370"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1330207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="399" mass="45594" checksum="F80257B3E7AB5B21" modified="2021-09-29" version="1">MITVVSTSLSLSLSLSLYLSIYLSIYLSLYLSIYLSTPLPPSFMYFTPTLHCDPFPLLLLHSSPISEDKTKPISLSLSPSLSLSLSLSLSCSLSLALSCSIYLSLSLSLQIYIQLIYIYIYFSLSRDLPLSPPLLLSLLLTFTLRSLSLSLSLSLSLSLSFHLLPFTFYISLHFSHSLFLVLLISFFSFPLCLSIYLFFSFRFFSFFHTNFLVFSFLLLLSLSHFCLFIPLIIYLILSLTLSFSLFLFNFHQFSYILLLISSSLFSPFLSLYLSYSFTLSLSLNLSLSLFNSYQLSYIPYFSLNLFPSHVPHRHFVSLFTSHSVFLYFYLIQTNFLISSSLLLISSAFSTFFVSLSLPLSHILFLFNSYFLYSLSLLIYSLFSPLFVSLSLSFSRFILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ERQ6</accession>
    <name>A0A812ERQ6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_78362</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005537">
        <property type="protein sequence ID" value="CAE1328753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ERQ6"/>
    <dbReference type="Proteomes" id="UP000597762">
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    </dbReference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
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            <end position="62"/>
        </location>
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        <location>
            <begin position="92"/>
            <end position="117"/>
        </location>
    </feature>
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        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
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        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1328753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="278" mass="32754" checksum="56BD3836AB8ECE34" modified="2021-09-29" version="1">MNVQKDSSKHEVEAKLLDKWEKIETVTLSVHIYLSIYLSIYLSHSVRIYLSISFCSYLSIYLRKTMRAAVFPFFPDKSGFLQPPIHSHPPSFFLFHPLFTVFLYVSLSSCLLLFEFLPPTPVPHFYISEHLFLICLSHFSLFENHSSTCNISFCTSNFPIYLSIYLSIYLSIYLSIYLSHSFHIYICFSKFISLSPLHYLSIYLSIYLSIYYLSIYSYIYICFSNLSIYLSIYLSIYLSIYLSIYLFISPSHSYYLSIYLSIYLSIYLSPNAFLEQRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ES83</accession>
    <name>A0A812ES83_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_79400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005566">
        <property type="protein sequence ID" value="CAE1330027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ES83"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1330027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="233" mass="27542" checksum="36102528F918CFA6" modified="2021-09-29" version="1">MTSSSSSSSSSSSSSSSSSSSVSLQDLLSISLSSFPSINHGIKIFLSFFLSFFLSFYLFFSPSSPMFNYFFLFFFFLFFLSFFSFFQSRPHVIPLLFICLSFQFYPMFKYFSFFLAYFFLPSNFGHCSTISFFLFVFLSFCLSFFLSFFRFRPLLSTSFFLSFSSKVQSFFFLSLKFLHLFIFLFYYIHFFLLKFAVFVSSFHSLFCYYFLFSFFFIVFPLSSLSIFFTLLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ESE6</accession>
    <name>A0A812ESE6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_79138</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005558">
        <property type="protein sequence ID" value="CAE1329691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ESE6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1329691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="193" mass="21773" checksum="8743BD4AD247DA4B" modified="2021-09-29" version="1">MTILPFTEDGQARFLSLFLLHPTPLLNFFNLSISLFCLSSHFLYTLYNPCLNINLSPPTLSLSLYFSLYIPIFLSVSPPPSYNFNLSLLFSTIPHTPLCIFFLFYNPVTSLLFLLPPTTSAFKNYCLSSPTFSYACGLFSRYANLTVSLCLSPLSSLHTTTFSPVYIHASLSVTPFFRHLCISLPYIPIFRAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ESH7</accession>
    <name>A0A812ESH7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_81593</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005639">
        <property type="protein sequence ID" value="CAE1332551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ESH7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="321"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="365"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="401"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1332551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="472" mass="55710" checksum="07FBFB96C74CE07C" modified="2021-09-29" version="1">MYCSYFFSFLLDFSAHWSSFFFFLFSFLSFFLSFFLSFFLSPPLLYFLPDILSIYGCPPKYISILKLLHDDMRAIFPADNHQREQFQPPPRFLLVFFFLSLRTLAHGHTHAYILFYDFFSTLFLLNPLIFSHPLLKSETNFIFPVCPLPLSYTSFSLFPALFSFINFSFSLLNTLTTIYFTLRVFQIFSILYFFLYLSSSSSSSSSSSSSSSSSSNPPSFFLYSFISYTLLLHSRSYHSIYRHVISIYLSIYLSIYLSIYLSIYIYIYIYIYNNFISIYWDPLRFSGLLTGRAPLFTPHYRHMSAPGRSLFKLFFKFPKSFILFSFFFFFFSFYLFLLNLAHHFYCLSLGLSLQFTRFFSFSPPILSLSTYVSISLSLSLISFITLSLATHNIISLSDYSSFYSFFCFVSIFFQFFLSSPTNFYHKFLQGNFNRARISGYKCHTSIFPIFFFHFRGQFNHNIPCYFSFNSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ETF9</accession>
    <name>A0A812ETF9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_76737</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005496">
        <property type="protein sequence ID" value="CAE1327201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ETF9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="334"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1327201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="357" mass="39668" checksum="8A525A0C57DB9AD0" modified="2021-09-29" version="1">MHIKSLSLSPSLSLSLALSIYLSPSLLLLFVSPSVYHWYSPFSHAILLSLLSLSLSLFVTVLFFSPFITVTLPSLSSLLCLLSLSVTVTILCLSLPLLLSLLSHSYFLFSLSLFLSIYHFSILCLPLSLLLSLLSQSYFPFSLSLSLSLSVTVLFFLSLYHCYSPFSLNLTLSSLSFSLSLLLSFVSLYHCYSPFFPSLSHTLSFPSFSANVTILSLSLYHCYSHSLSLNLTFPSLSLCVTILSISFLYHCYYPSSISLLFSFSLLLSLSLSLSDTVTILSLSLYQLHFLLSPTVTFPSSSLSHSDTVSILSLSLSLSLTSDLSIYLSIYLSSFRWVLFWLGLQAILSYSIYKYHLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EV78</accession>
    <name>A0A812EV78_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_80861</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005612">
        <property type="protein sequence ID" value="CAE1331751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EV78"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1331751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="218" mass="26524" checksum="9819F1555136CDF8" modified="2021-09-29" version="1">MLREKQNVISVLGESKQPAIIYLSIYLSIYLSIYLSRYLYLSIYLSIYLSISVSSSIYLGISIYLSIYLGIFIYQSRYLYLSIYLSIYLSIYLSIYLGIFIYLSRYLSIYLSIYLSIYLSRYLHLSILVYLSIYLSIYLSIYLFREKERERERERMRQDIIKEYNFPITHSIYLSIYLSIYLERKRQRERERSKMYVVSNMQNYEYEIRKPYICACNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EYJ4</accession>
    <name>A0A812EYJ4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_80055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005589">
        <property type="protein sequence ID" value="CAE1330809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EYJ4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="279"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="348"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="381"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="416"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1330809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="460" mass="53360" checksum="3ACB7ADB99F77BA4" modified="2021-09-29" version="1">MFLITPGISFVKKVFDISYFLLRIWILFKQNNISFPRSLHPALHFLFDSSFLLTSFTHFLLCGCLSILLYLPTSHPASFFSLSILLPFLSPSRPPFFIPLYYSLPNFFTFLSLSPLFTPSFLSLYSSLPSFLFHALLSLYSSRPSFFLFFPSFLPSSRHPFFLSSSLSSFPFPFFPFFLLRAILSFSLFFPFFLLRAILSFSLFFPFFLLRAILSFSLLFPFFLLRAILSFSLLFPFFLLHAILSFSLLFPSSFLFFFPAFLLFFLSILPFLPSSRPSFFLSILPFLPSSRPSFFLSTLPFLPSSRPSFFLSILPFLPSSRPSFFLFFPFFLLPPFFLSLYSSLPSSFFLSISFLFSIFLFFLSSFFTPFFLSLYSPLSPFFTPSFLSLSLSFLLRSFVPSFLAPSRLHLSILPPFLSYSCTPSFISFFLTHPSFLSLPSFNSPFHWPPFYIILFFQIPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AKB2</accession>
    <name>A0A812AKB2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_1879</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000054">
        <property type="protein sequence ID" value="CAE1146643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AKB2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <begin position="477"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1146643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="497" mass="57850" checksum="D9CB312B8D9B4A43" modified="2021-09-29" version="1">MFCLPIYLSIYLSIYLSIFISIYLSIYLSIYLSIYLSISVCSYLSIYLSIYLSIYLSLFIIYLSIYLSIYLSIYLSSPDMYLVLTSIYLSIYLSIYLSIYLSIFISIYLSIYLSIYLSIYLSHPDIYLSIYLSIYLSIYLSIHGHLVIPFSLSLSVGNAFFCFVLSIYLSIYLSIYLSIYLSSPDIYLVLTSLSLFLYLSIYLSIYLSIYLSIYLSRRTSNKLESKITLSHSLSRSPSLSLSLYLSIYCQSLSIRRILIYTLSIYRCLLTICQSFCGYSLYVCLSIYLSIYLAMSNHYLCIYLCIYISVYIYSLPKSTHYLSIYLYLLISIYLSIYLCLLTICQSFCGYSLSIYLSISLSLSIYLSMSNHYLCIYTFLYIYIYSLSKSTHYLSIYICSYLSIYLSIYLSIYVYSLSVNLSVATHYLSIYLSIYLFIYLSVSIYLSIYSTHYLSIYLSIYLSIYYVCLYLSIYLSIYLSIYLSIYLSIASCYLSAVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AL47</accession>
    <name>A0A812AL47_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_1075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000029">
        <property type="protein sequence ID" value="CAE1142632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AL47"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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            <end position="33"/>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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        <location>
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            <end position="765"/>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAE1142632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="769" mass="93029" checksum="E4FC7212FCC99073" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ANV2</accession>
    <name>A0A812ANV2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_3909</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000597762">
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAE1153552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="273" mass="32181" checksum="D18FDF3A78B3289D" modified="2021-09-29" version="1">MVYFQIYLSIYLSIYLSIYLSIYLSIYLSILFYIFLIYLSIYLSIYLSSSDLTQYFPYLSIYLSIYLSILFSSDLSLSFPYLSIVFRSNSVFSLSIYLSIYLSIYLSCSLKIYLFPFLIYLSIYLSIYLSIYLSIYLSSSDLIQYFPYLSIYLSIYLSTSKNRAHAILQLVWFLLLFSIFCSVGESTVAGIVGGRLLTQKRIQSQLQHFLFSSFLSLSFYPSFYSLFLRTLRISILIYFDPYLYISFITFNLASPFYLFSFSFLLSDICFFPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AQ36</accession>
    <name>A0A812AQ36_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ENAH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_2652</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Lophotrochozoa</taxon>
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            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000076">
        <property type="protein sequence ID" value="CAE1149197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AQ36"/>
    <dbReference type="OrthoDB" id="31170at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017124">
        <property type="term" value="F:SH3 domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000697">
        <property type="entry name" value="WH1/EVH1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11202:SF22">
        <property type="entry name" value="PROTEIN ENABLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11202">
        <property type="entry name" value="SPROUTY-RELATED, EVH1 DOMAIN-CONTAINING PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
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    </feature>
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        <location>
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            <end position="249"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1149197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="250" mass="28446" checksum="FAB95B93D1B1ADB1" modified="2021-09-29" version="1">MIYDDSNKKWVPSGVSQGLSKVQIFQHVTNNTFRVVGRKLQDHELSGYRLIDTPSYISQTILLSFLLLFLPFFPPPPLPSFLSSSSSSFLSFLLLLFLPFSPLPSFLSSSFLSLLFLPFSPLPSFLSSSFLSLLFLPFFLSSFLPFFLSSFLPFFLSSFLPFFLSSFLPFFLSSFLPFFLSSFLPFFLSSFLPFFLSSFLPFFLSSFLPFFPPPSFLPPSFLSLLLPFFLSSFLSFSPPSFLSLLLPFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AUX1</accession>
    <name>A0A812AUX1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">T-lymphoma invasion and metastasis-inducing protein 1,Protein still life, isoform SIF type 1,T-lymphoma invasion and metastasis-inducing protein 2,Protein still life, isoforms C/SIF type 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_4859</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000158">
        <property type="protein sequence ID" value="CAE1156544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AUX1"/>
    <dbReference type="OrthoDB" id="8059989at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001331">
        <property type="entry name" value="GDS_CDC24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055230">
        <property type="entry name" value="PH_Tiam1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043537">
        <property type="entry name" value="Tiam1/Tiam2/Sif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46001:SF3">
        <property type="entry name" value="PROTEIN STILL LIFE, ISOFORM SIF TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46001">
        <property type="entry name" value="TIAM (MAMMALIAN TUMOR INVASION AND METASTASIS FACTOR) HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23014">
        <property type="entry name" value="PH_Tiam1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00741">
        <property type="entry name" value="DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="2">
        <location>
            <begin position="135"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="578"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="663"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1156544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="732" mass="82098" checksum="514195889F811A68" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AW09</accession>
    <name>A0A812AW09_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_6605</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000215">
        <property type="protein sequence ID" value="CAE1160850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AW09"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1160850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="207" mass="24289" checksum="0678374AC0C2269C" modified="2021-09-29" version="1">MHQSDLTPCHYFLYVWADETYKTHPRKIDELEVIFTLLSIYLSTYLSIYLSIYLYIYIYILFLLATVVFRTEERGMINWISGEGEIEIASYFFLSFLFFFFFFHSFFLSFFFSAFSRAPFKPRSISCTLFKPPTSFCTPFKPPTSSRTPFKRPTISCTPFKPPTSSRTPFKRPTISCTPFKPQPVLGPFSNQQPVLAPTSRIDEEQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AWZ1</accession>
    <name>A0A812AWZ1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_8456</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000273">
        <property type="protein sequence ID" value="CAE1165429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AWZ1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1165429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="152" mass="16721" checksum="32DA6A3D6FC5255D" modified="2021-09-29" version="1">MSVLSVSVCASVLSVPVCTSVLSISVCMSVLSFSVCTSISSISVCTSVSSVSVHLSHLFVSIFIFARHPQISINHFQQILYSTGCLHLPYHKSPLNTSLITFFLLKKEKKQVIPPSLSFSHTLCFFFNILLLLLPLFPLFFSSSPTTTLLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AX17</accession>
    <name>A0A812AX17_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_6651</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000217">
        <property type="protein sequence ID" value="CAE1160983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AX17"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1160983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="227" mass="25919" checksum="6C0AF55BCA847C4D" modified="2021-09-29" version="1">MILFRKSRFQTKPLIPFSFITSLSLSLSLSLIINHTLSFWFSFSFTPLLSSSLLFFLTLFLSSYFSLLLSISITSPLFILSLCLSMLFSLHLPIFFLFLLSLPHNIFCVFFLFVSLLLSQLSFSLAILVVHFIHFLSSHDYLFFSLTFIVSSSLAHSILSLFICCFPLFVFFSFSFPYYLSLFYSCCFSLLSLFFFSFSFSSSSSSSSLSLSLSLSLSLHCFFTSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AXS3</accession>
    <name>A0A812AXS3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_5744</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000189">
        <property type="protein sequence ID" value="CAE1158916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AXS3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1158916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="249" mass="28825" checksum="0C080D1BC9B7527B" modified="2021-09-29" version="1">MQTSFSATHQFGPRICPNLIIILAQGYVSTRQKIGVCLSIYLFESIYLSIYLSIYLSIYLSLSISIFFESLSIYLSQSVHFYLFLVTIYLSIYLSIYLSIYLSISVCPFLSFLSHYLSIYLSIYLSIYLSIYLSLSISIFFESLSIYLSIYLSIYLSIYLSLSISIFFESLSIYLSIYLSISVCPFLSIYLSIYLSISVCQFLSISIYLSIYLSIYLSQSVNFYLSIYRSLLSVLFFFTPLKCSKEQRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AYC4</accession>
    <name>A0A812AYC4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CYP4B1</fullName>
            <ecNumber evidence="4">1.14.14.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SPHA_7526</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Farmed</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.1" evidence="4"/>
    <dbReference type="EMBL" id="CAHIKZ030000241">
        <property type="protein sequence ID" value="CAE1163005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AYC4"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF201">
        <property type="entry name" value="CYTOCHROME P450, FAMILY 4, SUBFAMILY B, POLYPEPTIDE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="424"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="511"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="546"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="2">
        <location>
            <position position="770"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAE1163005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="850" mass="97221" checksum="05F1A0D8501D40C7" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AYF5</accession>
    <name>A0A812AYF5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_6708</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000219">
        <property type="protein sequence ID" value="CAE1161071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AYF5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1161071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="332" mass="39299" checksum="540629183BFD0CBC" modified="2021-09-29" version="1">MYLLSIYLSIYLCLLISIYLSIYLSIYLSIYLSIYLSFKNHSFYNIQLEIIHHRLLYLKHLSIYLSIYLSIYLSIYLSIYLFQSIHSYLYLNICIYLSLGLIYPPSHLFPSSDSSLFYLSIYLSIYLSIYLSIYLSIYLSIYLFQSIHSYLYLNICIYLSLGLFISIYLSIYFSLYLSIYPPSHLFPSSDSSLFYLSIYLSIYLSIYLSIYLSICFSLFIVIYISIYVSIYLSVCSYHLSIYLFSLYLSIYPPSHLFPSSDSSLFYLFIYLSIYLSIYLSIYLSICFSLFIVIYLSIYVSIYLSVFSYLSIYLSIYLSIYLSIYLSIFFPCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B1M3</accession>
    <name>A0A812B1M3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_9187</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000294">
        <property type="protein sequence ID" value="CAE1167027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B1M3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1167027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="282" mass="33125" checksum="45ECD64269E23F8F" modified="2021-09-29" version="1">MDDEELELSRLDQESLSIYLSIYLSIYLSKSEYIYLSIYLFIYIYLSISVCSNLSIYLFKSAYVCLSVCLSIYLSIYLSISTYISIYLSQSVQIYLSQSVQIYLSVYLNLHMSVYLSISIYLSTYLSIYCYIYIYLCLYISICLFKSIYLSLFKSIYLSIYLSIYLSIYLSLFKSIYLSIYLSISVCSNLSIYLSIYLSIYLFKSAYVCLSVYLSTYLPIYLSLHIYLFIYLSLFKSISVCSNLSIYLSIYLSIYLSIYLSIYLSVRLFISIYLSIFVKNFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B283</accession>
    <name>A0A812B283_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_9509</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000302">
        <property type="protein sequence ID" value="CAE1167533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B283"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="295"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="330"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="353"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="386"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="581"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="605"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="633"/>
            <end position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1167533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="658" mass="75465" checksum="E0F382D117D23817" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B294</accession>
    <name>A0A812B294_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_9427</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000302">
        <property type="protein sequence ID" value="CAE1167554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B294"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1167554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="170" mass="19205" checksum="6DB48818182E065A" modified="2021-09-29" version="1">MANLLLPFFFFPFNWLFLIFFFIYSSLTGISSTLISSPITNALFFVPILTFIYSPFVSHSFLVFPSLTFSLAPLPVFVPPTFTHSLTHASPQFIPPSITSLLVLFLPCSLPHASLFYSFFIHSSFSCSSLFHPLFLTQSLPSFTAFPSHSSLMSLPHLFLSSFYSITFHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B2P6</accession>
    <name>A0A812B2P6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_10227</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000330">
        <property type="protein sequence ID" value="CAE1168768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B2P6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1168768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="263" mass="31702" checksum="D105AB868DA28D5A" modified="2021-09-29" version="1">MYISIYLSYFISISLPIYLSIYLYIYIYQTLYINHSIHLYINHLSIYLSIYLSIFFNPSYLSLSPYLSIYTHSYLSVFVRSYLSIYLSIYLSIYIYIYIYIYIYKYIYLSIYLSIYLSIYLSIYLSISVCSHLSIYLDLLFIIYLSIYLSIYLSIYLSEYLSLFIIYLSIYLSIYLSIYLYIYIYRKLFISITVSIYLSIYLSIYLSIYLSIYLSIYISITTYRKRFSSSVVHPTSNRSSSLLFSHSCWTFLGRDYSVEWSCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B340</accession>
    <name>A0A812B340_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein winged eye,BAH and coiled-coil domain-containing protein 1,Trinucleotide repeat-containing gene 18 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SPHA_9755</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000312">
        <property type="protein sequence ID" value="CAE1167949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6426227at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04714">
        <property type="entry name" value="BAH_BAHCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20469">
        <property type="entry name" value="Tudor_TNRC18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052429">
        <property type="entry name" value="BAH_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048924">
        <property type="entry name" value="BAHCC1-like_Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056841">
        <property type="entry name" value="TNRC18_BAHCC1-like_SH3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12505">
        <property type="entry name" value="PHD FINGER TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12505:SF24">
        <property type="entry name" value="PROTEIN WINGED EYE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01426">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21744">
        <property type="entry name" value="BAHCC1-like_Tudor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24912">
        <property type="entry name" value="SH3_TNRC18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00439">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="199"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="230"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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            <end position="318"/>
        </location>
    </feature>
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        </location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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            <end position="407"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="2">
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            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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            <end position="477"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="497"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="BAH" evidence="3">
        <location>
            <begin position="1159"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="552"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="686"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="735"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="854"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1024"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="156"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="563"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="741"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="771"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="795"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="856"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="915"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="946"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1025"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1042"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1081"/>
            <end position="1093"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAE1167949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1287" mass="144401" checksum="952DD222F3B474EA" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B3Q7</accession>
    <name>A0A812B3Q7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SMG5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SPHA_9989</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000320">
        <property type="protein sequence ID" value="CAE1168341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B3Q7"/>
    <dbReference type="OrthoDB" id="5920073at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005697">
        <property type="term" value="C:telomerase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018834">
        <property type="entry name" value="DNA/RNA-bd_Est1-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019458">
        <property type="entry name" value="Est1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045153">
        <property type="entry name" value="Est1/Ebs1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696:SF7">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696">
        <property type="entry name" value="SMG-7 SUPPRESSOR WITH MORPHOLOGICAL EFFECT ON GENITALIA PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10374">
        <property type="entry name" value="EST1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10373">
        <property type="entry name" value="EST1_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Telomerase activating protein Est1-like N-terminal" evidence="4">
        <location>
            <begin position="75"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="DNA/RNA-binding" evidence="3">
        <location>
            <begin position="201"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="430"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="478"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="723"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="440"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="478"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="499"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="526"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="575"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="727"/>
            <end position="740"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAE1168341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="880" mass="99910" checksum="6C2889EF641FE038" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B408</accession>
    <name>A0A812B408_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_10980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000359">
        <property type="protein sequence ID" value="CAE1170190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B408"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="364"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="389"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1170190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="408" mass="45126" checksum="7FB2EEF0B4BEF8F6" modified="2021-09-29" version="1">MLQVQKSLPVMKYYFTTLLSFPSLCHSAPLSPTPVFVPLCPALPTPVFVPLCPALPHPCLCATLPRSPHPCLCALCPLSPTPVFVPLCPAPPPCLCATLPPSPPHPCLCATLPRSPTPVFVPLCPAPPPLSLCPLPLSPTPVFVPSAPLSPTPVFVPSAPALPTPVFVPLCPALPHPCLCATLPRSPHPCLCATAPLSPTPVFVPLPRSPPPLSLCHSAPLSPHPCLCATLPHSPHPLSLFVFLLCPTLPHLSFSLSVLPFLLSTMSLSLCIFQFTLISQPLFIFSLFLLFPLKYFFSFFLAFHNIFHSFFIPYICFNFLHLSSIFISFLCSSSSQIFSLFFFFLKLNLFFDSFSFFLPYFDKIFLFIFTFSLIYFFTSLISFPILKSINNWFFFVSYLITFLLIHDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B9H2</accession>
    <name>A0A812B9H2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_14013</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000474">
        <property type="protein sequence ID" value="CAE1176119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B9H2"/>
    <dbReference type="OrthoDB" id="6819399at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1176119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="325" mass="38316" checksum="55632D3699B9B1CE" modified="2021-09-29" version="1">MITASSFVYLSIYLRLFPIYLYIYVYLSLFISISVCSYLSIYLSQIVHYLSIYPSIYLSIYLSLFTSIYLSRTVHYLSIYLSIYLSIYLSLSVHIYLSRTVHYLSIYLSIYLSIYLSIHLSQTVHYHYLSIYLSIYLLSIYLSIYLSIYLSRSLLTSIYLSIYLSISNCSHLSIYLSHIYLSIYLSSLSFISIYLSRTVHIYLSIYLSISVCSHLSIYLSIYLLSIYLFYLSIYLSIYLSISLFTSIYLSIYLSIYLSQSVHLSIYLSTYLSLFNSFIYLELFIIYLSIYLSIYLSIYLSNFRLSIVATPLLQFIHTYPLSRSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B9N4</accession>
    <name>A0A812B9N4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CHRNA5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_13418</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000449">
        <property type="protein sequence ID" value="CAE1175056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B9N4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="281"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="343"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1175056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="363" mass="43738" checksum="200AB944FB94B53C" modified="2021-09-29" version="1">MEAPQCNKDYFFCLILLANMTVHSIAAAAAAHIVIPDVVFINARLVPMLLSSNPEVLQRAGFFPFRDVFYSFLYFSHQFLFLFFLFFFDLFFPFFPLIVFLFIMRPLFYSLFIFRHLPLIFSFILFLYPSSSSSFFLSFFLSLYFRSSLIPFLLSFFIFSFSSISFPFFYLLTPFLFFFFVFSDIILIHSFIQSYLSFHFSFAFFLFSFFLFPSYLLFRSFLFLFHSFFSRFLLLFFFRLYFLSFFLSFIHSFFLSFFCRLLLLFLTFIHSLPSSSSSSFFFFFFFFFFFFFFRSFTIFLCLSPTFMIVSPLSIYLSIYLSIYLSIYLSIYSIHISLYICNSLLIYLSIYLSIYLSIYLSIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BBK2</accession>
    <name>A0A812BBK2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_14394</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000491">
        <property type="protein sequence ID" value="CAE1176877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BBK2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="290"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="380"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="409"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="435"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="463"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="492"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="523"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="558"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="584"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1176877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="632" mass="73702" checksum="963E74653A92DAC8" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BFI2</accession>
    <name>A0A812BFI2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_16514</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000581">
        <property type="protein sequence ID" value="CAE1227731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BFI2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1227731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="230" mass="26193" checksum="13CE5A83F1BF2395" modified="2021-09-29" version="1">MLTVFFFFYASSPPAPNETLFFSFSFNFSLSFSLSFLIPSLSLFLSLFLSYPLSFTFSFSHSYLLSFSLSLSLLFFLSLSLTLDFSLFPSLSLFLSLSLFLDHFSLSLFLSVFFSFPLSFTFSFSHSYLLSFFLSLSHLHSLFLSFSLSLTLTFSLSLSLTLDFSLFPSLSLFLSLSLPRSLLSLFFSLSLSFSHFLYLFFSLSLSHSCFLSFLFLSLSQECRSGNDILF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BGG8</accession>
    <name>A0A812BGG8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_16352</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000573">
        <property type="protein sequence ID" value="CAE1227347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BGG8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="30"/>
            <end position="48"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="169"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="273"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1227347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="301" mass="35711" checksum="6D117852B2FC2187" modified="2021-09-29" version="1">MFFLFIPLFINVHSVHLSRDSLRNDIFSQTSVSCFFLFSFFTFLSRNVSIISFSTLLHSFLFYFLIRFLSLQTYVITFIDSQLQPFLNFNFPYLIHAVCYLFFFFSLCSHFSLTHSLTDILLTLSFLCFYFWFCLLVFPFFYNSLSLSLSLAASPSVPFPCFLPTYYFLKHSLSGISFLLPITVSSLTLFLFFSFEFPYISSLSLSHRHSHTLCHLFLLFLSLFLKPLFRSHTLFLTLSDYHRCLFFLIPFYGSFYLRHFASFVLSHSHPLTLSYTFCIYIFPLFSHPYFFLHLYFSLIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BHE1</accession>
    <name>A0A812BHE1_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial</fullName>
            <shortName evidence="7">Glu-AdT subunit B</shortName>
            <ecNumber evidence="7">6.3.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SPHA_16716</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Farmed</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-glutamyl-tRNA(Gln) + L-glutamine + ATP + H2O = L-glutaminyl-tRNA(Gln) + L-glutamate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A, B and C subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the GatB/GatE family. GatB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.-" evidence="7"/>
    <dbReference type="EMBL" id="CAHIKZ030000592">
        <property type="protein sequence ID" value="CAE1228215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BHE1"/>
    <dbReference type="OrthoDB" id="1722066at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030956">
        <property type="term" value="C:glutamyl-tRNA(Gln) amidotransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070681">
        <property type="term" value="P:glutaminyl-tRNAGln biosynthesis via transamidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00121">
        <property type="entry name" value="GatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017959">
        <property type="entry name" value="Asn/Gln-tRNA_amidoTrfase_suB/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006075">
        <property type="entry name" value="Asn/Gln-tRNA_Trfase_suB/E_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018027">
        <property type="entry name" value="Asn/Gln_amidotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004413">
        <property type="entry name" value="GatB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023168">
        <property type="entry name" value="GatB_Yqey_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017958">
        <property type="entry name" value="Gln-tRNA_amidoTrfase_suB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00133">
        <property type="entry name" value="gatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004012">
        <property type="entry name" value="PRK05477.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004014">
        <property type="entry name" value="PRK05477.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659">
        <property type="entry name" value="GLUTAMYL-TRNA GLN AMIDOTRANSFERASE SUBUNIT B MITOCHONDRIAL AND PROKARYOTIC PET112-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659:SF0">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02934">
        <property type="entry name" value="GatB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02637">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00845">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="GatB/YqeY motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01234">
        <property type="entry name" value="GATB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 7 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asn/Gln amidotransferase" evidence="8">
        <location>
            <begin position="398"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAE1228215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="549" mass="61945" checksum="B45B94BF81C0FBCA" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BJ50</accession>
    <name>A0A812BJ50_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">SPHA_21280</name>
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    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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            <taxon>Mollusca</taxon>
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            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
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            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000780">
        <property type="protein sequence ID" value="CAE1238422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BJ50"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134:SF22">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134">
        <property type="entry name" value="OS08G0543275 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="92"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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    </feature>
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    </feature>
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        <source>
            <dbReference type="EMBL" id="CAE1238422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="496" mass="57097" checksum="D4570558946F002B" modified="2021-09-29" version="1">MQVKIKTFFFSLVLDLFLFFLFTPSLSIYVNLFISIYLFLSIYLSMSICSYLSIYLSIYLSIYLSISLCQSVHIYLSIYLSISLCQSVHIYLSISLSLSIYLSLYVNLFISIYLSISLCQSVHIYLSISLYLSIYLSLYVNLFISIYLSIYLSIYLSMSICSYLSICFSLSIYLSIYLCQSVHIYISISLYPSIYLSIYLSLSLSLCQSVHIYLFLSIYLCQSLHIYLSISLYPSIYLSIYLSLSLSLSLSMSICSYLSVSLYLSMSICSYLSICFSLSIYLSIYLSIYLSIYLSLYVNLFISVCFSLSIYVNLFISIYLFLSIYLSISMSICSYLSIYVSLLISIYLSIYLSMLICSYISKSVHIYLSIYLSIYVNLFISIYLFSLSIHLYLSLSLSLSLSMSICSYLSVSLYLSMSICSYLSICFYLSIYLSIYLSISLCQSVHICLFLSIYLCQSVHIYLSVSLYLSIYIYVNLFLSIYLCQSAHIYLSIYLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BJ63</accession>
    <name>A0A812BJ63_ACAPH</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
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        <dbReference type="NCBI Taxonomy" id="158019"/>
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                <person name="Bekaert M."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">Farmed</strain>
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    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="CAE1227794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BJ63"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="entry name" value="ZCCHC10"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13491:SF0">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 10"/>
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    </dbReference>
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        <source>
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    <sequence length="774" mass="91472" checksum="AD1A25794DC19D1C" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BLV9</accession>
    <name>A0A812BLV9_ACAPH</name>
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        <submittedName>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
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        </submittedName>
    </protein>
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                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
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    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </evidence>
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        <source>
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    <sequence length="298" mass="34801" checksum="5681D7D5085212B9" modified="2021-09-29" version="1">MEILAALNNPLWLICRKTNQTKTNLSIYLSIYLSYLSITVCSYLTFYLFIYPFISISFCLYLSIYLSIYLSIYLSQSVHIYLSIYLSIYLSIYLSIYLFHSVDIYLSITVCSYLTFYLFIYPFISVNLILFISIYLSHSVDIYLSIYLSIYLSIYLSIYLSHSVDIYLSIYLSIYLSIYLSIYLSHSSVDILLSIYLSIHAYLSIYLILFISIYLSIYLSIYLSIYLSIYLSISSIDIYLSIYLSIYLSMISIYPLIFIYLSIYLSIYLSHSVHIYLAITVSSSLSLFFYVSQAVSIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BNA1</accession>
    <name>A0A812BNA1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_22080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000813">
        <property type="protein sequence ID" value="CAE1239901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BNA1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1239901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="223" mass="26887" checksum="B86B0512E0168E07" modified="2021-09-29" version="1">MKLRILLSFYFPVLLLFFIFALNVYAQYSLSLTLSLPLSLCCILCCSFSLFLPSLSFIHHSFTRSFLTKLFYYPRYLPYFLFLNFSFVFLLYSVFFSFFLSFFLSYFFSLFPFFSSFLTLYFSHFFLSFFLLSLFFLPVSSFFLSFFLSFFLSFLNLFPSFSICFISFVLFFFLSSFLSLFISFLLSFNLSFISISFIIAFFFFFLRFSFFFLRSFLSFFLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BPI0</accession>
    <name>A0A812BPI0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_24440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000912">
        <property type="protein sequence ID" value="CAE1244736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BPI0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1244736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="363" mass="44656" checksum="47CA3D909D161A5A" modified="2021-09-29" version="1">MPMLCRVGVEKVVLDARPTRTAKKKIFTHSFFLSFFLSFFHFFLSFFLSFFLSFLRFLFFLSFLRFLFFLSFFLFSFCLSFFHFFLSFFLSYFSFSFFLSFFLSFFLSFLLFFFIYFLLFLSFFLFSFFLSFFLLLFFLSFFFLSFVFPFLSFFLSFFYFSFFLFSFYLSFFHFFLSFFLSFFLSLFSFFLSFFLSFFHFFLSFFLSYVFFSFFLSFFFLSFVFPFLSLFISYFSLSFFFFSFFLSFFHFFLSLFISYFSFLSFFLSFFLSFFYFSFFLSFFVIFMAANFFYFLSIYLSIYLSIYLLIFIAGNFFYLSIYLSIYLNVVRNELSIIRLTINPISLATDYSTLSHPANMLKSLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BQ01</accession>
    <name>A0A812BQ01_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_20774</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000763">
        <property type="protein sequence ID" value="CAE1237449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BQ01"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1237449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="275" mass="32126" checksum="049870D354EE6A5F" modified="2021-09-29" version="1">MLTIGTFLSLESIQPVPIYLTTFFLSFFLYFFLSFCFCLYMSIYPSIYLSVCSYLSQSSVHIYLSIDLSQSVRYLSIYLSIYLSIYPSLFISIYLSIYLSIYLSIYLSLPVCSYLSIYLSIYLSIYLSIYLSQSVHIYLSIYLSIYLSIYLSISVCSLSIYLSIYLSIYLSIYPSLFISIYLSIYLSIYLALTVLPFYLSFCPYLSIYLFIYLTVSFRSFSFSLFISIYLSHTVRSIYLSIYLSIYLSQTVHIFLSIYPFIYLKLFISLSLSLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BSB2</accession>
    <name>A0A812BSB2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_21830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000802">
        <property type="protein sequence ID" value="CAE1239488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BSB2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="297"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="330"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="386"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="409"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1239488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="443" mass="52357" checksum="DB1B937CF34B5687" modified="2021-09-29" version="1">MSFLSNKCFLSSFFFYSFFPLFRHNYSFCFPPLSFFLSFFLSFFFLSSYTLISDYSYLSHFDPIYLSIYIYLSIYLSIYVSLFLSQTCLIHLSILFDFTLNFIVVLFFFLSFFLSFFLSFFLSFFLFLLSYICSFLFSTLFLPSFLSFFLSCFYLFQFPPLSPALPPPHYLHFILFFHTLFYFSPFFAYTTTSFSPKLCHPLFFRVNFSIPSLYYHHPLLLLLLFSSSFSSPPLCLSSSSSSLSIYLSISACFYLTISTPIYLSIYLSIYLSIYLSIYIYIYTHTHIYSYLYMSLHIYLSIYLSIYLSIYLSIYLSICCNLFISIHPSIYFNLFISIYLSIYLSIYLSISPFIAICSYLSIYLSIAICSYLSIAVYVYLIFSQPSILFNFFLFSFFLFFLSFQICSYSLLLMCLTTKSAISLTAIVILFSRQHHPFFPPDRYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BSM1</accession>
    <name>A0A812BSM1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_22073</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000813">
        <property type="protein sequence ID" value="CAE1239912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BSM1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
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        </source>
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        <source>
            <dbReference type="EMBL" id="CAE1239912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="463" mass="55755" checksum="9FA3C6394E1B4063" modified="2021-09-29" version="1">MSFFHSFFLSFFSLFLLCLFLSIVFILHILLYFHILLFFNLSFFLSFFSFFLFTFSILFLTLFIFLYAFLIFLFFLSFFFLSFFFLALMTFYQTLYFFFLSVTLSTPVLYICLQFLVPYFRVYSFTPQLLFSFHHEFLPVFLKFSFLHGYIILFVSIYLSIYLSIYLSIYQRLFISIYLSIYLSIYLSIYLSIKGCLYLSIYLSIYLSIYLSIYLSIYLSITLSRSIYLSIYLSIYLSIYLSIYLSKAVYIYLSIYLSIYLSIYLSITLSRSIKGCLYLSIYLSIYLSIYLSIYLSIYLSIYDFVQIYLSIYLSIYSSIYLYKAVYIYLSSIYLSIYLSIYLSIYLSLCPDLSKAVYIYLSIYHLSIYLSIYLSIKGCLYLSIYLSIYLSIYQRLFISIYLSIYLSIYPIFQDFCFSYLFMKFISLAQIVFFHSFFLSFFLSFFLSFFLSFFLTRFLLFYSFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BUW1</accession>
    <name>A0A812BUW1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_22589</name>
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    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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            <taxon>Sepiidae</taxon>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="532" mass="62652" checksum="22A6EA2A83AE9417" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BVV3</accession>
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        <submittedName>
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        </submittedName>
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        <name type="scientific">Acanthosepion pharaonis</name>
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            <taxon>Sepiina</taxon>
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            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAE1246180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="332" mass="40613" checksum="2A8E24369F2795D2" modified="2021-09-29" version="1">MSALSSYFHLYCIHNVSLYVTLFFFFTTFSFFLSFFLFCIFLPIFSFLSFLPVSLYISFFCFRPFLIFLFLSFFFCYFSLPICFFLLDSFTYTSLALTYFYSFFLSFLYFSPYIFYCAFLLFPLDITLFCLRVVFIIFYSYYLFFTLILCIFTDFLYFWVFIFLSIFSFLLVSVYNFLLFLSIFNLSFFSFLSLLLFFFLFDFFFLLRCILPSFVLACFSSFPFFLSFFLHFSAQIFFLCFSSRFFVYFFILLFPIFILSSFSLSFLLSFLLSFFLSFSFLISFFFFLSFVFSFYFLSSFYFLSFFSRHFFSTSIVSFYFFILFFIFFLILY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BWK6</accession>
    <name>A0A812BWK6_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">5'-nucleotidase</fullName>
            <ecNumber evidence="3">3.1.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SPHA_26810</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Farmed</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate</text>
            <dbReference type="Rhea" id="RHEA:12484"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18254"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
            <dbReference type="EC" id="3.1.3.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 5'-nucleotidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.5" evidence="3"/>
    <dbReference type="EMBL" id="CAHIKZ030001025">
        <property type="protein sequence ID" value="CAE1249821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="7722975at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008253">
        <property type="term" value="F:5'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="NT5E isoform 4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="5'-Nucleotidase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="5'-Nucleotdase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575:SF24">
        <property type="entry name" value="5'-NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="5'-NUCLEOTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02872">
        <property type="entry name" value="5_nucleotid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01607">
        <property type="entry name" value="APYRASEFAMLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="8">
        <location>
            <begin position="10"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="5'-Nucleotidase C-terminal" evidence="9">
        <location>
            <begin position="229"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAE1249821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="292" mass="32204" checksum="3503CF9AAFD92209" modified="2021-09-29" version="1">MVLFSCLLQCLGNHEFDKGIQGLVPFLQNVTFPVLAANINITGIPELASVKKRIKLKLGGEWIGIVGYITVETPMLSNPEPVTFMDEVESVQREVNELLKENVTKIIALGHAGYWVDKKVAKEVKGLDIVVGGHTNTFLYTGNPPSSEKPDGEYPTVIKQDDGEICLVVQAYAYGKYLGFLQVTFDPDGRLRSWNGNPILLDKTVIPDPAILAKMKPFQRQLTKLVNKVIGETSVLLNGDSQCRLEECNLGNLIADAMVGWYARKPEPDSWNKYAISIVNSGSIRTSIEPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BYK2</accession>
    <name>A0A812BYK2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_25045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000946">
        <property type="protein sequence ID" value="CAE1246143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BYK2"/>
    <dbReference type="OrthoDB" id="10071313at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1246143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="676" mass="75025" checksum="302D757F03E15318" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BZ94</accession>
    <name>A0A812BZ94_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_26375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001007">
        <property type="protein sequence ID" value="CAE1248982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BZ94"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="310"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="340"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="372"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="401"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="435"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="468"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="501"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1248982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="525" mass="60857" checksum="56F9AE8F6DDDC87E" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C0E1</accession>
    <name>A0A812C0E1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_27046</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001039">
        <property type="protein sequence ID" value="CAE1250343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C0E1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1250343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="157" mass="18956" checksum="875D072586270493" modified="2021-09-29" version="1">MRLTFPRAIKQEAKSNNTATYTLSIYLSIYLSIYLSIVVDDNTKRFLVVCKNFLPLFLLILLLNFPFFYFFSFFFFLIIPIYFIAFFSFSYHFISSVFFFLASFHICFFLISLLYVPLFHMILFRLLLPVPISFSSFFFIFPFFYSVVLLHYPPWRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C0G9</accession>
    <name>A0A812C0G9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BTBD9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_26230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001001">
        <property type="protein sequence ID" value="CAE1248590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C0G9"/>
    <dbReference type="OrthoDB" id="9997739at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008344">
        <property type="term" value="P:adult locomotory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048512">
        <property type="term" value="P:circadian behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050804">
        <property type="term" value="P:modulation of chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14822">
        <property type="entry name" value="BACK_BTBD9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18287">
        <property type="entry name" value="BTB_POZ_BTBD9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.420:FF:000005">
        <property type="entry name" value="BTB/POZ domain-containing protein 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000042">
        <property type="entry name" value="BTB/POZ domain-containing protein 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052407">
        <property type="entry name" value="BTB_POZ_domain_cont_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034091">
        <property type="entry name" value="BTBD9_BACK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46306">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46306:SF1">
        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="74"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1248590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="505" mass="56989" checksum="A2A4ED726AC84E07" modified="2021-09-29" version="1">MSGNGAFTPAVLEPATSSSAGAEANSDEWHVFRKQDMRMCDYHFRRSPAPSGQVDHVSSLSENLGDLIENSEYSDITILVEGVPFKCHKVILAARSEYFRALLYGGMLESQPGTKEIELQNTSAKAFDALQRYMYTGRMNLVEAKEENLLNILGLAHQYGFVELESAISDYLKATLNIRNVCLIYDLANMYNLTSLCQVCKEFIDRNAMDILHSESFYSLSQSSVKELLSRDSFCAQEIDIFDAIYKWSEYNPGLDAGPILEAVRLPLMSMQDLLNIVRPTRLVSADAILDAIKVLTECRGMDLKYRGFLVPEENIATVPHGSQVVRGEMTQALLDGDTQTYDFDRGFTRHPIDGNNGQGIVVKLGQPYIINTIKMLLWDRDMRSYSYIIEVSMDDKDYQRVIDHIPSENVATIQASACVIEGVSRSRNALINGDIRNYDWDSGYTCHQLGSGAIVVQLAQPYMCSSMRILLWDCDERSYSYYVEVSTDQHHWVMVADQRNEACR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C9W4</accession>
    <name>A0A812C9W4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_30382</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001223">
        <property type="protein sequence ID" value="CAE1256807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C9W4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1256807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="204" mass="25024" checksum="2F09E76F2B8AB796" modified="2021-09-29" version="1">MFLSSTSFSSSASSFFFFPLSANISSCFTFSSTFVLSFFLSFFLSFFLSFFNFFFTFYFFFFFYFFFFFFFFYFSSLSSSSFLFLLIFLSAFLSWLFFFFFFFFFFFRPISSIFLYTSISRLISYFLRFFFSLSFNSCFSFRFLATLLLLLLLLLLLLLLLLLLLLSANTFLLPFPDYSRSFFSFLFPFFFFFFFFFFFFFFFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CBJ5</accession>
    <name>A0A812CBJ5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_34771</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001482">
        <property type="protein sequence ID" value="CAE1265605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CBJ5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1265605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="287" mass="30569" checksum="E6EFC05A08E75513" modified="2021-09-29" version="1">MLFASFFLSLSFTTYDEYSLFSKESLQVTRPSFLNYIVFCFFLSPFFLSSLPSFSPLSLLSLLSPFFLSSLPSFSPLSLLFSPLFPPFSPPLLLSSPPLPLLPSLLSSLSPPLLSLSSLPSPPPLLSLPLLSSLSSLSLSLSSLSSPPLSPLLSLPLPPSPLSSLSLLPLPLLPSPLSSSPLPPSPPPLLPLPLPPSSLLSPLPPLSSLSSLLLSSLPLSSPPLSPLPPFLSLLSLPSSLPLSLFSLPFSPLIIFHFFHFSTIFATFSHASLIPLSISLPPLMCKTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CF01</accession>
    <name>A0A812CF01_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_36477</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001596">
        <property type="protein sequence ID" value="CAE1269244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CF01"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="194"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="258"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="307"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="400"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="443"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="474"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="573"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="620"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="641"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="652"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1269244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="681" mass="76227" checksum="C42D1F59F14F8F6F" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CHG4</accession>
    <name>A0A812CHG4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WD repeat-containing protein 47</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_37647</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001680">
        <property type="protein sequence ID" value="CAE1272326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CHG4"/>
    <dbReference type="OrthoDB" id="187712at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040067">
        <property type="entry name" value="WDR47"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19863">
        <property type="entry name" value="NEMITIN (NEURONAL ENRICHED MAP INTERACTING PROTEIN) HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19863:SF5">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="108"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="202"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="333"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1272326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="369" mass="40172" checksum="5D2669ABFBEE2848" modified="2021-09-29" version="1">MQSPNLIDGTPYTGVSSPKGTSPVPAKFNERSPMRTPPKAGSTNKLHYVPVTMLEDVQALRTVAFHPSGSLYAIGSNSKVLRICSFPDIQDIQQSHVTQPANVVFKRTKHHKGSIYCLAWNAQGNLIATGSNDKSVKLTTFSLDTCTADGPEIELTCHDGTIRDVLFMEEIANHSSTLVSAGAGDCSICITDCERGTLVRKMQGHSGHIYSLCQLSSHMFVSGSQDKTARFWDLRASAALTCVPSMEPGSAFASVCVDPSGRLLSSGHEDASVMLYDIRGGRVVQSFKPHQGECRTVRFSMNAYYLLTGSYDQKIALTDLHGDLLRPLPSVIVAEHKDKVIQCRWHPSKLSFVSTSADRTVVCWALPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CJR3</accession>
    <name>A0A812CJR3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_36948</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001632">
        <property type="protein sequence ID" value="CAE1270195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CJR3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1270195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="247" mass="29263" checksum="4C0C7810A30E3858" modified="2021-09-29" version="1">MLSSFFLSFFFLSRSVLYVSIYLSIYLSIYLSFFLNLFPSIYLSTGLSFFLSFFLSFFLSFFLSFFLCSHLSIYLSIYLSIYLSIYLSIYLSTGLSFFPSFLFGSHLSTYILAFFIYLSIYLSIYLSIYIYIYIYIYIYIYIYYFFSSFFLDLFPSIYLSTGLSLFINLFLSISLSIDLSIYVLVFLSSFFSPSVPIYITICWPFFSFLPSLFIYQSVFIYLSIYQLFFQPFFLNNFSPGPKFCIQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CK30</accession>
    <name>A0A812CK30_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_37417</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001668">
        <property type="protein sequence ID" value="CAE1271837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CK30"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="375"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="411"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="447"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1271837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="596" mass="69524" checksum="4D057352DF9B43BD" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CLF8</accession>
    <name>A0A812CLF8_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_36277</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001583">
        <property type="protein sequence ID" value="CAE1268820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CLF8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032350981" description="NADH dehydrogenase subunit 6" evidence="2">
        <location>
            <begin position="29"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1268820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="244" mass="28053" checksum="5D848A497DAE5E16" modified="2021-09-29" version="1">MTSISILLSPLSPLVFSLFLFFTNLCSAPPVASGIYLSIYSLNNNIYLSIYLSSFSEYISLSIYPSYLSLWLTIYLSIYLSIYHYGYLSIYYLSIYLRHFIIYLSIIMTKRSMTVLRPGGETLPLTYLFIYVSLFLIGIRLTDLRLAYTHKCTASRKDRTSFDSVYLSIYLSIYLSIYLSVGRSIDLSIWNCSHCLPDCTISFISVTFCPYLSIYLSILIFVNIYLSIYLSIYLSICVNGYLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CLH6</accession>
    <name>A0A812CLH6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tigger transposable element-derived protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_41287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001979">
        <property type="protein sequence ID" value="CAE1278432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CLH6"/>
    <dbReference type="OrthoDB" id="9909311at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF73">
        <property type="entry name" value="PROTEIN PDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="1">
        <location>
            <begin position="79"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1278432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="222" mass="25821" checksum="984AC69EC95827C4" modified="2021-09-29" version="1">MRWKQANNISFKKLHGESTSADHGSANEWVTNVLPQLFRGYDPKDVWNCDETGIFYKAMPSGSLRFAGEEQSNGTKVPKDRLTMLQFTNMDDSEKQAVVVGKSAKPRCFKNVKTLPFSYFANRKAWMTSQLFTDVMKMFDRKMIAQNRKIILFLDNETYCRVQICQISNCRSCHQTPPVSFNLWIKASFVHSKRIIVGNLFECKSQRSMLHRQCRCPRWPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CLJ3</accession>
    <name>A0A812CLJ3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_39388</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001824">
        <property type="protein sequence ID" value="CAE1275309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CLJ3"/>
    <dbReference type="OrthoDB" id="6819399at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1275309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="294" mass="34585" checksum="C4F2052C54823F31" modified="2021-09-29" version="1">MSIWKYFYTTVCEVFGLIFKQVAENHPEYNLSIYLSIYLSIYLSMYLSLFTSIYLSIYLSIYLICSYLSIYLSIYLSIYLSLFMSISVCSYLSIYLSIYLSIYLSMFISISVCSYLSSYLSISVHIYLSLFHLSIYLSIFYLSIYLSQSVHIYLSQSVHIIYSSIHLSIYLSSIYLSLSHVYLSLFISIYLSISIYLSIYLSLFISIYLSLFISIYLSIYLTIYLSIYLSISVHVYLSLFISIYLSIYLSIYLYLFISIYLSLFISIYLSIYLSIYLSIFHTLQINVYEVKPHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CLP7</accession>
    <name>A0A812CLP7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">EEF1E1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_36079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001568">
        <property type="protein sequence ID" value="CAE1268412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CLP7"/>
    <dbReference type="OrthoDB" id="19141at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043517">
        <property type="term" value="P:positive regulation of DNA damage response, signal transduction by p53 class mediator"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053836">
        <property type="entry name" value="Arc1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042450">
        <property type="entry name" value="EEF1E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44490">
        <property type="entry name" value="EUKARYOTIC TRANSLATION ELONGATION FACTOR 1 EPSILON-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44490:SF1">
        <property type="entry name" value="EUKARYOTIC TRANSLATION ELONGATION FACTOR 1 EPSILON-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21972">
        <property type="entry name" value="Arc1p_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST C-terminal" evidence="1">
        <location>
            <begin position="29"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1268412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="166" mass="19413" checksum="9A2E04ED4E931176" modified="2021-09-29" version="1">MITNKQLHVLGKFLDRPLQLVGDKNDVPILKENGLNVQGYISIAKHITRTSKQHALLGKTPTEKALVDQWLEYVSLHLQDNSETASNLQELNQFLADRVYLLGHFVSLADMLLYFTLHETFNELTFCDKEKYIHVSRWFDNMQYHHNFANMYKLVKFHKTLLYSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CML1</accession>
    <name>A0A812CML1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_38408</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001742">
        <property type="protein sequence ID" value="CAE1273714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CML1"/>
    <dbReference type="OrthoDB" id="10684523at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1273714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="402" mass="44228" checksum="320EA8A8D223F8AB" modified="2021-09-29" version="1">MPINMPITSQESDQWAVPSSASSTILFCLTCYPLPLHLLFSSVSPVILFRLACYPLPLLLFRLTRYPLPPHPLSSSASPAILFRFTFYSLPSHLLSSSASAILFRLTLLFRLIPLPPLLPLLPHLLSPSASPTILFRLTCYPIPPRLLSLPPPCSAFRLTRYPVPPHLLSFSASLFLFRLTCYPLPLHLLFSSVSPAILFRLTCYPLPSHPHPLPPHIVSSASSISSSASPAIPFFRLYSLPSLCYPIHPAILFRFTVLLSSASPPFRLYSLPFTCYPIPPRLLSSSASPPPHPILFRLTRYPFPPHPLPPHLLSSSASPSIPSHLLSSSAFPLPLSSSSASHSILFRLTCSFRFTFYPSSVIFRLLPFSCSASPYPLPPHPSSASPAILFRYSPSLSSSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CML8</accession>
    <name>A0A812CML8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_38113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001724">
        <property type="protein sequence ID" value="CAE1273379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CML8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1273379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="305" mass="35551" checksum="77E5A045B6F66A49" modified="2021-09-29" version="1">MLISVNAKLYCIASFLFLRYTISIYLSIYLSIYLYLGMKANDSQFQESRFIPLFLTPIHPHSLTDSFSFCLCFYSLYLIPVFSLFLSLFIFISLHTKYLSIYLSIYLSIYLSIYLSHSNDYLSISSVHIYHSYSNDYISISVCSCLSHSNDYLSIYLSIYLSIYLSIYLSLFIYIFLSASVCPYLSIYPLLSISIYLSIYLSIYLSIYLSITVNIYLSISSVDVYPILMIIYLSIYLSIYLSIYLSKSVHIYLSVYHSLIISIYRSINPFRSVLLYVSICLPLFVHIYLTLMIIYPSIYLSMCCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CRK7</accession>
    <name>A0A812CRK7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_42139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002045">
        <property type="protein sequence ID" value="CAE1280116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CRK7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1280116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="231" mass="27932" checksum="D7FF02CB3E734E54" modified="2021-09-29" version="1">MFAVRRMCLDSPRNNRFFCPILPSFFSLSLSLSLSLLAPQISFRILFLFYFLSFYFSFFFRPFFCIHVSFFIFESSLTLSLFFSFFFLSFLTAFTIIIHPLLFLQLFQPDKDASFFLSFFLSFFLSFFLSFSHTYHSFFLSFFLSFFLSFFLSFFLDKYPSILSFFFYFSQISILLFSFFPDKYPSLLFLSFFLSFFLSFFLSFQINILLSSFFLSFFLFSFFLSFFFLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CV51</accession>
    <name>A0A812CV51_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_43849</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002223">
        <property type="protein sequence ID" value="CAE1283037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CV51"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1283037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="388" mass="43869" checksum="B73B80F387FAB715" modified="2021-09-29" version="1">MIKFCSSFLLRCFHFFTILILSRVGILINVANVTSTFMFRTVICFFLIPRNGQLSFLIPRNCYLLFPDSKELSAVFSDSKELLSAFSSFQGTVSCLFLIPRNCQLPFPHSKELSADFSDSKELLSAFSSFQGTVSCLFLIPRNCYLPFPHSKELSADFSDSRNCYLLFFLIPRNCQLSFSDTKELLSAFSSFQGTELSAVFFSFQRTVSCLFSSFQGTVSCLFLIQGTVICFFLIPRNCQLSFLIPRNCYLLFPHSKELSAVFSDTKELLSAFSSFQGTGTVSCLFLIPRNCYLPFPHSKELSADFSDSKELLSAFSSFQELSAVFFSFQRTVSCLFFIPRNCQLSFLIPRNCYLLFPDSKKLSAVFSDSKELLSAFSSFQGTVSCLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CVG6</accession>
    <name>A0A812CVG6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_44271</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002256">
        <property type="protein sequence ID" value="CAE1283813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CVG6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1283813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="239" mass="28621" checksum="C80EBCFC30C2263B" modified="2021-09-29" version="1">MYCTFISLCQIVQISLAFVIYLSIYLSIYLSRTVFSYLSIYLSIYLFLPLHIYFFDYISSSFLIFIYLCLFVSFVFLPILIYLYLSMLISIYLSIYLSIYLFQFFIYYFIHISIYISVSIYLYIYLAISHGVTSNPDRGFDIYLSIYLSIYLSIYLSQSVSFYLSIYLSHFFIFCFFLSIYLSIYLSISLFHMYLNLFLSKSIYLSIYLSIYLSIYLSLFLSIYLSLFLSIYLSIYLNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CVK3</accession>
    <name>A0A812CVK3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_40987</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001955">
        <property type="protein sequence ID" value="CAE1278010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CVK3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1278010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="249" mass="28461" checksum="C6C0FB26F2108533" modified="2021-09-29" version="1">MFSHGYEVDTKDLVKDPFSSCFVGSNLPPFVSLVRTFSHTFRWFGPSLLCFVGSDLLSFVSLVRTFPHTFRWFGPSLLHFVGSDLLSSVSLVRTFPIRFVGSDLPHTFRWFGPSPYVSLVRTFSPSFRWFGPSLLRFVGSDLLSSVSLVRTFSPPFRWFGPSPIRFRWFGSSPIRFRWFGPSPIRLVGSDLPPYVWLVRTFLHTFGRLRTRLLSLSHFLSLSLSLSHFLSLSHTFSPSLTHSHTLTGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CX16</accession>
    <name>A0A812CX16_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_45325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002334">
        <property type="protein sequence ID" value="CAE1285218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CX16"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1285218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="361" mass="41345" checksum="13C979BBBEBFC448" modified="2021-09-29" version="1">MPVSLDSVPAKKGILTIRNFLFCFFVTFFFDTFFWFRFCYLFFPKLVFLSFFLLRSFSVCLFFFYFLFDTFVSFRFCYLFFPKLVFLSFFLLRSFFVCFFTFFLIRSFGFVFVAPFSLALFFFLSFLLYSYRFLFRSFSFRSFSNLFVAFFYAFVLRSSVAFFLFDFSKCKSLSIYLSIYLSLSVSLSVCLSLSLSLSFSLSIYLSMSVFLSLSLSLSIYLSIYLSISVCLSVCLSVSLSLSLSIYPSIYLSVCLSLSLSLCLSLPLSIYLSIYLSIYLSLSLSLCLSLPLSIYLSISVCLSLSLSLSLYLSIYLCLSVSLSLSIYLSLSLSLSLSLSLSLSLSLCGCMCQLTKCLDRIVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CXU9</accession>
    <name>A0A812CXU9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_43827</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002223">
        <property type="protein sequence ID" value="CAE1283099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CXU9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1283099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="350" mass="41554" checksum="E946E270C7BC2754" modified="2021-09-29" version="1">MEKCLREVNATLLKEEFQRDNKMLNQLFRSFIRIYVRLSIIVHTGLHYDFYVHFVHYLSIYLSIYLSIYLSIYLSIIFHTSYDFLRSLLCVHYLSIYLSIYLSIYLSIYLSIYLSIYLSIYLCNSLYYLSIYLSIYLSIYLSIYVIHYIIYLSIYLSIYLSIYLSIYLSFIYFIVFPLLGFLSSYPYYFTLAGTDPPPYLSIYLSIYLSIYLSIYLLWSIYLSIYLSIYLSIYIYLSIYPRSFHGSFSCFSTSLFFSCLRFFSVTHLTRIMSIVSHPPLLCLTFFTVFHRPTTRFCHEHDSKCRTIFVIYIAGLHANLEGKKKTLPSFIAIVNDNRKKTTAGRCQPFLSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CY24</accession>
    <name>A0A812CY24_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RP-L4e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SPHA_45882</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Farmed</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002392">
        <property type="protein sequence ID" value="CAE1286240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CY24"/>
    <dbReference type="OrthoDB" id="10259785at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1370.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025755">
        <property type="entry name" value="Ribos_uL4_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_uL4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_uL4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013000">
        <property type="entry name" value="Ribosomal_uL4_euk/arc_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045240">
        <property type="entry name" value="Ribosomal_uL4_euk/arch"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19431">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14374">
        <property type="entry name" value="Ribos_L4_asso_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="Ribosomal protein L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00939">
        <property type="entry name" value="RIBOSOMAL_L1E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL4 C-terminal" evidence="5">
        <location>
            <begin position="276"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="391"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="391"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAE1286240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="452" mass="51369" checksum="B32FA6630CC1AB28" modified="2021-09-29" version="1">MSAVKPLVTVYSEKGETTNNHVKLPSIFLAPIRPDIVSFVHDQMLKNSRHPYCVSEYAGHQTSAESWGTGRAVARIPRVRGGGTHRSGQGAFGNMCRGGRMFAPTKTWRRWHRKINVNQRRYALCSAVAASGITALVESKGHKVQDVVEIPLVINDKVQEYKKTKEAVTLLRQLKAWNDIEKVYKSKRFRAGKGKMRNRRRIMRRGPLIVYEKDNGIVKAFRNIPGVTTINVKHLNLRRVAPGGHVGRFIIWTESSFRKLDNIYGTWAQASKEKTGYNLPMPKMTNSDLSRILKSDEIQSVLKKPNKKVRRYVLKKNPLKNFRVMMKLNPYAAAMKRSAILTQRAQKRLKENTLKKGLTMRKLKKMKEEEFLKKKAKNAEKRIKKLALQKKRLRAKGKRQKKLMKAKAKKLTSSKKGAKPAKKGAKPAKARITPAKPRAAPKAIGQRKAATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D0I4</accession>
    <name>A0A812D0I4_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cytochrome oxidase subunit I profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_45288</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002334">
        <property type="protein sequence ID" value="CAE1285237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D0I4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023616">
        <property type="entry name" value="Cyt_c_oxase-like_su1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50855">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="310"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="371"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="408"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="440"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="467"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="509"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="549"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="577"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="604"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="629"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="655"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="683"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="706"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="732"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="765"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="794"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="829"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="857"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="888"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="927"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="953"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome oxidase subunit I profile" evidence="2">
        <location>
            <begin position="533"/>
            <end position="978"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1285237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="978" mass="118411" checksum="497AEDDC4A450CA4" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D4I6</accession>
    <name>A0A812D4I6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CWC15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SPHA_47212</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Farmed</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CWC15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002548">
        <property type="protein sequence ID" value="CAE1288621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D4I6"/>
    <dbReference type="OrthoDB" id="30179at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006973">
        <property type="entry name" value="Cwf_Cwc_15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12718">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12718:SF2">
        <property type="entry name" value="SPLICEOSOME-ASSOCIATED PROTEIN CWC15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04889">
        <property type="entry name" value="Cwf_Cwc_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="52"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAE1288621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="213" mass="24670" checksum="85302F17E7316C76" modified="2021-09-29" version="1">MTTAARPTFEPARGGRGKGENDLSALSKQYSSRDLPSHNKLKYRQEGQGAAEELRGRDFRKDLEDRERAVREKKDRNRESSGSSKRPRLEPASNLDADYPVDDEDDESDSDDDDDTMELMAELQKIKKERVAEAAKIEAERKVEEERIRKENILKGNPLLNQEKVDFKVKRRWDDDVVFKNCAKGGDDKNSRGFINDTLRSEFHKKFMEKYVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D561</accession>
    <name>A0A812D561_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_50109</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002932">
        <property type="protein sequence ID" value="CAE1294001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D561"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="322"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1294001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="356" mass="42852" checksum="965CFA49E4393353" modified="2021-09-29" version="1">MYFLFVIVYSFFLISIPRFFRPLISFFLSFFLSCPHLFFDSVFLSFFLSFFLSFFLSLPSFILRFRFSFFLSFFLSFFLSFFLSFFLSFYTPAFSFAFFVFLSLFLISTPRFFVRFFLSFFLSFFLSFFLSFFLSCPHLFFDSVFLSFFLSFFLSFFLSFFLSCPHLFFDSVFFSFFLSFFLSFFLSFVHLCFLSFFLSFFLISTPLLFRLLFSSFFLPFLFLHLVFSFASFFLYLLLSFSSLNFLSFFLSFFLSFFLSYNQPDIIHLHGISIYLCVSLFTSIYLSIYLSIYLSIYLSLFISIYLSIYLSQSLHIYLSIYRSIYLSVFSHLSIYLSIYLSIYLSIYLSQSLHIYLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D697</accession>
    <name>A0A812D697_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="13">MMP14</fullName>
            <ecNumber evidence="13">3.4.24.80</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SPHA_47806</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Farmed</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="8">Can bind about 5 Ca(2+) ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M10A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.80" evidence="13"/>
    <dbReference type="EMBL" id="CAHIKZ030002626">
        <property type="protein sequence ID" value="CAE1289724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D697"/>
    <dbReference type="OrthoDB" id="1901267at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0030574">
        <property type="term" value="P:collagen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04278">
        <property type="entry name" value="ZnMc_MMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.110.10.10">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036375">
        <property type="entry name" value="Hemopexin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018487">
        <property type="entry name" value="Hemopexin-like_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033739">
        <property type="entry name" value="M10A_MMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001818">
        <property type="entry name" value="Pept_M10_metallopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021190">
        <property type="entry name" value="Pept_M10A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201">
        <property type="entry name" value="MATRIX METALLOPROTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201:SF291">
        <property type="entry name" value="MATRIX METALLOPROTEINASE 1, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00413">
        <property type="entry name" value="Peptidase_M10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00138">
        <property type="entry name" value="MATRIXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00120">
        <property type="entry name" value="HX"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50923">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="PGBD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51642">
        <property type="entry name" value="HEMOPEXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6 8" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="52"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="150"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="224"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="254"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="291"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="327"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase metallopeptidase" evidence="12">
        <location>
            <begin position="427"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="10">
        <location>
            <begin position="684"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="10">
        <location>
            <begin position="734"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="binding site" description="in inhibited form" evidence="8">
        <location>
            <position position="399"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
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    <feature type="binding site" evidence="8">
        <location>
            <position position="446"/>
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        <ligand>
            <name>Ca(2+)</name>
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        </ligand>
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    <feature type="binding site" evidence="8">
        <location>
            <position position="480"/>
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        <ligand>
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        <location>
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        <ligand>
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    <feature type="binding site" evidence="8">
        <location>
            <position position="492"/>
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        <ligand>
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        </ligand>
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        <location>
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        <ligand>
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        <location>
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        <ligand>
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    <feature type="binding site" evidence="8">
        <location>
            <position position="505"/>
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        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="519"/>
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        <ligand>
            <name>Ca(2+)</name>
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            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="521"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="523"/>
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        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="526"/>
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        <ligand>
            <name>Ca(2+)</name>
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        </ligand>
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        </ligand>
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        <location>
            <position position="549"/>
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        <ligand>
            <name>Zn(2+)</name>
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        </ligand>
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        <location>
            <position position="553"/>
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        <ligand>
            <name>Zn(2+)</name>
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            <note>catalytic</note>
        </ligand>
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    <feature type="binding site" evidence="8">
        <location>
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        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="567"/>
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        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
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            <note>catalytic</note>
        </ligand>
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        <ligand>
            <name>Ca(2+)</name>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="738"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
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        </ligand>
    </feature>
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        <location>
            <position position="740"/>
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        <ligand>
            <name>Ca(2+)</name>
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        </ligand>
    </feature>
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        <location>
            <position position="797"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
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        </ligand>
    </feature>
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        <location>
            <position position="844"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>5</label>
        </ligand>
    </feature>
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        <location>
            <position position="779"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00010370"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR621190-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR621190-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAE1289724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="941" mass="109818" checksum="3479A433457709EF" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D830</accession>
    <name>A0A812D830_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_47672</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002605">
        <property type="protein sequence ID" value="CAE1289462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D830"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="273"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="340"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1289462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="371" mass="43283" checksum="5BFA01D5723F09D5" modified="2021-09-29" version="1">MIVFLVDSIYLSIYLSISAYSYLSFFYLSIYLFSLLRFILLFSPFSLYFPFPSISIYLFIYLSIYLILSIHLSIYPSMHPSIYRSPNPFIHLSIYPSIYLSIYLSLLIHPSIYLSIPVSVYPSIHPSISIYLSIYLPVSKYLSYLSPVYLSIYLSISIYLSLLSIYLSSPLSIYLSISVYLSIYPSIYLSIYLGLFIYLSIYLSISSIIYLSIFIYSSIHLSIYLSIYLSIYLSIYLSIHPSIYPIYLIYLSISVCLSIYLSIYLSISVCLSIYLSIYLSIYLSIYLTTTIISLSLLIRCYFQTIISLSLFRRYFQTIISLSLVRRYFQTIISLSLVRRYFQTIISLSLVRIYLSIYLSIYLSINIQIYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D8W8</accession>
    <name>A0A812D8W8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">EPN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_51545</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003128">
        <property type="protein sequence ID" value="CAE1296616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D8W8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="629"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="688"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="713"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="738"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="288"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="310"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="351"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1296616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="840" mass="91059" checksum="3EA7506A2A8F5571" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DAF4</accession>
    <name>A0A812DAF4_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SPHA_52669</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Farmed</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the RNF181 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="2"/>
    <dbReference type="EMBL" id="CAHIKZ030003305">
        <property type="protein sequence ID" value="CAE1298599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DAF4"/>
    <dbReference type="OrthoDB" id="21204at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16465">
        <property type="entry name" value="RING-H2_PJA1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000127">
        <property type="entry name" value="E3 ubiquitin-protein ligase RNF181"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15710">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PRAJA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15710:SF243">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PRAJA-2 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="204"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAE1298599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="248" mass="27229" checksum="3A3470DEAB3393D7" modified="2021-09-29" version="1">MWVKELNTPQAERDFSLYFFDPKTILLLQSETHSGLDGDTDSADADDEFECDCIHCQQMRDVFSHRPSSQGNEPETAAAAAAAAATAIAASSSPLPTSTASVLLNTGSSGSLSSEHNDWSTSLSEDNPLDINIAELNPLDLLLMRQDARRDMLELMFQNVILQMLAVHPDLLNDQAPPPATQTVIENLQSIHATQEDIDQDASCPICLCSWELNETMAQLPCQHLFHPLCIRAWLVKSGTCPVCRHVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DB79</accession>
    <name>A0A812DB79_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_53151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003358">
        <property type="protein sequence ID" value="CAE1299260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DB79"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1299260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="205" mass="24169" checksum="3510003F52793CCA" modified="2021-09-29" version="1">MKNDGIWLKLFFVIIFACVRRCNLFFFLCFLLSMILSIHQSLLADCFLSFFLNLTFTFSFFIKISLSFFFLSYQSFRLSFFLSFFLSFFLSFFLKISVSIFHCTCFVSLLSLRPSLSFVIFPSLRVSLCLSFSNFLLGPKFTIYLSIYLSIYLSIYLSIYLSIYLSLNNLLEGPWIIQLKGWLLCYSIHYLSIYLSIYLSIYLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DBZ5</accession>
    <name>A0A812DBZ5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_53451</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003402">
        <property type="protein sequence ID" value="CAE1299812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DBZ5"/>
    <dbReference type="OrthoDB" id="6159796at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="253"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="282"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="477"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="486"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1299812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="502" mass="57711" checksum="EEDC513CA2699054" modified="2021-09-29" version="1">MFIFCFLSPFHFVLLGKMQLLLFLLFSTYPLSQPSVNLLFLLFSTYPLSQPSVNLLFLLFSTYPLSQPSVNLLFHLFSTYPLSLSLHLSAFSESAFPSLSTYPLSQPSVNLLFHLLFSSLHLFLLFSAFSQPSVNLLFLLFSLSLSLHESAFPSLLYLTSLSQPSVNLLFFLFSTYPLSQPSVNLFFLLFSTYPLFQPSVNLLFLLFSTYPLSQPSVNLLFLLFSTYPLSQPSVNLLFLLFSTYPLSQPSVNLFFLPCLCFLPWIWTVELSFFISVEQTQTLLYLNSFLLLYSLFLHVNIHLQKHHHDDLCYHILPELTPEEMSEAEKQRSQENLDKDTHCYLAWKMDWKFREILNKKTPNYLQHLKTLPSYDATDSIYQRTKWSHCSMHPPQIHNFFKKLKGVAENPDCKSDGISDTDSIRTEDFESRFTELLVPAPSIGSESQETIVADVGDGAETDDHNDITITKEELLKSMSIEKPPAASIEHSDLHKWLTPDSEKQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DDE9</accession>
    <name>A0A812DDE9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_52046</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003205">
        <property type="protein sequence ID" value="CAE1297474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A812DDE9"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <location>
            <begin position="394"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAE1297474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="440" mass="50673" checksum="31050707F0EA34B7" modified="2021-09-29" version="1">MKRERNVISLSRFLPLTPLCCSVHPLSHYLPLPRDSFSSSLAYLLCLSFSLSLSHFLFSQLFFYLSLFLSLSHSYISFDLLFHYFYFFPPSFLLSLSLSLSLLLSPMPFSQSISLLVSLLLILYPFLVTLLLSLCFSFFIMSFYLLRPIYSVLIFLSLFLSLHFLCSSLPSFLSLFYELSLHDPPLSLSLSLSLTLTPLLLYLSFPSFSLSIYFTSSPNLFLPIFFSPSCLHVTFYYLFSLSLSLSLSLSLCCSFSITLSCNLFLSLYLSQLPHPLPITLVLSFFLILCFAFLFLPLDTLSYSLLMSLYIAFSHTFFPTPLCRISMGPLFIFLSLPNTPLCSSFTLRLQLWHLSITFSLCYLFFSFPHFSPHFYVFLSFFPSLFISISSHFDTLYLTFFLSLSIYLVLLSPLSFSRSLCYFLTNPYTYTESKQIRLSCQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DDQ3</accession>
    <name>A0A812DDQ3_ACAPH</name>
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        <submittedName>
            <fullName evidence="2">NUP188</fullName>
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        <name evidence="2" type="ORF">SPHA_53961</name>
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        <name type="scientific">Acanthosepion pharaonis</name>
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            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
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    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <dbReference type="EMBL" id="CAHIKZ030003453">
        <property type="protein sequence ID" value="CAE1300625.1"/>
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        <property type="term" value="C:nuclear pore inner ring"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:RNA export from nucleus"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Nup188"/>
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        <property type="entry name" value="NUCLEOPORIN NUP188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31431">
        <property type="entry name" value="NUCLEOPORIN NUP188 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
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        <source>
            <dbReference type="EMBL" id="CAE1300625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1756" mass="192496" checksum="03D6CDF4DDA734EB" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DHL7</accession>
    <name>A0A812DHL7_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Tubulin beta chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SPHA_52421</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Farmed</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="11">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003261">
        <property type="protein sequence ID" value="CAE1298129.1"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:GTPase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
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        <property type="term" value="P:microtubule-based process"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="beta_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Tubulin beta chain"/>
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    </dbReference>
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        <property type="entry name" value="Tubulin beta chain"/>
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        <property type="entry name" value="Helix hairpin bin"/>
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        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
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    </dbReference>
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        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
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        <property type="entry name" value="Beta-tubulin_BS"/>
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        <property type="entry name" value="Beta_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
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    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
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        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01163">
        <property type="entry name" value="BETATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00228">
        <property type="entry name" value="TUBULIN_B_AUTOREG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="12">
        <location>
            <begin position="47"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="13">
        <location>
            <begin position="246"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAE1298129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="469" mass="52128" checksum="A17B5D436CC3FF1E" modified="2021-09-29" version="1">MREIVHVQTGQCGNQIGAKFWEVISDEHGIDPTGTYHGDCDLQLERINVYYNEATGGKYVPRAVLVDLEPGTMDSVRSGPFGQLFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVIRKEAESCDCLQGFQLTHSLGGGTGSGMGTLAISKIREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSIHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALSVPELTQQMFDAKNMMAACDPRHGRYLTVATIFRGRMSMKEVDEQMLNIQSKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFVGNSTAIQELFKRISEQFTAMFRRKAFLHWYTDCWLGLLVCEVLVKVPSVKVLSSDLPSLLQKGFSASYEKPKSTSYSQPPLLLLTIQGSQHISSPISECAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DI45</accession>
    <name>A0A812DI45_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_53450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003402">
        <property type="protein sequence ID" value="CAE1299779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DI45"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1299779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="266" mass="31578" checksum="9905A352AB916501" modified="2021-09-29" version="1">MASGRLRHGRGKQYLSIYFHHYFLAIYLFPPLLPCNLSVCPYISIYLSIYLSIYLSIYLSIFIIISLQSIYSHHYFLVICLFISIYLSIYLSIYLSIFTIIYFLVIYRSIYLSIYLSIYLFSPLFLSIYLSIYLSIYLSIYLPIYLSTYLSIFIIISLQSIYLFPPFLPCNLFVHIYLSIYFHNYFLVIYLSIYLSIYLSIYLSIYLSICIIISLQSIYLFSPLLPCNLFVHYLSIYLSICHSSCKQLTDCLEEKHYFLSRCPLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DI69</accession>
    <name>A0A812DI69_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_54081</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003474">
        <property type="protein sequence ID" value="CAE1300792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DI69"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="293"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="374"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="435"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="474"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1300792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="605" mass="69867" checksum="E3680C1BFC266A90" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DKB9</accession>
    <name>A0A812DKB9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_57638</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003891">
        <property type="protein sequence ID" value="CAE1305113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DKB9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="273"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1305113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="297" mass="33966" checksum="C854EEB4B04CD133" modified="2021-09-29" version="1">MSIIMHLRTLSIYLSIYLSFSLFISSYFLSSNPNIHLFSYVSFPCFFCCCLYLFVSSFSLSFFLSLFSFDGIRFTFFFLSYDIFLALLRIYLPSLLSTIPSFPNPFFLPQSLPSSFPAIHFFFLFFPFTSPSLLSVHLFLPSLSSSTSPSFLSSRHSSSSSFPYFFHFLPFPSSFPPFPYFLPSLSSSISSSFLSSRHSSSSSFHYFFISSLSLLPSLPFLTFFLPSLPPFPHPFFLHVIRPPLPSLIFSFPSLLPTFSSLFLPFSLLSSSPHFLNCLILSFFPSFLFLSFFCCFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DL43</accession>
    <name>A0A812DL43_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_58003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003940">
        <property type="protein sequence ID" value="CAE1305626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DL43"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1305626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="172" mass="19784" checksum="A8C8D6ED24D7A8D5" modified="2021-09-29" version="1">MIGFSSGEKCSAIYLPIYQSIYLSLFISIYLSIYLSIYICSALLGLTPIKKTYLSIYLSIYLIFSLSISFSSFSIYFYLSIYLSIYLSHFQSDYLSHSLSIYLSIYLSIISSSVLHILFLSIIVVCSPSFIHLSFDLKPFLPSSFSPSLFKYIFSLAYFLFLISTFKRIRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DLG6</accession>
    <name>A0A812DLG6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Basic immunoglobulin-like variable motif-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SPHA_58536</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004007">
        <property type="protein sequence ID" value="CAE1306257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DLG6"/>
    <dbReference type="OrthoDB" id="31113at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16171:SF12">
        <property type="entry name" value="BASIC IMMUNOGLOBULIN-LIKE VARIABLE MOTIF-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16171">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-G CELLS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="224"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="94"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="576"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="576"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="607"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAE1306257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="619" mass="70112" checksum="3B3F20CB5C62F5E0" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DSC2</accession>
    <name>A0A812DSC2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_59344</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004111">
        <property type="protein sequence ID" value="CAE1307334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DSC2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1307334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="247" mass="29430" checksum="D4409BD59EE9327F" modified="2021-09-29" version="1">MSSLAVITFNIFYMLILLLLLLLLLLLLLLLLLLLLLHIVHIITVLTGYIYVSVDFQPSRLSVPDPTTPTLGPSTLYITPSSIISQFFLPLLLFTPFFFFFFFPSFASQISFEEIDFSSFFPFFLSFFFLSLIFLFFFYNFFLSFSFLTYIYFLSLFLFFLIHSFSILSFFLSFFLSYINILISYSIFIFYFLPLELFFFHLFIPLQFFSFLFFSSSLFPFSYGIYIFSHYLLFFHFFVVTCFSISF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DSD1</accession>
    <name>A0A812DSD1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ILKAP</fullName>
            <ecNumber evidence="8">3.1.3.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SPHA_59025</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Farmed</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="8"/>
    <dbReference type="EMBL" id="CAHIKZ030004081">
        <property type="protein sequence ID" value="CAE1306850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DSD1"/>
    <dbReference type="OrthoDB" id="10264738at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000156">
        <property type="entry name" value="Integrin-linked kinase-associated serine/threonine phosphatase 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF699">
        <property type="entry name" value="INTEGRIN-LINKED KINASE-ASSOCIATED SERINE_THREONINE PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="7">
        <location>
            <begin position="374"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="320"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAE1306850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="665" mass="75596" checksum="110A577D8F3A5C98" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DSY0</accession>
    <name>A0A812DSY0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PARP10_14_15</fullName>
            <ecNumber evidence="1">2.4.2.30</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_60119</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.30" evidence="1"/>
    <dbReference type="EMBL" id="CAHIKZ030004159">
        <property type="protein sequence ID" value="CAE1308213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DSY0"/>
    <dbReference type="OrthoDB" id="9903237at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15225">
        <property type="entry name" value="INTERFERON-INDUCED PROTEIN 35/NMI N-MYC/STAT INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15225:SF8">
        <property type="entry name" value="RNA-BINDING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23085">
        <property type="entry name" value="RRM_PARP14_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1308213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="422" mass="47193" checksum="127D770DEA0C36FE" modified="2021-09-29" version="1">MDLDELQLFFENGRRSGGGKIEKEAERDTCTNLVEITFASEEVAKHVVERSPLTYNNCTLEVSLKQPLKTDELPKENTQKFSAHSDQRTIIVYDVPKALHSDEVMLYFENKRSSRGGKITDFDFDRKNGIKITFDSSTVARNVIEKKNHVIDNNPVKVSMYVPPVMEEKKVLICDVNENISSDALKNFVESKVNVDVQHVEKLKHGIWLISFPDKIDFEELKQICKSQSKKYISETYPKFKKSDIHYVKGKDNSVADALSRFDVNTVQDSPYQSGPDSRGPGMRMLPSLEVLAKTSLQLKEFPQVDQAQQPTQHPAAVVSNSLFQGYLPKVIRSPLFKAPLTSLFATVPSPALLHFQLTPAASSTPAASSTPASPAALQQLPAPCSFQHPLQFPDPCIQCPADVQRPQLVRTHLLMTLSSAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DTP9</accession>
    <name>A0A812DTP9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NUDT8</fullName>
            <ecNumber evidence="8">3.6.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SPHA_61241</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Farmed</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="8"/>
    <dbReference type="EMBL" id="CAHIKZ030004322">
        <property type="protein sequence ID" value="CAE1309579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DTP9"/>
    <dbReference type="OrthoDB" id="10262892at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:coenzyme A diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03426">
        <property type="entry name" value="NUDIX_CoAse_Nudt7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045121">
        <property type="entry name" value="CoAse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992:SF11">
        <property type="entry name" value="MITOCHONDRIAL COENZYME A DIPHOSPHATASE NUDT8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992">
        <property type="entry name" value="NUDIX HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAE1309579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="174" mass="19575" checksum="19F23E201D64580F" modified="2021-09-29" version="1">MCTVNGELSILYTLRSVHLQYGRGEISFPGGMMDDSDKTLTETALRETHEEIGLPTSSIDVWGSMLPLTDSQATRQITPVISYCGEIEPSSMQFNKNEVSLVFTRTIAQLCQPYLQGTTQFRTGYTLPIYLGKPQRIWGLTALTTHQFLSLLAPENYKFKLQHQRPLLGTKAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DU60</accession>
    <name>A0A812DU60_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cytochrome oxidase subunit I profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_60840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004253">
        <property type="protein sequence ID" value="CAE1309049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DU60"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023616">
        <property type="entry name" value="Cyt_c_oxase-like_su1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50855">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="279"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="320"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="354"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="396"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="432"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="466"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="498"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="524"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="560"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="586"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="611"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="636"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="674"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="701"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="735"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="822"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="852"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="883"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="916"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="943"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="976"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1011"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome oxidase subunit I profile" evidence="2">
        <location>
            <begin position="169"/>
            <end position="687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1309049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1053" mass="125570" checksum="D6494B3D24856D4D" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DVK5</accession>
    <name>A0A812DVK5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">NRCAM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SPHA_59876</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004150">
        <property type="protein sequence ID" value="CAE1307931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DVK5"/>
    <dbReference type="OrthoDB" id="6244967at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098632">
        <property type="term" value="F:cell-cell adhesion mediator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070593">
        <property type="term" value="P:dendrite self-avoidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000005">
        <property type="entry name" value="Neuronal cell adhesion molecule"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000032">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075">
        <property type="entry name" value="BASIGIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075:SF14">
        <property type="entry name" value="CELL ADHESION MOLECULE DSCAM2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
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    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
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            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="949"/>
            <end position="971"/>
        </location>
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        <location>
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            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="178"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="287"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="380"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="475"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="565"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="11">
        <location>
            <begin position="745"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="11">
        <location>
            <begin position="847"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="981"/>
            <end position="1069"/>
        </location>
    </feature>
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        <location>
            <begin position="983"/>
            <end position="995"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1003"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1021"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1056"/>
            <end position="1069"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAE1307931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1147" mass="130874" checksum="E53A1A87FEAE5EF4" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DXU8</accession>
    <name>A0A812DXU8_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heme-copper oxidase subunit III family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_61131</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004296">
        <property type="protein sequence ID" value="CAE1309397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DXU8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000298">
        <property type="entry name" value="Cyt_c_oxidase-like_su3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50253">
        <property type="entry name" value="COX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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            <begin position="18"/>
            <end position="39"/>
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        </location>
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        </location>
    </feature>
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        </location>
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        <location>
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        </location>
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    <feature type="domain" description="Heme-copper oxidase subunit III family profile" evidence="2">
        <location>
            <begin position="159"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
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        <source>
            <dbReference type="PROSITE" id="PS50253"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAE1309397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="712" mass="90500" checksum="CDEC143F47F56118" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E1P7</accession>
    <name>A0A812E1P7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_62752</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
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        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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            <taxon>Metazoa</taxon>
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            <taxon>Coleoidea</taxon>
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            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004489">
        <property type="protein sequence ID" value="CAE1311326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E1P7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1311326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="206" mass="25023" checksum="26416F59F8459FFA" modified="2021-09-29" version="1">MYLQTKIKNENSSSFSHFFFLFFPIFHCFHSYFSFCFLFQIFPFIHFCLPFSFPHFFLNLSFLGHLSFLSYLSFTFSLFYLSTIFLLPHPPFHLFNILSLFFFFIFFSFHLLFGHLRFPSFPSFIFFLSFLFSVFPLLPFYHFPSSSSPFPLFFHLFYIFLPLLLHILSFSFFFFFISLSLLCFTSSFISFFSFLIFSLIFYFFPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E470</accession>
    <name>A0A812E470_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tetratricopeptide repeat protein 39A,Tetratricopeptide repeat protein 39B,Uncharacterized protein C32D5.6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_67431</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004892">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="43460at2759"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31859">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 39 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31859:SF9">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 39B"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="591"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="591"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1316796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="622" mass="71119" checksum="154D46FA7D34CE79" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E840</accession>
    <name>A0A812E840_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_68451</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004980">
        <property type="protein sequence ID" value="CAE1317934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E840"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1317934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="268" mass="30462" checksum="CEDFD406E656C50C" modified="2021-09-29" version="1">MFSKCIYRISYHIWLTYGFGHHLSWVRIFNPRQDSPSHSSILSLSLTHSLSLFLSYSLTLSISLTHSLSLSLSLTHSLSISLLLSLSLTHSLSLYFSHSLSLLLTLLLTLSLLLTHSLSLTHSLSLSLSYSLSLYLSLTHSLSISLLLTLSISLSLTHSLPQIRYVDILISLCQKNATIIFFQIFQCAFNIRFLFFDSSVTFYEYICQHSQVSILRLERVSIGRRKRVEISLSLSLSLSLSLSLSHSGQLHIFEHDFINMQHMFISLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EB34</accession>
    <name>A0A812EB34_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_67553</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004896">
        <property type="protein sequence ID" value="CAE1316990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EB34"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1316990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="171" mass="19329" checksum="445096E7E8843C87" modified="2021-09-29" version="1">MKRSLSILGLLLGFHVTDFLSNRFILKQKKRLNFIDKIVLPLCTNDTSNYIYLSIYLSIYLSIYLSMCLLFFTNLNPHWERPVSRLHPPIPQSQPLECTTFFFTRDDRLPIPVAETLVILSEPTSLPFPISVGVLPLLTAFLGLDSCGVSPEELCLSIPCGKSIDHDPFPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EBF7</accession>
    <name>A0A812EBF7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_69979</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005114">
        <property type="protein sequence ID" value="CAE1319652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EBF7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="322"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="357"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1319652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="387" mass="47997" checksum="C0ACCE1F64694D32" modified="2021-09-29" version="1">MCPWEYQKIKLILLLFISSNISYFIRFLHRHQFIFFPLVSVFSLSLDFSSILDLFFFNHSFFILLLLFLFLCAMYLFLFSFTVFTLSFTLSFFIIFFSTFCYFFLQQFFITLIFLIHQILPFLFPFLPFSFSFFFFPLNIFFVLFYSFFLSFSISFFFFQLFLPFSFSFFFFPLNIFFVLFYSFFLSFSISFFFFQLFLPFSFSFFFFPLNIFFVLFYSFFLSFSISFFSFSFFFLFLFFLFFSFKHLFCIILFIFSFLQHFFLFLSAFSSFFLFFLFFSFKHLFCIILFIFFFPSAFLSFSFSFFFLFPFLSFFFSFKHHFLYYFIHFFFPSAFLFFPSAFSSFFLFFLFFSFKHLFCIILFIFSFLQHFFLFPSTFSSYSINVFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ECC9</accession>
    <name>A0A812ECC9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_69985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005114">
        <property type="protein sequence ID" value="CAE1319658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ECC9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1319658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="155" mass="16833" checksum="98866E30717687E6" modified="2021-09-29" version="1">MSTFLSLSVRVYSWLSLSLCQSLFVAISLSQSLFVAISLSLSESIHGYLSLSESIHGYLSLSESIHGSLSLSLSLSESIHGYLSLSLCQSLFMAISLSLCQSLFMAISLSLCQSLFMAISLSLCQSLFMAISLSLSVKVYSLLLFFLCPTISTIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ECU7</accession>
    <name>A0A812ECU7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_70753</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005175">
        <property type="protein sequence ID" value="CAE1320478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ECU7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1320478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="209" mass="24774" checksum="C7F57ABA55AFD146" modified="2021-09-29" version="1">MSFCSYLSIYLSIYLSIYLSIYLSIYLSTPVCSYLSIYLSIYLSIYLSIYVHIYLPHSLYIYLSIYLSIYLSQSVPIYLSIYLSIYLILFISIYLSIYLSIYLSIYVHIYLSHSLHIYLSIYLSIYLSIYILFISISFCSYLSHSVHIYLSIYLSIYLSIYLSVCIAIYDEITTSDYLKNNKVHIKLFLYRKNCVIPPDEKIFKKHKVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EDW2</accession>
    <name>A0A812EDW2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SF3B2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_71830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005269">
        <property type="protein sequence ID" value="CAE1321780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EDW2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1321780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="158" mass="20057" checksum="9B56AF1A07838C78" modified="2021-09-29" version="1">MFLFYLSFCLFVFFIALFYFLFFLSFFLSFFLSFFLSLSTALSVFYLYAFRCLVYFISFFFLFKLLFFIFIFDFSSFRFIHYFFLMRLFLFFLFYFSLYYIFSFVLFRYMRPRLISLQQIFPPPSYSTDIDLCNFFYLFYYSFFLYYFKFMYPSSFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EFH8</accession>
    <name>A0A812EFH8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_69930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005110">
        <property type="protein sequence ID" value="CAE1319561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EFH8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032701441" evidence="2">
        <location>
            <begin position="21"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="310"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="340"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="372"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="395"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="426"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="454"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="480"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="506"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1319561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="526" mass="64221" checksum="04AEB487DAB59216" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EH84</accession>
    <name>A0A812EH84_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SPHA_73640</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005382">
        <property type="protein sequence ID" value="CAE1323764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EH84"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="188"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAE1323764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="259" mass="29014" checksum="A12F2155226F35EB" modified="2021-09-29" version="1">MWPLNDGSGELSFSLGPLCLWDAADCNSSNCCWLNSLLFWRCALEGKFGEAESSFSSRCRSFGWVGKVEAHTISIKERISVIEHLKNRFMCLTCFSIVSSIIFANLKTILYIYLSQSVINLSIYLSIYLSIYLSICCGFNLSIYLSIYLSIYLSLFWCLVNHMNPHESNPFTLVAPSMPRIESQDGNFSCSHCSRVCRSAGGLKHHMKVHSAANTVSVVSPNANGHECQICSKMCKSLAGQKSHQRVHRRSINRVMAIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EHG9</accession>
    <name>A0A812EHG9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ETV1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SPHA_72408</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the ETS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005320">
        <property type="protein sequence ID" value="CAE1322439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EHG9"/>
    <dbReference type="OrthoDB" id="10067219at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000418">
        <property type="entry name" value="Ets_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046328">
        <property type="entry name" value="ETS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006715">
        <property type="entry name" value="ETS_PEA3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849:SF282">
        <property type="entry name" value="ETV5-RELATED PROTEIN ETS96B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00178">
        <property type="entry name" value="Ets"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04621">
        <property type="entry name" value="ETS_PEA3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00454">
        <property type="entry name" value="ETSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00413">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00345">
        <property type="entry name" value="ETS_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00346">
        <property type="entry name" value="ETS_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50061">
        <property type="entry name" value="ETS_DOMAIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ETS" evidence="6">
        <location>
            <begin position="284"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAE1322439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="363" mass="41912" checksum="879F1500EE26523B" modified="2021-09-29" version="1">MIKPYLFQPPPPVIWYSSSNLKWKYLDTDLIQIDSEFLQDLDQMQEMWLTNAYYSTEEGEQYIPENTTPKSSTFMKVKSEPFADSCHGQLTLATLKQVDFDSGEKNFMTNFYDHSSSSIDSLCSSPCSGKESNAQRLRHSDFNQERLVSCSENRYSHISTRLVPSCYPPSESQSCSPFSWTSAQRFVTQHKFKRESFDKEYSFPFHQNNEHLDHNNMVTVKKETKNLSCIRGSNGGTGTIDLTRDTYPDSCTDKYLREASVAAAAMVTTYPATISTTCQRRGTLQLWQFLVSLLDDPNNSTFIAWTGRGLEFKLIEPEEVARRWGLQKNRPAMNYDKLSRSLRYYYEKGILQKVSGERMIYEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EKK7</accession>
    <name>A0A812EKK7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_77257</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005511">
        <property type="protein sequence ID" value="CAE1327833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EKK7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1327833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="281" mass="32566" checksum="7CCF968CCE3D2C02" modified="2021-09-29" version="1">MLYSPPPAYSLPPSLSLSLSLSLSLSLSLFFSILKVCFFFSCLLFFLLSFFPSFFLSFLLCFSFIFLSFFRLSFLLACSVLEVCYFFCLLFFLLSFFLSFFPISFFLSYFFLSFTLAFFLSRLLYKFIKHNTTFSCFFFISHSFCLSPSPPLSSSLLPPPSISDSFLSKISFSFSPRQFPLLSSPSLFTSLSISQSSSLSFHLPLSFHLSLSFSLSLSRWHAYNRQIFVLLDCLHFSDSQTSAKPFSSSVSNKRYRLIGTSPIFFYWPLPPTRTFWERYFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EKL1</accession>
    <name>A0A812EKL1_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_72577</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005332">
        <property type="protein sequence ID" value="CAE1322640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EKL1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1322640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="159" mass="18849" checksum="1973DA689BA9692D" modified="2021-09-29" version="1">MTITPKESNSLKKDLLALCALSSRLKLERQRQRVYLSTEEDGNGKLKSNQLLRGLLSFISLSFLSYFFFILSLFFFNIHSKFINFSYSFHYSFFVYFSFMFLLSFLLYLFLPHSFFHSVSFPSIPFLFYLFLPDSSLHSFFLPDSLFQSFFIISLQARQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ELH1</accession>
    <name>A0A812ELH1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_77920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005525">
        <property type="protein sequence ID" value="CAE1328340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ELH1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1328340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="245" mass="28767" checksum="0DF46AB222808764" modified="2021-09-29" version="1">MAENSITVNLISFLHIYIVFSFVFKRFFMFIYIYSFIIIHFFLFHSFFSSLLFYVFSIHFFFFLLIFDLKTFSFFFCSLSFPLVFGSKLWSFYTSFSYFFVSLIQKSVFSFFSFALFFSHPFSSKVYSFFLSPNFNSFSLLLFQNLFSCFLTYFIICLSFKKALSLSLSPSIAFQNPLVSILILCFSFLLFILSYNTCFFFLPQLPSTKATIFPPHRKTLFTAAVTPSSQQASAPASFLSIQYLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ES39</accession>
    <name>A0A812ES39_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_81035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005619">
        <property type="protein sequence ID" value="CAE1331915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ES39"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="316"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="372"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="407"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="436"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="471"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="498"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1331915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="609" mass="66489" checksum="BE752E48482411EC" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ET56</accession>
    <name>A0A812ET56_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_76565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005493">
        <property type="protein sequence ID" value="CAE1327029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ET56"/>
    <dbReference type="OrthoDB" id="8963674at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21698">
        <property type="entry name" value="PROTEIN (PUTATIVE)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21698:SF4">
        <property type="entry name" value="PROTEIN (PUTATIVE)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="353"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="384"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="412"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="446"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="483"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1327029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="515" mass="60732" checksum="0705A73E6E5374D8" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EVB7</accession>
    <name>A0A812EVB7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_78456</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005540">
        <property type="protein sequence ID" value="CAE1328839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EVB7"/>
    <dbReference type="OrthoDB" id="9635126at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1328839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="223" mass="26328" checksum="B6E15A0B019DADA1" modified="2021-09-29" version="1">MYLSISLCNIYILFTFCLYLSIYLTVYIYLSIYQSISVYTFIHFYIYLSIAACSYLSVYVYCNLSIYLSIYLSIYLSIYRVLFLSIYLSIYLCLFLSIYLWRTDAIYLSMSILSIFYLSFYLSIYLILSIIYLSIYLSIYLWSSDPIYLSIYLSIHLSIYPSMSIPIYLSMALLSSLSIYLSIYLSICLSVYSYLSIYLWRSDPIYLSMALCSYLSIYLYSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AKV4</accession>
    <name>A0A812AKV4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DRAM2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SPHA_1268</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DRAM/TMEM150 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000035">
        <property type="protein sequence ID" value="CAE1143370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AKV4"/>
    <dbReference type="OrthoDB" id="191706at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019402">
        <property type="entry name" value="CWH43_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050911">
        <property type="entry name" value="DRAM/TMEM150_Autophagy_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21324:SF2">
        <property type="entry name" value="EG:22E5.9 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21324">
        <property type="entry name" value="FASTING-INDUCIBLE INTEGRAL MEMBRANE PROTEIN TM6P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10277">
        <property type="entry name" value="Frag1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="CWH43-like N-terminal" evidence="7">
        <location>
            <begin position="2"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAE1143370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="246" mass="27861" checksum="3CF8E3B00B3305E7" modified="2021-09-29" version="1">MLWLLPLITAVWILGSFIITYVIAVANGRVEPNFPYISYTAIYAPERAIFSQLVNIGAVLLGSTAYVRYIQVKADYPHMSTKMRGCNVASLVLGMLSALGLSMVANFQAKIIQIPHYLGAFFAFGLGTVYCWVQTVITGKIFTRDFNYSRGVLILRIFISISVTIILFIFTATKIFYKKHKFPGSKWNVHRGVYLTSTSTEWLLAICILLYVLSFIAEFRNIRLRFPEIVSTVERSNTMETNHQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ART0</accession>
    <name>A0A812ART0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_3933</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000120">
        <property type="protein sequence ID" value="CAE1153577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ART0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1153577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="277" mass="33662" checksum="260410B6DA7033A8" modified="2021-09-29" version="1">MHFPIKASFFFFSFLWVDNFICVFSIIFFFSFFTHYLFLSFFFFLFLIFIITTHIFCKFSFSLPVSFPTFLSFLFHLSLTLFLSFHSFPLFPIRDISFFLFIHPLFFHEKHLFNFFSFISFFPFIGQFLSLFVFLSFFFPSFFPSFSLSSFSFISFFPFIGKFLYLFFFLFSFLLFLFPFLSFFTFLSFILFIHCHCLLFLHYKHFLPSFFLSFLPSFILSLFYLILFHPLFFPLFSSFYPHSFVLFFDFLFSLILSLSFFGLVWFTSIFGHLSRNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AT55</accession>
    <name>A0A812AT55_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_4542</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000145">
        <property type="protein sequence ID" value="CAE1155749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AT55"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1155749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="250" mass="30119" checksum="A6AEDEFA52010BF3" modified="2021-09-29" version="1">MSFKIKRISFYYCYLHSCSLFSSLSSLLLFLFFLFFLFFLYFFFLVHSSLSSLTFTSSLFSSICFILFLSFSFAPHSLMQFLLSHTLLLILSLCQFLTPTSLFSYKILSVSYHLFMFFLFSLFIFSTLFLLYSSLYISILYIFFTIFLFIPFNLFLQHYFLYIYFLLFFLSFVQSSCSFCIFFFIFYFYLLPMLFLIQLSTYTFYLIHYSLYFSLFLQILHVFYPLFFSFSSHLMLSSFASFSQSLLNFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ATA3</accession>
    <name>A0A812ATA3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_4740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000154">
        <property type="protein sequence ID" value="CAE1156383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ATA3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1156383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="213" mass="24190" checksum="75BC96E5B5AA8840" modified="2021-09-29" version="1">MYLPQSVHYLSIYLSIYLSISGLAVAGLLCTLPLPLPSGSTDQHPHHLLLLPFFFTLPFPTISDQGHSSSVSCRHIPRTLSFLFTFTFSFRPKPLIRQIHPTHPTQPGAHSFPTSETTIFILHPLTPSSLPNVFFRLFPASISLFPTCTFPSLHLSFFLSFFLSFLHVFPTQTFSSNYLYAKLLYLSIYLSIYLSIYLSILICSFIYLSNQDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ATF8</accession>
    <name>A0A812ATF8_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Oxidized purine nucleoside triphosphate hydrolase</fullName>
            <ecNumber evidence="11">3.6.1.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">2-hydroxy-dATP diphosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">7,8-dihydro-8-oxoguanine triphosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">8-oxo-dGTPase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Methylated purine nucleoside triphosphate hydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Nucleoside diphosphate-linked moiety X motif 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">SPHA_4346</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">Farmed</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21">Oxidized purine nucleoside triphosphate hydrolase which is a prominent sanitizer of the oxidized nucleotide pool. Catalyzes the hydrolysis of 2-oxo-dATP (2-hydroxy-dATP) into 2-oxo-dAMP. Also has a significant hydrolase activity toward 2-oxo-ATP, 8-oxo-dGTP and 8-oxo-dATP. Through the hydrolysis of oxidized purine nucleoside triphosphates, prevents their incorporation into DNA and the subsequent transversions A:T to C:G and G:C to T:A. Also catalyzes the hydrolysis of methylated purine nucleoside triphosphate preventing their integration into DNA. Through this antimutagenic activity protects cells from oxidative stress.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>2-oxo-ATP + H2O = 2-oxo-AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67392"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:71395"/>
            <dbReference type="ChEBI" id="CHEBI:172878"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:67393"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2-oxo-dATP + H2O = 2-oxo-dAMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31583"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:63212"/>
            <dbReference type="ChEBI" id="CHEBI:77897"/>
            <dbReference type="EC" id="3.6.1.56"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:31584"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>8-oxo-dATP + H2O = 8-oxo-dAMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:65396"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:71361"/>
            <dbReference type="ChEBI" id="CHEBI:172871"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:65397"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>8-oxo-dGTP + H2O = 8-oxo-dGMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31575"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:63224"/>
            <dbReference type="ChEBI" id="CHEBI:77896"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:31576"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>N(6)-methyl-ATP + H2O = N(6)-methyl-AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67608"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:144842"/>
            <dbReference type="ChEBI" id="CHEBI:172873"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:67609"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>N(6)-methyl-dATP + H2O = N(6)-methyl-dAMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:169976"/>
            <dbReference type="ChEBI" id="CHEBI:172872"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:67605"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>O(6)-methyl-dGTP + H2O = O(6)-methyl-dGMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67600"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:169974"/>
            <dbReference type="ChEBI" id="CHEBI:169975"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:67601"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.56" evidence="11"/>
    <dbReference type="EMBL" id="CAHIKZ030000137">
        <property type="protein sequence ID" value="CAE1154961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ATF8"/>
    <dbReference type="OrthoDB" id="408303at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008413">
        <property type="term" value="F:8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008828">
        <property type="term" value="F:dATP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042262">
        <property type="term" value="P:DNA protection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03427">
        <property type="entry name" value="NUDIX_MTH1_Nudt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003563">
        <property type="entry name" value="8ODP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43758">
        <property type="entry name" value="7,8-DIHYDRO-8-OXOGUANINE TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43758:SF2">
        <property type="entry name" value="OXIDIZED PURINE NUCLEOSIDE TRIPHOSPHATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01403">
        <property type="entry name" value="8OXTPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 24" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="22" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="22" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="190"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Nudix hydrolase" evidence="23">
        <location>
            <begin position="48"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00026103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00026218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00032071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00053094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="CAE1154961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="216" mass="25025" checksum="114B9ECFFD137F62" modified="2021-09-29" version="1">MKVVCAAAESDWERLASLVETAAAARFGFFSGQQRGSSRKKVKMPVKSKKILTLVLIQEARRVLLGMKKRGFGKGNWNGFGGKVKTGEETIEEGAKREVQEECGLIVSELDKVGILKFEFLGNPELLEVHVFSSSSYEGIPKESEEMQPRWFNIQRIPYDRMWPDDRFWFPLYLKGSRFTGYFMLKRMRVFIASFFFFLSFFLSFFLSFFLSFFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AUR1</accession>
    <name>A0A812AUR1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_5473</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000181">
        <property type="protein sequence ID" value="CAE1157942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AUR1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1157942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="217" mass="26949" checksum="54F84B68BC07F6E2" modified="2021-09-29" version="1">MSQSLETSFCDTCYQHLSLKVLFFYLSFFFLFLSLYFFRFFFLSLSFLLTLFTLFFCSLFFYYFFLSFFFLSFFLSFFFLSFFLSFFLLSFFLLLLLFFPFSSVFLSFCIFSFFLSFFLSFYLSFFCTILYFFIWFRILSFFHSLFAYFFLSFAIHFRIFFLSFHLCSFFPFIFHLYNSFFLSFFLSSFFLSSFLSFFLSFFLSFPHLFFICRLSPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AUU7</accession>
    <name>A0A812AUU7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_5905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000194">
        <property type="protein sequence ID" value="CAE1159329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AUU7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1159329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="176" mass="21036" checksum="3C9C2D2277583DAD" modified="2021-09-29" version="1">MDFLLFSSYFPLLDMITSPVFLIYFFLFVSFFDPILFLLFHSLSVFISFFLSLSSFFFLSIFPTLYYSFYLSLFLPFFYHLHLFLLQFSTCYTFSCLYVCFFSLIILFHHANLLSLSPCNSLPFFYFIFLFLSQVLHPLCHIFPFFVSSLLSLYLFLLISNFFSPSLFLLLIHLYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AWI7</accession>
    <name>A0A812AWI7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_5072</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000169">
        <property type="protein sequence ID" value="CAE1157209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AWI7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="172"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="205"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1157209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="269" mass="32040" checksum="2DF35F320E7C2EBD" modified="2021-09-29" version="1">MSIWLNLTAVLLQLRRKDCTKRTISFSTTIMRIHILTRHRWDLFLDITIHNTAFFLCLCVLILPSELYKKAMPGLSAKSVALLASSIIHKFFSFFISSFFFLYFFFLSFFIYFFFLSFFLFFLSFFLFFIYLFFLFFFISSFLSFFLYFLLSFFILSLFLLSFFLYLFLLSFFFLFLSFFISSFFLSFFLYFFLSLFLSFFLSSLFFFLSLFFLSFFIFSLFFLYFFFLSFFICSFFISSSPSFSSSSSSSSSSSSSSSSSSSSSIYVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AX02</accession>
    <name>A0A812AX02_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_7311</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000236">
        <property type="protein sequence ID" value="CAE1162503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AX02"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1162503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="218" mass="25333" checksum="BCA49C5C8EE33174" modified="2021-09-29" version="1">MTYTTSLGKLYDAYGYLYCFMSVKFFQTLLLPLLFLFYAFLFFYLSIYLSIYLSIYLSIYLTLPIISLSLSLYLSIYLSIYLSHPAHYLSLSRSLYLSIYLSLSLYLSIYLSIYLYLSCPLSLSLTSSIYLSISIYLSIYLSISIYPAHLISLSLSIYLSIYLSIYLSIYLSHPAHYLSLSLSLTLSIYLSIYLSIYLSIYRSIYLSIYLISVKKEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AYD5</accession>
    <name>A0A812AYD5_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SPHA_7524</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000241">
        <property type="protein sequence ID" value="CAE1163031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AYD5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="39"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="262"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="307"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="336"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="398"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="428"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="224"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAE1163031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="452" mass="52058" checksum="3408B6F9EC791ED0" modified="2021-09-29" version="1">MFIFAHFLSSFLSLFFVSLFILFFVPLFCLSFLSSFVSLFISLFSPVFCLSFFIFVSLFCLSFLSLFLVPFFVSLFSSLFILFLVSLLSLSSLLFLRSLFSSSVSFSLTHTLYLSTYPTLSLLLPHTCFSLSFISPIKHIYLSIYLSIYLSIYLSIQIYLNLFLSIYISIYLSIYLSIFQSVYPSVLISYYLLIYLIPFHEQHSVYLSPSLSLSLSPYLSIYLSNSTSLILHLFFHCLVYSYLSIYLFSLSPSPFASIYLSIYYIHIYLSIVSVCLSLFIISLSIYLSICLSIYLFYLSVSVSSLSIYLSIYLSIYLSVCLPVYLSIYLSVSTSIYLVYLSIYLSSIICLLSVHLSIYLSICLSVCLSIYLSIYLLAYLSIYLSIYHSLFISLSIYPYLSIYLSIYHSLFISIYHLSISNLSIYCSHLSVYLFVHIYLSIYLSIYLSIYLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B0E4</accession>
    <name>A0A812B0E4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_9095</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000292">
        <property type="protein sequence ID" value="CAE1166861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B0E4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1166861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="180" mass="19599" checksum="96F5CF023DB8618D" modified="2021-09-29" version="1">MGSDHRVPIDQIHSFSYWGLALTMVVSILPSSSAGVTFALSLSLSLSLSLSHTLCLYVFLYPFSPFPFLLSLSLSLSIYLSIYLYLYIYIYIRMVVSKQTSSSSSVKSKSSNSVASESFPRLSAKLASSLSPEQRLSVSVAPSMSLRTGKKPPSTAMELLLSQRSTPENPAWSTSIHGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B0F7</accession>
    <name>A0A812B0F7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_7123</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000229">
        <property type="protein sequence ID" value="CAE1162020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B0F7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
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    </feature>
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            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="366"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1162020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="401" mass="47782" checksum="937560DE5BDE7034" modified="2021-09-29" version="1">MAIGKFDRIVAPAPFSTGFVFLPTYSSFTDILAFHSFAFVSLHILLSFLHLFLSHLQNDSSFPSSSTHFFIASLFKYTLFSLFLLPLTYFLFSFLSFFLSFFLSFFLSFFLSGWLAVCLSVFHVDIFIYVSDRSFFLSSFLSFFLSFFLSFSFMYSSNRQLSILNLSSLLFLQCLLYFSFLFSLVDFYLIHSLYFSFLYLSLYLSFNIFFLSFFLSFFLSFFLSFFLSSIINFAFYFHYQFMLIFSFMTLIVLSFFLSFFPSFFLSFFLSFFLSFFLSYFLSFLFTYSLSLFSYSILDNTFTSARYFFPLLSLPSLFVSLYMFSFKLCLFLIHIDTFSSFCIYFFFILYLSSFFLSFSFILFFPHFIPICCFFFMSSSFPLDFFLCFFHLTLINFHFEVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B428</accession>
    <name>A0A812B428_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_8900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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            <taxon>Metazoa</taxon>
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            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
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            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000287">
        <property type="protein sequence ID" value="CAE1166450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B428"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAE1166450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="737" mass="85474" checksum="41352EBEFBC52902" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B7V1</accession>
    <name>A0A812B7V1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">SPHA_14640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
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            <taxon>Sepiidae</taxon>
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        </lineage>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000501">
        <property type="protein sequence ID" value="CAE1177424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B7V1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
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    </evidence>
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        <source>
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    <sequence length="448" mass="53365" checksum="824E1BEC83B4F1EF" modified="2021-09-29" version="1">MTLVQVHFLSSFFSFLNALTLFPNFLILIHLSIYLSIYLSENIYMFYLSIYLFIFYVRIDGYLFSFPSLSISVCSYLSIYLSISVCSYLSIYLSIYLSIYLSIYLSIYLSQSVHIYLSIYICSHSPFPTLSLSIYLSIYLSIYLSIYLSENIYMFYLSIYLSIYFLYENRQLSILIPLYIYLSQSVHIYLSIYLRIYIYLFYLFYIYQFILYMRIGRYLFSLLPLSLYLSIYLSIYLSIYLSIYLFSFLSPILLFIDLSVFLTFFFLSYFLFFFLSFFLSFFLSFVRSFVPFTSFVSFYPFFILFFNTSPNENHSSFLNTYLSSSILSLSLSLSLSLSLSPILPLSFYSFPFLFFLSSSLLSPSGENKSQQELFAKVNANIMTIKLLLPLRKSLRKQKAVRRTAYTLLKERKKERRRRRRRRRRRLWKNATLTKTRIVFFSPASAFVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
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    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
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            <authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
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    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000379">
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        <property type="entry name" value="ZCCHC10"/>
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        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 10"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="881"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="920"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="953"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="976"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1008"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1049"/>
            <end position="1068"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1171269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1124" mass="126748" checksum="9D17177F51F72C0C" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BAT8</accession>
    <name>A0A812BAT8_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SPHA_13989</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000473">
        <property type="protein sequence ID" value="CAE1176092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BAT8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="72"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="119"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="150"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="189"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="28"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAE1176092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="288" mass="35281" checksum="F934D2BB8976EB6E" modified="2021-09-29" version="1">MLLLRTAARIFTRTEKECMRFRISSFIFFLLFLLFIFDFFLFFFIIFFSSFIFFFLLSILVPTLYFRIISRFFWFILFFFFIAFSFFFSFFLFSFFLCLLSLIYLFLLSLLVRYFSYIFSFFFFSSFLSFSMFFFSSFFVYFSFIRSVKFFLVFLLCIIENALFSLFFFFFLLYFIVSVSSSIPFFLSFFLSFFLSCSYAIFILFHFFLLSLVFLSAFVIVDGDSYSFFLSFLLPLSSFFSFCSYSFLFFFYFTFISPQGRRSPRYQPDIYHSGYLRDKEPVRLWRIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BB30</accession>
    <name>A0A812BB30_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="13">PIGG</fullName>
            <ecNumber evidence="13">2.7.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SPHA_13367</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Farmed</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGG/PIGN/PIGO family. PIGG subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.-.-" evidence="13"/>
    <dbReference type="EMBL" id="CAHIKZ030000447">
        <property type="protein sequence ID" value="CAE1174987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BB30"/>
    <dbReference type="OrthoDB" id="272139at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051267">
        <property type="term" value="F:CP2 mannose-ethanolamine phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16024">
        <property type="entry name" value="GPI_EPT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037674">
        <property type="entry name" value="PIG-G_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039527">
        <property type="entry name" value="PIGG/GPI7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045687">
        <property type="entry name" value="PIGG/GPI7_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23072:SF0">
        <property type="entry name" value="GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23072">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19316">
        <property type="entry name" value="PIGO_PIGG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="344"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="413"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="450"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="483"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="540"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="581"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="612"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="732"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="776"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="domain" description="GPI ethanolamine phosphate transferase 2 C-terminal" evidence="12">
        <location>
            <begin position="447"/>
            <end position="805"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF19316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAE1174987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="816" mass="91980" checksum="F65C4BAE1E8AE75B" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BBI1</accession>
    <name>A0A812BBI1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_13630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000458">
        <property type="protein sequence ID" value="CAE1175435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BBI1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="285"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="401"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="467"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="492"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="556"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="587"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1175435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="625" mass="74385" checksum="EDC2DA55CEEBE342" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BBX0</accession>
    <name>A0A812BBX0_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heme-copper oxidase subunit III family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_16994</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000602">
        <property type="protein sequence ID" value="CAE1228769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BBX0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000298">
        <property type="entry name" value="Cyt_c_oxidase-like_su3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50253">
        <property type="entry name" value="COX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="319"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="382"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="414"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="441"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="493"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="520"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="543"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="573"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="602"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="635"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="664"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="707"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="735"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="765"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="815"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="841"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="874"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="901"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="domain" description="Heme-copper oxidase subunit III family profile" evidence="2">
        <location>
            <begin position="415"/>
            <end position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1228769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="949" mass="112109" checksum="B2B57AFFB02DA94E" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BDJ4</accession>
    <name>A0A812BDJ4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GBF1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SPHA_14717</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum-Golgi intermediate compartment</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000505">
        <property type="protein sequence ID" value="CAE1177611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10258608at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010256">
        <property type="term" value="P:endomembrane system organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00171">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1000.11:FF:000007">
        <property type="entry name" value="Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056604">
        <property type="entry name" value="GBF1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032691">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HUS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF388">
        <property type="entry name" value="GOLGI-SPECIFIC BREFELDIN A-RESISTANCE GUANINE NUCLEOTIDE EXCHANGE FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12783">
        <property type="entry name" value="Sec7-like_HUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23325">
        <property type="entry name" value="TPR_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SEC7" evidence="6">
        <location>
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            <end position="1044"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
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            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
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            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
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            <end position="842"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
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            <end position="1658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1977"/>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAE1177611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="2041" mass="226849" checksum="D8FFF8FDE21E3A3D" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BDS9</accession>
    <name>A0A812BDS9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_15604</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000545">
        <property type="protein sequence ID" value="CAE1225123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BDS9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="366"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1225123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="415" mass="47557" checksum="0E103FA9D2E4DBAE" modified="2021-09-29" version="1">MLSYLCFVFSNIVFIYLSLFLASYLSVCRSVLSNLSIYIIYLSIIYLSQSLHIYSSIYLSISQRASHWTLLLFFFFFFFSFLPFLLPPPPPSFFLLPPSPSSSTSSPPLPPHPPPPPSSSLLLFFLLPSSLLLLLLLLLLLLLPPPPSSFLLLLLPSSPPPPPPSLPPSSSFLLLLLLLFIFFLLLLLLLLLLILLLFSSFLLLLLLLLLLFFFFFVSWFFLFFYFLLLLLLLHLFSFLSLFYSSSFSFILLLLLLLFSTPPPSSSSFCFTLFPSSSSSSSSASFSFSSSLFILSTFFLPSSSFLLLFAAFSSFLTFFFIFSSFFPFASTSSPSFFFFFCFFHSSSSSSSSSSSIFFFFFSNFFFLLLLFNFSFLLLLFLILLFFFFLILLLFFFFFNSFLSSSSFLILLFFFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BEE0</accession>
    <name>A0A812BEE0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_15854</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000555">
        <property type="protein sequence ID" value="CAE1226042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BEE0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="305"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="335"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="363"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="392"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1226042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="421" mass="52203" checksum="0BDC248189073BC6" modified="2021-09-29" version="1">MENFKLRIRCENKRSPAVRFHSFHLFFLSFFFLFLSSFSFLHSFFFFLYFFFTFFIFISLFFLSLFFFIFISLFFLSLFFFSFFIFISLFFLSLIFLFFLYIFNKFYFYILFTFSFFRSLFSYILHFFYLFRFSFFYTFTSFLHSFIISLLIISLLSFPLLYFRFFHSIFYTFASFIPSFIHSPLPFFQSVILSFFSYPLLYFRFIIPSLIPPLLSFALLYFRFFHSIIYIFVSFIPLFIFSLFSFILSYFCFIDSLFYPFSSFIPPLYFHFFHSIIYTFASFILSFILSLLSFHYLYFRFFHSTFYIFAFFIPSFILSLLSFHYLYFRFFHSTFYIFVSFIPLFIFSFLSFHFLYFRFFHSFFYTFASFIPIFIFLILSFPLYTFASFIPLFIFSLLSFPLLYFFFFLLSFIISFLSLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BEY9</accession>
    <name>A0A812BEY9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_16262</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000569">
        <property type="protein sequence ID" value="CAE1227069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BEY9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1227069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="267" mass="32434" checksum="0CAA4799E77829DE" modified="2021-09-29" version="1">MPCHVLEIIYISHEIFPRWNLLSVFLKQNILYFLFYVRSFTHNFFLSFFLFFLSFFLYFSFFVPFFLFNSVLYFLYFPSSEVSIVSNSCLYLNFFLPFFLSFFLSFFLEDLLLFFYFSFYLAFFCFKFLLFFNHFSYLLISLLLSFSYIIFSFYLSPWLHFASALVLGFLFFRHIYFVPLNSFLFLHFFPFFIVLNFSFLSFFLSFFLSFFLSFFLSFFLSLLLPSCLILQICRNPVFFLSFSPSLSIFSLSLCFFLSFCISFFLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BI88</accession>
    <name>A0A812BI88_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_16535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000583">
        <property type="protein sequence ID" value="CAE1227788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BI88"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1227788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="262" mass="30962" checksum="FCC6EE8817AE9514" modified="2021-09-29" version="1">MHLSIYLSIYLSIYLSIDFGMLLCMYVCIYLSIYLSVCLSIVFCFFIFYLSIYLTIYLSMSTTNSSYISHTFSNVVSIYLSICLSVYRILFLYFSIYLSIYLSIYRISIYLCIYLSVCLSVVFCFFIFLSIYLSIYLSIYLSIDYLSIYLSICLSVCRILFLYLSIYLSIYLSIYLSNVVSIYLSIYLSIYLSIYLSIYLSIYLSIYLIQLNVHLCVFDYLPACTFIYLSIYLSIYLSIYLSIYRIELMSYATNLIRHDYVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BIA3</accession>
    <name>A0A812BIA3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_17158</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000609">
        <property type="protein sequence ID" value="CAE1229141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BIA3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1229141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="151" mass="18527" checksum="7B02905150DE27B1" modified="2021-09-29" version="1">MFYPCSLSLIHFLFLSFFLSFFIYRYLFFRSFFFFASFFLSFFLSFFLSFFLSPLQVPTSIFLSFFFSHFFNAFSFFVPSFFFTPFSFFLSFFPSFFPSFFLSFFLSFFLSFFPSFLPSFFLSFFLSFTSTTFFVFFFLSFYLLSFFFLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BIN5</accession>
    <name>A0A812BIN5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_17507</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000624">
        <property type="protein sequence ID" value="CAE1229850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BIN5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1229850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="217" mass="24302" checksum="12BE6E9946988AE5" modified="2021-09-29" version="1">MMFFVVRSALRACNCDSLSLSLSLSLSLSLSLSLSLSILIDSGFNFSACLYLHHLFVIFLTFPLSISFRSISHSLYNTKVENLSIYLSIYLSIYLSIYLSIYLSIYLIKMIQISSAHFHSCFHHYAFSIPLMRNIWASGVSLSLSLSLSLSLSLSHTQRNEQILIAYIPETDPSHQDNHPLTTFPDSLYCISLSLSLSLSLSLSLSLSLSISIFLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BJ43</accession>
    <name>A0A812BJ43_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_21313</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000780">
        <property type="protein sequence ID" value="CAE1238403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BJ43"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1238403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="293" mass="34870" checksum="5A49B80EF2F18B35" modified="2021-09-29" version="1">MLVSLLFFLSFFLSFFLSFFLSRNEYAIFFLSFFLSFFPWDMLINIYLSIYLSIYLSIYLSIYLSIYLSHSVSIYLSIYLSIYLSIYLSISFCFYLSIYLSIYLSIYLSIYLSLLDVHTDILIVSIYLSIYLSIYLSIYLRLIISFFLSFICPHCYLSLYLSMFNYFCFTVKSIYLRWMYMSKGISKFDLLFRSILLNRSIYYYNFGKKPGFTVLNLKEGRALPACKITKQFSFSPILEKVWIGLSIYLSIYLSHPVSIYLSIYLSIYLSIYLSIYLSFVFTIKAFFSVRFCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BJ51</accession>
    <name>A0A812BJ51_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CERK</fullName>
            <ecNumber evidence="3">2.7.1.138</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_17751</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.138" evidence="3"/>
    <dbReference type="EMBL" id="CAHIKZ030000634">
        <property type="protein sequence ID" value="CAE1230429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BJ51"/>
    <dbReference type="OrthoDB" id="530923at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001729">
        <property type="term" value="F:ceramide kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006672">
        <property type="term" value="P:ceramide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050187">
        <property type="entry name" value="Lipid_Phosphate_FormReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358:SF111">
        <property type="entry name" value="CERAMIDE KINASE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358">
        <property type="entry name" value="SPHINGOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032355927" evidence="1">
        <location>
            <begin position="26"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="DAGKc" evidence="2">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1230429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="270" mass="30270" checksum="37274972D067A339" modified="2021-09-29" version="1">MFIGTLLLQPLTFLFFLSRIISVGGDGMYSEVMNGLVLRTQKDAGVDHNTPEARMQPCDIPIGIIPAGSGDVLCMFLYGTRDPETCALHIIKGFQRSTNIYSVHYGHKLACYCGLILGFGFSGYLMRSSNKHRWIGPARYTVMILVYMLKHAFFKMNVRYLAVNQNGGREESRTNGNCTSNVDEVKWTSLMGDFHSIDTWAVTLARNGEFLQPLFGDTTSTVIMLNKCGRLEHLKYLEQLSKLKSVCVSHCAPSSTSFFFSFLIFSSSFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BPW6</accession>
    <name>A0A812BPW6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_20634</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000758">
        <property type="protein sequence ID" value="CAE1237226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BPW6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1237226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="222" mass="25815" checksum="358574CA44F7E599" modified="2021-09-29" version="1">MTCFSLFFYSFSFFHSSVIYFFFSIFFSFFSFFVPLPSNFNLVFYFLSVLFYSLPILNFSSPSSLNFTSILFPFSSSSSFCVAFDPPSLPLFLFFLFYFAFLFLHFSLSFFSNLPLFIHSSSPFSFSFLYFSLFSLKSPLLLPHSFIHFPLTLSLLLPHINFHSFILSFSLCFYPYIGSLTLFSTSYYPHFLIHSPFSNPTYILDVLLLLPIFSTQSNTING</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BQP1</accession>
    <name>A0A812BQP1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_21839</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000802">
        <property type="protein sequence ID" value="CAE1239406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BQP1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1239406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="175" mass="21248" checksum="63D6B16FA3ACE026" modified="2021-09-29" version="1">MHATTFFFNFPKHNIGYLSIYLSIYLSVLFQSHSIYLSIFSFPVFFFLSFFLSFFLSIYLSIYLSIYLCISFLFSPLRRPIYFFIFRSFSIYLFFFNPFPSIYFFLFYLCMYLCMYVCMYVCMYLSIYLSIYLSVLFSISFYLFFFFGLFLSIYLSIYLSIFFIIPRVPTFSIAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BT08</accession>
    <name>A0A812BT08_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_21207</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000779">
        <property type="protein sequence ID" value="CAE1238241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BT08"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
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            <begin position="7"/>
            <end position="25"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="50"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="79"/>
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    </feature>
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            <begin position="85"/>
            <end position="112"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1238241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="231" mass="26541" checksum="EF3026C5309584EB" modified="2021-09-29" version="1">MHSLPSIFYLLFFFVLFFYNLSFLLLLLLLLLLLLLLLLLLLLPILALLFSNIVDIAIGFVVSLHIFLFQLFSYLFIYLYRSLHIYLSIYLSIYLSIYLSIYFSPFISIYLFHCLHTSLFISFSSYHIIYLLISVCSSIYLSIYLSVYLSIYLSIYLSICLNLFILSIYLSVMEATGLESCGSTPLREVSEHESCSSYSFLPPSLSLSRSPSPSLPLSPSLSLSGMRNYLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BUS4</accession>
    <name>A0A812BUS4_ACAPH</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_24399</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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            <taxon>Spiralia</taxon>
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            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000910">
        <property type="protein sequence ID" value="CAE1244686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BUS4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1244686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="287" mass="32517" checksum="CA65CE0CC1812241" modified="2021-09-29" version="1">MYNLLFVHVCFVSVCLSVLLSVSDCSSLFVFPSVLVSLSVFPSVLVSLSVFASVLVSLSVFASVLVSLSVFASVLVSLSVFASVLVSLSWSLFVCLCFCLGLFVCLSFCLGLFVCLSFCLGLFVCLSFCLGLFVCLSFCLGLFVCLSFCLGLFVCLSFCLTLFMSVRLSAIFKLIKFSDNICISFFSFFLLFLSFSFFSLSFLLFLFSSLSLLFFSFFSLFFLLLFSLSFSSLSLFFLFFFSSLLLLFSFYSFFFLLFFFFFFFFYSLFFFFLLIFLLLPPETKQHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C146</accession>
    <name>A0A812C146_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ECHDC1</fullName>
            <ecNumber evidence="1">4.1.1.-</ecNumber>
            <ecNumber evidence="1">4.1.1.94</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_29323</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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            <taxon>Spiralia</taxon>
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            <taxon>Mollusca</taxon>
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            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
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            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.-" evidence="1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:methyl/ethyl malonyl-CoA decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1255084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="154" mass="17763" checksum="947512373E6BD7FC" modified="2021-09-29" version="1">MDKESGIAKITLNHPEKKNALSGKMIVDLVEIISELEKWKSGKGLFLHGTSHTFCSGVSFFRSVSHFQFWKIPHHFWEEPLYDISLHDLSFFLSLFHTSNFGRSPLLREEPLYDVSLPDVSLNCSFCLHNYKFLSQEILVNNFPSTLIPFNSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C300</accession>
    <name>A0A812C300_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_28477</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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            <taxon>Mollusca</taxon>
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            <taxon>Coleoidea</taxon>
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            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="CAE1253525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        </location>
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        <location>
            <begin position="875"/>
            <end position="894"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1253525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="908" mass="109010" checksum="94CE95FA3FF116FA" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C365</accession>
    <name>A0A812C365_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_26342</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001004">
        <property type="protein sequence ID" value="CAE1248778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C365"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="31"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1248778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="265" mass="32570" checksum="F9778EB9B2828A1E" modified="2021-09-29" version="1">MIFFSVLIFLSFLFFVNICLSSFPFSLIFSFYFSLFSSLSVFLYYFLSFFLSSFLFIFFINIFLLFSLTLFPLLPLFLEYFHNFFLFSFSLIVFFFLLSLLFSFSLIFSSFFLNIFFLYFLIFCTFCFNIFLVTFLSLLFFLNFFFLFFSFFLNIFFLSFFLFFLNILFLLNIFFFPLFQFFSLIFSFFISFLFFRFSHNFSILLSFRFSFIFSFFFSFFISSSSAFSLIYSFFLSFFLSLLFFLHIFFRFSLIFSFFPFPIFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C581</accession>
    <name>A0A812C581_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">CYP3A</fullName>
            <ecNumber evidence="10">1.14.14.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SPHA_30286</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Farmed</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.1" evidence="10"/>
    <dbReference type="EMBL" id="CAHIKZ030001216">
        <property type="protein sequence ID" value="CAE1256603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C581"/>
    <dbReference type="SMR" id="A0A812C581"/>
    <dbReference type="OrthoDB" id="6507799at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008395">
        <property type="term" value="F:steroid hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11055">
        <property type="entry name" value="CYP3A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050705">
        <property type="entry name" value="Cytochrome_P450_3A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24302">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24302:SF15">
        <property type="entry name" value="FATTY-ACID PEROXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="258"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="339"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="485"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00043906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAE1256603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="539" mass="62755" checksum="A6B3EAFC01657C0B" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C6Q0</accession>
    <name>A0A812C6Q0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_28690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001125">
        <property type="protein sequence ID" value="CAE1253936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C6Q0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1253936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="206" mass="23374" checksum="AC2B5C4EC27E5DB1" modified="2021-09-29" version="1">MSQLYSFQGCRRSFQQLNGNAQRRLHVPALFLQGCRRFLSANQIIMLRRLNVPAFILQGCRRFFSNQNVNASETTSCPSFYSLAVEDYFQQPKAGNASETTSCPSFIPLQGCRRFLSAKLNGNASETTLCPQLLFLQGCRRFLFSNQIIMLSETTSCPAFSFKVVEDSFQQPNGNASETTFMSQLLFLHIVEDSFSNQMVRRLSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C7Q7</accession>
    <name>A0A812C7Q7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_31050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001260">
        <property type="protein sequence ID" value="CAE1258065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C7Q7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1258065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="163" mass="17622" checksum="8C4A2F470B20D737" modified="2021-09-29" version="1">MYAIHLSHKMRKVPLPLSPFPPLSLSLSLSLSSHSLSLSLSLSSITLSEKEVNLVQILFLFLLTITDYELVNVYFVFNLLAFSPSFHLSLSLSLSLSLSLSPPFACITSFLSLIPSLSSFSLSLSLSLSLSPPLPALLALSLIPSLSLSLSLSLSLSLLCLHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CAK4</accession>
    <name>A0A812CAK4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_31348</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001285">
        <property type="protein sequence ID" value="CAE1258729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CAK4"/>
    <dbReference type="OrthoDB" id="10261634at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1258729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="195" mass="22276" checksum="F74155D6CA8DB884" modified="2021-09-29" version="1">MNPIAESHHCMNPHAESLHCMNPIADFFHCMNTNAECLHCMNPIADFFHCMNPIAECLHCMNPTAHFFHCMNPIAESLHCMNPTAESLHCMNPTAESHHCMNPHAESLHCMYPTTDFFHCMNPIAESHHWMNPHAESLHCMNPIAESHHCMNTNAECLHCMNPIADFFHCMNPKAESHHCMNPHAEYLHCMNPNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CAM5</accession>
    <name>A0A812CAM5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_31363</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001286">
        <property type="protein sequence ID" value="CAE1258755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CAM5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="313"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="344"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="375"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="403"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="428"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="455"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="484"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1258755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="507" mass="65290" checksum="299BB695342C24AD" modified="2021-09-29" version="1">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</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CC18</accession>
    <name>A0A812CC18_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_32396</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001347">
        <property type="protein sequence ID" value="CAE1260779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CC18"/>
    <dbReference type="OrthoDB" id="6127549at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF6">
        <property type="entry name" value="DOUBLECORTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1260779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="455" mass="52152" checksum="54ED2F06D247394A" modified="2021-09-29" version="1">MVGLNVETNFSLIGQGAQTDLPKQPPPIISYHSPNSRVEDTEPPNDRYPTNTRDASQSQYTSDLVRYFTWQELITTGLPPFNDRPEDYRVWKRSFQNAIRHLGLAYREEMDLLVKRLDLLDFVSHNGKLAERRLSSLRRRLDKKPEMQRHFLSFMEGLFENGHAEAAPPLRKEEECWVFTSFRKEIVAITADIKQMFHCFSVKEEHRNFLRFLWYRDNDPTKGIAEYSMKVHVFVNSPSPAVAIYCLRQAVRKGQPNYNPAVEELVNQNFYIDDCLKSLPTIEATVSLLQRTRDILARSNLRLHKIASNKGVMTTIPPQDHANNLMNLDLSKDELPIQRSLGLEWHLKTNTFTFKLCKRKSILKNSSIANKEELPKGSTLKGLNPFIDSHSLLRIGGHAGKAEIETRKKHPIVIPGKHHIGSLATTMDKPDIRDACSLRELSVLQDFGWLAGRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CC73</accession>
    <name>A0A812CC73_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heme-copper oxidase subunit III family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_32477</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001355">
        <property type="protein sequence ID" value="CAE1260965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CC73"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000298">
        <property type="entry name" value="Cyt_c_oxidase-like_su3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50253">
        <property type="entry name" value="COX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="309"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="337"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="366"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="391"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="416"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="448"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Heme-copper oxidase subunit III family profile" evidence="2">
        <location>
            <begin position="126"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1260965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="470" mass="58782" checksum="D51FBA6F479AA128" modified="2021-09-29" version="1">MPFAAIDREQFPPTRLSCRLWDLVVPSKHLLFTFPFFRRPSTALPKQKNQKNRRVSDPAEIYKLSRNRLFFFFFFFFFFFFFFFFSFSFLLSLFFLFLFSFFSFSFFFLLFFFFLFFLFSFFLFSFSLSFFLLFLFSFSLLFSLLFFLSLFFFSFFFFSFFLSFLFSFFFFFFLFSSLFLKFFSSFFSSLFLLFFFSFSLLFLFSFFFSFLLFFFLFFFSLSLLFFLLFFLFFFSSFFSSLFLFSFFFFFSSLFLSSLFLFSFSFLFFSFFFSSFSLFFSSLFFFFLSLFFSFLLFFLFFFFSLFFSSFFFFSFFFFFLFFSLLFFLFFFFLFSLLFFSLLFFSSLFFFSFFFLFSFFLFSFFSSFFFFFFSSLFSLFFLLFFFFFSSFFFLFSLSFFFSLFLFSFFSFSLFFSSLFLFFFFSSLFLFLFSLLFFSSLFFFFSFSFLFLFSFSLLFFLFSFFSSLFSLFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CCA9</accession>
    <name>A0A812CCA9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_30903</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001247">
        <property type="protein sequence ID" value="CAE1257625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CCA9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="359"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="396"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1257625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="421" mass="49480" checksum="1841021326DD5575" modified="2021-09-29" version="1">MFLFSFFPFSLLFFAFLFFFVVLSVFLSLSLSLSFFFLIFVFHPFCLFYFLCFLLYFLSFFLSFSFYRFILSFIYPLFIHFFYIFLSTFFLWLPSCPPSFLLSFFLFFLSFFLSFFLPNFRDYLSIYLSISVNYSLSIYLFTYLSACLSDWFVSIDLLNAVHIYLSISYFCSYLSIYLSIYLSIYLSIAICSDLSILVSLYLSIYLSNDLFLSIYLSIYLSIYLSIYLSLCRFLNLSIYLSIYLSIYLSIYLSIYLYTSVLLYVSNFISLLYLSFYIPFTIIFPLLGLIYSYFAIDQFIDLSLPLLSLSLLPFIYFASFSLSRLALTLPLSVTSYFFFLFFLSFFSFFLFFLSLSSPSLSLSLSTVTLFDPFHLFLSHFPFSLSPASLRLPLLLSLSLSLSLSLSLSLYLSIYLSILFIHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CF16</accession>
    <name>A0A812CF16_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_34826</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001488">
        <property type="protein sequence ID" value="CAE1265736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CF16"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1265736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="159" mass="18530" checksum="AEBB515F1FC8D7D7" modified="2021-09-29" version="1">MLFPFNSLLRDCLIHFTCSFLEKALIPLLRDCLIHFTCSFLEKSFNSPLLRDSLIPLLRDCLIHFTYSFLEALIPLLRDCLIHFTYSFLENSLLRKLEFLSFVTVSFILHALFLEKALIPLLRDCLIHFTCSFPGEKALIPLIRDCLIHFTCSFPGERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CF22</accession>
    <name>A0A812CF22_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_32312</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001340">
        <property type="protein sequence ID" value="CAE1260639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CF22"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1260639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="154" mass="17633" checksum="99520EB88D8F2F12" modified="2021-09-29" version="1">MHLAVDVQQTELTSPTESKLCNLHWCQHHTHSNLRLLYLPLFFSISVSFSLSLSLSLSLFSLSLLEKNIERERTSFQKLFILLSHTLTDSISLSLSLSLAEKEKVFRNPLIFYFTQPLSLSLSLSLSLSLSLSVSLPEKDGESFQKFFTLLYRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CFE2</accession>
    <name>A0A812CFE2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_32564</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001358">
        <property type="protein sequence ID" value="CAE1261052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CFE2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1261052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="299" mass="34465" checksum="B239B741ADF5E74C" modified="2021-09-29" version="1">MDDEMREEITNLTLITTFPDINPTELVYPIEAGENDFWLLFATLVFFAHLLVTWFLSLLPSFLPSFLPFLPSFLISFLPLFFLPSFLPFYFLPSFLVLYVLPSSLLSLLLSFHPYFHLHFPFPLHAFVHSFFFPSLVPSSHLSFFPSSHLPLVPLFSTLSFPSILPFFADFFPTFFSSTLHSFVHSFFPPFFASFFLPSFLHSFLPSSLSLLYFLPSSLSLLYFLPSSLSSLLPSSFLSVLLIFFPFSLLSSFFSIFLLPSFIPPSFLLLSLQPFLPPLSFIFFLPSSLFLFFYHSFLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CGA3</accession>
    <name>A0A812CGA3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_33669</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001413">
        <property type="protein sequence ID" value="CAE1263279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CGA3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="358"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="391"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="419"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="452"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="493"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="552"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="579"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1263279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="606" mass="72357" checksum="A5E1FA745CA35728" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CGN1</accession>
    <name>A0A812CGN1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_33248</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001391">
        <property type="protein sequence ID" value="CAE1262466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CGN1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1262466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="247" mass="29282" checksum="7771A7C7B82320D5" modified="2021-09-29" version="1">MLLLQRFTDGSSRSTPRSSRSVQRLNICINLDISFFSFLSFFLSFFLSFFLNVSLISFLSFLFFPSFFLSFFLFLLSSYLSPLRSSFLSFFLSFFALIISFFFLSFFLSFFLSFFLSFSRSEIFFLSFFLSFFLSFFLSPLRSSFLSFFLSFFLCFNHLLLSFFSFFLSFFLSVIPFLSRQMFTKSRSEILFVCLFVCLFVCLFVSFFLSFSFAFIISFFLSFFALIISFFLSFFLSFFLSVIPFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CH15</accession>
    <name>A0A812CH15_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_35148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001510">
        <property type="protein sequence ID" value="CAE1266345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CH15"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1266345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="257" mass="30993" checksum="3CCAAFCF929DBBA7" modified="2021-09-29" version="1">MTVDCKLFISIYFLFLSFIFLLFLYISFFLFPLSLSSAAYQINFLLRSFFFSFFLCISKQFLLFFVVFSLFISKSFLSFFLSFFLSFFSEDLSFLFTLQVFFFFSFFFSLSFYFLSFFLSFFLSFFLSFFIYLFISIHFLCFFISLYISITHTLSLSLSLSLSLSIYFISSFNHLSIYLSIYLSIYLSIYLSHQRPIQLTLLSFFSSFFHYFFLFPFFLYFYSFPLYLSFYYTHSLSISSAVYPINSPLFLFFFLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CH75</accession>
    <name>A0A812CH75_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="18">MMP14</fullName>
            <ecNumber evidence="18">3.4.24.80</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">SPHA_35198</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">Farmed</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="12">Can bind about 5 Ca(2+) ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M10A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.80" evidence="18"/>
    <dbReference type="EMBL" id="CAHIKZ030001512">
        <property type="protein sequence ID" value="CAE1266505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CH75"/>
    <dbReference type="OrthoDB" id="1901267at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030574">
        <property type="term" value="P:collagen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00094">
        <property type="entry name" value="HX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04278">
        <property type="entry name" value="ZnMc_MMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.110.10.10">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000585">
        <property type="entry name" value="Hemopexin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036375">
        <property type="entry name" value="Hemopexin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018487">
        <property type="entry name" value="Hemopexin-like_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018486">
        <property type="entry name" value="Hemopexin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033739">
        <property type="entry name" value="M10A_MMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001818">
        <property type="entry name" value="Pept_M10_metallopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021190">
        <property type="entry name" value="Pept_M10A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201">
        <property type="entry name" value="MATRIX METALLOPROTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201:SF291">
        <property type="entry name" value="MATRIX METALLOPROTEINASE 1, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00045">
        <property type="entry name" value="Hemopexin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00413">
        <property type="entry name" value="Peptidase_M10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00138">
        <property type="entry name" value="MATRIXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00120">
        <property type="entry name" value="HX"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50923">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="PGBD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00024">
        <property type="entry name" value="HEMOPEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51642">
        <property type="entry name" value="HEMOPEXIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0106">Calcium</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="10" id="KW-0865">Zymogen</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="163"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="303"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase metallopeptidase" evidence="17">
        <location>
            <begin position="324"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="14">
        <location>
            <begin position="596"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="14">
        <location>
            <begin position="640"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="14">
        <location>
            <begin position="688"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="478"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="490"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="521"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="370"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="380"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="382"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="387"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="388"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="395"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="409"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="411"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="412"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="414"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="414"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="431"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="435"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="441"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="557"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="559"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>5</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="602"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>5</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="646"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>5</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="692"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="modified residue" description="Phosphotyrosine; by PKDCC" evidence="13">
        <location>
            <position position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR621190-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR621190-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CAE1266505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="735" mass="83827" checksum="84CA16670165CAD5" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CHX9</accession>
    <name>A0A812CHX9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_35011</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001502">
        <property type="protein sequence ID" value="CAE1266105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CHX9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032770937" evidence="2">
        <location>
            <begin position="20"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1266105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="236" mass="27969" checksum="A7865270263F7775" modified="2021-09-29" version="1">MSLSLFLLLPLPPPPPSSSSSNFLFLCFLTFPSCLYPYFFYFLILLLFFFFFFFFFFFFFFFSLSFFVYLAFCHNFFHISLSLSSPPLFLFSLFVSPFHPSIFTYLSYVRYLDFLSISPFKYFSTCYFIFFFFHSILYLVFIHFITFSLTPFRHFFLLCISFLNTRYYFFSLFSPSETTSNPVYYNLFFRSSSALHSQPPPLRSPSIVLPNRYLTGVRPLPARSPFAFIAVIADAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CIF5</accession>
    <name>A0A812CIF5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TFG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_34799</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001486">
        <property type="protein sequence ID" value="CAE1265657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CIF5"/>
    <dbReference type="OrthoDB" id="1594986at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048208">
        <property type="term" value="P:COPII vesicle coating"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06401">
        <property type="entry name" value="PB1_TFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034857">
        <property type="entry name" value="PB1_TFG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033512">
        <property type="entry name" value="TFG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15335">
        <property type="entry name" value="PROTEIN TFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15335:SF7">
        <property type="entry name" value="PROTEIN TFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00666">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="348"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="PB1" evidence="2">
        <location>
            <begin position="28"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1265657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="373" mass="44554" checksum="B09E980389E57529" modified="2021-09-29" version="1">MPVGVFVNVKKKPVIMNSYDGQMDLSGKLIIKVQLGDDMKFIPIHNVDITYDELVLMMQRVYRGKLGTNDDIIIKYKDEDGDLITIFDSSDLSFAIQCSRILKLTLFVNRTTNNLDHDEVKYIRHELTHLNDRISHLLEDLQHPAIESELVDEVVGNSSFSFFLFCFSFSFLFVFPYFLLPFFPFFLLFSFLFFFPSFSSFSFFFRFFFFLFLFYFLFLFLFYFCFSFFLSFCFSFLSLFAFPFFLSFFFFLFLSLSSFFLSFSLSLSSFFLFLSLFLLSFFFSLSFFFLSFSLSLSSFFLFLSLFFLSFFLSLFLLSFFFSLSFFLSFFFSLSFFFLSFFFSLSFFFLSFFFSLSFFFLFLLLSFNQTDARD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CIG8</accession>
    <name>A0A812CIG8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_36322</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001588">
        <property type="protein sequence ID" value="CAE1268923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CIG8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="325"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="360"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="390"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="433"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1268923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="456" mass="51598" checksum="6713B4F1417CB13C" modified="2021-09-29" version="1">MRTNEQNTGDNNFNLPTSVTSKQSYLLTTLINNSTSLPPYNIFSACFILSLILTLTISLLSLILTISFILSFTLTFTISFILSLILTLTISFICSLTLTISFIFSLTLTHTISFILSHLLYILFSLSLYLLFSLLFSLYLLFSLSHSHSHYIFYSLSLILTISFTFSLTLTISFILSLILTLTISFIFSLTLTISFILSLILTLTISFMFSLILTLTISFILSLILTISFILSLTLTISFIISLILTISFILSLILTLTISFILSLILTLTISFILSLTLTISLFSLSLYILFSLSFSLYLLFLTLTFILSLSLTLTISFILSLILTFTISFILSLSLTLTLTQYIFLLNNEKSNTNLSAIIQLILFQAIDLSIRFLYRQQISNPIPDNFCILFFFSNLLCDYATTLSQRFLLSSFFSSSFLIRLLLHPSPSFFLFFPSFSFSFFLLLLSPSVFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CK65</accession>
    <name>A0A812CK65_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_39032</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001800">
        <property type="protein sequence ID" value="CAE1274721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CK65"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1274721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="273" mass="30285" checksum="A00E5073422F36FA" modified="2021-09-29" version="1">MFPLISFPPSSTSISVSLLSAYLSSSFSLPFSLPISLSLTFLFNFSSLLPINASVILSKCSLSASHFPARDAIILFSLFLLFSLPITLNFPFFLHTSFPLYLFLFPSFSLPLLPINASVILSKVFHFSSPLTSPLFLYFLSFYRPLFEIFSLFLSLFSLFLSPLSLSLSLSLSLLNLLSISSISRSFSFYFSKSLSLLSLYLFFLSYSFFSLSLSPLFLSSFSLSLSISSDFFLAKYSSLSLLQISLYLSSLFLSSLSLSISLSSLSLSLSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CR05</accession>
    <name>A0A812CR05_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_41831</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002022">
        <property type="protein sequence ID" value="CAE1279524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CR05"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1279524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="168" mass="18948" checksum="EBE05906E4F9BC26" modified="2021-09-29" version="1">MHVQCKPVPLSAALSSQPPAGESSATAGISGERQFARSMVPLFPYLYIYLAMSIYLSMPISLPIYLSIYLSIYLYAFISIYRSNEQFLSTYLYLIMLLSIYLSISLCSHLSQSVLVHLSHSYASIFPIYLSHSVLICLFISFFSYLSIYLSVCLSIYLSIYLFISVCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CRJ7</accession>
    <name>A0A812CRJ7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_38735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001774">
        <property type="protein sequence ID" value="CAE1274265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CRJ7"/>
    <dbReference type="OrthoDB" id="6071124at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1274265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="375" mass="42372" checksum="664A13FB19FC4142" modified="2021-09-29" version="1">MPVHYFLSIYLSIYLSIYLSIFMSYCKKKGFVRLFIAFWLFICSGILLVGAEIQCYQCTSTFLDTNGKPIAGKENPNCPVDGTVKPDATYSESCSEKCLMRTGLRNAGVVIRSCSAQIPLPQPLPENGCYSHQGDIHCLCNTSYCNGQAMNELLRNRTLKDLKSLARAASEEYEKNNKGNAGDKKDGPHQCYICQSSYQGKMNENCPGDHHINAGPTIYRSNCSGPCYRKTFLSFFGQSCQHHCFHSFFFYSSVYSYLFSITRSFFLSYLFYLSIYLSIYLSNYLSNKNLSAYIVYRFPKPTPKDGCYKYYVDVWCICRGHLCNTKPLGKAQNKELDYMVDIKSKGSRHLTMMSLVLMTAGAAILSTESTSIDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CTK0</accession>
    <name>A0A812CTK0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_40751</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001935">
        <property type="protein sequence ID" value="CAE1277627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CTK0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1277627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="191" mass="22487" checksum="CD78A5D4451A3E8B" modified="2021-09-29" version="1">MLLLFDCSPLEPPHCKECRASCHNCRQETMALPRVTIRHNQPTYLSIYLSIYPSLFISIYLSQSVHIYLSIYLSMLGPLSSYLSSYLSQFLSIYPSFFLSICPGFFFFLSFFLSFFLSFFLSIYLIRHYLSYPILSYSILSYLSIYLSIYLSIYLFESVNIYLSIYLCSGFHLVNVVWKRRDIVNKTCRPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CTS9</accession>
    <name>A0A812CTS9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_41952</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002024">
        <property type="protein sequence ID" value="CAE1279649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CTS9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1279649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="250" mass="29176" checksum="000A8E42CB32E48F" modified="2021-09-29" version="1">MLEIYLSIYLSIYLSIYPCLSIYSSIIYLSIYLSIYLYQSLHLLSHSIYLSIYPCLLIIHPSIYLSIHLSIYLSQSLHLLTIYLSIYLSIYLSIHLSIYLSIYLYQSLHSLSHFIYLSIYLSIHHLSIPVCSYLSIYLSIYLSIYISLHSLNNSSIYLSIYLSIYLSLSAPIYLSIYLSIYLSIYLSIYISLFILSHSIDLSIYLSLSAPIYLSIYLYQSLHSLTLYLSIYLSLISRIPFLLYVIDFINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CY93</accession>
    <name>A0A812CY93_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_45962</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002401">
        <property type="protein sequence ID" value="CAE1286376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CY93"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1286376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="153" mass="18987" checksum="091ACD3CBEC213CA" modified="2021-09-29" version="1">MTSSIFHLFLIFFLFLSFSFLSFSLFRLFLFLSFSFFLHSFFFFSTYIFSVFISFFFFLFLSFSFPLFLRFFPNLYFSLSFLLLYFFLPFFFSFHFFFCFLPCIFSFSFFISICCIILFLLHLPLSFILNYFFSTWFLTILYFFLSFFLSFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D287</accession>
    <name>A0A812D287_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_45306</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002334">
        <property type="protein sequence ID" value="CAE1285228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D287"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="778"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="817"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="855"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="887"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="913"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="952"/>
            <end position="973"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1292304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1110" mass="123322" checksum="3CE53F07A4ECAE2E" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D991</accession>
    <name>A0A812D991_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_52071</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003208">
        <property type="protein sequence ID" value="CAE1297560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D991"/>
    <dbReference type="OrthoDB" id="6144264at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1297560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="305" mass="34440" checksum="0B221FE5BE69D406" modified="2021-09-29" version="1">MGPTEQHKVFSGHGSSYQRYTPKEQQDRKATPYKLQAANGSTIETYGAKTLTLNIGMRRDFTWTFTQADVKTPILGADFLAHYDLAVHMNTRTLSDNTTNIAVKGTLSRHNTTGISVTTCHGREYIEILNRYSDLIQPLAGTGPARHQTQHHIKTSGQPTFSHPRRLPPHKLEYAQKETTNYQAAILHDSPPKDELTTPQHCPRRSSLSASADAPFTQVQTSRDRLDLGHPCFHSAYLQAVALKPDNAPSRLHDRTTTNDYLYIFVPDLFNKIWLKLLHPRFCCPCFDRITLYYFSVCGVNSQPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DAX7</accession>
    <name>A0A812DAX7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_49005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002777">
        <property type="protein sequence ID" value="CAE1291982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DAX7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="337"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1291982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="460" mass="53166" checksum="C23ABA4E75848606" modified="2021-09-29" version="1">MKVQHPSTPYSEEYSVLCFFFFSSIYFFAHYSFPQRLSSPSLHRLRLPSAFLLSNYSIPVSSPLPSNHVFSSYFHCLPFFFILILAVLHLLFIPQFSLPAFQYFSESSSTLSFLPFHTSSSTLSLSSTTTHSISLSLSLSLSLSLSLSFSISFHGCSYTLPLTSPPIYFHRVCSDLVVLAPLFLFSLPFFPSDSFFLHFPLSSVLWLILHLCLPFPFSSFNSFSSSSILFSPFLFFLPSIFSPSSFSSFFFSFDCFPSSFFLLFRFFLFLFYSILSPPLLSHSLNSFPFSSLSSFYSFNSTSFFLFFIFSFLFLSLFSIFLLSFLFSFQFFSSFFFVFFRIIPSLFLSRLSILSLLLYFSSLSFSSFCFHSFYFSILTIFSLTSFLSLRIFPLHFLSRHSFLSSLLFFFQYLFFSQLFFIPLPFTSLLSFSFSFNSYISSPFHNITHVFPTFSICICNPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DBE7</accession>
    <name>A0A812DBE7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_49864</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002895">
        <property type="protein sequence ID" value="CAE1293527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DBE7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="287"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="318"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1293527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="338" mass="41133" checksum="3707CCC10BCC29D2" modified="2021-09-29" version="1">MFFGHVIFFIIYLSIYLSIYLSIYLSISIYIYLFFCHFFGPVFIFVIFYILFLFSFSLFSVDNSSFFLSFLVLSFFSFLCPSFNSFFLSYSIFFSFFLSFFLSFFLFSILHHSINFLSSIFVSLFIIRYYFFLFFFLSFSFHPLSFFLSFIYIRSPLSFFLSFFPSFFLSFFFFFLFPQKLSCTFFLFFFCRFKGFSFNLYFLIHIFLSFFFKFVHSFFFSLSISPAFLQSFFPTPYFSFLFLCHYTVFVSFSLFTLFLLFFFLSFFLSFFLSFFLSFSFHLLSSSFYHLFLSFFLSFFLSFFLSFFLSFLFCTFLSSFFIILSFSFLSLFFLSFLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DDE5</accession>
    <name>A0A812DDE5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_53851</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003443">
        <property type="protein sequence ID" value="CAE1300424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DDE5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1300424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="288" mass="32251" checksum="1A979DF3208A8546" modified="2021-09-29" version="1">MSIVIFSLLNFLFFYCSLSLPLSFPLSLFLPLSLPLSFPLSLSSLFPSLFPSLSLPLYFLPLSLSLSHSLSLSLSLSLFPSLSLSLSLSFSPPLSLSPSLPLSPPLPLPLYLSLPLSFPLPLSFPLPLSPPSPPSLSPSSPPSLSLSLSLFLSDLNVFFFLYSFTLMPVIIFIYLSIYLSIYLSIYLSKFISKFIPIYLSIKFISKFGLFYHIYFLLSINIFYLSIYLCQYIGLIFIAGNIFYLSIYLSIYLSIYLCSGQKSFGQAISSYLDNVKCQTTRGYRIIDKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DIP9</accession>
    <name>A0A812DIP9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_57480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003879">
        <property type="protein sequence ID" value="CAE1304976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DIP9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1304976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="342" mass="40542" checksum="F41E81E455B74474" modified="2021-09-29" version="1">MLATLVLNSKLVHFFLLLSLSLSLSRPLLYRLYFFLPFKSSILSSSPIQHAPAVDSCFIFSFPFVRLSDISFFVYLYLFLSFFSPHFLFFLSFFELFSFSHSFYLFDCLLLLSLFFFHYSLSLNNLFFFYSFFLSFSFNNFFHSFNTLLLSFFFFFLSAHLSFFLSFFLFLSFFLFLLSFSTPFFLSFSSFFLSFFLFLLSFSTSFFLSYFPFFFFLSFFLVHLHIERFPLFLSFLLTFFLSFFLSFFLVHLYIERFPLFLSFFLSFFFSFFIIILLLEYLEIRSLSLSLSLPLSLPSLSLSLSLSLSTSEIYYSVINCSTITPRRSAPTSQDVLGRSVTIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DKK9</accession>
    <name>A0A812DKK9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_58433</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003993">
        <property type="protein sequence ID" value="CAE1306132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DKK9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24216:SF65">
        <property type="entry name" value="PAXILLIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24216">
        <property type="entry name" value="PAXILLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="143"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="305"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="342"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="549"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="588"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="623"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="664"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="688"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="730"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="758"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="789"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="820"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="450"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="515"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="389"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1306132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="839" mass="96404" checksum="D7A48071F0E82F26" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DKS5</accession>
    <name>A0A812DKS5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_54977</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003632">
        <property type="protein sequence ID" value="CAE1302368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DKS5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1302368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="164" mass="18353" checksum="8F54031BF18F2B26" modified="2021-09-29" version="1">MSQYLVPSLHIYTPGQVLGTLHFQPPLGTSGLTPSPFPVRLPITRGRSAFFSNACQHVAIVCCSYQSVLTVVFLHLSIYLSIYLSIYLSIYLSVLGCSYQSVLTVVFLHLSIYLSIYLSIYLSILACSYQSVHIIVFSHLSIYLSIYLSIYLSIYLSMYLSILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DKY7</accession>
    <name>A0A812DKY7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_57932</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003927">
        <property type="protein sequence ID" value="CAE1305509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DKY7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1305509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="287" mass="34823" checksum="1D2DC7B0451F06C8" modified="2021-09-29" version="1">MFHILFLCNFSFLLFSFLIFHFFIVHLHYFINSVFVFFLLFFVLLSYTFSFFLTSFFLTLTLHFSSFLLFNQTFFLSFITFIFLPPLSFFIFFRFFFHSFLLLFLPPLSFFIFFPFFFHSFLLFFVLFHFLSFSFPPFFIPFLVLSLFPFFLVLSCLFFPTSFSSIFFPCLHLPFPLLFYSFIISFVFLSNFLFFILSLPHSLFCLSFFLSFFLSFFLCPLLSFFPFFFYYIRYSFFSCFICAFFLPYIIFVPSFLFPLSLSLSLSLSYSLHFYYFLCSFVPSSLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DRV2</accession>
    <name>A0A812DRV2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_59599</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004123">
        <property type="protein sequence ID" value="CAE1307508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DRV2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1307508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="313" mass="37163" checksum="A1619A169E3BE996" modified="2021-09-29" version="1">MKNHLIALSIYLSIYLSIYPSSLISIYPSLFISKSIHIYLSISVHSYSFYLSIYLSIYLSIYLSIYPSPFISIYLSIYLSIYLSIYLSIYFFYSLSIYLSIYLSIYLSLLIVIYLWHFKYCSIYIYIYIYIVTLILFYCYSVSHFIYFTILIYLSIYLSIYLSIYLSHCYSLSLSHCYSLSISRYSLSFNLSIYPFHCSYLSIYLSMFISIYLSMPIIYLSIYLSIYIYLSIYLSIYLSIYLSISLLLPLYFTIILSLNYPSISLFLSIYLSIYLSIYLSIYLTVTLSLYFTIFSLFLSIYLSIYLSIYLSIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DSD2</accession>
    <name>A0A812DSD2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_59348</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004111">
        <property type="protein sequence ID" value="CAE1307348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DSD2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1307348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="304" mass="36050" checksum="1A6F73124ABCA404" modified="2021-09-29" version="1">MTSLSAISYYILFALSRCSFSVVDYLPFPFPFLLSLLIISLYFFSLSFIPLYIRLLSFISFLSIFLPYSPTSSFSFLSLHLRSNLVFFSSYLTFILSPDISHIYNAFSLSLSLSLSLSLSLFFYIDFHLSFPFPTLFLLLGCISPHSSLTLFSKIFVCCFSSFCDIFLSFISSFSLRLFHGQMSFFFYMSFFFFLFPLDCLSLFRIAFLILCCYSLLFLIPFFFQDFCILFVSPLSLFHFWRFFLFSFFLSFFLSFFLSFFIFNFSLIFFLFPFFFFLSFFLSFFLSFFTSFYLLFFLFSSFPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DSE9</accession>
    <name>A0A812DSE9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_59577</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004123">
        <property type="protein sequence ID" value="CAE1307489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DSE9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1307489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="155" mass="18511" checksum="52581E0774B8A390" modified="2021-09-29" version="1">MFQKVTALRSGVTVLSREQLRGRDARYWRLCTGIMRHPTPSSAPANGIYQYEQRVKAYSDFLSLFLSIYLSIYLSIYLSKFTIYLSIYLSIYLSRFTKFTIYLSIYLSIYVDSLSIYLSIYLSRFTIYLSIYLDSLSIYLSIYIYIYIYIYIYIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DVI6</accession>
    <name>A0A812DVI6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_61242</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004322">
        <property type="protein sequence ID" value="CAE1309566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DVI6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032972052" evidence="2">
        <location>
            <begin position="20"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1309566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="213" mass="24723" checksum="40BA73B4B7C0CAC6" modified="2021-09-29" version="1">MLCLVSISILLLVSSTSESFFDRRWSKVSFYCSVTVTLLPYPSLYFSPFSAVNTSPSIFSFNSYSFTSTLHYLLLFLCANPPLFCFFFGSYVHLVVSYVLKVRLKKDILMESSFRSMQYLPLAWSTFISSITSRLVTRFNLIILFSSNIISLLYFHPFLHFSFVQLLFICSYFFISSFHSSKFSSISLSFLCFYFSSLFSEIYHSNIAFIFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DWH1</accession>
    <name>A0A812DWH1_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Laccase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SPHA_63681</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Farmed</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004570">
        <property type="protein sequence ID" value="CAE1312425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DWH1"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13884">
        <property type="entry name" value="CuRO_2_tcLCC_insect_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000045">
        <property type="entry name" value="Laccase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF394">
        <property type="entry name" value="FI03373P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032806314" description="Laccase" evidence="7">
        <location>
            <begin position="25"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="428"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="8">
        <location>
            <begin position="144"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="9">
        <location>
            <begin position="311"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="264"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="272"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAE1312425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="458" mass="50817" checksum="311A316E290587E5" modified="2021-09-29" version="1">MVDRIMILPFGVILIVVLLLPMSATEPCDMKADVCEYKFIVAYQLTMVKGKQLLKAVNGKLYPVETVNISTATPVPEDEVITMDGYSESRLVVAINGTIPGPAIEAYIGQTVIVYVENHLYASDVTIHWHGLHQKGTPFMDGVPYVTQCPIVNGRGRFYSQPGVHNEAPLAKFTVKPGKKYRFRVIAAGALYPFEISVDGHKLQIVASDGFELEPYAADVLLINPGERFDFIITANETIGNYWIRGITTEIKKNHTFEAILHYEGAPDEEPNSSPKNCTQDDPSDTPDVDCRGDPKKNYCNDAAWTNSNWGGDNIPGIKLKRAPLKDTLIIPSGGYAVIRIKADNPGLWFMHCHIEMHSMMGMAMILNESFVDVVKAPDYFPVCRSFTPEAISRIPIVAETSTSRASESTTPSIYQKAESEEDRKIEIMTFGILIAVICVLSLVIIVLIFVLSKRRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DWM4</accession>
    <name>A0A812DWM4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_62874</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004498">
        <property type="protein sequence ID" value="CAE1311466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DWM4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1311466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="300" mass="37027" checksum="C9A82D6122D41762" modified="2021-09-29" version="1">MPDKVSFFARLRWVLSSYFHLTVFLSSFFFYVSFFLIYSLFFFLRSFLLICSFFSFLSFHSFFFSYMFIIFISFLFSFLSSLFSFLYAHFFFLFSFIFFSFFLSFFLSFFLTCSLFFISSFFLSFFLICSLFSTLISLLLAYMFFLFFLSYMFVFFVSFRFLLLFFSFLSFLSFFLSILYVHYFYFFTSFFLFCSYVLYFFFLFSYIFFLIYSFFSFLSFFLFYMLTFLFASSFLSFFLSFFLSFFLSFFLSFFLSYSFFFSFLLSFLLFFFSSFFRKIKRISFLSTLSSFSTFPMTPRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DX19</accession>
    <name>A0A812DX19_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_60672</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004230">
        <property type="protein sequence ID" value="CAE1308867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DX19"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1308867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="198" mass="23245" checksum="A036A9626B1BF71A" modified="2021-09-29" version="1">MDNIWRIQQSISSKNIYLSIYLSIYLSIYLSIYQFPSDVYLSIYLSIYLSISFVHIYLSISICSHLSIYLSIYLSIYLSICNSEIYLSIYLSIYLSIYHCFPLSKFSLIYLCIYLSQFSTRLFLPVFIYLLIPTFIYRSLLLFMYAPNLHRSFLTYVSIYNYVVTIHHNHISLSLSLSLSLSLSLSLLPLFLVCYPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E468</accession>
    <name>A0A812E468_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_64055</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004609">
        <property type="protein sequence ID" value="CAE1312872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E468"/>
    <dbReference type="OrthoDB" id="8904524at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47641:SF1">
        <property type="entry name" value="GOLGI-ASSOCIATED OLFACTORY SIGNALING REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47641">
        <property type="entry name" value="PERIAXIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="223"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1312872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="385" mass="41064" checksum="771FD5C83C0D5DEF" modified="2021-09-29" version="1">MTFPSDQHLTFPKRSAPDIPKRSTPDIPKRSAPGISKRSPPDILKQSATDIPKQSAHGIPNRSTPGISKRSTPGISKRSTPGISKRLTPGISKRSAPGIPKRSAPGIPKRSTPGIPKRSAPDILKQSAPGIPKQSAPDFPKQSAHDIFKRSTPGIPKRSTPDIPKQSAPGIPKRLAPDIPKRSAPGIPKRSASHIPKRSEPDIPKRLAPGIPKRSAIEILASFLFHFLSLSLPPLSLSLSLCLSLFLSLFLRKFGSPPPPLSLSISLSLSLSLSLSVYGLFLTLFLCLVLSGLDLSLSLSLSLSLSLSLSCFLVSISLSLSLSLSLSLSLTLVYLSVSPSTLLTQGRRRILADSSAELGNLLLTRLPAPYHILSLSLSLSLSLSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E8Z4</accession>
    <name>A0A812E8Z4_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SPHA_68979</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005042">
        <property type="protein sequence ID" value="CAE1318538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E8Z4"/>
    <dbReference type="OrthoDB" id="7930430at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001498">
        <property type="entry name" value="Zinc finger protein 404"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF121">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="743"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="773"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="801"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="828"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="885"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="451"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="553"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="993"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="553"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="566"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="587"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="598"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="612"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="994"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1020"/>
            <end position="1030"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAE1318538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1101" mass="122328" checksum="51498A138CD0EDD7" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EAB7</accession>
    <name>A0A812EAB7_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">NADH-cytochrome b5 reductase</fullName>
            <ecNumber evidence="8">1.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SPHA_67555</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Farmed</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 8">
            <text>2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46680"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.2" evidence="8"/>
    <dbReference type="EMBL" id="CAHIKZ030004896">
        <property type="protein sequence ID" value="CAE1316903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EAB7"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090524">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NADH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF184">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 8" id="KW-0274">FAD</keyword>
    <keyword evidence="3 7 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 8" id="KW-0520">NAD</keyword>
    <keyword evidence="5 8 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032418357" description="NADH-cytochrome b5 reductase" evidence="9">
        <location>
            <begin position="21"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="10">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAE1316903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="224" mass="25896" checksum="611260FD222CAEFD" modified="2021-09-29" version="1">MFFFLSLSSLLHFQSLNIQAGQHIILRAYIKGKAINRQYTPINLICSKGYFELLIKIYPDGVMSQYLQTMKPGIEVEFRGPFGQFSMQQIVKFPRLFLLAAGTGIAPLSCVIESILDNEDDETFVHLLFACRYYGDILMKEELHDWLDFWNFSSLCCLSQDHSESVGFCKEPLHFGRITLDLLKTEIKDLCNTYFLICGSNSFNKDMVNFLLELQVPESQYFIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EAW0</accession>
    <name>A0A812EAW0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_71664</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005252">
        <property type="protein sequence ID" value="CAE1321604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EAW0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1321604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="279" mass="32636" checksum="CC450FF4DE2364AE" modified="2021-09-29" version="1">MGAKITWSSISKSFFFSLWIFPIFHDRNGPNLFMKNYVRPCLVLSIYLSIYLSIYLSIYLSIYHSVFLSISIYLLSSVHIYLSPFETIYLSIYLSIYLSIYLSIYVRSQLSQSIYLSIYLSIYLSIYLSMSVRNSLNLSIYLSIYLSIYLSIYVRSQLSKSISIYLSIYLSIYLSIYLSTSVRNYLSLFPSIYLSISIRNWIFSAFINPYFSLYLNLFIIYLSIYLSIYLSIYLSIYACSISIIYLFICLSISACSISIYLSIYLSIYLSIYLSIYLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ECP0</accession>
    <name>A0A812ECP0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_71076</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005202">
        <property type="protein sequence ID" value="CAE1320915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ECP0"/>
    <dbReference type="OrthoDB" id="75923at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.70.10">
        <property type="entry name" value="Transcription termination factor 3, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038538">
        <property type="entry name" value="MTERF_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="374"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1320915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="422" mass="49431" checksum="0E476F8E6BDDE24A" modified="2021-09-29" version="1">MLCTIIANHGLACIQILGKSIIGPVCHRQLFLFPVSLASKTTLSRTTLKKHFDEEVLFRQEYMTNTLMCSKKEVKDYLHNYDYLLRMKRNKFVKMIDLFATNYINVRDVLTYPDIFKRKYETVKMRIDDLKQNTDLKNIRLSMINVSQKEFNRRYQTYVEDTHARLQFHDKCGLLMKSLNCSEAVAASLINSSIWLDNSKLSTIQKKLDVYLSADPELTSVIQKRIWLLSFPLTDIEVKLNELKRLDVPTFIWKKSLNGLMKSTVWKSVQLSIYLSIYLSIYLSIYLSKSFAHIYLSIYLSIYLSIYLSPFSFYLSIYLSIYLSQSIFFLSIYLSIYLSIYLSNLSLFIFFFLSFFLSIYLSIYLSIYLSKSVHFYLSIYLSIYLSIYLSLSLTLSIFPVCSHLTVSVCSHLSIYLSIYLSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EJH3</accession>
    <name>A0A812EJH3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_72377</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005316">
        <property type="protein sequence ID" value="CAE1322391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EJH3"/>
    <dbReference type="OrthoDB" id="2017365at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="415"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1322391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="448" mass="52552" checksum="ED295F88B73D2779" modified="2021-09-29" version="1">MLSISIIHFTKFYLMTQQYLQNTLFPTQQNALFPTQSQHSRIHFSQHNRIHFSQHSRIHFSQHTAEYTFPNTAEYTFPNTAEYTFPNTVEYTFPKNSRIHFSQHSRIHFSQHNRIFPNTATQQNTLFPNTAEYTFPNTTEYTFPNTVEYTFPNTVEYTFPNTAEYTFPNTAEYTFPKTAEYTFPNTVEYTFPNTTEYTFPNTAECTFPKTAEYTFPNTTEYTFPNTAEYTFPNTTEYTFPNTVEYTFPNTEYTFPNTAEYTFPNTAEYTFPKTAEYTFPNTAEYTFPNTVEYTFPQQNTLFPTQQNTLFPTQQNTLFPTQYCFSLGVPENIIIFHSVYISTCLSITISFFLSFFLHYLSIYLSIYLSIYLSIYLAVYGGKKDNPTERVTLSRLTNFNIHGCKQAKTIYLSIYLSIYLSIYLLVCLSIYLFIFLSVCLSILYRSAYVPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EJQ6</accession>
    <name>A0A812EJQ6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_76852</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005498">
        <property type="protein sequence ID" value="CAE1327354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EJQ6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="282"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1327354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="312" mass="36160" checksum="6AF459B41C711E1A" modified="2021-09-29" version="1">MDKFCTNCSSAAKSFSYLSLSSSISTSYSLDLLFLSDRIYEISWAFTPSLSLSISTCSLSIYLSIYLSMFIMSMPVHYLSIYLCSLCLCLFIISMSVCLSIYVHNICVCVHYLSIYLCLFIIYLSIYVHYIYVCLFSMFIIYLSIYVHHLNLSMSVHGLMVYLGLVISLSPSIYLYSLSLFLSRSLYTYLSQPGCAYLSIYLSIYLSIYHTILFQHIWSSFSIHLSIYLFIFLPPCLSISLHFLSIYLSIYLSIYFFIFYLPVCLSPFSIYLSIYLSIYLSIYLLIFYLPVCLSLFIFYLSIYLSYSHIPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ELG9</accession>
    <name>A0A812ELG9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_74649</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005435">
        <property type="protein sequence ID" value="CAE1324973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ELG9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1324973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="203" mass="24191" checksum="DAE2415A2DD9F774" modified="2021-09-29" version="1">MFSIFFFLSFFLSYLVLSIFFSVFKISFFLNIYFKNLFPIVLSSLSPKFLSFFLSFFLSFFLSFFPYKNNVFLFFYIIHDSYNSPLYLSIYLSIYLSIYLSIYLCFCVCSSIYLSIYLSIYLSIYSYLSIYLSIYLSIYLSIYLSIAVCIYLSQSIQIYLSIYLSIYIYIYIYILHIPISICMSESVHIYLSIYLSIYLSISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ELY1</accession>
    <name>A0A812ELY1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_76435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005489">
        <property type="protein sequence ID" value="CAE1326877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ELY1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1326877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="248" mass="26623" checksum="CD20D0E7B780D769" modified="2021-09-29" version="1">MRAFITSLWATNYLTPSNLSLSSHSLLTLFSLSSHSLFLLTLFSHSLLSLFSLSDLTLFSHSPLSLFSLSSHSLSLYLSLSLYISHSLLTLFSLYLSLSSHSLLSLSLSLLSLLSLSLSFSSLSLSLSPLFSLSSLSPLSPLSLSSHSLLSLSSHSLLSLSISLSCLSSLSLSLSLVSLLSLFSLSHSLSSLSLSSHSLLSLSLSLFSLSSHSLLYLSRLSLFSLFSLSSLSSLSLKRDVASLSLLYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EM48</accession>
    <name>A0A812EM48_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_75057</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005448">
        <property type="protein sequence ID" value="CAE1325410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EM48"/>
    <dbReference type="OrthoDB" id="10309141at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032795319" evidence="2">
        <location>
            <begin position="18"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="116"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1325410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="312" mass="35568" checksum="EB3CEFDFBD6D8EBD" modified="2021-09-29" version="1">MPIVLLLLAAVIFSARCQYQPGKKKKDSKREDLTMESKMILPKLTITRIQVSKKEQMVQRRSRRRTCCMNDLFPRTCSPLKSHQTSSPCMSKSSDTHHHHDNDSYNSSYRGKIQSSDDSGLSSVSSTSPTPSIEDGEEEELILTDILDDKKRIPKKRSNSAPTLVRIDSFQDRAMRLMRKRHSKLQKHRQRAHSVNRNDENSEVFEPFSPTSSNTLLVPSPTSPDIMFALTSNSNGDLSVDRLVPDTNNNNVPDHAALIENANETVILTDSNGISVFITTKELVRSFELQRQIRKRRVNKKTMSFDENLLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EPU7</accession>
    <name>A0A812EPU7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_78214</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005532">
        <property type="protein sequence ID" value="CAE1328618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EPU7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1328618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="308" mass="36583" checksum="65A62FBFC67231E7" modified="2021-09-29" version="1">MLVFGSSCRKYQILLKTSLPVGSYFLKIFFFIFLHNNFVSFLVRLSPFTFHPHFFFFPQIRSLFFLEIISMNCLFTSFLKFNLLFFSLLLLSFVHSFFFLNGFCFSAFVFFLLSYSFLIFISFDVFFLFFVIYFRLSLIAFLLIPFLIPLFYSTFISSYCHSIFFLSVSSSSLYCFYISFLFSWFLFILSVPCLFSSSSHLFIALFIILFSSFIYSFLLLVTCLSFFLTFWSRYIWSLHSFSLPPFISFFFSFFSFYSFENKHINAKKLINIYLSIYLSIYLSIYLSQTTVSVNLIQAISMPYKCPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ER23</accession>
    <name>A0A812ER23_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SPHA_77887</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005525">
        <property type="protein sequence ID" value="CAE1328359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ER23"/>
    <dbReference type="OrthoDB" id="6099974at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF284">
        <property type="entry name" value="EG:103B4.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="187"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="222"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="308"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="374"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="398"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="442"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="466"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="3">
        <location>
            <begin position="95"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAE1328359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="504" mass="55172" checksum="ABF28D836F311393" modified="2021-09-29" version="1">MAIGDNGVNEPCNIFIVQCQANSTIDKSVLEKIPELHANYINVPPPSYDETILETSSQRASLTEDDIFETTAEVAYGNRSSRPSLIGERPLQIRDYLFISAAYFCSFCNVGFMNAFSILGIELLKTFSNSKAIILIIPAIGIGLSSAAGLLIGLLINKFGCSAVIIGGGVLQSLALLISVFGNHAIFLLFTMGVLLGIGCCCIYVTNAVFVGIYFGNRAPVFLSILATAGPTGAIVFPFLITFCVDLYGWRGTLLIFSGIFFNVIPCGIFLWFCQKKAENMTRKNIVQLPENVNTPKKLFDASVFKNLLFNVFLFAMSTTMGFMNIFITILPSFLFSKGFSLSMSAQAYSIMFITSVPPKLIMGIILKLTGWNFEYIFIVISLGFAIMSYIITLVTGFTPLLACCIMMGLLMGIPIGLYSLVILELIGRQKYSSAMGISETINGIVIICQGLISGVLISTYDSYEFPLYTFASVSIFTNLIMAASLGREHIKKMQFNLKLFSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ERT1</accession>
    <name>A0A812ERT1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_78846</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005552">
        <property type="protein sequence ID" value="CAE1329324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ERT1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1329324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="237" mass="27279" checksum="0812B12AF05EDC92" modified="2021-09-29" version="1">MKSSMHVSQIAYGADVQTRRLYSFSLLFFKTYPPPSPPHLLLLFLSFFLSFYFLLSLFLLLSFILFPFKSPSSPSFSSSSFFLSVFLSFFSFFSFFFFFFFFFLSFYFLLSVLLHLLLLLLLLSFCLPFILFPFKSPSFPSSSSSSSSFFLSFFLSFYFLLSLLLLLLLSFFLPFILFPFKSLSSSSSSSSSSSSDCFFSAILSQPILLVPRLSFIFFTYCNSFNNLRVFSSSSQTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ESW3</accession>
    <name>A0A812ESW3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_79331</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005565">
        <property type="protein sequence ID" value="CAE1329953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ESW3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="353"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="381"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="415"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="449"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="481"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1329953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="499" mass="60815" checksum="3BC81DFA9A08F9FE" modified="2021-09-29" version="1">MLFSLLTGIHFISSAFFLYFSIFIFFLFLSFCPHSYSFYFFFLFVLCIHFISFSFFLSFFTFILFPFFLSFSIFVLFLLSFCSSIHAPSSYFFPSPHSLYFFFFLSVLLHICFISSFFPHIHFLSFSFILSFYAFILFPHHFSFFHYIHIIIYYFSFFFLHYIHSVHSSFFFLSFFCHLFYYFSILFSFSAFILFFHSLLTSSYSFYFFSIHSFLLYIHFISFSFFLSFFHSFFLSFFLSFFLSFFLYIHSISSLFFFLSLLFLFLHPLFTYLYSFFFLSLHLFYFFLTFSTFFLFFLLFFVFLCIHFISSPFFSFPAFTSSFSFIIISFYFVSTFILFHSVLTFCNPFTSKLFLLSIFFFFIFSLDFFFNIFSYSLLLSFYFLIFNLSFSFSLSLLFNFSFLFLSLIIPMISLIFSHLFLSFYFIHTSFFTILLLLNYSYFLYFSFQIFLLIFLYYFQLLSFTFILLSLFQSFFFIPPSPSSLIFLFLFCLLLFLPFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ETA7</accession>
    <name>A0A812ETA7_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transmembrane protein 208</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SPHA_79970</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM208 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005585">
        <property type="protein sequence ID" value="CAE1330695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ETA7"/>
    <dbReference type="OrthoDB" id="10012212at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006624">
        <property type="term" value="P:vacuolar protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008506">
        <property type="entry name" value="SND2/TMEM208"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13505">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13505:SF7">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05620">
        <property type="entry name" value="TMEM208_SND2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAE1330695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="168" mass="19564" checksum="44A51680A23EF485" modified="2021-09-29" version="1">MPPKGKQGTKGQKQIVEENKKTLAFYQNIILTVNIIYFGVECIFFWDSFTALEIIMSCLAGLVYFGSFRFMKKMATPTWGEESTLLDGGIDLNLESGMAEHCKDIILMTVIVELLSLISNYFWLLWLLVPGRAFYLLWVNVLAPWFFEAPPEENEKKQRKLERKMRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ETK3</accession>
    <name>A0A812ETK3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_79631</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005574">
        <property type="protein sequence ID" value="CAE1330321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ETK3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1330321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="333" mass="40315" checksum="ADA3AAF5B316DA4A" modified="2021-09-29" version="1">MITIYGVILHTKIERDCSLSLTKLFLLPVLELLSFFFPSGFTFTSFILVCFLLLLCFHPILILILCRPFFFIFFITIFLYFFPLSQILCMLFLPLFFLILFMLFFFFSFSFFLCLFSFFFSSHSFCAFFFLLFFLCFFPFFLFFFPQSFYAFSSSFSSPHSFYVFSSSYSFYAFSLSFYSFFLFFSFFLCFFFLFFFSSFFLCFFFLFFFSSFFLCFFFLFFFSSFFLCFFFLFFFSSFFLCFFFFSFCSLFLIFSSCVSSHSFPSIDFASLFFFFLLLIFCLFSSFLLLISLLMYLLLLLPLLFLMLLLYYLLLPPWFSSCFTASSSFDYPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ETZ9</accession>
    <name>A0A812ETZ9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_80335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005597">
        <property type="protein sequence ID" value="CAE1331059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ETZ9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1331059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="173" mass="18488" checksum="B1CB5A0498921BDA" modified="2021-09-29" version="1">MCGDSPTILSATHLQSSRGTPLFGDTPTILSATHLRSSRGALICGVTPIMLSATHLRSSRGTPVCGDTPTILSTTHLRSSRDTPVCGGTLTLDDNRSSRDAVCGDTNNLSTTYLRDTPVCGDTPTILSTTYLRFSRGTPVAPTGSIYLSIYLSIYFSLLSIYLSIYLSIYLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EVY8</accession>
    <name>A0A812EVY8_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphatidylinositol-3,4-bisphosphate 4-phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.66</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SPHA_80841</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Farmed</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Signal transduction; phosphatidylinositol signaling pathway.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the inositol 3,4-bisphosphate 4-phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.66" evidence="3"/>
    <dbReference type="EMBL" id="CAHIKZ030005611">
        <property type="protein sequence ID" value="CAE1331688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EVY8"/>
    <dbReference type="OrthoDB" id="159395at2759"/>
    <dbReference type="UniPathway" id="UPA00944"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016316">
        <property type="term" value="F:phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039034">
        <property type="entry name" value="INPP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12187">
        <property type="entry name" value="AGAP000124-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12187:SF11">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-3,4-BISPHOSPHATE 4-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="6">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="7">
        <location>
            <begin position="121"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAE1331688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="982" mass="111470" checksum="118E0336C381B8D9" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EW21</accession>
    <name>A0A812EW21_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_80445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005599">
        <property type="protein sequence ID" value="CAE1331191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EW21"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1331191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="295" mass="31789" checksum="ECD0B0FC95E22B8D" modified="2021-09-29" version="1">MSYFYLHTHSLSLSLSLSLSLSLSLLASNSFLGTLFFLPLSLCWMSNQYDNWSQLPLSLCWMSNHGNWSQLPLSLCWMSNQYDNWSQLPLSLCWMSNQYGNWSQLPLSLCWMSNQYDNWSQLPLSSAGCLTTGLSFLCPSAGCLISMTTGLSFLCPSAGCLISMATGLSFLCPSAGCLISMTTGLSFLCPSAGCLISMATGLSFLCPSAGCLISMTTGLSFLCLSAGCLISMTTSLSFFCPSAECLPSMTTRLSYLCLSAGCITSMPTGLSFPCPSAWVSNQCDNWSQLSFAPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EXA1</accession>
    <name>A0A812EXA1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_80374</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005598">
        <property type="protein sequence ID" value="CAE1331141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EXA1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1331141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="391" mass="44926" checksum="C740B2514FFA7087" modified="2021-09-29" version="1">MSFKPGSLCYYQHGFVVDHSSIHARTNLTSAVFISIYLSQSVHIYLSQSILSIYLSIYLSIYLSQSVSFCLSVCLSIYLSIYRILSLTLYYLSIYLSIYLYFSYLTFYLSYLRESLHMCKDACVSLTHSAPFSSPPTPLCLLFFSSITQARLFANLGSSCFSSCSCSSSSSSTLNFSLCPLSPSLSFSLSPSPSLFLALLCNENSHFSLLISFAHSILYCNRFYLSILLPFLLSFLPSSFSFAPSICLSLIFVFFLSLFFFSIFTFFSLFFYLSLNNSFFFQTIFPFLRTFLFPSFQIFFIVIFLSIIHSFFVFETLGILLSLSYTNFFICFFINLSFFFLTILLIYSPSLAILLPIIFFLLFIFLFLWLFLSLHSFSFFIFAPSLFPFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AKR9</accession>
    <name>A0A812AKR9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_812</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000023">
        <property type="protein sequence ID" value="CAE1141420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AKR9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="324"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="357"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="398"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1141420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="427" mass="51049" checksum="BA6BDF4D07C60C58" modified="2021-09-29" version="1">MSCLTYLLRNANFRFFKNLCFRNHLSLNARRITSLSFSVSLSLSLSPSLYLSTHLNFYLSRFIGLLFTFLLCFLLSFYLLLSFFLSFFLSCKFVLLLRPLTSFLHFSLKVFGFLYFLLFFVGFFTAFSSRILFCFLFLSFFFSIYVRGISYRFFFLSFTFLLPLFLLFLFFLHLFFSIPFFLSFFLSFFSFLSFFLSFFLSFFQFSPLLFIFFNTIIHSVSHSFFHSFNLSFILSFFSFFLSFFLSFSFSPSVIHSFIHLIFLLFFLSFFLSFFLSFFLSVFPSVIHSFIHLIFLLFLLFFLFSFFSFFFFLSFSFQFSPLLFIFFNTIIHSVSHSFFHSFNLSFILSFLRSLQTLFCFFFTVSFTSLIGPFFSFFLSSILFKLSKHFYLFPFSCTSYFYHFIFISLYFSLSLSLSLSLSLSLSVTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AN20</accession>
    <name>A0A812AN20_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_2439</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000068">
        <property type="protein sequence ID" value="CAE1148473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AN20"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1148473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="158" mass="18377" checksum="F299D09D2C7147A2" modified="2021-09-29" version="1">MSVHIYLSIYLSGERERERERERERKRERGDRFSMFIYLTFLFLAFIHSLLSFSLSLLCSFSFTLSFLLSLSSLCSLLFLCSFSFSLSFLLSLSSLCSLLFLCSFSFSLSFLLSLSSICSLSFLRFLSFLLSLPFPSLYFFPFLSFLFSLSFFPSLFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AP59</accession>
    <name>A0A812AP59_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_1866</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000054">
        <property type="protein sequence ID" value="CAE1146629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AP59"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134:SF22">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134">
        <property type="entry name" value="OS08G0543275 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="277"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1146629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="357" mass="41696" checksum="808550CCA558E8EB" modified="2021-09-29" version="1">MEYISLHTNIHIAMLLSLSLWSFFNSSEIEKYLSMYVCMYVCMYVCIYLSIYLSISSQSVHINLSFPVCPYLSIYLSIYLSIYLFTSIYLSKSVHLSLSLSLSLSIYLSIYLSIYLSQSLHIYLSIYLSIYLSIYLLQSLNIYLSIYSHQSIYPSLSISIYLSIYLSIYLSIYHSLFTSIYLSQSVHIYLSIYLSIYLSIYHSLFTSISLSQYVHIYLSIYLSIYLSIYLSLTISIYLSIYLSIYLSIYLSAEWLKQSIHIYLSIYLSIYLSIYLSICQSVSVSSYLFQFFHLSLYLISFIYLSIYLSIYLSIYLSIYLSVCLSLFISISVFSSLSLSHFFHLSIYLSIYLSIYLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812APK1</accession>
    <name>A0A812APK1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_1877</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000054">
        <property type="protein sequence ID" value="CAE1146592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812APK1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1146592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="248" mass="30276" checksum="76761EA3F9129F0B" modified="2021-09-29" version="1">MFFLFLPFFLSSFLSYLLSSFFLLSFFSSFFHSFFFSLFTCIFSFLSLFLSFFLLFFLLLCLPSFFLSFTLSLILFLSIYLSIYLSIYLSIYLSQSLQYLFIYPSLFNIYLSIYLSIYLSISFEFFFLINFPHTFFFLPFSFFIFSPFFFLSFFFLFLFSSFFLFSSFFFLFSFLFSFFFSSFFIFFSFFLLASFFSPFFFLSFFLPFSFFIFFLLFFPFFLLSSFFSPFFYSLFFFFLVSFFLSGIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ARN0</accession>
    <name>A0A812ARN0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_5453</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000181">
        <property type="protein sequence ID" value="CAE1157973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ARN0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039715">
        <property type="entry name" value="ZCCHC10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13491">
        <property type="entry name" value="ZCCHC10 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13491:SF0">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="144"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="200"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="293"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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    </feature>
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    </feature>
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        </location>
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        <location>
            <begin position="905"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="937"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="967"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1007"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1043"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1082"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1109"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1136"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1159"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1202"/>
            <end position="1234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1157973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1248" mass="145070" checksum="02743AAAD9A8FAFD" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AVK3</accession>
    <name>A0A812AVK3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CCT6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SPHA_6592</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000215">
        <property type="protein sequence ID" value="CAE1160844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AVK3"/>
    <dbReference type="OrthoDB" id="10052040at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03342">
        <property type="entry name" value="TCP1_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000038">
        <property type="entry name" value="Chaperonin containing TCP1 subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000058">
        <property type="entry name" value="T-complex protein 1 subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.260.10:FF:000017">
        <property type="entry name" value="T-complex protein 1 subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000004">
        <property type="entry name" value="T-complex protein 1 subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012722">
        <property type="entry name" value="Chap_CCT_zeta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02347">
        <property type="entry name" value="chap_CCT_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAE1160844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="532" mass="58511" checksum="0876DCC574C3F58B" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AWN0</accession>
    <name>A0A812AWN0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_6471</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000212">
        <property type="protein sequence ID" value="CAE1160594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AWN0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="212"/>
            <end position="238"/>
        </location>
    </feature>
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            <end position="319"/>
        </location>
    </feature>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="431"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1160594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="455" mass="51903" checksum="4F3200D35550D062" modified="2021-09-29" version="1">MFSPQKSQWCRSSHQSQPENCRSFFCFFFFFLFFLTFNYLFLLFYFWSRFSWVLLYSTKSSTLHRNCTIPVATCHKQVFILLLSFFLFSCLFFFLSFSLCISRSLYLFHLYPSIFPLHLPILIALSIYCHFFLLHVLSLCHFVIIFSKISHLTSHFISSFYYLSLSIIYLSQSAHYLSISLSLLNICLSISVCSLSISLSLFIIYLSQSVHYLSLSFCSLSLSLSLSLFIISLSLSVCSLSLSLSLSQSVHYLSLSLSVCSLSLSLSLSLFCSFSLSLVLFIISLSLSQSVHYLSLSMSVHYLSLSLFIISLCVCSLSLSQSVHYLSLSLFIIYLCLFIISLSLFLFIISLSLCLFIISLSLSLCLFIISLSLCVHSLSLSVCSLSISLSLFFIYLSQPVYYLSLSVHLLPIIFFSFFLTYSHLKTLFKSFFNCMCFSLSLSLSGFFCSSFIHLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B0F8</accession>
    <name>A0A812B0F8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PICALM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_8549</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000279">
        <property type="protein sequence ID" value="CAE1165704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B0F8"/>
    <dbReference type="OrthoDB" id="44015at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="124"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="295"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="324"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="645"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="421"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="661"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1165704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="687" mass="76927" checksum="19C5A951A1BE0E99" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B2T0</accession>
    <name>A0A812B2T0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_8886</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000287">
        <property type="protein sequence ID" value="CAE1166406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B2T0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="390"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="431"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="458"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="493"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="517"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1166406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="536" mass="65276" checksum="6AE46C4CE5A28F11" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B313</accession>
    <name>A0A812B313_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CPD</fullName>
            <ecNumber evidence="2">3.4.17.22</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_11952</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.17.22" evidence="2"/>
    <dbReference type="EMBL" id="CAHIKZ030000400">
        <property type="protein sequence ID" value="CAE1172211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B313"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1172211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="250" mass="29421" checksum="FE0DB8D289E51CC4" modified="2021-09-29" version="1">MKILYKEAGYFHILDSSSLRNLLEIEFLNILDLSIYLSIYLSIYLSIYLLLTIFIDENCTLLENELHDINQHFMFYFLKISIYLSIYLSIYLSIYLSLFISVYLSLFISIYLSIYLSIYLSLFISVYLSLFISIYLSIYLSIYLSIYLSISVCSYLSFSVFSYLSIYLSIYLSLFISVYLSLFISIYLSIYLSIYLSIYLSQFVLIYFSLIISLLFSLAFGTDFLHRSLSLSLSLSLSLSLIFVFWKMRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B4A2</accession>
    <name>A0A812B4A2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_9828</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Spiralia</taxon>
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            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000313">
        <property type="protein sequence ID" value="CAE1168007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B4A2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="94"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="121"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="133"/>
            <end position="155"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="179"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="253"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="363"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="395"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="423"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="944"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="978"/>
            <end position="1000"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
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    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1168007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1001" mass="120046" checksum="8351A47BAB46D26C" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B5U8</accession>
    <name>A0A812B5U8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein SYNPCC7002_A1628</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SPHA_11038</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
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    <reference evidence="4" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000363">
        <property type="protein sequence ID" value="CAE1170319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B5U8"/>
    <dbReference type="OrthoDB" id="437693at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004407">
        <property type="term" value="F:histone deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09993">
        <property type="entry name" value="HDAC_classIV"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044150">
        <property type="entry name" value="HDAC_classIV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF19">
        <property type="entry name" value="HISTONE DEACETYLASE 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032380966" evidence="2">
        <location>
            <begin position="24"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="Histone deacetylase" evidence="3">
        <location>
            <begin position="86"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAE1170319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="371" mass="42375" checksum="F90EEF04716C66DC" modified="2021-09-29" version="1">MPYIFQLILFNMSMCLFYQNVLCQSKMMKNFLPKENIIPKKHVSSLNLDIQAEEFRKSSKKVTKYESKGLPIVHHYKYVSELPVGHRFAMKKFHGILRYLRQDNVISMKQVVEPCPLDMEKMSGVHTTDYLKKFFNGLTSDNEQRRTGFKWTPGLVERCQYETGGTLLAAQIAHQKGLACSTGGGTHHAFPSYGSGFCLVNDLAIAASQLKEQKLAKKILIVDLDVHQGDGTAFIFQNDLDVFTLSMHCQNNFPLTKQKSDLDIELENFIEDLEYLAILKEHLPHVLNTFRPEFVFYDAGVDPHVNDELGYLNLSDQGLFDRDYYVLKLLASHGIPCATVVGGGYSTNREQLYIRHTIIHRAATKIWNENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B821</accession>
    <name>A0A812B821_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">SPHA_11493</name>
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    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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            <authorList>
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                <person name="Bekaert M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000379">
        <property type="protein sequence ID" value="CAE1171282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B821"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
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            <begin position="12"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1171282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="194" mass="22849" checksum="BDD6DFC7AC441AA4" modified="2021-09-29" version="1">MVIFFFFCEKAYAAAACAHCYLVCLLKPYVKRHGFWSLNDLRSKLSFFLLFSFFFPFFLFSFLFDFCFLDLFFLSCFPSFFNLISSLFNFISFLFSSFPISFIFHFFFFFFYKFFTLSTSSFSFFLSFFLSFFLSFFLSFFLLSCEPLFQQLSLTAGKQSVSHLPNFSLPNILKVFSGRRPTEEKGGADKSPTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B860</accession>
    <name>A0A812B860_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_12620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000421">
        <property type="protein sequence ID" value="CAE1173405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B860"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1173405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="213" mass="25660" checksum="CA3583192855458D" modified="2021-09-29" version="1">MYNSFSAKTNAHFRIGFLFPNIIYLSIYLSIYLSIYLSIYLSIQILSGQRCIYLNLGETTHLKSVDREGHYLFTQLSRLVDLYRLLRMSHVSILSISFFLSFFLSFFLSFFLSFLFFCKVFSFHPTFFLRFLSFFFFLSFFSFFILRLFSVFSNSIRLLVSFSFLFFFLFSLSFFLSVIEYSFVSSFFFLSFFFFVSFYFLSFSFFSFLINFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B8Y7</accession>
    <name>A0A812B8Y7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_12913</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000432">
        <property type="protein sequence ID" value="CAE1174024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B8Y7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134:SF22">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134">
        <property type="entry name" value="OS08G0543275 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1174024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="338" mass="39912" checksum="BF3725BC1202D327" modified="2021-09-29" version="1" fragment="single">YSYLSIYLILFVSIYLSSKSVHNFLSIYLLTLFVSIYLSIYLSLFMFICLCIFISIYLSIYLSIYLFFYLSSKSVRNFLSIYLSSFSPFHVYLSLHIHIYLSIYLSIYLSISAFSCLSVSVYSYLSIYLSIYLSIYLSLSSKSVRNFLSIYLASQSVRMYVCMYVCMYLSLFMFIYLCIFISIYLSIYLSISAFSCLYVSVYSYLSIYLSSKSVRIYLSIYLSIYLSIYLLSLFVCMYVCMYVCIYLSIYFSLFMFIYRCIFISLSLSLSIYLSYKSLRNFLSIYLSIYLSIYLSQPFHVYLSMYIHIYLSIYLSIYLSIYLSSVYLRMVAGSKMNIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BDW3</accession>
    <name>A0A812BDW3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_18145</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000654">
        <property type="protein sequence ID" value="CAE1231546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BDW3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="26"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1231546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="261" mass="29463" checksum="84D116DA3A7DAD96" modified="2021-09-29" version="1">MTSQSLVKIKDLRLFTPQLSDRIHQYLLIVIVLVAVTLAVPITAGLSICCIRCNDRRKAARKAAAVKLPKKTFNQQRHLIVHPHLAAAWSDAPVVRGSAPNRARPPPPVRQKRAVPSSDKYAKGRKSSVLSTRLQKVTDVIYQEIDDVDGNDQRQFMIADSQRQLITTHTDSEDAWSDGDIRGTRQPPVVTNADYVEPRQTNENQTQNRYMEPVQQKFFFPEDKIISSRRFNRPNIAHVPDCSQWLDASPSTVDSGISDMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BFF3</accession>
    <name>A0A812BFF3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_19099</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000691">
        <property type="protein sequence ID" value="CAE1233730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BFF3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1233730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="270" mass="31930" checksum="C62B0765AF2FD706" modified="2021-09-29" version="1">MPPSKFYLSIYLSIYLSIYLSISIDRSIYLSIYLSIYLPTYLIFRCWICHKSIFFKKKKAKIVIYLSIYLSIYLSIYLSIYLCPTIHYLSIYLSILLCSLSIYLSIYLSIYLSQSVQYLTTFSICRYPSLSLDLSIYLSIFDYSNVFVYISIYLSSIYLSIYLSIYLSLTIQMSLCTYLSIYLSIYLSIYQAIYSEDKLHGSARSIYLSIYLSIYLSIYLSDHVYSNHLSQFVYYLSIYLSIYLSIYLSIYLCFRSRICQPCLFKKVFNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BJA6</accession>
    <name>A0A812BJA6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="14">V2R</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SPHA_16606</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000587">
        <property type="protein sequence ID" value="CAE1227917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BJA6"/>
    <dbReference type="OrthoDB" id="6133044at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.50.30:FF:000004">
        <property type="entry name" value="Taste receptor type 1 member 3-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.30">
        <property type="entry name" value="GPCR, family 3, nine cysteines domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000337">
        <property type="entry name" value="GPCR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011500">
        <property type="entry name" value="GPCR_3_9-Cys_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038550">
        <property type="entry name" value="GPCR_3_9-Cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000068">
        <property type="entry name" value="GPCR_3_Ca_sens_rcpt-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24061:SF0">
        <property type="entry name" value="C-FAMILY ODORANT RECEPTOR OLFCT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24061">
        <property type="entry name" value="CALCIUM-SENSING RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07562">
        <property type="entry name" value="NCD3G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00248">
        <property type="entry name" value="GPCRMGR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="330"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="363"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="502"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="553"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="598"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="628"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="domain" description="Receptor ligand binding region" evidence="12">
        <location>
            <begin position="38"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="GPCR family 3 nine cysteines" evidence="13">
        <location>
            <begin position="223"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAE1227917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="661" mass="75192" checksum="A9CA645ABB5B40F7" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BL53</accession>
    <name>A0A812BL53_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_18709</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000675">
        <property type="protein sequence ID" value="CAE1232797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BL53"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1232797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="155" mass="16947" checksum="E4F86FA2233351F6" modified="2021-09-29" version="1">MYLLSSFHTYFTISLYKSCLFISISNPSHLSTSLVLSLSVLSSLNLSGILYLFDPSARLGHPALIRSPCSSCTHPLALLTLHSSARLAHPALIRSPCSPCTHPLALLTLHSSAHLAHPASMSQFSYSHLSTYFNVLILPQSVHIYINLFISINLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BLY2</accession>
    <name>A0A812BLY2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_19136</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000693">
        <property type="protein sequence ID" value="CAE1233897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BLY2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="336"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="374"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1233897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="397" mass="46957" checksum="9964C2DBC76EE61F" modified="2021-09-29" version="1">MVLCVSTSRLSLSLSLSLSLFLFTSSHFSTTVVLSFFVLIFKVTSFIFCGILFVLLSLHFLIIQVPLSSFFSSFSSFFLSFLCHHSSFHASFSFFPFFFLSLFLLVCLFLSFYSMSPFSILCFILLDCLFLSFFYSILPYSLPCFISFLSFFLSFFLSFFLSFLSFLFYCLLSISSSFFLFILSFYCLLSISSFFLSFFLFLSFLSIVYYQSLLSFFLSFFLSFFILSFYCLLSISSFFLSFFLSFFLSFFIFSFYCLLSISSFFLSFFLSFMSPFSLPCFISFLSYFSFFYLYFFYSVLGHYPVCHSFFLSFFLSFFLSFFSTLCHHTVCHAAYLFFFFLFSFFLSFFLSFFLSFFLLYANVQSSMLPFLSRFLLSFFFMPPFSLPYFIFFLSLFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BM50</accession>
    <name>A0A812BM50_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_20255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000744">
        <property type="protein sequence ID" value="CAE1236489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BM50"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1236489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="290" mass="35993" checksum="1209769A181E784A" modified="2021-09-29" version="1">MHNYIHIGRNINILFVDDSSETKRYPHLYQLHIYLNLCIFTTTNFNFCFLSSFFLPSFSSSSFSLFSSSFSLFSFSLFFYFHLPFLYFLLPFLYFLLLFLFVFFLSSFFFIFFLFSIYFIFFTFLLFFICLLSSFFFIFLFSIFFFLFSISSSFSLFSFCFLFVFFLSSFFFIFFLFSIFFFFFFIFLLFFICLLSSFFFFFLFSIFFFLFSIFFFFFFIFFLFFICLLSFFLLFHLLPFLYFLLLFLYFPSVFHLPSFFLSFFLSFFLSFFLFLYFSLPHLLHLLYFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BM99</accession>
    <name>A0A812BM99_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_20343</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000746">
        <property type="protein sequence ID" value="CAE1236635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BM99"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1236635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="273" mass="33084" checksum="8BB89F1472D363D9" modified="2021-09-29" version="1">MTPSQMTLSGEKIDLLQLFFISLIFFSFYSWLLFIFFILYRPSFSLSFSFVNFFIHSFFFYFFILHLFFFYLRFLSFFLSFFLSIFHSFFLSFSFISFSFVPFLFICLFLSPSLILSFILIFSFMPSSIFFLLSFFLLSAKFTFWLSFFILSFFLLHTLFHSLFLFFNFFLSRFLPSLSFTVYFILIPASLHSFLLCLSFILSFVFFLIHEFFYSLILLFVLHSFFLIHKSLHLFLLSIFFLSFFLSFFIFFFFVWLLILLSGLLPFIAFFIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BML3</accession>
    <name>A0A812BML3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_19482</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000706">
        <property type="protein sequence ID" value="CAE1234685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BML3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="265"/>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1234685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="346" mass="39868" checksum="337163647F396C1C" modified="2021-09-29" version="1">MSWRADGTRPNVPLQWPRCGLRARQNDTHDKSSGPNASIVSPPGHFMFISFSLYTYIRTVSIYLSLFTSIYLSIYPVPYLPVLSPLSLLSFYRFACPSPSLPLLITFEASFCLIYNSPFVFISSSISFLSSLFLTLFPFLSTSFIILIFFLPLLHPLPSSRERFLSPSLLNFLPPLLIYVLLSLFVFAYSLWSLYFSFGLLYFPLYLFSSFLSFFFKLFLISSVVSSYSFHSLLSLSLSFYCLFILILFPSLSFNIFTVSFSLFFSPLNSSAHHFRIHHGRRPDGHSPCGRWSVSLYDTVYGRLLIRPIHYQPLATFRCTFFLSFFLSYQSIPLFSSHYLSIYLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BUX9</accession>
    <name>A0A812BUX9_ACAPH</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_24088</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000894">
        <property type="protein sequence ID" value="CAE1243990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BUX9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <end position="56"/>
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            <end position="119"/>
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    </feature>
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            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1243990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="193" mass="21513" checksum="29482BB41524DC85" modified="2021-09-29" version="1">MHSLSLSLSLSHTHTHTYTHSLSLSHTHTHTLSRPFSLSFSLSFSFSLSFYFFLSLPFSLSVSLSFSLFLSLSFSLPFTLSLSFSLSFSLSLSLSLFLSLCLSLCLSLFLSLFPSLYLSFSLSLSFSLSSFLSLSLFLFLCLSLSLSLTFSLSLTFSLFFSLPFTLSLFLSHAHVFSVAFIYVHIQSRLSNAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BW43</accession>
    <name>A0A812BW43_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SPHA_26509</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
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            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
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                <person name="Bekaert M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="CAE1249302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
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        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
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            <end position="58"/>
        </location>
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        </location>
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    </evidence>
    <sequence length="2007" mass="236366" checksum="B73F923CBA63E80F" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BWK3</accession>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1242772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="264" mass="30816" checksum="27BD9FF3268ACCAC" modified="2021-09-29" version="1">MVIKRGVLASLRLLVVLRFPGRRVSTARVYVRLAERGIEKKVTDRIHRKLSRVLIFINLHSFNHFFSFSARLSFLTSAILHPLSILLLSSFISHLYSSLCFSFFFFPHIFLGPFSLISSPLSLTSLSYSLINVRRRLFDFLFHLFSFFSFSFLFYIIISGLFSIFISSYPLLRPSPFYSMYFNYNLLFISLVSNSLLLLNFLAYSYYVFLSLTSPISPFISHLFYAFQVCSSLDLIPSRSFIYLPSLFPTISFSFFYCLHHCHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C181</accession>
    <name>A0A812C181_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_27970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001101">
        <property type="protein sequence ID" value="CAE1252394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C181"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1252394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="243" mass="28416" checksum="7D4E991F277BC483" modified="2021-09-29" version="1">MRSASCYYRGINTASVPIKAVKAFLFPCCFCFSFYISFLFLFLFEFLFFIFFHFIFSSLFFFSVSIFSFFSLSFFLYFSLFFHSVSLIFFLYFSFFFFFFFSFFHFFPFLFLFFFLFVYLYIFFPGSLFSLFCFSSFFFPFHFSNTPHPPPPFWSSPPFLFLFSFFNISPCHLLFLLTPSLSLSLSLSLTLSLSLSLSLSLSLSLSLSLSLSLSLSLSTAPGLVAWVFPRLANDNFCPSSLQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C2U0</accession>
    <name>A0A812C2U0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">TBXAS1</fullName>
            <ecNumber evidence="11">5.3.99.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SPHA_30287</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Farmed</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.99.5" evidence="11"/>
    <dbReference type="EMBL" id="CAHIKZ030001216">
        <property type="protein sequence ID" value="CAE1256602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C2U0"/>
    <dbReference type="OrthoDB" id="6148150at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008395">
        <property type="term" value="F:steroid hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004796">
        <property type="term" value="F:thromboxane-A synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000182">
        <property type="entry name" value="Cytochrome P450 3A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050705">
        <property type="entry name" value="Cytochrome_P450_3A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24302">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24302:SF15">
        <property type="entry name" value="FATTY-ACID PEROXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9 10" id="KW-0349">Heme</keyword>
    <keyword evidence="6 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAE1256602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="269" mass="31546" checksum="8E6FEDAF97CF4466" modified="2021-09-29" version="1">MRYFIDFCKELVEERRRHKDNSARKDLLQLMLDAQLEGHEKLDKKTEQELKLENVTDWRTKRGLTDVEIIAQCMIFFLAGFDTTATTLSFFAHSIATNPDVQEKLYQEIKEKLEQESPNYDNVQKLTYLDMCLDETLRMYPIGFLLSRESKEDCIIKGLKISKNTGVLISTMTLHYDPRYWPEPEKFDPERFSEENKAKQIPFTYLPFGGGPRICAGMRLAQLEFKMAVVQMLRKFRLVSCDKTEKKIEFAKAGLLKPKNGVWIKIEHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C536</accession>
    <name>A0A812C536_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_29814</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001193">
        <property type="protein sequence ID" value="CAE1255745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C536"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1255745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="173" mass="20808" checksum="B4B583D8E036F2D4" modified="2021-09-29" version="1">MTVQSSTLFRYYDCPEQYSFSVLCLSRAVLFFGIMTVPSSTLFRYYDCPEQYSFSSLFLSFLFPSYTFSSLSFFTYFVSVFLMFFSNVLSLIIFFFFVIIFIHFPSFLLETLLPFCIFFLFAYSFNNFLSLLLTSYFRFISRFFFFSLFDAFILFLISFLFFPLSIFNFFPHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C5F1</accession>
    <name>A0A812C5F1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_28633</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001121">
        <property type="protein sequence ID" value="CAE1253843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C5F1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1253843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="212" mass="25026" checksum="9BDA70051EFA1BB3" modified="2021-09-29" version="1">MPTSFSHEKGDTISISDLLPSLFFRVLFRAIAPFFITICFFLFWSDSFQPVEFFINFVSVRILLFTLFYPVKVQISQPYKSPRTSLEETEPTLAITQYPIFKPIYLSILIYLSYSVQYLSNYLSKAIRKYHLYNNCSYLSIYLSIYLSIYSKSYLSNYLSKSVLIYLSIYLSIYLSIYLSIYLSIYLSVRKYSPIYLSLSIHHILFSIYLII</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C7H0</accession>
    <name>A0A812C7H0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_28328</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001112">
        <property type="protein sequence ID" value="CAE1253199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C7H0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1253199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="349" mass="38669" checksum="DF99FE75DE7D971D" modified="2021-09-29" version="1">MTTESKVPSEGTLSRYDRLTVLKKLFHNKCSTPGPLFTPPNPSSLPLSVSFFIRVFLLFRSLSPLHYYSRLCANILSCLIKCHRLRPKTPTCRVSNLLHQLTSLYTPSLSRGHSEYIYYLCVMAFLLNGGLSLSILLSPSFPSPSLSLSLSLSPSICISLFSSDLPHYLSHFQSFYLNSLFLLSPPHSLSHSQSFYLHLSLPLSPSHSLSLSILLSPSLSFPTLSVTLNHSISISFFPSLFSTLSISHSQSFYLSISLFLPTLLPLHSLNPSIYISLFPLSPSYSLSHSQSFYLHFSLSLSPSPTLSLFLSILLSPSLSFSCLSSPSLSLTPSHSIPLLTVCVRLHHRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C8H2</accession>
    <name>A0A812C8H2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_34619</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001475">
        <property type="protein sequence ID" value="CAE1265330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C8H2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1265330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="159" mass="18810" checksum="46B7EABF603167BB" modified="2021-09-29" version="1">MFSYPFSVNRKLQFKVSCTEKVFCSFTENNQQPPQGIFEEIPINDEYRNLKKRTLLNLLLVFFFFFFFLFFFFFFLLNRGKSIQSFLVCSPSSFPTNFIVSPSSLDSFLNFSPQLKILSSSSSSFFFFFSFSSSSQMFPFLLFFEFLLPYLFLLLLVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CAB7</accession>
    <name>A0A812CAB7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_31223</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001273">
        <property type="protein sequence ID" value="CAE1258388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CAB7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1258388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="193" mass="21590" checksum="A01270A8D77180A9" modified="2021-09-29" version="1">MLSLALSHTLFLSLSLFFFSLSLLHTFSLSLFCTPSLFCTPSLSLLHTLSLSFAHPLSLSCTPSLSLLHTFSLSLSFAHILFEVHWFCLCSPGPFPFAFARLVAFIYLGSPGRFPFALARLVAFLLPWLAWSLSFALARLVAFLLPWLSPGPFLLPWLAWSLSFCLGSPGRFPFALARLVAFLLPWLAWLFEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CBZ4</accession>
    <name>A0A812CBZ4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_31978</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001326">
        <property type="protein sequence ID" value="CAE1260041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CBZ4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1260041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="289" mass="33828" checksum="0031A6A13CE07F0C" modified="2021-09-29" version="1">MIKTYLFLLPFPCHIQVIYLSHSLSIYLSISACSYLSIYLSIYLSIAVYIYLRLFINYLRLVIIYLSLSLSVNLSIFLSMQSIYPTISVCYIYLSRSICIIHCIYLFISVFSYLSIYLSIYLSISLHIYLSIYLSIYRSLFVSINLSHTLSIFLSLFIPIYLLFIFLFIAVCIYLYLSIYLSIYLSIYLSQFVLCRSTNLSITICIHHFICLSMSVCLSQPVHIYIAMSFCSLSIHRKLYLSIYLSLFISINLSQFLHIYLFILICSLFICIIYLSQSVHVYLRDTIFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CD23</accession>
    <name>A0A812CD23_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_32602</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001358">
        <property type="protein sequence ID" value="CAE1261132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CD23"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="13"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1261132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="223" mass="27210" checksum="C25FAFAA09D71951" modified="2021-09-29" version="1">MEFYFIFSTSFSLFIYLFNLCISFFLSFFLSFFLSFFLSILRISIYLSIYLSIYLSIYLIFAFYLSNHRIFIYLSIYLSIYSLDFYLSFYFHLSILYISIYLSIYLSIYLSIYLFFRFLSIFLSIYLSIYLSIYLSILTFSNIYLFFTFSSIYLSIYLSIYLSIYSLNFYLSFYFHLSILYISIYLSIYLSIYLSIYLSIYLFFTFPSIYLSIYLSIYLSIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CD82</accession>
    <name>A0A812CD82_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_32687</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001365">
        <property type="protein sequence ID" value="CAE1261375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CD82"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1261375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="226" mass="27292" checksum="8299840EA13EC11F" modified="2021-09-29" version="1">MTYSFFLYHFILLFFITSFFFVTLSFFSLSRLSFLSLLSSVSRFLSLSLLSTLSLLPFLYHIFPFFITLYCVTSSFFVTSFFSVTYSFFSLSLLSSLSLLSFFITSFFLYHFFLLYQFFFFINSSFFSPLSLPPFFFLYHFFLLRYDFFLSISSSFECSYLLFLFPFFCFPRLFHHFLFFRFVPFSFFFLPILLPHLFSCHLTPTSVQDANKMWETFKLNQLERKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CDI0</accession>
    <name>A0A812CDI0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_34022</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001435">
        <property type="protein sequence ID" value="CAE1264057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CDI0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1264057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="200" mass="24479" checksum="C9D1759D916A6509" modified="2021-09-29" version="1">MKEAAAAKKERQFLGLSFPSFLSILPFFFFFHLNLFFSFFLFLSFFLSFLSCFLLSILSIILIFFFLYFLFLSFFLSNFLFFLSFFLHSIASPFFLIVLSFFFLSFFLSFFKFLFNFLFLLFLAVILFFLSFFLLSFFFFFLSSFHFPCGNFLSFFFLFFLSFFLFFLSFIPSWSFLLSYFSFFFLFFFFLSFFLFSFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CEE5</accession>
    <name>A0A812CEE5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_35385</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001520">
        <property type="protein sequence ID" value="CAE1266891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CEE5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="116"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="163"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1266891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="183" mass="20291" checksum="A01A0C0872E45DD3" modified="2021-09-29" version="1">MCATLRNDSCGICGGNGSSCNRLDSFWPRIIPSSTTKIDVFGAGFNPIISVLLLKNGSQINDTVWKIKNSTFLQMTVTLEPGLYKLRVNFNSTFSKDSMANLTVYNKTSKYSCHCLITLIVSFFFFFFIFFFFSSSSSCFFFFFFFLLLLLLLLLPPSPPPLSSSSSSSSSSSSSSSMCRIPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CH68</accession>
    <name>A0A812CH68_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_34664</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001477">
        <property type="protein sequence ID" value="CAE1265417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CH68"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1265417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="153" mass="17936" checksum="F26D3B3D26469192" modified="2021-09-29" version="1">MYLPEYIDNYLPIYLSIYLSIYLYIYSFLSFFLSITMFLSINPSISASPLSLSLSIYLYTYICPFLFTFYNLYLSIYLSINLSIYLSQYVSIYLPILSFSFPPSIFFLKFFLPQFYHSILILVSSSLSLSLSLSSAFSFLFTSCLFIYRFTPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CHQ5</accession>
    <name>A0A812CHQ5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_39387</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001824">
        <property type="protein sequence ID" value="CAE1275294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CHQ5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1275294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="435" mass="49275" checksum="89B63636EF386532" modified="2021-09-29" version="1">MHFSLSLSLSLSLLYLSIYPSLFLATVTCRCIIALSSKILPQIAISTTASPRNTYGEPTAVISYPSARTNPDCCPHLYCHNIIISTFARSIYLSIYLSIYLSIPVYSYVSIKLAKYPSLSVCSSLFISIYLSIYLSIYLSIYLNLFISIYLSIYLSIPGYLYLSIYLSIYLSIYLSISVYSYLSIYLSIYLSIYIYIYIYIYIFLSQPIHIYLFIYLSISVYSYISLYLSIYLSIYLFQSIHIYLSICCESILNKLSLSLSLSLSNFLVIYLSPLTSHLFILPSLSLSLSLSPPPLMPLSSLFVSHHFSYLSHSLLQTLSIYINLSLTFYLSVPHLSPSLPISIALFSSLFRSSSLSIFFSLSPPSLLFIALSPYHSLSFNLSLFISLHPAHFFYLYFNSLSLSFSLPSPLMPLCLSLSIPPIYPTLSFKLSLFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CN37</accession>
    <name>A0A812CN37_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_40362</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001902">
        <property type="protein sequence ID" value="CAE1276828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CN37"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1276828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="284" mass="34377" checksum="36F524E17ABCA120" modified="2021-09-29" version="1">MCNFQISLSLSFFLSIYLFISLSFFLSIYLSIYLSLSFYLSIYLSIFLSFFLSIYLSIYLFLSLSFSIYLSFFLYTLVNGIAYCPVYLSIYLSIYLSIYLSIYLSIYLLQDIIIYVCMYLHLSIAYILFFYFFALLRLLLLCPRRRPSSHFSSFSHFVSLLLLLSLFSSFVDFFPLSILFFKYSLLLSSYRLLLLLLHILFLCEYSLLLFLILPILFLLEIIASSSFFLLLPSSSNLFFFFFPFCKYFFFFFFFFFFFFVFFFFFFFFFLFFYIIVFFTERKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CNE5</accession>
    <name>A0A812CNE5_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.155</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">SPHA_40409</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">Farmed</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>N(4)-{beta-D-GlcNAc-(1-&gt;2)-[beta-D-GlcNAc-(1-&gt;4)]-alpha-D-Man-(1-&gt;3)-[beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = N(4)-{beta-D-GlcNAc-(1-&gt;2)-[beta-D-GlcNAc-(1-&gt;4)]-alpha-D-Man-(1-&gt;3)-[beta-D-GlcNAc-(1-&gt;2)-[beta-D-GlcNAc-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16921"/>
            <dbReference type="Rhea" id="RHEA-COMP:14374"/>
            <dbReference type="Rhea" id="RHEA-COMP:14377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:139507"/>
            <dbReference type="ChEBI" id="CHEBI:139510"/>
            <dbReference type="EC" id="2.4.1.155"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.155" evidence="5"/>
    <dbReference type="EMBL" id="CAHIKZ030001905">
        <property type="protein sequence ID" value="CAE1277093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CNE5"/>
    <dbReference type="OrthoDB" id="2113294at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030144">
        <property type="term" value="F:alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026116">
        <property type="entry name" value="GT18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052105">
        <property type="entry name" value="MGAT5_Glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027833">
        <property type="entry name" value="MGT5A-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15075:SF2">
        <property type="entry name" value="ALPHA-1,6-MANNOSYLGLYCOPROTEIN 6-BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15075">
        <property type="entry name" value="ALPHA-MANNOSIDE BETA-1,6-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15024">
        <property type="entry name" value="Glyco_transf_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15027">
        <property type="entry name" value="MGT5A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 19" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="8 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="64"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="158"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="188"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="219"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="MGT5A-like N-terminal" evidence="18">
        <location>
            <begin position="300"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase family 18 catalytic" evidence="17">
        <location>
            <begin position="433"/>
            <end position="997"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF15024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF15027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CAE1277093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1013" mass="120536" checksum="D1C61D3A9625C8DD" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CNN4</accession>
    <name>A0A812CNN4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_42189</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002049">
        <property type="protein sequence ID" value="CAE1280206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CNN4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032769360" evidence="2">
        <location>
            <begin position="24"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1280206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="229" mass="25426" checksum="C6ECA21F534D035D" modified="2021-09-29" version="1">MFNKGTTVTQILLTSTCLHLVSAFPPPLSLSLSLSLNLSLTLYLFKVFLSLSISLKSFSHSLSLNLSHSLSLKSFSHSLSLKSFSHSLSLKSFSHSLSLKSFSIFSLFNSFSLPFLKPLCSLSYKFFPVSLSPLSFQSLSPSSLFLISFFSPLSFSSLSFSPLFRVSLFLPSLFSLLFLPLFSLKFSPLFSVSLFLPLSFQSLSLKSSCLSPRTNQTEIWLKNTHFSCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CRV4</accession>
    <name>A0A812CRV4_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Dolichyldiphosphatase</fullName>
            <ecNumber evidence="2">3.6.1.43</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SPHA_39874</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Farmed</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Required for efficient N-glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. Does not act on phosphatidate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a di-trans,poly-cis-dolichyl diphosphate + H2O = a di-trans,poly-cis-dolichyl phosphate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14385"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19506"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57497"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="EC" id="3.6.1.43"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dolichyldiphosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.43" evidence="2"/>
    <dbReference type="EMBL" id="CAHIKZ030001872">
        <property type="protein sequence ID" value="CAE1276165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CRV4"/>
    <dbReference type="OrthoDB" id="302705at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047874">
        <property type="term" value="F:dolichyldiphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247:SF1">
        <property type="entry name" value="DOLICHYLDIPHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247">
        <property type="entry name" value="PALMITOYL-PROTEIN THIOESTERASE/DOLICHYLDIPHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="1 2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="3">
        <location>
            <begin position="61"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU367078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAE1276165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="164" mass="18996" checksum="9507AEA066242288" modified="2021-09-29" version="1">MDVEEGGDPNHVQWIPLSLLFVEYPAGDLIGYILAWFSIMPIFISIGFLTLIIIRRDLHTVSYFLGILLNELVNTILKHIIKDSRPAPSPTQTPHGAYGMPSSHSQFMWFFNTYLILFLLFSFLGEFLMVRDSTLIPHVMWFEYKSSRSEARNRQRKVTGRKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CS53</accession>
    <name>A0A812CS53_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Putative hydroxypyruvate isomerase</fullName>
            <ecNumber evidence="4 7">5.3.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SPHA_40755</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Farmed</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>3-hydroxypyruvate = 2-hydroxy-3-oxopropanoate</text>
            <dbReference type="Rhea" id="RHEA:11952"/>
            <dbReference type="ChEBI" id="CHEBI:17180"/>
            <dbReference type="ChEBI" id="CHEBI:57978"/>
            <dbReference type="EC" id="5.3.1.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the hyi family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.22" evidence="4 7"/>
    <dbReference type="EMBL" id="CAHIKZ030001935">
        <property type="protein sequence ID" value="CAE1277583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CS53"/>
    <dbReference type="OrthoDB" id="4214675at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008903">
        <property type="term" value="F:hydroxypyruvate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046487">
        <property type="term" value="P:glyoxylate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.150:FF:000007">
        <property type="entry name" value="Hydroxypyruvate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026040">
        <property type="entry name" value="HyI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050417">
        <property type="entry name" value="Sugar_Epim/Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43489:SF6">
        <property type="entry name" value="HYDROXYPYRUVATE ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43489">
        <property type="entry name" value="ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006241">
        <property type="entry name" value="HyI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylose isomerase-like TIM barrel" evidence="9">
        <location>
            <begin position="13"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="8">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="8">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR006241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR006241-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAE1277583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="253" mass="28695" checksum="11CF81B5859839E5" modified="2021-09-29" version="1">MFQELPKLSDRYQAAKDAGFRYVECTFPYDEPVEVLKAAKEKAGVEQVLINSWPGDQSQGQLGLATLSSKQKEFCDKLELTIDYAKALSCKKVHIMSGKHPKVPDKATEETYLQNIEYAANRLQQEDILGLIEAVNSKISVPNYFLDNPSKAFEYVQKINHPNLKMQFDIFHVQIMNGNLTANLKNWFPAIGHIQIAQAPDRGEPHSDGEINYGYIFKLLESLQYDGFIGLEYKPTGRTTDGLTWIKQFGLQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CSQ7</accession>
    <name>A0A812CSQ7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_39987</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001879">
        <property type="protein sequence ID" value="CAE1276321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CSQ7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="315"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="356"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="402"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1276321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="430" mass="51970" checksum="4A016517C5E748E9" modified="2021-09-29" version="1">MGRRNRDDRSFPFTGVTLISFSFFLSFLSFFLFFFLSFFLSSFYFYFIVVFLSSLFHCSSFFHFNLISFFLSFFLSLFIYLFIYLFLLYLYSLSLFFHSFIYLFFIQSFIHSSLFLSFLSFFLFSLYFSQLILSFDPFSLFLYSFLFFYSFFSVHFYLIKNLLTLTFLNFLFVISFFLSFFLSFFILSFNSSFFLRFVFRSLPSLPPCLRSFFLSFFFLSFFLFSFFLSFFLFSFFKLIFFLYFFFLFLFSLLTFVFFLLLFFISLAYCSKFTSDYSCHLFTFSSLFPFLFSLFVPSLRRGKDERGNILSFSRLFLFLIFFNSFLFSLISSSLFVICFSSYYLSLFSSFFLSLRHFFLSFFLFCLAFIDLAFLIFLSLSSLLSFSSSPSSFYIFCFYFSFSYYLLLSILCIYFPLNFPFFLSLILLSHLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CU73</accession>
    <name>A0A812CU73_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_44924</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002306">
        <property type="protein sequence ID" value="CAE1284743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CU73"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="338"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1284743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="494" mass="56276" checksum="C6F4C2E5492D6288" modified="2021-09-29" version="1">MTSQSKTPRRIFTLLKLASSLLVIFLLLPGSFHSFLFLRDILSLNFWLLPVLFWLPILPLLPVLFSGFLFFRDILSQFLASSGSFPASLFFRDIPIIISASSGSFPGFLFFRDIPYHLISGSSSLTLCSFPGFLFFCDIPIHLISGFFRFLFLASFFYSLSLIFLSLSSVTGPFSGFSVISYGFLSCSFPGFLFFHDIPILNFWLLPVIFLASYSSVIFLASYSSVTSLSLISGFFRFFSGFLFLFFRSFFSGFPILRNIPIHLISGFFQFLSGFLFFPPSLFLASSAFSVSFLASYSSVTSLSLNFFASLVSFLASYSSLLWVLFLTYSSVTSLSNFFPSGCFLASYSSVLLVLFCFPILPCSPYHLISGFFRFFPGFLFFLTSLSLNFWLPSASSGYFVRFLFFEYLHVTFGRKEFIFCFLFFLEYDPYHLQEKLLWVFFSLVENSSLTSLSLISDGYSRFVFLASYSSVTSRSLEDFQFFSVSFFCWLVPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CU80</accession>
    <name>A0A812CU80_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_40302</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001902">
        <property type="protein sequence ID" value="CAE1276848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CU80"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1276848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="256" mass="30004" checksum="146DBF7BB5D9080E" modified="2021-09-29" version="1">MSLFLITSFFLSFFLSFFLSFFLSFFLPLFMCPFFYISHCQPLSLLLQLCLPYLNSIDILCIFLSVFLVQYTSPSPSLSPLSLYFFLFPLLSSTLSLPHSLSLSSSLSNPLILYFLVLLFRSLPFLFSFHFLHFFIPSFIFPFFSFIMSFSPSPPSLFPYPSPLLSLTLSFFLLLPLFLCLCLSVFLLFESIFVSLYVSFYIPDFSTPPLSRYLALLLILVSLSFLFFLFFIIHFYRIYSFLLHCFIFILSFLFFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CUC4</accession>
    <name>A0A812CUC4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_43630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002202">
        <property type="protein sequence ID" value="CAE1282734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CUC4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="232"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="329"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1282734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="378" mass="41903" checksum="6A9BE86BD724C704" modified="2021-09-29" version="1">MSFSLPFSPSLSLSLSLSLSLSLSIYLSISFSHFRRLSVSFYTCVCVFHCLCVCLPKTRFFTLYTCAFSLSLYLSIYLSIYLSITVYSYQYLSIYLSIYLSHFVCVSHTFSYSSPPLSHLGCFLSMPFSLFIYQPSHTLALSLSLSLFLFPLSLSLFVCTPVCVSMLVCVFPNLSLSLYTCALFFLLSLSLSLSLSLSLLSIYLYLSLFVCASLSLSVSISECLSVYLYLSLFMYASFSLSLILSLSLCLSIYHYSYVRLSSPLSLSLSLSLSLCISLSFSVCLSGSLSFFLSHYLSLSLSDCLSVLNLSFFMCASLSLSLFLTLSLSLFVRVCLSLSLSLTLCLSLSFFVYLSLSSFSLSFSLSPSLFHILSQSLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CUR1</accession>
    <name>A0A812CUR1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_40954</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001949">
        <property type="protein sequence ID" value="CAE1277941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CUR1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="282"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="318"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="359"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="395"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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        <location>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="935"/>
            <end position="953"/>
        </location>
    </feature>
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        <location>
            <begin position="958"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="984"/>
            <end position="1005"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1277941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1058" mass="131178" checksum="5B1AF4B1029CE276" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CVD6</accession>
    <name>A0A812CVD6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_42365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002068">
        <property type="protein sequence ID" value="CAE1280496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CVD6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="41"/>
            <end position="66"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="100"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="142"/>
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    </feature>
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            <begin position="148"/>
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            <begin position="202"/>
            <end position="225"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="318"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="330"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1280496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="382" mass="44783" checksum="DA92418C6C2AD247" modified="2021-09-29" version="1">MCRLLTLVHKFCPHMGQMTPRFLPSNPSYLRRSPAIKNTTLIFIGQFVIDTEILFSFQHLFLLSLLPSLIFLSYHHTFLLFTFLSFFALSFHFFFSDSFLPSFRLFSFRHTFSSSLSVPFSRCFLISIFLHLSFSILFSLIIPPVILSFYVFSLIISFFLSFFLSFFLSFLSSYVLSFYLFPIIPFFSLHLFSFLHSFLPVIIIYFFLSFLLSINPSFFSSIISFRHTSFFLSFFLSSPTGRHVTLVNSCHRNICDESVGVTWLVEFSECLQIYWISVCSYLSIYLSIYLSQSAHIYLSIYLSIYLSIYLSQSAHIYLSIYLSISACSYLSIYLSIYLSIYLSISGSSYLSIYHFRCIYLYMKIMIDHNVAIYLSLYERCDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CYH0</accession>
    <name>A0A812CYH0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_42609</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002090">
        <property type="protein sequence ID" value="CAE1280783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CYH0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="356"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="391"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1280783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="413" mass="48882" checksum="C69CD5AD616DDAB2" modified="2021-09-29" version="1">MSVCMTAARRRRRVYVKRTPANERWRGWASKYIHGQTHIFSLSLFLSLSFSLSLSLSRIFYLTEGRIYRSLTYVTPALRSFKIDRVGTIGFSLVHARIYDSLRSGVRRENRSRLADGRQSACRIIADVGRKIAKPHKYPPMSAVFCLFCFSFVVSFKLSPLQPPFRSSSFLHHSLSLSKFFIWRFSFFLFFVSVRVRIQSANRSLYQLIIQSEFSLQVTYSFVSIIFSLPSLVSFCFFFSFFFFIFFSNLLFLLIVFLLFLSLILFYFLFVIFLFLSFHYFFLLFLFFFFNPKVFFRLPFLLFDFHLLFCRFLLIYFQSCPYFFLPFISICFPFFSFFSFTSPYHLFVFTPLVDSLFLSFMIFLQPYFILFSLFIFSSFSTATFIINSVSFVYSFPSCKLPAAISVFFSILST</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CZI0</accession>
    <name>A0A812CZI0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SULT1A</fullName>
            <ecNumber evidence="5">2.8.2.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SPHA_43227</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Farmed</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfotransferase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.1" evidence="5"/>
    <dbReference type="EMBL" id="CAHIKZ030002157">
        <property type="protein sequence ID" value="CAE1282088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CZI0"/>
    <dbReference type="OrthoDB" id="205623at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004062">
        <property type="term" value="F:aryl sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11783">
        <property type="entry name" value="SULFOTRANSFERASE SULT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfotransferase" evidence="4">
        <location>
            <begin position="42"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAE1282088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="238" mass="28135" checksum="C785CC2389FA1A1A" modified="2021-09-29" version="1">MLLKHEYLSIYLSIAFNSLSLAFCSLSIYLSIYRILHDNFVSNEARVLNTHLPLRMLPTEILDKKIKTVLIARNLKDVAVSLYCHLKMLDEETPYEGTFSSFLDIFLDGNLSYGSWFNYMLEWQNVFDNHPDWPVHIVLYEDLIEDPAREIQKLANFLGKYSDKDFCSQIADKCHIDRLKKAKPEPNMYVKLYVRIHMLFYHTHIYLSIYLSIYLSIYLSISFSLSLSLSIYIYIYIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D1S9</accession>
    <name>A0A812D1S9_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7041 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_43678</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002207">
        <property type="protein sequence ID" value="CAE1282833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D1S9"/>
    <dbReference type="OrthoDB" id="6433758at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055469">
        <property type="entry name" value="DUF7041"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327">
        <property type="entry name" value="ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327:SF3">
        <property type="entry name" value="RNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23055">
        <property type="entry name" value="DUF7041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7041" evidence="2">
        <location>
            <begin position="7"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="167"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1282833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="270" mass="30443" checksum="7F5F37C17A63D0F0" modified="2021-09-29" version="1">MPVFNSNVQTWFLQLDAIFQARHITSQQSKFAAVVEKLPAEVAAEVADILLTSLPIEKPYETLKQAILHRSGFSEERKIRNLLNVTIGDARPSQLLRRMQQLLGDNDISTTVFRQMWLDKLSADIVRILAALADDMDIQKLATIADKVADTTPIRHISATETVDGLVPDVNRQIQKLSSELQEISIQLRDLQKSHTSRRDNSTKHNKRLGININNDEIVINTQIVGTRTLARARRNVDNLVHIGSHSRVIKRETDTLAPSRDVGCQTFKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D5A6</accession>
    <name>A0A812D5A6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_47779</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002622">
        <property type="protein sequence ID" value="CAE1289670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D5A6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1289670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="306" mass="33914" checksum="9DA298546DBB6FE2" modified="2021-09-29" version="1">MVWKLAYFNLSISLSLSLIYFSLSLSGSLSLSLSESVSLSLWICFSLSLICFFSLSLSDLFSLSLSLSDLFSLSLSLSESLFLSLSLSLSGSLFFSLSLSLFLSISLSLSLWICFSLSGSVFSLSLSDLFFLSLWICFFLSLSLSGSVFSLSLFFSLSGSVFFLSLSGSVFFSLSLSLSLSLWICFFSLSGSVFFLSLSGSVFFSLSLICVFFSLYICFLSLSLYLLFFFSLSDLFFYISLSGSVFNIFLSFYICFSSLSLFFFSLSLFFSLSLFFFSLSLFFSLSLDFLSLSVFLSLSGFCFLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D5D3</accession>
    <name>A0A812D5D3_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_47631</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002597">
        <property type="protein sequence ID" value="CAE1289376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D5D3"/>
    <dbReference type="OrthoDB" id="10068383at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33198">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33198:SF20">
        <property type="entry name" value="RETROTRANSPOSON GAG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="255"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="470"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="331"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="470"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="514"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="525"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="538"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1289376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="605" mass="69525" checksum="5CA4E9B821DAD0B5" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D5W4</accession>
    <name>A0A812D5W4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_49253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002800">
        <property type="protein sequence ID" value="CAE1292391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D5W4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="377"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="400"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1292391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="429" mass="51854" checksum="019B966600E74C30" modified="2021-09-29" version="1">MFFLSFFSLSFFSVFLFFLFISSFLIFSFFPPYSVSFFLSFFLSFFLSFFLSSPYLSFLSFFSFFLFFLPVSSFLSFLIILFLSFFLFLSFFLSLFLSLFSFFLSFFHFLFLSFFPHFSVYFFFLSFLFLLLSLPVSFLIILFLFLSFFLSFFILFSLFFLSLFLLFLLLNFFFLFFLPFLLLLFKFPFLSFFLSFFLSFFLSFLSFLLSLLLIKFLSFFLSFPYLSFLSFLFLIFLFLSFFLSFFLSFFLCCTNFTILSFLHDTSSLSLSLSLFHFSIFVATHLLMIGTFFFFFSFNSSFLSIFSFFLCSFLRFLDHFSLCFFLFSLRFFLFSLHFIFLSFFFSLHLSLFTLCQFLFLFLSLFSFLLLFSLLRLSYFFLPFLFFLSSSLFFYFRNVRSFITFFIFSSFTFSFFFFSSLFFIIISASLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D7K2</accession>
    <name>A0A812D7K2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_48369</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002687">
        <property type="protein sequence ID" value="CAE1290753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D7K2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="299"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="327"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="358"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="452"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="487"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="519"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="546"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="572"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1290753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="594" mass="68500" checksum="12282C2FFF73A257" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DEA2</accession>
    <name>A0A812DEA2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_51360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003108">
        <property type="protein sequence ID" value="CAE1296281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DEA2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1296281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="260" mass="33443" checksum="FB65ABE2C7DBF3E3" modified="2021-09-29" version="1">MFIIFFFFLFRLPIIFLSFFFQFLSFSLSFFTFFFHFLFSLSFFTFFFHFLFSLSFFTFFFHFLFSLSFFTFFFHFLFSLSFFTFFFHFLFSLSFFTFFFHFLFHFLFHFLFHFLFYFLFHFLFSFFFTFFFLSFSLSFFFLFHFLFSFFFTFFFFFFFFFFFFTFFFHFLFFNFFFTFFSFFFPFFFNFFFHFLFSLSFFTFFFHFLFSLSFFTFLIGFFCFPFSLHICDHPFFSFSLSPLSHYRSLLVTPHCSFLFVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DEH8</accession>
    <name>A0A812DEH8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_50891</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003032">
        <property type="protein sequence ID" value="CAE1295358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DEH8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34723:SF7">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34723">
        <property type="entry name" value="PROTEIN CBG17025"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="157"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="232"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="317"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="371"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="396"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="429"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1295358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="459" mass="54163" checksum="89AC6C995EF6F521" modified="2021-09-29" version="1">MEIPLGRLTSTNCRTGQWRPRRTFTTGLLCSFIHQAECISFFALSDVHYVSLILFRFISVRQKIETIGDFSGKTAFNFRFCSIQFYLSIYLSIYLSIYLSIYLSTPDLHLFISIYLGLFISTYVHIYLSRPVYIYICSYLSRPAYIYICSYLSIYLYPFNLPIRGLSFFLSFFLSFFLSLKATSGINLFFSFSFFLSFFISFHMHLIIYLSIYLSIYLSIYLSIYLSHSAHIYFSFFLSFFFLSVFNYILPPLPLCILFLFHFLFETDNRFHFTEKCNKRVIHSFLHYFLPLFFPSFLPSFLPSFLPSSLPSFLPSFLPYSFLLSFIHSFLPAFLLSFLPSFLPSFHPSFFLPFIHFPSFLHSFLPSFLPSFLPSFIHSFLPSFLPFFLPSFRHSFLPSFLFSSLPSFLPSFLPSFLPFRETLNTSIFFSLLFSSFFLSFFFLSFFLSFFLSFFLSLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DEJ6</accession>
    <name>A0A812DEJ6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_54733</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003593">
        <property type="protein sequence ID" value="CAE1302010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DEJ6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1302010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="278" mass="32409" checksum="7991A6A80D68E5F8" modified="2021-09-29" version="1">MFYSIIDNVLSLSLSLSLSLNILSLLFISIFAFSSSLSILVFVSISHCYFFISVFLFASISLCSLFILFHFSSLSLIAIFFVSIFLFSFSSYIFLFHCISPFSTFFSFFIILSVILFTPSLYISVCLEIHSKVYGGINDLLVFTNQIQLIEQIQAQRHSFLLFPHYIFFYLYLCNNLPPSITQSITQELGTDTTRTSVPHLRHDPNRNMPSQTALLTQTYFLLILFDSFLIYLHIALSFFFFVLVSVFRSIFFFFFIHFFLILHLLTRLLFFFLFLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DF95</accession>
    <name>A0A812DF95_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cytochrome oxidase subunit I profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_54726</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003583">
        <property type="protein sequence ID" value="CAE1301984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DF95"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023616">
        <property type="entry name" value="Cyt_c_oxase-like_su1_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50855">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="311"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="349"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="379"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="416"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="447"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="475"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="507"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="537"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome oxidase subunit I profile" evidence="2">
        <location>
            <begin position="27"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1301984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="555" mass="69543" checksum="D5E6918C5CE0F2B9" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DG28</accession>
    <name>A0A812DG28_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_55429</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003692">
        <property type="protein sequence ID" value="CAE1303213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DG28"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1303213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="181" mass="21261" checksum="02DA4B96DB28B5B6" modified="2021-09-29" version="1">MKTVVSSLGNSIERSAQIFSLTLYVSIIISPSVHIYLSIYLSFNLLIYLSQRIKTKPIYLSIYLSIYLSIYLFTSIYHKILINCYIYLSIYLSIYLSMFISIYHKILIAISIYLSIYLCRQLLDLSIYLSIYLSIYLTGIISIYLSIYLSIYLSIYVYKLTVFKDHNPTDKQDYFTMTFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DGR2</accession>
    <name>A0A812DGR2_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SPHA_51948</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003187">
        <property type="protein sequence ID" value="CAE1297333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DGR2"/>
    <dbReference type="OrthoDB" id="9049620at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="443"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="13"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="178"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAE1297333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="480" mass="55273" checksum="5978BB46F7AF3279" modified="2021-09-29" version="1">MASNVNDEETFQCSKCDQYLNWTSKTLPCLHSFCESCVLEGNGLCPQCQKPVTGDDLRLAPFLVKSLRRRELESSEWRCDWCFEDGMESSGQIWCHECVKLLCQNCNRGHKKSQRTHHWEDLSGKERVEAIRLITTDDCRRHRQSKDAFCQRCNVCLCDSCYKDHVTASPQCPPRPLSVREEASKGKEEGGPTLERELLQFEIQIRSTYAQTSRSIEQLTTDSESECLKLCQDFETFVKEARLKLAELCDNMKVMASELERKWRRSLKEREDLLKKVTIWRHTLRHLLTDDADDADVVCGLRLVRAELSARLHQSFAPPEKGRWLVTFPKWCHDSLDSLRKEMIEWAAETSGHLQMKSECRLQESNPLDLSSIVAGDEDSRIFVGDWSSGSIQEFSDRGEFVGQCPLTDGGKEFYPRDMCRVSKDILAVCGWQSEGFVCLCSFFLFLSFSFFFSPFSFSTFLCFFFSSFSFEESKGNNST</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DIR3</accession>
    <name>A0A812DIR3_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Shisa N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SPHA_52509</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003271">
        <property type="protein sequence ID" value="CAE1298278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DIR3"/>
    <dbReference type="OrthoDB" id="6158295at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053891">
        <property type="entry name" value="Shisa_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13908">
        <property type="entry name" value="Shisa_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Shisa N-terminal" evidence="3">
        <location>
            <begin position="13"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAE1298278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="223" mass="24209" checksum="7385646F44052278" modified="2021-09-29" version="1">MYYDHPYRKPTICSNYIDSDENGTIYQMFICPRHYEMDSFAYCCGPSERQTCCKSPNRSGSVIGAIIGAILLVAIIGAIIYCVCRHNKKRRGEVLSKNNEPIGTVLVPPPQQMPPPGMGPVPPQPMGYGTQPSPMMGYGPDPNQAGFPVNYGAAYGQQPYMPPQGYPQHPLPGQNYPPAYGQPDLSQPPYPSAPSYPGQVPPPPGFNMPGPVPSQPPPPYPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DIZ6</accession>
    <name>A0A812DIZ6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_57624</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003891">
        <property type="protein sequence ID" value="CAE1305129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DIZ6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="327"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="362"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="391"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="422"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="451"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="485"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="514"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="548"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="583"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="611"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="635"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="660"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="692"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="720"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="753"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="799"/>
            <end position="816"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1305129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="817" mass="98477" checksum="4F7A5CA6CE87506B" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DJG9</accession>
    <name>A0A812DJG9_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methionine adenosyltransferase 2 subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Methionine adenosyltransferase II beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SPHA_54798</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Farmed</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine. Can bind NADP (in vitro).</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterotrimer; composed of a catalytic MAT2A homodimer that binds one regulatory MAT2B chain. Heterohexamer; composed of a central, catalytic MAT2A homotetramer flanked on either side by a regulatory MAT2B chain. NADP binding increases the affinity for MAT2A.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dTDP-4-dehydrorhamnose reductase family. MAT2B subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003603">
        <property type="protein sequence ID" value="CAE1302108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DJG9"/>
    <dbReference type="OrthoDB" id="6235964at2759"/>
    <dbReference type="UniPathway" id="UPA00315">
        <property type="reaction ID" value="UER00080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05254">
        <property type="entry name" value="dTDP_HR_like_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005913">
        <property type="entry name" value="dTDP_dehydrorham_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029903">
        <property type="entry name" value="RmlD-like-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10491">
        <property type="entry name" value="DTDP-4-DEHYDRORHAMNOSE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10491:SF4">
        <property type="entry name" value="METHIONINE ADENOSYLTRANSFERASE 2 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04321">
        <property type="entry name" value="RmlD_sub_bind"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="9">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="RmlD-like substrate binding" evidence="8">
        <location>
            <begin position="140"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="RmlD-like substrate binding" evidence="8">
        <location>
            <begin position="324"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="88"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="111"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00045998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00046786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAE1302108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="429" mass="45902" checksum="4C65DE9940D07487" modified="2021-09-29" version="1">MIAKALDGEALPIYGKGDQVRDWLYVEDHVRALQAVFERGEPGRTYNVGGHNERQNIEVVKTLCAILDELRPRADGKPYAAQMTEVADRPGHDSAMRSTPAASAPNWAGPRPRRSRPAFARRRPSGAAWRHDGGYPPCAILVTGAGGQLGTELQRCARRRAEIVAIDHDTLDLRDTTAIAAMVASRPFAAVINGAAYTAVDKAESDVVTARAVNAMAPAAFGEACAKAGIPLVQVDRLCVRRRQARRVEVNDPVTPLGVYGASKLGGELAVRTSGARHAIVRTAPGRVRAWPQLHQDDAAPGGKPRHAVGSCRPAWLADQRCRPANALMTIALRLIEDEAAPTGTFHFSNAGAISWADFATEIFRQSDARGGPSAAVVPIPSSDYPTPAARPANSLLSHSAIHAAYDIAPRDWQMALSDILDELIGATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DLL3</accession>
    <name>A0A812DLL3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_57236</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003855">
        <property type="protein sequence ID" value="CAE1304680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DLL3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="246"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="283"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1304680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="351" mass="38288" checksum="47BAA580A0E196BE" modified="2021-09-29" version="1">MDDARPVADRQSCHRARADSAASVVVDRPLDRQPPYRPPRGSRCARPPARDAARAKAHAQRPQKGAAPHDVARRSNRSPDRGIAGEGGSFQPVLHAQPHHDPRQQRAGNQFTQLGDILRCIGVRQAQPGQCPLCAQLAGFLGDRTRQVTRSALLSAACASSRARTSPLATSRPWRASRRIESARAYLPQHLALLGQCGDAVDVDRQARPFEPTRESLQRPLRIPSGRIACPPKRGSPRGNWRQILSPGSPSSIGGTPRPARDLARRRRLAAMKSSSSGRQAHRLPLARLRAAMDAPHCRCPQSPPSPARSQFGTGQGSGVEPSPDHIDQRPRWPAPHCRAAPGSVRWRPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DLZ8</accession>
    <name>A0A812DLZ8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_58822</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004049">
        <property type="protein sequence ID" value="CAE1306604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DLZ8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="297"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="327"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="360"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="384"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="424"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="450"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="487"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="518"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="578"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="604"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="632"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="654"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="686"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="712"/>
            <end position="735"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1306604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="738" mass="88570" checksum="AB5DE4B047AB00FA" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DPT7</accession>
    <name>A0A812DPT7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_57645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003891">
        <property type="protein sequence ID" value="CAE1305114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DPT7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1305114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="171" mass="19247" checksum="98C89A132B6DB405" modified="2021-09-29" version="1">MNTSPTRIISRLNNTTAIDTACLSLSLSLSVCLSHFSLFFSLFSLFFSLYSLSLLSLSSFSSLSILSFLSLFYLFFSLSSLFFLSLLFLFSLSILTFLSFFFSFFFLSLFSLFSLSLFFSFSLFSLFLSLLSLFSLSLLSLSSLSFSVVGISIYLSIYLSIYLSISIYLPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DQE3</accession>
    <name>A0A812DQE3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_57884</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003920">
        <property type="protein sequence ID" value="CAE1305461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DQE3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1305461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="312" mass="36817" checksum="278B07179FC29B66" modified="2021-09-29" version="1">MASAPPCDLHQTDAVFLSASLPFPPYLLLLPPIPFSFLPFTWLLFPSPLLLLCSKAFSLQCNRLIQQQLPQNLPEDYFYSCYLLFLLGFDISFLSSLLPLPALFICHFSFNCCSYSLFLKCAFAMSLFYGRFLHFFSLIQSLLLSPSHSLVSILFLLFFLSNFTTLSFLFLYPSFSIHHFSIFICSPSLYYHLSTSFSSFTFSLFIIIYHSPSLSYFPYFLFNFYSLSFYFLSSFFFYLILLSTFSPSIFLFSFLSFLILSPLAFGFFFFFFFFFFFFFFFFFCCCCCFTLSFTFYFFFLFPFFSILYLFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DR70</accession>
    <name>A0A812DR70_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_57103</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003831">
        <property type="protein sequence ID" value="CAE1304508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DR70"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1304508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="171" mass="20041" checksum="418497378FED00B3" modified="2021-09-29" version="1">MSSLRRPHFLSFQTFSLSIHVNLYRFSSSSHILHGYILLSFCSSLALIWSLRFHPLTCLVFSYNRNLSFSLFLSLTFLSYFLSLYFSLSIFLTLFLFLALFYLFSISLSFTLSFLLSLYVSFSLSLSLVLSLFLLLFLSFSFSFYFLSFFLCLFLFSLSFSLSLFFFLSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DTN6</accession>
    <name>A0A812DTN6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">SLC17A5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SPHA_60570</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004214">
        <property type="protein sequence ID" value="CAE1308715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DTN6"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17318">
        <property type="entry name" value="MFS_SLC17"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Putative inorganic phosphate cotransporter-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000003">
        <property type="entry name" value="Solute carrier family 17 member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF399">
        <property type="entry name" value="FI19708P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0769">Symport</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="277"/>
            <end position="295"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="301"/>
            <end position="318"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="359"/>
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    <feature type="transmembrane region" description="Helical" evidence="7">
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        <location>
            <begin position="188"/>
            <end position="624"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAE1308715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="665" mass="74086" checksum="8DD88DE689B2ADE5" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DV37</accession>
    <name>A0A812DV37_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_59666</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004126">
        <property type="protein sequence ID" value="CAE1307617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DV37"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="309"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1307617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="332" mass="37754" checksum="42557BDAD56DBA5A" modified="2021-09-29" version="1">MLQFSPVCPTKHPFHLKTSIFFSLSSQFSLFHLSLSFVPSFFFSLSLSFIFYISSRSFFHLSCFLHFSLSLFSSFTLLFHHSFSLSLSFIFYISSRSFFHLSCFLHFSLSLFSSFTLLFHHSFSLSLFHFLHLFQVFLFNSPVSFIFLSLYFPLSLFCSIILFLSFSLSFSTSLPGLSFNSPVSFIFLSLYFPLSLFCSIILFLSLSLSFSTSLPGLSFNSPVSFIFLSLFSSFLFCSIILFLSLSLSFSTSLPGLSFNSPVSFIFLSLYFPLSLFCSIILFLSLSLSFSTSLPGLSFTSPVSFIFLSLYFPLSLFCYIILSLSLILFMCLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DVL1</accession>
    <name>A0A812DVL1_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ornithine aminotransferase</fullName>
            <ecNumber evidence="4">2.6.1.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Ornithine--oxo-acid aminotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SPHA_63277</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Farmed</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-ornithine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.13" evidence="4"/>
    <dbReference type="EMBL" id="CAHIKZ030004539">
        <property type="protein sequence ID" value="CAE1311991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="425114at2759"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00358"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004587">
        <property type="term" value="F:ornithine aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019544">
        <property type="term" value="P:L-arginine catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010121">
        <property type="term" value="P:L-arginine catabolic process to proline via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000011">
        <property type="entry name" value="Ornithine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000152">
        <property type="entry name" value="Ornithine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050103">
        <property type="entry name" value="Class-III_PLP-dep_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010164">
        <property type="entry name" value="Orn_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01885">
        <property type="entry name" value="Orn_aminotrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986">
        <property type="entry name" value="AMINOTRANSFERASE CLASS III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986:SF18">
        <property type="entry name" value="ORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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    <feature type="transmembrane region" description="Helical" evidence="9">
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    <feature type="transmembrane region" description="Helical" evidence="9">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="944"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="971"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1005"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1032"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1068"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1100"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1133"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1174"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1201"/>
            <end position="1220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAE1311991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1739" mass="194501" checksum="2284362FAFE47536" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DX45</accession>
    <name>A0A812DX45_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_60111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004157">
        <property type="protein sequence ID" value="CAE1308196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DX45"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1308196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="231" mass="28456" checksum="59E6396A74D29567" modified="2021-09-29" version="1">MIFYLPAISLPFVFYPELAFPNFPSSFIFNTQFSFLLYYLLFCWLPFIYSVYFFYFIFDIYVLSFFFILSSFSFFPIYCVSYLLFHCHFSFFYLHTLSFFPFFYLHTLSFFLSFIFILFLFFFLLSSYSSIFLSFIFIHFPFFFLLSSDSSICLSFIFRLFPFFLSFIFILFPFFLSFIFILLPFFLNSLHIFRRAYCFSYLQFYFSSSCVFFLAFFFRHKLMYLILSCLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E0R8</accession>
    <name>A0A812E0R8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_62240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004433">
        <property type="protein sequence ID" value="CAE1310709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E0R8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1310709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="256" mass="30794" checksum="B2D1F77D2177B72E" modified="2021-09-29" version="1">MTRSHSVFLPLPFKDERQNRFSLCKYRRMNSRTEHARVPLLIHHFLLSSFELVAVEVGSLAESLDHLLSIEFLAEALSRYPSFHRDLWLSLWITFFPSEFLAEALSRYPSFYRDLWLSLWITFFPSEFLAVALSRYPSFHRDLWLSLWITFFPSEFLAEALSRYPSFHRDLWLSLWITFFPSEFLAEALSRYPSFYRDLWLSLWITFFPSEFLAEALSRYPSFHRDLWLSLWITFFPSEFWLRLFLDTLLSIGIFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E1M0</accession>
    <name>A0A812E1M0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_66211</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004771">
        <property type="protein sequence ID" value="CAE1315268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E1M0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1315268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="277" mass="32089" checksum="E085AECA73D5493E" modified="2021-09-29" version="1">MIAIASFLSFFLSFFLSFFLSFFLSFSFNYHLCCVLSIRVAVPVLGKKKNLISIFSLAPRKMILEKDRKYLGNENKRNLNSYSTFLPSFNINARKVILLFIPVLHFLQFYSVGKNPTDAEYSRLNQISTVFSSTISLYLSIYLSIYLSIYIYICMYVCVNGKKKRFIQALSPPVLVLLQTHFFLLIHRLSKQVITNNNPPDTVTVQFVRMTVRRSLSPGEYSVYSPNSLSCLSSFSFLFRVSCIRFVLAAEFISAWLQLSIYLSIYLSIYLSIYHRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E4P0</accession>
    <name>A0A812E4P0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_64281</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004626">
        <property type="protein sequence ID" value="CAE1313157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E4P0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1313157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="185" mass="21787" checksum="8060C555CC210E3C" modified="2021-09-29" version="1">MVRYANRPRYANRPIHRWLDTRTDRSRQMVPQMVRYANRPIHRWLDTRTDRTDRYANRPTDDWGCGNRRVLLHLQVKHSGESDGGSSYSYLNNEGKEKKHILQDRFMRYGFLNQILRVSVQIGLSLSFSLYMYLLSGFSRPLPSSFLTSCLHFCFLCACLFLFITISNPLIYLSPLFHPSVLVFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E646</accession>
    <name>A0A812E646_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_67809</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004911">
        <property type="protein sequence ID" value="CAE1317204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E646"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="398"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1317204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="751" mass="79098" checksum="1F9035A209520206" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E8P3</accession>
    <name>A0A812E8P3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_66769</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004818">
        <property type="protein sequence ID" value="CAE1315935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E8P3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1315935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="211" mass="25600" checksum="93E64E66A8CD8371" modified="2021-09-29" version="1">MVYNLNRLLFLFFLSHFFTSLLLILYFSLFFLFFSFLRSFFLSFHLFFFLFPSFFLSFFLSSSFYSSTISILLLHPYFSFSFFFPFSFFPSFFLSFFLSFFLSFFSRDHSIHSHLFLSFFLSFFSLDHSIHSHLFLSFFLSFFLSFFHSFFSLDHSIHSHLFLSFFLSSPVIIRFTLISFFLSFFLSFFSRDHSIHSHLFLSFFLSFPVII</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E9X7</accession>
    <name>A0A812E9X7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_69865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005106">
        <property type="protein sequence ID" value="CAE1319439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E9X7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1319439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="327" mass="38228" checksum="63FDC77D080C7994" modified="2021-09-29" version="1">MQEQTFGILISIYLSIYLSIYLSIYLSLCDFISIYLSIYLSIYLSIIYLSISLSISIGSDVLKLYLLLISITIYLSIYLSIYISIYLSIYHNLLLSIYLASYYMIFTIYDSHYHSLYSNLSIYLSISLSSLYIILIMYHSLYSNLSIYLSIYLSQSFAIYLSFSIFKSIYLSISLSSLYIILIMYHSLYSNLSIYLSIYLSIYLSQSFAIYLSFSIFKSIYLSIYLSIYLSIYLSNSLHIYHNLLSVCLSIYLSIYLSISFYSNLSMFIYLSIILFISRSHSLFLSFSLSPSVYLSVEGPSFGLNYNRRPRKRVEFYEFFAGNRLHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EBA3</accession>
    <name>A0A812EBA3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_70242</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005136">
        <property type="protein sequence ID" value="CAE1319941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EBA3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1319941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="331" mass="39286" checksum="D894420208DC88AF" modified="2021-09-29" version="1">MINDVLNLSLFFLSFFLSFFLSFFHSLFITYPISLISIYLSIYLSIYLSISLQIYQPLLFLYLSIYLSIYLYLSLSIYLSIYLFAYLPTSLIYLSIYLSIYLSIYLSIYLSIYLFAYLPTPLIFISIYLSIYLSIYLSIYLSIYLSLCISTNPSHFHYLSIYLSIYLSIYLSISLHIYQPLLFSLSIYLSIYLSIYLSIYLSISLHIYQPLLFSLSIYLSIYLSIYLSIYLSMTTCVYIYLSIYLSIYLSIYLFENLYDLFYQPNIKPCLVLWYTDIFIIIIIIFSFFFLLLFFFFFFFSFFFLLFLLLLLHSVSFSSSFLHPPPSLSSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ECN8</accession>
    <name>A0A812ECN8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_68837</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005028">
        <property type="protein sequence ID" value="CAE1318369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ECN8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1318369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="281" mass="33015" checksum="04D5D8B5197E88B8" modified="2021-09-29" version="1">MSFFPSFLYKLFVSIIPSFFVAFVLCYSILFSFFLSLFHSFFLSFFFLSFLPTLSFFFFNHLLPIYGIILNFHSLFLSFDFFFIKFFMFFFHFSEFFVFPFFLSFFLSFFLSFFLANSFFQFFFHFLFLLLLLLLLLLFWGCVLSGGLSPFFFSLSLLLFLHNLALSSTDSLPPELSSTECTRRALESLRLITSSLSFRTCIQSVTLHIRLTASSFSAHSSALSNRPRATRGLHFVAILFIFVFILSSFFPAFFFFFCLLTGKISSFSLFLIHFRNILFDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EEQ6</accession>
    <name>A0A812EEQ6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_69909</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005110">
        <property type="protein sequence ID" value="CAE1319541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EEQ6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="341"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="373"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="409"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1319541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="433" mass="50213" checksum="C99C837393747EB9" modified="2021-09-29" version="1">MEVYGRFLYSLTPTNLCTPLLLPICVLLYSYQFVYSLTPTNLCTPLLLPICLLPYSYQFVYSLTPTNLCTPLLLPICVLPYSYQFVYSLTPTNLCTPLLLPICVLPYSYQFVYSLTPTNLCTSLLLPICVLLPICASLRLPICVLLTPYQFSYSLLPTNLFYSLTPTNLTASLLLPICVLPYLPTNLFTPLLLPICIVFVPLFISIYLSIYLSIYLSIYLNKKKYKTLNAFFFFSSSSSSSSSSSSSSSSSSSYFGIFPSLDNMNVSSSFHASFFFFFRFSYCRFLLQHHLFPSFFIIIFFFVFFFFFFFLFFSSFHLPFYNIYFSSFPSSSSYFCFFASPFYNIFSLLLSHFFFFLFLLLLFLLLRIFVYSLLLSITFIIFLLLFLLLLLLLLLLLRILVYFASSSHVSFSSSCFHIVDSYFYIMYFHSFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EHT6</accession>
    <name>A0A812EHT6_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heme-copper oxidase subunit III family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_73414</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005377">
        <property type="protein sequence ID" value="CAE1323519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EHT6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000298">
        <property type="entry name" value="Cyt_c_oxidase-like_su3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50253">
        <property type="entry name" value="COX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="321"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="349"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="409"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="436"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Heme-copper oxidase subunit III family profile" evidence="2">
        <location>
            <begin position="15"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1323519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="474" mass="60794" checksum="DEE46DD6EE6AE1DC" modified="2021-09-29" version="1">MALSQKRHPNIEIKKKNFFFLILFIFFFFFFYLKFFSTFSSFSIYFFSFSSIFFIFIYFLHFFFIYFFLHFLSIFFIFFIFFIFYLFSSFFLFIYFLHFLHFLFSFHFLSIFFIFFIFLSFFFLLHFLHLFSSFSIYFFHFLFFSSIFFIFFFFIFFFIFYLFSSFSIYFLHFLSIFFIFYLFSSFSIYFLHFLSIFFIFYLFSSFSIYFLFSLFSFSIYFLHFLSIFFIFYLFSSFSIYFLHFLSIFFSFFSFSIYFLHFLSIFFIFFIFFFFIFSFSIFYFLFYLFFFIFYFFIFISFFFIFIYFLHFLYFLFLHFLHFFFFFSFSLFLHFLFSSFFYLFSSFSISIFFIFYLFFYSFSIYFLHFLSIFFIFYLFSSFSIYFLHFLSIFFFLHFFIFYLFSSFSIYFSFFIYFFFIFYLFSSFSIYFLHFLFSIFFIFYLFSSFSIYFLHFLSIFFSVLNIKGLNKFLKKFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EJU3</accession>
    <name>A0A812EJU3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_72182</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005300">
        <property type="protein sequence ID" value="CAE1322186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EJU3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="299"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="337"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="376"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="439"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1322186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="457" mass="54631" checksum="20ECBC59150AD25F" modified="2021-09-29" version="1">MRNYCKTVIGDESHIAKYLSIYLSIYLSIYLSIYVSKFVNFLPSSLFFYLSIYLSILPFFFFYSYLSIYLSIYLSIYIYLSIYIHCFLFSLFIHIYLSIYLSIYLSIYLSIYLSLSIAFHPLFFLLIYLSIYLSIYLSIYLSIHLSIYVHALFFIFLSIYLSIYLSIYLSIYLFPLPSTFFFFFISIYLSIYLSIYLSIYLSIYLSKFVHCLPSSLFSSYLSIYLSIYLSIYLSIYLCPLPSYLSFFIHIYLSIYLSIYLSIYLSMSTAFLPFSFYSYLSIYLSIYLSIYLSIYLSMSIAFHLSFFIHIYLSIYLSIYLSIYLSIYLSKFAHCLPSFLFLFLSIYLSLSIYLSIYLFFFLSIYFFIYSYLSIYLSIYPFYFLSIYLFIHLSIFSFYLFCPLPSILSFFYSYLSIYLSIYLSIYLSIYHSVTVPCLPDCLSVYLCIYLSIYISIFHKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EKE7</accession>
    <name>A0A812EKE7_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Coiled-coil domain-containing protein 112</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_77165</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005506">
        <property type="protein sequence ID" value="CAE1327722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EKE7"/>
    <dbReference type="OrthoDB" id="2152435at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039902">
        <property type="entry name" value="CCDC148/CCDC112"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21549:SF0">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21549">
        <property type="entry name" value="MUTATED IN BLADDER CANCER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="106"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="299"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="411"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1327722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="482" mass="57529" checksum="1312038E434E8B14" modified="2021-09-29" version="1">MASESHEAIQQWREKVEESKKAELKKELRKLCTQYQAIQRDRDALLFSRKCSFRKEFLPLEEEEKKLNEDLKVEKTRLNHHLTKIKDMVARFRKELNNVRPSPEFVIKLKEIMEEAETEINEFKENQRKHFEVLIKEEKSAFLEIQALEKKYETWSKVEQQVQGTQPVSTGTKKPLSSARDVTVDLPPEVANFDKFVQQNGGLCGGWDVYDHETFLKFYVRYKQKAVFLSHVVPALPGKSEDDVYVHIDWYEHYLDLNEAKKEAIQKWRKSKLEEKKQKLNSPEEKWDAQEKAKQTDIQKKLEKEREEKLIQLKKWKMEQAEKKGIKEEQKLQEKMAEERKKEKEMKKMLEIREYVKKYKEAKEEKAVVMKQQKEMEEMMEMEAKRKLAAITLPKFREMDRHKMMVKALKEKCKEDIAKQKEKRLENLKKQVEVVVQRDPNRLYQPTAGWKERLKDNTTNNAGGPLLHMPHRAIPSWRVGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EL43</accession>
    <name>A0A812EL43_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_76548</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005493">
        <property type="protein sequence ID" value="CAE1327032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EL43"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="338"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="383"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="417"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="485"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="520"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="557"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="584"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="615"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="684"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="709"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="745"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="778"/>
            <end position="802"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1327032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="835" mass="92545" checksum="A2DFFEBA74C019CF" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EL74</accession>
    <name>A0A812EL74_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_75651</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005468">
        <property type="protein sequence ID" value="CAE1326096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EL74"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1326096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="161" mass="19064" checksum="37EBA30971F60B26" modified="2021-09-29" version="1">MHISIYLSIYLYLSIYLSIYLSSLLLSLSLSIYIYIYIYIYIYMKKYIEPVATVAENAAVNRSVESVVRSARFSDQYLRKSLRLNSRIGLVRLNCDQESEFRMRCRTQNISIVRSRTTVRLHVVNIRHFFTRHSRLRRRQNTWSSVAATEKPDADTFSFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EMR8</accession>
    <name>A0A812EMR8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RP-L7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SPHA_76056</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Farmed</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005479">
        <property type="protein sequence ID" value="CAE1326469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EMR8"/>
    <dbReference type="OrthoDB" id="250175at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.10:FF:000001">
        <property type="entry name" value="50S ribosomal protein L7/L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.710">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00368">
        <property type="entry name" value="Ribosomal_bL12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000206">
        <property type="entry name" value="Ribosomal_bL12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013823">
        <property type="entry name" value="Ribosomal_bL12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_bL12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008932">
        <property type="entry name" value="Ribosomal_bL12_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036235">
        <property type="entry name" value="Ribosomal_bL12_oligo_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL12M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00542">
        <property type="entry name" value="Ribosomal_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16320">
        <property type="entry name" value="Ribosomal_L12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="ClpS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48300">
        <property type="entry name" value="Ribosomal protein L7/12, oligomerisation (N-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein bL12 oligomerization" evidence="5">
        <location>
            <begin position="68"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein bL12 C-terminal" evidence="4">
        <location>
            <begin position="130"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAE1326469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="198" mass="21818" checksum="234AF693A4CF77F8" modified="2021-09-29" version="1">MFCSQLISFLTRRSVHCKRRTCLYTARLLANKNQNQESAMFSTSLVFCSEAPLAAPHIQGTEKIYAPKIQKLVDEIGTLTLLEVADLNELLKKTLNIQEAPMMAMAPAATSVKEEESTEATAPKEEQTLFTVKLIKFNAAKKVALIKEIKNQISGLNLVQAKKFVESAPQPVKTDISKEAAEQLKNALEAVGAEIVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ENH0</accession>
    <name>A0A812ENH0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_79028</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005555">
        <property type="protein sequence ID" value="CAE1329556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ENH0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1329556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="263" mass="29804" checksum="9B66D77F225BE51E" modified="2021-09-29" version="1">MIIYLSIYLSIYLLFFFSVSFSLFPPSVSLFINTDMHLSTKGDNSLFSCILGSATEALVIFFVKFRITSLHYLSIYLSIYLSIYLSIYLSQSVHYLFIYLSFYLFFFFFLSISPQARREATTFSLSLSLSLSFSLSLAHSISISLSRILNLNLSLSLSLSHTQSQFLSLFLSLSRTLNLNLSLSLSLSLSYTQSQSLSLFLLSRTISISLFLSLSLTLNLSLSLFLSLSHTQSQSLSLSLSLSHVFRSIYLSIYLSIYLSIYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EPP1</accession>
    <name>A0A812EPP1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_79956</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005584">
        <property type="protein sequence ID" value="CAE1330685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EPP1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1330685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="266" mass="31989" checksum="07E1CCBE35D5A2FC" modified="2021-09-29" version="1">MHPRSFFFFSLYVCLSCCLLPSLSYSIFLFVCLSVCCSLSLSFSLSLSLSLSLSLSEIHTNIDFIKTRKCFFFFHCLSLSFMSYFLLSLVSLLNIFFSFFLFFSLSIESVYRIALFLTFFFFHFIFFLYFSFLSKESVQKNVFLFLQSYFFKGYAKFSFTLLFAFFLFSFSFFPFSFFPSFPFFYFLSIRLCFFLPLSYFLSFFRFLSFFFLSHFFLFLSFLLFLSFNFFLSVFLSFFLFLTLLLSFYPAQIESDDKIQFNFSFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EQ11</accession>
    <name>A0A812EQ11_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_78865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005552">
        <property type="protein sequence ID" value="CAE1329316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EQ11"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1329316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="224" mass="25290" checksum="40518ECAE6B631CB" modified="2021-09-29" version="1">MFFSLPICLSLTLPLYLTDSRFCLSLPSYSCLQLQLFYFTVSVFVSLPIRLSLAILFTDSLFVSLTLFLSMSLSLSSTPPFPTFLLFLFKPLSLFSYPSLCLPVAPSLPLFLLILCLSLFLSVSLSSSPSFPLFFTVSFFVSLTFFFSVSLFSTRPLPPNIFTDSLFVSLPILLSLFRSLLLFFTHSLFVVLTLFLSISLSLSHLLFFSSTLFYLPFFHFLSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EQ89</accession>
    <name>A0A812EQ89_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_80023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005588">
        <property type="protein sequence ID" value="CAE1330767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EQ89"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="367"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="399"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="433"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="458"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="485"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1330767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="501" mass="60780" checksum="7B93590D8E32700B" modified="2021-09-29" version="1">MLIVLLCSQARVLKTFCSLTFLHDTLFYFILLFIISFSFSFFSPTLCLLFCLSLFILLTLIITRFICFIIFPFFYFLSLPISLSFTSSLFLLFFLLFPHFSYYTFFYFLSFSAILSFISSLFLFFFYFLSLPIILSFTSSLLLLLFLLHPVLFYYYFFYFLSFSINFTFTSSLFLLIFLLLPLSSYYSFFYFLSLTIIFLLHPVLFYYYFFYFLSFSIIFLLFPLSSYYAFTFSLSLSLSLYYSFFYFLSLPIILSFTSSLFLLFFLLFPLSSYYSFFYFLSLPIILSFTSSLFLLFFLLLPHFSYYTFFYFLSFSAILSFISSLFLFFFFTSSLSYYSFFYFSLYYYSFFLHPVLFYYYFFYFLSFSINFSFTSSLFLLFFLLLPLSYYYLSFTSCPFLLLFLLFPLFFYYFSFISSLFLLFFYFLSLSLSIILSFTSSLFLLFFLLLPLSYYYSFFYILSFSIIFSFISSLFLLFFYFLSLPLYYSFFYFLTFPIILFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ETB6</accession>
    <name>A0A812ETB6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_77100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005504">
        <property type="protein sequence ID" value="CAE1327656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ETB6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1327656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="311" mass="36712" checksum="CD586F0E02EDC9FB" modified="2021-09-29" version="1">MFHLSIYLSIYLSIYLYILFISIYLSLFLSLYLSLLISIYLSLLISIYLSIYLSIYVNYLSLFISIYLSIYLSIYICSILFIIISVCSCLSIYLIYLSQSIHIYVSQFAHFYLSQFINIYLSIYLSIYVNYLSLFISIYLSIYLSIYLSIYISIYFAHFYLSQFINIYLSIYLSIYVNYLSLLISIYLSIYLSIYLYIYICSILFIIISVCSCLSIYLIYLSQSIHIYVSQFAHFYLSHLLISIYLSIYLSIYLSICRLIYRKINQTNLSHSIYFSIPLSPSPSLYLSLSIYLSIYLSIYLSIYLSFSISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EV95</accession>
    <name>A0A812EV95_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CYP4V2</fullName>
            <ecNumber evidence="8">1.14.14.79</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SPHA_79281</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Farmed</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.79" evidence="8"/>
    <dbReference type="EMBL" id="CAHIKZ030005564">
        <property type="protein sequence ID" value="CAE1329935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EV95"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF189">
        <property type="entry name" value="CYTOCHROME P450 4C3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="533"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="599"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="483"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAE1329935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="632" mass="74415" checksum="6CD5F11CB4843C6F" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EW14</accession>
    <name>A0A812EW14_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_79714</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005575">
        <property type="protein sequence ID" value="CAE1330391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EW14"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1330391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="261" mass="30287" checksum="0D27DEE3A3C03F85" modified="2021-09-29" version="1">MHAHLSIYLSIYLSISVGSYLSIYLSIYLSIYLSISVGSYLSIYLFRSVHIYLSIYLSIYLSIYLLTDLTFFARLTLFVCLTVFDRLTVFVCLCPSLSGSVRLTLFVRLTVFVCFCPSNPLFSSNRQCPFKRHFSSDRHCLYYCICFCPSNRHFLSKRLCPSNSFCLSFYSYPFLSVSLFFVRLNIIVRLIVFFRFYPPNSVRHCPSNRLCPSDSLCATMFVNENSDTKETSWAAKSKSTIVHSPIRSDAYMTRRLVIRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AL50</accession>
    <name>A0A812AL50_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000025">
        <property type="protein sequence ID" value="CAE1141680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AL50"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1141680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="218" mass="25127" checksum="3D68BA09F7E2A09B" modified="2021-09-29" version="1">MILSLSLSLSLSHFSLPFFVAHTPKGCLDLFDFLSTFPLLFGDLHLSHDFFHSPAFYRLLIFSLAAFFFRGLLSVSFAFFYAFPRSSSQRRFSPPPPPPPAAAFFNLAFLSILFSSTVRLFCYSHCKRVRFSTITFLSPFLSSFFLILCDLFLLLFLFSNVSQFHSFILTFSFIFFLCNKIGQAHWSDNFLLSVFFNSPTRQFLLGTIPYRFIPIPSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ALL2</accession>
    <name>A0A812ALL2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_389</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000006">
        <property type="protein sequence ID" value="CAE1139388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ALL2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1139388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="219" mass="25557" checksum="98D698A6DFC7F7D6" modified="2021-09-29" version="1">MNGQVRYHAGVATQRAYTILSFSYEHPINTATRQGSTSCLLSDKEEYAHDEQYPYSRRKLSTVSSHCFNPFMLSSVKEIRLFIDTCKEVFSSFLSLSITFHCLVILNYNLSNNLSIHSYQCLFLSLTLFQSIYLSIYLSIYLSIYLSITCYFTNFGHHFCVKQNFHFIRSFIFSSIHIYLSISVYSYLSIYLSLFISIYLSIYLSIYLSIYLSISIYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ANK0</accession>
    <name>A0A812ANK0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_1786</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000051">
        <property type="protein sequence ID" value="CAE1146263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ANK0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032869289" evidence="2">
        <location>
            <begin position="17"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1146263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="306" mass="35685" checksum="790DC9716861CD1A" modified="2021-09-29" version="1">MLFLTLSLLQASLSHSLCFNNLCCSLTLSLSLLFTFFLSIYLSIYLSIIVCLYLSLFTCMYVSISVYFYLSIYLSIYLSKSIRIYLSIYFYLSLFISIYLSISIECIHIYLSIYLSIYLSIYLSIYHSLLLLSIYLSIYLSIYLFLSKSIYIYLSIYFYRSLIISICLFLSIYLSVFISIYLSIYLSIYLSIYHSLFISHLLLSIYLSIYLSIYLSIYLSIYSHIHLLINVKLFFASYPILLFFWWMAFFFFSFLLHSSSSSSSSSFSSSSPDASFSISFFLSFFLSFFLSFFLSDTSVSALPKGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ASF2</accession>
    <name>A0A812ASF2_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Peroxisomal trans-2-enoyl-CoA reductase</fullName>
            <ecNumber evidence="13">1.3.1.38</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">SPHA_5923</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">Farmed</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Participates in chain elongation of fatty acids. Catalyzes the reduction of trans-2-enoyl-CoAs of varying chain lengths from 6:1 to 16:1, having maximum activity with 10:1 CoA. Has no 2,4-dienoyl-CoA reductase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>(2E)-decenoyl-CoA + NADPH + H(+) = decanoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:44960"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:61406"/>
            <dbReference type="ChEBI" id="CHEBI:61430"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:44961"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>(2E)-dodecenoyl-CoA + NADPH + H(+) = dodecanoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:44964"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57330"/>
            <dbReference type="ChEBI" id="CHEBI:57375"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:44965"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>(2E)-hexenoyl-CoA + NADPH + H(+) = hexanoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:44956"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:62077"/>
            <dbReference type="ChEBI" id="CHEBI:62620"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:44957"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>(2E)-octenoyl-CoA + NADPH + H(+) = octanoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:44952"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57386"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:62242"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:44953"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(2E)-tetradecenoyl-CoA + NADPH + H(+) = tetradecanoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:44968"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:61405"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:44969"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a (2E)-enoyl-CoA + NADPH + H(+) = a 2,3-saturated acyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:33763"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="ChEBI" id="CHEBI:65111"/>
            <dbReference type="EC" id="1.3.1.38"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:33764"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Interacts with PEX5, probably required to target it into peroxisomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.38" evidence="13"/>
    <dbReference type="EMBL" id="CAHIKZ030000195">
        <property type="protein sequence ID" value="CAE1159361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ASF2"/>
    <dbReference type="OrthoDB" id="417891at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019166">
        <property type="term" value="F:trans-2-enoyl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033306">
        <property type="term" value="P:phytol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05369">
        <property type="entry name" value="TER_DECR_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000335">
        <property type="entry name" value="Peroxisomal trans-2-enoyl-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052388">
        <property type="entry name" value="Peroxisomal_t2-enoyl-CoA_red"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24317">
        <property type="entry name" value="PEROXISOMAL TRANS-2-ENOYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24317:SF7">
        <property type="entry name" value="PEROXISOMAL TRANS-2-ENOYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="21" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7 22" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="21" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00041063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="CAE1159361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="335" mass="37142" checksum="F5DA40091F8FA1F6" modified="2021-09-29" version="1">MATFAREVRSIFRPNLFKKKVAIVTGGATGIGHAIVSELLYLGCHVIIASRKMERLQAATENFRKQIPASSCSEINYVKCNIREEEEVKNLISTTLSKYGKLDYLINNGGGQFLSPGENITLKGWKAVIETNLTGTFLCCREAYNQYMKENSGVIVNIIADMWKGLPLMSHTGAARAGVYNLTKSLAVEWAGSGVRINCVAPGIIYSETAAANYQENIFQALIPQIPAKRLGKPEEVSAAVCFLLSPAAAFITGETIKVDGASSLYASMFHVPEHTQMPAYSWDVKENDAFEKPNPIGWTNENIYRNIWPQSQILRKRLLHLTSRIYEERNVISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ASU9</accession>
    <name>A0A812ASU9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_4986</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000165">
        <property type="protein sequence ID" value="CAE1156930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ASU9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032864899" evidence="1">
        <location>
            <begin position="22"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1156930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="272" mass="29699" checksum="1A49924EBF0D6C8C" modified="2021-09-29" version="1">MGFNSLVSLSPLVSLSPLVSLSPLVSLSPLVSLSPLVSLSPPVSLSPLVSLSLSLSPCLSLPLVSLSPSRSLRSLFRGLLTSFSRSPHLFFAVSSPLFRGLLTSFSRSPHLFFAVSSPLFRGLLTSFSRSPHLFFRGLLTSFSRSPHLFSRSPHLFSRSPHLFFAVSSPLFAVSSPLFAVSSPLFMVSSPLFRGLLTSFRGLLTSFFAVSSPLFRGLLTSFFRGLLTSFSRSPHLFSRSPHLFSRSPHLFFRGLLTSFSRSPHLFFAVSSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ATL3</accession>
    <name>A0A812ATL3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_5479</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000181">
        <property type="protein sequence ID" value="CAE1157931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ATL3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1157931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="265" mass="31738" checksum="02CEBCB537CFA1E6" modified="2021-09-29" version="1">MYLSIYGKHFIYIYPSQSFHIYLSIYLSIYLSIYLSQSVYYHSTFFFPFLSFFLSFYTSMPVISSLYQYFHIYPSQFLHIYLSIYLLSVYLSYYLSIYLCQTFYPCLYQYFHIYLSMTVFSYLSLYLSIYLGLFIIYLSIYLSIYLFIISLSFLLSIYLSMPDILSLSISSFHIYLSIYLSIYLSIYLSIYLSWSVHYLSIYLSIYLFIISLSFLLSIYLSMPDILSLSISVFSYLSIYDSLFISIYLSIYLSIYLFPSQIYVVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AY48</accession>
    <name>A0A812AY48_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_6476</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="CAE1160595.1"/>
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            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1160595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="322" mass="35673" checksum="6700F751765C5E60" modified="2021-09-29" version="1">MGLCIYHFHSKNSPFHLSLSCHKRLTLIYSYDSSPFPLSLSLSVAPCLYLFLSQFPFFFSLSPLSLPLSLSLSVPLSRTMPPFLWVLSVPHLPLSLLVAPFIYLFHSQKSFLSHLSSLLVAPFPVSFSHPFIYLSLLPFSSDPLPLISFFLIPLSSISLTLSSPFPLSLSLSVAPCLYLFLSQFPFHLSLSLSVAPFLYLFLSQFPFHLSLSLLLVFSVPLSSISLILSSPFPLSLSLILSSISLTLSSPFPLSLSLSVPLSSISLTLSSPFPLSLSLSVAPFIYLSHSHSPLPLCLSLTLIHFIYLFHSFIAPFIYLFHPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AZJ8</accession>
    <name>A0A812AZJ8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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            <authorList>
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                <person name="Bekaert M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
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    <sequence length="483" mass="56837" checksum="89C98A8854115DDD" modified="2021-09-29" version="1">MPVIAFNISSSSSSSSSSSSSSSSSSAFISFVFFFFFFLLLLHLFAFSSFTFFLLILLLLLLLLLLLLLPPVFLSFFFFFFYFFFVASSSSSFPPPPPPFLFFFYPFSFLLLLLLLLLLLLLLLLLFRLLLPFLLFLFLLLLLFLYQATSGRILMPCPPVQVQIKSQPKHKNQYFPTNDVIRSYFYPRDIQFIICLFYVLFSFLLFSPSLPPSLSLSLFLSLMSNFLYQFIVISVCIYLHHNMKTYPSHFHLYSSLDACLSVYPVFIPYLSIYLSIYLSIYLFLIYAYFIYLSIYLSIYLSIYLSILRSCLRLILYIYLSIYAVFIPYLSIYLSIYVSIYLYFLPSFLPFLLSFLSFFISFFNSFLTSFIPFFISFLNSFLSFFLSLIPSFLHSFLSFFLQFLHCFIHSFLSFFLFFLSSVPSFLTFLLSFHTFFNSFLPSFLSFFNSFFPSFLSFLSFFNSFLPSFFPSFLFLSFLSFFLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AZM2</accession>
    <name>A0A812AZM2_ACAPH</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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        <name evidence="2" type="ORF">SPHA_6682</name>
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        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
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            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
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    </reference>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="CAE1161079.1"/>
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        <source>
            <dbReference type="EMBL" id="CAE1161079.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">Farmed</strain>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:cytochrome-c oxidase activity"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Cyt_c_oxidase-like_su3"/>
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    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="CAHIKZ030000302">
        <property type="protein sequence ID" value="CAE1167569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B3S0"/>
    <dbReference type="OrthoDB" id="1108038at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056521">
        <property type="entry name" value="MARCHF6-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13145:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MARCHF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13145">
        <property type="entry name" value="SSM4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23113">
        <property type="entry name" value="MARCHF6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="E3 ubiquitin-protein ligase MARCHF6-like C-terminal" evidence="11">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF23113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAE1167569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="192" mass="21301" checksum="52136D39748060A8" modified="2021-09-29" version="1">MGPHWWLKRAIEQVYNDGFRNMNLRFILVKLCAPVIAALGMALAMPYVISKSIVPALGFSPSVQNLVLRRIYPTLLATIIMIVASIFQARQFKRLYEHIKNDKYLVGQRLVNYEPKKPFTGHNSPSFAGMTFSQAQQPAQQQQPAIAAVQQQQQQQQQQQEGNIGVDILPGPLLQPAGAAPGGNAGLQQRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B4B1</accession>
    <name>A0A812B4B1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_9022</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000290">
        <property type="protein sequence ID" value="CAE1166718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B4B1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="315"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="344"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1166718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="363" mass="43606" checksum="4C9704B801156DD2" modified="2021-09-29" version="1">MISTSSLFVSVFFFSLWLFSFTHTLHFIFFLYFLKFSFSLYFLFSSYSLSFIFLLFSVFLLVFDTFLFFSIFLFSFFLIFSIFIFPSLFVFILFSLSLLIVPFSFSSALFNVLSFFFLSFFLLSFFYFFFFNLFLFFIPFHIIYSFFIFSSSFFFLSPYCIFFPLPNSFLLFILYFLLGVLSRFLKLCPSPLPWLLALSIPSCHGTLHSPTILALHKFWQYRTRYQNWQSHSFSLSYYHSFCLSFFLSSTVFLSLSQHLCLVLIFLDTFHSFLTTFLYFLSLSFFLSFFFLSFLTTIFFFFLNKFSFSLSFFHSFFHNIVTIFSFFFFILTSFLSFLINNFAVFLFFFHYSLSPCLLSFSFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B529</accession>
    <name>A0A812B529_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_13064</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000435">
        <property type="protein sequence ID" value="CAE1174289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B529"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032906626" evidence="2">
        <location>
            <begin position="19"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1174289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="240" mass="27358" checksum="267449113AEF210C" modified="2021-09-29" version="1">MSHFLFLFLSLFIYLSLSSHTLSLSSEKKSIISDHLYMSDFLSVSLSFPLFLDFSLSLSLCLSAENKVYHFRPSLNVSLSLSLSFPLFLDFSLSLSFSPRSLSLYSEKKILSFLTISKCLNFSVSLSFPLFLDFSLYISFENKIYHCRPSLNVSLSLSLYLTLSLFLPLSSLSSEKKFLSFLTISKCLTFSHYLSLTFSPPIFFYLLKKGLSFQTISKCLTFSLSLFFSLFLPPLSFSIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B820</accession>
    <name>A0A812B820_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_12091</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000402">
        <property type="protein sequence ID" value="CAE1172449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B820"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1172449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="208" mass="25021" checksum="D6666549D3B146AE" modified="2021-09-29" version="1">MLCLYSNKRKSFFLSFFLSFFLSFFLSFFLISLPNFSLPFFLIDPFCLSFHFTFYLQSTSLSHRSFVCLFVCLFVCFFLSFFLSFFLSILIFLSIFSLPLRSFLSFFLSFFLSFFLSFHPYLTSNLPLSFLFFPFFLSSFILFSFFSYSFLSFFFIALPFFFLFCFFVSFLLSYGIIIYPFFLSFFLSFFLSFFLSFFLSFFLHITAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B8Y6</accession>
    <name>A0A812B8Y6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CHRNN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SPHA_12282</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000411">
        <property type="protein sequence ID" value="CAE1172861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B8Y6"/>
    <dbReference type="OrthoDB" id="5975154at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19051">
        <property type="entry name" value="LGIC_TM_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000073">
        <property type="entry name" value="Neuronal acetylcholine receptor subunit alpha-9-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="6">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="7">
        <location>
            <begin position="113"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAE1172861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="353" mass="39634" checksum="99FD09C09D26C060" modified="2021-09-29" version="1">MYNSANEVFDGTFPTNVVVFHNGECFWVPPGMFKAHCKLKFGSWTHDGRFLDLQLDNPDGGDISSFIRNGEWKLIAMPVELNVVSYECCPEIYLDATYTIHIRRRTLYYGFNIIIPCVLISALSLLLFILPPDAGEKISLGVTILLSLMVFLLLVAETMPPTSDAVPLIGVYFACIMVTCSVSVVLTVWVLNYHHRSPETHTMPNWVRKGICGWLAYVLRMSRPGIERVRMPKKHTVQNSRAQDMKLIERSSKSLLANVLDIEDEIRPDNPNGGVKPPLPLIADNAGRGELMAILKEIQKITRKYKADEDDEEVKGDWKFAAMVIDRLCLIICGLFTILSTIIILASAPHLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B9N3</accession>
    <name>A0A812B9N3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_12826</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000429">
        <property type="protein sequence ID" value="CAE1173886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B9N3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1173886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="205" mass="23630" checksum="900017D1C33555E2" modified="2021-09-29" version="1">MRLLSKPKCSEMRLSLQENQQRYDADSPNQPAERYGSLSKPNSKEMWLSLQANQRRLFSRRQTLQKPKHRSAERFGCLSKPERCSCLFKPNSREMRWLSKPISREMWLSLQDNGKTSQAKKVGGSKYDYLNQLINRETRLSLSPPSNQTVSPRQSGLMQLSLKPKLINRETRLSLQAKQWGDVSPTLCLSKPNSRGDAMPLHAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B9N6</accession>
    <name>A0A812B9N6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_14096</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000479">
        <property type="protein sequence ID" value="CAE1176328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B9N6"/>
    <dbReference type="OrthoDB" id="6048357at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1176328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="161" mass="18229" checksum="3FE4DF58FB57F1A3" modified="2021-09-29" version="1">MRPYPKQYPPWKNGCYMWEPRGIPHGCRAPGVPFKMHIPNAIQVMVRAGNEWTELENVEEHVFQGLVDFSKPDMANGGVTKLRPAGRIETTEREGQFCGRGKYVTSLSWVLPCFSEERICSLSLLHDISLNSLFLCFVCCITPTWLFLSSCITFKSTATHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BA86</accession>
    <name>A0A812BA86_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Aconitate hydratase, mitochondrial</fullName>
            <shortName evidence="13">Aconitase</shortName>
            <ecNumber evidence="13">4.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">SPHA_13137</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Farmed</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>citrate = D-threo-isocitrate</text>
            <dbReference type="Rhea" id="RHEA:10336"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="EC" id="4.2.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="13">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.3" evidence="13"/>
    <dbReference type="EMBL" id="CAHIKZ030000437">
        <property type="protein sequence ID" value="CAE1174526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BA86"/>
    <dbReference type="OrthoDB" id="2224430at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00718"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003994">
        <property type="term" value="F:aconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01584">
        <property type="entry name" value="AcnA_Mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.19.10:FF:000002">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000003">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000004">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1060.10:FF:000001">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1060.10">
        <property type="entry name" value="Aconitase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050926">
        <property type="entry name" value="Aconitase/IPM_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015932">
        <property type="entry name" value="Aconitase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006248">
        <property type="entry name" value="Aconitase_mito-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01340">
        <property type="entry name" value="aconitase_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005558">
        <property type="entry name" value="PRK07229.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160">
        <property type="entry name" value="ACONITATE HYDRATASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160:SF3">
        <property type="entry name" value="ACONITATE HYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0408">Iron</keyword>
    <keyword evidence="9 13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11 13 17" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="15">
        <location>
            <begin position="71"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="16">
        <location>
            <begin position="587"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="780"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="806"/>
            <end position="820"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAE1174526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="820" mass="89461" checksum="6EE68BB1DED240AF" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BB79</accession>
    <name>A0A812BB79_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_16565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000585">
        <property type="protein sequence ID" value="CAE1227849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BB79"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="305"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="418"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="458"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="484"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="509"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="543"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        </location>
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        </location>
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        <location>
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        </location>
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        <location>
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        <location>
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        <location>
            <begin position="1242"/>
            <end position="1267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1227849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1269" mass="150770" checksum="8272236B96259D22" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BBR9</accession>
    <name>A0A812BBR9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_13796</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000464">
        <property type="protein sequence ID" value="CAE1175739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BBR9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
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        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
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        <location>
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        </location>
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        <location>
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            <end position="147"/>
        </location>
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        <location>
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            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
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        </location>
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        </location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1175739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="411" mass="48148" checksum="4EC0558D8BB5CF5D" modified="2021-09-29" version="1">MPKMAKSQHSVCLSVALFISIYLSIYLSIYLSIYLSIYLCLSVHIYLSVRGYIPLQQSVYFFISIYLSIYLSIYLSIYLSICVPACSYISICLCYIPLSLSLLILYLSYNLGWQTVYNGKNRLPTAVYFYSVSVFFPFPFLGCSHYICVFPFIFFFFTLFLLFCFPYYFFIFSLLFFVLFVLIYFVFCLTVFFFFFFYHAFFISSSSSSSSSSSFTLYLPSSTSLPPVFFFLLILLPLFFFFLHLFFFIFFFFFFFFFFFFFSHLFFSHSSTSSSSSSSSFLIYSFLILLLLLLLLLLLLLFFFFSHLFFSHSSTSPPSPPPSIYYLILLFSSILFSFFFFSSFPSSFPSSFHLLSYSSFLIHSFLILLLLLLLLLLPSIILFFFSHPFFSHSSSSPPSPPPSIYYLILLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BC80</accession>
    <name>A0A812BC80_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Trafficking protein particle complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SPHA_15641</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Farmed</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Core component of the TRAPP complexes which has a function of guanine nucleotide exchange factor activity for Rab1 GTPase. Plays a role in vesicular transport from endoplasmic reticulum to Golgi and autophagy. May play a role in dendrite postsynaptic membrane trafficking.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the multisubunit TRAPP (transport protein particle) complex, which includes at least TRAPPC2, TRAPPC2L, TRAPPC3, TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, TRAPPC11 and TRAPPC12. Interacts with SDC2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Part of the multisubunit transport protein particle (TRAPP) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Golgi apparatus</location>
            <location evidence="9">cis-Golgi network</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAPP small subunits family. TRAPPC4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000546">
        <property type="protein sequence ID" value="CAE1225188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BC80"/>
    <dbReference type="OrthoDB" id="246406at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14856">
        <property type="entry name" value="TRAPPC4_synbindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.70:FF:000009">
        <property type="entry name" value="Trafficking protein particle complex 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007233">
        <property type="entry name" value="TRAPPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249:SF15">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04099">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01399">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 9" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="5 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00046052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAE1225188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="216" mass="24435" checksum="C9338CB16AA048A1" modified="2021-09-29" version="1">MAVLSVYIINKAGGLIYQYDHNSSRPEIEKTFGYPLEVVLKVHDDKVVVAFGERDAIKVGHTVLGINGIQAEGRFLRDGRDILEVLAAEENYPINIKFGRPKLTTNEKIMLASMFHSLYTISCQLSPEPRSSGIEMLETDTFKLHCFQSMTGIKFIALTDPRQVGVDQLLKKLYEVYSDYALKNPFYSLDMPIRCELFETNLQVCIEQSERAATGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BEX2</accession>
    <name>A0A812BEX2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_18759</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000678">
        <property type="protein sequence ID" value="CAE1232908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BEX2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1232908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="161" mass="19143" checksum="D4394F0E40E330AD" modified="2021-09-29" version="1">MDAFVSRNVVFYFSLSLSLSLSLALSLGSSEYSFFAPIPFLQLIHICSMHSFRSFIVIFFFFFFFCLLEFFFQTALYLLLFFLFVAFVLNFAKLFFYQNGPFLLFLCLLVSLSFFLSFFLSFFLSFFLSFFLHISFRSRLSGMIFLSFFLSFFFLSFFLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BGF5</accession>
    <name>A0A812BGF5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_15628</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000546">
        <property type="protein sequence ID" value="CAE1225162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BGF5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1225162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="220" mass="26164" checksum="51D9B5DC3C075F46" modified="2021-09-29" version="1">MDQSESTLRLHSSDETVELDSAYVPTLYFSQHIKDEFSYQLSKKIQTLPKEEQLFVSIYLSIYLSICRDQREDTTTLSIFVCLYLSIYLSIYLSIYLSQFVYIYLSQYTSSIYLSIYLSIYLSFSFFKRYESISLEHRLSASLNKLLFLVHPLFLSFILSFFLTSIFLSFLPSFLLSFFISFFLSLSHHYNFFLLFLISTHQCFLSFFLSFFLSFFLSYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BHH1</accession>
    <name>A0A812BHH1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_17621</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000630">
        <property type="protein sequence ID" value="CAE1230256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BHH1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="572"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="613"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="653"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="693"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="736"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="761"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="803"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="844"/>
            <end position="866"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1230256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="899" mass="103055" checksum="B36BA98875CDC94B" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BL58</accession>
    <name>A0A812BL58_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_19657</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000713">
        <property type="protein sequence ID" value="CAE1235120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BL58"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1235120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="219" mass="25220" checksum="AF3A78D08AB052B4" modified="2021-09-29" version="1">MKPLQIRSKSMYFTRLNFSFSSFSKITHLLSIYLSPSVCVWVRTCRLERKRDVTPISLLFNANPTTHPLWTKLCHALVPFMSTALISHTHTPQSLLGLPAGRPVYHSTKGFFFSLFLSFPFFLSFFLSFFLSFFLSFFLSVRPFWFPPFSLFLWATLLFVNFLFLFLDAYLRQGPGISLNSYCLPQRVIFIFLPLSLSLSLSLSLSLSLSLSLSLFPCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BPK8</accession>
    <name>A0A812BPK8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_20516</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000751">
        <property type="protein sequence ID" value="CAE1236989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BPK8"/>
    <dbReference type="OrthoDB" id="6153212at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1236989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="221" mass="26411" checksum="C4A6004DBC4A563D" modified="2021-09-29" version="1">MYSIYYLSLSIIYHPSIYLYIYVFHLSIYLSIYLSIYLSIYILYVCDSIYIYLSIYLSIYTRMYSNYLSIYTRMYVYLSIYLSIHMYVYVIPSSIYLSISIYLSIYLYLHVSISVSIYLSICLSIYPCKGLSIYLSIYTRIYVIPSTISIYLYYLSFYPSIHLSIYPSIYDLSIYLSMYVIPSIPSIHLSILYLYIYLSISIYPISIYIYVSIYLSIYIHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BRV8</accession>
    <name>A0A812BRV8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_22930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000846">
        <property type="protein sequence ID" value="CAE1241516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BRV8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1241516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="248" mass="29230" checksum="73A7DC249EDC4FFF" modified="2021-09-29" version="1">MVVGLFFFSFFLSFFLSCFMISSILSFILFFFFTLIFFNFFLNIFDFLIPNSTSLLPFFLSFFLSFVFLLVLLFYFRYFFNDCLVSNILSFFLSFYFRFFLFFLIFLFSLFLLNVFFSFFHPLFFLFLLILSSFDILSYCSFLMLSTLFLFSFFLFFFCLLFILPSSSSSSSSSSSSSSSSSSSSPFTSFHYSSLSYSSCSNFHSCYFLPNSSSSLYFLIVVHFFFFPILPLLIYFIHPPTRLSVLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BSS8</accession>
    <name>A0A812BSS8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_21476</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000788">
        <property type="protein sequence ID" value="CAE1238783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BSS8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1238783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="309" mass="36389" checksum="CCA786CD1547FF98" modified="2021-09-29" version="1">MSPSSSFSFLSFIFSYFVFSSSFLIFFCFFLPPPSFSFAFPSFSAVTIPPLLFLLFFSSIIVSYYFFFSYVYSASTFADSPPPFLSFLLLPLLVLFLCSSLLLYLYLFSSFCPPPFTFSTSTIPTPLTSSGFLLLLCLLLLLHRFLRLPFILYFYYYILFYLISFYFAFSSSTFVFFLFFIFFLFTSYFLSFLKYTYFFFFLFILFLLYFLYSLSVIQIFFFPSFFFHRFSSSSSPTTTFFPVIHGVHKSVHIYLSIYLSIYLSIYLSVIIFMSIYLSISLCSCQSIYLSIYLSIYHSLFISIYIFSDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BVT3</accession>
    <name>A0A812BVT3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CCND2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_26354</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001005">
        <property type="protein sequence ID" value="CAE1248925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BVT3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1248925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="263" mass="30407" checksum="4A842E0D6AE522D7" modified="2021-09-29" version="1">MKIRIIKYKTFFFFPSFIYFPPFFSFFPFFLFLFPFLLCRTGWLQDLSGVKIKIADSFKDIPKIRVPHMRLDRNKIMEKFNYDFDLEERTKVLIVGVVIYLSIYLSIYLSIYLSIYLSMFISIYLPILSTYFIYLFCLQNQSLLAGRPTKITQKCQEELVPVAVASLLDALPVLSTRKKGCSILMASAMRQVALASKTSLTRRFFSRTALPQLRVSQGDVSSQSRNFDHFILPAALVLTVFGVSVSLFSTHQLSYNSCRSLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BWY3</accession>
    <name>A0A812BWY3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_25634</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000969">
        <property type="protein sequence ID" value="CAE1247349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BWY3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1247349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="254" mass="29603" checksum="453FF56F328F4812" modified="2021-09-29" version="1">MRTGLTFSIDHLFNLPCYVTVSISISPNSCFVRVTFYSSVLTAEILSRVIYSLFLSFFFPIPLFLNRFSFYCSSFLSFSFLPFSLPFFLLFSSLFLSLFFPSSYFFSSSVLFSPLFFFSFSHLFSLLPFSFLFSFFFSNPFSIHFLFFLFLFFFYLLLFLLSSIFLLPFFFLLSSFFLSFFLSFFLSFFLPIFIFHLFFVAGLLLGDTCINIYVPPPSVSLSVSLSLSLSLSLSRARVNIYLSIYLSIYLSIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BXW6</accession>
    <name>A0A812BXW6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_26229</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001001">
        <property type="protein sequence ID" value="CAE1248442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BXW6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAE1248442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="254" mass="30937" checksum="E1D94D5C4BB58E76" modified="2021-09-29" version="1">MLIPAAHPTYFCSIYIYLYLYIYLYISIYIYIYIYLYLYISISLSISIYLSISIYIYIYLYLYIYLYLYISIYINLYLSLSISYLSINIYLYQYLSISIYISIYIYLYQISIYISIYINIYLYLYQYLSISLSISISIYISINIYLYLYLYLSISISLSISIYLYQYLSIYLYQYLSISISSIYLSISISIYLYQYQSIYINIYIYLYQYLSIYINIYLSISISIYLYQYLSIYLSLSLSIYISIYINMVCGYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BZJ7</accession>
    <name>A0A812BZJ7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_25018</name>
    </gene>
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        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
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            <taxon>Sepiidae</taxon>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
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                <person name="Bekaert M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
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    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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            <begin position="162"/>
            <end position="195"/>
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            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAE1246175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="196" mass="23439" checksum="4B384493A1DC217E" modified="2021-09-29" version="1">MFYIDCSRLSYAVVYICRVVLLSIYLSIYLSIYLSIYLFICTKISSYLSIYLSIYLSIYLSIYLCLLVHMHYSLYISIYLSIYLSIYLSIYVCIPINNVNLSLSIYLSIYLSIYLSIFLYICLLLFRILIRCLVLFFIFFFFCFVFFFFFFLFFFYFFFFFFFFVVVVVVVVVVAVAVAVVDVVFLFVIASSFFFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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    <name>A0A812BZN5_ACAPH</name>
    <protein>
        <submittedName>
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        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">Farmed</strain>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BZU4</accession>
    <name>A0A812BZU4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_26725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
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    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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    <name>A0A812C1E5_ACAPH</name>
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        <submittedName>
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        </submittedName>
    </protein>
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    <organism evidence="2 3">
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">Farmed</strain>
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    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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            <begin position="280"/>
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        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="329" mass="38027" checksum="57D85D26D7DD5B7B" modified="2021-09-29" version="1">MFISGKGTFPSLYSSLLFISLSLSFFQFPLLSFFLFLFLPQNLSFFLNTFSFLFCLISSFPFPSLFLFLLLFLFSYLPPPPLFLFVSHLPPLLFLQPLLFSPFVFLLLHPLILHASFFFFSSSFFFFFFFFFFSSSSSFFFFILYITSSFFFLFFLLFLYSSFSFILHHHHHHYHHFIASPTSSPPLFSFSLLTCTSSFFSYYLSSSSSSSSSSSSTSSSFFFSLSICFPSPSFSVFCYFFFSPSSFASCPLLFPLSLHFLSLLIVFFLLFFFSSLPSCFSSSLSLSFFLSFFLSFFLSFFLSSPFSSHPASSCSFFFPLHIISLNFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C686</accession>
    <name>A0A812C686_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_33370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001396">
        <property type="protein sequence ID" value="CAE1262739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C686"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1262739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="206" mass="25065" checksum="8A2C043F342D6852" modified="2021-09-29" version="1">MLISYAENSSLPTPKMSISKSEKTKNFHFLPLFFSFFPFPSFFFLNFFFLPSFFPSFSFIFPFFPFFFFLSFFFSFFLSFFLFLPHFLPSFFFFLPSFFLSFFLLFPFFLFLPSFLPSFLFLFFLFFLPFFLFFFSFLPSFLPSFLPSFLPFLIFSFLPSFFPFFFFLPSFFLPSFLPPSFSFFLSFLFPSFLPFFFSSFLPSFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CAJ4</accession>
    <name>A0A812CAJ4_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Beta-lactamase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_30744</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001240">
        <property type="protein sequence ID" value="CAE1257421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CAJ4"/>
    <dbReference type="OrthoDB" id="5946976at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052907">
        <property type="entry name" value="Beta-lactamase/esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43319">
        <property type="entry name" value="BETA-LACTAMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43319:SF3">
        <property type="entry name" value="BETA-LACTAMASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="317"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="372"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="402"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase-related" evidence="2">
        <location>
            <begin position="46"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1257421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="424" mass="49475" checksum="EDCB66C8A0BDA728" modified="2021-09-29" version="1">MAFLGLLILISLAVLSIWFLFCRRKRNKLRVRVERSFVDPRFEKVAQVFRESFESGAETGAAFAVYYKGELVVDIWGGYANRTGRIPWRENTMSTAFSTSKGINALLVAKFVELGYLDYKKPVCHYWPEFAQNGKEAITVEMLIFIFIYVSQSVHVDFGSYLSIYLSIYLSIYLSIYLLVHIYLSIYLSIYLSIYLSLFISQSLHIYLSIYLSIYLSIYLSLHIYINLSISQSLHVYLSIYLSIYLSIYLSIHYLCMYVCMYVCIYFSLFRSIYLSIYLSKSLHISVSSYLSIYLSIYLSIYLSISISPYLSLFMHIYLSIYLSIYLSIYLSIYLSISSLSIYICMYLSILVSSDLSIYLSKSLHISVSSYLSIYLSIYLSIYLSIYLSLHIYLNLSISQSLHIYLSIYLSIYLSIYIYIYIYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CAK1</accession>
    <name>A0A812CAK1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_29953</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001202">
        <property type="protein sequence ID" value="CAE1256025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CAK1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1256025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="329" mass="38784" checksum="EA8DDFF9CA477558" modified="2021-09-29" version="1">MSFLFLCLSFQLPVFCCSNIYFTLHSFFLLSSFFLSFFQSFYFFLLFFPNFFFSIFLFFHVFLLSFFFFFFFLSFFLLFYTFLFLPLPHLFFLSFFLSFFLSFFLSFCRSSFTPQRMNCLSCSFFFSHSTRLSLSNLRYLFPLSTYWPRADAACVLTENAEDSFEIHGESRTIASKIQSAHHALYSQGKGVNSVSKSIYLSIYLSIYLSISVFSSSIYLSLSFPRLSIYLSIYLCLFLIYLSIYLSIYLSIYLLLVSSFCSYLSIYLSITFCLDLSIYLSIYLYNSLSICLHILLLPEYTTINQSIYLSIYLSPFISIYLSTDTQFENH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CAX0</accession>
    <name>A0A812CAX0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_30104</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001210">
        <property type="protein sequence ID" value="CAE1256340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CAX0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="381"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1256340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="413" mass="48897" checksum="BA6C459FCB015489" modified="2021-09-29" version="1">MSHHFSREWYDSTSHSLFIIYLSIYLSIYLSIYLFLFCLSIHLIPFNIIYYLFRSPHHIYLFRSAHYLSIYLSISVCALSIYLSIFIRSAHYLSIYLSIYLYLSISICSYLSIYLSIIYVCSLSIYLSIYLSIILSIYLSIFVHYLSFYLSIYLSISIYVCSLSIYISMFVHYSSIYLSIYLFFYLCLFFIHYHSSLSIYLSIYLSIYLCLFIIYLSIYPSMFVHSIYLSDHPSIHLSIYVCSLFLSIYLSIYLSIHVCSSITFIYPSIYSSIYLSIHLSMFVHYLSIYPSIYLSIYLRLFHYLSIYLSIYLSIYLSIHLSMFVHYHSSIFYLSIVCSLSIYLSISIYLNLSSIYLSIHVCSSIYLSIYLSYWKYLCSLSISIYLSIHLSIIHLSIYICPSIHLFIYLSMFCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CE09</accession>
    <name>A0A812CE09_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_34199</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001446">
        <property type="protein sequence ID" value="CAE1264286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CE09"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1264286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="184" mass="21405" checksum="C65A798BE43F362A" modified="2021-09-29" version="1">MFSFPKISSFCTRSFLLLLSMLLHSFCLKEKGNKKSAYFPLSFPSSPFSTFLSLVFLFVFLSLFNLAPLFFLIFSLIIPFYFSSFSLILFLFIFLSQSLLPFLFFSNSSSINLANFNNIYLSIYLSIYLSIVIHRQTASELFICPLFLKKPVKIVEKSCFHSQNQSHLSIYLSIYLSIYLFPYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CEN0</accession>
    <name>A0A812CEN0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_32043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001333">
        <property type="protein sequence ID" value="CAE1260182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CEN0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1260182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="297" mass="34427" checksum="40E8A5AC40A43D90" modified="2021-09-29" version="1">MLGAAGLFRCGRRGQPRRQRGGHSTAAQVSLSWPAVKRTAVKAVAYEHSIIIVKVVSGLFKHHAEKDAEKDAEHSRCQDTTLFHDVAMGKDTDRSLIVRLLEKLFVDRGKPTGDERIALVRPPSLGPSSAVLSLKELPGNAVVSEWFPSFSFFFLSVNFLHLADEFISCVDKFSSQLLTASDSTLYVSFLSNMVITFFYRRVSSLLIYLFIFTFSRNRRETLLSTLLSFFLSFFFFFLFFFFSFFFIFFPFFISFSFFLSFFSFISFSFFVFSFFFFFFLSFSFFFLLLFFLSFFSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CF14</accession>
    <name>A0A812CF14_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_37971</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001713">
        <property type="protein sequence ID" value="CAE1273115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CF14"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1273115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="261" mass="30627" checksum="5D31235E49F80079" modified="2021-09-29" version="1">MIGKKLLFSDETHFEVRSHRSLFVRRNKGNINQLKNFTHIIYLSIYLSIYLSIYLSMCVLIFLLYLFLFFFNSFLSLSLSLPVLQIFPFLLFSGGFFFSFFNISYFFSLSPYPISLQHSFFSSTLLHILLFHKHSLFSLTDCFLFFLSHIPSSTFSSLLLLLLLLLLLLLLLLLLFHLLTILFFFFLIKLSFLSHILSILFSFPSSDLVVSLLSFLALSLFFQSYTFHTLYRLIFALPLSFVFFFLQSPSLLSNLYFIFVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CG70</accession>
    <name>A0A812CG70_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_35180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001511">
        <property type="protein sequence ID" value="CAE1266436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CG70"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1266436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="219" mass="26071" checksum="AC11C25E56853669" modified="2021-09-29" version="1">MRQFEAISQTTFWGSIYLSIYLSIYLSIYPSFLISIYLSIYLSIYLSVYLSIYLYIYIYIYIYFHMFIIYVISYLSIYLSIYIYIYIYIYIFFHMFIISVISYLSIYLSIYLSIYLSITVCSLSIYLSIYSSIYLSIYLSLSSPTYFFVSNSVFPCLCNMRTRVYITLNLPHSLSFPSPPISLFSLSFGEMNLQAKMSLRCQSFKYLSIYLSIYHLSIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CGT9</accession>
    <name>A0A812CGT9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_35008</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001502">
        <property type="protein sequence ID" value="CAE1266065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CGT9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1266065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="226" mass="27453" checksum="647565A4C6292852" modified="2021-09-29" version="1">MILAGDVKHFFFFLSFFLSFFLSFSKPDQESSYLETLNTFSFFLSFFLSFFLSFTETKQRDVKHFFSFSFFLSFSFFFFSFTETKQPYVFSETLNTFSFFLSFFLSFFLSFFLSLKPSSVSDMSSLSFHETLNTFFFFFISFFLSFFLSFFLSFLKPSSTLNTFLFLSFFLSFFLSFFPFFPKPRILSYLFLTRSFLIYERRDVKHFFFLSFFLSFFLSFFLSFFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CKW8</accession>
    <name>A0A812CKW8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Isthmin-1,Isthmin,Isthmin-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SPHA_37214</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001656">
        <property type="protein sequence ID" value="CAE1271426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CKW8"/>
    <dbReference type="OrthoDB" id="9930623at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005533">
        <property type="entry name" value="AMOP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051867">
        <property type="entry name" value="Angio_Inhib/Adhesion_GPCR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10239:SF29">
        <property type="entry name" value="AMOP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10239">
        <property type="entry name" value="ISTHMIN-2"/>
        <property type="match status" value="1"/>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CLB0</accession>
    <name>A0A812CLB0_ACAPH</name>
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        <submittedName>
            <fullName evidence="4">NPHP4</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">SPHA_39299</name>
    </gene>
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        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
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            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
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        </lineage>
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            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CMV3</accession>
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            <fullName evidence="9">Carbohydrate sulfotransferase</fullName>
            <ecNumber evidence="9">2.8.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SPHA_38349</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Golgi apparatus membrane</location>
            <topology evidence="1 9">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the sulfotransferase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.-" evidence="9"/>
    <dbReference type="EMBL" id="CAHIKZ030001735">
        <property type="protein sequence ID" value="CAE1273621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CMV3"/>
    <dbReference type="OrthoDB" id="2019940at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016051">
        <property type="term" value="P:carbohydrate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018011">
        <property type="entry name" value="Carb_sulfotrans_8-10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005331">
        <property type="entry name" value="Sulfotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137:SF54">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03567">
        <property type="entry name" value="Sulfotransfer_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 9 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="417"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="428"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAE1273621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="437" mass="52012" checksum="7BDCA2C6BE3A2A2E" modified="2021-09-29" version="1">MFLLVTTWFIPRRWSTAGQRRRYNRSYSSAGVPVVGNFRVKYGVMGKRMKMPMPKLLLGLMVCGTLMPLIYFILLSYPNSTPTITETVVQSLLQKNNSRRAEAPLPLSPDIQNQIRMDPVFTWEKEYTNFMKDQEHRKKALRNACRTLGLIAHKNKIKKEDLYSVIVNDQYGFMYCQIPKVACTNWRRVLLVLTGFYNTTEASELKAKHVHDSYDRDLTYLSELSSGGISYRVKKYKKFLFVREPFERLLSAFRNKIQNHQNEYFFEKFSRKILKKYRDRNMTSETMRQSNVTFIEFVRYLLDPSTRKRGLNDHWEHFNTLCHPCLLKYDFIGKYETLDRDAYFILRNLTPNHWVRFPSREETYKHPTTTNLVAKYYRSISPRFVQKLWKMYEKDYMLFDYQYPSWLPPLKLNSSSFSLQSQPPPSDEPQQSISVIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CP39</accession>
    <name>A0A812CP39_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_39600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001852">
        <property type="protein sequence ID" value="CAE1275682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CP39"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1275682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="268" mass="31319" checksum="57BAB532AE00D09D" modified="2021-09-29" version="1">MYTFNCYLYKLSISSFSAIYKNRTFSLSLSLSLSLSLSLSLYLSIYSNLSLDSYHILFLSIYLSIYLSIYLSICLSVCFSIVLSSYLNLLISLFTSNYHSPFVHIWQSTKNGTLSIYLSIYLSIYLSICLSVSLFSCLLINILHLFISGNLQKWNTIYLSIYLSIYLSIYLSIYLRLVCLYFIYIYLSIYLSIYLSIYVTLFLHIYLSIYLSIYLSIYEILFLSISIYLCNHVLSIYLSIYLSIYLSIYVILFLSIYLSIYLSIYLSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CQ65</accession>
    <name>A0A812CQ65_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_38958</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001791">
        <property type="protein sequence ID" value="CAE1274585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CQ65"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="297"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1274585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="319" mass="39277" checksum="49BD55782DD4C2F3" modified="2021-09-29" version="1">MAFELCLSSVESRPNHFVFNFLSFFLSFFLSFFLSFFPSFFLFEAFFFFFLSFFLSFFLSFFLSFFLSFFLSIRDFLFLSFFLSFYSKLSFSFSFFLFEAFFFIFFLSFFLFETFFFFLSFFLSFFLFETFFFIFFSFFLSFFLSFFLFETFFFIFFLSFYSRLSFSFLSFFFFSIRDFLFHFLFLFFLSFFLFETLFLIFFLSFFLSFFLSFFLSFFLSSLHFFLHAIFSFHLFFPECLISLSLYLSIYPSIYLSIYLVFSFLSKSSPSYLSIYLSIYLSIYLSIYLVFSFLSIYLSIYLSIYLSIYIYIYIYTAKAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CQN0</accession>
    <name>A0A812CQN0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_38901</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001788">
        <property type="protein sequence ID" value="CAE1274486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CQN0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="624"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="721"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="760"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="792"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="826"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="862"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="901"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="933"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="960"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="398"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="290"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="425"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1274486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="981" mass="116377" checksum="10259D670FD56956" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CUX2</accession>
    <name>A0A812CUX2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_41043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001960">
        <property type="protein sequence ID" value="CAE1278092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CUX2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1278092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="235" mass="27343" checksum="A7E909FA428CEF88" modified="2021-09-29" version="1">MLFPLCVTSSRNCTYAKQSVLFGKTCFIIYLSIYLSSIYQSIYLSIYLSIYLSIVGNSYLSASSLSIYLSIYLSIYLSYLFICMYLSVSYLSIYLSIYLSIYRRKLISFRQFFIYLFIYLSIYRSLLIPLSQCFFYLSIYLSIYLSIISHLSIVVCSYLSVSAFSIYLSIYLSVYLSIYLSIYRSLFLSIYLSIYLSIVVCSYVCSLSVSYVCIYLSLIYLSIYLSIYLSTTFIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CVM9</accession>
    <name>A0A812CVM9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_41924</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002024">
        <property type="protein sequence ID" value="CAE1279568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CVM9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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            <end position="24"/>
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    </feature>
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            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1279568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="283" mass="33371" checksum="472E0F74C7C24151" modified="2021-09-29" version="1">MKKSIQSSCLVLLFLLRLKSSAQQEKTQNTSSVDLKNRFRYNSIHPSIYLSIYLSIYLGPFISISDFNTIFLSIYLSIYFSIFISIHLFLLSIYLFILSIYSHYLSIYLSIYLSILTIYLFTLYIHTIYLSIYLSVCLSIILVIFIYLLCCSYLSIYLSIYLSIYHTGHIYLLRCSYLSIYLSIYLSIYLSICLSVYHTGHIYLSLMLFISIYLSIYLSIYLSIYLSYRSYLSFLCCLYLYLSIYLSIYLSICLSFYHTGHIYLSLMLFISIYLSIYLSIYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CVT7</accession>
    <name>A0A812CVT7_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Helitron helicase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_42480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002086">
        <property type="protein sequence ID" value="CAE1280740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CVT7"/>
    <dbReference type="OrthoDB" id="6153892at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786:SF74">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786">
        <property type="entry name" value="DNA BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helitron helicase-like" evidence="2">
        <location>
            <begin position="465"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1280740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="546" mass="60754" checksum="CF2DE460D0C9C220" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CWR3</accession>
    <name>A0A812CWR3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_41918</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002024">
        <property type="protein sequence ID" value="CAE1279653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CWR3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032376528" evidence="2">
        <location>
            <begin position="18"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
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            <begin position="53"/>
            <end position="73"/>
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        </location>
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        </location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
    </feature>
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        </location>
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    </feature>
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        </location>
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        <location>
            <begin position="793"/>
            <end position="821"/>
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        </source>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1279653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="850" mass="103422" checksum="47700FD3A1A3A865" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CWW2</accession>
    <name>A0A812CWW2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_41695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002013">
        <property type="protein sequence ID" value="CAE1279267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CWW2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="307"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="331"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1279267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="366" mass="42866" checksum="236127F2EB7D3951" modified="2021-09-29" version="1">MTNIQYHYFIIHYYLYFKAVAALFWVFPTLLCRKFFFPTNCKRTFYRNLFFLFFVNGISLKRKKKMDVTKEQILHRLTVLKIKVEERLKLCRGDRVTPHVFSVFRKDILQYIFEMETCITKLELGSFPETDLLETEAEWAPRLMEYHRELGDLDGSFSPSSCLDPVSQSFGAWFPWNCGLLLSGDKIPCEVAHLSFNTVMGIPPEPTRDWLFVVLKDYFFFSALLLDLVGAGRKRRIPFATLTRLSLLSSGKACQRKEQSVAFSIYLSIYLSEPVHLSIYLSIYLSIYLSIYLYLSQPVHINLSICLYQPIYLSIYLSIYLSIYLSKPVHIIYLSIYLSLSIYLSSIYLSKPVHIYLSIYLSIYLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CXT4</accession>
    <name>A0A812CXT4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_43635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002203">
        <property type="protein sequence ID" value="CAE1282751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CXT4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1282751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="163" mass="18980" checksum="B2CD381F5D289853" modified="2021-09-29" version="1">MRALSLRSIPIYLSIYLSIYLSIYLSIDICLCISCVSLFHPPSFFPYLCLARSVLIYLSIYLSIYLSIHLSICNKDLSIYLSIYLSIYLSIYLSQSVHIYLSIYLSIYLSISKIVHIYLSIYLSIYLSIYLSQSVHIYLSIYLSQRSFISSIYHIYLSSIYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D284</accession>
    <name>A0A812D284_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_48176</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002655">
        <property type="protein sequence ID" value="CAE1290160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D284"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1290160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="171" mass="20505" checksum="FB6B926E664A8C1B" modified="2021-09-29" version="1">MDKSDAVSFVFILLFHSYPFFYIFLFVFTLFFLSFFLSFFLSFFLSIHISLFLSIFLSFFLSFSCYLLSLSLNFLFIPFHTISLYCSFFLSFFLSFFLSFFLSFIFFLLYISLPSIFLALHSFCFFHSFFLLISNYVSSTCIYFLFSFPLLSFFLSFFLSFFLSFFLLIVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D4W7</accession>
    <name>A0A812D4W7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">BMP10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SPHA_45399</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TGF-beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002335">
        <property type="protein sequence ID" value="CAE1285347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D4W7"/>
    <dbReference type="OrthoDB" id="5987191at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.90.10:FF:000001">
        <property type="entry name" value="Bone morphogenetic protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001839">
        <property type="entry name" value="TGF-b_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001111">
        <property type="entry name" value="TGF-b_propeptide"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015615">
        <property type="entry name" value="TGF-beta-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017948">
        <property type="entry name" value="TGFb_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11848:SF307">
        <property type="entry name" value="BONE MORPHOGENETIC PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11848">
        <property type="entry name" value="TGF-BETA FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00019">
        <property type="entry name" value="TGF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00688">
        <property type="entry name" value="TGFb_propeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00204">
        <property type="entry name" value="TGFB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00250">
        <property type="entry name" value="TGF_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51362">
        <property type="entry name" value="TGF_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0339">Growth factor</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="29"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="TGF-beta family profile" evidence="11">
        <location>
            <begin position="1158"/>
            <end position="1273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="697"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1088"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="744"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="762"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="779"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="802"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1088"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1104"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1153"/>
            <end position="1163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAE1285347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1273" mass="146279" checksum="741FCD22A382A7BF" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D8A0</accession>
    <name>A0A812D8A0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_49345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002811">
        <property type="protein sequence ID" value="CAE1292534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D8A0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1292534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="338" mass="38449" checksum="D14B37B3B3F08FE0" modified="2021-09-29" version="1">MYFFHLILFLFSPNIFSLLQFLLFLLHYLLTFKKPLIEIYSHSFQFLFSLSLASFVSSVSLLMYFSSNFFLFSPNIFSLLHIFNFINSFFPFALLSPPLPHNISHIITLFFLLSFFLTPFSPPPLFLPDSVLSSPSLSSRLRSLLTLSFFLVLLTLSFFPTPFSPHPSLSSPTPFSPHPLFLPDSVLSSSLSSRLRSLTLSFLTPLVLPSFSPLFLPDSVLSSPSLSSRLRSLLTLSFFPTPFSPHPLFLPDSVLSSPSLSSRLHFSSFTYVFSFFLFHSLYFYSFSIISFLLKIPSLFSTSFFICFDLSFYDSFILFPSLFCSFFSSSLSLSCVATF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DBL3</accession>
    <name>A0A812DBL3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_48860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002755">
        <property type="protein sequence ID" value="CAE1291663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DBL3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1291663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="251" mass="28787" checksum="EF0F7666F9E75241" modified="2021-09-29" version="1">MQTSIYLSIYLSIYLFIYLSIYLSIYLSIYLSNTPILLRHDVCLTCVAHNNLALRSATHSTPQKGGACCGIPWSERKPSNHLTTSLLVIYLSIYLSIYLSISFSLILSLSLSLSLSFSLSLSSANTDRLREQTIQIYLSIYLSIYLSIYLSIYLSIYLLSIYLSIYLSNYLSIYLSLFISKYLSEPIHIYLSESVYVNVFISIYLSIYLSIYLSIYLNLFIIYLSSYLSAISIEPLPFTSVIIRSLLRYIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DBN7</accession>
    <name>A0A812DBN7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_49827</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002889">
        <property type="protein sequence ID" value="CAE1293424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DBN7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1293424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="279" mass="31652" checksum="21B0A39643B1C8BB" modified="2021-09-29" version="1">MSRPAFSPTIHSSIHLTFSLNLSLSLSLSLSPSVSLTHKLLLSLFHLHPPHSLSLFLYCLSLSLSLPSRLSLSSISSLSLSLSFYLSLSLSPSVSLTHKLLLSLFHLLSLSLFLSLSFSLSLSLSLSLFLYHLSLSLSIFRFLSSPPLSLSHRHTHFYILFSLSFSLSWSFHIYLYSFSFFRYFSLPFFYLCRVHPLPVFSCLPLLRTLSLFHPVFPSLNISHSASVYVFMFTAYTQTYSHILIFSESDKHSLCRYIFIFHPSPPLSLSQTICLFLSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DEA4</accession>
    <name>A0A812DEA4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_50776</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003016">
        <property type="protein sequence ID" value="CAE1295162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DEA4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1295162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="214" mass="23860" checksum="EEBAC558169CD94F" modified="2021-09-29" version="1">MMVSQCLHHSLSFMKQPRHLDAGDFVARHRFSCKPSLTSCLRLHFSKFSRPGEQTGLRAGKYRRPGGEASLIRDFDAPSQIDQAQQLTGPSSSSSRSNSPFPFSESHSITTLRGSTHFCLLRDTSSLCSASSFLQLPALLQHPPPATSSNVRIQFPNKRPVFQHHPLFANPRLDSFKFNGPSAVILLCPNSFQHTFVSPLAALWTSHYLFHCNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DIQ1</accession>
    <name>A0A812DIQ1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">VTI1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SPHA_53679</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VTI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003431">
        <property type="protein sequence ID" value="CAE1300175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DIQ1"/>
    <dbReference type="OrthoDB" id="430637at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15891">
        <property type="entry name" value="SNARE_Vti1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000078">
        <property type="entry name" value="Vesicle transport through interaction with t-SNAREs 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.400">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038407">
        <property type="entry name" value="v-SNARE_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007705">
        <property type="entry name" value="Vesicle_trsprt_v-SNARE_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230:SF26">
        <property type="entry name" value="VESICLE TRANSPORT THROUGH INTERACTION WITH T-SNARES HOMOLOG 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230">
        <property type="entry name" value="VESICLE TRANSPORT V-SNARE PROTEIN VTI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05008">
        <property type="entry name" value="V-SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12352">
        <property type="entry name" value="V-SNARE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="209"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="240"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="270"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="310"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="343"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="517"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="11">
        <location>
            <begin position="441"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="393"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAE1300175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="541" mass="67179" checksum="C66FE885272D0445" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DJN0</accession>
    <name>A0A812DJN0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AAAS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_57230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003849">
        <property type="protein sequence ID" value="CAE1304666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DJN0"/>
    <dbReference type="OrthoDB" id="411991at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045139">
        <property type="entry name" value="Aladin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057403">
        <property type="entry name" value="Beta-prop_Aladin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14494:SF0">
        <property type="entry name" value="ALADIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14494">
        <property type="entry name" value="ALADIN/ADRACALIN/AAAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25460">
        <property type="entry name" value="Beta-prop_Aladin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Aladin seven-bladed propeller" evidence="2">
        <location>
            <begin position="218"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1304666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="559" mass="59747" checksum="5068A5A602623BAC" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DJP0</accession>
    <name>A0A812DJP0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_57632</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003891">
        <property type="protein sequence ID" value="CAE1305149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DJP0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1305149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="187" mass="23019" checksum="42F928BF4B18B260" modified="2021-09-29" version="1">MPVNFGSIPQFIFRFSIFCFRYFLFLYFFFFSFFFFHFLILFLSLSLFLFLFLYFFLSVFLFLILFLSFSLSLFLFLSSFLSLSLSLSLFFSFFFSLFRFLSLSFSLSLFLSFYLFLSLILFSLSLFLFLFLCFFFSFFLFLFLFLSFFFSFVFSLSLFLLIFLYLRLPLSFSHFIYFFFLLLSFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DK92</accession>
    <name>A0A812DK92_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_57889</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003920">
        <property type="protein sequence ID" value="CAE1305472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DK92"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="301"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1305472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="367" mass="41228" checksum="A71D67BA2625E525" modified="2021-09-29" version="1">MSVCLFSLSLFSLSLSLSLSFYLCLFLPPPYYSISLSLFLFSCLSISSVFSALSLSLCFPSSLSLSLSLSLSLSLCLFLPLLIILFHSLYFYFPSVPIYLSIYLSILQLVTFNLICSYLSINLPIYLSIYLSIYLSIYLSIYLSESVRVYQITSLFASLHSLCFSTLKSVSTISNSLILPIFLTFTFSQSHSHSRYLSIYLSIYLSIYLSIYLFPFLYNSQFLTALFFLFSSLSLSHSHILTLAIHLSIYLSIYTYFFIFLPFFIPVNFSLGVIIVISPSFQFLPLSLSLSPSLSLSLSLSLSHCLSIHLYPLSASLFLLSFSTFSLAPSVCYKLHPLFSFAPLNALFLSLSLSHSLTPPTPVFSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DN62</accession>
    <name>A0A812DN62_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_56991</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003813">
        <property type="protein sequence ID" value="CAE1304399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DN62"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1304399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="230" mass="28505" checksum="46312476DF7597AE" modified="2021-09-29" version="1">MLFFYLPVLFHFIIFCFIVYRIISIFPILVFFVFVLLSSFFYSFLSLLSDLHFFFLHLPFSSFFSLFNMLSFLRHFFIFFFLFLWSFTFPFTFFILIMNYNNLKIFILYIEFLFLLIILSFYFLSFFLSFFLSFFLSLLLFLYRYFSNTNLKLILFFNSSHDFNKCIIYLSIYLSIYLSIYLSIYLYRESLNYKYHFSFVLYIYIYIPLFSLSIYLSIYLSIYLSIYLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DNF7</accession>
    <name>A0A812DNF7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_57172</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003842">
        <property type="protein sequence ID" value="CAE1304591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DNF7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1304591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="207" mass="25078" checksum="E906BDDC86D2B51C" modified="2021-09-29" version="1">MFLSKSSDSNSTTPSSSFPLFILQIFFFSLFLLLLLSPFLSSFLFCLRYFFLFFFHLLLFSFPFRSILLLSFFLFIFLPFRCISFFSSILLFFPNFFILFLFLSFLPFFSFLFCVYSSSFFFYYFFLSRLPFSFSFFIPFFFLLSSLHSFHPSFSFPVFFLFFFFLCYNLSIFVLLFLQLIISFFGLFSFSFFHISCFSFNLLYFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DP11</accession>
    <name>A0A812DP11_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_55281</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003667">
        <property type="protein sequence ID" value="CAE1302899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DP11"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1302899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="212" mass="24183" checksum="B60FA3F894DEB2DE" modified="2021-09-29" version="1">MVSSGINLSPPPPPPRATTYYSPFLFFFLFFSPTLFFRLALSFSFFSSHSLFALPLCSTIVSYHHLLLFLASFSLQFSTVVAFSFFNNPLSLSSLVPYRHLALFLPPLSLSLSLSLSLFLPFFLFFSFCSFSSLLFFYLSLLLLPFFSSLFFSYSFSSSSICSLLLLLLFSFHLYNILPLHLFLFLLSFYSSLSSSSSFIVFVFFSFLLLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DPI0</accession>
    <name>A0A812DPI0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_57433</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003877">
        <property type="protein sequence ID" value="CAE1304930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DPI0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1304930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="275" mass="31994" checksum="44EF7448D42830CE" modified="2021-09-29" version="1">MEPDFYTPLSHPFLLPLSYYYFTHFFHSLSHTLILLFSLTLSQSFFATTYFPIPPPLSLSLSIYLSIYLSLSISHSLSFTLSLSLSSFILHSFSLLLLLLLLLLLIPSSYLYSSSSFLLLYFLLLLHPSFFSFFFFFIPSSLSSSSSPSFLLLIIILFHSFFFFIPSSSSLSSSSSSFLLLLLFILLHSFFSFFFFSFFIPSTYYSSFSFLLLLHPFFFFIPSSSSLSSSSFLHSFYLLFFFILFFIIPSSSSFLLLLLLFLLLLHSFFFFYYYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DR64</accession>
    <name>A0A812DR64_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_58790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004041">
        <property type="protein sequence ID" value="CAE1306558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DR64"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="295"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1306558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="320" mass="39160" checksum="196D025DD0CAE1BE" modified="2021-09-29" version="1">MITSSSSSCSLWFIYFFCFLSFLYSLFLFFSYYILLLFLFIHYLFSFSLLLFLFFFSFMLFSFFLFLFFFSFIIFYTFACLFLFCHVSLSFTIFDFLCVSFSFVVFFFLLFISFFCASFFTFFFFLLLSFFPFFFVVHFLFLFACFFFSVYLTFTFSFLFLFSLFICRSISFPFFSLFIYRSLSFHFCFFFSLFLFLSLYFAFFFCFPFCVFTSLTFLPFFFPIFLSLSFLICFFSSSFLLSFFLSSFSFYSYFESFYLFISVSIFSFHLFIFVHFFLIFVYIFTFPHFPSFLDFFLSFFCPIFLSLPLSSFCLFSLHLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DV57</accession>
    <name>A0A812DV57_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_61416</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004340">
        <property type="protein sequence ID" value="CAE1309729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DV57"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
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        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1309729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="308" mass="37997" checksum="715D02626535B29A" modified="2021-09-29" version="1">MLSLKDFQYVFIIFLLLFNLIIFSYFFLRSLTFSFFFHFFFFSSFLSLTFLFSILSVFIAFLFSFLSFLLLISIFSFTILRIFLLFFLVSFLISFVFFFIFYFFIHFLSYFFIFNLSIFLFILYLSFFLSLSFFFSPVFHFCFPSSSFVFPLFTLLFPSYYHIHLSFLMFFLTSHTSHCFPFLFFLHLYLFFIFFFIFSFFTHFLILICFLYNSIFLFFFFFSLNITLFLSFFHFSYFYVLILLNLIYFFTLLTISFFSSDLFFFLAFFLSTSYFFLFFQYHLIDFFFPFFSPLPLNFPILTFYLSYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DV91</accession>
    <name>A0A812DV91_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_63001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004513">
        <property type="protein sequence ID" value="CAE1311606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DV91"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="317"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1311606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="349" mass="40978" checksum="377E48379CA54242" modified="2021-09-29" version="1">MILAHKIYFLLLRLLHFYLSIYLSIYLSIYLSISVSLSIYHSVFISFYLSIYLSIYLSQSLSIYIYLSLSIYRSISDYSNLQIDIIHKLPLCSGERHYLSIYLSIYLSIYLSISLILISLRFGSYLSIYHLVHLYLSAFLSSIYLSIYLSIYLSIYLSIYRSVYLYLGVFISIYLSIYLSIYLSNILFISISVFLYLLYPSIYLSIYLSIYHVHIYIVLFKTNQSIFLSIYLSIYLSIYLSVCLRLKYTRKRICFYLSIYLSIYLSIRLSVCLSVCLNIYLNLYISICTCLSIYLSIYLSIYLSICLSLYISIYLSIYLSIYLSIYLCSLLFICMPSFSNSFIPVIGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DVA2</accession>
    <name>A0A812DVA2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_61112</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004296">
        <property type="protein sequence ID" value="CAE1309401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DVA2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="357"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="387"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1309401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="432" mass="49786" checksum="55E1648870CB1ED3" modified="2021-09-29" version="1">MIRLSTCLYSFPSFFFFFSFVDIYFSFIFSICFSLLFSPPRRLVIASILSFLSFLPFSFLPLLFFPSSPSSPFLSFLPFSFLPLLFFPSSPSSPFLSFLPFSFLHLLFFPSSPSSLFFPSSPFSFLPLLPLLFFPSSLFFPSSPFLSFLSFSFLPSFLLFFPPSSPFLSFLFFSFLPLPSSSFSFLPLLPPFSFLPLLFFPSSPSSPFFSFLCFSFLPLFPSSPSSPFLSFLSFSFLPLLPPLFFPSSPFLSFLSFFPSSPFFLSSPSSPFLSFLSFLPLLSFHHIVSILVVMTLLHIFFFLGGVFLFFFFFIIISLLYCSPSFTFLFPLLIAYLFHFVSFDVFFFSCIPHLFPFFILSYFIFFIHFVSFSFSFSDCLILYSSFSDLSLLSFFFVSIPHIFLNLFFVIISSPMQPFQIVQIFLNTRSLHFCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DWS7</accession>
    <name>A0A812DWS7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_62203</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004425">
        <property type="protein sequence ID" value="CAE1310671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DWS7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1310671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="295" mass="33976" checksum="CBB9DD3B27C72586" modified="2021-09-29" version="1">MVDSGSSSQTNKLHRDLFESIYYLSIYLSICSSICLTYLKCAYISSSSSSSCTCSSFSSPSFPPPLPPFSSFFSLLSSSSSSSSSSSSSSSSSNPSTFPSSFFLSSFFFCLSFFLLFCFSFFIIFLSSFFLLSFSFFHLSFFLSFSFFFFHISFYIHYFLSFLLSFFPSFFLSSFLSFLLSFFPLFFLIHIFSIPLFSPSFLIAFILNILSLSYFLFFFFHCFHFKLKELFRKYNTHCLSLSLFLCLSVCLPFFLSLSLSLSLYLSIYLSISSFYRNLIFFHLFFYGQSDGPILI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DX24</accession>
    <name>A0A812DX24_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_63121</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004529">
        <property type="protein sequence ID" value="CAE1311765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DX24"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="346"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="383"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1311765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="409" mass="48693" checksum="AE2337E33D63E353" modified="2021-09-29" version="1">MTTTIAVIIIILIIIIKLYVIYSLSSFSFFSILYSSISFFLSFFLSFFLSSFLSFLNYVHHFLTLFMTFSPSFFLSFFLSFFLSFFLSFFLSFLNYVHHFLTLFFFSIFTLHSPVFFISFRDYIHDFLSLVLSFFLSYFFPSFFSILRPSHPYYRSFFFYIQITFITSLFLFEIIFMTSSLSLVLSFLPSFFFLSFFLSFFLSFLYYILFMTLSLFLSRSFSLSFFLSLTNEEDDDECIYIIIIFRLFFLHSTPDYIQHFYKCDDQTRSPANSVARATIIIILLKIFSFIISVIFLFVFLATKHFSVNIPINIAVLLIRLFATYYIVYIFYSILDSCDLQNITIYLSIYISIYLSIYHFLCLHFLSIYLSIYLSIYLSIYLSISILGCSHLSIYLSIYLSIYLSIYLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E0J9</accession>
    <name>A0A812E0J9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_64078</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004613">
        <property type="protein sequence ID" value="CAE1312892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E0J9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="308"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="332"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="376"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="403"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="432"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1312892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="452" mass="53384" checksum="B7D45C45DBBF0D0B" modified="2021-09-29" version="1">MIIYLSIYLSIYLSIYLSIYLSLFISIYLSIYLLFIIYLFICLCLFIIYLSIYLSIYLSISVSSFYLSIYLSIYLSIYPSIYQLFSFIYLSIHLSIYLSIYLSISCYLSISCYLSIYLSIYLSHFFHLSIYLGLFVIYLSLSLSIYLSIYLSIYLSIYLSIYPSQPRHIYLSIYSFIYLSIYSSIYLSIYPRVISYLSIYLSFIHLYIYLSIYLSMFSLLSIYLSIYLSIYLSSIYSFIYLSLFIYLSIYLFIYPVSFYLSIIIYPSIHLSIYSISVSLSIHSSIYLSIYLSIYLSQSLHYLSIHPSLYIYIYISHCSCLYIYLIVNIYLSIYLSIIIIYLSIYLSISVCSLFIYLSIYHLSIYLSIYLSLPKAQIFIYLSIYLSIYLSILYISIYLANYHRFFLSFFLSFFLSFYVLRISKTSHSLSLSPFFFLSLCSNSFCLLALSLSNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E2J0</accession>
    <name>A0A812E2J0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FBXL8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_63513</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004549">
        <property type="protein sequence ID" value="CAE1312220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E2J0"/>
    <dbReference type="OrthoDB" id="3219396at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.50:FF:000005">
        <property type="entry name" value="F-box/LRR-repeat protein 3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20872">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20872:SF1">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="52"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1312220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="409" mass="47255" checksum="403474D7622A8583" modified="2021-09-29" version="1">MPILVSFSSVAYSLCCRFKNCVSDVNPSCVTVAISLNFSLASKELIPSLAGTMDWSELPDHIIIQIFSYLPLFDRFNCCLTCKAWNQCFGASCLWQAMCFQFFSKNMSRSLQCLEKYGHFLKKVCIELDQSMDYNRINALKVMDFLSKIPNRRLTSLTIVFKSENPLFYAGKEFVEALKQLFSLPPSTDCDHKENNNFEMARLKEVNLSQLDVAYDNSVFDLLSVNHPSLEVLNIQNRVLVSKVTWDCMYRLVEQCLYLRELHVFHSSLSDEVLFLLAKQCRPQVFEYLSIKCRIDEKYHPDLTVEAWSAVTTAHPRLRVKLHFDHTCPQDRVLDIMQPVIPVVDLHLDTFTMLHNEVQRAGDYYSATLQITMLIATHHKYFIQSSTNFYTKPDMINKLNFPTINGVFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E2T7</accession>
    <name>A0A812E2T7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_67267</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004870">
        <property type="protein sequence ID" value="CAE1316543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E2T7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032538579" evidence="2">
        <location>
            <begin position="24"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1316543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="368" mass="41316" checksum="7786794CEF4CF387" modified="2021-09-29" version="1">MNKSPFPTRFVNLFLLPIELTLACHSFPFQLDDSPAVDISLSLSLSLSLSLSISLALSLSIYLWQFSYLSIYLLLCSYLSIYLCSYLDICLNLFISISVCSYLCIYLSIYLYFPSIPVCSYLSIYLSIYLSIYLGFFIYLSIYLSIYLSIYLSISSVPIFYLSILSIYLSIYSSACLSVCSSQSVHIYLSIYLSIYLSIYLSVCLPVCLFVCLSVYPSLFLSSIYHCLFIQSVFISFIYFSSIYLSICLSACLSVCLSVCLSQSVPIYLSIYLSIYLSACLSVCLSQSVHIYLSIYLSIYLSICLSVCLSHFLPLSLSLSPSLSLSLSLSLSLSLSRSLFCSSFFSSLSSHSFLFPPLSPEIISYELY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E498</accession>
    <name>A0A812E498_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_66325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004784">
        <property type="protein sequence ID" value="CAE1315401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E498"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1315401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="153" mass="18026" checksum="B59A584E365BD480" modified="2021-09-29" version="1">MSINTSDFILPERNLKMASFLIFFFFFFFFFFFFFFFFFFFFFCAPLKPLHFISVESTKVPILSSILPILLPTFSLSLSLSLPLTHRLSVSPSLSQFFHSLLSIYLSISVFTLSIYLSIYLVRKIISIYIFSTHIRLSMLNYKNSHCLSVYIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E6E1</accession>
    <name>A0A812E6E1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TECPR1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SPHA_67939</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Farmed</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TECPR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004929">
        <property type="protein sequence ID" value="CAE1317371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E6E1"/>
    <dbReference type="OrthoDB" id="72441at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098588">
        <property type="term" value="C:bounding membrane of organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006624">
        <property type="entry name" value="Beta-propeller_rpt_TECPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006614">
        <property type="entry name" value="Peroxin/Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010482">
        <property type="entry name" value="TECPR1-like_DysF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051513">
        <property type="entry name" value="Tectonin_beta-prop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23250">
        <property type="entry name" value="DYSFERLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23250:SF1">
        <property type="entry name" value="TECTONIN BETA-PROPELLER REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06462">
        <property type="entry name" value="Hyd_WA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06398">
        <property type="entry name" value="Pex24p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19193">
        <property type="entry name" value="Tectonin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00694">
        <property type="entry name" value="DysFC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00693">
        <property type="entry name" value="DysFN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00706">
        <property type="entry name" value="TECPR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Peroxin/Ferlin" evidence="3">
        <location>
            <begin position="61"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Peroxin/Ferlin" evidence="4">
        <location>
            <begin position="135"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Peroxin/Ferlin" evidence="3">
        <location>
            <begin position="830"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="domain" description="Peroxin/Ferlin" evidence="4">
        <location>
            <begin position="902"/>
            <end position="935"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAE1317371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1172" mass="131906" checksum="F84392B0D126F4B5" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E980</accession>
    <name>A0A812E980_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_69180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005066">
        <property type="protein sequence ID" value="CAE1318712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E980"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1318712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="233" mass="27283" checksum="22D4C0D3995BAF57" modified="2021-09-29" version="1">MHISLFLSNFLSFSFPLPVFIFRCLSLINAHCVSNSLSFSSTIFLMTILFSLSLSLSLSLSLCFLCSFYSSFSLLFFSVFLFSLSLSLSLSLSFSLPLSLFLFPFFSRHYFSLKVSIRISACFFNVQTVQSLKFFFSFNQLNYLSFFFFFFFFTCQSFKFFPNESYSYKILKYPHVISFCISVILFSPFFFYLYFLITTNASLSGDVVTEGRILRMSDFDEKNKRRARFNSKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EBS4</accession>
    <name>A0A812EBS4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">EIF2A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_70530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005166">
        <property type="protein sequence ID" value="CAE1320273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EBS4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1320273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="268" mass="33016" checksum="4E75B884872BC41D" modified="2021-09-29" version="1">MLFHNLHSFLSFLFLYNIQIIPSTFFVRFCFLSYACSLSVIHLSFFLYCLFRCASFLLPFLFVFYFLFSLQVLSAFFLSFSLFIFFLIRTYIRYFFSFFIAFFIFIIALSTFQHSIFLYLSSWPLLFRSLFYRFLLSFSSFSFIVSLHFMFLFFLHLKQHFFLSFYSFLSLFAFSSKLLPFFYLYFFFFFFISPSLFLFLSHFCFFFCLFVFRFLFFCCCFFFWLQKQTLLFYIYIAYRLINLSTRPMFPFGTGPRLLIHRLFFNFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EBU1</accession>
    <name>A0A812EBU1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_69763</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005103">
        <property type="protein sequence ID" value="CAE1319376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EBU1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1319376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="168" mass="19545" checksum="2C754AFA9FA726F6" modified="2021-09-29" version="1">MFFPSFCFFFLLSLRFSPSFSSFLFHILCVAFFFMFLYLYLSPTFLLHLHFTFSLPFFSFFPSLFLFFPSLFLFFPSLFLFFPSLFLFSPSLFLFSFPFSTLTSMFFISMSSFIQVVLFLFSLSLSLSLSLSLSLSLSLSISLSFLYSSSPIFSFLSSLFFTADSLLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ECA6</accession>
    <name>A0A812ECA6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_72430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005323">
        <property type="protein sequence ID" value="CAE1322477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ECA6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1322477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="323" mass="38993" checksum="3BFA7244AD6B11A0" modified="2021-09-29" version="1">MLLRFQNKTFFPPHSLSPHRLLSLPSPSSLSPPLSHSLFSSLPPLPSLSPALSFPFSLRVCCGKSCLFSCLHNMFIFHFHSFTIFFLFIFHLLSFFLSFFFFLSFFLSSFFLSFFQHYVIFSFFFLSKFYFSLFVCLFLNLLIFFIFLFLSKCAYFFIFLFSCFLSFKMYLFFFIFLSFEICLFFFLSKFTYFSSSLFLSFKVCIFFVLHSFSLFVLYFYFLLHFSSILSLFSLSFLSSSIFNYFFLSFFFLSFFFLSFFFLSFIICLFFISFSFSVFFILAPFFLFFLLLHVFFLSFIFPFYFSLSHILFFVNIVLHYIYFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EG41</accession>
    <name>A0A812EG41_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tyrosinase copper-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SPHA_73816</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Farmed</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tyrosinase family. Hemocyanin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005396">
        <property type="protein sequence ID" value="CAE1324004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EG41"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF126">
        <property type="entry name" value="TYROSINASE-LIKE PROTEIN TYR-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="6">
        <location>
            <begin position="92"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="191"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="194"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="209"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAE1324004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="237" mass="27463" checksum="AC80E9577279806D" modified="2021-09-29" version="1">MFSADFVGNGRGLVNTGPFRGWNTPHGLLRRNIARGGSLMTSRDERNVMSRFHLEDITFPNAPNWTNVEEMHNQVHVWIGGQMRRIESACYDPMFWMHHAYIDCLWENFREKQKANGIDPSSDYPEFSFGQRLHAPNSRLGFGWLLIRHAIHEYFSESFYRCAATPTCSRQRPSCGSEWLQCDFRQNRCMSRPADSSSTNQQRQVPSIRSNSGSTSTGRGRFSSNSRRRTSNRWWNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EH70</accession>
    <name>A0A812EH70_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MMP14</fullName>
            <ecNumber evidence="1">3.4.24.80</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_70839</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.80" evidence="1"/>
    <dbReference type="EMBL" id="CAHIKZ030005183">
        <property type="protein sequence ID" value="CAE1320592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EH70"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1320592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="221" mass="25267" checksum="BDB94ED422E720A3" modified="2021-09-29" version="1">MEVQSEGFSRGRPNIQCICQIITVHGVQSRREQFSAFVKSLNSSGSSEGEQAEYTVHLSNHNSSWKFSQKGAEAEYTVQLSNHNSSWKFSQKGAEAEYTVHLSNHNSSWKFSQKGQRPNIQCICQIKQFMEVQQSNHSWKFSQKGAEAEYTVHLSNHNSSWKFSQKEQRPNIQCICQIITVHGSSVRRAEAEYTVHLSNHNSSWKFSQKGRGRIYSAFVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EJG8</accession>
    <name>A0A812EJG8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_73652</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005382">
        <property type="protein sequence ID" value="CAE1323811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EJG8"/>
    <dbReference type="OrthoDB" id="6282070at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1323811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="185" mass="21081" checksum="8E96337054BC4ACD" modified="2021-09-29" version="1">MRVILSVCLYVCMYLSIYLSIYLVRSFHIYVSVYLSVSTYEFISICSLSVSIYLSIYLSIYLHQCIPVKLSAHITLSFTLSRSLSLSLSLSFYLSILSCSYLFYPMYLNQFVPVSNCLSVSLSLYLSCIPVNLSVHVSLSPLSLSIYVPISPNEVISIYLSIYLSIYLSQSVHFYLSIYLSIYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EM40</accession>
    <name>A0A812EM40_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_76187</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005483">
        <property type="protein sequence ID" value="CAE1326617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EM40"/>
    <dbReference type="OrthoDB" id="6379279at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1326617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="243" mass="28665" checksum="2BF9C81077DE19C0" modified="2021-09-29" version="1">MLTTLVNFAFIVNAEEGVKCHRNKDLGDRPANVYYCKDIEKSQCCHLGGSSYGCCVPHLTKEIKDQIRLWGSIILIIAVIIVVCFCCWKDVNYCDFDRPLKDYFCTNFWNFLFSTHFLFSSLLLYFSSSLYLCLCFFFLSYPILFNFYIRLYYHFLLLSFLFFLSLFYLFLSFFLYFLSFFLSSFLLSFFLSFFQLPNVQQSCSFTFYTNPFNKRLPSRASLFLHGVQCKHARVQDANTLPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EMB6</accession>
    <name>A0A812EMB6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_77199</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005507">
        <property type="protein sequence ID" value="CAE1327777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EMB6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032881879" evidence="2">
        <location>
            <begin position="24"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1327777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="240" mass="27884" checksum="FEF69D68CA2656BB" modified="2021-09-29" version="1">MLVVLFIMALLFIMLISIPYADALSVNLLVYSDLICSLSFSSQRHRSFKGGGLEFHEYGVTGRQGVVTRGRQKYYMCVERTICLPISLFLSLSLSLSIYIYIYIYIYPSIRYLSIYLSIYLSIYLSIIYPSISLSSYLSIYLSIYLSIYLSIYLSIFYSHLSIYLSIYLSIYLSIYFSLFMSIYLSQSIHIYLSIYLSIYLSIYLSIYRSLLISIYLSIYLTIYLSKRYDPSGDTLTSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EQP2</accession>
    <name>A0A812EQP2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_78330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005535">
        <property type="protein sequence ID" value="CAE1328695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EQP2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1328695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="258" mass="30324" checksum="E2288D3A59D181D6" modified="2021-09-29" version="1">MIYLSIYLSIYLSIYLSIYLCSLSLVLSIYLSIYLSIYLSIYLSIYVRYLCLYIFLISISVYIYIFLISIPVYLFECVIYLSIYLSIYLSIYLSMCFLSMLNLSFLCRRLSLYFFLFLAFFLFSFFLSPSLSSLISLSLSLSLSLYISISLFSSPHIPFLYSCFSLPDFSLSLLFFLSPSLSSLISLLLFLYIYNSLSFVLTRTFIDRIFVCFPFIHSPGFLDSFFLFSFLFPISFLFSFFSSEPLIQFFFHSVHTYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ERY9</accession>
    <name>A0A812ERY9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_75936</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005477">
        <property type="protein sequence ID" value="CAE1326341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ERY9"/>
    <dbReference type="OrthoDB" id="8960888at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="821"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1044"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="821"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="843"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="870"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="898"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="930"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1048"/>
            <end position="1082"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1326341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1212" mass="139561" checksum="7466D8839BDB242E" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ESP6</accession>
    <name>A0A812ESP6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_79227</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005562">
        <property type="protein sequence ID" value="CAE1329843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ESP6"/>
    <dbReference type="OrthoDB" id="10217289at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1329843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="229" mass="26065" checksum="3A9C6ECA57378F25" modified="2021-09-29" version="1">MLVKDYSHDDQGHYFHDDEGPCSPDDQGHCSYDDQEHCSHDDQGHCSHYDQEHCSHYDQGHYSHDDEGHCSPDDQLDCSYDDQEHYSHDDQGHCSPNDGHCSHDDQGLCSHDDQGHCSHDYQGHYSHCDQGHYSHCDQGHYSHDDQGYCSHDDQGHCSHDDQGHCSPNDGHCSHDDQGLCSHDDQGLCSHDDQGHCSHDYQGHYSHYDEGHYSHDDQGHYSHVGQGLFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ETC8</accession>
    <name>A0A812ETC8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_76677</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005495">
        <property type="protein sequence ID" value="CAE1327147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ETC8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="296"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="335"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1327147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="368" mass="42704" checksum="633715E1DEA35BD4" modified="2021-09-29" version="1">MSVLIIIHTTLNPIHSHILPCCCVFSLPLILFYYDFLSLHHPYIVRFFSFVLATHIFSPLFLSFLSAFLFISPFRHLSLILSLSLILSLSFSLSLSFSLSLFLLFFFSLLFRHFFLFSLSAFLFSLSTFLFLSSLSAYLYAFLLFLLFFFSLLFRHFSLLSFCISFFSFDISFSLFLFCFSFSLFSFLFLFRHFFYILFRHFISLLSFSFSFSLFSFDISFLSSLSPFIFLSSSPKTESHFPFLFLFYFSFFRPLLALLFPFNIISFFLLFAFPLSFSLNHSLSLSLSLSLSSSQAYLHFLFLLPFIIHISLFSLIAIITLFFSSSRLLLSSLSLSLSLSLSLSLCPSFFTFLGGHTFVMTCPLFELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EW32</accession>
    <name>A0A812EW32_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_79698</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005575">
        <property type="protein sequence ID" value="CAE1330418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EW32"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1330418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="185" mass="21440" checksum="B7B999A7BCE1E79F" modified="2021-09-29" version="1">MFVTIYLSIYLSIYLNLPQPKPVYNFLSQLVNIYLSIYLSIYLNYLVRNLSIYLSIYLSIYLSIYLSIYLLHIKAFISIYLSIYLSICKTLHIYLSIYLSIYLSIYLSTSYKSLHIYLSIYLSIYIFSCSKRFCQTSILFTALLNDGCLPHGRAGCRARWFAPVRRSKDKASSVPAARVMQAAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EWK7</accession>
    <name>A0A812EWK7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_80730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005609">
        <property type="protein sequence ID" value="CAE1331539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EWK7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1331539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="234" mass="27815" checksum="C1B4C9BAAC30550F" modified="2021-09-29" version="1">MLSSPFLWPDPFFLFLSFFLSFFLSFFLSFFHKCLSFPCFSCTICFLLPFFGLTHSFFLSFFLSFFLSHVPLFLFFPHPYTFFSFSFFLPHSFFLSFLSFMCLSFSYSSRTICFLLLFFFLPHSFFLSFFLSHVPLFLLFFPHHMLSSPFLLPAPFFLSFFLSFTSASLSLVFRAPYAFFSFSFCQPIFLSFFFLSFFLSKCLSFPCFSCTICFLLPFLFCLPHSFFLSFFLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EYA9</accession>
    <name>A0A812EYA9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_80894</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005612">
        <property type="protein sequence ID" value="CAE1331734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EYA9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1331734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="185" mass="20864" checksum="E0725DE8257EEF17" modified="2021-09-29" version="1">MSSPSRVTDADVHACSRTHAFLFSLSLSLSLSLSLSTDVANNIDVTYIYVVCVCRCVHIYLSIYLSIYLSIYLSILICSYLSIYLSIYLSPFAYIWLPLYLSLHAIITEDASLPLVDSSTHTHSRIHEHPNPRSNGLLHRLSPNLLWHLLPPFLLYTRRRAIAATAATLVEVPDPLHLYTMFGVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AKN0</accession>
    <name>A0A812AKN0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_199</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000002">
        <property type="protein sequence ID" value="CAE1138321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AKN0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1138321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="377" mass="44257" checksum="00833E234C9D349C" modified="2021-09-29" version="1">MKLLDRSIDIYLSIYLSIYLSIYLSQSVRIYLSIYLSIYLSIYLSIYLSILLISTYRVRWVNYDNLSIADCIYVNLFISIYLSICLSHLVHIYLSIYLSIYLSISVSSYLSISFCSSIYLSISLSIYLSHLVHIYLSIYLSIYLSIYLSLFVSIYLSIYLSHLVHIYLSIYLSIYLSIYLFQSLRIYLSHSAHLSIYLSIYLSIYLSIYLSICLSVYLFICLSISFGSYLSIYLSIYLSISVSSYLSISFCLSIYLSISFGSYLSINLSIYFSLFVSIYLILLIYLSITHIFNVQFIHSFLSIYLSIYLSIYLSIYLSIYLSLFVSIYLSIYLSIYLSIYLSILLFTCFIFLNYLFVLSFFHCLSFYYNTLFIYFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ALF2</accession>
    <name>A0A812ALF2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_1266</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000035">
        <property type="protein sequence ID" value="CAE1143360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ALF2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1143360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="331" mass="37230" checksum="DE3A49DB94A61FFB" modified="2021-09-29" version="1">MVGKRTPVLPQRTLCISPSTFPPSLIVTVDDLLKGCYQFTAAEWRGTVQRGKKKGNIYLSIYLSIYLSIYLLNAYLFSMNLRVSTYISFYLPTFYLSIYLSIWDNSINRPTSLRCVTILPAEPPLNILTLRFQTLCASPNPTSHTEIRPDSLFTSLSTNLFNLSLFLCLSMSLSIFVYLCKSLSVCFSLSLILCEFVYSYLSNCGFLSLYVSIYRSMLVCVCLSHNLLQSLSLSLYLFSLSLNLYLCETQSVLLSPPLCKTQSVLLSPPLCKTQSVLLSPPLCKSQSLCFTSQSPTSLFLFHSFSISVHAHSLSLSLSLSLSLIYIYEKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AMR3</accession>
    <name>A0A812AMR3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_1737</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000049">
        <property type="protein sequence ID" value="CAE1146052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AMR3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1146052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="286" mass="32647" checksum="F5639CC833D27F23" modified="2021-09-29" version="1">MIITVICLLLFVPFFHLVLLSFFSFLPLFYFVSLFFYCLILYFLGMYIFSFVSLSQNSHSILFSSISFNYLFFCLSLSFTFSSLSLSLSLSLYLSLSLSLSLSPTFLSFFFLPSLSLSLSLSLSLSLSLSTLYNKILSIVDWQIQLNITLFGSSSYILLLLYSISLSLSLSLSLSACFNQLSSHPKTILSLFPLIMKLLSFISFIMKPFFPSHHKGSLSFFHPEFNVFLSFFIFLKFFSFSSHPLLYTFCSSSSCLFLFSFILKISFSFCVYLSLLILFSFSSFPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AN06</accession>
    <name>A0A812AN06_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_2219</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000062">
        <property type="protein sequence ID" value="CAE1147750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AN06"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
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        <location>
            <begin position="74"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
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            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1147750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="276" mass="33239" checksum="E204140E350B9D3B" modified="2021-09-29" version="1">MRFARSFLLYLHSSLNPSVRFTAKIHMTQRKLPSSFPSAIISIFFVLPIFYSLFSCLPCRLLSSVVDLRPANSIYLSIYLSIYLSIYLSIPVVSFYLFIYLSILYFLSLRSPISLSLSIYLSIYIYLFFVPWFFLSFFHHYTKRLLFLLFILSFHLLLPLLLLHIKIFPLPFFVSFFFFFYFFHMFLLSIVPWFFLSFFLSFLITLQVLFFFFSSSPFFFFSSSSSFSSCFFFFFFFFFLKSPLSFFSFLSFFLSFFLLFFSFFLSSFFFSFFLFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AQE4</accession>
    <name>A0A812AQE4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_3560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AQE4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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            <end position="40"/>
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        </location>
    </feature>
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            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAE1152762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="218" mass="25636" checksum="8CCEA5AAD4C8139B" modified="2021-09-29" version="1">MVISLYSSQGDDDDDDDDVDDDDIYLSIYLSIYLSIYLSIYQPGCLYLSIYVSIYLSLLTSIYLCSICIYLYIYLSMHFDILITIFIRVYILMKNSQIRLFISIYLSIYLSIYLSIYLSHLLTSIYLSIYFPYLSIYLDILITIFILVYIFMENCQTRLFISIYLSIYLSICLSLLTSIYLSIYLSIYLSIYYRCPYLSIYLSIYLSQTFLLSVSPSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AQJ6</accession>
    <name>A0A812AQJ6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_3169</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="CAE1151544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </feature>
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            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAE1151544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="257" mass="28333" checksum="371389DBDF04E68B" modified="2021-09-29" version="1">MGIIAFAVYYMGIIAFAVLDIGIIAFDVLDMGIIAFAVLDMGIIAFAVLDIGIIAFAVLDIGIIAFDVLDMGIIVFAVFYMGIIVFAVLDMGIIAFAVLDMGIIVFTVLDIGIIAFDVLDMGIIVFAVFYMGIIAFTVLDMGIIVFTVLDIGIIAFDVLDMGIIVVQPIYLSIYLSIYLSITANTYISQSIFIYLSIYLSIYLSITVNIYLSTYHSQYLSIYLSIYLSIYLSIYLSKSISSYISVTIYIYLSIYLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AQZ3</accession>
    <name>A0A812AQZ3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
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            <authorList>
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                <person name="Bekaert M."/>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="entry name" value="OS08G0543275 PROTEIN"/>
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</entry>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000263">
        <property type="protein sequence ID" value="CAE1164745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AYM5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1164745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="242" mass="27605" checksum="255FC3F27DF740F5" modified="2021-09-29" version="1">MWFPLIKNYHNSHFFLCLSFHRPVVFRCPLSLSFVLPYLCLSFHRLFVFRCPLAFNIPSVSLFLTPPFAFCCLPSLPFLVSFLCFLLSSNLPSMPPLFVFRCSVPLSSVIPTLLSFVVPFLCLSLSPSFVFRCRLPLSFVVPFLCLSLSLIFFFCSRSLLSRLSIYLSIYLSIYLSIYLSISPIIIQRSVQCQMSKEPRGVVKSIVQKKTVKASQRHCRYGKADFSFDVTATTACSSPYPIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AZ43</accession>
    <name>A0A812AZ43_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_7026</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000225">
        <property type="protein sequence ID" value="CAE1161872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AZ43"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="363"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="403"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="437"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="463"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        </location>
    </feature>
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            <end position="584"/>
        </location>
    </feature>
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    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="786"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="815"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="851"/>
            <end position="872"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1161872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="895" mass="106536" checksum="0AEA7D08610B0340" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B1S8</accession>
    <name>A0A812B1S8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SLC16A12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_11230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
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            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000371">
        <property type="protein sequence ID" value="CAE1170758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B1S8"/>
    <dbReference type="OrthoDB" id="410267at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF284">
        <property type="entry name" value="EG:103B4.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
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        <location>
            <begin position="5"/>
            <end position="25"/>
        </location>
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            <begin position="37"/>
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        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAE1170758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="443" mass="48412" checksum="3C2CE0BB7D16ADFF" modified="2021-09-29" version="1">MVAAFFVQFIVCGITYSMGIFHVVFRNIFAGSQFDTSWVAALLFHVTAISSVLFRFVTSKFGCRISVILGGILSTAGLALGVCVTELYEVYLCMGVLTGIGFGIACSPSIVAIEQYFHKCRYQALSTVLAGIGCGIIVFPIIVRYLLEEYAWRGTLLLLSASTLNLCVCGAVMKPLKCEKEVRLLPLLSCLPLRNPLFYAMCIANLFWSFGSTIIYLFLPSYAISMGTDFSTATFLVSCIGMASFTSRVIFAFMGHNSTLDDVTAILCSLGLGGFWTTFMSQVTRELLGPHYIAIGNGYLSFMIALGCLGGPCAALLIQAEDEYKYAFYLAGACLLTSSTIMVLFKYRQCGVPVSLPSSEVKEPLMNAQNGAAKYADSTTTYRYYDEEHMVMQTPGVYSLPASTDARLELRGSRDKCLTHITTTGIYCTRKPSPITDQTRVCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B1Y3</accession>
    <name>A0A812B1Y3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_9134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
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            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000293">
        <property type="protein sequence ID" value="CAE1166959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B1Y3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="303"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="334"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1166959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="358" mass="39201" checksum="CE079E9203E1B049" modified="2021-09-29" version="1">MISISFRNFKLRPNFDGGSGFFSRITLSLSLSLSPFLSSSSPFTLVSSRSENIYFIPLFHTSSSLITRSSSLSHSLFSNYFNPSFALLTLSLTFSYIVLLITASPSLFHSYSIFSIFLSLSLSLSHSLSLVSLSLSLPLSHSLYLVSFSLSLSLSLWLVSLSLTPFLWLSLSLSHSLSLVSLSLSLFHSLSLSLSLSLSLSHSLSLVSFLSLSLSLSLSVVSLSLSLTPFLWLVSLSLTPFLWLVSLFHSLSQVSFSLSLSLSFTPFLWLVSLSLSPSVVSLSLSHSLSLFSLSLSLSFTPFLWLVSLSLSLPFSGYYSLILFLPLLHSRPLSLFLPILFPRVPATPSLSLSLLLLFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B2Y5</accession>
    <name>A0A812B2Y5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_10099</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000325">
        <property type="protein sequence ID" value="CAE1168567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B2Y5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1168567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="228" mass="28044" checksum="A77AB8F490EF539F" modified="2021-09-29" version="1">MSFFFILFSFLYSFFFSFTVFLFFYLSLIHFFHSYLPIFFFFCRYLYIIHFQLNFIHVPASYFFLSLPLFLFFSVLHDVLSFFLSFFLSFFFFLSIFLSFFLYFSFSIFLSFFLSFFLSFMRPSRLFLFAHKYNDICSFKACPLSLSSPLSTQIQLQSERYVCLKPRRRNWLIMLSSSVFHFILFPFFIVSNQFDLYPSFFLSFFFSFFLYEFLYEFLSFFVNIFLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B7L1</accession>
    <name>A0A812B7L1_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SPHA_12470</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000416">
        <property type="protein sequence ID" value="CAE1173105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B7L1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="215"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="326"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAE1173105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="354" mass="41380" checksum="507B585D30602AF6" modified="2021-09-29" version="1">MAAAVTKAIERSSVSFPLYCFLSLHSSLFLLIYSLYLSIVLFFSLLFCLSLGLSFYLLLSLSLSHYIYYSMSIFCYYSLYIYFFSLKSYNSLFLLFSFCFYRALSSFLLVFFSLITSSSLLSSLTFVIILSLSLSLSLSISSLSLSLYCLVFLSIVLYCFLFLFLYFSFSLSLPLCIPCYLISCIIISLYLSIAFFFLSNFLTIYCSIFLALSRFLYFFLSFLSCFLSFFLLLSFSFFFSSQFYLFLIFSDSPLYFSYLFLFTLSFSFFLSFLSFFLAFFLSFSSFLFRFSSLLSFISFLYFLILLFISLTSSFSRFHFLSFFLSFFLYCPLFFYFPLLLSIAISIYCSLSFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B7N0</accession>
    <name>A0A812B7N0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_12468</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000416">
        <property type="protein sequence ID" value="CAE1173133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B7N0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="150"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="208"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="284"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="308"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="343"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="370"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1173133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="411" mass="49708" checksum="EFC498C77A96200D" modified="2021-09-29" version="1">MFKIYKYNLSIYLSIYPYGRSIFIFSSGSIYLASLYLLDYLSSLSLPDLSIYLSIYLHYLFWIHLSSLFFWIYLSIYLSSLSFLDLSVYLSIYLHYLFWIHLSSLFFWIYLSIYLHYLFWIHLSSLFFWIYLSIYLSIYLSSLSFLDPYIFIIFLDLSIYLSIYLSIFIIFSGSIYLHYFLDLSIYLSIYLSSLSFLDPSIFIIFWIYPIYSSIYLHYLFWIHLSSLFSGSIYSSSIIFIIFSRSIYLHYFLDLSIYLSIYLSIYLSSLSFLDPYIFIIFLDLYIYLTSLSFLDPFIFIIFLESIYLSIYLITSGLTILFISFGSIYLSIYLHYIFWIISLRYLSWIHLFSLPFLDPSIFLIFRDLSLHYFVWIYLSIYLSIYLSIYLSIYLSIYLSKTLKKRERDMLYIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B7X8</accession>
    <name>A0A812B7X8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_10839</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000355">
        <property type="protein sequence ID" value="CAE1169963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B7X8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="143"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="298"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="351"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="380"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1169963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="405" mass="49138" checksum="3A50BE11E73983BF" modified="2021-09-29" version="1">MDVKEKFISICVYFVFFLPFYLCVFLSLYVYFSFFLSFFLSFYVFFFLYSCFFFLCVFLFFLFFYLVIYLYIFVLSMFFSIYLSIYLSIYLSIYLSIYLSILISMLFFLSFPVFFLYICSFYLSMYVFFFLLSVLSFYLSIYLSIYLSIYLSIYVFFFLCICFSLFFFSFFFPIYLCMCFSFCPFSFYLSIYLSIYLSIYLSIYVFFFHCICFSFFFLFFLSFFLSFFLYVFFFLPVFYLSIYLSIYLSIYLSIYLNDSVSIYLSIYLSIYLSIYLSIYLSVSLYISEMNKDNSPNNVNHLSIYLSIYLSIYLSIYLSIYLCLFSIYLSIYLSIYLSIYLSIYLSMSIQYLSIYLSIYLSIYLSLFSIYLSIYLSIYLSIYLSMSVYSVSIYLSIYLSIYLSIYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B924</accession>
    <name>A0A812B924_ACAPH</name>
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        <recommendedName>
            <fullName evidence="4">Dynein heavy chain</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">SPHA_12400</name>
    </gene>
    <organism evidence="2 3">
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        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
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            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000415">
        <property type="protein sequence ID" value="CAE1173033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
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        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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    </dbReference>
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        </source>
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    <sequence length="2069" mass="244790" checksum="FFDAE778BC0C7B6C" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B933</accession>
    <name>A0A812B933_ACAPH</name>
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        <submittedName>
            <fullName evidence="7">WDR81</fullName>
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                <person name="Bekaert M."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <subcellularLocation>
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        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1104"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1161"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1478"/>
            <end position="1487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1569"/>
            <end position="1579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1648"/>
            <end position="1659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1668"/>
            <end position="1683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAE1174186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="2073" mass="232947" checksum="043F27D1E247C237" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B9N8</accession>
    <name>A0A812B9N8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_15721</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000549">
        <property type="protein sequence ID" value="CAE1225446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B9N8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1225446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="273" mass="30947" checksum="A0C997B29674F397" modified="2021-09-29" version="1">MKARNSRLSFRIYDLSATPSELSIERKSLTLDLLERLVFLATHCRLSFVAVLLVALSASPEAAMTKNVLPIDPPRLRPTHLLKNQHNISACWPIYLSIYLSIYLSIYLSIYLSIYLSHSVTINLILLLYIYLSHSVTVYLSICLYSYLSIYLSISFCNCLSISVYSYLSVYPYLSIYLSIYLSIYLRKTNDGAAICSSSFTDAFFSWRNDNRSREKRTSPGRHGASLLISLHDNSIDALPVSSWFADKKKSKENQLDSNGTTSKTSVAIKRNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BB06</accession>
    <name>A0A812BB06_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">RETREG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SPHA_13372</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RETREG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000447">
        <property type="protein sequence ID" value="CAE1174986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BB06"/>
    <dbReference type="OrthoDB" id="10029527at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057282">
        <property type="entry name" value="RETREG1-3-like_RHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043384">
        <property type="entry name" value="RETREG1/3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28659">
        <property type="entry name" value="RETICULON-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28659:SF2">
        <property type="entry name" value="RETICULON-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24456">
        <property type="entry name" value="RHD_RETREG1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="RETREG1-3/ARL6IP-like N-terminal reticulon-homology" evidence="11">
        <location>
            <begin position="17"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="251"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="324"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="378"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="251"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="277"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="349"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="382"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="399"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="433"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF24456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAE1174986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="464" mass="52403" checksum="C67062043D0D3B27" modified="2021-09-29" version="1">MDSVSKQEEVLRTYLSPWEGWIMQIQSLLVWERPRWSILWFIALHLLFWFFCITDFSFYTLCCLFVMTALLIDVFMNKIWVKIKFRRHATADDSDAWTPVHLHLLSVPELCHMTSQFSSSLSSSFQQWLLFRREHPLQFFIVNTYICLNFAIVGCYIPGIVVSYLIGISVLLSPCLIYYRVPHKIYKKLEPGINRVCYVLSYFSIFITVFRAIRGDCGNNQPGIVLAADGTSDDLNLDDLCPDTDTAMLSAAASESEGEETPGPSTPALSENQSIENSEDEGHESDLEQDLAEGLGEEMPSFDDHTDDELLDSKSLLPDSMQFVPTHFEDSDSDDEGLTHNLKFSEVTPKGRDDIESERNIAGQLVAQAMGSMMKAAFQGLSSDTDNSNNDGSSSYAPRKSHKSKSSQKKTEYETTTVKPKNKKGRNSVSLEDYLEQSDTELADDFEFLDPTELEDVDNSTSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BEF0</accession>
    <name>A0A812BEF0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_15946</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000557">
        <property type="protein sequence ID" value="CAE1226264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BEF0"/>
    <dbReference type="OrthoDB" id="6066510at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1226264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="241" mass="26536" checksum="DEA6A022BE76A80E" modified="2021-09-29" version="1">MAAASVGIPILRQFDIYMPFEFIEKCVQLSCVGHGICWSGSVRDMTAGQLFQNHKNSKMENSGFEQWRLDNSSENVQLAHVQTCINPENMLLISFSKVQLQVLEGRCGFWLSNVQKDESSCAMSVYPINECSGVPDTDSYGVSTAATSLLLEVAKDGSTVHYFIQHDNTNDKGNQMDNNQQVIEDIASLLLVAEEASSKESLPMTSEQAQAVNEMQSKNAVVHFIPANVEDVNSSTVEVDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BGR1</accession>
    <name>A0A812BGR1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_16494</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000580">
        <property type="protein sequence ID" value="CAE1227653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BGR1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1227653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="257" mass="30422" checksum="B30AD53928C3AAD0" modified="2021-09-29" version="1">MQFLSQMSIFMRSIAPPHYIPFNKYSLPLSSLPTLNLLSISRLPLLHALAGPQLHIFDCFRSCLFHLLWRFFPHPYPFDSCQKFICLYCFIYLSIYLSIYLSIYLSIYLSISLSLSLYIYIYIYIYIYIYQHIYRLHHLSIIFLILILFLSLSLSLFLFLFLFLSLSCQHEFSSFYLPTSVSPPYLFILRYLLSVSFCYTLTRLINLFLLALSPSFLPIYLSIYLSIYLSIYLSIYLGCSYMSIYLHDSLASYHHLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BJ53</accession>
    <name>A0A812BJ53_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_19647</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000713">
        <property type="protein sequence ID" value="CAE1235116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BJ53"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1235116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="318" mass="38585" checksum="DBC0992312B98158" modified="2021-09-29" version="1">MKEKYDITSDNVRSRAKHRITSFQRKYCRFYFLLRAIYVLFTPSSSNSIIFDHLQDLLFVFFFFSSPLFFFCFFCLLLSIFFFHVCFFVCFFVSYIIQYILFFFFSFLFHLAHHPFSQFYLNFNLLFPIFINNFVSVFIFPCIFLISPFTFSSIPRFPFCLVLSFRPLHLFLSFYFLPSFLSSLIKLLFYSLIYLSSFFLSFFFSGYTYLLSLFLCLIVSLFLKIYLSSFFASFFFSFFFRSGCTYFLSLLLFFFLSYFLSYFLSFFLSFFLSFFLSFFLSFRIYLSSFFAFFLCKCIYLSIYLSIYLSIYLSIYLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BNY4</accession>
    <name>A0A812BNY4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_20163</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000739">
        <property type="protein sequence ID" value="CAE1236267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BNY4"/>
    <dbReference type="OrthoDB" id="8957827at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134:SF22">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134">
        <property type="entry name" value="OS08G0543275 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="302"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="334"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="390"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="434"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="466"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="500"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="528"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="553"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="576"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="612"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="669"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="695"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="727"/>
            <end position="758"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1236267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="759" mass="89970" checksum="02CD7508AD346B08" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BRU5</accession>
    <name>A0A812BRU5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_21014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000774">
        <property type="protein sequence ID" value="CAE1237950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BRU5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1237950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="247" mass="27196" checksum="50858BA58D886CE7" modified="2021-09-29" version="1">MLFHIWYSLTAVSSPSALKCCTQAVYALPYIPYPSSISLPFSLYYISLCSLSFLTCFLLFIPFPLLLVSLLALYLLLSLLFSSDISLFLITIFSFSSSFLALFSLLFLFLCFYFFSLPYIYIFLPPSSPLFELILYFYIFHTHSHSMSHFLSTHSCSIRLTPAVSSTLQHPAHSCSIRLTPAASGSPCSIQHSCSIRLTPALSSTPAASSTPAVSSSIRLTPAVSSTPAASSTSTVSDHLHFLFLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BSN6</accession>
    <name>A0A812BSN6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CCDC6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_23295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000862">
        <property type="protein sequence ID" value="CAE1242437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BSN6"/>
    <dbReference type="OrthoDB" id="78858at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019152">
        <property type="entry name" value="DUF2046"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15276:SF0">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15276">
        <property type="entry name" value="H4 D10S170 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09755">
        <property type="entry name" value="DUF2046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1242437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="445" mass="50987" checksum="C5FBEEE52051F698" modified="2021-09-29" version="1">MMADSASELESDTSSLDGAGGSGSGSSSMQPPSPAQVEQLLTKRIDSLQQENKVLKVELETYKLKCKTLQEENRELRKASVSIQARAEQEEEFICNTLLKKIQSLRKEKEALAMNYEQEEEYLTNDLSRKLMQLRQEKVELEQTLEKEQEYQVNKLMRKIEKLEADTLAKQATLEQLRREKVELENALEQEQESLVNRLWKRMDKLEAEKRMLQEKLDQPVSSPPSPRDMNNGDTAHNLAQHIEHLRAEVARLKQQLQAAQAEHEEKMAQYAQEERQIREENLRLQRKLQMEMERRESLCRHLSESESSLEMDDERHFNEMTKQYDMSSSHTVRPRTVSSPIPYASPNTSRPLSPAFSPPSPMRRNTPGSQPSFYTSTFLPGTSPPVFTHSPNVTVSNSPEDQSSFYPPTFLLGSSPPVFASDLTKPRPSPEKFVRPGNVPQDKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BVW1</accession>
    <name>A0A812BVW1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_23175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000857">
        <property type="protein sequence ID" value="CAE1242014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BVW1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1242014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="150" mass="17574" checksum="AAB63E2587D894C4" modified="2021-09-29" version="1">MIFVLYLFKTIGNIFFKISYLYLPCRLRALYCISLSLSLSLSLFLSLSLLLTAHQPASIYLSIYLSIYLSIYLSIFLSFFLNFPVIYLSTYQSISISRYISFVFILSIYLSIYLSIYLSIYLFQSINRSIFLCLSQFLVIYLPTYPSIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BWH9</accession>
    <name>A0A812BWH9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_25383</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000960">
        <property type="protein sequence ID" value="CAE1246903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BWH9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="20"/>
            <end position="38"/>
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        <location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="81"/>
            <end position="105"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="136"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1246903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="236" mass="27565" checksum="82A8A9D1E92E6FE4" modified="2021-09-29" version="1">MGSVVDFYSICSFPNLDIYLSIYLSIYLSIPASAHIYLSIYLSIPASAHICLLCSYLSIYLSIYLSQPLLISIYLSQPLLISVFVYLSIYLSIYLSIYIYIYIYIYIYIYSSLCSYLSIYLSYLLFLLSFIILIYFSYNLFFLSFFLSFFSGCFYALSSFLSFLSLLTLFNLFPLLIIFLSASLSFILLSILILSSFFLSFFLSFFLPSFLPSFLPFFLSFFLSFHFPRDQNYYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BZ43</accession>
    <name>A0A812BZ43_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_26303</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001004">
        <property type="protein sequence ID" value="CAE1248805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BZ43"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="285"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1248805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="316" mass="36584" checksum="38DCDCA2D9A11F74" modified="2021-09-29" version="1">MRYFSRGLFLRLGLSLSLSLSLSLSLAILSHSFLFLSQCLSVNHAHFVTLSVTTSYNFYLSIYLSIYLSIYLSIYPSLFIIYLSVGLSIYLSLFISIYLSIYLSIYLSMSICSYLFHPVHIYPSQPVHLSLSLSLSIYLSIYLSIYLSLFVSIYLSIYLSIYLSQSFISIYLQIDRFQYLSIYLSIYLCQSVPIYFILFISIHLSLFISLSLSLSLNLSIYLSIYLNVVISITVWSYLSIYLSIYLSIYHSLVITIYLSIYLSIYLSQFGYIYLSIYLSIYLSKIFSAFFLSSLLCSLFVYLSFLLSFFLSSLHRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C1V5</accession>
    <name>A0A812C1V5_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SPHA_25663</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000970">
        <property type="protein sequence ID" value="CAE1247382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C1V5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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            <begin position="239"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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            <end position="297"/>
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    </feature>
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            <end position="372"/>
        </location>
    </feature>
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        <location>
            <begin position="379"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="469"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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            <begin position="503"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="533"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="567"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="35"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAE1247382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="604" mass="71202" checksum="0695C20A2DAB0457" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C463</accession>
    <name>A0A812C463_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_32256</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001335">
        <property type="protein sequence ID" value="CAE1260287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C463"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1260287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="231" mass="27403" checksum="06FDB119A69976BB" modified="2021-09-29" version="1">MFFSLAHRIQLLSFFLSVISFSFFLSFFLSFFLISVTFFLISTFDYLSIYLSIYLVLVIYLSIYISILVCSYLSIYLSIYLSIYLSIYLSIYLILFISIYLSIYLSIYLSIYLHLFHCFLNEEEADDKPCQLISLSMSSFFLIISHFCFLLFFAFSISLSLLYFILYSFPLLFFFSSALSHSSVFLSPFYSHFFLLLSPLHFFFFINIFPLPIFSFLLRFLSLSMFVLFTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C7S5</accession>
    <name>A0A812C7S5_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Translin-associated factor X-interacting protein 1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SPHA_29984</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001202">
        <property type="protein sequence ID" value="CAE1256070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C7S5"/>
    <dbReference type="OrthoDB" id="2113814at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012331">
        <property type="entry name" value="Clathrin_H-chain_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032755">
        <property type="entry name" value="TSNAXIP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10292:SF11">
        <property type="entry name" value="CLATHRIN HEAVY CHAIN LINKER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10292">
        <property type="entry name" value="CLATHRIN HEAVY CHAIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13838">
        <property type="entry name" value="Clathrin_H_link"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15739">
        <property type="entry name" value="TSNAXIP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Translin-associated factor X-interacting protein 1 N-terminal" evidence="3">
        <location>
            <begin position="49"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAE1256070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="620" mass="71534" checksum="14BF9F2B9341FB60" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C964</accession>
    <name>A0A812C964_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NR4A2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SPHA_33551</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001405">
        <property type="protein sequence ID" value="CAE1263088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C964"/>
    <dbReference type="OrthoDB" id="5952118at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035259">
        <property type="term" value="F:nuclear glucocorticoid receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004879">
        <property type="term" value="F:nuclear receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071376">
        <property type="term" value="P:cellular response to corticotropin-releasing hormone stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003070">
        <property type="entry name" value="NR4A1-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24085">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24085:SF4">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR HR38-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01284">
        <property type="entry name" value="NUCLEARECPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NR LBD" evidence="6">
        <location>
            <begin position="164"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAE1263088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="423" mass="48140" checksum="B4AFA8243FFC8EEA" modified="2021-09-29" version="1">MLQPVYVVSRTRLDTNFRVIHALPSTVFSPKGLYHLIRLLDTSRLEEALTKEAAGNPLYPNSNCTKAHPYPPLLDLSHQTLIPKKLSFMSLSIPSLFKPCILCLFVHKSTESFVRSPFETQSLAFFFYRPSRQYTNFVRTDSLKGRRGRLPSKPKSPQESPPSPPVSLITALVRAHVDTSPDIPNLDYSKYKELSGEDSPTAEVDRVRLFYDILVSSVDVIKCWAEKIPGFHDLCKEDQELLFQSATLELFVLRAAYRVQPDSDKIIFCNGLVLHRLQCLHMFGDWINSIIEFGMSLHRMTLDISSLACMAALSMITLRHGLREQKKMEDLQMKIIDTLRDHCIYNSEAQKKPHFFSRILSKIAELRSLSREGLQRLFYFKLEDAIKAPPCLSFFLSSTISPSCPVLSLSLSHSLSPFPLQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C9C9</accession>
    <name>A0A812C9C9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_32583</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001358">
        <property type="protein sequence ID" value="CAE1261120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C9C9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1261120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="327" mass="38863" checksum="9E68F01E0B20C804" modified="2021-09-29" version="1">MVQLTSIYLSIYLSIYLSIYLSISVYSYSFQSINTISIYLSIYLSIYLSIYLSQSILTHFSQLIPYLSIYLSIYLSIYLSIYLSIYFRSTFSCLPFSSLSISIFLFVLFLVITPFLSFLFLFSLSSLSFFSFLFFSILHVPVLPLTFLYFSSIFLSFFLSFFLSFFLSFFLSFFLSFSMVFFFFAFHYSVSFPCLLLYFLLFFLEPFSFFLFLFFFFFLFFLHFFTFFVPPPIYSPPPFQIPLSLLISSLSSDYKDLILSIYLSIYLSIYLSIYLYRIRGATFDKRTKESRTTKSWQGRRTHQTQRSVTQQSISLHIYLSIYLSIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C9N7</accession>
    <name>A0A812C9N7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_31981</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001326">
        <property type="protein sequence ID" value="CAE1260039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C9N7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="307"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1260039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="377" mass="45022" checksum="263808689A816F75" modified="2021-09-29" version="1">MLFHFIRLFYPPPYSFLFLSFIPSPSISLSSIFSYSFLIYLSLFVFLPLSIITSHSCFLYLSISIYLSIYLSIYLSFFLSFFLSFFLSFLSLFYFYPSFVLSFFSFFLSFLFPLYHSHSIFLFLFLPFILSLFLHFSFFLSLSSLHYLPLRNTFCLSLYYFLSIFIPLFLFHSFFLSFFLSFFLSFFFFLNISIFPSLLFLLSLTFSVSLSTVLFHPFFIYRFLTFFCLLYYFFIPFFLSYSLSIFLSLYFSFFPSFSLSLSLSLSNLLYFSFSLSLSSILYLSLPISFSVLVLFPLYHYFSFSQSFVLSFFFFLFFFFLSYSLSIFPSLFYFLPLLQKRHPGSFSMSRIVANVNDCLYSPSDFLHSRFQRHLTIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CBF2</accession>
    <name>A0A812CBF2_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit gamma</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit gamma</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SPHA_32961</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Farmed</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on the eukaryotic initiation factor 2 (eIF2) complex gamma subunit. Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-2B gamma/epsilon subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001375">
        <property type="protein sequence ID" value="CAE1261914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CBF2"/>
    <dbReference type="OrthoDB" id="10250549at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002183">
        <property type="term" value="P:cytoplasmic translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04198">
        <property type="entry name" value="eIF-2B_gamma_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051960">
        <property type="entry name" value="eIF2B_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056764">
        <property type="entry name" value="LbH_EIF2B3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45989">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45989:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25084">
        <property type="entry name" value="LbH_EIF2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleotidyl transferase" evidence="10">
        <location>
            <begin position="16"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="EIF2B subunit epsilon/gamma LbH" evidence="11">
        <location>
            <begin position="371"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF25084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAE1261914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="469" mass="53145" checksum="FC2C2CA204355FC1" modified="2021-09-29" version="1">MFFTSREKFNRLAFQPVIMAAGTGSRMTDLTASIPKALLTVGNKPMIWYSIHMCQRVGFQDVIVIVLESKRTQIEKALKIPGDISIKIDFVGIPDDEYSGTADSLRRIKNKIKSDILVISSDLITDMKMEHMIESFMAYDADVGVLLSPLPKAFNETQAPGVKVKKQKEKDIVGLDKNERRLLFYSNEADFEDDITLKNSFLKKCPFVKLRNDLTDCHMYFLKKWIFDFLLDKKSMSTLKGDLIPYLINKQFVKPPQLEKKDNPYSTDSMEIGSYMSDVQKKDIFSYIPADIMAEAKKLSLSSSRPDNYLIHDEKILCLAYIQNSGFCVRTNTIANYAEANKQIYDHFEALAPDLKIQRVPKAYENLKTITKSLLGDNSSVGQNVIIAESVIGPQCQIKDDVKIKNSIILDHTIIHKGSKIENCIICDNAFICSMCDLKSTVVGSCRKIEESVKLKNETLVDAQEMMEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CCL3</accession>
    <name>A0A812CCL3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_35238</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001513">
        <property type="protein sequence ID" value="CAE1266607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CCL3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="266"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="332"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1266607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="393" mass="45197" checksum="88F0DF7E44F15F8D" modified="2021-09-29" version="1">MADKIFRIYLSIYLSPVHYLAISFSLFLISLSVSTCSLSIYLSIYLSIYLSIYLSHLFLISLSLSRPAHYLSIYLSIYLSIYLSILSRSSYQAFPIYLSIYLSIYLSIYFSPVHYLAISFCLFLISLSVSTCSLSIYLSIYLSIYLSIYLKPILIPGLNVYFKSIYLHQFISIYLSIYLSIYLSKPCSLSISFSLFLISLSLSRPAHYLSIYLSIYLSIYLSILSRSSYQACQTCNCRPRLGAGMLYINASNVYFKSIYLHQFLSIYLSIYLSIYLSPVHYLAISFSLFLISLSLSRLVHYLSIYLSIYLSIYLSIYLNLSILISIRPFISIYLSIYLSTCSLSLSLCLDLFIIYLSIYLSIYLSISVTSSVHIYLSIYLSIYLSIYLSIYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CDF3</accession>
    <name>A0A812CDF3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_35643</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001543">
        <property type="protein sequence ID" value="CAE1267564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CDF3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1267564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="331" mass="37709" checksum="0DCEB22CE41271B4" modified="2021-09-29" version="1">MRKRTVQLSDISSDTSHMIHIHSNLFPLHSFLSLYSPLIFLSIFTLAFLSLHSSHSLYLDTYTPVSRYTLPTHSISTHILQLSLPLPSNYLDTFTPVSPTLFPNYLDTYTPTLLHSSHQLSRHIYSRFSLHSSSNSRHISPTSRYLFPLLSRHIYSRFSSSSQLTLSRHISSNFSLHSSLNSISLYTPTSLYTLPTPLSRHSSSNSLSSLYTLLQLSVPPFSLFFTLSRIFLSILTLLFPSISLTFPFFAYSSFTVTFFSLSPYLIVSRYNLPINSSRHISPVSRTLFPKSSISTWKFKLELKRSALLYLDTHKINLNKSLKIPFHPVSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CFE9</accession>
    <name>A0A812CFE9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_36692</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001613">
        <property type="protein sequence ID" value="CAE1269699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CFE9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34723:SF7">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34723">
        <property type="entry name" value="PROTEIN CBG17025"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="332"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="356"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="431"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1269699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="451" mass="51592" checksum="7310D8AA4E4F62C5" modified="2021-09-29" version="1">MIKRFAESTSSELSFDVDNDMKQSPLAEKDRYYLSIYLSIYLSIYLSIYLSIYLLPFMIYLSIYLCWDLYQSFYLPVILNACYLRPSPFHIVTIISFPFLSPPPLSRCNLFVIPFFLPDFIPSFAESFLPSFPSSFFFLSFLLAFVPSAIPSLLPSFLPSTFFFLSFFLSFLFFPFFPPSFLSTVSASFLPPIRLPSFFLVFHPSFLSSFLPAILPLFHLPSFLLSQLFSVLPPNFFSSFPASFLLVRLPSFLPSFLLFSAFLPFFFPSFLPSFRPSFLPSFLASFLPVRLPSFRFSAFLPFFFPSFLPSFLPSVLPPSFLSSCSASFLPSFLPSFLPSFLPSFLPSFLPSCSASFLLVCIPPSFLSSFSSFILLSFLPFCLPPSLFPSFFPSFLHFSFITVIRVTSFPTSFLLTRLPSFLPSRFHSCNPFLLPVFLFAFRLLSFLSFFPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CFY7</accession>
    <name>A0A812CFY7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_34569</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001470">
        <property type="protein sequence ID" value="CAE1265209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CFY7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="322"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1265209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="376" mass="45148" checksum="E493371A0526426F" modified="2021-09-29" version="1">MTFDTVFLFQQSILAISTTIIIVCSLSLYFNVFLTSHISSFFSQPLCTYHVYPILCLSIFSLSLTLCLSSLCLLLLGYIFPSPFFYLNFLFHFFDVTLFICLLKRRLIKKRKKIFFISLSLNLYLLFCLYFFPYLYISAFIYLSVYLSIYLSIYLSIYLSIYLNLIYLSIYLSKSVHYLSIYLSIYVIILYLITYFSIYLSIYLSIYLGGEMFMIFLFSFFGFLFNFLSFCLFLIITFLLSFSSFYYFQSLLSFCLFSYFHFFLSFFLSFFLSFFLSFIYLFPILSFFFFKFPVYLSIYLLLFVHIYLSIYLSIYLSIYLSIYLMLFFKIYLSIYLSISIYLSIYHSDLLNIFKICLFLSIYLSIYLSIYLSIYRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CG48</accession>
    <name>A0A812CG48_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_34665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001477">
        <property type="protein sequence ID" value="CAE1265420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CG48"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="341"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="400"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="422"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1265420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="441" mass="52483" checksum="61FA0E70B7362DD6" modified="2021-09-29" version="1">MSRNVRHCLFIHSARKCQPFIFFYYTVAIFIRVAVPEMRFPCLSLISFVLSFFLSVHCLVLLLSFFLSFFLSFFPMFISFFLSFFFQCLVSLLSFFLSFFLSFFPLFSIASFFLSFFLSFFLSFFLSIHRLVIFFFHLPPSFFLFISFFLSFFLSFFLSLNWSTLSRESVSLREQTILLFVFFFFLSFFLSFFLSFFLSLHRPLALPVIKQSLRQNSTRWTALCLLFPSASPPTPPLHPVTFFLPPPDSKLLIRLLPFLSFPPPSFQCIFFHYSSHSISSYSSSTTNTTASFFLSFFLSFFLSHLFMRIDLFLFSSHLFSSFLFFFSFTSSSFFSFSSSSFFFFFSFLFFFSFTFFFTSSSFLFFFSFTFSSSFFSFSFLFFFSFTFSFSAFFSSSSYSFLFFFFFTFSSSSFFFFFSPSSFFLSSFLFFFSFIFFFFIPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CJT6</accession>
    <name>A0A812CJT6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_37278</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001661">
        <property type="protein sequence ID" value="CAE1271552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CJT6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134:SF22">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134">
        <property type="entry name" value="OS08G0543275 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1271552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="237" mass="27274" checksum="509E381B4B703BFC" modified="2021-09-29" version="1">MHTYTTTYLYLSIYLSIYLSIYLSLHIYIGIVLQGVTNLFSIYLSIYLSIYLSISVCSYLSIYLSIYLSLFVSLSVRIYLSIYLSISVRIYLSISVRIYLSIYLSIYLSQSVLIYLSIYLSIYLSISVCSYLSESVLIYLSIYLSIYLSIYLCSYLSISVRIYLSIYLSLFVSLSVRISLCSYLSIYLSIYLSIYHSIFFSLSPSLFLSRNVFSLPLPLSLSPFISILNSAFFNLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CMY2</accession>
    <name>A0A812CMY2_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_40190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001895">
        <property type="protein sequence ID" value="CAE1276681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CMY2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <dbReference type="EMBL" id="CAE1276681.1"/>
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            <dbReference type="Proteomes" id="UP000597762"/>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="5" xmlns="https://uniprot.org/uniprot">
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</entry>
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        </source>
    </evidence>
    <sequence length="409" mass="48913" checksum="59D12C90A1566864" modified="2021-09-29" version="1">MGEISLSLSLSLSLSLSPIYVSLNFLLSSIPIYIFFSIYSLSHLSIYLSIYLSIYLSICFSQFIIYAKCIYVFIYMYLFRIYFSLYLPLFISLLYRPFLSIYLSIYLSIYLSIYLSISALASICFHPPFFTRFFAPTIRFAFFVFLPRRYFSLSLSSFCACSLYVPFLSPFSFFLSLISFLFFLSFSSPSFFFYFIFFLLNLSCFFLSFFFLSFLSFLFSFLQSILHFSYFFQSIFFLSFILSFVFSFFLSFFLFFHTCGFSLFYQSSFISLRSLTFLFRLRMRTVTASSLDSILHITLFFLLRLHIYFFFIIILSHTNVSMFFYHPFLFAVHSFTFSSWLLRHFFSLHLLHYSIFFFLSPPFLFPPHFHSSFFLLTFCILKLSLYFLSFSLFPIYFHGYIYSLTIFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CTM6</accession>
    <name>A0A812CTM6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NapH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_39927</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001878">
        <property type="protein sequence ID" value="CAE1276294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CTM6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1276294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="173" mass="18127" checksum="057CA53A4AC81E5A" modified="2021-09-29" version="1">MRDMSISCRLYGVRNYYSHLGTRQKTQLQVTSSSSVLQLFSPRSELFSLPSEVISSLCLPGLNCSACLACNFTACLACNSSACLACSSSAYLACNSSACLACSSSAYLACNSSACLACSSSACLACSSSAYMACNSSPTSLRLSSNFLLFDLAATSLPVRAKTDRPFLPARGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CU11</accession>
    <name>A0A812CU11_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_41689</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002013">
        <property type="protein sequence ID" value="CAE1279254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CU11"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1279254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="296" mass="34817" checksum="2E7B625EF1FF8BB7" modified="2021-09-29" version="1">MSLFSPFTLLFLYSSLPSYFSFPLQFSYFTVLLTSLPLPLPSFTVAFLYASLLLHFSSFTLLFISTSLPLQFSSFTLLSIYSSLPLHFSYFILLFIWHLSSVHFSCFILHFLYTSLHLQFSPITLPFCYTSLLLHFSYFTHLLTYLPLQFSSFTLLLIYTSLILQLSSFTLIFLYSSRLPYFSFPFLFLYTSLPLQFSSFTLLFISTFLFYSSLPLPFSSFKIFFIYTSLSLQISPFTLLHYNSLRFHFSTSLPFYFTFLYTFLPLQFSSLQFSSVTLPFHYISLPLHYSSFKRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CVJ6</accession>
    <name>A0A812CVJ6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_42757</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002105">
        <property type="protein sequence ID" value="CAE1281224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CVJ6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1281224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="161" mass="18938" checksum="1EF570ACF083F704" modified="2021-09-29" version="1">MLLSFSIIWLLSTTAHLNPRTVFTIYSQHFLSIYLSIYLSIYLSIYLSIYLQQVSKNFSGFFLTQIFLSISKLLSLFCSIKIKHFLSFLFLSFFLPSFIPSFSFLLSFVLSFLPPLIHSFLTSFLSSFFLHLFLPSFLPFFIHSFIHSLLHFFLSSYFMFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CVN5</accession>
    <name>A0A812CVN5_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">SPHA_40759</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">Farmed</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">In the C-terminal section; belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="3"/>
    <dbReference type="EMBL" id="CAHIKZ030001935">
        <property type="protein sequence ID" value="CAE1277570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CVN5"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19773">
        <property type="entry name" value="Bbox2_TRIM23_C-IX_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19774">
        <property type="entry name" value="Bbox2_TRIM23_C-IX_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16645">
        <property type="entry name" value="mRING-HC-C3HC3D_TRIM23_C-IX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000130">
        <property type="entry name" value="E3 ubiquitin-protein ligase TRIM23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000486">
        <property type="entry name" value="E3 ubiquitin-protein ligase TRIM23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003649">
        <property type="entry name" value="Bbox_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00502">
        <property type="entry name" value="BBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="18" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="15">
        <location>
            <begin position="38"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="16">
        <location>
            <begin position="130"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="153"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="418"/>
            <end position="425"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="425"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="442"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="464"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="520"/>
            <end position="523"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00061142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CAE1277570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="581" mass="65750" checksum="63CBAEEFE06B620C" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CVT5</accession>
    <name>A0A812CVT5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_44626</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002280">
        <property type="protein sequence ID" value="CAE1284157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CVT5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="35"/>
            <end position="54"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="61"/>
            <end position="81"/>
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            <begin position="486"/>
            <end position="506"/>
        </location>
    </feature>
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        <location>
            <begin position="672"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="716"/>
            <end position="736"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAE1284157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="753" mass="87131" checksum="DF8C7E6786F73604" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CX18</accession>
    <name>A0A812CX18_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_42553</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
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            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
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            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002090">
        <property type="protein sequence ID" value="CAE1280809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CX18"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="81"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1280809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="178" mass="21040" checksum="E2D864E82F6C8434" modified="2021-09-29" version="1">MLFPDSYNVSCPSHLVEDYCFYAVASRSFEDSSAWGQRLPFDARNASRVFLVELLKPFLMPLAISQSKRITSDTEEMHYEFLFIIYLSIYHSLFISIYLSIYLSIYLSIYLSIYLSQSIHIYLSIYPNLSLLLIEYFIYIQYCTTRLKLILNIVQIYLSIYPSIYLSIYLSIYLSIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CZ97</accession>
    <name>A0A812CZ97_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase</fullName>
            <ecNumber evidence="3">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SPHA_46094</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Farmed</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Responsible for synthesis of pseudouridine from uracil.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a uridine in RNA = a pseudouridine in RNA</text>
            <dbReference type="Rhea" id="RHEA:48348"/>
            <dbReference type="Rhea" id="RHEA-COMP:12068"/>
            <dbReference type="Rhea" id="RHEA-COMP:12069"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pseudouridine synthase RluA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="3"/>
    <dbReference type="EMBL" id="CAHIKZ030002412">
        <property type="protein sequence ID" value="CAE1286516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CZ97"/>
    <dbReference type="OrthoDB" id="424794at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02557">
        <property type="entry name" value="PseudoU_synth_ScRIB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluA-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006225">
        <property type="entry name" value="PsdUridine_synth_RluC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050188">
        <property type="entry name" value="RluA_PseudoU_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00005">
        <property type="entry name" value="rluA_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600">
        <property type="entry name" value="MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600:SF40">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE RPUSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Pseudouridine synthase RsuA/RluA-like" evidence="5">
        <location>
            <begin position="137"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="363"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="365"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="391"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR606225-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAE1286516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="463" mass="53842" checksum="D13E66E0F0AE13B4" modified="2021-09-29" version="1">MLGFISTWKRQQKKGIEETGPLTTNPDPGYSSDVLSETEYYFEDGLRKVYPYFHTFTSYVKGRWLGRTVWDVFTKEFHVSTEENLLQDINSGLLRVNDKIVTADYKLKFNDLLSHRIHRHENPVIGTKLEIIEDNEHVIVINKPSSIPCHPCGRYRYNSIVFILGKEYGYTNLRNIYRLDRLTSGVLICAKTSEKTRELEDQILNKSVQKEYVCRVVGKFPDEVEVDQPLECINHKISLWQVRESGKPSKTLFKRLSYNGTTSVVQCFPLTGRTHQIRVHLQYLGHPIINDPLYSGDFWGPEAAKGKIFKCEIDEKKVGEEVIKNHNIGLWEKGPHPLFQTRLQQVKEEAARRKAAASTNLVNISHEEETKSTKDGDSHEEATEPPLKRFKTNDEDKMEESRPSFDLQKWIPNENCIHCKTEYIDPQPKDLIMYLHALSYKGPDWKYQTSLPDWAQPNWQEEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CZJ0</accession>
    <name>A0A812CZJ0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_43241</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002158">
        <property type="protein sequence ID" value="CAE1282109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CZJ0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008075">
        <property type="entry name" value="LIMR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01692">
        <property type="entry name" value="LIPOCALINIMR"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="73"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="189"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="195"/>
            <end position="217"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="224"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="278"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="309"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="354"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="384"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="414"/>
            <end position="434"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="440"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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    <feature type="transmembrane region" description="Helical" evidence="1">
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="530"/>
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        <location>
            <begin position="910"/>
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        <location>
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            <begin position="966"/>
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        </location>
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        <location>
            <begin position="1033"/>
            <end position="1058"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1282109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1065" mass="131928" checksum="5B3A9088FF77CA27" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D052</accession>
    <name>A0A812D052_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MKLN1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_47736</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002613">
        <property type="protein sequence ID" value="CAE1289605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D052"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
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        <location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="131"/>
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        </location>
    </feature>
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            <begin position="459"/>
            <end position="481"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1289605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="484" mass="58987" checksum="9E5B21D44AD2C2DC" modified="2021-09-29" version="1">MHSLLCSPLSSHLSLSLSLFLSFSFPLSLCLVRCKKKSTSDISDSSTFFSPSLSSRLYFILLCFFEIFYKGSDQLISWGPTLNFTIFHPPTPQLHDLCVSQICYSRQPVVSLPRFLMSMVTSFSPNFRNDLPLPSLLSLSLSTLSLIILFFSFPSLFPFSYFLYQLFLLLLFFSVFFSLFVLFFLCVFSLFLFFSFCSIFFVFFFLFRLCLLFSFSSLSSFFLFRLCLLFFFFVFVFFFSLSSLSSFFSFSSLSSFFFFVFVFFFLFRLCLFLSSFFFFFVFVFFFFFFVFVFFFVFVFFFFFFVFVFFFSFFVFVFFFFFFVFVFFFFFFVFVFFFFFFVFVFFFFFFVFVFFFFFFVFVVFFLCVFLFLFFLFVLFSLSSFFFVVFVFFFSLSSLSSFFSLSSLSFFFSLSSLSFFFFFFVVFVFFFCRLLFFLFRLCLLFFLFRLCLLFFLFRHFFVFLCFSLSFLLLLFFFFHFFLFPHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D0R2</accession>
    <name>A0A812D0R2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_43907</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
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            <taxon>Coleoidea</taxon>
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            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002224">
        <property type="protein sequence ID" value="CAE1283124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D0R2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1283124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="155" mass="17547" checksum="DFE845153786534D" modified="2021-09-29" version="1">MTNIISLSLSFFLSHAGYRRERRRRGEREALPYLGYCVSHKQERIRFQQQPGPSPPYTDHNFSPFWNNLGPLPTIHASPFFFLHRHVEVQLRLSHRLRLLVSPAAAAAAASDAAVVAWQLLFPGHPDGEAELPTWLPSSPPQSTRCRPSLVLSPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D575</accession>
    <name>A0A812D575_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_47539</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002578">
        <property type="protein sequence ID" value="CAE1289188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D575"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="266"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1289188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="294" mass="34478" checksum="46E547E5292FF073" modified="2021-09-29" version="1">MFQSCRRITHRTLFQNGHDLMHFTAVQINFSSSSSSSSSSSSSSSPPPSSFDHFFLIPYCFCIFLKLSFFLSFFLSNDRPLPFLDISIPPFFLSFFLSFFLSFFCLSVLFFLSIFQSAYLSIFFFLSVSFFYLSIYLSIYLSIYLSKLSYLSIYLSIYLAKPVHYLSIYLSKLIYFLHLNLSKPVHYLSIYLSIYLSIYLSIYLSIYVYLLSIPLSNPVHYLSIYLSIYLSIYLSIYLSKLIYFLPQNLSKPVHYLSIYLSKLSYLSIYLSIYLSIYLSFLIYLSIYLSIYLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D6L1</accession>
    <name>A0A812D6L1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_47054</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002524">
        <property type="protein sequence ID" value="CAE1288309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D6L1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="131"/>
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            <end position="247"/>
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    </feature>
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            <end position="345"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="375"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="412"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="424"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="492"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="522"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1288309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="542" mass="64946" checksum="8A44265FB627D1ED" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D7G8</accession>
    <name>A0A812D7G8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_48061</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002655">
        <property type="protein sequence ID" value="CAE1290077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D7G8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
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        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
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            <end position="378"/>
        </location>
    </feature>
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        <location>
            <begin position="384"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="471"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1290077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="498" mass="58725" checksum="82B5CF5BA3D85B73" modified="2021-09-29" version="1">MIYLFIYLSIYLSIYLSHSVHFYLCIYLSLSQFISIYLSIYLSSYLSNSYLSIYLSIYLSLFDIYLSRCISIYLSIYLSIYLSHSVHIYLSIYLSHSVHFYLTLFISIYVSISKSESVNIYLSIYLSLSQFISIYLSSIYPSIHLSITLCSYLSIYLSIHSSIHLSIYLSHSVHIYLSILSIYPSIHLSITLCSLLSHHFISIYLSIYLSIYYTLFIFIYPSIYLSIYLSHSVHIYLSIYLSIYLSIYLSHSVHIYLSIYLSIYLSIYLSHSVHFYLTMFISIYVSIYLNAESVHSSIYLSYPSSIYHTLFISIHLSIYLSIYHTLFIHLSIYLFIITLVHIYLFIHLSITLCSYLSIYLSIYSSHLSYSFIYLSIYLSKSESVHIISIYLSIYLSTFDIYLSRCIFIHLSMHLSIHLSIIYLSRSLHYLSIYLSIYLSIYLSIYLGLSLFIIYHSFIYLSIYLSIYLRSLHYLSIYLSIYLSIYLYMYACVRVCMDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DAQ8</accession>
    <name>A0A812DAQ8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_52493</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003271">
        <property type="protein sequence ID" value="CAE1298245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DAQ8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="121"/>
            <end position="145"/>
        </location>
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            <end position="180"/>
        </location>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="361"/>
        </location>
    </feature>
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        <location>
            <begin position="368"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="396"/>
            <end position="429"/>
        </location>
    </feature>
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        <location>
            <begin position="436"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="480"/>
            <end position="501"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="521"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="548"/>
            <end position="567"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAE1298245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="571" mass="68669" checksum="6A01638F026A01B9" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DBJ8</accession>
    <name>A0A812DBJ8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_51046</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003062">
        <property type="protein sequence ID" value="CAE1295708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DBJ8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <begin position="20"/>
            <end position="43"/>
        </location>
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        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1295708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="268" mass="30376" checksum="9652FE2A9B8D6691" modified="2021-09-29" version="1">MGQPFIILIFHGTEENKTILFSLLHIFLLSFSFSSFSILSHALSLSLSLSLSHLYVREGGDISFAVFHLPSPFYPSYFLPFNSLLLFLLFPSLPFIPPIFPLQLSPFIPPLPSPFYSSYFSPFIPLPPHFIPHFLPFNSLLLPLLFLLLYLSLLFLLFPPFYPSYFPSFNSLLLSLFPSLPSPFYSSYFLPFTSPFYPSWFLPFLLPFIPSISSSSFSLVSLLFPSISSSPVISLSLPSIATKSLLFLPLLLFSHISFFFSLMPVSFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DCM4</accession>
    <name>A0A812DCM4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_52894</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003326">
        <property type="protein sequence ID" value="CAE1298884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DCM4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1298884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="230" mass="27087" checksum="647BF7BFED01C6F4" modified="2021-09-29" version="1">MRHKNAYLRHKNERLLATPKTNAFLRMNTLQQQTSKTAPKTAAEGRLTATAFFEKSLFLSFFLSFFFSFSQGYIFCLLLFASGVRSFFPILSSLSPFLFFSLFHSLSLSFYLSFFLYLFLPLFLSLIFSLSLNVSGLSFTFLYLTFSLSLSLTFILLFFLSFILLFFLSFFLSFSFSFFLSFFLSFSFSLSRLLFLFTFICFCFICSVYQFLLKYLSNMMIFEEETFRQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DCQ3</accession>
    <name>A0A812DCQ3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_53902</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003443">
        <property type="protein sequence ID" value="CAE1300393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DCQ3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="360"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1300393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="395" mass="48229" checksum="15FD36F2B24614C9" modified="2021-09-29" version="1">MYLLFLCQILFIYFIFFPLAFLFFLYFLLSFSSFLSFFLYFPLSLFPSFFLSFSFFLSLFLSFLSFSFFISLFLYFLLSFFLFLSFFPYFFISFFLSFSFFLSLFLSFLLSFFLSFLKSLFPSFFLSFFLSFSFFFFLSFFFISFFLSFFLSFFLSLNLYFLLSFFLSFFFFLFLSFLFLYFLLSFFLFLSFSFFFFLSFFFISFFLSFVFFLFLSFSFFIYFLSSFFISFFLSFLCLSFFPFYFSSFLIFLFPSFFLSFFLSFFPFFFLSFFPFFIISFLLSFLFLFFFPCFFLSFFLSFFLSFVFFDIFHFRTFSLPSFAPTFFMLSLSLSLSLSLSLSLSLPTCMPVSFSCKTREIFPVLILAFFLSFFLPFFLSFFLSFFLSSFLSFFLSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DD69</accession>
    <name>A0A812DD69_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">GSK3B</fullName>
            <ecNumber evidence="10">2.7.11.26</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SPHA_50759</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Farmed</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.26" evidence="10"/>
    <dbReference type="EMBL" id="CAHIKZ030003013">
        <property type="protein sequence ID" value="CAE1295137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DD69"/>
    <dbReference type="OrthoDB" id="272141at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050321">
        <property type="term" value="F:tau-protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090090">
        <property type="term" value="P:negative regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032436">
        <property type="term" value="P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070507">
        <property type="term" value="P:regulation of microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14137">
        <property type="entry name" value="STKc_GSK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000009">
        <property type="entry name" value="Glycogen synthase kinase-3 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000082">
        <property type="entry name" value="Shaggy-related protein kinase kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050591">
        <property type="entry name" value="GSK-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039192">
        <property type="entry name" value="STKc_GSK3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24057">
        <property type="entry name" value="GLYCOGEN SYNTHASE KINASE-3 ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24057:SF0">
        <property type="entry name" value="PROTEIN KINASE SHAGGY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="36"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAE1295137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="305" mass="34917" checksum="4DD31D62E81F1B27" modified="2021-09-29" version="1">MPHPLSKDLLYKDGSKVTTVLATPGQGPDRPQEIGYADTKVIGNGSFGVVYQAKLIDTGELVAIKKVLQDKRFKNRELQIMRKLEHQNIVKLKYFFYSSGEKKDEVFLNLVLEYVPETVYRVARHYCKSKQTIPTLYIKLYMYQLFRSLAYIHSQGVCHRDIKPQNLLLDPETGILKLCDFGSAKVLVRGEPNVSYICSRYYRAPELIFGATDYTCQIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKPHPWPKIILNMVLPYNFVSVGQILHHHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DEJ3</accession>
    <name>A0A812DEJ3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_52608</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003302">
        <property type="protein sequence ID" value="CAE1298523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DEJ3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1298523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="180" mass="20401" checksum="840B5F6A2074C719" modified="2021-09-29" version="1">MELELQSECRLQDSNLGSIRSIAVSDEDGHVFVVDEGDNSIKEFGETGEFVGQCFLAFERFSPLDICCLSQDNFVTLLLPFLNFIPPSLYLKLFFSLHFLYTLLHPRLFTSLYIAYVFQKKGKNPPPFHSHSLSLFLSFIKLFLLSFIPPSSPSLNAAILSLLCYRRKSLQSSGVIILVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DEZ1</accession>
    <name>A0A812DEZ1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_54558</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003547">
        <property type="protein sequence ID" value="CAE1301690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DEZ1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1301690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="200" mass="22853" checksum="A870F9FF8373A983" modified="2021-09-29" version="1">MLDFLSSSGPLYFFCPFLVHPYSLSFGFLSSLWSFCVLFLFMLAFLFFPLVLLSFSIHAGFSLFPLILLCSFSIHAGFSLSVPSRPSVSFSIHAGFFSLIPLVSLFFFFMLDFLSFLFCPFLFMLPFPLLWSFCPFFMDFLSLSCFSCWFSLPSGPSVSFSIHAGFSLFFSLSWSFCVLFMLVFSSLWSLCPFLFFLSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DH33</accession>
    <name>A0A812DH33_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">TMED5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SPHA_52090</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003211">
        <property type="protein sequence ID" value="CAE1297602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DH33"/>
    <dbReference type="OrthoDB" id="5976732at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.680">
        <property type="entry name" value="GOLD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="GOLD" evidence="9">
        <location>
            <begin position="17"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAE1297602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="180" mass="21071" checksum="85641FEF1C4E3F9F" modified="2021-09-29" version="1">MKRQAVERGGGKITNSQHTIPFVVQITKTGETTLEVEYQVIDGGDMDVSFYIQAPSGSILVAEDKKSDSAHKVDIQLTGTYKICFDNTFSRFFRKVVYFDIITENEDDEIDNRNWTFSKDDAAELMEIKLEDFKSIVERVKENLERSHQVQNYLKMFEARDRNIQESNFERIMNNYRLHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DKU8</accession>
    <name>A0A812DKU8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_57864</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003920">
        <property type="protein sequence ID" value="CAE1305430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DKU8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="273"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="302"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="337"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="366"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="398"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="444"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1305430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="465" mass="53052" checksum="EBE6F1F7AAC00B26" modified="2021-09-29" version="1">MFVSLCLILFISIDIYHSLSFSSSIFQSHFVHVYQSLSFSFILYLTLSISFCSCLSISLILFHSLPHSFYLILFMSVSLSLFSFILYLTLSISFCSCLSVSHFLFHSLPPLSISFCSCLSVSHFLFHSLPPLFYLILFMSVSLSLSLSFSTSSFYLILFMSVSLSLFFHSLPHSFYLILFMSVSLSLSLSFSTSLFLSHFVHVCQSLTFSFILYLTLSISFCSCLSVSHFLFHSLPHSFYLILFMSVSLSLSLSFSTSLFLSHFVHVCQSLTFSFILFLNLSISFCSCLSISLILFHSLPHSFYLILFMSVSLSLSLSFSTSVFLSHFVHVCQSLTFSFILFLTLSISFCSCLSVSHFLFHSLPHSFYLILFMSVSLSLFHSLPHSFYLVLSISIDFSFILFQTLSISFCSYLSISLFICHSFFQSFYHILLISIDLSLYLSLFYFLCHSFYLILLISISLSFCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DLF2</accession>
    <name>A0A812DLF2_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">V-type proton ATPase subunit C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SPHA_57134</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Farmed</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and two accessory subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the V-ATPase C subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003839">
        <property type="protein sequence ID" value="CAE1304570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DLF2"/>
    <dbReference type="OrthoDB" id="6605928at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14785">
        <property type="entry name" value="V-ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000002">
        <property type="entry name" value="V-type proton ATPase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1460.10">
        <property type="entry name" value="subunit c (vma5p) of the yeast v-atpase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1180">
        <property type="entry name" value="Vacuolar atp synthase subunit c, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004907">
        <property type="entry name" value="ATPase_V1-cplx_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036132">
        <property type="entry name" value="Vac_ATP_synth_c_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10137">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10137:SF0">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03223">
        <property type="entry name" value="V-ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118203">
        <property type="entry name" value="Vacuolar ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAE1304570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="483" mass="55657" checksum="0DB071C0849FA024" modified="2021-09-29" version="1">MQSLTFTPSLFLFMSSSYFKFLSCFFFSAFSSLNFLSFPLLSSPLTIILPLFLTIFFLSFTFICKINRNKLFKLFFLKKRFIGSEIALSKQNNLSTNYKFQIPDLKVGTLDVLVGLSDDLGKLDDYVERVTRKIAHYLGEVLEDHKDNLRENLKAGGVDLVTYLFRFQWDLAKYPIKQSLRNIAEVISKQVTQVETDLKTKSSSYNSLKGNLQNLERKAAGSLLTRNLADIVKKNDFVLDSEYLTTLLVVIPKNHANEWKAKYETLTDMVVPRSSRILYDDPEGDSVLWSVTLFKRVVDEFKHHCREHKFSVRDFTYNEEELIAGKNELSKLEADKKKQFGPLVKWLKINFGECFAAWIHVKALRVFVESVLRYGLPVNFQAILLHPHKKSTRRLRELLNQHYSHLDSAALAGGTDHGMDIPGLNMGTTEYYPYVYYKINLDMLDSTKDHLSRWTCGYLSIFRASSPSISPLFIFKSNNSLSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DS80</accession>
    <name>A0A812DS80_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mitochondrial import inner membrane translocase subunit TIM50</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SPHA_59390</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Farmed</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the TIM23 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the TIM50 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004111">
        <property type="protein sequence ID" value="CAE1307267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DS80"/>
    <dbReference type="OrthoDB" id="287041at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000019">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit TIM50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9 12" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="FCP1 homology" evidence="14">
        <location>
            <begin position="116"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAE1307267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="323" mass="37564" checksum="093F9D7F3648F8B3" modified="2021-09-29" version="1">MKEAVPASTTPVKDGQSDQSSGDKKEKDSKWSGRNAWKYGLLLLGGWATVTTGVLINIWGAPAIDPEGNEIKDEFSDMSFLQAYLKRALKEFHQYKQMLKDPSRDKLLPDPLQYPYMQPPYTLVMEMTGVLVHPDWTYGTGWRFKKRPGLDYFLQQVGPPLFEIVIYTSEQGYNADPILNNLDPNGYVMYRLYRDATRYVEGHHVKDLSCLNRDLSKVIIIDWNKASTKLQEENRFLLKRWTGADDDRTLIDLANFLRTLSMSGIEDVRTVLQYYSEFEDPIGAFRENQRLLQEEQEKQVRLLEEKEKKKKSTPWMPSLFSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DVH3</accession>
    <name>A0A812DVH3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SPHA_60558</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004214">
        <property type="protein sequence ID" value="CAE1308736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DVH3"/>
    <dbReference type="OrthoDB" id="5970161at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716:SF4">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 245"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAE1308736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="221" mass="24898" checksum="96DF64EADC0BA739" modified="2021-09-29" version="1">MPLPHQPPQLQQPPQSQQRHQQPGKKMASPSFEYFRSSFDNVFQILPQGHEKALKKALYNTAANFFVIFASLVVVAGYFVLQAFLRPLLWAVLCGTFLYPFKRTLTSGLRSWLQGLDQSGTPFAAGLVLLPLKSVHDVSEMTLFFLGFILSSFFSTRHLITLIQFGSFLLFSLFLPLLPFLPPFLPPPHFLASLFAPSSLSCLPFCPLPFLSFNFCSLCIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DVN3</accession>
    <name>A0A812DVN3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_60683</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004230">
        <property type="protein sequence ID" value="CAE1308862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DVN3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1308862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="187" mass="21904" checksum="9A691E9FB4924D40" modified="2021-09-29" version="1">MKPSSLLYTLLTGPSLFYFSGDFLLFLRGPSLLYFSGDFLLFLRGPSLLYFSGDFLLFLRGPSLLYFSGDFLLFLRGPSLLYFSGDFLLFLRDPSLLYFSEILLYSISPVTFYFFSEILLYSISPVTFYFFSEVLLYSISPVTFYFFSEVLLYSISPVTFYFFSEVLLYYISPVTFSQRSFFTIFLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DWU0</accession>
    <name>A0A812DWU0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_61952</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004394">
        <property type="protein sequence ID" value="CAE1310373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DWU0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033065639" evidence="2">
        <location>
            <begin position="22"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1310373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="271" mass="31879" checksum="AD00F41B8A904264" modified="2021-09-29" version="1">MRHLSFFLSFFFFFLLCPSLSYYDLSHNSFLLLIFCTPFSPPFFFFFLSFFFFLFFFFFFFFFSFLFFCFFFFLFLLVCVAFFLLFPFSVSVVFSHSLYRCFSPLHSVWRCFLSPLHSVFFFFFSPPPFSVSVVFSPPPFSVALFFSPLHSVWRCFLSPPFSVMFFSLPSPPFSVRCFSPLPSKKCDVVFLSPPLHSVWRFFFSPPLHSVWRCFFLPSPSILKRLFFFPLPSIHVALFSPPPLHSVCGVVFSPFPPFSVALFSLPLPLHSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DXU5</accession>
    <name>A0A812DXU5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_62514</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004476">
        <property type="protein sequence ID" value="CAE1311051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DXU5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1311051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="217" mass="27024" checksum="8473A96DE94219CF" modified="2021-09-29" version="1">MFYHFFLFVFSFFFHFLFRFFFSFVFSFFHICLFRFHCFLGFSYSYLFSRFFFHLVFSRSFSRFPHLPFTFFSCYFSHFFFSYFAFSFIFLNFFFLVFSFYDHYCFLFRTDFTVFSLPFPFFALSFSIFSYFLVLPPSIFPFPVFFHFFLICFFSLIFLVFICLSVFFSLHFRLFSRFSMFFFLIFLSDILVFFSFIFPFIQVCFSVFLNDVPESLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DXV4</accession>
    <name>A0A812DXV4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_62570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004482">
        <property type="protein sequence ID" value="CAE1311075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DXV4"/>
    <dbReference type="OrthoDB" id="10624990at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1311075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="317" mass="36451" checksum="9AB249C7A54139B5" modified="2021-09-29" version="1">MPPPLSSSSFSSSSSFFFFYICTYININLSIYLSIYLSIYLSIYLSKGCLLSSPPQSDHIYLSIYLILFHIYLSIYLSIYLSIYLSYSVSHLSIYLSILFCFTSIYLSIYLILFHIYLSILFCFTSIYLSYSVSHLSIYLSIYLSIYLFHIYLSIYLLFLSIYLSYSIYLSIYLSIFYLIHITSIYLILIAVRFIASSFLYIIDIRYNASLVINGIVIRYNVSSVICSIVTRYNASSVINGIVIRYNASSVIYSIVICYNASSVINRIVTRYNASSVICSIVIRYSPSSVIYSIVIRYIVSSILYIIVFPYNVSSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DXW3</accession>
    <name>A0A812DXW3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_62564</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004482">
        <property type="protein sequence ID" value="CAE1311089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DXW3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="13"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1311089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="298" mass="34514" checksum="1B9D6E231357580C" modified="2021-09-29" version="1">MLHRPMRQHRRKISIYLSIYLSIYLSIYLSAYILFSTTSLHSLAFLNPLPNSLLFLNQTSFLSFLVLKPISRDLSLPNAKLFFYFSPLKVIRHYLLKPNHFFFHFSRKTYFSIPTASLISISLLLKPPHFSSKIQTHFLQFSSSSLPKANIISFTPLKPTSLLFRNPTTLFPLFFRKPYLSVLNANLISVTPLLKPTSLLFLIRNTLFPHFFQKPSLSLLKANLISISLLLKSPSLLFLNTISLFSPIFVNTSYFFIFQPNYLALAFCNHLHLSIYLSIYLSIYLSIYLSIYVNSFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DZ97</accession>
    <name>A0A812DZ97_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_63442</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004545">
        <property type="protein sequence ID" value="CAE1312113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DZ97"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1312113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="259" mass="30934" checksum="DC174890915DDDF6" modified="2021-09-29" version="1">MFFSFFLSCPFKLISFFILYFIRCATFHFIFTFSNFFVLISSFVSFFPLQFIFLSKIRSFPFRFIRLFVFLLLFMKNNLIIQSFFPFLPSFFLHSFLPFQDTLSSFSLLLSIYLSIYLSIYLSIYLVLFMIYLSIYLSNSIHDLSIYLSIYLSLSFIYLSIYLSIYLSIYLSIYLSIYLSSPVHDLSIYLSIYLSIYLSNCILIIYLSIYLSIYLSIYLSIDRVCVYMSPTHLIILNVMCHFIQCAFFLFVNYNTLYLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DZG1</accession>
    <name>A0A812DZG1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_61461</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004353">
        <property type="protein sequence ID" value="CAE1309817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DZG1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1309817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="284" mass="33174" checksum="98B387187EBE99E6" modified="2021-09-29" version="1">MIFDSSECFLSCHLAHYIFDASFFGYYFIFNITTVLPFSRTFLSTLPHLFLIQCVFYDFTFSIFSDFVHLFHSFIYFLFIWLSFSYFISLDPFPSLNSNFSFTLTNYLSLADLSFPSVHLATAFTFQSLSSYYPLPLLFVLFSFSLKPFSAPFPFSLSVLFISFLHYYIIRFFNSISIYYFLAFHHLESDNILYIICHKIRIYLSIYLSIYLSIYLSIYLSITITIFTVTAASPDYLSKSIMRITLNGVATDVLTPAVLTPHLHFPFFHLVFVPLPFSPLSMYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E2F4</accession>
    <name>A0A812E2F4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_66623</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004810">
        <property type="protein sequence ID" value="CAE1315750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E2F4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1315750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="187" mass="23569" checksum="DA2E60847DAD64BA" modified="2021-09-29" version="1">MVCVTGSCRFLLRFFPLVSFHIRAIHNLLDTYHFFYFKLPNYSHFLFFFFLIFSFFLRFFYFLFFSIFLSVTFFITFFLSFSLFLLSLLLSFFLCLFYFFFLSFFLSFFFLSFFLSFYISRFFFFLFPFPFYISFLSFFLSFFFLSFFLFVSLFFLFSFLFLFFLSFLSFFSFFFFFLFFVLFYFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E467</accession>
    <name>A0A812E467_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_67996</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004932">
        <property type="protein sequence ID" value="CAE1317448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E467"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1317448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="218" mass="24826" checksum="4E4BE242F9A6E68A" modified="2021-09-29" version="1">MTIRFYLNSPVVISLLQSLSLSLSLSLSFGISPNPSPQNNPPPLRSSCQTIFFPCLFPFCSLIKLFSFSSSRTSQFLFITYSLPLSPPPLHLHVYHISSCIHFFPLTHTHLHPFSSQIIFSDTYTLSLYPTKSPSNYGFSHYIKLFSHLTTPFFPLISLGFFYPCLFLYFHHSLGHISFFFLKIIHVIYHNTSLSKPFPKGASFISPKHTKIIAPTNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E576</accession>
    <name>A0A812E576_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytokine receptor-like factor 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_66560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004804">
        <property type="protein sequence ID" value="CAE1315640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E576"/>
    <dbReference type="OrthoDB" id="9984427at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1315640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="456" mass="50808" checksum="93D1E488D29E7BFE" modified="2021-09-29" version="1">MQRSMPSVSTMTQELEQGVIEILDFAKEQKKELLGLLDALYEAKDQITSSGTRSREQLTSYFESLKSELILALDNRLAELAKQVDVIEQTSLPPLNECEGLINQGIYKVNRIIKEGSLILENNSADVEKVTNFKESSDSWNLNSVPAIPSLSEVACISVDRTGSCKEKLLDYISKECRVVGKAPVYIADVIERPGALLVKWSETEDDVDASEFCLQYASGTIKSNEDKHAPFHNAYIGGNSICLVKHLQTNHPYSFRASCRSDPDSAWSIWSVPTIACTTLPHYEWSAENSAYSTSNENQTATKCCGGEAVVLYSKSYLYTAGQSITFRVLDAGSTCPGDGVGLSLMNSDSHTLRRPGAAYVTVDGKVYVDGQEMKTKLPFWGKGSSVTFDTEVQPNGKVRVTVQVEEKEVTFDWNLPFIEKYMKDFTNEQNHSRPKEKFYFAMVFANEEWKVGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E6Z5</accession>
    <name>A0A812E6Z5_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SPHA_67611</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004896">
        <property type="protein sequence ID" value="CAE1316874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E6Z5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="252"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="79"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAE1316874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="280" mass="33196" checksum="F98FEF2D56250ACE" modified="2021-09-29" version="1">MLKTFSCFFIVFYSYLSIYLSIYLSIYLSMNIHCCLMPVHLRVQLEKKMNEKCSITLPGNCLRRVYFQCIFLWMKIYLSIYLSIYLSIYLIFLSIYLIVSIYLSHLSIYLSIYLSIYLSHSVYIYPILFMSEPVYFFHFLSLYVYLYILYSHLSIYLSIYLSIYLSIYLSQSVYILVCFFVSEPVYFSLSSLSLSLSPSLSLSLYIYIMAISLSLYLSIYLSIYLSIYLSIYLSMPNLCIYLSIYLSIYLSIYLSILICLYLFTLSILICLYLSIYLSIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E7T4</accession>
    <name>A0A812E7T4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_65990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004749">
        <property type="protein sequence ID" value="CAE1315040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E7T4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134:SF22">
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        <source>
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        </source>
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        <source>
            <dbReference type="EMBL" id="CAE1315040.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
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    <sequence length="857" mass="100236" checksum="A30F0C9B0BD9D63F" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EA39</accession>
    <name>A0A812EA39_ACAPH</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <source>
            <dbReference type="EMBL" id="CAE1320327.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ECP4</accession>
    <name>A0A812ECP4_ACAPH</name>
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        <submittedName>
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        </submittedName>
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                <person name="Bekaert M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        </location>
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        </source>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
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        <source>
            <dbReference type="EMBL" id="CAE1320373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="239" mass="28387" checksum="B71B88D64FD53BBC" modified="2021-09-29" version="1">MKCDFLSFFLLFLPISVWSYSTCTGTRTYTLSLSLSLSLSLSLSLSLSHTHSLSPYIHYRPKSVHIYLSIYLSIYLSISVFLSIYLSIYLSIYLSIHPSIYLSQSFFLFIYLSISIYLSIYIFFYLFIYLSIYIYISISVFLFIYLSIYIYIYIYLSLFIYLSIYLSISVFLFIYLSIYLSIYLSIYLSQSFYLSIYLSIYLSIYLSIRLLAELIIKVRTLNHLYNLHLFQNLLNHSWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
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    <name>A0A812EDS3_ACAPH</name>
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        <submittedName>
            <fullName evidence="7">ZMYND11</fullName>
        </submittedName>
    </protein>
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        <name evidence="7" type="ORF">SPHA_73315</name>
    </gene>
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        <name type="scientific">Acanthosepion pharaonis</name>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
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                <person name="Bekaert M."/>
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        </citation>
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            <strain evidence="7">Farmed</strain>
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        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005372">
        <property type="protein sequence ID" value="CAE1323445.1"/>
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        <property type="term" value="C:nucleus"/>
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        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:regulation of signal transduction"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:regulation of transcription elongation by RNA polymerase II"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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            <begin position="27"/>
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        </location>
    </feature>
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            <end position="195"/>
        </location>
    </feature>
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        <location>
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    </feature>
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            <begin position="354"/>
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    </feature>
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        <location>
            <begin position="204"/>
            <end position="260"/>
        </location>
    </feature>
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        <location>
            <begin position="282"/>
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        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAE1323445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="484" mass="56944" checksum="D00D7E757F8827CC" modified="2021-09-29" version="1">MTSHAGRKRNRIKGKMLNTLLGYTVQRLKEKTRELHKIGHRDEELSFKRFVYRPMDLNTMEQYVQHQKYRCVEELVADAHNIVHNVFLMYGEEHGMTELATIMIKDCKYDIDEIRQCWNCYFMSNSKPSNWFCRPCNPPHKLVYAKLKGFSYWPAKVIRISEDEKYDSVTLKRTRGFIKACEELKIHRQFLEEQDDMSSNGAESEVENNSEEEEAEEGEEEEEAAEGEEEEEEEEEEEEEEEEEEEEDDDEEEEEEDDIETREVTSTSVVPPKHISKLKTKVSNPENVNVVSSSVDKISSPSPMSKVMCKHTACQAFPTLSNKSTQTDTNSTKDCRCEEKFSSMFSEFEEKMENDHKKARDQELKELAERLQKDFEDDKQQAVARALSNMQREIERVRRQTTERSKEQCMDEMKKLAQKHKENISYIKKKQWCFYCEEEAIETLNGRKESLIRKQEFVPAHSPPSPQKQTKLAKSYVFSPKFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EIW6</accession>
    <name>A0A812EIW6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="18">CACNA1D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">SPHA_73127</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005368">
        <property type="protein sequence ID" value="CAE1323310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EIW6"/>
    <dbReference type="OrthoDB" id="431720at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008331">
        <property type="term" value="F:high voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000448">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000007">
        <property type="entry name" value="Voltage-dependent L-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000021">
        <property type="entry name" value="Voltage-dependent L-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000006">
        <property type="entry name" value="Voltage-dependent L-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050599">
        <property type="entry name" value="VDCC_alpha-1_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002077">
        <property type="entry name" value="VDCCAlpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628:SF1">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00167">
        <property type="entry name" value="CACHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12 14" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 14" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="3 14" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="7 14" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="414"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="611"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="642"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="726"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="809"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="846"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="880"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="909"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="941"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="975"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="999"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="17">
        <location>
            <begin position="18"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="17">
        <location>
            <begin position="270"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="17">
        <location>
            <begin position="609"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="226"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="454"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="226"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="242"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="477"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="503"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="527"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="539"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="395"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="823"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="13">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR602077-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602077-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CAE1323310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1022" mass="116509" checksum="D0AE218C48B0EE9C" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EKR6</accession>
    <name>A0A812EKR6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_74893</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005442">
        <property type="protein sequence ID" value="CAE1325273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EKR6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1325273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="313" mass="36975" checksum="D12196E63B670A48" modified="2021-09-29" version="1">MLLTLFLSESLADISPSSVISSFFLSFFLSFFLSYNTYTLSLFLFSLFLFLSFFLSYISKFFLSIYLIFLSFFLSFFLSIFPIFSFFQSFFLSNFFLPIFLSFFLSVFLSFFLSFFLQCCFFFIPSIHHHSSIYLSIYLSIIYLSIILISIYHCLFIYLSIYLSIYLSHLSIYLYLICHIHSIYLSICLFRSIYLSIYLSIYLSIYLDLSIYLSIYLSIIYLSIYLDLCIYHLSIYLSIYQIDHLSITVCSSSSVIHLSIYLSLSILICAYLSIIYLSIYLILHTDEYVFTYFIYFIYLSISLSLSLSLSPDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ELQ2</accession>
    <name>A0A812ELQ2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_78331</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005535">
        <property type="protein sequence ID" value="CAE1328706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ELQ2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1328706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="357" mass="41443" checksum="D74F04F2E6B6908D" modified="2021-09-29" version="1">MSVFTYLHVFFCNCLSFAIYPLLYHFLSLPLFVSLYLFLSLSLFISFYLFLSLYFFASLYFFLSLCLFVSLYFFLSLSLFVSLYLFLSLPPFVSLYLFPSLSLFILFYLFLSLYFFVSLYFFLSLYPSLYVDLFDSSPYFMFLFFSLTITLCFSSFCSLLLFVCLSLFQSLSFCQDKERIVRIGSLFSLSLSLSLSLSLSLYASLLVSLIFSIYLSVRFSLHVCLSFTLYSVPLSLSIPRCMCVSLFRSLSPFVYLSLFHSLPLILSFSISLSMPFFLSFYVPLCMSVSLFYLFCISRSLSFFFLYTCLSFTLCMSLFHSLYVSLSLSVRLSFTLCTSHFHSLFLFVRLPDIKGSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EMY4</accession>
    <name>A0A812EMY4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CAMTA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SPHA_77744</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005521">
        <property type="protein sequence ID" value="CAE1328134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EMY4"/>
    <dbReference type="OrthoDB" id="407555at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005559">
        <property type="entry name" value="CG-1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23335">
        <property type="entry name" value="CALMODULIN-BINDING TRANSCRIPTION ACTIVATOR CAMTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23335:SF1">
        <property type="entry name" value="CALMODULIN-BINDING TRANSCRIPTION ACTIVATOR, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03859">
        <property type="entry name" value="CG-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01076">
        <property type="entry name" value="CG-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51437">
        <property type="entry name" value="CG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="CG-1" evidence="4">
        <location>
            <begin position="13"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAE1328134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="252" mass="29668" checksum="DF8E40E7B32696A5" modified="2021-09-29" version="1">MIILPKQLEDIPIASEFPSVRHRWNTNEEIASILIAFDKHKEWQLRELRVRPPSGSMLLYSRNKVRYRKDGYCWKKRKDGKTIREDHMKLKVQGLECIYGSYVHSAILPTFHRRCYWLLQNPDIVLVHYLNVPYPDSAKLSIPVLSYGFEKKEWTKDELADQLRPMFSTGRPGEGIQDSEHVVSRNGCATYTIILSPIPLLICGSKAECFFLNQFTDNRLFDVQRLTIAAACSKDIWHENNLFFFFFFFFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EN34</accession>
    <name>A0A812EN34_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_75607</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005465">
        <property type="protein sequence ID" value="CAE1326037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EN34"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1326037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="392" mass="45692" checksum="05C6A923BA750C04" modified="2021-09-29" version="1">MTFHGRHGKKSTTDALQFLLNFLLYFYFFFFSFLFLFFFLYSFIESGNSHEHVTGDRKKKHEDSSPDTCPQGRKKKRGFFARYVHSGPKKTRGFFARYVHSGPKKHEILRSIRALRAEKKNEDSSLDTCTQSQKNEDSSPRYVHSGPKKHEDSSLDTCTKGRKKHEDSSPDTCTQGRKKSTRILRSIRALRAEKKNENSSLDTCTQSRKKNEDSSLDTCTQGRKNTRILRSIRALRAEKNTRILRSIRALRAEKNTRILRLIRALRAEKTRGFFARYVHSGPKTRGFFARYVHQGRKNTRILRLIRALRAGKTRGFFARYVHQGRKNTRILRLIRALRAEKHEDSSLDTCTQGRKTRGFFLLDTCTQGRKKTRGFFARYVHSGPKKTRGFFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ENJ1</accession>
    <name>A0A812ENJ1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_74085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005407">
        <property type="protein sequence ID" value="CAE1324331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ENJ1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="357"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="414"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="479"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1324331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="580" mass="67227" checksum="4041B97A2F3B450E" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EPB7</accession>
    <name>A0A812EPB7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_76793</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005498">
        <property type="protein sequence ID" value="CAE1327384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EPB7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1327384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="218" mass="25189" checksum="C5E2875A2FDAD29E" modified="2021-09-29" version="1">MFLDALSLSLFIYLSQVFLSFFLLHFPLSLTFFLNLSLPSLSLSLSLSLSLSLSLNPFSFSFHIFSFTICHIKYINLKRYFSLSLSLSLSLFLSLSFRFLFTFFIVYNVLFKVCKAVPQHLSLSLYLSIYLSIYLSLKLFLTLFILCLSIYLLFFSFLFLSLSLSLSLSIYLSISKAFSDSIYIMSFYLSLVFLSLLFSLSLSLSLYLSIYLSLKLFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EQ00</accession>
    <name>A0A812EQ00_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_75265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005454">
        <property type="protein sequence ID" value="CAE1325628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EQ00"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="298"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="348"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1325628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="406" mass="49076" checksum="9A868CB24A5CC468" modified="2021-09-29" version="1">MKKKSLYVLIFDTPTYLSIYLSIYLSIYLSMPVLSFLSFYNLNLCKSIYLSIYLSIYLSMPVLSFFLFFSFPFSSSFFLSFFLSLSFHNLNLCKSVYIYLSMSIIALFLFFFSFFFSSFFLFFLSFLSFFVFYIYLSIYVNYFFLSFVLFFPFLFSSFLLSFFLFLSFFLFFVISYFHYLSIYLSIYLSIYLSMPVLSFFLFFPFLFPLLSFFSFLSFFVISFFLCKSVYIYLSMSIIALFLVLFSFFFSSFFLSFFSFFLSFFLFLSFFLSQFFSFSFFFFLLFFLSFFLSLSFHNLNLCIIYLSIYLSIYLSMPVLSFFLSFFLSFFLFSFFLFVISYLNLCKSIYLCFIYVSRSSFFLSFFLSFFLSLYFHYLSIYLSVYLSIYLSIYLIVGTCFKYSSQYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EQ53</accession>
    <name>A0A812EQ53_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_77256</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005511">
        <property type="protein sequence ID" value="CAE1327865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EQ53"/>
    <dbReference type="OrthoDB" id="5973225at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024130">
        <property type="entry name" value="DAP1/DAPL1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15228">
        <property type="entry name" value="DAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1327865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="512" mass="52989" checksum="BEF72FA52DC0D752" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ERV9</accession>
    <name>A0A812ERV9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_76386</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005488">
        <property type="protein sequence ID" value="CAE1326790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ERV9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1326790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="211" mass="25335" checksum="48F309ABDF0E31E7" modified="2021-09-29" version="1">MIVFFPFLFIVFSFLYLLFFSCLVLFFSFIWSFFSVGFFFSFLCFLFFYHFLFLFFLFFCFSLFSLLFFLLSFSPFLFFLLFSIVFFCFFSVVFFLLFSIEIFLLYLYCLFLLFSIVFFSFFSIVFFLLSLSLLSFFSSLFLYCLFLLSLSIVFFLLSLSIVLFLFSLSIVFFSSLSFYCLFSPLSLLSFFFSLSLLSFFFSLSLLTFSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EZT5</accession>
    <name>A0A812EZT5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_80172</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005592">
        <property type="protein sequence ID" value="CAE1330912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EZT5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033008979" evidence="2">
        <location>
            <begin position="20"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1330912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="234" mass="26467" checksum="659D54071BE01DA4" modified="2021-09-29" version="1">MPFSKTFLFLSLVVMVVCCFLRPETKLVPNLVKSERNYVTNSPELADRDAQSVEFNASLEEKDNSTAASVGSTYHEKDHDGGSFSFSFSLFLSTLAFTSTDSFLISACVILFRKSTSTSSSHLAITVNRCILKLSLIPVRFSFFRGHVVSFFFLFFFFLTFYIYLMHEPNLYCCFTLTALCFIAPFSSSSLIFLSTSSLPTFPTRLSFLLPFLSYNPHLNLCLTFFSNPFPTHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AKN9</accession>
    <name>A0A812AKN9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000003">
        <property type="protein sequence ID" value="CAE1138671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AKN9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1138671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="214" mass="26130" checksum="983089263F99FEF6" modified="2021-09-29" version="1">MFFSFSFFIFSFRHFWDLLFFLQHFFLFLFLYTFQSLIVFFFFLFIYSHFYLSFSFFCSLFSLLSFSLIHTLSSLLSFFLSFSHIFSLLSTLLFIFPLPLICHLFSFSFRSFFLFFLFFFYYTTFFPFSFCFFPSIIKRINSFLFPTLNFSFCLSFHCELYLSIYLSIYLSIYLSIYLSLVISIYLSIYLSIFFSLVISIYLSIYLSIYLSIYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AL91</accession>
    <name>A0A812AL91_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_597</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000013">
        <property type="protein sequence ID" value="CAE1140518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AL91"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1140518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="215" mass="25216" checksum="0A201A01A38C0E79" modified="2021-09-29" version="1">MQLPHWEKIKNKTSTFVHFYFLFVVLCQCQSINQSNVCSIYYLSIYLSISFIHYILLTSIYLSISVCSYLSIYLSIYLSLFIHYILLTSIYLSIYLSIYLSLFIHYILLTSIYLSIYLSIYLSFKSDTLNLSVHYLSIYLSIYLSIYLSHSVHYLSIYLSIYLSIFKSYSQSIALLIIYLSIYLSIYLSIYLSIYLSHSVHYLPTSLGSLSIYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ALI9</accession>
    <name>A0A812ALI9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_2653</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000076">
        <property type="protein sequence ID" value="CAE1149221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ALI9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="309"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="333"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="424"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="451"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="487"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="517"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="554"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="580"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="613"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="640"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1149221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="750" mass="91316" checksum="C541E288B90FB2F5" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AN38</accession>
    <name>A0A812AN38_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NLK</fullName>
            <ecNumber evidence="2">2.7.11.24</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_1375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="2"/>
    <dbReference type="EMBL" id="CAHIKZ030000038">
        <property type="protein sequence ID" value="CAE1143751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AN38"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1143751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="249" mass="28885" checksum="91150C2BAA5AD3DE" modified="2021-09-29" version="1">MTAFHRCSGCAELIACFINYSSHLAILKSIVAASHLFLHQHSSSKYFSSSPTPRFTPPPPRTHFSTSSSSFSLFFSFLFTSSFSSSYPSLPPPHIHFHYLPPLHSTSSLPHSPLPSFYSSSTTFLQLPLLFYFLICLSLKEILAFLLIFFLLNFVFSFLFFHFPRLFVFLRLLMARPLFRFFFSFSSFYFFPPLFRFSLTFFFSFLLSSYSRFCFPPFSFVCSTSRFFSCSLPSNFFSFPLFSSLLFLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AU23</accession>
    <name>A0A812AU23_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_5455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000181">
        <property type="protein sequence ID" value="CAE1157992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AU23"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
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        <location>
            <begin position="68"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1157992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="259" mass="29797" checksum="A50EED6A460C6A20" modified="2021-09-29" version="1">MRSSLVYRCSPLEVNTDIGPIGYGSLQDSLRPQLLNSLVQILVSGFYLSIYLSIYLTAYLSVLYLDSFLLLSIYLSIYLSDCLSIRTLFRQFPVSIYLSIYLSECSSIYLLFIYLSIYLSIYLSIYLSELYLDSFRFLSICLILFNCLFLSVCLSIYLSIYLSIYVFSCLLIDCILFIAPSLSFSFSHSICSSPVYIYLSIYLSIYLPFLLSICFYLSILLSICSFFLSFFLLSFIKLFTSIYLSIYLSIYLSIYLCGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AV60</accession>
    <name>A0A812AV60_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NHL repeat-containing protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SPHA_5607</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000184">
        <property type="protein sequence ID" value="CAE1158499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273823at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14951">
        <property type="entry name" value="NHL-2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045302">
        <property type="entry name" value="NHL2_NHL_rpt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
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        <property type="entry name" value="Thioredoxin_8"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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            <begin position="134"/>
            <end position="154"/>
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            <begin position="174"/>
            <end position="198"/>
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            <end position="232"/>
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            <end position="273"/>
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            <end position="306"/>
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            <end position="373"/>
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            <end position="612"/>
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            <end position="646"/>
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            <end position="1177"/>
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            <end position="1213"/>
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            <end position="1616"/>
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            <end position="1718"/>
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            <begin position="1756"/>
            <end position="1777"/>
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            <begin position="1012"/>
            <end position="1043"/>
        </location>
    </feature>
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        <location>
            <begin position="1192"/>
            <end position="1239"/>
        </location>
    </feature>
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            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAE1158499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1783" mass="198999" checksum="5B7307C2BB373CE5" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AVA1</accession>
    <name>A0A812AVA1_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SPHA_7569</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000242">
        <property type="protein sequence ID" value="CAE1163097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AVA1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51225">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="557"/>
        </location>
    </feature>
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        </location>
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            <end position="622"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="629"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="7">
        <location>
            <begin position="299"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAE1163097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="659" mass="78217" checksum="56AAB67442B64077" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AVE6</accession>
    <name>A0A812AVE6_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Choline transporter-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SPHA_6511</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Farmed</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Choline transporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the CTL (choline transporter-like) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000213">
        <property type="protein sequence ID" value="CAE1160611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AVE6"/>
    <dbReference type="OrthoDB" id="420519at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007603">
        <property type="entry name" value="Choline_transptr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE (SLC FAMILY 44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385:SF14">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04515">
        <property type="entry name" value="Choline_transpo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="258"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="332"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="386"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="485"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="528"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="598"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="635"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="661"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="691"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAE1160611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="714" mass="81084" checksum="8772252186F70098" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AY06</accession>
    <name>A0A812AY06_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_7377</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000237">
        <property type="protein sequence ID" value="CAE1162650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AY06"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="305"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="335"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1162650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="383" mass="46090" checksum="F3A0FBEA96E3F900" modified="2021-09-29" version="1">MTHICFSFFFLSFFSFFLFSVIFTITSVCYSSFFLPIIFVMTHICLFFFLFRYFHFFLFSFSSHFFFFFFLSFFLSVIFTITSVYYSSFFPSHYLCYDSYLSFLSFFLSFFLSFLSFFFPLSFTITSVCYSSFFLPIIFVMTHICLSFFLSFFLSFLSFPLSLPSLLSTILPFFFPLSFVMTHICLSFFLFFLSFLFFLFRYLYHHFCLLFFLFSSHYLCHDSYLSFFFSFFLSFFFFSFPLSFTITSVCYSSFFLPIIFVMTHICLSFFLSFFSFFSFSVIFTITSVYYSSFFSSHYLCYDSYLSFFLSFLFSFFFFLSFFSVIFTITSVCYSFFFLPIIFVMIHICLSFFLSFFFFLSFFSLSLPSLLSTILPFSFPLSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AZZ9</accession>
    <name>A0A812AZZ9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_7521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000241">
        <property type="protein sequence ID" value="CAE1163025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AZZ9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1163025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="262" mass="32782" checksum="D85B950A029AA570" modified="2021-09-29" version="1">MFSYFLLFHISLFFFFSLNFSSSFLLLLRLLIPFFFSFVCFHHYKSPVFFLFFYSFYSFYSYIFSYFFFFYLLICYSFILLFCPFFYSLFLLLFSFLRSFHSIFIILLYSFILSFFYSFILLFCPFFYSLFLLLFSFLRSFHSIFIILLYSFILFFLLFFHSFILFILFFSFFYSLYSSILSFIFCIYSFIRLFFLFFYSIYSFILSFFYSFYLFYSFRSFIRFTLFILFILSFFYSFPSFIPFILLIILLFHSFILHSFIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B1I7</accession>
    <name>A0A812B1I7_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SPHA_8933</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000288">
        <property type="protein sequence ID" value="CAE1166526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B1I7"/>
    <dbReference type="OrthoDB" id="515401at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045165">
        <property type="term" value="P:cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000001">
        <property type="entry name" value="GATA transcription factor (GATAd)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000032">
        <property type="entry name" value="Transcription factor GATA-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039355">
        <property type="entry name" value="Transcription_factor_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071:SF281">
        <property type="entry name" value="BOX A-BINDING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071">
        <property type="entry name" value="TRANSCRIPTION FACTOR GATA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00619">
        <property type="entry name" value="GATAZNFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="13">
        <location>
            <begin position="49"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="GATA-type" evidence="13">
        <location>
            <begin position="103"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="156"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAE1166526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="292" mass="31345" checksum="1431D678B0C63CC7" modified="2021-09-29" version="1">MFRISFASSFPPLLFTAKKQESMIFLNGCWQDISLQENSSKYYGEIRHDAEGRECVNCGATSTPLWRRDGTGHYLCNACGLYHKMNGSNRPLIKPKRRLSAARRAGTSCANCGTTTTTLWRRNQNGDPVCNACGLYFKLHNVNRPLTMKKDGIQTRNRKMSTKSKKSKKGMTSMSDLLKPLDKPFPGSVYAPMHAPMATYMTSGSSLGGSFSSPVGSHMQASSGLSGSLSGGFTNSFNPSLTSQFTSSFPSIPSIPSISSSGLTLSTSSGMVGAMTSGLNLSTTTNMVGAMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B2V7</accession>
    <name>A0A812B2V7_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NmrA-like family domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SPHA_9581</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Farmed</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000306">
        <property type="protein sequence ID" value="CAE1167762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B2V7"/>
    <dbReference type="OrthoDB" id="300709at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF7">
        <property type="entry name" value="NMRA LIKE REDOX SENSOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="4">
        <location>
            <begin position="3"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00040296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAE1167762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="174" mass="20155" checksum="27CAE4AD5841E461" modified="2021-09-29" version="1">MVAKATIEEYMKNLALPLTCVIVPVCYEDFTKSYKPIRSPSTGIYESFIPMGLTPLDMISREDVGHIVAKIFQKRPKMLHKIISMSGDKLTMKQVADCLTNSLRPIEFKHKQITPNEFSKIHALDSASDVASMFSFLLRVDQRHWTETTRNIYPHVRSFQEWVTSNQNMLRRIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B3H3</accession>
    <name>A0A812B3H3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_9344</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000300">
        <property type="protein sequence ID" value="CAE1167332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B3H3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1167332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="235" mass="29268" checksum="E5B9020B4C8E041D" modified="2021-09-29" version="1">MKSIFNKDKFHVFLFLSFFLSFFLSHSLSFMLIRFLSFLLFSFSLSFFLSFMQILSFLSSLLLLSFFFILFFMLIRILSFLHFFLDFFLSFVFILILCSPFLSSSFFSFFFLSFFLSLLSFFLFFLLFSICILFLFHIFPMFYFYFHFFPSLFILSFFLFFFFFSFFLFHLHFFLFLLSFSFIHFFLFFFFFLSFFFLSFFLSFFVFFFPITKLGFFFLLFFFLFVGFKYYLLLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B6Z7</accession>
    <name>A0A812B6Z7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_11329</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000374">
        <property type="protein sequence ID" value="CAE1170980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B6Z7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1170980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="252" mass="29411" checksum="24BBA8E9C8B72361" modified="2021-09-29" version="1">MLNKHKCDEAGSCCRDNPTPRQSYSGTNGYPIYLSIYLSIYLSIYLSFTLFLLLFLLLLLLLLSFSFFFFFIPLSSSSSSSSSLFLLTPFVTDSVRDRPRSWQTPFVTDPVRGRLRSWQTLFMTSSVRDRPRSWQTPFVTDPAHDRLRSWQAQFVTDSVRGRLNSVRDRPLFVADSVRDRPRSCRLRSWQTLFMTSSVRDRPRSWQTPFVTDPAHDRPRSWQTPFVTDPAHDRLRSWQAQFVTDSVRGRLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B706</accession>
    <name>A0A812B706_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_12157</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000403">
        <property type="protein sequence ID" value="CAE1172580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B706"/>
    <dbReference type="OrthoDB" id="10069483at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1172580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="206" mass="23374" checksum="C3E234D1E63FF295" modified="2021-09-29" version="1">MKSTSRFVYSLKSTSPFVYNVKSTSHSSITWSTSRFIYSVKSTSPFVYSVKSTSPFVYSVKSTSPFFYSLKSISHSSLALKSISPFVYSVKSTSPFFYSLKSISPFVYSVKSTSPFVYSVKSTSPFFYSLKSISPFVYSVKSTSSFFYSLKSISPFVYSVKSTSPFVYSVKSTSPFFYSLKSISRLWRIILKIWKILKFIGKTSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B7S3</accession>
    <name>A0A812B7S3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_14599</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000500">
        <property type="protein sequence ID" value="CAE1177358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B7S3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="339"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="366"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1177358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="403" mass="47928" checksum="92B5E15498CD8757" modified="2021-09-29" version="1">MVDFFFPPSDCCSFLLSRLSRFVIVHWNRRHKIGVWLGHLLCDLLAVGNKRCDITEYLKCPYLPLFSLLPSFPPLSIYYILSPHHPLRHDSLSVSSLFPLLSSFLSLLHYRPSPIRLPILVSFDRRWRELNFSFFHPSLFTLDFFSLSLYMLDFSFLPFSSWISLFSLPFLFDILLPFSIFQLNFSFPVVCHFYSIFLSTEFSLSSLFRIDFLFHLSLFLAVPSPFEFLFPSPLIFFLFYFFFSFLFSPILLSLFPSLFFILLSLFLSLFSISLSLFPSLSFPFYFHFSPLSLFHFTFSPPYPFYFLLPRSRFSILLSLFLLSLLHFKFSFPAHFFPFYFLFFSSLFFILLSLLLFVSFFPLSLSPFLYLTSSFLDFIFYFLLFHHLLRKYHKIIVTIIIFFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B9I3</accession>
    <name>A0A812B9I3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_11675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000387">
        <property type="protein sequence ID" value="CAE1171640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B9I3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1171640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="266" mass="31846" checksum="56DEE6D167D92F4B" modified="2021-09-29" version="1">MSLNIENGNEACSDTMADGDLCLHCRYLYYLSIYLSIYLSIYLSIYIYIYMFKYGDVKILTSKPIYLSIYLSIYLSILFISIYSTSLFLVLFFISHLVHIYLSIYLSIYLSIYLSIYPCLFIIYLSISFGSISFPCVVFHISMLRSLIFYDAFLRCECRDKKLCRLSIYLSHLVHIYLSIYLSIYLSIYLSIYLSIYLSHLIHIYLSIYLSIYLSIYLIWFISIYLIWFISIYLSHLVHIYLIWFISIYLSIYLSIYLSIFHFFYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BAS0</accession>
    <name>A0A812BAS0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_13242</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000443">
        <property type="protein sequence ID" value="CAE1174734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BAS0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1174734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="171" mass="18812" checksum="78C6BD57F24878FB" modified="2021-09-29" version="1">MFITLSLSLETRSSLSLSLSRNAFITLSQTRSSSSLSLSNVHHSLSKRRVHHSLSLETRSSLSLSRNAFITLSLSKRVHHSLSLETRSSLSLSKRGSSLSLSKNAFISLSLNVQRSSLSLKRCSSSLSKRVHHSLSLSLSLCAFLANDHLFCKHIHLLLLPACLTPFPKCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BDE0</accession>
    <name>A0A812BDE0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_14596</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000500">
        <property type="protein sequence ID" value="CAE1177362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BDE0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1177362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="226" mass="24044" checksum="FAA1F8BB59506DF3" modified="2021-09-29" version="1">MSLSGRKCNYFFLLSSISFFSVFFGLLFTVLLFCPNSLSKIFLLFIASNSSPSIFSFYHVLRQCAHFLNLTTTSPSLETNTVPHPRPAAKTISPPLNLFILNLSPSLSLSLPPSLSPSLSPSLHLSLPLSISLSLSPSLSLSPSLSPSPSLSLSLSLLSHLSLPLISLPLSISLSPSVPLSIFSISLHLFPSLSPSLSSLLPLSLPLSISLPLSPSLSPSLHLSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BDF2</accession>
    <name>A0A812BDF2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MAFF_G_K</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SPHA_15433</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bZIP family. Maf subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000535">
        <property type="protein sequence ID" value="CAE1178747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BDF2"/>
    <dbReference type="OrthoDB" id="5974330at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14717">
        <property type="entry name" value="bZIP_Maf_small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000011">
        <property type="entry name" value="Transcription factor MafG, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004826">
        <property type="entry name" value="bZIP_Maf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008917">
        <property type="entry name" value="TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024874">
        <property type="entry name" value="Transcription_factor_Maf_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10129:SF48">
        <property type="entry name" value="MAF-S, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10129">
        <property type="entry name" value="TRANSCRIPTION FACTOR MAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03131">
        <property type="entry name" value="bZIP_Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47454">
        <property type="entry name" value="A DNA-binding domain in eukaryotic transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="9">
        <location>
            <begin position="47"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="65"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAE1178747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="234" mass="26384" checksum="93C19F313554D0E2" modified="2021-09-29" version="1">MSKKIFLSQVKSDNARLFDLSDEELVRLTVKELNQLVKGLNRDQVSRLKQRRRTLKNRGYAANCREKRISQKEELEIEREKLRAEVYRLQRENDVVKMELDSLRRKYDALQRLVLSLSLLANVFPFSLSLSAGQCLSFLSLSLSAGQCLSFLSLSLSAGQCLSFLSLSLCWPISFLSLSLSLCWPISFLFSLSLSAGQSLSFSLSLSLFAGQSPSSPLPPFPSLAPNLFPYLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BDH8</accession>
    <name>A0A812BDH8_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EFR3-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_15386</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EFR3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000535">
        <property type="protein sequence ID" value="CAE1178789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BDH8"/>
    <dbReference type="OrthoDB" id="19232at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049152">
        <property type="entry name" value="EFR3-like_ARM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051851">
        <property type="entry name" value="EFR3_Homologs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12444">
        <property type="entry name" value="PROTEIN EFR3 HOMOLOG CMP44E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12444:SF8">
        <property type="entry name" value="PROTEIN EFR3 HOMOLOG CMP44E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21052">
        <property type="entry name" value="EFR3_ARM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1178789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="799" mass="90850" checksum="AB6543EB2615FBA3" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BDL6</accession>
    <name>A0A812BDL6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_14742</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000506">
        <property type="protein sequence ID" value="CAE1177658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BDL6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1177658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="198" mass="21541" checksum="A7680BE1ED7370DF" modified="2021-09-29" version="1">MSAVLVATSTYWSMKHSGSVAYWLLLSAVLSGISFANFGYPTPKAMADEMSNLAKLDRYNLAKNHGPQYHINLSFSFFLSLSLSLFVLAPCLSCIAFNITLTNFVKIRNAGFGLFSLSLSLSLSLSLSLSLPPSLSLCLFLSLFLSPTSVSIYSRILSFFNKSSLSYQSLSLSLSLSPSLSLSLFLSAFFLLSELCCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BE16</accession>
    <name>A0A812BE16_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">2-oxoisovalerate dehydrogenase subunit alpha</fullName>
            <ecNumber evidence="9">1.2.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SPHA_14958</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Farmed</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + 3-methyl-2-oxobutanoate + H(+) = N(6)-[(R)-S(8)-2-methylpropanoyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:13457"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10497"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83142"/>
            <dbReference type="EC" id="1.2.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the BCKDHA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.4" evidence="9"/>
    <dbReference type="EMBL" id="CAHIKZ030000515">
        <property type="protein sequence ID" value="CAE1177987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BE16"/>
    <dbReference type="OrthoDB" id="3845at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003863">
        <property type="term" value="F:branched-chain 2-oxo acid dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009083">
        <property type="term" value="P:branched-chain amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02000">
        <property type="entry name" value="TPP_E1_PDC_ADC_BCADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000015">
        <property type="entry name" value="2-oxoisovalerate dehydrogenase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050771">
        <property type="entry name" value="Alpha-ketoacid_DH_E1_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43380">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43380:SF1">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 9 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="430"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="455"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="486"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="529"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="563"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="590"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="domain" description="Dehydrogenase E1 component" evidence="11">
        <location>
            <begin position="105"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAE1177987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="614" mass="70516" checksum="255B87BB6E2E2867" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BG28</accession>
    <name>A0A812BG28_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_16006</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000558">
        <property type="protein sequence ID" value="CAE1226375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BG28"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1226375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="157" mass="17707" checksum="1BA0B29AEEABC33A" modified="2021-09-29" version="1">MCNLDQCPSVIGEINGQSRPLPLCLWRNQCAISTTDSLLLVKSICNLDHCVFVFGEINVQFLPRRVCLWRNQCAISTNASLSLAKSMCNHDKCLSVFGEINVQSRPRRVCLWRNQCAITTTASLSLLKSMCNLDQSVSVFAEINVQSRPRQVCLWRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BJ85</accession>
    <name>A0A812BJ85_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_18540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000669">
        <property type="protein sequence ID" value="CAE1232520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BJ85"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032751643" evidence="2">
        <location>
            <begin position="21"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="287"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1232520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="339" mass="39519" checksum="69115FCDC0C36632" modified="2021-09-29" version="1">MSRWGLSLLLFCHLFLNFLTFPCCFSPHTFPCCFFPLLSLFGLSFNLLTLFRLSFSLLALFLLSFLLLALFHLPFPLLALFPSFIPSSHPFPSFIPPSSPFPSFFHSSHTFPSFFPPPRPFPSFIPPSRPFPYFIPPSRPFPYFIPLSLFFFPLLTLSCLCFPLLTLFYLSFPLLYVFHLSFPLLILFHLSFPLLALFHLSFPLFVLFRLSFPFLAFFRLSFPLPVFFHLSFHLLALFRLSFPLLCLSFPLFALFRLSFPLLTLFHLSFPLLTFPSFIPTSRPFPSFFPLSLFYEFLFFLLSLFLCFFILLLSLFRASSSLFCTPLSLFSMLFPHSLFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BKJ5</accession>
    <name>A0A812BKJ5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_18382</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000664">
        <property type="protein sequence ID" value="CAE1232096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BKJ5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1232096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="343" mass="41886" checksum="F26205AD6DA5B0EC" modified="2021-09-29" version="1">MLFPELFAFLSPYSRSFRFPTNFFVSGGIYFSFLFFFFFFHLLSFFFSFFLSSFFLSFTFFLLSFFFLSFFFLSFFLSSFLSFIFLSFFHSPFFFLSFFLSFTFFLSFFLSFFLSFFLSFFLSFFLSFIRYFFFLSIIPQYLPSNFPIFFCFYYFISFFLSFFLFLSFFLSFFLFYIDFISFLISIKFTLSFPTYFSSLLLPPFFNLFSFCSHQTTITLFFFFHCIILFLLTFYYFLLYSLYFLFAFLSFFLSFFLLSIVSFSTFHSFHTSFIFFLCLSFFYQKHDFLSFSVIFPTSFFLSFFFRLFYLSIYLSQYVLISLSILVPALDKVHISFSENLSFPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BRA7</accession>
    <name>A0A812BRA7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_22522</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000834">
        <property type="protein sequence ID" value="CAE1240856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BRA7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="299"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="361"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="390"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="422"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="452"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1240856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="482" mass="54340" checksum="97F4FADE47F4BAA5" modified="2021-09-29" version="1">MHKRTRISLPPFSTPALSSHSFLSLFALCTLCLSNSLTLSLSPSLSLPLSLSLSHAIISLYCYQLLFFMSYLSIFYALFVFPHFLSESFVSLSLSFSLSLSFTNTSSHSLYFYLHSFATFSLYLYSLFISFFSPFSTSHYTQSFFHRLICLLSVTRTFFLQFLSLSLSLFRASVSTTLSSTSIFSLYPSLSLSLSLSLSLTLLKHSGILPTPPSHFNIFLLSVLKLFLTPSNSFSISLPVFTPHFSLHPITLFFVSLGHFPDNLSLFPPSLSLTCLLNPFAFPSTHFTLSFSLSRFRAFCLHSLAIPVAPALSLFPLHILSLPLTHTARFSPLYLSFFISFRLHLSNFSLSILHSLFFSRLYILFLSYFIAPSISLFLSPSLSLSLSLSFSSQFHITLFLSCFSSSYSCLSNLSFFPHPLPLIFFLILLNVFLISQNLWVTPNVSKESSICYSISVILSIYLSIYLSIYLSIYLSIYLSIDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BTT0</accession>
    <name>A0A812BTT0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_25218</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000954">
        <property type="protein sequence ID" value="CAE1246536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BTT0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1246536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="319" mass="36865" checksum="65F860CD5CA3653E" modified="2021-09-29" version="1">MVGSSSFNNVSNIFFFFFFFFFFFFFFFFFFFSSSSSFSINLFCMNSFFLTDLRFFLPPLCRSILFIGLPIHLYFQNSPDFPSLPLFLSLSPPPTITFSLSPSISLFLSLTLSLSLPTTLSLHLHTHISIYLSIYLSIYLSIYLSISLYIYIISSCRSLSFFLSFFLYDCLKAYEGDRTSQWPKCCQNSKSTDISLHNYSSQNFTLGKSYFTIYPVVHRRLMILLMHLSWATPIHLASFRSFNVSILGNYSAPSQLLILLIIYPGQQQCPASDPSNVSILGNIDTPRQFPILLMYLSWATTVHLASFFKNNSFYFRRNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BY49</accession>
    <name>A0A812BY49_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">VPS39</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SPHA_26272</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VAM6/VPS39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001003">
        <property type="protein sequence ID" value="CAE1248728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5325112at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000298">
        <property type="entry name" value="Cyt_c_oxidase-like_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032914">
        <property type="entry name" value="Vam6/VPS39/TRAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019452">
        <property type="entry name" value="VPS39/TGF_beta_rcpt-assoc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894">
        <property type="entry name" value="CNH DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894:SF49">
        <property type="entry name" value="VAM6_VPS39-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10366">
        <property type="entry name" value="Vps39_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00036">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50253">
        <property type="entry name" value="COX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="546"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="572"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="603"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="632"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="662"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="690"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="719"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="748"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="778"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="808"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="833"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="862"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="889"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="918"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="947"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="977"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1347"/>
            <end position="1370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1382"/>
            <end position="1404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1424"/>
            <end position="1445"/>
        </location>
    </feature>
    <feature type="domain" description="CNH" evidence="6">
        <location>
            <begin position="17"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="Heme-copper oxidase subunit III family profile" evidence="7">
        <location>
            <begin position="672"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="4">
        <location>
            <begin position="1026"/>
            <end position="1206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAE1248728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1636" mass="192199" checksum="62E878192FD4A31A" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BZ55</accession>
    <name>A0A812BZ55_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_26734</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001021">
        <property type="protein sequence ID" value="CAE1249716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BZ55"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="363"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1249716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="384" mass="44686" checksum="541A4F5C99521515" modified="2021-09-29" version="1">MSPAEHSMIQGTVESFAFAYPFFFSKKCPFPLFLSPFSFDFSFFLSSFLSSFLLTLLLTILLTSYSLLFSLFTPYSLLFALLTPYSSYSLLLTLLTLYSLLFTAYSYYSLLLTFLTLYSLLFTPYSSYSLLFLLFTPYSLLLTLLTPYSSYSLLFLLFTPYSSYSLLFLFLTLLTLYSLLFTPYSSYSLLLTQLTLYSFLFLLLNLLVTTYSPIYLTPYNPPYSLYSFNISFSYFYSLTFSISYPLFLFPLFSVTHSLFITFFPPFYLSVISFALSSLFFLFSHFLILFLSRLDFLSSLFFSSRSHTHFHSLFLSPAYFLFRSLSLTHFSFTPSYSVILLFSLFRCLQLFSLLLSSFPPLLTFFLLFSSLNLFSLLFFLSFSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C1R8</accession>
    <name>A0A812C1R8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_29716</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001189">
        <property type="protein sequence ID" value="CAE1255629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C1R8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="304"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="332"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="392"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="420"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="447"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1255629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="488" mass="57451" checksum="04EA738F3FF47560" modified="2021-09-29" version="1">MLKINANLKIIKFCLIYYILSLPLLIFLSFLSFFLSFFLSFCFFIDFSFISFFFFLSFFLSFFLSFCFFINFSFFFLSFFLSSFFLSFFLFLYKCFFHLFHSFFLFLKILFLSSSVLLFIFLPSDFYSPRFYFLSSSVHLFILLLSSFYLTLFFILSSSLHFILLGYTFFILRSSFYPPPFFLLPSSLLLFILLRSSFYLPNFFFLSSSLLFILLGSTFYPPFFFLSSPFFFLSSSLFLFILLPSSFYLPLFFILSSSLLLFILPLLLFILLPSSFYLPLFFILSSSLLLFILPLLLLSSSLLLFIFLCFFILSSSLLLLSSPFFFFYPPPFFFFIFLCFSFYPPPFFFFILPLLLFILLPSSFYLPLFFILSSSLLLFIFLCSSFCPPPFILFSSVPLFILPLLLFILPLLFILLPSSFYLPLFFILSSSLLFIFLGSTFYPPPFFFLSSSLLLFIFPRSCFYTFPAHYIQSYTLLSFSVASCQLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C3A3</accession>
    <name>A0A812C3A3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_31668</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001305">
        <property type="protein sequence ID" value="CAE1259381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C3A3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1259381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="154" mass="17067" checksum="ED6513D259C8401A" modified="2021-09-29" version="1">MTAAPSDTSRYQSGAHVFTWLASRPSCYLSLSLSLSLCVICLQIMADHCSPHLSSFIAQSNSCLFTNTLSLRDLCSINCFVIVPVDLDFGDIFFSRINANARKSIFACQTRNCIISPLASRLLFPFLLLSYLSLSLSLSLSLSIYLSIYLIYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C502</accession>
    <name>A0A812C502_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_27208</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001046">
        <property type="protein sequence ID" value="CAE1250581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C502"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1250581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="401" mass="43676" checksum="5251E4E082F4B92A" modified="2021-09-29" version="1">MTTPFRSRPPVCPRSNPVANREVGDFDPNPFLAHVVFIFTTKQTRIELSLDWCRSESLNYGILTKHSPPSPPPLSLSLSLSLSLSLCHPLSLALSLSLFCFLCPGISAFMESNLQNPGWVDLFGDASGSPVNQSNLSPGYRGAHPAGVAVGTRRSAILFSYLLLLVPHTSTFQLVYSFSSYFLISASHAVIHPGNRCSTRHVSSGSELRNTDEALATLSPHSPPLSLSLSLSMSSSLSRSLSLSLALSLFCFLCPGISAFMESNLQNPGWVDLFWDASGSPVNQSNLSPGYRGAHPAGVAVGTRRSAILFSYLLLLVPHTSTFQWVYSFSSYFIISASHAVIYPGNRCSTRHRNVLPPAESTSDIESFLFPFLRPPVAIKLLFVTRLMVSVKNRIHPLGFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C505</accession>
    <name>A0A812C505_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Serine/threonine-protein kinase 11-interacting protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SPHA_28420</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001113">
        <property type="protein sequence ID" value="CAE1253379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7451790at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057288">
        <property type="entry name" value="PH_PLEKHM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057292">
        <property type="entry name" value="PH_S11IP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057676">
        <property type="entry name" value="PH_S11IP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454">
        <property type="entry name" value="NISCHARIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454:SF69">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 11-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23142">
        <property type="entry name" value="PH_PLEKHM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25357">
        <property type="entry name" value="PH_S11IP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25624">
        <property type="entry name" value="PH_S11IP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52075">
        <property type="entry name" value="Outer arm dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Serine/threonine-protein kinase 11-interacting protein PH" evidence="7">
        <location>
            <begin position="574"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="domain" description="PLEKHM2 PH" evidence="6">
        <location>
            <begin position="1021"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="domain" description="STK11-interacting protein C-terminal PH" evidence="8">
        <location>
            <begin position="1193"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="386"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="458"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="770"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="947"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="388"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="402"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="415"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="471"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="782"/>
            <end position="798"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF25624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAE1253379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1337" mass="151012" checksum="DA5826A195B9340E" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C6Z7</accession>
    <name>A0A812C6Z7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_29602</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001180">
        <property type="protein sequence ID" value="CAE1255450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C6Z7"/>
    <dbReference type="OrthoDB" id="121932at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032072">
        <property type="entry name" value="DUF4807"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36693">
        <property type="entry name" value="GH02722P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36693:SF1">
        <property type="entry name" value="GH02722P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16065">
        <property type="entry name" value="DUF4807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1255450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="242" mass="28012" checksum="BE91A8E8175BA6F6" modified="2021-09-29" version="1">MCLTLDSHVASCAAHELALSRIFRKKFLKYAKSKVGLSHSFNNVDDHEDVKLVWIPFVIEIQLEYPKQKIDYSWFYRIQSLVILKLKTEESMALLSTLGGGFSALGDYYEKHSLEAGKIALRQLKIAFMICDPLIAARCYLYIALSLMQRGYLKKSKLIIRKQYSFAKDHFIKDYRLIAMCRGLWSRLQFMYYLHRLKRQGIACSVQHGVLTEYYSDYNTCNAWSQTSGQDENRISVDLGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C784</accession>
    <name>A0A812C784_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_29631</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001181">
        <property type="protein sequence ID" value="CAE1255484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C784"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="332"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="369"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1255484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="416" mass="48414" checksum="EE358D2ECEE2942C" modified="2021-09-29" version="1">MLPYYFFLSSRFYPLWLPHEHIFSISIFFLAIVVYGNDDDDVESFSTLSLSFFLIQIFFFCYSISFSSSSSCSCLGPLTTFFLLSSFCFLLIFSLSLSLFLSFIHFLSLFLKYKLFSLFFLNLFFLLSTKNSSYFLFFFIKLFTHFLSLSLCFFLFFFIKAFYSFSLSLSLCFFLFFFIKAFYSHALFIYIISLFFFSTSSSSSKYTEIFSPPLKCNVQQHNSLHCPTFFFSLSFTLHPLPTFEISFFSTKPFTVCNSFFISTLLFYLSFLASPFPICDAATFIAHTLLLLPPPPYSSCDINSITGVTPLWPVLTTWIPLKKSGVCTINSYGLVRYLIYFLSCYIFFLLPKYPNYLWNSSISTSFHNLFPLSFIIPFSPSLTWSSAGLHLSVAVHRQFAPIKLLHFLMQYFKDKTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C7V7</accession>
    <name>A0A812C7V7_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_30028</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001205">
        <property type="protein sequence ID" value="CAE1256192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C7V7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1256192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="166" mass="18523" checksum="6CC17CB9707A61C2" modified="2021-09-29" version="1">MLLRHDTKRDTSSAYAETLARAPRRAGLFARPLSGEEEAPTPKKKNYLFFSFFLSFFLSFFLSFSSPSRPPTARGVRLFNATATTTMIFLEVLISDSPLDRLTATTVSLSFSLSLSLSLSLSLSQRHSRLTPKSLQLSKNSRLYSKPKVISQVVHALNRSVAISKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CCJ9</accession>
    <name>A0A812CCJ9_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_31715</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001311">
        <property type="protein sequence ID" value="CAE1259502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CCJ9"/>
    <dbReference type="OrthoDB" id="6142482at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1259502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="188" mass="21879" checksum="AD82B86563E34726" modified="2021-09-29" version="1">MDNGAAFRSEVFRSMLDKWKTRQYYRAAYSPSGNGIVERNHRTIKVIAERGGISPAEAVFWYNMSPKSGQREDTVPHRAVYTYQWRHPRVGSCLTRSDGPESIRIGEEVWVKPTGARCTTKWTRRMVTGAQSRINVEVDGMPRHILDLRVIQEDLENEGDNWRSSHEAQPKTLRKSQRERHPPRWNDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CFL6</accession>
    <name>A0A812CFL6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="14">ATL</fullName>
            <ecNumber evidence="14">3.6.5.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SPHA_34918</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Farmed</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="14"/>
    <dbReference type="EMBL" id="CAHIKZ030001493">
        <property type="protein sequence ID" value="CAE1265876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CFL6"/>
    <dbReference type="OrthoDB" id="7788754at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01851">
        <property type="entry name" value="GBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003207">
        <property type="entry name" value="ATLastiN (Endoplasmic reticulum GTPase) related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:004169">
        <property type="entry name" value="Atlastin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.420:FF:000001">
        <property type="entry name" value="Atlastin-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.420">
        <property type="entry name" value="AHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030386">
        <property type="entry name" value="G_GB1_RHD3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003191">
        <property type="entry name" value="Guanylate-bd/ATL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036543">
        <property type="entry name" value="Guanylate-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015894">
        <property type="entry name" value="Guanylate-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10751">
        <property type="entry name" value="GUANYLATE BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02263">
        <property type="entry name" value="GBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02841">
        <property type="entry name" value="GBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48340">
        <property type="entry name" value="Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51715">
        <property type="entry name" value="G_GB1_RHD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="422"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="449"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="GB1/RHD3-type G" evidence="13">
        <location>
            <begin position="36"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAE1265876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="515" mass="58408" checksum="E27D6E4E5187658C" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CH62</accession>
    <name>A0A812CH62_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_33542</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001405">
        <property type="protein sequence ID" value="CAE1263022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CH62"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1263022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="378" mass="43450" checksum="B2CADC90B72BC485" modified="2021-09-29" version="1">MTHKKRSGANRTPEFLTDVSLHFFTVPLIAQLIAPAHHQIEILSSISVLEKEVNGRPNNTKEALKAANRNAMANMDQENRLKNCSSLRSRLEKWEAADDDFFSNCFFISSLLRFFPYGLFHFPSMIAFFFHISYYLAPFLFFFLFNVSSIFSSLMSFRIFRCFLGFFHSPTIIPLSFHLSFFLPLVSFYFSGLNQSSSVISSSFHLSLCFHFVSFHSCRPFQSPSMIRLLFHLSNCLSDRLFSFLWPFSVSFYDFSSLFMPVAFLQSPSLIRPPFHLSNCLSACRFSFLSSLFIPVAFLQSPFMTRLLFHLSNCLSDCLLSFLSPFQSPSMIRLPFHLSNFLSARLFSFLSPFSVSFNVSPSLSPLQSFPLMISFSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CHJ8</accession>
    <name>A0A812CHJ8_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">UDP-glucose 4-epimerase</fullName>
            <ecNumber evidence="9">5.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SPHA_35865</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Farmed</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP-GalNAc when exogenous sources are limited. Both UDP-sugar interconversions are important in the synthesis of glycoproteins and glycolipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>UDP-N-acetyl-alpha-D-glucosamine = UDP-N-acetyl-alpha-D-galactosamine</text>
            <dbReference type="Rhea" id="RHEA:20517"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:67138"/>
            <dbReference type="EC" id="5.1.3.7"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 9">
            <text>UDP-alpha-D-glucose = UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:22168"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="5.1.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 9">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 9">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.2" evidence="9"/>
    <dbReference type="EMBL" id="CAHIKZ030001557">
        <property type="protein sequence ID" value="CAE1267960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CHJ8"/>
    <dbReference type="OrthoDB" id="9402762at2759"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003974">
        <property type="term" value="F:UDP-N-acetylglucosamine 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose, Leloir pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05247">
        <property type="entry name" value="UDP_G4E_1_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005886">
        <property type="entry name" value="UDP_G4E"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01179">
        <property type="entry name" value="galE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007956">
        <property type="entry name" value="PRK10675.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43725">
        <property type="entry name" value="UDP-GLUCOSE 4-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43725:SF47">
        <property type="entry name" value="UDP-GLUCOSE 4-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01713">
        <property type="entry name" value="NUCEPIMERASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="8 9 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 9" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="10">
        <location>
            <begin position="23"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00002760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAE1267960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="362" mass="40039" checksum="7FAB2EED92A885EF" modified="2021-09-29" version="1">MVVIPPELTSMTVVSQRYTMSVLVTGGAGYIGSHTVVELINAGYDVVIIDNMVNSCKESIKRMEEITGKTIPCFEIDLLNKEALNAIFQKHNFSIVVHLAGLKAVGESCDLPLLYYKNNVGSTLNLLEVMKENGVYNIVFSSSATVYGIPQELPINESHPQGSCTNPYGQTKYFIEVILHDLSKTDKKWNMILLRYFNPVGAHKSGKIGEDPNGIPNNLMPFVAQVAIGRRSELKVFGNDYDTPDGTGVRDYIHVVDLALGHVAAVNKVEENCGYKVYNLGTGCGYSVLDMIKAFEKASGKSIPYKVVDRRAGDIASCYSDASLAAKEMGWKAKYGLDEMCQDLWNWQSKNPYGYKKKENED</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CKB1</accession>
    <name>A0A812CKB1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">OTUD3</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_37535</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="CAHIKZ030001671">
        <property type="protein sequence ID" value="CAE1272106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CKB1"/>
    <dbReference type="OrthoDB" id="6095088at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22755">
        <property type="entry name" value="OTU_CeDUB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050704">
        <property type="entry name" value="Peptidase_C85-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419">
        <property type="entry name" value="OTU DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419:SF7">
        <property type="entry name" value="OTU DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OTU" evidence="2">
        <location>
            <begin position="105"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1272106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="237" mass="27689" checksum="9086B08AAB726380" modified="2021-09-29" version="1">MRICNRFSNSRRNQPTASCSMHRKPVKTNAGQRKSLSDSELPEDVEFYDELFRRDFALGQGSRNMAEEPDMSSLSLRAAEQSMEFPLIELLEIYRRQHGLECQSLKIRPQERDGNCFFRCLSDHFTGRPDNHLVFRKLVVEYLKSLYIDRHPVPLPEISVEEHVEYMLQPNTWATECEIYAAAHMFNLRIDILTGGRGSPYMWATTVPIDADPSSVLKCLRLLHRDRVHFDLIQEEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CKH7</accession>
    <name>A0A812CKH7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_37275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001661">
        <property type="protein sequence ID" value="CAE1271563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CKH7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1271563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="281" mass="31894" checksum="7596A5D912607CCE" modified="2021-09-29" version="1">MFFIPPLPILLFFLFHFLVVSFFSTPSSFYPVFLLLSFPSSSLLLPPLLLLHLSSYTFIISPSSSPPSSSSSTSPLYPFQLLFSPHPLLSFQSYSSLLPPLLFLHLPSYTLIPFPVLIPSVFLFFHLSSLSFPTFILSSSSLIFSIFLFSSSTAPLPPPLFLNFDPLPCLHPLRLPLLSPLLFLHLTFYTFIPVFIASYPFRFPLLYPFHFLSSSSSTSSFPISLSPPLLFHLLSFYSSPPSVFPLLNLFFLILFNFLTGAYFLILSFALFFFFIHHFVFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CM12</accession>
    <name>A0A812CM12_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_37281</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001661">
        <property type="protein sequence ID" value="CAE1271560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CM12"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1271560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="355" mass="42545" checksum="3102BDEAA6D2411A" modified="2021-09-29" version="1">MFLLCFYVSFMFLLDIYVSFMVLCFFYVSFMFLCFFHVSSLYLSFLCFFYGSMFLLYLFYVSMFLLCFFNVSMFLMFLLQFYASSVFFTVLCFFYVSPIFLLSICFFYFSMFLFLLCFFDVSMFLLCFFYICMFLIFLLWFHVSSISEFLICFFNISVSLLCFFSVSYVSFMFLCFFYVSMFLLYLSMYLLLLRHFYLSVSMFFVCFLHISYVSSMFNLCFFVSFIYLMSLCLFCLSSIFLRFLYVSILLLCFFDVSTFLHSFVLLPFNYISSVLQIHFCLQAKCQIVHRFTYISLTSKFFFFLPPQFISSFDFSHRFSSFSSFSSIILSLYGSDFLSLSDFLSLSMSLIFSLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CMT4</accession>
    <name>A0A812CMT4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_36930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001631">
        <property type="protein sequence ID" value="CAE1270169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CMT4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23304:SF189">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23304">
        <property type="entry name" value="SPOT2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1270169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="242" mass="28791" checksum="E063319B32175A68" modified="2021-09-29" version="1">MSWFSIFSIENVRGKVVDPETWIKQQYGKGYTLFSGEGSVRFPYYYTYAILKTTFKCFHIYLSIYLSIYLSIYLRQFLSIYLSIYLSIYLSIYLSIYLSIYFVYIYLSICFVHIYLSICLSIYLSIYLSIYLSVFVYIYLSICFCSYLSIYLSIYLSIYLSIYLSIYLSQSIPIYLSQSVSIYLSIYLSIYLSILSIYLLARWTLIFIRMYFVKCSHRLVKSSLTNITCASLFYEMISKNEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CNE7</accession>
    <name>A0A812CNE7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_37741</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001691">
        <property type="protein sequence ID" value="CAE1272547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CNE7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1272547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="234" mass="27318" checksum="7C1EB5FD6A54A3DA" modified="2021-09-29" version="1">MSCPSSHMAIRSASTSISSSNVSFFFFFFFVFLYAFFQFFWLIVCFSSSSSSSSSSFSSSSSSSSSSSSSSSSSSLYSYIHFYSVLLVNRMFFFIIIFFFYYYYYKYFSLSYIFQYLTHFATIFSFSLFYSLSSSHYFTPFPTHKISMPLLPTLFYSLSQKYYITRFPSDSEQLIPLHTNTALLFLRSLPFYSLSYTNYFLPLLPIVTSLHSLTRFYPFSTFTLCHKHPIFARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CP07</accession>
    <name>A0A812CP07_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">FCHO</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SPHA_40743</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <location evidence="1">Clathrin-coated pit</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FCHO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001935">
        <property type="protein sequence ID" value="CAE1277619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CP07"/>
    <dbReference type="OrthoDB" id="5593455at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048268">
        <property type="term" value="P:clathrin coat assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07648">
        <property type="entry name" value="F-BAR_FCHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054713">
        <property type="entry name" value="GMIP/FCHO2-like_FCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018808">
        <property type="entry name" value="Muniscin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065:SF15">
        <property type="entry name" value="AT02057P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065">
        <property type="entry name" value="PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22699">
        <property type="entry name" value="GMIP-like_FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10291">
        <property type="entry name" value="muHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0168">Coated pit</keyword>
    <keyword evidence="4 6 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-BAR" evidence="10">
        <location>
            <begin position="5"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="MHD" evidence="9">
        <location>
            <begin position="647"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="261"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="341"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="494"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="171"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="290"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="341"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="494"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="517"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="559"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="573"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="627"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAE1277619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="923" mass="102199" checksum="E12139595FAB2D4E" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CPY6</accession>
    <name>A0A812CPY6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_38851</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001782">
        <property type="protein sequence ID" value="CAE1274387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CPY6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1274387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="279" mass="34037" checksum="F57A2AE2812EE70A" modified="2021-09-29" version="1">MIFSLSLINIKISYFYHSISKYICMCPIFKSIYLSILVCSLSIYLSILACSNLSLYLFILVYSYIYLSIYLSILVCEFFLLLSFSLNFSFFFFLSFFSFFLFFSFSSHFNLSFLSYGGFAFSFFFFLSFFFLSFFLFFFFLFFLSFFLFFSFVVSFTFLFYFFSFSFVFLLFFFLFFYFGFPLLLFFLFFFLFFSFLSFLFFLSFIHFFSFSLFIGLFVFLFSFFLSFRSFKTFSFFLSFFLYFSLQIFSYGGFPLLLFLSFFRLFLSLIFFSFFSYGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CS29</accession>
    <name>A0A812CS29_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RNF34</fullName>
            <ecNumber evidence="9">2.3.2.31</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SPHA_39114</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="9"/>
    <dbReference type="EMBL" id="CAHIKZ030001802">
        <property type="protein sequence ID" value="CAE1274790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CS29"/>
    <dbReference type="OrthoDB" id="3045089at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902042">
        <property type="term" value="P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070936">
        <property type="term" value="P:protein K48-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15750">
        <property type="entry name" value="FYVE_CARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16500">
        <property type="entry name" value="RING-HC_CARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000110">
        <property type="entry name" value="E3 ubiquitin-protein ligase RNF34 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051728">
        <property type="entry name" value="RING-FYVE_E3_ubiquitin-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055111">
        <property type="entry name" value="RNF34_RFFL_HeH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057299">
        <property type="entry name" value="RNF34_RFFL_SAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14879">
        <property type="entry name" value="CASPASE REGULATOR, RING FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14879:SF15">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RIFIFYLIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22968">
        <property type="entry name" value="RNF34L-like_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23632">
        <property type="entry name" value="SAP_RNF34_RFFL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="8">
        <location>
            <begin position="40"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="291"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="154"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="185"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAE1274790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="338" mass="38440" checksum="1707D6AA38A2730E" modified="2021-09-29" version="1">MGAGVVKAQEQWAHPINITTTTTAAAQFSPNSEEGLLLSNRTNMSCESCAVQFTTFKRKKTCYHCGRHFCSSCCQRQWNNIQLNRQCRKCQILTSGNFTRNDLMQWKVKDLQVFLRKKNISTSTCTEKHDLVELLLRHFGNYIEYQTNIDTQLDQQNSQTAHVPPSSNNSDSTEGRAGEDVQPLSGSSSWNSSNGSQRQTQEPDVDVQSAVSPNFSPSKPAYMNLDTFENIEAVANLTVKELKEILSFHFVDYKGCVEKWELLDRVRRLWEEQKQQKKDLESPVSNEEETCKICMDATIDCVLLECGHMVSCTQCGRKLNECPICRQFVVRAVHIFKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CU78</accession>
    <name>A0A812CU78_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_43566</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002191">
        <property type="protein sequence ID" value="CAE1282591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CU78"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="273"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1282591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="356" mass="40200" checksum="6C8ACC067F43B97E" modified="2021-09-29" version="1">MLIFIIVCALSISGCHIYLSIYLSIYLSIYLSIYLSILRAINMDNTYICSKKERKQKEEKRSFFQVESSSVNYSLSFSHSFSLSLSLSFSRFLSLSLSLPLSVFFSLSIYLCLSFSLSLSFPFCLSLFVFLFLSFTFLSLSLSLSDFLSFSVSLYLFLSLCISLSFTYCFSIPLSVFLSFSFTYFFSPIFSLRLSFSCLSLSHSLSSSLSLFSLYLSHSLSVFLSLCLSVSFSISPILSVLLSLSFSLSFCLSLSLFHFSLPVFLSDFLSFSVSLYLFSLSVFLSLSPTVFISPFLSFSLSFFLSPSLSLFLSLFLFLLSLSVFQILSILSAFLSLSFSYCFPLFFALFLFFSLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CVS8</accession>
    <name>A0A812CVS8_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">WD repeat-containing protein 44</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SPHA_42475</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002085">
        <property type="protein sequence ID" value="CAE1280715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CVS8"/>
    <dbReference type="OrthoDB" id="20550at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040324">
        <property type="entry name" value="WDR44/Dgr2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14221">
        <property type="entry name" value="WD REPEAT DOMAIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14221:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="548"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="77"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="351"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="448"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="600"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="77"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="115"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="132"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="158"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="191"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="351"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="603"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00021207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAE1280715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="623" mass="68781" checksum="4964A3BB7C9167BA" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D5V3</accession>
    <name>A0A812D5V3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_46650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002479">
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            <end position="404"/>
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            <begin position="410"/>
            <end position="427"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1287565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="428" mass="51771" checksum="6A31D28E3AC0B0F7" modified="2021-09-29" version="1">MRESRLLYRRVQTKIHELFPLDHPKLFRQKFSYSLSVTSDPKRVNPVTTFCTRSTQYLSIYLSIYLSRLFNVECFGSVVLSFFLFSFFLSFFLYLFISPFLSFFLSFFLFFSFFLSFFLSFFSFFFSRNSPLSMKYWQDLPFFLSFFFSFFLSFFLSFFLSFFHSFLFFLLLTEQSIIYELLSIIYEVLAGLAFLSFFISLSLSFFLSFFLSFFSRNSPLSMKYWQDLPFFLSLFIYLFLFFLSFFFSRNSPLSMKYWQDLPFFLSFFLSFFLSFFLSFLSFLFISLFLSFFLPFFLSFFLFFFLSFFFSFFLSFFLSLGSNKHPIHYLSIYLSIYFSLFIIYLSIYLSIYLSIYLSILAYSLSIYLSIYLSIYLSILAYSLSIYLSIYLSIYLFHLFIIYLSIYLFQSVLIYLSIYLSIYLSIYLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D654</accession>
    <name>A0A812D654_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_46801</name>
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    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
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        <dbReference type="NCBI Taxonomy" id="158019"/>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="protein sequence ID" value="CAE1287869.1"/>
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    <dbReference type="Proteomes" id="UP000597762">
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            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1287869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="368" mass="41295" checksum="C8A6D5C7D97F65BC" modified="2021-09-29" version="1">MLLYLFWGICLSLILVIHQFASHYFSIWSSIPLSLLLFLAIHSYPSLCGQPSLSRYPSSCLSLLLIHLILSFFLVISPSISFTLCSHHSVSCSLFSFIHLSFSFELSIHPLFSFFLFSINHLFSSFSLSIHLPLSLCHCLSIHQPFFISPSLFLPFFISLSLFLVIHTSAYLSLILVIYPSASLFLLIHSPIFLSFLLFSKSSLSLSLVIYMSAFLSFSPSLFLLIHTSSSIHPLFSLFLFSINHLFLSGYPYIYFSLSLVIYMSVCLSLFLSLSLSLSYFSNPFICLSVSLSLSLSQLLLAITVCLSLSGHYLSVSLIIFVTSMCENLVLAHFPNDSQLRSSVFFFSFFLIRQATFGIICLVVSSGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D782</accession>
    <name>A0A812D782_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">SPHA_47333</name>
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    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
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        <name type="synonym">Sepia pharaonis</name>
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        <lineage>
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            <authorList>
                <person name="Li R."/>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="512" mass="62458" checksum="7686F647C8084CA6" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D817</accession>
    <name>A0A812D817_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">SPHA_46893</name>
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        <name type="scientific">Acanthosepion pharaonis</name>
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            <authorList>
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                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="CAE1288049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D817"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="466" mass="58175" checksum="950144F7D558EB26" modified="2021-09-29" version="1">MPERIYPFICRVFFFTSLFSLSLSLSLSLFSLSLLVSFFFFFFFSFSFIPSFFPLSSFLFFFFSSFFFFFFFFPSFLFFLFFFRILFFFLSFFVFSLSLSLSFFLSFFFFSFLKTFFFFFFLSLFIFFSFSFFPSLFLFLSFLFSFFLFFLFFFFFLFFFFFFFFFLFFLFFFFFFILSFFFFFLSFALSFSSFFLSLFFLLSFSLFSSFFLSLFLFLLSLFLFLLSFFRSLFYSFFLSFFFFFLSFFFFFLSLFLFLLSFFFLSFFFFFLFLFLFLLSFFLSFFFSFFFFFLSFSLSFSLSFSSFCLSLSLFSPFLCFLFSHCKFLFLFFFLFPYFSLLLYFFLFVIFFLSLFLSFFLHFFFPYFFFPLPMLLSFFLFRLSFLFSSCTLSLLSFFFSFSLPFFLVSFSFFLSLFFFLFFLRLSFILFHFLTLFFLSLFHYTIYNLPPPLSLSLFQYYYYFWLHTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D843</accession>
    <name>A0A812D843_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Helitron helicase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_48968</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
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            <taxon>Sepiina</taxon>
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            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002775">
        <property type="protein sequence ID" value="CAE1291891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D843"/>
    <dbReference type="OrthoDB" id="1728974at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786:SF74">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786">
        <property type="entry name" value="DNA BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helitron helicase-like" evidence="2">
        <location>
            <begin position="539"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1291891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="807" mass="90455" checksum="5C4A5075565EC750" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D9A6</accession>
    <name>A0A812D9A6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_51015</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003054">
        <property type="protein sequence ID" value="CAE1295625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D9A6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032470974" evidence="2">
        <location>
            <begin position="19"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="502"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1295625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="540" mass="57307" checksum="BBDC94EBA2CCFE60" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DAK9</accession>
    <name>A0A812DAK9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_50185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002933">
        <property type="protein sequence ID" value="CAE1294114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DAK9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="328"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="358"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="391"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="415"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1294114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="445" mass="53338" checksum="512CAEC6F45D9BAF" modified="2021-09-29" version="1">MYLPFPLSHYFYLSQSVLYLSIYLSISIYLFTIYIFFCIYVRMFFPLLFESIFLSFLSIYLSSVHILFIHSFLSIYLLSISICSYLSIYLSIYLYVCFFLLFYLNLSSFFLSYLSIYLNLYISIYLSIYLSIYLSIYYLSVHHIYIFYYLSVICTYVFLFLFESIFLFLLSYLSIYLNLFISIYLSIYSICSYLSIPSIYLSFIYLSIYLYVCFFLLLFESIFLFLSYPSIYLSIYLSIYLFTIYICFYYLSVYMYVCFFSSFYLNLSSFSLFPIYLFHLSIYLFIYLSQSVHIYLLSIYLSIYLSVHHIYMFLLSICIYVRMFSSFYLNLSSFPSFHLSIYLSIHLSIYYLSQSVHIHLSIHLSIIYLSILILFLIHLSIYLSIYLSQSVHIYLSIYLSIYSSIFYSICSHLSIYLIFYLSISFCSLSIIYLSSIIYLSISICP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DC53</accession>
    <name>A0A812DC53_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_51024</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003054">
        <property type="protein sequence ID" value="CAE1295629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DC53"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1295629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="205" mass="21626" checksum="9E8E1EA15F5DE27F" modified="2021-09-29" version="1">MHYFNFLFYSHIHSFLNLTLPFSSLAPHQISSSSSSLAPHLFLLLSCASPLPPPLLRLSSSSSSLAPLLFLLLSCASPLPPPLLRLSSSSSSCAPPPLAHPLLLRPSLLLLFAPLLFAPLSSTSPAHPSSRPPLLFAPPLLLRPSLLLLLPLPSSPLPPPPLAPPPLLFLHPTPSSSSTPPLPLSLSCSILLSSNPLSQIQPDSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DF41</accession>
    <name>A0A812DF41_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_54655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003572">
        <property type="protein sequence ID" value="CAE1301845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DF41"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1301845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="286" mass="34398" checksum="1DA593D964C93362" modified="2021-09-29" version="1">MNHNPDPASPSFTFLLRPLATFTTHVSRLFFFFFLRVLSFCTSLFGICIFCGTFVPSFYYYFAFPLLFNNFSFFSILLLTPFSRVHSFACTLFLFISLSFFLSFFLSFFLFHRILLPSCHIHQFVICLSFQMVPVRSPTAFSFFLSFFLRNFLFHFISFFVHSAFYFHGLFFLSRKFSFIIFLSLSINVLAFINIFFPISFHFTLFSFFSDRSSFLSFIIFLSYFSFIFFFCDVFNFHFQQQFSFIIFLSFLLYCSLLLKIHFHSFFSQYFLSFIMTFFHSFLDFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DFW8</accession>
    <name>A0A812DFW8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_52987</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003327">
        <property type="protein sequence ID" value="CAE1299021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DFW8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1299021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="250" mass="29467" checksum="BE5B9A1BD44B6797" modified="2021-09-29" version="1">MPAFIRCFFFFFSYATLTFVLSGLTSLGIYFSFFLFFFLSFFFSFFLYLFSFYLYLILLFSLSLFHFSLFFLSIFLSFFLSFFLSFFSMFHNWCLRLLNNFLYMTLSLFFSLSPIFSLAPLFFSLFISFLPTPFVYILYPLLSLYIYILSFPLSAYIISSLTLYAYFLFTSLSIYIGFLPLPLFLIYSFSQLSHIHFNRTRFFPPPSLSLSLSLRLCLFPLFLSFLSSSHLFSLIFCLSLPHISGGIEAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DGS2</accession>
    <name>A0A812DGS2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_52638</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003303">
        <property type="protein sequence ID" value="CAE1298537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DGS2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1298537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="167" mass="20158" checksum="BAEB935C4DDDAF9B" modified="2021-09-29" version="1">MLVLFSSVPNAHFLSFLNVPFSFFLSFFLSFFLSFFLSFFLSLPCYICCSVILYFYFFILLILYIINSLFFFPSFFFFLSFFLSFFLSFFLSFFLSFFAFVPCALLLSFFPFCLFPLFFLSFFLSFFLSYLVFFFLSFFLSSLFRFSHISFRVLSFFFSFFLSFLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DH83</accession>
    <name>A0A812DH83_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_56851</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003794">
        <property type="protein sequence ID" value="CAE1304090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DH83"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1304090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="174" mass="20717" checksum="BD86CEAFB4121A5C" modified="2021-09-29" version="1">MYFRLSLIYLSIYLSIYLSIYLSMIKTDLVSQPDSVGDQVIIYLSIYLSIYLSIYKYTSLHYSSIYLSIYLSIYLSYTVNIYLSIYLSIYSILFLSLSLSIIYRLLLIYLSIYLSIYLSIYLSIYLYSYLSIPVSSYLSIYLSIYLSIYLSIQFFFYFIRFLTNFLYCFSVLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DHQ9</accession>
    <name>A0A812DHQ9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_56995</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003813">
        <property type="protein sequence ID" value="CAE1304380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DHQ9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032772355" evidence="2">
        <location>
            <begin position="19"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1304380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="326" mass="37919" checksum="2A696461AAF90F14" modified="2021-09-29" version="1">MSFLLFLSFSFVRLLIDSFSLPDSNQSLTCTTRSVFHYLRHFSFFPFSFLSIHLYPSLSVSLSLSLCLNAFRAYLIFKIFLSLYVILSHTRSPYLPLSLSLSLSLYLSIYLSISHSIYMSNFFSYYFSFFCSPSFSLIFPTFFSKILSLSFLLSHFSLSFFLFSRSFSLLLSVLFFLSPSFSLIISLSILILFLSFLLFHSLSPLHFLLFFPSPSPFPLVVSFFLSFFLSFFLSFFLSPSFSFILSFFFPFFLSPFLSLIISLSFALLPSLSFPLLLPHSFFLLSLMFFNLFLHLTYYCFSLFQHALSIYLYHLTSQRANTCFHNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DHW1</accession>
    <name>A0A812DHW1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_55549</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003713">
        <property type="protein sequence ID" value="CAE1303426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DHW1"/>
    <dbReference type="OrthoDB" id="9635126at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="327"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="357"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="398"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="431"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="467"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="529"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="556"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1303426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="587" mass="68883" checksum="26B48314A18E2069" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DKX4</accession>
    <name>A0A812DKX4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_58280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003973">
        <property type="protein sequence ID" value="CAE1305910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DKX4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1305910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="282" mass="33604" checksum="BA810DCA5015AE35" modified="2021-09-29" version="1">MPGLIPQTRKISLSLSLSLYLSIYLSIYLSIYIYMYMYIYIYHSSLSIYLSIYLSFLLYLSLSLSLSLSLYIYIYHSSLSIYLSIYLFLIYISLFNIYLFMHMLIFMRTHTHIYQSVLYLSIYLSIYLSIHLSIYLSLFIIYLSIYLSQSANICLIFYIFILPCSCPLMFQFVQFFLTFPIYVSKLIDSFLNYFVLISNSPFIYQYSVIMKYRRTKISIYLSQPVHIYLSIYLSIYLSIYFDDCFILSFLICLSQTVRNYLSIYLSIYLSDCLSISVLFFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DLB6</accession>
    <name>A0A812DLB6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_53877</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003443">
        <property type="protein sequence ID" value="CAE1300473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DLB6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1300473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="197" mass="22932" checksum="5A98BB60399F3A08" modified="2021-09-29" version="1">MVRSTAFADIHTYFIALSSVFFPSFSFFFLSFFPLFFVFSISSFLFLSFFLSFFLSFFLSFNYLPSFFFHFLPSIIVFYLFSLFLFFLSFFLSFFPLFSVFFLSPPSFFFLSFFLSFFLSFFLSFFQLFTRQQETQVTSPALVTSLSVSLCLSFLLSHRTALSILAHSFFHALSKSLSLFVSLSILSRLSDLSHSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DLT7</accession>
    <name>A0A812DLT7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_54115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003485">
        <property type="protein sequence ID" value="CAE1300894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DLT7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="304"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1300894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="357" mass="43873" checksum="F59FE63C0033908E" modified="2021-09-29" version="1">MESYEFEVHIHLILTSITHSFHVYLFIYHLFFSYLSVILFICITYSFYIYHLFFLYLSITFYIYHLFFLYLSITYSFYIYLSITFYIYHLFFLYLSLILFISITCSFHVYVILFIFITYSFHIYLSLILFISIYHLFFLYLSITYSFHIYLSITYSFYIYLSITYSFHIYLSITYSFYIYLSLVLFISSYLSHILFISITYSFHIYLSIVYSFHSYHLFFSYPSHILFLSITYSIYIYLLFFLYLSLILFISITYSFYIYLAIYLSLILFISITYFFLYLSLIFISITYFHIYLIAYSFHSYDLFFISITYSFPIYLSIYHLFFSYLPTYLISSSRELHDWQQSTKYIDGAMGEKFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DN43</accession>
    <name>A0A812DN43_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_57000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003813">
        <property type="protein sequence ID" value="CAE1304368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DN43"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1304368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="262" mass="31882" checksum="1687CBC0DCF88251" modified="2021-09-29" version="1">MSFFLFMDFFFCYSSLLSYHFICFFFTFYSIISFFLSFFLSFYSFFLSLLTLLITFSFLLTFFFHSDAFLFSYLPFYFLFLWCFVSFIFAAIFCLLLTYFLSYRLFFVFFFCLLSFVMLLFSSFLLSYFSFLFIHSFILSWFIFISFNFKSFFLSFLLISLVTSLFFFISLLYFLSFFLSFFLFSFVTAFIFLLPLSDHSFFFVSSFFISLIPKYFFLFYVTSLSIFISLLFTSFCHSFSNSILLRLFMLFLFFSDEMNPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DPF5</accession>
    <name>A0A812DPF5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_60290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004187">
        <property type="protein sequence ID" value="CAE1308396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DPF5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1308396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="151" mass="18443" checksum="9A728065F5D3BCA0" modified="2021-09-29" version="1">MLKKEGTISLFSIFLSHFSFFLFTYFPFCFSQFFVFFFQFLSCLLFCFFLFLYSLHHFFLSSFTNPFSFFFTLNLKLSTFSVLFLSIFSLSSLTFSLHSSYSFILSLYFTPYFIHFFKLFFFHFFFHSFFKNHFLSLHPCIYLLLYKTNID</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DQS4</accession>
    <name>A0A812DQS4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_56793</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003794">
        <property type="protein sequence ID" value="CAE1304207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DQS4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="418"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1304207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="474" mass="53623" checksum="A129FEAD94E13F9F" modified="2021-09-29" version="1">MMEKIVKRTQIRKSRRHREANAICAENSKFYLTPFFFILYSFRFLCLFSFLCFLAPSFSSFLGLFFRIHLIYFNSPSLLSFLLLYHFTSHYLSLSFTSLIFVFLALSRSLSLSLSLSLSLLPQTHKRTYIHAHIYAKYHKYTYFFSINLITFSFLTTLFLPLSLVFIPPLPSLSPSLSPHLTSHISFSSFPTLYLGFSFLFNLPPIVTCFHLLSLLRLLLFFLLLLRLLLFFLLLLRLLLLFLLHRRRLLRHSSSSSSSFSSLLPFIFFFSSSSSSSFPSSSSFPHQPLPFHHHHHHLFFLFFSLPFFLSSPSLSSSPSPLLFLLFFFFSFSSSSSSSSSTSSLPSPLLLILSPSSSSSSSSSSSSSSSSSVVVVFSSSSFFSSSSSSHPPLSLHLPLFLIHPFLFSSTSLSFSPPLLFLLFPLLFVVVVFYFFSSFSHSSSSLSPSSSSPPPPLVLLILPPRLLLPYAILCIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DS20</accession>
    <name>A0A812DS20_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_59296</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004104">
        <property type="protein sequence ID" value="CAE1307167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DS20"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1307167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="381" mass="43408" checksum="4E84B6BDA212E182" modified="2021-09-29" version="1">MQRRSWCNGELNETRNQQSRFNFILTISIYLSIYLYIYASLFICVYLSIYLSIYLSNSSFHISLSLHIYLSIYLSIYLSIYLSIYLSLLLCLFISVYLSIYLSNSSFHIPLSLHLSIYLSIYLSIYLSIYLSIYLSISVFSYLSIYLSLRTKILLNPFLSNHSVEVRSHSRDPVAFAERYPQRVKNATVEISIDGLGLMTNPILRDPQIRSLSLNVLYRRPQNATVEHSIDGLGLMTNPILRDPQIRSLSQNVLHQRPQNAALEISIDDLVLKTSPILRTPQIQSLSPNVLHERPLNAAVELSIDGLALMTNPILRDPQMQSLSPNLLSQRPQNAAVELWIDTLSLFSCNCILPSVGITDLVRNLFDSTSYMTGNTVFLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DSQ4</accession>
    <name>A0A812DSQ4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_60016</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004155">
        <property type="protein sequence ID" value="CAE1308069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DSQ4"/>
    <dbReference type="OrthoDB" id="6129481at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="311"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="339"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="367"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="413"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1308069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="432" mass="52077" checksum="0951342947458DC9" modified="2021-09-29" version="1">MWTKNESNTMPDRTRHGSTTAARPIDTLQDGRDKWTTGAISTVNLLTQAKPHMTITQAYAPNSDHDDEEVEGFHESIEFIIADVHKKNTIIVQGDWNSKLVYCVLYSHIPSFFLFSFFRSFFLLSTFCSFVLSFFRSFFPSFVLFPFFPSFVLSFFLSFFRSFFPSFVRSFLLSFFRSFIPSFFPSFVRFSLLSFFLSFFRSLFPSFIRYFFLSSFCSFVLFFFSFFHSISFLSFFLFFFRSFFPSFFFFFLRSFFPSFFFFLSFFRFLFFFSFFLSFFFLFPSFILFFLSFFPSFFRFSFFFVRSFLLSFLLSFSFVFLSFFFLLSFVLSFFSFLSFFFFFFLLSFVISFFLSFFLSFFRSFFPSFFPSFLLSFLLSFFLSFFLSFFRSFLLSLLSLFAMIHILLSSFDKLCIYLSIYLSIYLSIYLSIDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DSS9</accession>
    <name>A0A812DSS9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_61692</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004384">
        <property type="protein sequence ID" value="CAE1310066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DSS9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1310066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="286" mass="32153" checksum="83837CB389583EC4" modified="2021-09-29" version="1">MFHSFQGYKYICQLLDERYQSIYLSSIYLSHLISLSLSLSIYLSMFLHMVFKYLSIYLSIYLSMTANVCSLLFHPRLFFLSVCLKIFICQFLNLSYTYSFYTMRVEIALSLSFSLTLSLFLSISFPLPPSLLSSSLFLSHPPSSSLFLSFLSLILSLLLSPSLFLSLNLSLLVSLSPHPSLSLSLTLSLSLSSPSLLLSLSLPLSHPLSFSTSLSLFLSPHPLSFFLFLSLSLSLSHLSLNLSIPLSLSPLFPLSFSLPYLFPHSISLSRSIYLSIYLSIYLSIYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DUU2</accession>
    <name>A0A812DUU2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_61211</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004310">
        <property type="protein sequence ID" value="CAE1309514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DUU2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1309514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="203" mass="24602" checksum="28DD8D7D1F27402A" modified="2021-09-29" version="1">MFFLRSSFIRFSFILTRFSFFFLSLSFIHLSFFLSSIFRSLCLHDNSFSLLYPFYLFFFFTFHFFLSFFLSFFLSFFLSFRLSFFLPFRLSFFFISKHLLLFQSIFSSPFLSLHPNFFSFLCFFVLTVPQFTSTRHYFFDSLRINPKRALDNNNNNRTSPPDATFHSLFSHLSQRFISLFIRRLLCLILPVIFHDIFPAFCYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DV68</accession>
    <name>A0A812DV68_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_61413</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004340">
        <property type="protein sequence ID" value="CAE1309743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DV68"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="286"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="321"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="350"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="414"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1309743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="437" mass="53076" checksum="6B975E7FF15E610F" modified="2021-09-29" version="1">MDAKEERLAREDVKRREDFSFYCSFLILFCLLFFTFSLLFRICTISSFYNNISLSFVLYQYFLHFFLSIFLSFCPCFIRSVILSLALLFSLFSFYINLSFVLITFYVNIFFLFSFVICQLFFLSFYANICFFRFMTIFLILYFYFFHFMSVFFLLWQHFLPFVFLSFFLSFFLSFFFLSFFLSAYFVRPFALYQSFLLPFCDSFFFLSSFLFFFISFVRFKLILLYFFLITILLFFFFFHFMVIMLSFILLFIHYMSIFLFSFYVNISFFRFMTIFFSFFHFFQSLFLSFILCQCFFHFIPIFSLFHFSFCLSFFCSFVRFYVNFSSFVLCYSIFLSFVLFTYFFFHSFFFFYIGPLCHAVLLLLFSSSSSTSSSSSSSSSSSSSSHYYYKNAIFIAFLFLPIFSFYLPFFISLSLSIIYLSISIYLSIYLSIYLSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DWK0</accession>
    <name>A0A812DWK0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_60422</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004203">
        <property type="protein sequence ID" value="CAE1308565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DWK0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1308565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="218" mass="25447" checksum="C02E41743D3BBF51" modified="2021-09-29" version="1">MLSIFPGCTFFFLLTVFLIVFSSLSLSLSLSLSLSLSLSLTYWLLFSFFHSFLNPLSPTLSLFYYSPCLFFLSDFFFYLLFIFFSYSNTFFLAHIFISLSLLLSPSLSLCLSNTLVFLPFLFLSFFLSFFLFLIIFLPLSLYIRILFVYSFALIISFILFSFFFLCCFPLSLCLTFSFFFNCINLFLFLIFFPTFLSLLFLSIFLSKILFPTILITSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DZ28</accession>
    <name>A0A812DZ28_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_64143</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004620">
        <property type="protein sequence ID" value="CAE1313028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DZ28"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="375"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="405"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1313028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="451" mass="54513" checksum="A447047BD8530AF8" modified="2021-09-29" version="1">MLHFVFLLLLFVPFSLPSGFSFSLRLLIFFFFLSLFFLYMDFIFSLQCFFVFSFFISFNFLCLYSIDLFFFLNFSFHFHFFFTGLCIIFLSFFLFSFFFQFFFLSLDLFLYSFLTSFLIFFKVLFFFIFFLYGNFLHRSFFCLFFFLSLRVFFSFLFSLLSYLSFTSLLYVHFFIAYLFTCISLLILHNFSFYHFFFFTLIFFFSFCFSLHRFLPLYFFSFFLSFFTDVFYGFLGSFFLSFTFVSSFKRKKCKDISFFTGFFLFSFVTCNLIFSFSTGFFFLLLQIFLSFVTNFSFFQVISFFAGLSLCSFFFTTFSLCFPFFISLLRYLALHYFVFGFSKKTSFFISFVFLPSFFFSLLLSFLPSFFHSFFPSFLSLIHILLIIFLFLNFLLLFLRLICFACSILSFSFLAFHLYILLFPAYILSLFEILRPRLSSLFVLPGSSFFLTQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E054</accession>
    <name>A0A812E054_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RPP40</fullName>
            <ecNumber evidence="1">3.1.26.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_63851</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.5" evidence="1"/>
    <dbReference type="EMBL" id="CAHIKZ030004588">
        <property type="protein sequence ID" value="CAE1312649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E054"/>
    <dbReference type="OrthoDB" id="63112at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030681">
        <property type="term" value="C:multimeric ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000171">
        <property type="term" value="F:ribonuclease MRP activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013893">
        <property type="entry name" value="RNase_P_Rpp40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15396">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15396:SF1">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08584">
        <property type="entry name" value="Ribonuc_P_40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1312649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="289" mass="33005" checksum="91184AAE1AF296D2" modified="2021-09-29" version="1">MAATMSNSFRSGKLIVDISNFADKNNKCNKVVLSHYFNFSVGIIIPGFQEIPKSLKKTLQDSMSVHFVKLVPLSLLVSPIFLDNFCKKGHLYMMSHGTKIDTEDCIVILPSGKLIMNLTKDTYERLGLEGKKSQFHSIRNDRYVVVINMLNPSFVPGKNYYERVKWSFTDRLNLCYNMLVSWIPHNCDISSSISAYFEMNDLLSVPVGLKCKTNTYTDLPFPVINSKEPNDSIESCDYEELFDWLGSISCDCINSDDPDGFLPLYKISDQIPFFFLNSLEVWIFSLKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E159</accession>
    <name>A0A812E159_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_66242</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004777">
        <property type="protein sequence ID" value="CAE1315298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E159"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="338"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="367"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="423"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1315298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="455" mass="54606" checksum="B52FCBB1988B67FA" modified="2021-09-29" version="1">MYIYFLSNIPSFLPSFLPSYYFHYLSIYLSIYLSIYHFFLSFFLSFFLSFFLSQSFHIYVYIDIYYLSIYLLYIYIYISYVYQFVSISISFYLSIYLSIYLLYIYIYIYIYMLISLYLSQSVYIYLSIYLSVCLSIYLSIYLSIYLTIYLCHSLFFISKGFIQTTVLHLGDCATTTCCILKDIYCNWRERALITFSSVSIYLSSCQSILFFFYLSLPSFLPSFLPSFLPSFLPYYFHYLSIYLSIYLSIYLSIYLCLLHPSRPSFLNYFSSSIYFHYLSIYLSIYLSIYLSISSCLPFFLPSFHIILIIYLSILSIYLSIYLSIYLSIYLSLSFYRHIFMFYLSIYLSIYLSIYLFLSFFLSFFLSYYFHYLSIYLSIYLSIYLSIYFFLTTYFHVLSIYLSIYLSIYLPSFLPSFLPSFLPFILFSLSIYLSIYLSIYLSIYLSSFTHNSLGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E177</accession>
    <name>A0A812E177_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_65995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004749">
        <property type="protein sequence ID" value="CAE1315029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E177"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="322"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="360"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1315029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="384" mass="44617" checksum="C4BD9BF869F16EC1" modified="2021-09-29" version="1">MDFPQSSVYGLPGRVEWRDHCVLSELFLYICASLLHLLPFSNVLFFPFISVLSFFLSLPSFSFLHPFTFPLLPSFTFLYTLFPFPFCLHFLSFLFCFPFSILPDLLLLSFLSPTFPYRFVLFLFPFWFLSFPFLPSFPFLFVLLSLFTLSSFPFPLCPPFLFLSVFLSLSSVLLSFPFPLCTTFPFLSVHLSFSFLTSFPFHFCPPFPFLSVLLYSSSQRSFPFPLSSFPFLFLSVLLSLYFLSSFAFPLCTPFLFLSVLLSFSSLYSFPFPLCTPFLSSLSSFPFPLCTPLLFLSVPLCFSSLCAFSFLQCSFPFPFCTPFPFLSFLFLSFPFHSFLFISSLSFFLFPFSPPSPYEFVLLSHFFFSLPFSYFLFIYFSRPRHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E372</accession>
    <name>A0A812E372_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PXDN</fullName>
            <ecNumber evidence="6">1.11.1.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SPHA_63505</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.7" evidence="6"/>
    <dbReference type="EMBL" id="CAHIKZ030004549">
        <property type="protein sequence ID" value="CAE1312256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E372"/>
    <dbReference type="OrthoDB" id="823504at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140825">
        <property type="term" value="F:lactoperoxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475:SF4">
        <property type="entry name" value="CHORION PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475">
        <property type="entry name" value="OXIDASE/PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00457">
        <property type="entry name" value="ANPEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="150"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="4">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR619791-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAE1312256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="447" mass="49266" checksum="F150670CBB818C7C" modified="2021-09-29" version="1">MMSLHHLFVREHNRLADILSAAHPDWTDEVVFQEARRLVIAEMQHVTYNEYMPVVLGPTLMETYNLNVLTQGYTTYIDNINPAIRNGFASAGIIYSHSGLRSVATIGDSQNPLSSLFYNSDVFYNGVDAPTLVFQGLTSDMAQSVDSFSFIYLSIYLSIYLSIYLSIAFSSLSIITIYFESVEDIDVWTGGVSEIPVEGGSVGPLLACIAGRQFQALKMGDRFWYENAGENQLSIDCLNAIRNVSMSRLICDNTNIQQIQGNAFIAASDAASSSTSLFSPVNSFYIAPSSPFNYIYPSSPFNYIAPSSPFNYFVPSAPFNYITPSSPFNYIASSSPFNYIASSSPFNYVAPSSPFNYFAPSASLNYIAPSSPFNYIAPSSPFNYIASSSPFNYIVPSSPFNYVAPSSPFNYFAPFSPLNIISSSSPFNYISSSSPFNLFTRMNRGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E3V3</accession>
    <name>A0A812E3V3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_67557</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004896">
        <property type="protein sequence ID" value="CAE1316928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E3V3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1316928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="214" mass="25448" checksum="FA27196E7085DA03" modified="2021-09-29" version="1">MRLDLYFYSCAAIGFFVSFLLFFFFHRIPFSFNSVLLPLFFLFLFSFISFHFFFVILIFSSSVSHFSFLFYTSLSFFDQHSCSFPLSLCIHKFLCFPLLFSFLSRLPFISLFFFIYSFRRLAITEMCVFLLFFFYSFFCVSLISLLFIRSLFFLFSSFVFHSFLFFMFYLLFYFHSSFLSLFALPYFSLSLSLSLSLSHSLSLSSCLYLAPGSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E788</accession>
    <name>A0A812E788_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_66929</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004832">
        <property type="protein sequence ID" value="CAE1316163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E788"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1316163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="170" mass="19583" checksum="A8C3E5F6A185B5B3" modified="2021-09-29" version="1">MFALIVLFIFCRLFLLFFYLVSLLLFFSFFLSFFLSSSSSSSSSSSSSSSTEFQRQLSSSSSVSTEFQRQLSSSSSPHPSSSSFSSSSSFSTFLYICCSFYSIFLLVFRLPLCIYPDLFFFHFIFLLFFPLFLTVFFILGVIRNIFPYTDYNPSIYYFVSIINPPTLILF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EAV0</accession>
    <name>A0A812EAV0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_69987</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005114">
        <property type="protein sequence ID" value="CAE1319659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EAV0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1319659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="314" mass="36931" checksum="F8DB7CDD381304C7" modified="2021-09-29" version="1">MFFLFSLSFVYAFSFPFPSLMHFFSFSHALFFSLSSSHTFFLFSLFLSHVFFFSLSSSHTFFLFSLFLSHVFSFLSLPLTRFFFFLSSSLTFFLFSLFLSHVFSFLSFSCIFLFSLTHYSFSLMHFSSLSLTHFSLFSLSHAFFFVLSLSRIFLCSLSLTHFSLFSLSHAFFFVLSLSRIFLCSLSLSHIFLRSLMHFSSLSHTFFFALSLFLSCIFLSSLSFSRLFFFSLFLAYFSYFFSLFLSLIFPILSLSIRHFFSHMQFLFSLSLMFFSFYSLSLSHTFSFPLSLTHFPFLSLSLMYFFSFLSLTSVFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EB56</accession>
    <name>A0A812EB56_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Casein kinase I isoform alpha</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">CK1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SPHA_70212</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Farmed</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="CAHIKZ030005136">
        <property type="protein sequence ID" value="CAE1319875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EB56"/>
    <dbReference type="OrthoDB" id="5800476at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14128">
        <property type="entry name" value="STKc_CK1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000120">
        <property type="entry name" value="Casein kinase I isoform alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000538">
        <property type="entry name" value="Putative Casein kinase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="20"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00071374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00082669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAE1319875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="323" mass="37753" checksum="21602C961F64C3D0" modified="2021-09-29" version="1">MDTSCDRSANRSEFLVGGKYRLVRKIGSGSFGDIYLGINITNGEEVAVKLESVKARHPQLLYESKLYKILQGGIGIPHARWYNQERDYNILVLDLLGPSLEDLFNFCSRRFTMKTVLMIADQMIGRVEYVHNKNFIHRDIKPDNFLMGIGRHCNRVFMIDFGLAKKYRDSRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRGSLPWQGLKAATKKQKYEKISEKKMSTCVEVLCKGFPAEFSMYLNYCRGLRFEEAPDYMYLRQLFRILFRTLNYQYDYTFDWTMLKQKATSNVQQQTVTQAAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ECC7</accession>
    <name>A0A812ECC7_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ataxin-2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SPHA_68277</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Farmed</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PAIP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004961">
        <property type="protein sequence ID" value="CAE1317766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ECC7"/>
    <dbReference type="OrthoDB" id="5985142at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000900">
        <property type="term" value="F:mRNA regulatory element binding translation repressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045947">
        <property type="term" value="P:negative regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040396">
        <property type="entry name" value="PAIP2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009818">
        <property type="entry name" value="PAM2_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13154:SF6">
        <property type="entry name" value="GEO05078P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13154">
        <property type="entry name" value="POLYADENYLATE-BINDING PROTEIN-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07145">
        <property type="entry name" value="PAM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="2" id="KW-0832">Ubl conjugation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAE1317766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="150" mass="17843" checksum="E1A5FA6C27EA1E92" modified="2021-09-29" version="1">MKTLFLCSRIPFQRDSQTDKPTLTRSHSNLIFTTKVLKMKYPKATKETPAENSEHDFSEYMWMAEEGVENFDRQVENELWEEMFIEACFEEMLAEEEQWFYPEQNSELADMLQGIHLSEEFTEERIKNSLLNPNAPEFIPRWCKNTSVTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EF44</accession>
    <name>A0A812EF44_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_74063</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005407">
        <property type="protein sequence ID" value="CAE1324338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EF44"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1324338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="157" mass="17566" checksum="51A3C5F6975F9558" modified="2021-09-29" version="1">MASFFNFYFFNIQNPLLILSSFWSCGPSLTFIVFFYSTFCSLSITLASNFSFLPLFTVISPPVSSLILTNASVTSTLSITATSAITTSVSILFNSILPIFSTTLISKNICITSHISIYLSIYLSIYLSIYLSIYLSVFTLSQTRRRLSLSFLQILSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EHW1</accession>
    <name>A0A812EHW1_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SPHA_72664</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005336">
        <property type="protein sequence ID" value="CAE1322701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EHW1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="257"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="89"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAE1322701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="294" mass="34175" checksum="05BF94A14D365B06" modified="2021-09-29" version="1">MTDRVNLVYVAHNVIGLLLGWCSECFDLSIYLSIYLSIYLSIYLSIYSHPSIVYSLYLSIYLSIYLSIYLSIYLSLSVFICVCLSLCLSNSLSLFNSIAVSLYIRVCISIYLSIYLSIYLSICVFLLSYFFLSVMYVSLSVCLSLDICFYLSIYLFICVSLNLSIYLSIYLSIYLSIYLSIYRYIDIYLSVCLSLIYLIIFTATGIHLFIVVLTFFLFIFSLSHYFLSFFFSFFLSIRQNNHFVQKCLLIHASVHMLSPFVSLAFLAFFLSFFLSFFLSFFLSFFLFVNISHDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EIN0</accession>
    <name>A0A812EIN0_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SPHA_73009</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005354">
        <property type="protein sequence ID" value="CAE1323144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EIN0"/>
    <dbReference type="OrthoDB" id="690068at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19683">
        <property type="entry name" value="bHLH_SOHLH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039583">
        <property type="entry name" value="TCFL5/SOLH1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15402:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR LIKE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15402">
        <property type="entry name" value="TRANSCRIPTION FACTOR-LIKE 5 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3" id="KW-0221">Differentiation</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0744">Spermatogenesis</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="10">
        <location>
            <begin position="454"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="85"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAE1323144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="523" mass="57875" checksum="49CB5588F741CC33" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EKH5</accession>
    <name>A0A812EKH5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_77314</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005514">
        <property type="protein sequence ID" value="CAE1327909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EKH5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1327909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="198" mass="22797" checksum="8D814C242CFDCDFE" modified="2021-09-29" version="1">MSSFTITLVFPLLILLHSIAFFDIIKLFFLLLTIVLFLLLSRLLPSFSFFLDYCPLSPSFETIALFLLLLRLLLFSFSRDHSTLSPSLETIVLFLLLSTLFLPFPFFKKNRSLFISLMDNEADTSLDFFLFLQNSFSFSLFFLKRVKKDLSDDVKVGLSVSIYLSIYLSNVVCAHLSIYLFNVVCAHLSIYLSIYLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EM83</accession>
    <name>A0A812EM83_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_75006</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005446">
        <property type="protein sequence ID" value="CAE1325367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EM83"/>
    <dbReference type="OrthoDB" id="6150645at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF20">
        <property type="entry name" value="REVERSE TRANSCRIPTASE-LIKE PROTEIN WITH RNA-DIRECTED DNA POLYMERASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1325367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="215" mass="23971" checksum="D3F4F0179A212FEF" modified="2021-09-29" version="1">MRHDGFPSKLLNLIKAYYAQTRTRVRCYGEESDSFVVRTGVRQGCLLSPILFSYIIAWILENSMVGLEGVRVGHDCNITDFDYVDDVAILSESYVEVQHALDEVSRMVKMVGMKINASKTKIFSANFSLSDRVAVTLDGEAVEEVESFKYLGANFTATGQAKDEIPTQTHPKASFSFSLSLSLYLSIYLSISLSIYIYEGVPGTLSLSLSLWPLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ENT8</accession>
    <name>A0A812ENT8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_79414</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005566">
        <property type="protein sequence ID" value="CAE1330060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ENT8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="445"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="488"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="511"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="539"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="563"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1330060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="584" mass="67632" checksum="842B3E826EC994E4" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EQG6</accession>
    <name>A0A812EQG6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_75120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005451">
        <property type="protein sequence ID" value="CAE1325473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EQG6"/>
    <dbReference type="OrthoDB" id="6161790at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1325473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="153" mass="18305" checksum="3FB033AF239ADC6A" modified="2021-09-29" version="1">MPLIFNDIKWKNRNLYANYFGEHASDLFTEERVKHSNSYLSIYLSIYLSIYIYIYIYIYIRLFFIPIYLSIYITSSFYTYLSIYLSNFVCSYLSIYLSIYLSIYLSIYLSICSYLSPSVHIYLSIYLPLSVYLSMSVHIYLSSSVHIYLSIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ERJ2</accession>
    <name>A0A812ERJ2_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GAIN-B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SPHA_80991</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005617">
        <property type="protein sequence ID" value="CAE1331865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ERJ2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057244">
        <property type="entry name" value="GAIN_B"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50221">
        <property type="entry name" value="GAIN_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="GAIN-B" evidence="6">
        <location>
            <begin position="88"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAE1331865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="203" mass="21398" checksum="175042B86FA3BF7D" modified="2021-09-29" version="1">MFLLSVSHQIINTTDQGRGKRCNFSLPLSLPLPRISLFLSSSISLAPSLYLLLFFPLSLPSLSAPLLPPSLPTLPLSLTHSPHCLSLPTVSLPPSLYLPLSPSLPLTPSLPPSHLPSLSISLSPSLLLSPLPPSLSRSPLSLSISLSLPSHSFSIPPPPSISLSPLSLSISLSLPSLPLTPSLSLPLYLSFSLSPPSLSLCNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ERU9</accession>
    <name>A0A812ERU9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_78470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005540">
        <property type="protein sequence ID" value="CAE1328822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ERU9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1328822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="244" mass="27165" checksum="CC44B906912CF68F" modified="2021-09-29" version="1">MKLGRCCLGITVHSCFFFSTFFLSLSLSLSLSIYLSIYLSISILSLFLTHSFSLYLSIYLYPISPSPSLSPSLSLSISILSLILSFTLFIYLSIYLFISSLTHSFTVSLYLSISSLSLSLSIYLYPLSHSLFHSLSIYLSPLSTSLSLSIYLYPLSLSLSLSIYLSISSLYLSLSIYLSLSSLTLSFTLSLSIYLSISSLYLSLSIYLSIYLYPLSHSLFHSLSLSIYILFLLSLFLSLSVVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ES03</accession>
    <name>A0A812ES03_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">VPS37</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SPHA_77659</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Farmed</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Late endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS37 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005520">
        <property type="protein sequence ID" value="CAE1328089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ES03"/>
    <dbReference type="OrthoDB" id="10004364at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043162">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009851">
        <property type="entry name" value="Mod_r"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13678:SF27">
        <property type="entry name" value="LD45836P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13678">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07200">
        <property type="entry name" value="Mod_r"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51314">
        <property type="entry name" value="VPS37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="VPS37 C-terminal" evidence="9">
        <location>
            <begin position="173"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAE1328089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="301" mass="34088" checksum="7FDACE4729ADFF01" modified="2021-09-29" version="1">MKGLSKFRLLFFKDGLFVISAFISPLILLVYVFLRLSSPMSYMNYGPLYGGMCENPPALPPRNPNVPTPPYGSPAMSGNIIPGQAPRLVINESEAVALLQHLDRDELRALLENENKLDELVQDLMQVKNIQQDREMMLASNKSLAEYNLEIRPRFEELKQTIAKNYAEISQLKTKLAEDIGNLDVILNNQSLETILALIQADAATTEEESEKLADDFLDKKSETEQFLEEYIPKRTEAHLKRVKTEKMSDLIQNRNLSTPPMSDLHHSSFHWKDSSSGHCPYPSANSAGSFMRMPDPSHYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ETI0</accession>
    <name>A0A812ETI0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_79170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005560">
        <property type="protein sequence ID" value="CAE1329767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ETI0"/>
    <dbReference type="OrthoDB" id="10003277at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057435">
        <property type="entry name" value="Lips"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37686">
        <property type="entry name" value="LD36006P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37686:SF1">
        <property type="entry name" value="LD36006P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25228">
        <property type="entry name" value="Lips"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="462"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="473"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="497"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1329767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="526" mass="61270" checksum="2AD8AD7A47AB6926" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EW80</accession>
    <name>A0A812EW80_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Potassium channel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SPHA_79825</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005579">
        <property type="protein sequence ID" value="CAE1330531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EW80"/>
    <dbReference type="OrthoDB" id="297496at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF334">
        <property type="entry name" value="FI03418P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="211"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="10">
        <location>
            <begin position="190"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="100"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAE1330531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="298" mass="34454" checksum="DE992B81F7D1068F" modified="2021-09-29" version="1">MAGTFKFIYYHICYRLYLRWQQLKRFIVAKRRKQHLRMRQARLALEELIEKGNEMWRSTEMLLMKGGEEENGGEELLSTYKANKELQRKEIARDRIGARRLKSQRTKRKSKHLDANSRKSVSCSGKSIPVACENDVERDSDIENEDFKQSSQIASVANPARISSDRRLSNKEIRKRIPQVRVPISVSLLVIAAYVFLGAVLFSLWEKNWDYLISSYFCFVTLSTIGFGDFVPGSDVESWSSAEKQAICTLYLLFGMAMIAMCFNLMQQEVILKFTDLGRRMGLIEEKQVSSLDEPCTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812F2Q3</accession>
    <name>A0A812F2Q3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PDCD6IP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_81569</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005638">
        <property type="protein sequence ID" value="CAE1332537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="entry name" value="PCD6 INTERACTING PROTEIN-RELATED"/>
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        <property type="entry name" value="PROGRAMMED CELL DEATH 6-INTERACTING PROTEIN"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
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            <end position="738"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="822"/>
            <end position="835"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        <source>
            <dbReference type="PROSITE" id="PS51180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1332537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="853" mass="94701" checksum="BF0D237C78BBEE80" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AJH3</accession>
    <name>A0A812AJH3_ACAPH</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">SPHA_231</name>
    </gene>
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        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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            <taxon>Metazoa</taxon>
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            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000002">
        <property type="protein sequence ID" value="CAE1138187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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            <dbReference type="EMBL" id="CAE1138187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Acanthosepion pharaonis</name>
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            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
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                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <dbReference type="EC" id="2.4.1.267" evidence="3"/>
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        <property type="protein sequence ID" value="CAE1142624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ALB4"/>
    <dbReference type="Proteomes" id="UP000597762">
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0042281">
        <property type="term" value="F:dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="match status" value="2"/>
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    <proteinExistence type="predicted"/>
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            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="Heme-copper oxidase subunit III family profile" evidence="2">
        <location>
            <begin position="418"/>
            <end position="717"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
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        <source>
            <dbReference type="PROSITE" id="PS50253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1142624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="851" mass="107552" checksum="7441186D80305754" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AMZ5</accession>
    <name>A0A812AMZ5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
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        <lineage>
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            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
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            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
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    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <dbReference type="AlphaFoldDB" id="A0A812AMZ5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
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    </feature>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="265"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="313"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="367"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="409"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1147215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="426" mass="49311" checksum="088ABEEF9160EC19" modified="2021-09-29" version="1">MLTMENVSRLSGNQFTFTLPRVFPSTPPHCIHRFASLFSTSILSLSLPLSWFSSRSTTTIFPLYAFLTSPSLLTAFILPFSLLIDSSLAIFSIFLTPTYVLPLPLPHIIILSFFLSFSYFLHHILSNEHFSSISIYLSIYLSIYLSIYLNIFTSISGYSHLSIYLSIYLSIYLSISTYSHLSQAILIYLSIYLSIYLSQHIHIYLRLFSSIYLSISTYLSISGYSHPSIYLSIYLNIFTSISGYSHLSIYLSIYLSIYLSIYLNIFTSISGYSHLSIYLSIYLNIFTSISGYSHLSIYLSIYLSIYLSQHIHIYLRLFSSIYLSIYLSIYLSIYLNIFTSISGYSYLSIYLSIYLSISTYSHLSQAILIYLSIYLSIYLSIIFVLSSIITNKWHYRLTWDEMMKKKNSIIYLSIYLSIYLSIYLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AQF2</accession>
    <name>A0A812AQF2_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cadherin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SPHA_3311</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000098">
        <property type="protein sequence ID" value="CAE1152107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AQF2"/>
    <dbReference type="OrthoDB" id="6252479at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24026">
        <property type="entry name" value="FAT ATYPICAL CADHERIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24026:SF126">
        <property type="entry name" value="PROTOCADHERIN FAT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Cadherin" evidence="4">
        <location>
            <begin position="41"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAE1152107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="168" mass="19104" checksum="F227302947A43127" modified="2021-09-29" version="1">MYFYLSIYLSIYPFISICLQVANHTLNVTVLGVNDMSPTFNNSIYQFYMKEDRPNGTLLGKVIATDKDKNPSESIKYSILGSRDFNIDASSGVIRTARTFKISEPTSFTFVTVTVIVEAFNQVNPKEWNSINITITFKDINNNVPRFQKSQYKTHIFENSTVGSTILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AQZ6</accession>
    <name>A0A812AQZ6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_3490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000105">
        <property type="protein sequence ID" value="CAE1152598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AQZ6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1152598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="200" mass="24101" checksum="A285A6D74775481C" modified="2021-09-29" version="1">MRNIFHPAHPPSPFRGISAVHRLIMIGELVGRTNGSSYGTRIILLFISFWKHKIFFVFLRYVVFRFLFVFIHFSSFFDIYCQLIKIIFNYFLSIDFPLSFPLFFSFFISFLSFCFLSFICLFLFFFILFFPFLSFFPFFTFLSFHLFVSFFSFLFSFFLSSRFFLSFFLSFLFSYLSIYLSIYLSIYLSIYLCGPVYLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AR84</accession>
    <name>A0A812AR84_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AREL1</fullName>
            <ecNumber evidence="2">2.3.2.26</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_4091</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="2"/>
    <dbReference type="EMBL" id="CAHIKZ030000126">
        <property type="protein sequence ID" value="CAE1153964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AR84"/>
    <dbReference type="OrthoDB" id="6057829at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058738">
        <property type="entry name" value="PH-like_AREL1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25916">
        <property type="entry name" value="AREL1_PH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Apoptosis-resistant E3 ubiquitin protein ligase 1 PH-like" evidence="1">
        <location>
            <begin position="103"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1153964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="197" mass="22541" checksum="C20B3CD3E74366D8" modified="2021-09-29" version="1">MNYSSTVVCTVGTSHPLTIETRDMFGNLTPYKADQQNYFKIRVRETGSNARHVPATQIFYDPASRRLTMHIRMEKEGSFQATVTYGDVKLKNGEFNILVLSCDDTARVKKNLAKRSHDIWYEARLISCNHEHLEKPKKVYVYMSPKTPVTCPLLVNFFSLPILITTLNHGCQEQCFLLWDNYCSYLSVIKFSAGLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AS76</accession>
    <name>A0A812AS76_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_3674</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000111">
        <property type="protein sequence ID" value="CAE1153015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AS76"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1153015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="271" mass="32392" checksum="2B660E184E60D57B" modified="2021-09-29" version="1">MLSLSLSLSLSLSLSLIMNTLINIAKEAHFSFFLSFCLSFSSLLHFFIQFSSIFSFFFSFLPFSSAPSSHLFTFNSYIFPSSFTLTDHFISFCFLPSFYFYILKFLLSFSFFFYIPIIFVCFNFSLKPFLLYFSFPSLNFLILHFRLYLPSFSRQHITNNSLKDTRLGFLSIFSRFSPSFHSFSLYYYISLLIHILLFLQLILYVLYISCLFFLILFLILYFLYFLSYFSFLPYFFFIFCIFFFILSYPISFTDISASFLLMYTPLHFSYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ATI6</accession>
    <name>A0A812ATI6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_4887</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000160">
        <property type="protein sequence ID" value="CAE1156723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ATI6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1156723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="273" mass="31149" checksum="67C71969D2113B05" modified="2021-09-29" version="1">MCSFIHPRKKLKMWSTLKSSASDTQTPFHFSFSCKKITLLSKLNLICSKKVTSCGVSRGRKLSDDREIEAARTWSVTRLLNTLSPPFHFPQLPLAQSTPRPPPDGFVSDPKNLLSNSTPPSINPSRVSMLPEYLSIYLAIELAIYLSKSVPYLSIYLSIYLSIYLSIYLSKSVPYLSIYLIPISIYLSIYLSIYLSTHIYLSIYLSIYLSIYLSKSDPHLSIYLSIYLSIYLSIYLSKSVPYLSIYLSLFHIYLSIYLSIYLSIYLSILLPSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ATT1</accession>
    <name>A0A812ATT1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_6733</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000220">
        <property type="protein sequence ID" value="CAE1161167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ATT1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1161167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="208" mass="24513" checksum="E0EF157F257618A1" modified="2021-09-29" version="1">MNWMGKHHAFIMTGSFDLIARVYLSIYLSIYLSIYLSLSVHKIFSSHSRISIYLSIYLFSLAHIRQSDEGLTAVHDGVRREVAVLFHKRLVPREVVLVEARERVVDATHETRRRCQQLQYIYLSILTCFYLSIYLSIYLSIYLSIYLSISDYYFLNIYLTLIHMISQSSSLFIYICFNARAHIHVYTHTRTPHLSIYLSIYLSIYLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AUQ4</accession>
    <name>A0A812AUQ4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_5572</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000183">
        <property type="protein sequence ID" value="CAE1158335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AUQ4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1158335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="238" mass="28433" checksum="E19D6FCDD694A735" modified="2021-09-29" version="1">MPSVLLVLFSRPLIISPFFYLCIVSPFFSLCIVILFFRLLIISPFFRLLIISPFFFVPSFFLSFFLSSISLKQTISTRELFFLSFFLSFFLSFFLSFFLSFFYFTEADDKYPRTSVFLDFSFSFFLSFFLSFFLSFFLSFFLSSISLKQTIKADDKYAIASFSFFLSFFLSFSFCLSFFLSFYAISLSFDFSFLYFFFIHHSFFLPFFSFFSFLFSLNFSFFRGFLSYTVYARVSCDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AV34</accession>
    <name>A0A812AV34_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CCDC77</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_4719</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000153">
        <property type="protein sequence ID" value="CAE1156307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AV34"/>
    <dbReference type="OrthoDB" id="191169at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037696">
        <property type="entry name" value="CCDC77"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22091">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 77"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22091:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 77"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="57"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1156307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="201" mass="23761" checksum="22F5232113EDC2C8" modified="2021-09-29" version="1">MLQGPLSSIGVILQMPPLIFSRPFSRSFLLFTLAVTFLIPNLNSPFSCLPNFLAERSNKMSKRLQMMNTRYQELEKRRHFEVEGFKNDIKNLRSRLKDVERQLYKVTLGLAEEMDEKRPDDLDLRILRNVRLSTGRSQKIMGELKNLKSKLNLFWLRIFFRLEFLKQFFLLFHFSISSGFIPLTLSTCQQYFTHFHSLSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AVH6</accession>
    <name>A0A812AVH6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">IDUA</fullName>
            <ecNumber evidence="7">3.2.1.76</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SPHA_5132</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Farmed</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.76" evidence="7"/>
    <dbReference type="EMBL" id="CAHIKZ030000170">
        <property type="protein sequence ID" value="CAE1157298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AVH6"/>
    <dbReference type="OrthoDB" id="15153at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003940">
        <property type="term" value="F:L-iduronidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1500">
        <property type="entry name" value="Glycosyl hydrolase domain, family 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049165">
        <property type="entry name" value="GH39_as"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049167">
        <property type="entry name" value="GH39_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049166">
        <property type="entry name" value="GH39_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000514">
        <property type="entry name" value="Glyco_hydro_39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051923">
        <property type="entry name" value="Glycosyl_Hydrolase_39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12631">
        <property type="entry name" value="ALPHA-L-IDURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12631:SF8">
        <property type="entry name" value="ALPHA-L-IDURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01229">
        <property type="entry name" value="Glyco_hydro_39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21200">
        <property type="entry name" value="Glyco_hydro_39_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00745">
        <property type="entry name" value="GLHYDRLASE39"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01027">
        <property type="entry name" value="GLYCOSYL_HYDROL_F39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolases family 39 N-terminal catalytic" evidence="5">
        <location>
            <begin position="2"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-iduronidase C-terminal" evidence="6">
        <location>
            <begin position="527"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600514-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF21200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAE1157298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="622" mass="71818" checksum="F208DEBC2645786D" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AVL3</accession>
    <name>A0A812AVL3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_7737</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
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            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">Farmed</strain>
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    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <source>
            <dbReference type="EMBL" id="CAE1163588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="773" mass="92238" checksum="9105A82A5EBD1845" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="4">Dynein heavy chain</fullName>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </evidence>
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        <source>
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</entry>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
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        </submittedName>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">Farmed</strain>
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    </evidence>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000395">
        <property type="protein sequence ID" value="CAE1172007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B7J7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1172007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="263" mass="30548" checksum="B0E5F8FED61D785D" modified="2021-09-29" version="1">MLGTLIPLPSSLYIIPSFSHSFFSNASLFSFFSCNSLRTRYISIFFLFLFFPFFLLPYCNSEPKYIEIDVLPVNKYQGQTRWLTRQQIIRQKEITLSLSLSLSLSLSTASFVVALSNTSPCNNPTTSVRCFVPPFVKVFSVRLFVVYTTGIYSNKHHLIYLSIYLSIYLSIYLSIAVCCYHSLFLSIYLSIYLSEYVAIYHSLFLSIYLSIYLSIYLSQYVHINLSQYVAIYHTMFKSIYLSIYLSIYLSIYLSIYHSIFIAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B9R4</accession>
    <name>A0A812B9R4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_11825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000393">
        <property type="protein sequence ID" value="CAE1171898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B9R4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1171898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="214" mass="23995" checksum="13864EEB1AA627DA" modified="2021-09-29" version="1">MFLISCPVSFPPSLPHSFSNSLSLTHTHTFACFLILPLFLPSSFSFPLLSSMFLFFLFLSLSLSLSLSHTHLRMFLISFVSFPLSLPYSFLFLILSLSLTHTHVLHLRMFLILLPLFSLHTPSFVFFSCPVSFSSFSSFLSLILSRTHTPSHVLISCPVSFPLSLPYSFSLSLSLTHTPSHVFNLLPCFFSSFSSSFSLSLSLSLSHTHTFACF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BA39</accession>
    <name>A0A812BA39_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_12891</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000432">
        <property type="protein sequence ID" value="CAE1174040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BA39"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1174040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="197" mass="22934" checksum="1A0DD55556F9F673" modified="2021-09-29" version="1">MSVCAYLSIYLSIYLSILACSYLCQSVHIYLSISTIQVYLVVWNKAGVFLQKLQGVWQSGIETTGMCLSLNLQFGLFGSFSQCLARLYLWTFVQTRYTYHSFIYLSIYLSIYLSIFSFSLSSYQPIFPSRFLRERKIEIFFIFLSLYLSIYLSIYLSIYLPFLSLSASILFFLVLLSIYLSIYLSIYLSIPFLPFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BB86</accession>
    <name>A0A812BB86_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_14199</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000483">
        <property type="protein sequence ID" value="CAE1176573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BB86"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34723:SF7">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34723">
        <property type="entry name" value="PROTEIN CBG17025"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1176573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="277" mass="30661" checksum="9D9A1A7A61000420" modified="2021-09-29" version="1">MYIGIRLCLRDPFISSGSLYLFGILLSLRHPFSSSGTVYLFGICLSLRDSFISSGSVYLFVIHLSLQDPYICSGSFYLFGICLSLWDPCISSGSVFLFGKLLSLRDPLLPSFLPSFLPSFLPSFLPPSSFLPSFLPSVLSSLIHFFLLPSFLPPSFLPRSFVPSFLPSFLPSFLPPLFSFLPSILPSFLPSFLPSFLPSFLPSFLSSLLPSFVPPSFLPRSFPPFLPSFLPSSFVPSFLPFLPSFLPPSFVPSFLPSSLLCSFLPSFPSFLPSFLPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BBW8</accession>
    <name>A0A812BBW8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_13875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000468">
        <property type="protein sequence ID" value="CAE1175894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BBW8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1175894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="220" mass="26092" checksum="22741B6C3122CFC9" modified="2021-09-29" version="1">MKIAFGDINLRLTSFFSFLSFFFVFLITFYLSHSLIFYLFYLAISVIVKVSVHPFLFSFFLSFIFLSLLFFISYLFSLYSSLFLSFYFCLCISIYYYLFMLAYLYTQRPFHTISISISLFPSASLSIYLFSFSSFFSLFLFLSALFSYNLHLLISLLLYFISLKFSASLFHLLPYSFFLSWVLPLLYLFISLFLILIILDSIFNSQSILLFFFFLTTLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BEZ6</accession>
    <name>A0A812BEZ6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_15471</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000537">
        <property type="protein sequence ID" value="CAE1178909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BEZ6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="266"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="295"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="326"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1178909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="369" mass="44345" checksum="08DBC3A58A589F36" modified="2021-09-29" version="1">MTQTNLSIYLSIYLSIYLSIYLSIKHKLLMTQTNLSIYLSIYLSIYLLMTQPDTLLCVFHSFLRQSFLSFFLSFFFISFFLSFFKLFFLFLSLLPQSLLSFFLSFFLSFFLSFFTSINQFFFLFFFLLSFFLSFFLISINSFILSFFLSFFLFFFLSFFLTTINQFFLSFILSSFNQFFLSFSPQSINSFFLSFFLSCLNQFFLSFLTQSIHSFFLSFFLSFLPQSIHSFILSFFLSFLPQSIYSFILSFFLSFFLSYLNQFIHSFFLSFFLSFFLSFFLFLTSINLFIQSISPFFFLFLFFLSFFLSFLPQSILSFFLSFCFNHFPFYSALIVFCFTYCPFFILHFLSLSFPFLSFSLGFLFCILLYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BF24</accession>
    <name>A0A812BF24_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_15614</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000545">
        <property type="protein sequence ID" value="CAE1225094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BF24"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1225094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="171" mass="19890" checksum="E2B996BC87A63EC9" modified="2021-09-29" version="1">MIRDSSKQKISGVWGLFILFASVKLSLSLFFLSIYLSIYLSIYLSQSLLFINLSHSFSIYLSIYLSIYLSIYLSIYPSQSFYSLSILVCLLSFSLSLFSLSLYIYIYLSQSAYSLLIYLSLFISIYLSITFSSYRPVFRCLSTQNYMYPYINIIIIIRGKPVHFKQGTFIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BFW1</accession>
    <name>A0A812BFW1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_15997</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000558">
        <property type="protein sequence ID" value="CAE1226373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BFW1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1226373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="282" mass="31132" checksum="47896E5098D300E4" modified="2021-09-29" version="1">MCNVDTGLSFSVQSCPRRVGLWRNQCAISFTVGLSLAKSMCNLYQGVSVVGEINVRSRPMPVCLWQNLLCNLVHGVSVFGEINVQSRPLRVCPWQNHCAISTNACLSLVKSMCNLDQCPSVIGEINVQSRPLPLCLWRNQCAISTTACLSLAKSMCNVDHCLSVIGEINVQSRPLHVCLWRNRCAISSTAGLSLAKSMCNLDQCLSVCDEINVRSQPRLFCLWRNQCAVSTTACLSWQNQCEITNNASLSLMKSMCNFVHGGPVFGEINVQSRPLTLSLWRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BI28</accession>
    <name>A0A812BI28_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SPHA_16454</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000579">
        <property type="protein sequence ID" value="CAE1227615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BI28"/>
    <dbReference type="OrthoDB" id="3229771at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF73">
        <property type="entry name" value="PROTEIN PDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="176"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="HTH CENPB-type" evidence="3">
        <location>
            <begin position="6"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAE1227615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="249" mass="28721" checksum="399F5EA041C681CE" modified="2021-09-29" version="1">MNRNTNRKRKRQSVHKDVNEALTQWFTQACAHGATVTDHVIRQKASQLAVNLEVDFEPSNGWLMRWKQANNVSFKKFHGESTSADHGSANEWVTNVSPQLFRGYDPKDVWKCDETGIFYKDMPSGSLRFAGDEQSNGTKVPKDRLTMLQFTNMDGSEKQAVVVDGSELERVTHGGIYFFIYLSIYLSIYLSIYLSHIIHIYLSLLHIHIYLSIYLSIYLSIYLSIYLTTYPYLSIYLSIYLTTNPYLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BIE4</accession>
    <name>A0A812BIE4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SPHA_17206</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000611">
        <property type="protein sequence ID" value="CAE1229256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BIE4"/>
    <dbReference type="OrthoDB" id="196547at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032613966" evidence="3">
        <location>
            <begin position="21"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAE1229256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="446" mass="50120" checksum="AE8FFF017B802CDE" modified="2021-09-29" version="1">MFFLSFFLLFLNILISLSLSLSLSLSLSPPPPLLLIRLALFMVLLPHSLIHNLTLNLLRNDDPVIYSILIFCFLSPPQGVHLEDSSSGSRGWTENDLEYFIKQLTNPQLYTNKTTSTSSSWSTSSHHQQVTTHTTSTFHSADSLSTDVHEKCHIGSPSNLRSRIVAPYDSQLGSDGCLCHEKTKKSKSRTFIKTSKEHKTRSSNYEDSVEISVDSVLDEGFSSSNRPHSCQNVVYTTSTATSNITSCTGSGYCAHFADSCSDDPDSSDSPHQQVSKRDKCADGCKKEHKRHFFHRMIPRPLRRSHSCGTAKDLATTVKSKTTEIELSDKVSQSKSSSIRKTSSFDARTLYLPDDLDGTSSSKPKSRNLAWNVKRKLHFLRRHHTDSSLPERFPKVNMVNAAKWGKSFDALIRDKDLHFSYSLHFLHIHQCNFFFSLPPTTETSPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BK06</accession>
    <name>A0A812BK06_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_19053</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000690">
        <property type="protein sequence ID" value="CAE1233691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BK06"/>
    <dbReference type="OrthoDB" id="5982845at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF11">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="181"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1233691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="299" mass="33675" checksum="A901C1423A0A7053" modified="2021-09-29" version="1">MTVIYRPGHDNPADYLSRHPIHLPPSDREQKVSEEYINYILSTSTPKPMTIEEVATETAKDKTLTAAIQALLTNKWYGIDDDVDKATFQTLHANRAELSLAHNDSIVLKGRRIVLPKTLQSRAAQIAHTRHQGIVKSTALLQEKVWFKNMQALVEENIRNCHTCQISTHKPAREPLQMSPLPAAPWTEVSADFGHLQNGKYLLVVTDEYSRYVVIDILDSISTTSVIPRLDKIFVKFGVPVSLNTDNGPPFNSSDFKDYASLTGFKHRKITPLWPQANAEMECFMRTIKKSIKAALIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BKF8</accession>
    <name>A0A812BKF8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_22056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000813">
        <property type="protein sequence ID" value="CAE1239932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BKF8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1239932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="352" mass="42186" checksum="730811B5D9207BAF" modified="2021-09-29" version="1">MFFCRSCLSVCLSVSLSLSLSLSLYLSIYLSITHAYSLIYLSIYLSIYLSIYLSIYLSIYLSIYLSLFLSLYISITIFLSRFQSIYLPIYNGLSRRIRHCLWVIISHFLDFSFTFSHFPIFSCKCSLLYFGFHNDLLFPPYEVFSYILVTRLSFLAFIRFVLVESNFRFLFSFIFHSSLPLYLSLCNFFFFQVLLSFVFIYLFLFFPFSSLFTFFLSFFNLISFAFSFFIINSSFFLSFFLSFLIQFLFSYISYSQPLFLSFLIVLFSYISHTRPFKTPYLKIAHSFFIVFFLSFFLSFLIRFLFFYDSFSFSFRFVFLSLVFFPTFARLFHPVQTYPHLFGMNSLREEIKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BKZ2</accession>
    <name>A0A812BKZ2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">C-mannosyltransferase DPY19L2P1,Probable C-mannosyltransferase DPY19L1,Putative C-mannosyltransferase DPY19L2P2,C-mannosyltransferase dpy-19,Probable C-mannosyltransferase DPY19L2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SPHA_18615</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dpy-19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000670">
        <property type="protein sequence ID" value="CAE1232570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BKZ2"/>
    <dbReference type="OrthoDB" id="6019623at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018732">
        <property type="entry name" value="Dpy-19/Dpy-19-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31488:SF1">
        <property type="entry name" value="C-MANNOSYLTRANSFERASE DPY19L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31488">
        <property type="entry name" value="DPY-19-LIKE 1, LIKE (H. SAPIENS)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10034">
        <property type="entry name" value="Dpy19"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="206"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="251"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="320"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="344"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="373"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="446"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="488"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="516"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="552"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="613"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="639"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="680"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="727"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="762"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="788"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="821"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="846"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="886"/>
            <end position="904"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAE1232570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1108" mass="126234" checksum="B9841910DFABFCC6" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BLR8</accession>
    <name>A0A812BLR8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_19024</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000688">
        <property type="protein sequence ID" value="CAE1233629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BLR8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1233629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="234" mass="28545" checksum="0CB77D534F25CEDF" modified="2021-09-29" version="1">MFFLFFPSFYFSFLFVSISIFLFPSFFFDSFLFLFSSSLWLLIFVFFFYLFIICSIFQPIILSFYQPIHFSFFLSFIQPMYYLFISFLPTCLLCRFFLSFDQPIQFSFFFLSFNLSALLVFFLFLTNLFFLSFFLSFNLLSFNLSALLVFFFLLTNLYNFLFFFLSFVCFVGFFFFLLTNLFCFVVFFLLTNLYNFLSFFLSFNLSALLVFFFLTNLYNFFFFFICLLLVFSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BNK3</accession>
    <name>A0A812BNK3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sperm-associated antigen 17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_19949</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000726">
        <property type="protein sequence ID" value="CAE1235868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10257153at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990716">
        <property type="term" value="C:axonemal central apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904158">
        <property type="term" value="P:axonemal central apparatus assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003351">
        <property type="term" value="P:epithelial cilium movement involved in extracellular fluid movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026173">
        <property type="entry name" value="SPAG17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21963">
        <property type="entry name" value="PF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21963:SF1">
        <property type="entry name" value="SPERM-ASSOCIATED ANTIGEN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14874">
        <property type="entry name" value="PapD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="530"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1281"/>
            <end position="1349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1521"/>
            <end position="1558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1293"/>
            <end position="1302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1303"/>
            <end position="1314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1526"/>
            <end position="1540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1235868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1558" mass="176403" checksum="A0EC1484C2A4E5FA" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BP44</accession>
    <name>A0A812BP44_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CNBP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SPHA_20967</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000768">
        <property type="protein sequence ID" value="CAE1237793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BP44"/>
    <dbReference type="OrthoDB" id="3863715at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="208"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="380"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="418"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="444"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="469"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="496"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="520"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="115"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAE1237793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="548" mass="64215" checksum="0A6F91FEE290DC02" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BVA6</accession>
    <name>A0A812BVA6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_22396</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000828">
        <property type="protein sequence ID" value="CAE1240567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BVA6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1240567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="201" mass="23482" checksum="E2295739182058B1" modified="2021-09-29" version="1">MFPFLFTQFRQLTFPFTPAATFPFTQFRQRFPFTQFRQLTHRDFGSSFPFTSLLTFPFSSFGLRPLSLSTFPFIQKTFPFTQFRRLTFPFHSFALPHRSLSLGFKLTDSFVPLSLYVSQFPFPLQFSSLSGLAYVPFYVPFSSFLQFRQPFPFTQFPFLSFGSLRSLSSSSLSAVYGFVFPFTQFRQLRSLYSVLAAYVPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BWK2</accession>
    <name>A0A812BWK2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_24019</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000891">
        <property type="protein sequence ID" value="CAE1243852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BWK2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032702127" evidence="2">
        <location>
            <begin position="20"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1243852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="233" mass="27077" checksum="7318272C0DC1F2D6" modified="2021-09-29" version="1">MLSLSLSLSLSLSLSLSLAYKHTEREVLSFPPPLYTLFFSISLPSVIRFVYPFFSNLSFSIALTPPLLLLNYYFHYFHLLFSSLSLRFFLSFPLTLSFHPLFVAFIFSSASTITFSCLLSLFYILSFFLFLRFTLFRFFCFHALLCLAYFNSFFLFFLSFFLSFFLSFFSNMMYLFPFPSPSFILSPFLLFSFPYFSNPFSPFPSTVHSYSCSLSSISLSFSTPLNSFSHHSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C0W6</accession>
    <name>A0A812C0W6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_27756</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001087">
        <property type="protein sequence ID" value="CAE1251972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C0W6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="325"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="392"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="439"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1251972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="466" mass="54466" checksum="3C9674F3C0361AD2" modified="2021-09-29" version="1">MSIYLSIYFLYLCHPSIYLSISMYVSIYLSIYLLFTSSITLSMSVCLIYLSIYHLFTYVCMSLSLSIISIYLSIYSPFLYLCLYVFYLSVCIYLSIHPHPLSFLSMSMSLSLSIYLSIYSPSSFTLSMSMFFISVFYLSSILSFTLSMTVCLYLCLSIYLSIHLILYIIYDCMSLSLSIYLSIYLSIHLILYIIYVCMSLSLYLSIYLSIYLFTSSFTLSMSVCLYLCLSIYLSIYVSIYLSIYSPILYPIYSVCPHPLSHYLCLYVFISVYLSIYLFSSFIIYCMSLSLSIYLFYSPILAVHYLCISLSHYLSISIYSPHPVTIYVFMSLSLSIIYLSIYSSIHLILYIIYVCMSLSLLSSISILCHYLCLYFFISVYSSIYLSIYSPHPLHYLCLYMSIHLSFYLFYPLHYLCLYVFSKSIYVHIYLSIYLSIPHSFTYMSASLCIYLFMFYLSKYVHIMYLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C2M7</accession>
    <name>A0A812C2M7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_27214</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001046">
        <property type="protein sequence ID" value="CAE1250611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C2M7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1250611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="192" mass="22047" checksum="92CA0DC195E2D78F" modified="2021-09-29" version="1">MREISHYKYQTSSENIIIILPTLYLSLSVCVSVCLSLSLSLSLSHTHTHTHTHTHTHTHTLSIYLSIYLSIYLSICLSVSLSSLNIRTFSSPHKRTFSSPYERTFSSPYERTFSSPYERTFSSPHELLPPHMNVFLPTRTFSSPHERAFSFPHERTVSSPLELFPPDTNFLFPPHKLFPPPPHELSPPDRIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C382</accession>
    <name>A0A812C382_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_31655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001304">
        <property type="protein sequence ID" value="CAE1259330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C382"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="41"/>
            <end position="63"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="97"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1259330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="235" mass="27364" checksum="A914A72B868BFF90" modified="2021-09-29" version="1">MNIVFYFSVDFYRFFFLLSLQPHHFLHSPPSSSLLLSLHHASFSLLFHSSFLFNISASSFLLLTLQPHPFPPPPLFLYPPTILFFLFNINSSYFFLISLQPRHFLHSPPSSSLLLSLHHASSLFLPTSFSSFCLTSSPPIYSSFLFNRASSHSSSCSSSLKPLLFPSPVFFFSFFFVLFNIAPPFLLASSSLELSSLFLHPFLFLFFFFFFFFFFFFNIPFSFLFFNLFLFSFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C3T9</accession>
    <name>A0A812C3T9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_31950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001324">
        <property type="protein sequence ID" value="CAE1259938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C3T9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1259938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="294" mass="35305" checksum="E89857ED039B6C16" modified="2021-09-29" version="1">MWLSHKPTYLSIYLSIYLSIYLSVCLSVYLSIYLSISPSLSLSLYIYIYVCFVSSFFLLSLIFIFFQLDFHRSFCLLYCLFFLLDINSLLFFLLSSIFFSFLRHVYISPLFFLVSLLFFFFLSPFFCFLSYFPSDLFVSTSLSFFPSFFLFYAFISFFLSLFFVLSLSPFLSFFFVLGFPLSFFLSFFLSFFLSFFLWDTYLPTTYLDWILLLSSNVIFLWFVVLFLSFFLSFFLSFFLYLFPSFFLLCFTEFQRYTSLVSRSFLLLCFGFFTLSFFLSFFLSFFGTQMTQLHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C419</accession>
    <name>A0A812C419_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_30927</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001250">
        <property type="protein sequence ID" value="CAE1257765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C419"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1257765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="848" mass="99048" checksum="D3506117E03B6D1F" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C489</accession>
    <name>A0A812C489_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Supervillin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SPHA_26838</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001026">
        <property type="protein sequence ID" value="CAE1249857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032914913" description="Supervillin" evidence="3">
        <location>
            <begin position="23"/>
            <end position="1629"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="693"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1171"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1336"/>
            <end position="1359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1383"/>
            <end position="1405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1494"/>
            <end position="1559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1604"/>
            <end position="1629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="693"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="742"/>
            <end position="753"/>
        </location>
    </feature>
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        <location>
            <begin position="760"/>
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            <begin position="773"/>
            <end position="785"/>
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        <location>
            <begin position="848"/>
            <end position="860"/>
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        <location>
            <begin position="917"/>
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        <location>
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            <end position="985"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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            <end position="1023"/>
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        <location>
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        <location>
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            <end position="1354"/>
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        <location>
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        <location>
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            <end position="1506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <end position="1529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1604"/>
            <end position="1614"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAE1249857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1629" mass="176741" checksum="6E30888ED48654BE" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
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    <name>A0A812C8Q2_ACAPH</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">Farmed</strain>
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    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="entry name" value="TESMIN_TSO1-LIKE CXC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
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            <end position="43"/>
        </location>
    </feature>
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        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1259085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="703" mass="79285" checksum="6D87059D9ECDC1B8" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <source>
            <strain evidence="2">Farmed</strain>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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    <name>A0A812CGF6_ACAPH</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Acanthosepion pharaonis</name>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
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    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CI83"/>
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        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
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        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
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        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1264260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="546" mass="65644" checksum="D1BBC429AAC4A4A8" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CJ56</accession>
    <name>A0A812CJ56_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_35779</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001555">
        <property type="protein sequence ID" value="CAE1267840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CJ56"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1267840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="367" mass="42980" checksum="3348B697997D0DDC" modified="2021-09-29" version="1">MRISVTLFLSFFSSYFLLSFFLSFFLSFFCFLFVFLSFSFFFLSFFLSFFLSFVLFDLKQSLLFFFLFFSVIFSSNLSFFLPCSLFVFLLFFYIVSFFLSSLLFFFLAFFFVIFSSYLSFFLSFFLSFFLSSFSTTDRSVSVYIALFLFFTDGRYFSVHPRLSRSFCLSVSLYLSLIRSILLDHPLWIFSALSLSLAIYLIYSSFSVSLFLSLSLSLSQSVHLSHFSLYRSHYHNQSILSLSLSLYIYIYIYIYILVCLDLYLSILVFNIFYVFISIYLAIYLSISRSLSRNLTLSFTLSVHLSLSQCQFVHVSLSFFPSHTHSIWLSTSIYSDVSDANLIEAICRGHHHFESISSDISKETKTKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CKK9</accession>
    <name>A0A812CKK9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_36571</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001602">
        <property type="protein sequence ID" value="CAE1269411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CKK9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1269411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="216" mass="25574" checksum="FC01B558514EAC28" modified="2021-09-29" version="1">MTFHKNNNIFSLSVCLCVYLCSIITIYLSISVHFLSFFLSIYLSISFGSFSLYLASYHGLFISIYLFHSVHFKSSDLSISVCLYLCIYLSIYLSIYLSICRYISRFVHIYLSIYLSIYISIYLSICLSLFIYLSLFISMYQSIYLYNYLSVCSYLAIQLSVRLFISIYLSIFIFFLSFYLSISFRSFSRYLSQFVHIYLSIYLSIYLSIYLSEYLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CL53</accession>
    <name>A0A812CL53_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_41090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001966">
        <property type="protein sequence ID" value="CAE1278164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CL53"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1278164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="157" mass="18020" checksum="013A68315DA3C79C" modified="2021-09-29" version="1">MRQILFSRNISAAFIVYLCLCLFVSLSLSLFTSSVCSLSIFVALLFYLSIYLSIYLSIYLSIYLSPQSLSVFIYLSIYLSIYLSIYLSIYLSIFSSPALSPSLSVCSYLSISVLLIFRLSIYFRIFTLAFSGYTHIYLSIYLSIYLSIYLTSVNREY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CLG6</accession>
    <name>A0A812CLG6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_41305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001979">
        <property type="protein sequence ID" value="CAE1278412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CLG6"/>
    <dbReference type="OrthoDB" id="8744624at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40240">
        <property type="entry name" value="PLEXUS, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40240:SF1">
        <property type="entry name" value="PLEXUS, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="556"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="261"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="286"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="556"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1278412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="874" mass="97221" checksum="E950B66B1951C200" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CLV5</accession>
    <name>A0A812CLV5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_37760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001691">
        <property type="protein sequence ID" value="CAE1272568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CLV5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="312"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="340"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="363"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1272568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="381" mass="45580" checksum="A65D743A38E35B25" modified="2021-09-29" version="1">MGWEKQMGMEWTGNFLFFLFLFHPLFFHFIIVLFFKFVFNLKLSSSFFPLFSFILILLRNIPSYLKPFSFFLLFPLLSLIPVFFLLLSFIRSFIPSFFYSLFPSFLPFISSIIPSFIYSNLFPSFIPSFFHPFLPLLIISFLLSFIHSFLYFLPVFLHSFIHSFFHSFLRSFLHSFIPSYFYSFILSFLLSFISSFHLLSDKFLIKSSSLFFLLSYIPYIFPSSSPDFPFLPTLFLFLFFPSFSVFFLTISSFISLLYLFLSLRCLLFLPTCSLSFPFYRLLFFFFFFLNSSLSPSLSFLLFSFYFCPLIPSFPPLFIFSFFLLFFPVLFFIISIDFSSNLKVFFLSLSLSFLLYPFFFLQSLAHHVSLYLFLCLFFFWFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CQS8</accession>
    <name>A0A812CQS8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_38364</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001736">
        <property type="protein sequence ID" value="CAE1273662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CQS8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="307"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="336"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="365"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="399"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="429"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1273662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="467" mass="57861" checksum="82E0C4FCDFBC777A" modified="2021-09-29" version="1">MFFFIRYISSLYFLSLIFAFLNSKCVFKISAFLLFSFSLYFVSRFPFFPLVTVFSKFLLCIFLSRSLFQQFFLPFFFISILSFVISFAFCLSLFFRLLSLLFLIIPFIFSSSFFLSSSLSFFLSFFLSFFLSFFLSSSRKYIYHFIDNRHGIYLSIYLSIYLSIYLSIYNLHMYACMYVFYGWMDEYIYLSIYLSIYLSIYLSIFLSFFLSIYLSIYLSIPPSSYVCMYVLFLLLFLYYFFFFLLHYFLCSLLDLIFFFLFQSFLFFLFHYFLFFNLELLFFFLFQSFLFFLLYYFLFLFLHYSPCFLLELIFFFLLHYFFFFLLHYFLFFLLHYFLFFLLDLIFFSLFQSFFLLHYLLFLLFHYFLFFLILYFLFFLLDLIFFFLFQSFFFFLLHYFLFLHLHYFLFFLLHYFLFFLLDLILFLPSSIFPFLPSLLFLFLSSLSFLFLPSSSFPSFIRILFSLYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CQV1</accession>
    <name>A0A812CQV1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ObgE</fullName>
            <ecNumber evidence="6">3.6.5.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SPHA_38396</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Farmed</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="6"/>
    <dbReference type="EMBL" id="CAHIKZ030001741">
        <property type="protein sequence ID" value="CAE1273700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CQV1"/>
    <dbReference type="OrthoDB" id="347018at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01898">
        <property type="entry name" value="Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.210.12:FF:000001">
        <property type="entry name" value="GTPase Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.210.12">
        <property type="entry name" value="GTP1/OBG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006169">
        <property type="entry name" value="GTP1_OBG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036726">
        <property type="entry name" value="GTP1_OBG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045086">
        <property type="entry name" value="OBG_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702">
        <property type="entry name" value="DEVELOPMENTALLY REGULATED GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702:SF31">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01018">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82051">
        <property type="entry name" value="Obg GTP-binding protein N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51883">
        <property type="entry name" value="OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Obg" evidence="5">
        <location>
            <begin position="71"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="OBG-type G" evidence="4">
        <location>
            <begin position="255"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAE1273700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="384" mass="42954" checksum="6FD7FDDE7E54AC91" modified="2021-09-29" version="1">MIDAILEIAHVEIFILFKRMFSRRFLCLAFEVKTIIRRTFCDFKPDFSFGDLDRPRVVKSHKPRSQSYADRNFVDFKEVQVIAGKGGNGCLSFLQLPQTEWAGPDGGDGGNGGHIIFEASRNVKSLGHLKSIIRGADGNNGRNKNCHGKNAKHTIVKVPLGSVVRNSEKKILSNLKRDNHYFLAARGGAGGKGNRFFLTNEERAPTTVEEGALGQNFHLSVELQTLAHVGLIGFPNVGKSTLLRAISRARPKVAVADIPGLIEGAHQNRGLGFSFLRHIERCSCLLYVIDLSGHKCWTQLTALKAELEQYQKGLSKRPHAIVANKIDLPWAKKNLEHLKNEVNLPIFAISAKHRVNMDPLLSQIRLLYDNNVELEKDLDEEEFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CRC7</accession>
    <name>A0A812CRC7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SPHA_38647</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001767">
        <property type="protein sequence ID" value="CAE1274140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CRC7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005283">
        <property type="term" value="F:amino acid:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001463">
        <property type="entry name" value="Na/Ala_symport"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00175">
        <property type="entry name" value="NAALASMPORT"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="286"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="344"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAE1274140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="384" mass="45983" checksum="248AF37D9BD63DD9" modified="2021-09-29" version="1">MSFPQKEISSLSLSLSSSSSSSSSSSFFVITIVNFFLLVYHVFLVLHYILLTYITISFFTIFFAIFIFFSFYISFFLLTFIIIIIIVFLRCLLRLRIFFLHYFIIRLFYLIVLLHHSYYYYYLPSTFFFFFFFFFIIIIIIIIIIIVHLLIFFLATFFFLISFFLLLLLLSFFAISPPSSSLLTFSSPPTCLFSPHYNYYYYYHYYCFVVVVFLHRFLLDYVHLFRLHLLFLLTIIINTIIIIILLSRLLLVYLRLLFLRLLFFSLLLLLLDVVVVIVVSFFDIFFLIALSCLFLFFLTIFFLLVVQFVIIELRTMIIISSFGFMTAAIFVVILYCFFRFSSAFGKYFLFFFFFLPSISDLLEPFHYLHRWKVAINFDALKGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CSV7</accession>
    <name>A0A812CSV7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_42823</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002112">
        <property type="protein sequence ID" value="CAE1281354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CSV7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1281354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="153" mass="18880" checksum="5D5FCB8F676E5769" modified="2021-09-29" version="1">MKGLRSCRGNRPFFFFFFFFFSSSSSSSSSSFLLLLLFLLLSSFSNNDDLLKQDYWYFSSFFIFLPGMFFFFFFFLFFFFFFSFFIIFIFFFFCTFFPFSNFLFFFFFFLRFFHFLSFRVLLLFRSSVTVFFSLILPSFSYFTQFFLSFILSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CT20</accession>
    <name>A0A812CT20_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BCL11B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_40514</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001913">
        <property type="protein sequence ID" value="CAE1277210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CT20"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1277210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="177" mass="20314" checksum="4D6505F2E6E6A957" modified="2021-09-29" version="1">MLFSSFLHLSSFLFLALLLLPSSFPSIVVAVFISIFFISPGLIIIIIIIIIIIIIIFFFFFVSFLFYLYSFPPSSLPFPHISFTTTTTTTTTTTTTTIFFFFLFYQYFSPPSFLPFPHISFTTTTTTTIFFFFSHAFLHLLPSSAASPLMRLFNPFQPANPLYFPSLPRHNDSLSHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CTD9</accession>
    <name>A0A812CTD9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_43082</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002138">
        <property type="protein sequence ID" value="CAE1281839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CTD9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1281839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="184" mass="21258" checksum="92D447167730BD16" modified="2021-09-29" version="1">MARFYSSLLRPVFSFTDQFPPIAINESVCLSIYIPFFFCSYYLSIYLSIYLFICSFLINNIHFFLFISIYYIFIYLSNPISVSLFLTLSFSFYLSIYLSIYLSIYLYLSIFLLLSLSLSLYRSISLFLSFLLSPSIYLIIPSSLFVSLYQSLFSPLSLCISLSIDLSISLFLSFLISLSLSICS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CVU1</accession>
    <name>A0A812CVU1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_41888</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002024">
        <property type="protein sequence ID" value="CAE1279693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CVU1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134:SF22">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134">
        <property type="entry name" value="OS08G0543275 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1279693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="324" mass="37921" checksum="9BDD0A95F3207493" modified="2021-09-29" version="1">MLFISVYLTIYSSVCLSIYLSQSVHVFYLMYSYLSTYLSQSIHIYISDICSYLSIYLSLFISIYLSIFLSLFVFIYLSNCLLISIYLSVCIYLYPILFISIYLILFIFIYLSISVYSYLCICSYISIDLSILVCSYLSIYLSIYLSIYISIYLSISVCSYLSISVCLFVSIYLSIYLSIYLSIYLSIYLSQSVRICLSLSVCSYLSIYLSIYLSIYLSIYLYIYLSIYLSLFVSVYLCLSVRIYLSIYLSIYLSVHLSIYLYLAWNKFTFFPPVNQFFILSFFLHTSVSPRDKELNEVHSPGKFWFCFLLLLLYLTVIAFTVNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CX35</accession>
    <name>A0A812CX35_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">T-complex protein 1 subunit eta</fullName>
            <shortName evidence="12">TCP-1-eta</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 12">CCT-eta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SPHA_43468</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Farmed</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Heterooligomeric complex that forms two stacked rings.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002185">
        <property type="protein sequence ID" value="CAE1282462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CX35"/>
    <dbReference type="OrthoDB" id="1935484at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03340">
        <property type="entry name" value="TCP1_eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000017">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.260.10:FF:000022">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cpn60_TCP1"/>
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        <source>
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    <sequence length="540" mass="59017" checksum="6EC93BBBB1BBBF1B" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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    <name>A0A812D014_ACAPH</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">SPHA_45006</name>
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    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
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</entry>
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</entry>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="362"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="427"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="462"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="494"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="527"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="560"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="7">
        <location>
            <begin position="257"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAE1290447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="588" mass="74147" checksum="F8BD2B1DB7AC981B" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D8F2</accession>
    <name>A0A812D8F2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_48170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002655">
        <property type="protein sequence ID" value="CAE1290108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D8F2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1290108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="284" mass="33176" checksum="007C599DF6E67FFE" modified="2021-09-29" version="1">MYVKSSSSSSSSSSFSSSSSFMLLVYLTATPSSCCHNPTSLFLSLFLSLFLSLSLSLFLSLSLSLSKAGRGESLTLNSWPHLSIYLSIYLSMFYLFSICIYYFSLSISFGSYLSIYLSIYIYIYIYIYIYIYIYISLFDIYLNRFISIYLSLFLSLFYMYLLLSDMYFIRFISIYLSIHLSIFLSIYLSIYLYIYIYIYIYHFSISISIGSYLSITFKYLSQTVPIYLSIYLSIYLSLYLSIYLSITFRYLSQSVHIYLSMYHFSISISVGSYLSIYLSIYLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D8H8</accession>
    <name>A0A812D8H8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_50666</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002999">
        <property type="protein sequence ID" value="CAE1294890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D8H8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1294890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="441" mass="46224" checksum="7B3AF4402B0302D4" modified="2021-09-29" version="1">MSSLSAPHVPLSLLYTPHHVLSLSLSLSPCPHMVHHVLSLSLSMPPYGASCPLSLSLSMPPYGASCPLSPCPHMVHHVLSLHAPIWCIMSSPCPHMGHHVPLSMPPYGASCPSLSMPPHGIMSSLSIMSSCPLSMPPYGASCPLSPCPTWCIMSSLSMPPHMVHHVSLSMPPYGASCPLSLHAPHGASCPPWASSSLHAPTWCIMSSLSMPPYGASCPLSLHAPIWCIMSLSLSMPPYGASCPLSLHAPIWCIMSSLSMLPPMVHHVSLSMPPHGASMPSMPPHGASCPSLSMPPCMVHHVHASLSMPPHGASCPCPLHHVLSLSMPPHGASCPLSPCPHMVHHVLSPSPCPLSPPIWCIMSSLSPCPHMVHHVPSLHAPHLSLSLHAPHGASAPLCPMSASCALCLCAPRGASCPLCLCAPPCSLSPCPRWSTVPSLHAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D9I6</accession>
    <name>A0A812D9I6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_51871</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003174">
        <property type="protein sequence ID" value="CAE1297166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D9I6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1297166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="222" mass="25692" checksum="DE8637CF58E0E1A2" modified="2021-09-29" version="1">MRAASIFSIFHVSIRRMFFSSLFIHLNIHSIAHLLNYSSAPIFRFLSCFLTFSSFIICLSVRVSSNLFNLSKKKLFLILSLSSILFFDIVSVLISFLNYFIIYSYSAYIHVFIFLSTFEHSLKCSFSPLYHSNAFSQYKSTTKMTLYISIGLFYCLHFPFFIQFLSLPAYLTILIYHSFTYDFFLSFCLSACLSACLSVCFPLSLSLSLHYAFLLHLHSSII</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DDJ0</accession>
    <name>A0A812DDJ0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_51415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003109">
        <property type="protein sequence ID" value="CAE1296380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DDJ0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1296380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="312" mass="34274" checksum="90C96326E850AB20" modified="2021-09-29" version="1">MCHSPFFILKKKTKNKKKNLSLPCFSFPPLYLPLPSSIASLSSPHLSLSLSLSLSLSLSIYLSIYLSLARRMCLFFIRIKNGAAPNTLSLSLFLYLSISPSLPLSIYLSLPLSLSIYLSIYLSLSLSIYLSIYLSIYLSLSLSIYLSIYLSIYLSISPLSLSLYLSISLSLSLSLSIYLSYLSLYLSIYLSIYPSLSLSLSGGCFKLKYKLPFNNSASPVILFRLTCYPLPPHLLSSSPHLLPSSASPAILFASPATLFHLTCDSLLPHLLSSSASPATSSASPATVFRLTCYLIPPHLLSRLTCYLLPPHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DFV1</accession>
    <name>A0A812DFV1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_52079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003209">
        <property type="protein sequence ID" value="CAE1297577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DFV1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1297577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="331" mass="37640" checksum="3C21C06C35DAE0C7" modified="2021-09-29" version="1">MPVPPEPPPRRRPAQPVPRGNRSSSNCARHQFAPCHFRAPISRLLYAFNIDSGSRARHKRCGRASPKARAFFRRIINSKAGVIDLHRAGRHRDRPLPPVTCPISRDGRRPDRLGPWGKSAARRTRSPPIAREQPTSTWRSSSPPAGSGRVAARSDRPVARTVWQGPWYGRLPADWSMVRSPRSWRSAAPMASFDPALYQQLLAQRKMTDAQVRTDLQRTLFTQQLTVRPSVPRRWRARWRCLYASLLLESGRRGRLHPDPSGQCRQRTERCGYPDLLQPQRPALYPARASRRALCAGHAVGDRGSVRADRRRDRSLLSDQRRVTPRPRSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DIF9</accession>
    <name>A0A812DIF9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">COMMD4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_54766</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003595">
        <property type="protein sequence ID" value="CAE1302071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DIF9"/>
    <dbReference type="OrthoDB" id="284322at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017920">
        <property type="entry name" value="COMM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047155">
        <property type="entry name" value="COMMD4/6/7/8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16231:SF4">
        <property type="entry name" value="COMM DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16231">
        <property type="entry name" value="COMM DOMAIN-CONTAINING PROTEIN 4-8 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07258">
        <property type="entry name" value="COMM_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21672">
        <property type="entry name" value="COMM_HN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51269">
        <property type="entry name" value="COMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="COMM" evidence="1">
        <location>
            <begin position="130"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1302071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="201" mass="22682" checksum="A2577CA762BBF608" modified="2021-09-29" version="1">MKFRFCGDLDCPDWVLAEINVLSKLTSVKMRLLCSQVIQNILGSKIDYEKVHKLTADAKFDVGDIKASIVALTFIITSAAKHDVDSDTLSNEMQQLGLPKEHSVPLCKLYGDNFIKCQDQLRKQTLRLSYFDSVKWRVDYVISSSSLKNVTEPCVKICFKVRENDSGTPQSVAFTLSAEKFRVFLNELKQADSVMDTLNAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DK84</accession>
    <name>A0A812DK84_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_57552</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003885">
        <property type="protein sequence ID" value="CAE1305056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DK84"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1305056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="266" mass="30270" checksum="69839FEFD1211B8C" modified="2021-09-29" version="1">MFSFLLSFFFLNFVISALQSNICLVTLLRFLSFYIIRLTFDIVTFFSFSFLFTYVPTNFLPTDVTLYRSSLSLLRSAAPSSISLENFSSVLLSFFTLQISTLARHITAYSYLSIYLSIYLSIYLSISACSYLSLSLYLTFAYLSLSLSLYLSIKVCSHLSIYPKLIISLSLCLANLSIYLSIYLSIYLSKTLYIYRTRREMSRAAAAIINCLHRSYNVFRRRKKETSIFAAEEDCLPTATTITAVAQYNHILPCGHDRLQCGAGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DLU1</accession>
    <name>A0A812DLU1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_57446</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003877">
        <property type="protein sequence ID" value="CAE1304877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DLU1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1304877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="400" mass="45992" checksum="057A15F264ADA47C" modified="2021-09-29" version="1">MSIAQIYKLHDTITFLPLTSVFIYPSVLLSIYLSISVLISLSIFISLSLCLQILSISLSLSPDFYLYLSLCLQILSISLSLSPDFYLYLSLCLQILSISLSVSRFYLYLSLCLQILSISLSVSSDFYLYLSLCLQILSISLSVSSDFYLYLSLCLQILSISLSVSSDFIYLSLCLQILSLSVSRFYLYLSLCLQIFIYISLCLQFYHLSLSPDFIYISLCVIRFYLYLSVCHQIFYLYLSLSQDLYLSLSHQIFYLSLSLHIFIYLSLSSDFLSISLSLFYLYLSLISFIYKQDFFIYISLSLCLQIISFCLILSIFSLCLQILSISLSQPSTFKYLSVKTKLYLYLSVCHQTLTLSMSQDLSSETHGWMNVNSPTQRDECMSTVRHREMNACQQSDTER</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DM15</accession>
    <name>A0A812DM15_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">HHEX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SPHA_54775</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003595">
        <property type="protein sequence ID" value="CAE1302017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DM15"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000721">
        <property type="entry name" value="Hematopoietically-expressed homeobox protein HHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051000">
        <property type="entry name" value="Homeobox_DNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324:SF5">
        <property type="entry name" value="HEMATOPOIETICALLY-EXPRESSED HOMEOBOX PROTEIN HHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324">
        <property type="entry name" value="HOMEOBOX PROTEIN HHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="246"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="283"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="319"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="392"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="11"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="13"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAE1302017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="420" mass="49401" checksum="68823F6B445E75C4" modified="2021-09-29" version="1">MWNHFVQRPLHKRKGGQVRFSNDQTVELEKKFETQKYLSPPERKRLAKLLHLTERQVKTWFQNRRAKWRRLKQMSYYDHALFTLFMLSYLHCYLNLIYLSIYLSIYLSRSVLYLSIYVSLFISIYLYLLIYMYLSLLISIFISKSVPYLSVDIYLSIYLSSIYLSILVCPYLSIYLSIYLSIYLSVDVYLSIEVFVPLLLLESQFQKPLFVIFTGYASPSLTNILIFIVLLSHYPTFSLPPIPSLYFFILSFFVIPLSLSHPFLLFFLVIISVFPPSVPFLSFFLSFFLSFFLSFFLFFLVIISVFPPSVPSLSFFLPFLFFLVIISVFPPSVPFLSFFLSFFLSFFLSFSQPISLRPFSAFFFIFLSLSLLFPSFSSFSSLSLLSFLSSLLFLYFSSFFSLSLYLSFTLPLSLFLSFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DMV7</accession>
    <name>A0A812DMV7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BHMT</fullName>
            <ecNumber evidence="6">2.1.1.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SPHA_57958</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Farmed</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.5" evidence="6"/>
    <dbReference type="EMBL" id="CAHIKZ030003932">
        <property type="protein sequence ID" value="CAE1305542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DMV7"/>
    <dbReference type="OrthoDB" id="261426at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047150">
        <property type="term" value="F:betaine-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.330">
        <property type="entry name" value="Homocysteine-binding-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003726">
        <property type="entry name" value="HCY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036589">
        <property type="entry name" value="HCY_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11103">
        <property type="entry name" value="SLR1189 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11103:SF18">
        <property type="entry name" value="SLR1189 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02574">
        <property type="entry name" value="S-methyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82282">
        <property type="entry name" value="Homocysteine S-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50970">
        <property type="entry name" value="HCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hcy-binding" evidence="5">
        <location>
            <begin position="1"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00034478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAE1305542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="383" mass="42383" checksum="3FA68E1E88F28770" modified="2021-09-29" version="1">MAGDLSNTTIFEPNNAEAIEKVKAMFKEQVIWAREEGADYIVTETFNTYEESALALEAVKEYGQGLPAVVTLATTAKSTTLEGIPISDTCRKLEEKGAAVVGLNCSRGPRMMVPLMKDIRQACKSLSISYSRLLSFSSQSLSISYSRLLSFSSQSLSISYSRLLSFSSQSLSISYSRLLSFSSQSLSISYSRLLSFSSQSLSISYSRLLSFSSPLFHFLFTSLLLLSVFSISYSRLLSFSSQSLSISYSRLLSFSSQSLSISYSRLLSFSSQSLSISYSRLLSFSSQSLSISYSRLLSFSSQSLSISYSRLPSFSSQSLSISYSRLLSYISLLLYPRFLSSTLFLLKTISIPQRVYSLPSLSRLKIGFETTVINITLNTTTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DRG2</accession>
    <name>A0A812DRG2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_61047</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004282">
        <property type="protein sequence ID" value="CAE1309289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DRG2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="406"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="441"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="469"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="504"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="532"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="563"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="589"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="614"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="643"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="671"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="697"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="726"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="756"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="812"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="866"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="893"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="956"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1010"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1038"/>
            <end position="1060"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1309289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1062" mass="118777" checksum="C95C93110942F847" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DSE4</accession>
    <name>A0A812DSE4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_61371</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004332">
        <property type="protein sequence ID" value="CAE1309662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DSE4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1309662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="175" mass="19430" checksum="DDBA77D02DFB3C39" modified="2021-09-29" version="1">MLLSIYLSIYLSIYLSIYLSQPSLSIYKSIYLFIYHILFIIYLYISFYSLSFFLSLSLSPRLRSGFLAGLGEQEASLIRDFDAPSQVDQAQQLTGLSSSSSSCSTHFTPRYCLPSVTPAHFCSFQLTPAPSSTPATSSSLLQHSCSFQQSPAHSYRFQLTPAVSSSPQQLLAALY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DXX8</accession>
    <name>A0A812DXX8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">OLFR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_61907</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004391">
        <property type="protein sequence ID" value="CAE1310319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DXX8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1310319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="225" mass="26462" checksum="D2DB5A76D41DC39F" modified="2021-09-29" version="1">MLLFLLSGFCLLSFCGRFPLPKLCTSIYRSTLSLFLFLFLSLSFSCSAVVLSETVWYLYSTSPLTFFLSLFLPAFLSPLFIFLLFLSFSNSFYLSLYHSFFLFSYFYYFLSFFLSFFLSFIHSFFLSFSSFLPFLSLLTIFLPLLFLLFPSLKAFIFHCVTLSSSFHTPLYFVCFFLFLFSLSLISILLSLYFVFSPQPLFILLSFCHWKLLSLLVFTFSYFFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DYK4</accession>
    <name>A0A812DYK4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_63105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004529">
        <property type="protein sequence ID" value="CAE1311754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DYK4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="303"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="328"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1311754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="387" mass="45902" checksum="D18D1315120D5F47" modified="2021-09-29" version="1">MYASLFSLFCFLRLLLNLSLCFLLLLHLFTLSLTLFSFHSLHLFPSFLLDIYCFLFLLSSFLSLSLYFSFFIFNTIYSSLYLSFSSPSFVLFLIFISSFFYPPSSFPSIPPPLLFLPPPVTFITLYYFLLLSSLLCPFIFFQLSRPLLSSILSLLVYISLFIFFPFYYILSFTLFFFHFLSSLYYSSFCSLLFIPPLSIILLYSSLLFSSFLHLHYFLSFYLFTNCLVLSFPPFNVITVNLSFFLFHVFICSYYLLFSSIHLYYSFLLFFFSIYSFVLSFFFLPSSFFTHCLNLSSFHPFLFINLYVLLLSFHLVFLFFIFRLYVYPLSFFPTLFPLFAHLSYSFSPFIFINLNLSILFFYFLSSFPSIFSFFFRLIHCSPLSSITH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DYX8</accession>
    <name>A0A812DYX8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_64115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004617">
        <property type="protein sequence ID" value="CAE1312948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DYX8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1312948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="275" mass="32550" checksum="3C54D1CEE7660B54" modified="2021-09-29" version="1">MYHPVHDNIYLSIYLSIYVHICWFTNFLSVYSVPLCSSFLSLIPVLINLLIDFVSPRFTGDAASKPDDHPFLFHISFLVCFFHYFLFPTFIFYNSFFFCCLFPFFLLVFSLFPSFFVVFSLLSFFLSFFLFSFFLSSISFVFLPFSIYFVLSSPPCSFNCFLFSSSMLPRPFLLHLLSKSVFDRFFFVHFLPSFLPSFLLYCFFLLSSSFFCYVFLFFPLIVFAVSLYFVYFLFFLRSFLRYWHISPFRTNELVNTTSCLGTSQPPPPFARRVAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DZL8</accession>
    <name>A0A812DZL8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_63173</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004531">
        <property type="protein sequence ID" value="CAE1311864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DZL8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1311864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="205" mass="24365" checksum="0E13B9B0D61DD49C" modified="2021-09-29" version="1">MSSNAVLQSIYLSIYLSIYLSIYLSLPLPFVFLFLSIYLSIYLSIYLSNSVHVNLFICFCYDKSNHCSHLSIYLSIYLSIYLSIYLSIIFHSFLIYLSIYLSAFYIYLVFPIYLSVYLFIYLGRIWLDLYISFYLSIYLSIYLSIYLSIYLFLYISSLLSIKDTALYLSYIYILDSPRRLLSIYLSIYLSIYLSIYLSIYLSQRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E0I2</accession>
    <name>A0A812E0I2_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Oxidoreductase NAD-binding domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SPHA_62475</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004471">
        <property type="protein sequence ID" value="CAE1310998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E0I2"/>
    <dbReference type="OrthoDB" id="436496at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00322">
        <property type="entry name" value="FNR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052128">
        <property type="entry name" value="Oxidoreductase_NAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46505">
        <property type="entry name" value="OXIDOREDUCTASE NAD-BINDING DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46505:SF1">
        <property type="entry name" value="OXIDOREDUCTASE NAD-BINDING DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="4">
        <location>
            <begin position="21"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00040516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAE1310998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="272" mass="31380" checksum="062A8E35B69C2DC4" modified="2021-09-29" version="1">MLTSFHSESSSKSNPSERRTIVDCPATVTEIWDMTPTVKSLNLFVNQYQFLDYKAGQWLEFKIPELKRMGSFTMCTSPLKFKKTGNIQLAVKYSDHKPTAWVHTNCKVGHQITISFGGDFHYNPTVDDPTHDLLLIGGGIGVNPLFCIMNLIADYNVMNKENNSRCYQPGNVQLLYSVRTVNDIQFKDNLEKLENENENISCKFFVTKEKPNDKNIINRRINSEDIKEALQKLDRGNCYIYICAPGEMMDDMEEILEDMEFDSSKIRTGRWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E0Z2</accession>
    <name>A0A812E0Z2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_64366</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004631">
        <property type="protein sequence ID" value="CAE1313219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E0Z2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1313219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="211" mass="24901" checksum="187970A8E5E63FE0" modified="2021-09-29" version="1">MATSLSPRKHIFFRSIYLSIYLSIYLSHLNQSIYLSYSLNLSINLSIFFYLSSIYLSIISIYLSIFFCHLFIIYLFISSIRIYLSIYLSIYLSIYLSIYLSLYTFMYFSLNGSIYLFIYLSLCTCMYVCIDLSQSMHIYLSIYLSIYLSIYLSIYLSLFNKSIYLSIYLSIYLSIYLSIYLVLLIIYLSIYLSIYLFLVCIGIIAFALMIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E206</accession>
    <name>A0A812E206_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NRF1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SPHA_66386</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NRF1/Ewg family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004787">
        <property type="protein sequence ID" value="CAE1315501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E206"/>
    <dbReference type="OrthoDB" id="10031051at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039142">
        <property type="entry name" value="NRF1/Ewg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019525">
        <property type="entry name" value="Nrf1_NLS/DNA-bd_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20338">
        <property type="entry name" value="NUCLEAR RESPIRATORY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10491">
        <property type="entry name" value="Nrf1_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Nuclear respiratory factor 1 NLS/DNA-binding dimerisation" evidence="7">
        <location>
            <begin position="39"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAE1315501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="509" mass="55913" checksum="CFDC0F2FCEF52B11" modified="2021-09-29" version="1">MLSDDISESSSQESAHFDEADLLTSPVNDDVTAQLAAAGPVGVAAAAAIATSRKRRRMHSFETNPSIRRRQQTRLLRKLRAIIEEYSTRVGQQAVVLCCTPGKPNQNYQSFKVFGSQPLETVVRNSKGIIMQDLESALAQQAPPSQQEDPNLHKLPRLVIDGIPTPVDKMTQAQLRAFIPEMLKYSTGRSKPGWGKAEYRPVWWPDDVPWANVRSDARSEEEKRKVSWTHALRQIVKNCYKHHGREDMLPEFTEENQASPPHQYAGTMVQTINNPDGTVSIIQIDTGTSGNSAVVTLADGTQATVVHAVPENHQQEATQAVQTLADAATHMETTGTGQPAPVRVEMNANSDAHTVATLAEATVNQDGQIILTGDPTTLGGKCLVDLTDGKWIVQSVDWADNSVPEIMRADKSVIKSEAIKKTNFVYITFRNNEEFQTAGLVSFPVSMFHNIATFKTTDINNQGNYRVASVNQHHHNGELSHQTLNDNHLSIGHADSSGVTMEVMAVDQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E3J8</accession>
    <name>A0A812E3J8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_65437</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004724">
        <property type="protein sequence ID" value="CAE1314588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E3J8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1314588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="153" mass="17899" checksum="714CB92C7A0F6895" modified="2021-09-29" version="1">MFLPILHSFLCSLSLYIISHLFSLYPSFYHSFLVCFFFSFLFFHSFLYTVTLRLCLCVCVSARVTVFVLLMPVFIIFIRTPARQPLTMRPQPSSPRQNIATDADDSQFIGEQRSNPNRSNDSFVYTFFHVVNINRRYKILALDSYVVYSGFLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E4S3</accession>
    <name>A0A812E4S3_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_67119</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004854">
        <property type="protein sequence ID" value="CAE1316388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E4S3"/>
    <dbReference type="OrthoDB" id="9909311at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF73">
        <property type="entry name" value="PROTEIN PDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="2">
        <location>
            <begin position="65"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1316388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="275" mass="30986" checksum="1ACFDAEDAFEC1536" modified="2021-09-29" version="1">MSASASQRKTLSISEQLELIDDVKVKKLKLAAAAKKYGIGYSTTAKILKKEDDLRSCMQMNGNTNRKRKRQSVHKDVNEALTQWFTQACAQGATVTDHVIRQKASQLAVNLEVDFEPSNGWLMRWKQVNNVSFKKFHGESTSADHGSANEWVTNVLPQLFRGYDPKDVWNCDETGIFYKAMPSGPLRFAGDEHSNGTKVPKDRLTMLQFTNMDGSEKQAVVVGKSAKLRCFKNVKTLPFSYFANRKAWKTSQLFTDVMNCSKSKDYSVFGQCNLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E5J3</accession>
    <name>A0A812E5J3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_66710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004817">
        <property type="protein sequence ID" value="CAE1315863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E5J3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1315863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="350" mass="41378" checksum="B75F93DFE48F3861" modified="2021-09-29" version="1">MFLPPGKFCYLHFKLEIIIKNRTFEIYLSIYLIYLYLHIYLFIHLSIYLSIYLSIYLSNYQSRHSSIYLSIYLSISIYLSIYLSVSVSSIYLSIYPFIYPSIYLIYLSISIYLSIYHLYLSVSISIYHLSHLFISIIYLSIHLSHSLHIYLSIYPSIYLNLSIYPSIYLSIYLSVPIYLSIYLSIHLSHPLSIHPSIYLHSSIHPSTSVSIYLSIYLSIHSSIYQSQSSSIYLSHLSLSSIYLSIYLSISPRYLYHLSIHLSSIYQSRSHSHYLSIYYLSHSFISIYLILYLSIYLSIYLSIYLSIYLSIYLFSFHIYPFNVLSIHFNVTFYIILLIEYNNPQTFSKKTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E6R4</accession>
    <name>A0A812E6R4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_69188</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005066">
        <property type="protein sequence ID" value="CAE1318706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E6R4"/>
    <dbReference type="OrthoDB" id="10684523at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1318706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="710" mass="79450" checksum="6C6A2F0B218C0D79" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E907</accession>
    <name>A0A812E907_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="16">HDAC6</fullName>
            <ecNumber evidence="16">3.5.1.98</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SPHA_69370</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Farmed</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the histone deacetylase family. HD type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="16"/>
    <dbReference type="EMBL" id="CAHIKZ030005072">
        <property type="protein sequence ID" value="CAE1318940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E907"/>
    <dbReference type="OrthoDB" id="424012at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000342">
        <property type="entry name" value="Histone deacetylase 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47665">
        <property type="entry name" value="HISTONE DEACETYLASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47665:SF1">
        <property type="entry name" value="HISTONE DEACETYLASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="8 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBP-type" evidence="15">
        <location>
            <begin position="67"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAE1318940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="167" mass="19197" checksum="9A62E3E8CA9A1395" modified="2021-09-29" version="1">MQSELSPLCIIQHRFLQFNECNLEPVRLAFFLIFEAGGFFLCPDGRDKYLQHLAKNHEAMFCVEPLKWCVHLEGSVKSVPDGGLDTSHPCETCGDTTENWVCLTCYKVFCSRYVHEHMVEHNKTEPDHNLALSYSDMSIWCYSCSQYLDNPILHSARDAACKHKFGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E9A9</accession>
    <name>A0A812E9A9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_69221</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005066">
        <property type="protein sequence ID" value="CAE1318754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E9A9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="273"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1318754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="292" mass="33152" checksum="55D054FC6799DD72" modified="2021-09-29" version="1">MVRLEPPSQIDHGEDLQYYSRFISIPTSYKLPTLILYFLPNLFFYSPSTHFLPSLLSSYSLSLLSSFSLSLHCFYSLSIQWPYSLSLFSLCCSYCCTSYPLLTIFLLSFSTLFLSLFLYTVSTLFPILLSFSTLFPFSLSLIAVSTLSSSLECCNLFLYSLYAVLLLLTSPSFTIFLISFSTLFLLSFSTLFLHTLSIQWPFSFLYSLYAVLLFLFLPSFHYLLYSLSLLSSSSLSLSPVSFSVPLNGLYSLSTAFFSPLLFLLLFPQYFPSLLLVLLHSLSLISSFYAFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E9N3</accession>
    <name>A0A812E9N3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_69085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005063">
        <property type="protein sequence ID" value="CAE1318674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E9N3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1318674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="180" mass="21409" checksum="EFE69E39D654AFCD" modified="2021-09-29" version="1">MISQFTHIYLSIYLSIYLSIYLSIYLSMSCLFHLSICVCMYVSIYLILFIFNLSIYLSIYLILLFHLLSSFSFSNLQAFRDRRFFFPLASSFFHRYTLSIYLSIYLSIYLSIYLSIYLSIYTGNDNTMSTLFPGNDLFLSLWKYIIFLHPTRHAIFVFPPTIHFRIPCDLCDKLNVCHLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ECE7</accession>
    <name>A0A812ECE7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PLCG2</fullName>
            <ecNumber evidence="2">3.1.4.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_72519</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="2"/>
    <dbReference type="EMBL" id="CAHIKZ030005329">
        <property type="protein sequence ID" value="CAE1322561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ECE7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1322561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="169" mass="20757" checksum="D11C6109F2AB85FE" modified="2021-09-29" version="1">MHLEFHSFFSFSFSLIIFCFFPVSSPFLFFLSSYFHVFFYYFFFFRIQKYFPSSYFILASSVFLPFFLSFSSFFSLLFFLSSFLSIFIFSSLHFFLYILLSIFLSFYLRFFLSSFLPIYFAFYLLYFLSSFFLSTFLSIFLSFIVFLLRFLRFLFISFFISFSCKFNIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ECV1</accession>
    <name>A0A812ECV1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_68532</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004986">
        <property type="protein sequence ID" value="CAE1318033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ECV1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="310"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1318033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="327" mass="38765" checksum="2C0730D19ADB6652" modified="2021-09-29" version="1">MLKRCSLIIPSLSLSLSLSIYLSSDRARYYIRFQSIYLSIYLSIYLSIYLSSPHSLDIIFGSYLSIIYLVLFIIYLSITSYIRERARYYIRFPFYLSIYLSIYLSIYLSLSIYSLSVLAIIFGSNLSIYLSIYLSIYLSIYLSSDRARYYIRFYLSIYLSIYLSIYLSIYLSSPVHYLSIYLSIYLSIYHIRYHIRFQSIYLSIYLSIYLSIYLSIYLSIYSLSVLATIFGSNLSIYLSIYLSIYLSIYLSIERTSYHIRFQSIYLSIYLLNFSLSVAFFFSFAIFSFFLSFTPLSNCYLFTLPLFSYEFPPLFSFLFINLFTLLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EDD6</accession>
    <name>A0A812EDD6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_71610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005241">
        <property type="protein sequence ID" value="CAE1321473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EDD6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="307"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="339"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="447"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="478"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="510"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="535"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="636"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="664"/>
            <end position="686"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1321473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="764" mass="86585" checksum="01E4DC763AD4798B" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EHI7</accession>
    <name>A0A812EHI7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_72421</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005323">
        <property type="protein sequence ID" value="CAE1322475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EHI7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1322475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="243" mass="27921" checksum="BDD48B04E70488C1" modified="2021-09-29" version="1">MCSPSSPSILCSLSDDSVNSKSIPFIPNCLEDRNDRCSKRICMDDVMSKLLDTAPSTSNLITSANENKVQSDTISTDEYITNCLSGEIDAKNQSENDFEKTDNMASLNKADDKHDVTYRNRIFHLRRSFSESALMLVKDGDVLMKEATDEQIQENLRSLRFDLDKLFNESEVIITKYVEHFWNFIEKTEEESTANNSQSPIPMSERLACIEDFTNTLRKEFKEYNNMIKRIVGEYKSFSLAFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EJ10</accession>
    <name>A0A812EJ10_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_74681</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005436">
        <property type="protein sequence ID" value="CAE1325003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EJ10"/>
    <dbReference type="OrthoDB" id="6160502at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052997">
        <property type="entry name" value="RRT15-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33047">
        <property type="entry name" value="PROTEIN TAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33047:SF8">
        <property type="entry name" value="REGULATOR OF RDNA TRANSCRIPTION PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69304">
        <property type="entry name" value="Tricorn protease N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1325003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="219" mass="23400" checksum="A8D07700B194B11D" modified="2021-09-29" version="1">MIGRADIEGSKSDVATNAWPPQASYPCGNFSDTSRRNGAHRSEMIDGPRFRGPSCKFSQDGGEAELTVQFSTDNSSCKFSQDGGEAELTVQFSTDNSSCKFSQDGGEAELTVQFSTDNSSCKFSQDGGEAELTVQFSTDNSSCKFSQDGGEAELTVQFSTDNSSCKFSQDGGEAELTVQFSTDNSSCKFSQDGGEAELTVQFSTDNSSCKFNQDGGKQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EL62</accession>
    <name>A0A812EL62_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_77913</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005525">
        <property type="protein sequence ID" value="CAE1328332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EL62"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="334"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1328332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="362" mass="44178" checksum="749F234DA5AC25F7" modified="2021-09-29" version="1">MPDEIIIGAIFSLSLSLSVSQFAHYLSIYLSIYLSIYLSDTVDIYLSIYLSIYLSIYLSLCLPTSISMQTVAGNGFFVRIVSSFLFLFNLINYILTILYFTNYLSFLLFLFLSIFLFSFNFLFSFFLPFLSLSFLRCFFFFLFPFFLFSFFFFFLFSFFFFYLFFFSFFFSFFFSFSFFLSFFLPFLSLSFLRCFFPSFSLSLNFSFFLSFFLSFFHFYLFFLRCFFPSFSLSLNFSFFFFFFFFLSLFLPFFISFFLPFFFFFSLFFLFFFFSFFFLFPFYLFLFCCFFPSFFSLLNFFFFSFFLSFFFLPFLSLSFFASFPSFSLSFNFSFFSFFLSFFLSSIFISFFFALLLSFFFSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EL96</accession>
    <name>A0A812EL96_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_76644</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005495">
        <property type="protein sequence ID" value="CAE1327137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EL96"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1327137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="180" mass="21127" checksum="3029A4296943DC3B" modified="2021-09-29" version="1">MKARLATADSFNINLLPFRLEYLSFFRSLFFSIYLSIYLSIYLSIYLSQYISTCFFVSFFLSLLNLSIYLSIYLSIYLSIYLSLDFDLILLSFFSSFMLSLYFYFLSHSVRISLSIYLSVCRSIYLSIYLLIHSFRIYLLTRTSLSFSSHTLSIYLSIYLSIYLSIYLSISGKSGANIYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ELF9</accession>
    <name>A0A812ELF9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_74616</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005435">
        <property type="protein sequence ID" value="CAE1324958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ELF9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="341"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="396"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="425"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="452"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="490"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="529"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="572"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="598"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1324958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="644" mass="76817" checksum="8D42CD069EB6E0F6" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EMU8</accession>
    <name>A0A812EMU8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FOXN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_76613</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005494">
        <property type="protein sequence ID" value="CAE1327065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EMU8"/>
    <dbReference type="OrthoDB" id="10687988at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="183"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="375"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="560"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="560"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="603"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="633"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="684"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="720"/>
            <end position="735"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1327065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="839" mass="91828" checksum="CCA579197C29DABB" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EP79</accession>
    <name>A0A812EP79_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein Wnt</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SPHA_76096</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Farmed</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Ligand for members of the frizzled family of seven transmembrane receptors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Secreted</location>
            <location evidence="1 8">Extracellular space</location>
            <location evidence="1 8">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Wnt family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005480">
        <property type="protein sequence ID" value="CAE1326519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EP79"/>
    <dbReference type="OrthoDB" id="5945655at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005109">
        <property type="term" value="F:frizzled binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045165">
        <property type="term" value="P:cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005817">
        <property type="entry name" value="Wnt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027:SF98">
        <property type="entry name" value="PROTEIN WNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027">
        <property type="entry name" value="WNT RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00110">
        <property type="entry name" value="wnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01349">
        <property type="entry name" value="WNTPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00097">
        <property type="entry name" value="WNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="6 8" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032494899" description="Protein Wnt" evidence="9">
        <location>
            <begin position="25"/>
            <end position="915"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAE1326519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="915" mass="100911" checksum="0CA98FF763B7D7A6" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EVB2</accession>
    <name>A0A812EVB2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_80524</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005600">
        <property type="protein sequence ID" value="CAE1331322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EVB2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="324"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1331322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="352" mass="41566" checksum="619724C98DDDFBED" modified="2021-09-29" version="1">MSCWLHLSIYLSIDLSIDLSVCLSLYLSICFHASLALSIYLSLFISFSSSYRRLIYLSIYLSIYLSIYLSIYLSIYLSVYVSKPFRVFFFLCIASSCRFCSYLSIYLSIYLSIYLSQSFSYLSIYLSQSFSYLSISVLFISIYLSIYLSPFHIYLSIYLSQSSIYLSIYLSIYLSISVLFIYLSIYLSIYLSIYLSISFFLSFFLSFFSVALGRLLSFFLSLFIQSFFFIACFFLFFFFFPSFFIAFSFFLSFFLSFFFIVPARLLSFFLCSSSLSFFIVYFFLSFSFFFFLFLSFFLCFFVSFPSLQANLLLSFFVHPVFPSLLIFSFFLLLSFFLSFFLFSFFLLLTNNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EWU4</accession>
    <name>A0A812EWU4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_79129</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005558">
        <property type="protein sequence ID" value="CAE1329704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EWU4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1329704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="254" mass="31249" checksum="AE6F8F31707B0130" modified="2021-09-29" version="1">MSALPQNTASSSSSSNTSHLILFLLFFNFHLFSSLLFLLIHFILKFFRIFLFSCFLFFSLFLFSFFFSLLLFFLYFSFFIFLSFLILFLTLSLLFLFSLLLSFSLIIFLSFSVFLILSFFISFSFFFFSSFFFLCHYSVFFSSFYIISLLITSFIFTFLFCFLFHYFFFSLFLFSLFLFYFFLSFFFLFPYLFSLHLFLFLLLPSSSLPILRLFYFCYCFFFFFFFFFFFFFFFLNKKKKLNKLIRKSMHFFLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812F1Q4</accession>
    <name>A0A812F1Q4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_81081</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005622">
        <property type="protein sequence ID" value="CAE1331968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812F1Q4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1331968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="252" mass="28764" checksum="4146B57F0E0E0F8F" modified="2021-09-29" version="1">MKVRSLPLRRSYSIRNDGKIIIGFHIYLSIYLSIYLSIYQICDIYTHLSLSLSLSLSIYLSIYLSIYLSIYLSIYTYSYLSIYLIFSFFLLASMIDSFLPSFLPSFLLSFYLLPSIFLFLNSILSFSFLSSFFQLIYDHVESNLVSQYHSISLSLSIYSCITFHAAVVAVSAVVAVEDDTVAVAKELYIFNTFFLIRTLSCMDLSGSFSPIQCPALQEITTAPPKPFLRFFKRVSRFTYSQAHLAIKGSIHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AJ96</accession>
    <name>A0A812AJ96_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heme-copper oxidase subunit III family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_1365</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
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    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1159586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="220" mass="26910" checksum="A82125CB46F6809D" modified="2021-09-29" version="1">MMGSVYMCFFVRPVYPHLFASSRRIILSFYFYSGLSSFFLSIFSFFLSFFLSFFLSFKVSFSLDFFFSHFHSNVLSLFRVVFRDYFRNSKTSFFLSFFLSFFQAFFLSRFLFFSLFLSRFLSFCLSFSFLLSFFLSFFIYLFIYLFLDLFQGFFKISFFQAFFLHFSFILSFLYSFFPSFFLSFYISFFLAFFTLEEYTIYLIMLLSIYLSIYLSIYLFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AXA6</accession>
    <name>A0A812AXA6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_7351</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000236">
        <property type="protein sequence ID" value="CAE1162438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AXA6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="274"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="308"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="336"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1162438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="360" mass="41945" checksum="A378E5F879870C92" modified="2021-09-29" version="1">MDPFEASLKLQALITPFIFPFFKRIPISISRTLRLSLDHSVLSATLYASSAFFLSFYCTLSSTLPPSTLQLLLLLLLLLFFFFFFFFFFFFFFFFFFFFSSCFSFNSSSSFVCFHLPILLRLLILTVMALLLLLILWFIHFFCFILFLLFSSFLFLFFSFLFLSSYSSSSFFFFFFFFFFFFFFPASSSFFFFFFFPSLVSIVLIQLLLLFWCCCRCCAGSSSSSSSSSSSSSSSSSSHSCPSFVCFHLPILLQLLILTVIGVVVLVVDIVVHPLLFFSFFFFFFLLPLFLFLLLLFFFFLFPFSLHLVLLLLSRLLLLLLLSIFSLYRLNPVVDVVVVAILLLLLLLLLLLLLLLLLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AXS0</accession>
    <name>A0A812AXS0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_6692</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000219">
        <property type="protein sequence ID" value="CAE1161091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AXS0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1161091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="266" mass="31931" checksum="7ED69388A4138F93" modified="2021-09-29" version="1">MQIAFYLSIYLSIYLSIYLSVTIAICFFLSIYRPIYPSLFICKLFISIYLSIYLSIYLSICLCTGYLSIYLSIYLSIYLSLFVIYLSIYLSIYLSIYLILVFIYLYIYLILFFIYLSISIYIYIFSQSIYLSIYLSIYLSIYLINGKIHLKSNMFFISIYLSIYLSIYLSIRLFLFKYFSYFLLLNLYSTHFLSFFPSFFLTFFTYLSLSIPFYLSIYLSIYLSIYLSLSILFKYFSYFLLHDLYTFLSFHLSIYLSIFLSIFLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B1X3</accession>
    <name>A0A812B1X3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_9148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000293">
        <property type="protein sequence ID" value="CAE1166940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B1X3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1166940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="155" mass="18776" checksum="08531A14103555A0" modified="2021-09-29" version="1">MHIFFSLSFFLSFFLFLLSSFCLSPFSPFFYFTFFFFFFFRLFFFYLRYLHYQPDLHHQCQLPPHMTVKPPSSSLTTITSYMTSSTTVKSNTTNKTPTVTSRKISYLDFFIPLFFISFLFLSFFLSFFLSFFLYFIKHYLFFVKQSDTPKCFSIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B225</accession>
    <name>A0A812B225_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_8601</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000280">
        <property type="protein sequence ID" value="CAE1165857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B225"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1165857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="179" mass="19988" checksum="82A5B75A7212E0BC" modified="2021-09-29" version="1">MFPSTSSKPSLATVNSSFFPPPFLLFFSFFLFLLFLFSLLLFFSSASFSSFSLSPSSFSSLLLLSPLFLFLPLPPPPFLPFCFFLLFLPLPPLPFLFLSLFLPLPLLLSPLFLSSSSSSSFSPSSFSPPHFLSPPPLLLPFPPLTFSPFSFLFFLLFFFFFLFSSCSSSPPPPFTKSVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B238</accession>
    <name>A0A812B238_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_9962</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000319">
        <property type="protein sequence ID" value="CAE1168268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B238"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1168268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="150" mass="16287" checksum="43B1F339528738E4" modified="2021-09-29" version="1">MTNVLVGSSTAGQVVSFFSLFFSLSLLCLSLFFSLSSSLSPLSVSLFFSLSLSLSFFLSLSLSLSPLFSLSLCLSLFFSLSSVSLFFFYLSPLSLSFFSLSLLCLSLFFLSLSSVSLFFFSLSPLSLSFFSLSLLCLSPTLFLPLSTNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B2B0</accession>
    <name>A0A812B2B0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_7964</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
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            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000258">
        <property type="protein sequence ID" value="CAE1164307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B2B0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="55"/>
            <end position="77"/>
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            <begin position="89"/>
            <end position="110"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="122"/>
            <end position="146"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="158"/>
            <end position="180"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1164307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="378" mass="44452" checksum="EE2832054AE26448" modified="2021-09-29" version="1">MTNYTIYLSIYLSIYLSQSVSISFPETYDAYSFRFLTLLISCHSFFPYFPFFLSFFLSFFLSFFLSFFLSFFLSFLYNNHSAQKSYVSLEYLSFFLSFFLSFFLFSIIIILPKRYVNFYLSIYLSIYLSIYLSIYLSFILFISIYLSIYLSIYLSIYLSIYPILLTSIYLSIYLSIYLSIYLSHCVHIYLSIYLSIYLSIYPILPIFSSIYLSIYLSIYLSIYLILFISIYLSIYLSIYLSIYLFEPVYIYLSIYLSIYLSIYLSIYLSIYYHDALFYLIHYYASILLSPIIPSFPSSNLLLNLTLYPAYSKSLLLRILNSFSYHPSPYAHPSPSLRRCLNSVSPDLNLHYPSLSLISSSPPLILHPSLSVLTYPALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B2U9</accession>
    <name>A0A812B2U9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_9068</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000291">
        <property type="protein sequence ID" value="CAE1166790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B2U9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1166790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="174" mass="20678" checksum="91BBE48FA8E23237" modified="2021-09-29" version="1">MRFLSFFLSPVLSFFLSFFLSFFLDVFLSFCFFFLTGSSFPAAFIFFLSFFLSFFLSFFLSAFPFFLFLLSNWVFLSGCFYFSFWMLLPSLFIPSFLPSFLPSFLPSCLSFFLSFWMLFLSFFLPFFLSFLMLFLSFFFFFLTGSSFPAAFIFLSGCFFLLSFFLPFFLSFFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B3M2</accession>
    <name>A0A812B3M2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_12242</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
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                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000407">
        <property type="protein sequence ID" value="CAE1172748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B3M2"/>
    <dbReference type="Proteomes" id="UP000597762">
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            <begin position="12"/>
            <end position="31"/>
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            <begin position="37"/>
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            <begin position="116"/>
            <end position="141"/>
        </location>
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            <begin position="188"/>
            <end position="210"/>
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    </feature>
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            <begin position="222"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1172748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="249" mass="29843" checksum="20BDAA6C9B4BB86E" modified="2021-09-29" version="1">MNLYTLSKSKFFLYLSIYLSIYLSIYLYIYINNSFFPWTFFLSFFLSFHPPFLISYLLVNAENCSLVNKILSIYLSIYLSVCLSVFINIYLSLFISLSLSLSLSQFLYRSQSSLSIYLSIYLSIYLSTSVYYLSIYLSIYLSIYLSIYLSTSVYYLSIYLSIKLSISVYLSFIYLLQSIHYLSIYLSIYLYIYIYIYIYIYIYFSLFIIYQSMYLSIYLSIYLIQSIHYLSIYFNLSIYLSIYLSIYLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B526</accession>
    <name>A0A812B526_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_9345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
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                <person name="Bekaert M."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
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    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="CAE1167342.1"/>
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            <begin position="321"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="381"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="415"/>
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        </location>
    </feature>
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    </feature>
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        <location>
            <begin position="658"/>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAE1167342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="686" mass="83513" checksum="87A2BC88ABC2DBB5" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B5A3</accession>
    <name>A0A812B5A3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">SPHA_10709</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000349">
        <property type="protein sequence ID" value="CAE1169734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B5A3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1169734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="225" mass="24498" checksum="24488DFC44218B81" modified="2021-09-29" version="1">MLSRASLFCLVDHTTCLFNHHHTSKATTIISIIPTTVGQVIIATQFSLQPEFGVPILSNSDFNHPRSIGLNNTGIFSSNILGISLTMGLHNPVHPLVFVPNSCNKTKENSSSSLRLGSIPASPECPAGVQFTSLSLRRGLQFLPLGPPGWGRARMTLFSQTSNPFLPSIRVRIVPFGPSFSCEDRFISGDPLLHSANTFAPYKWPKSARPHHMSSISEVLLALAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B6H8</accession>
    <name>A0A812B6H8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_12314</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000412">
        <property type="protein sequence ID" value="CAE1172906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B6H8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1172906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="238" mass="30805" checksum="F5121F3BE31EBC55" modified="2021-09-29" version="1">MDDTFFFIFLFFFLLVFIFVLFFSFFFDFSFSLFVFSFSLFFVFSFPSLFLYFLFPLFFCIFFSLFFFVFSFPSLFFYFLFPLFFFVFSFPLFFFCIFFSLSFFVFSFPSFFFYFLFPLFFFLYFLFPLFFFLYFLFPLFFFCIFFSLFFFFFLYFLFLFFFFCIFFSLFFFLYFLFPLFFFFVFSFPSFFFILFSFFFFFFPFFFFFLFPLFFFIFFSLFFFCIFLFLFFFLYFFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B8Q2</accession>
    <name>A0A812B8Q2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RASSF9_10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SPHA_12924</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000432">
        <property type="protein sequence ID" value="CAE1174018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B8Q2"/>
    <dbReference type="OrthoDB" id="10034447at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16123">
        <property type="entry name" value="RA_RASSF7_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033593">
        <property type="entry name" value="N-RASSF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15286:SF1">
        <property type="entry name" value="FI07216P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15286">
        <property type="entry name" value="RAS-ASSOCIATING DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-associating" evidence="3">
        <location>
            <begin position="23"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="501"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="593"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="656"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="692"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="189"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="361"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="521"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="531"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="708"/>
            <end position="722"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAE1174018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="722" mass="82184" checksum="007EB3C06489D324" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BB50</accession>
    <name>A0A812BB50_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7041 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_16531</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000583">
        <property type="protein sequence ID" value="CAE1227778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BB50"/>
    <dbReference type="OrthoDB" id="6251906at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055469">
        <property type="entry name" value="DUF7041"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327">
        <property type="entry name" value="ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327:SF3">
        <property type="entry name" value="RNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23055">
        <property type="entry name" value="DUF7041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7041" evidence="1">
        <location>
            <begin position="21"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1227778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="270" mass="30861" checksum="D1D726C0DC6B8A23" modified="2021-09-29" version="1">MATDEWEQNTLINVAMPLTNLPPYNEQNTKNWFLQLEAIFSVRKITSQQAKFVNVVQVLPPSVVDEVADILEHVPEQEPYTRLKEAILKRTGRSDEELLRELFTHVTRGDRTPSQLLRFMRSRLGKHSMAESILRELWMDKLPTTITQILAPIADNTPLDQLANSADRIATKLDQGVCAVQRPDDTSAKETDLEKAVADLQHQLQDIRMLLSRTSRGPMPATGGWRRRARSTSRGRRVDPELCWYHHRFGTRAKNCSAPCKYSSKTKSEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BDP8</accession>
    <name>A0A812BDP8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_15579</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000543">
        <property type="protein sequence ID" value="CAE1224955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BDP8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1224955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="177" mass="20057" checksum="2D6E1576C7F0D806" modified="2021-09-29" version="1">MSNKERPAFSPTYSPSFCHFPVLFLLFLQTIPPSLLLIRSFSFIPSLSLSLSLSYSYTTSDYTTPIVSLFYNISIFFINFIPSFFLSVFISVFFSFFLLFFIFSLSLSLSLSLSLSLSLSHADTKTHTNTRPLTVDVCFFLFLVFLSFLFLFPSFTLSLSLSLSLSLSLSLSLHTHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BG04</accession>
    <name>A0A812BG04_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_16049</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000560">
        <property type="protein sequence ID" value="CAE1226521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BG04"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1226521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="225" mass="24770" checksum="AE13AB856E7BF1A4" modified="2021-09-29" version="1">MLPFPGNTNFLPLILPHLAIGRNLIKRTRYFITHPPLLSPPPPMPPQDYICDCFVFPPHFHLYNPFSSVLFFFSSLLFFQRSGSACLISLEALPRKDASRGQEVATQSARLIRDIHFFLPSPFGLLAPFSSPSSLPFLYLHPSLPPHPFLLFTLPFTLLSLSSPSLSLSSPSLSLSSPSLSLSSPSLSLSSPSLSLSSPSLPSFFIFTLPAVCVFPPLSRKIFIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BGH6</accession>
    <name>A0A812BGH6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_16366</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000574">
        <property type="protein sequence ID" value="CAE1227384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BGH6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1227384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="369" mass="43711" checksum="2459766D370164D1" modified="2021-09-29" version="1">MPHEITSHVIASSGLQFRAYLSIYLSIYLGLFISMYPSLYVGLFISIYLSIYLSIYLSIYRGLFISMYQSLYVGLFISIYLSIYLSIYLSIYLSIYLMIAACSYLSIYLSIYLSIYLSMLACYLSVDRSIDRGLFISIYLSIYLSIYLSIYRGLLFIYLSIYLSIYLSMLACYLSIDRSIDRGLFISIYLSIYLSIYLSIYRGLFISMYPFLYVGLFISIYLSIYLSIYLSIYLCLYYLLFLSFFPFFFLCRHRGSVYLSPFYSFLLFSSPFSFFLCNCFLYSSDFLHSLFNQFLPRLFYFFFHLILPASLKLFSFVRPLIVIRTITFFFLFHLLRLALPFLIFSILFSFSHAIPSFFTFFYFFLSLTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BJF4</accession>
    <name>A0A812BJF4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_18507</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000668">
        <property type="protein sequence ID" value="CAE1232298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BJF4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="131"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="192"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1232298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="363" mass="43189" checksum="630F945A57AA8FEF" modified="2021-09-29" version="1">MEYTKKDGPFSTNVNDNMSEKYAAMKEGKDRLEKFNKRGGNRKGGKETDKGGNRGDRVSRETGSGSAAQSEDELDELRPGYQKKKRRRRHSHMSASITSESTTTTMLSNLTNAPINVEKKKSSYAYYECSAWVHTAIVIYEFEFFFHSALFVNLFFFHSFPSFIFSSIYFLFFSFLFFFFYLIVYHFSYNSYLYILSFFSFFAFLFFFIPAYFLSFFFLCLFPSICLAPLSYTFILFNFMFSFLHTFLYSFSSLFLLHSHNISYFISYSFFLSLFILYILYNFFFKLYMSYITLSSFSFFLYRIFHHIPIIFPFYLPRSLFLLLILSSLFFYFSPHSLSVYLSLFPLSFIFIILSSFQPCYIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BLS5</accession>
    <name>A0A812BLS5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_22880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000846">
        <property type="protein sequence ID" value="CAE1241471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BLS5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1241471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="335" mass="39335" checksum="83529CC70AD407B3" modified="2021-09-29" version="1">MFDTCKRKGEIGKGYGIYLSIYLSIYLSKSIHIFLSKPIRYLSIYLFVSIYLSIYLSIHIYIYINLVSCLSIYLSIHIYIYINLVVSIYLSIYLSIYLSMRSQLYRCIAPQHFCLRFIPSCPIYLSIYLSIYLSIYLSMSIHDLSIYLSIYLSIYLSIYLSIYVHTSIYLSIYLSIYLSIYLSISIHDLSICIFIVNTIMAQGEICICLSISICSYLSLNKLCYFPYLFVCIYNCLFFCIILPIYLSIYLSIYLSIYLSISTCSYFLPIDFDTFHMYKSKTVRFCAFFHVSENNMIYLSIYLSIYLSIYLSIYLCPCTIYLSIYLSIYSEVKSIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BRN8</accession>
    <name>A0A812BRN8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_22352</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000825">
        <property type="protein sequence ID" value="CAE1240487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BRN8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="322"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1240487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="382" mass="45656" checksum="B407FCCEC0BD6432" modified="2021-09-29" version="1">MNYCSFCFIHVIFRPILFDFSSFFLSFFLLHPPKFFLSFFIPPSFFFPFPPTFFLSFFLSFFLSFFLCLLSSFSPFCLSVYLPLFFLHPSSFFLPFSLSIGLSFILSFFLSFFFYFHLPSFLALLSSFSPFCLRSVCLAVFLSFSISINLINFFLSFFLSFFLSFFLSFFFFIHPSSFFLPFSPFVGVSFILSFFLSFSISTCLISFFLSFFLSFFLSFLTLLSSFSPFCLSVCRSLFFPHPYSFFLPSSPFVDLSFFLSFSISTNLISFFLSFFLSFLFYFYQPNFFLSFFLSFFFYFYQPNFFLSFFLSFFLSFSISTNLISFFLSFFLSFFLLYPATFFLFSFQLLSFFFDFHFFLSFLFFYLCFLSVHLQFFFKFFPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BRV4</accession>
    <name>A0A812BRV4_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_22432</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000829">
        <property type="protein sequence ID" value="CAE1240671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BRV4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032713481" description="NADH dehydrogenase subunit 6" evidence="2">
        <location>
            <begin position="18"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1240671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="179" mass="21128" checksum="BF10E99760A0850F" modified="2021-09-29" version="1">MGLFVAILFLFAQIVHDNMYVHNQVWDPYQILWNNDIYLSIYLSIYLSIYLSIYLSIPIIYLSIYLSIYLSIHLYQYPPIIHLSIYSSIYLSIYLSQYPIIYLSIHLSIYLSIYLSQYPHYSSIYLSIYLSIYLSISISTSVEMTRTCSQKRLKLTDHVGPHLDIKAQKKPRRTQGDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BTZ5</accession>
    <name>A0A812BTZ5_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mediator of RNA polymerase II transcription subunit 22</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Mediator complex subunit 22</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SPHA_26893</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Farmed</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001028">
        <property type="protein sequence ID" value="CAE1249950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BTZ5"/>
    <dbReference type="OrthoDB" id="203279at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009332">
        <property type="entry name" value="Med22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12434">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12434:SF6">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06179">
        <property type="entry name" value="Med22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAE1249950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="170" mass="19920" checksum="5B15472546A2808D" modified="2021-09-29" version="1">MPFFDGKGSNCKYNFRISCFSLNCIMSHPVRTLPQSKEALLRSYNKRLKDDIKSMVENFKEIIKLARVCRIVEDDTQISRMTQAEQDQYEMQVRAANIVRAGESLMKLVSDLKQFLILNDFPSVNEFIGQKTKLYKQKQSELDNKLLALRDDMATELFELEDEYYSCVYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BUT2</accession>
    <name>A0A812BUT2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_24040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000891">
        <property type="protein sequence ID" value="CAE1243845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BUT2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="299"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="335"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1243845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="376" mass="45806" checksum="0CE8CA75185ACF36" modified="2021-09-29" version="1">MFVDMLTSERVASFAELSFEIQTKYQSFFFTSSFFLFHNSSFFISFFHSFILSFYFFHPVLLSSLISICLFVFTFVSFLQNSFFPFLFPSLFSFSIVFLRSIFLSPSLSLFTFLSFFLSFHLFLYLFATLFIFFLYSFFISFSLCLVLFTFLSFFLSLFFHSSYFFLSFVISYFLYFLSSSLLFMTISTLFFISFLFHFTPLSFFRSFFLSFFLSFFLSFFLSFFLSFFLSFFFPFLFVSCLNSLILICFLLPSFFFLYLLPYFCPYLPSFFLSFFLSFFLSFFLSPLFPSLFPFPSSFFLTFFHSFLIYLFFLYFLLFLYSWISFPLYFLQNSFIPLSFFPFFSYLFRSFFFFMSFSFFQRFPYIFFDKFHFQIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BVU6</accession>
    <name>A0A812BVU6_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Hydroxysteroid dehydrogenase-like protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SPHA_24942</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000941">
        <property type="protein sequence ID" value="CAE1245963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BVU6"/>
    <dbReference type="OrthoDB" id="5327538at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09762">
        <property type="entry name" value="HSDL2_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000301">
        <property type="entry name" value="Hydroxysteroid dehydrogenase like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="entry name" value="SCP2 sterol-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051935">
        <property type="entry name" value="HSDL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006133">
        <property type="entry name" value="PRK08278.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42808">
        <property type="entry name" value="HYDROXYSTEROID DEHYDROGENASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42808:SF3">
        <property type="entry name" value="HYDROXYSTEROID DEHYDROGENASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAE1245963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="558" mass="62073" checksum="323A4945BE8225E6" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BVX4</accession>
    <name>A0A812BVX4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_25074</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000947">
        <property type="protein sequence ID" value="CAE1246245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BVX4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1246245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="253" mass="29983" checksum="2636AFC1A678BF28" modified="2021-09-29" version="1">MVRNPIPINARSGTKRSAARLQIFRGHVLDNPRSGTKWSAVRYQMVRGPVPNGPRSETKWSAVRYQMVRGPVPNGPRSGTKWSAVRNQMVRGPVPNGPRSGTKWSAVRYQMVRGPVPNGPRSGTKWSAVRYQMVRGPFFFLSFFLSFFLSFLYFFTCYFLCFCLFFFLLFFRHFFVSFFPFLSFFLSFFDCVFLSFFDPFLFFFLIFFLSFFLFSYLFSFFPFSRLIFFHFSVFSFFSFFVSFFMSCYLSFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BWN9</accession>
    <name>A0A812BWN9_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zasp-like motif domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SPHA_23538</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000870">
        <property type="protein sequence ID" value="CAE1242928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BWN9"/>
    <dbReference type="OrthoDB" id="1293114at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031847">
        <property type="entry name" value="PDLI1-4/Zasp-like_mid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006643">
        <property type="entry name" value="Zasp-like_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15936">
        <property type="entry name" value="DUF4749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00735">
        <property type="entry name" value="ZM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="Zasp-like motif" evidence="3">
        <location>
            <begin position="131"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAE1242928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="230" mass="24762" checksum="89E425CA85F97F92" modified="2021-09-29" version="1">MKVFIQKAHKPSIYLSIYLSIFFTIFFFFSLSLSLSLSLALSLSLSCNLAHSLTHALGAVTIWKPTVTPLSELRPSELKPIISATGEEIIAVQKTSLAKEKPDDICTIGSSHNRSARPFGAASGPQDSGPSVIHAQFNSPIGMYSAENLAETYSEQASSLRENMANMNVSGQAGRPQPMIPASAPGENSQASNVSSDEVLPHDGHATTFGRLEDELNKKEVDSMYTNCTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BX54</accession>
    <name>A0A812BX54_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">HCRTR2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SPHA_25177</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000953">
        <property type="protein sequence ID" value="CAE1246465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BX54"/>
    <dbReference type="OrthoDB" id="6157309at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007218">
        <property type="term" value="P:neuropeptide signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24230">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24230:SF0">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="156"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="295"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="7"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAE1246465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="343" mass="38805" checksum="CB5E250A6B3BE18E" modified="2021-09-29" version="1">MVFGAVGNSAVSYIYYCKLEKTATNLFVAVLSACDLLSCLISMPVEIVGLRFPLTFHSDIACRLIRFVVAMGTITSALIIFIISVDRYLRVCRPLGRHFSRRSAKIASTVMVFSSMVLASPAFLVFGKRRIQTRISDIVGEECSIAEGLTNTNYPLAYYCSLLVTCFVLFVVLMALYFLIGIYVWRHKKKNKGRMQKVVFTHPSNDRMSATISSSSGNVEEDLKLHKPTRHKVSRPISSPVDHRQPTSVRVSRTTVIMFLITLLWIVSYLPHLVMVTCEIVVKNFRTSLGTTGDVLYNLSFRSYFFNNAINPFIYGIFNLRFRKELFILLDNVFGACSCKRSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BXB1</accession>
    <name>A0A812BXB1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CRNS1</fullName>
            <ecNumber evidence="1">6.3.2.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_24676</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.11" evidence="1"/>
    <dbReference type="EMBL" id="CAHIKZ030000924">
        <property type="protein sequence ID" value="CAE1245262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BXB1"/>
    <dbReference type="OrthoDB" id="6109609at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047730">
        <property type="term" value="F:carnosine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035499">
        <property type="term" value="P:carnosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031046">
        <property type="entry name" value="CARNS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48066">
        <property type="entry name" value="CARNOSINE SYNTHASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48066:SF1">
        <property type="entry name" value="CARNOSINE SYNTHASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1245262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="514" mass="58121" checksum="FB20C17EE634AE45" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BXG9</accession>
    <name>A0A812BXG9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_25929</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000988">
        <property type="protein sequence ID" value="CAE1247974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BXG9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1247974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="189" mass="22500" checksum="9716DF795A615EDC" modified="2021-09-29" version="1">MTLYFSSSSSSPLSSPFLFLSIYLSIYHYIYIYIYLCVCVFFSVYFFRLLSFSIYLSIYLSIYLSIYLSFSLFISFIFFSLSFSSFFLSFILFFFYALHFCLFLFTPLYFSSSSSSLHSSLFLFLSIYLSIYLSIYLSIYLSIYLSILIFLSFSLLSSVSYLKNFFFSSIYSFIFSFFYFRTNLSRHSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BXS1</accession>
    <name>A0A812BXS1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_24593</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000920">
        <property type="protein sequence ID" value="CAE1245105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BXS1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1245105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="150" mass="17845" checksum="A0E3E1D87E0B38BB" modified="2021-09-29" version="1">MLRCLRGKKSWKHDLKVADMRKVESKRLNLLESKSYITYHHAEDMNSRFHEFNLQTILSLDIFKSFFLSRICLSFFLSFFLSRICLSFFLSFFLSFFLSSICLPFSYLSFSFFLSHICLSFFLSFFLSFSSLFSFLVSVFHSFSSFVLPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BYE0</accession>
    <name>A0A812BYE0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_25882</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000985">
        <property type="protein sequence ID" value="CAE1247881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BYE0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1247881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="279" mass="32632" checksum="1D1D68373B1CFE01" modified="2021-09-29" version="1">MEFFLSFQLIEAVSSYLSIYLSIYLSIYHDMPIYFAVSLSISIYLSIYLSIYLSIYLSFSICSYLFHIFLRQSSHIHRFMYLNLLISIYLSLLTSIYLSIYLSIYLSIYLSISTCSYLSHSAHVYRTIYLNLLISIDLCISICSYLSIYLSIYLSIYNDLSIYLSIYLSITIYLSICQSVSPYLSIYLSIYLSIYHAIPIYLSVSLSISIYLSIYLSIYLSRYTYLFVSQSLHIYLSIYLSIYLSILFDQNHIHSQPLLDLNLYISFCFPTTSIESSFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BYJ4</accession>
    <name>A0A812BYJ4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_24541</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000916">
        <property type="protein sequence ID" value="CAE1244956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BYJ4"/>
    <dbReference type="OrthoDB" id="6161790at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21698">
        <property type="entry name" value="PROTEIN (PUTATIVE)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21698:SF4">
        <property type="entry name" value="PROTEIN (PUTATIVE)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1244956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="205" mass="23609" checksum="CFB12E9D2550AB0A" modified="2021-09-29" version="1">MSHDISISIFFSLSLSLILSLNLSIYLSIYLSIYLSIYLSIYLLVCLSFCLSICLSLCLSVCLSIYLSIYLSIYLTAYLSIYLSIYLSIYLLVCLSFCMSIYLSIYLSIYLSIYLSIANCSYLSICLSIYKFVCLSACLSVFLSVYLIVGLSVCLSIYLSIYLSQTVHIYLSIYLSIYIYIYIYIYIYIYMSQTIHIYLSIYLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BYP5</accession>
    <name>A0A812BYP5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_25069</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000947">
        <property type="protein sequence ID" value="CAE1246284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BYP5"/>
    <dbReference type="SMR" id="A0A812BYP5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="158"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="188"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="224"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="325"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="358"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="387"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="417"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="447"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="477"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="513"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="558"/>
            <end position="580"/>
        </location>
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        </location>
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        <location>
            <begin position="657"/>
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        <location>
            <begin position="692"/>
            <end position="710"/>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="730"/>
            <end position="754"/>
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        <location>
            <begin position="775"/>
            <end position="798"/>
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        <location>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="836"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="914"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="945"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="971"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1027"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1028"/>
            <end position="1046"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1246284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1057" mass="125106" checksum="A9039A3C8A59A298" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C1V0</accession>
    <name>A0A812C1V0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_29819</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001193">
        <property type="protein sequence ID" value="CAE1255705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C1V0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="39"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1255705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="208" mass="24150" checksum="4F661F8CA7BBD1A2" modified="2021-09-29" version="1">MFFLTFILFIFLLPNIGSFSLSFYLFSFLFFFFSSNVSFSFFCLSSLSISFNVLYFLLLLLLLLLLLLLLNVLCTYFQLLFCLMFFFLSFSSSTPFDYPLCLSFLSFILLIFPSSYYSSSSSTERFPLILILSFFLSFFLSFFLSFFLSFFAFISAVLRSYLLLVKRDACAISASTILFPPIAAMFAARISFLLEPTGNSNDTRRWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C238</accession>
    <name>A0A812C238_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_26965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="CAE1250109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C238"/>
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        <location>
            <begin position="383"/>
            <end position="406"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAE1250109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="430" mass="51531" checksum="3D15B0141D219F7A" modified="2021-09-29" version="1">MTNNISPQTSQNYHPLSSYLLSQKHKYITVGTDIFFNLPSHLYKFFYLSIYLSIYLSICLTYLFLIHIYLSIYLSIYLSIYLSHSVPYLSIYLSHSHLFNLIFSYASIFPSTFLSLPLHFFFFLFFFIISLYVSFSSHIFLSFHVSFFLLFYIPSFFFIFFLSFFLFSFFPSFFFYCFIISLYVSFLFPLLSTSLSSFLHSFFLSFFLSFFLTSLFLSTPLSFFPRLFLFHFFFFLSFSYFFLSLLLCFYISFFFFLHLPLFLLTSLSFFLSFFLSFFLSFSTKSLSFNAPFILSISFLSTSFLSIYLSFFLPASLYFHTFFRLSFVRSTFLSFFQRPFLSTSFYFHVSFFFLHFFLSFFLLSSLPSFFPSFLPSFLPSFLPSFLPSFLPFFLQLFFFPGLFLSFIRFFPHHFFSFSFFSPDGFQFNLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C2Y8</accession>
    <name>A0A812C2Y8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_28621</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001120">
        <property type="protein sequence ID" value="CAE1253816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C2Y8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="51"/>
            <end position="71"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="78"/>
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            <begin position="133"/>
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            <begin position="160"/>
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            <end position="317"/>
        </location>
    </feature>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="319" mass="36530" checksum="08FF7D965D019BB3" modified="2021-09-29" version="1">MNDNKKSSGYHEAFEGWRIGRGIHLIKRGLFGGCPQATNYLSIYLSIKECFTYSSIYLSIYLSIYLSIYLSQSYLNEFLSIYLSIYLSIYLSIYLSKHVLIYLSIYLSIYLSIYQSMFDLSIYLSISDLSKLVPIYLSIYLLSIYLSIYLSISANNISVYNYYLSIYLSIAACLDLSISACSDRSISVVHIYLSIYLSIYLSIYLSASSDLSIYLSIYLSIYLFQPLQIYRSQPVQIDLSQSVHIYLSIYLSIYLSIYQPLQIYLSISASLDLSIYLSIYLSISASSNLSISACLDRSISVCSYLSIYLSIYLSIYLCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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    <name>A0A812C307_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
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            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001123">
        <property type="protein sequence ID" value="CAE1253875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C307"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="6"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="193"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="356"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="385"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="504"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="540"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="576"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="617"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="648"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="686"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="716"/>
            <end position="740"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1253875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="767" mass="91416" checksum="B7DD22FA42E4CD91" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C9I4</accession>
    <name>A0A812C9I4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_33726</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001414">
        <property type="protein sequence ID" value="CAE1263455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C9I4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1263455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="265" mass="32269" checksum="929A8F8534F4DEFA" modified="2021-09-29" version="1">MTTFILSIYYLIYLFYLSIYLSDPIYLSIYLSIYIPFFFLKKYLLFLFKKKFINLIIFSHDSIWNKNCSLSIYLSIYLSIYLIYLPFFLNLFLFLSSFLCFFFFLSFFLSFFLSFYICSLSISLSISICSYLCIYLLQFFHYLSIYLSIYLSIYLSFFLSFFFFLCFFFFLSFFLSFFLHLFIIYLSLSLSQFVHIYISIYCNFSLIYLSIYLSIYLSILSFFLSFFFFFFYLIFLSLSISLSIYLSIYLSIYFSLFKSTIYLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CA19</accession>
    <name>A0A812CA19_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">TRAM1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SPHA_32962</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001375">
        <property type="protein sequence ID" value="CAE1261910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CA19"/>
    <dbReference type="OrthoDB" id="3053196at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045048">
        <property type="term" value="P:protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006616">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016447">
        <property type="entry name" value="Translocation_assoc_membrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12371:SF11">
        <property type="entry name" value="TRANSLOCATING CHAIN-ASSOCIATED MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12371">
        <property type="entry name" value="TRANSLOCATION ASSOCIATED MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="197"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="9">
        <location>
            <begin position="76"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAE1261910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="375" mass="43431" checksum="6853D9A27BE163E5" modified="2021-09-29" version="1">MFQVSSPIASLFVAMQHNVTVNGSDNMQFSYYTYGPKDTFAIFFYMLICVVIHAVIQEYVLDKINRKMHLSKLKHSKFNESGQLITFYAASIIWGADIIIREAYISNINALWEDYPHAEIAYWLHCFPELYFQKIKKEEIPARVLYTSLYLTTIITAYLLNFTRVALCMLVLHYTVDFVFHFARSMHFGEKQKFASNVFMVWNVLFVIVRFTIITLAFLTFWYGLEKTSQSSINFATGNFNTMLVRIICLSGVCLLQGWMMWKFINFHIVRIRERDVTASYRKSMSPKKKQAKIRDSNADFNHHNSATENGSVRSRGRGFFNIQSNLVYLSLSLSLSPPPPSCLLLPFPSPSPSCTNFLLLSNFLYLLAYTDHTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CBR5</accession>
    <name>A0A812CBR5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_31865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001323">
        <property type="protein sequence ID" value="CAE1259851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CBR5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1259851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="340" mass="36423" checksum="A8F4008A1E749E0D" modified="2021-09-29" version="1">MSHSQALWGISPAVTLVHPTHISLCPCHNLSIYLSQSVHVCLSISVCSCLSIYLDLFVSVYLSRSVRVCLSISICSCLSIYLSLFMSVYLSQSVCVYLSIYLGLFVSVCLSILVCSCLCVYLSRSVRVCVSISLSLSLLTFASLSLLTFASLSLLTFASLSLLTFVVLSLCSHLSFSLSAHICRSLSLLTFVSLSAHICLSLCLLTFVSLSLSLLTFVSLSLCSRLSLSLSAHVCLSLSLSRLSLSLSAHVCLSLCSRLSLSLCSHLSLSLSAHVCLSLSLLTFVSLSLSLSLLTLVSLSLPAHTCLSLSPCSHLSLSLPVCSHLSLKFTSQMTDSMLIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CBS5</accession>
    <name>A0A812CBS5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_31924</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001324">
        <property type="protein sequence ID" value="CAE1259870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CBS5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1259870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="266" mass="31493" checksum="E18B5A65CB355128" modified="2021-09-29" version="1">MLILSLLFLLFPLPFSFFYSIYPFLVFLFSISPSSLSLSFFLPPFPLLPLCSASLSSIFSSSSFFSVSSSFFLSFRPSLSYSTSFLQLLQSVYSTISYYYCLFILLVQFFFFFFFFFFFFFFTRVYLSLSLSLYLSIYLSIYLSIYLSHYDHIYVCMLFLYLSIYLSIYLSIYLSIYLVMFITIYAFMLYSYLSHYAPIYLSIYLSIILCSYLCIYVIIFISIYLSIYLSIYLSIYLSHYVHNYLCINIIFISISLCFDLSIYLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CD78</accession>
    <name>A0A812CD78_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_35546</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001532">
        <property type="protein sequence ID" value="CAE1267297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CD78"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34723">
        <property type="entry name" value="PROTEIN CBG17025"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1267297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="190" mass="22250" checksum="05939AAF2E586220" modified="2021-09-29" version="1">MFFLFFLFPSASSSILLPVFILLSFVCLFPSSFLPSFLPSFLFFVLIHSLHAFFQQLSFSFFFHPHCHFFLLSTHFTLFFPFFLPSLPISFLHSFLHSFLHSFLPSFLPSFIPSFLLSFLPSFIDSFLHSFVHSFHSFLHSFLHFPSFIPSFIHSFIPSFLPSFLHSFVHSFLPSFLPSFLPSFFPSFLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CEA7</accession>
    <name>A0A812CEA7_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SPHA_33237</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Farmed</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="CAHIKZ030001391">
        <property type="protein sequence ID" value="CAE1262426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CEA7"/>
    <dbReference type="OrthoDB" id="8957712at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000003">
        <property type="entry name" value="TRAF2 and NCK-interacting protein kinase isoform 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000006">
        <property type="entry name" value="TRAF2 and NCK-interacting protein kinase isoform 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051700">
        <property type="entry name" value="STE20_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47096">
        <property type="entry name" value="MISSHAPEN LIKE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47096:SF1">
        <property type="entry name" value="MISSHAPEN LIKE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="25"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="308"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="519"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="579"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="318"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="393"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="430"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="525"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="584"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAE1262426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="641" mass="72248" checksum="2A0EAD5E39530A6A" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CEH9</accession>
    <name>A0A812CEH9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_33372</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001396">
        <property type="protein sequence ID" value="CAE1262745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CEH9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="329"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="366"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="419"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="445"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1262745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="464" mass="56354" checksum="32911A528102A7EB" modified="2021-09-29" version="1">MPPAFLPSFFPFFLFFLSYFLSFFLSFFLSFLFILILCILSFYLSFFLSFFLLHLSLSLSTYNTSMYSSFFLSFSFFLHQSFFLSFTSFTFLCHLVILLLNFYVFLSFFLSFFLSLSFFLSFFFTSFPFSVHLVISFYYEFLSFFFFLSFFFTSFTFSVHFINTSLYFFLSLISFFLSFLSFFLFTSFTFSVPFNTSMYFFLFLSFFSFLSFNFFLYLFFLSLSLSISNTSMFSFFLSFFLSFFLSFFLSFTSFTFSVNLVILLCISFFLSFFLSFFLSFFYIFRFLCPLSNTSMYFFLSFFLSFFLSFFLSFFYIFHFLCPLSNTSMYFFLSFLSFFSFFLFFLSFFLLSFTFSVQISKTENVFFFFFSFLSFFFYIFSFFLCPLVILLCISFFLSFFLSFKKNFLSFYFLSLSLNTSMYFFFSFFLSFFLSFFLSFCQFTCSVDFYFYLSIYLSIYLSIYLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CFJ0</accession>
    <name>A0A812CFJ0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_35049</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001505">
        <property type="protein sequence ID" value="CAE1266190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CFJ0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23304:SF189">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23304">
        <property type="entry name" value="SPOT2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1266190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="306" mass="36365" checksum="043F7C22B41656E6" modified="2021-09-29" version="1">MLLFRLADEECYYSRWQWKNAIIPVDRGICYYSRWQRKNAIIPVGREGMLLFPLADEECYYSRWQRKNAIIPVGREGMLLFPLADEECYYSRWQRKNAIIPVGREGMLLFPLADEECYYSRWQRKNAIIPVGREGMLLFPLFISIYLSIYLSIYLSIYLFQSVHIYLSQSVHIYLSIYLSIRAKLANTASRRPIYLCIYLTVCSYLSIYLSIYLSIYLSISIYLNPFISIYLSIYLSIYLSIYFNPFIYLSIYLSIIYLSIYLSIILFQYLSYLSIYLSIYLSIYLSIHISLFILGSYLNPYRLIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CJ86</accession>
    <name>A0A812CJ86_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_40139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001891">
        <property type="protein sequence ID" value="CAE1276611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CJ86"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1276611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="304" mass="37076" checksum="3BF0E0604C801225" modified="2021-09-29" version="1">MYIPHSDYYLSLPVAVDRSLVMTLVVTDFLSFFLSFFLSFFLSFFLHHLCLLIFFLSFFFFLSFFLFFFLLIFVSIEFHLSFFLTFFLSFFLSFFLSFFFRFIFLSFFLSFFLSFFLSFYSNYYFSRPFFLFCFLFSILLSFFLLFFLYFYFFLCSLLFFVFSFFLFPFLFSFSILFSSFSLFISIFLLFFLFSCLFSRLFFSFSLFSPVFIFFPFFLFSSFSTFFYFFSPFSFFSFPFSFFPLFSLFLHISLFSFFFFLLLPPSPFLFFVKTCVARSGNSTYVCLVIYLSIYLSIYLSIYLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CK10</accession>
    <name>A0A812CK10_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_37414</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001668">
        <property type="protein sequence ID" value="CAE1271790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CK10"/>
    <dbReference type="OrthoDB" id="6161790at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1271790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="214" mass="25892" checksum="3A41C7D8C66C620D" modified="2021-09-29" version="1">MPGAYFSLIKLFCFFNNSLFFFLSFSFFFFLLFLSFFCHCYLSICLSIYLNLFISISLSESVNIYLYIYLLQSVHYLSICSYLSQFAYIYVSIYIQIVHLSIYLSIYLSIYLWAESPRCRNIDTRNHYDSFFDRNYNDGRARDVFERITSVPDRNEYEQVRIESREMDFRREYLSWTEVSASKERDKKTRFVQEIHYNITLVRLSRLSSIVINF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CLQ3</accession>
    <name>A0A812CLQ3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_39508</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001839">
        <property type="protein sequence ID" value="CAE1275527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CLQ3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1275527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="266" mass="31888" checksum="82437DA1C5F2C8E9" modified="2021-09-29" version="1">MYLSIYLSIYLSQTVLSIYLSIYLSIYLSIYLSIYLSKFLSDLSISIYSLCIYLSQSVHYLFIYFLQLFIFSLSLSFSLSLSFSLSLSLSPHRSHSWKLLIYLSIYLSIYLSISHHTANTSLFLSTYSIYLSFFLSIYIYLYFFFQSIYLFLSFYISFYLSSFFLSIYLFIYIYIYISFFHFISSLTQSICFLLIPTCSVNFSIMFIDKFDYLEIYGHSLAAISFFPHFFLSIQISFFFLCFFFLSFFFSFFFFYPFYLSIYLLKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CS32</accession>
    <name>A0A812CS32_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_42390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002073">
        <property type="protein sequence ID" value="CAE1280584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CS32"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1280584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="225" mass="26914" checksum="F2B182B943249500" modified="2021-09-29" version="1">MYHPPSYISIFFCHIYLSSSVISIYLRLSYLSDYIRLSYLSIFVYHICLFIFVCHIYVSLSLIYIYPRLSYLSIFLSHVYLSIFICHIDLSMDLRRLSTHILSVQYLILFIHSSIYLSISVHYLSIYLSIYLFIYHIYLSIYHLSIIICFIIIYHLSIYLSISSIYPILFIIHLFIHPILFIIYLSILSIYLSIYHLSNSVHYLSIYLILFIIYLSIYLSIYLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CSB6</accession>
    <name>A0A812CSB6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_43920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002224">
        <property type="protein sequence ID" value="CAE1283196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CSB6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1283196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="180" mass="21291" checksum="0B5311E6B445F7DB" modified="2021-09-29" version="1">MLQHLSKYKNLFESAFGIVPNTPAITSTTLSIKLPFSIYLFLSFFLSFFLSFFLSVFFFLLFSFFFTVIYIQCFLIFTFHFYWLFIATYFHAFVHIFFFYLCFFFFCIFYYFLNLSKTLFSLSHSLSLSLSLSLSLSLSLSLSLSLNEQYTLSLFIKLDFLSLSQIISLSMYFVFLSLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CVI5</accession>
    <name>A0A812CVI5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_45623</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002357">
        <property type="protein sequence ID" value="CAE1285786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CVI5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134:SF22">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134">
        <property type="entry name" value="OS08G0543275 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1285786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="280" mass="33516" checksum="7062BC3FA41C76E3" modified="2021-09-29" version="1">MCSVVICILTKLFYLSIYLSIYLSIYLNTFIIYLSIYLSIYLSICLSVCLSVCLSIYLSVCLSVCMSVCLSISIRSLSICLSIYLSIYLSMFIIYLYIYLSQYDHYQSIDRSIYLNMFIIYLSIYIYIHTYIYTYIYQFVIIYLSIYLSIYRSIYLNIYLSQYVHYLSLFLSLSLSLSLYIYIYIYIYIYIYIFQYLFIYLSIYLCSYSSMYLSIYLSIYLSLFISIYLSIYLSIYLKLFLTIYLSIYISINLSLFISIYLFETVHIYLSIYLSIGVEEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CVN3</accession>
    <name>A0A812CVN3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_42826</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002112">
        <property type="protein sequence ID" value="CAE1281324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CVN3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1281324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="224" mass="25644" checksum="818E782F6B932819" modified="2021-09-29" version="1">MRLVFQASIRNASSKLNPSVLMSKTPFFRSFPLSIYVVVLHIYLSIYLSIYLSIYLSIYLSLFRSIIYLSIYLSIYLSIYIYNLSIYLSIYLSIYLSIYLSISVYSDLSIYLSIYLSIYLSIYLSLCLSFCLSQSDPSFLSVYLSLFLPICLSISVSFSLSFFLSIYLSQSLHISLSVPIYMIFSFALLHLTFLPFPEFHITETGTLPLSLSLSLSLSVHHSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CWA1</accession>
    <name>A0A812CWA1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_41389</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001984">
        <property type="protein sequence ID" value="CAE1278656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CWA1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="491"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1278656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="515" mass="56204" checksum="0ACC6CF1F0254094" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D154</accession>
    <name>A0A812D154_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_47462</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002573">
        <property type="protein sequence ID" value="CAE1289070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D154"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1289070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="318" mass="37752" checksum="C6615F51575E0D2D" modified="2021-09-29" version="1">MLLVLILNKYPSIHLSLSLSLSLSLSIAIFTLSVSLYLPFLSFLSLFFSIRTLLIILHLLFELQLPLLLSLRFYFDLLLFSSTLSSLVVVVVVVFFLLLLLLRLNFFFFSSSSLFFVRDFFFFFFFFFFFFRSSHLPPSIFFSNFPSPPSSSDPPPPFPFLVVFSFSSAFIFFSNFIHFSSSFFYFFSYSPPTSYFLFSNFFSSSTFFFFFFFFFFFFFFFFFFISEFLLLSELLFRTSSHFPSLRFEHLLQLFSPILLNNNNNKKKSFCSRKSKLQRPLRFVCKKKSIKMFKETDLVQELAHKNNGIKYLSIKFTNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D2R5</accession>
    <name>A0A812D2R5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_48261</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002667">
        <property type="protein sequence ID" value="CAE1290557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D2R5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1290557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="300" mass="36116" checksum="86CD1BE272E4C505" modified="2021-09-29" version="1">MNSRTYRGLSRCLSGHLTQSVHIYLSIYLSIYLSIYLSIYLSLSVYSYLSIYHSIYLSIYLSIYLSIYLSQSIHIYLSISVYSYLSIYLSIYLSIYLSQSIHIYLSIYLSIYLSIYLSLFISIYLSIYLSIYLSIYLSTQMSVQYISIYLIYLSQFIYLSIYLSIYLSIYLIISIYKKYYFLFVFFFPLDSFFLFLPFFLYVAYTLSFIFFLFFFLSFHHRYICFLFCFLCFFSTSVCFFFVPSFCLTNNLSFFLSFFLSFFLSFFLSFFISFFVPLIFLSFFLSFFLSFFLSFFLSLSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D5E9</accession>
    <name>A0A812D5E9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_50160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002933">
        <property type="protein sequence ID" value="CAE1294152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D5E9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1294152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="231" mass="27108" checksum="BE46EB3621E0905C" modified="2021-09-29" version="1">MSSRRKERLSKYFSCNVYTSAKILSRFLAFIQAYFTKDYLSIYLSIYLSISVTPFIFIYLFSYRSIDLCSSSNFNKGETCYKLLSPFSYPIISIYFSLSLSLSLSLSLSLSVIHLYLSIYSSISFDTFLSKYLSIYLSISFDIYLSLFLSIYVEPFISIYLSIYLIYVFLCFYLSIYLCWSIHIYLSIYLSISFDICLSLFLPVNLFMLVYSHLSIYLSIYLSIYLSNYLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D5X1</accession>
    <name>A0A812D5X1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_47164</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002545">
        <property type="protein sequence ID" value="CAE1288534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D5X1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="13"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1288534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="242" mass="28432" checksum="38F6CC933BE28066" modified="2021-09-29" version="1">MYLSIYLSIYLSIYLWTECLFSIYLSIYLVLLFIYLSIYSFIYLSIYLVLLFIYLSIYLSQSVHYLLLFSIYLSLFTIYLSISVSSLSIYLSQFLHYLSIYLSFFTIYLSIYQSQSLHYLSIYLSIYLSFFTIYLSISVSSLSIYLSQFLHYLSIYLSISVSSLSIYLSISVSSLSIYLSISVSSLSIYLSIYLSQFLHYLSIYLSISVSSLSIYLSQFLHYLSIYLSFFTIYLSIYCFLSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D813</accession>
    <name>A0A812D813_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_51523</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003120">
        <property type="protein sequence ID" value="CAE1296544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D813"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="359"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="409"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="431"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1296544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="454" mass="54715" checksum="F812FA23A0EF9D9A" modified="2021-09-29" version="1">MKLYFFFFLSFHFSFLFFLFSFLPSFFISFHFSFLFFHFSFFSFFLSFLSFFLFSFSFLFLFFIFYFSLCFIFSVFLSFQIFFLSFFLSFFFFLFLFFFLFTPSFSSLHFSRFFLLQFSFSFFLSFFFLFSFFLFSFLFRVLHFLFSSSSLSLFLTTPSFLCLSPTPLFLSPFFLLFSPSVFFLSFFLSFFLSFFLSFFLLFPSLAFSIFFFFSLSFSLHTLFSLSFSHSPFSSLHFSRFSLLQFSFLLFFFTFLFSILSCFVFFFVFQHFQFLSFFISFHFILSPLTLLSFFFITSDIFSFSPSSRLLYLYISFSLLFSYLNTSNFFLSFTIQLSIFLLVSVFIRISTQISYSEHTYTCTYLSIYLSIYLSSLFISIYQPEFVYFYLSVYLSIYLSGIVHFHLSISGFHIYLSIYLSIYLSIYLSEFVHFYLSISGFHIYLSIYLSIYLSISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D9L6</accession>
    <name>A0A812D9L6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_48666</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002722">
        <property type="protein sequence ID" value="CAE1291223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D9L6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1291223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="239" mass="27856" checksum="8C2A95D2FB0397DF" modified="2021-09-29" version="1">MQNRIKAQRGSDVKDFPGDPGLCLYNKEVLNVCCGTCNLSIYLSKSFHYLSIYLSIYPNLFIIYLSVTVFSLSIYLSIYVSIYLSQSFHYLSIYLSIYLSIYLSIYLSSYLNVCHGTFNLSIYLSIYLSIYPSLFIICLSIYLSKSFHYLSIYLSIYLSIQVFSLSIYLSIYLSIYLSIYLSKSFHYLSIYLSIYLSIYLSIQVFSLSIYPNLFIIYLSIYLSIYPSLFIIYLSIQIFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DGE0</accession>
    <name>A0A812DGE0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_53667</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003431">
        <property type="protein sequence ID" value="CAE1300166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DGE0"/>
    <dbReference type="OrthoDB" id="9635126at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134:SF22">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134">
        <property type="entry name" value="OS08G0543275 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="295"/>
        </location>
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            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="508"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="534"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1300166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="562" mass="68702" checksum="1D9A28A3979C8980" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DGS5</accession>
    <name>A0A812DGS5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_53456</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003402">
        <property type="protein sequence ID" value="CAE1299755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DGS5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1299755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="309" mass="36398" checksum="7A64BFD7A030EF48" modified="2021-09-29" version="1">MFLHLCETIYYFHVNLSIYLYGNLCSFGTIYIHVKQSIYLSSCESMSLYSCETVYLLSSCETIYLSIYLSIYLSIYLSIYLHGNLCSFGTIYVHVKQSIYLYSYETIYLLSSCVTIYLSIYLHRNLCSFGTIYVHVKQSIYLYSYETIYLLSSCVTIYLSIYLSIYLSSRESMFIWNYLYPLCLYIHVKQSIYFLHVKQSIYLSIYLSIYLHGNLCSFGTIYVHVKQSIYLYSYETIYLLSSCVTIYLSIYLHRNLCSFGTIYVHVKQSIYLYSYETIYLLSSCVTIYLSIYLSIFTGIYVHLELSNSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DIA0</accession>
    <name>A0A812DIA0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_53535</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003413">
        <property type="protein sequence ID" value="CAE1299935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DIA0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1299935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="169" mass="19539" checksum="572646D510662245" modified="2021-09-29" version="1">MCHPPCCLPILNFIYYDVLSDSSMCHPPFCLPLNFIYYDRLLDYSMCHPPFCLPLNFIYYDLLSDSSMWIPPCCLPLNCIHYDLLSDSSICRPPYCLPFNFIYYDLVSDSSMCHPPCCLPLNFIYYDLLSDSSMCHPPWCLPLNLILFSDYDLCLPDSIHVPSSMIPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DK14</accession>
    <name>A0A812DK14_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_55118</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003642">
        <property type="protein sequence ID" value="CAE1302599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DK14"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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            <end position="58"/>
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        <location>
            <begin position="258"/>
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        </location>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1302599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="285" mass="33370" checksum="FE2625E243A25153" modified="2021-09-29" version="1">MLCLEDGRLKLAAIANLTSCQKIKALYKTNRKRKIGFVCLSSFSFFFFYPFLFFASPLPSPPPLLLLLLLSPSFSSPSPPLLFFLTYFSPSPSLSFLFPPPFSSRASFPRPPIKTQERRLNIFSNFFIHLFFIHFFFIPLFFIHFFFFLFYRSFILHSLFLHSLFLHSLLLNSYILHSIFFVLFFLSSFFFKFLRPIHRNVLPFHSPPFSSYFFAVVFSFLSFPFHTMTVTFDTTLITNNTIAAARASDQLLFAFLKYPYSCIFLYSAQLLMTIIMEEAYVTHAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DKJ5</accession>
    <name>A0A812DKJ5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_53962</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003453">
        <property type="protein sequence ID" value="CAE1300633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DKJ5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    </feature>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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    <feature type="transmembrane region" description="Helical" evidence="1">
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    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="337"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="373"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="410"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="604"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="633"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="672"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="703"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1300633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="725" mass="84474" checksum="5E8B6D4BDAA74D87" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DLU7</accession>
    <name>A0A812DLU7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_59037</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004081">
        <property type="protein sequence ID" value="CAE1306909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DLU7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="325"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="386"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="416"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="444"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="471"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="500"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="536"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1306909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="583" mass="68845" checksum="9A8DFE4600C40A23" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DNS9</accession>
    <name>A0A812DNS9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_57777</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003908">
        <property type="protein sequence ID" value="CAE1305273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DNS9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1305273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="210" mass="25053" checksum="88ECCB6A16FF036B" modified="2021-09-29" version="1">MPRSRKLIIAFLVRNLSIVFNFASFLYVFLSFFLSFFLSFLTLCHSLTFFPGLFHFLFFGAIRKCGSLYTRQSTRNINGAVDNLSIYLSIYLSIYLSIYLIMFIYQDDYLCSSIYLSIYLSIYLSIYLSIYLIMFIYQDDYLCLYIKMTITICSSIYLYLSIYLSIYLSIYQDDYLCLYIKITITICSSIYLSIYLIMFIYQDDYFYISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DPV7</accession>
    <name>A0A812DPV7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ETNK</fullName>
            <ecNumber evidence="2">2.7.1.82</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_57620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.82" evidence="2"/>
    <dbReference type="EMBL" id="CAHIKZ030003891">
        <property type="protein sequence ID" value="CAE1305139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DPV7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004305">
        <property type="term" value="F:ethanolamine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="48"/>
            <end position="76"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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    <feature type="transmembrane region" description="Helical" evidence="1">
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    <feature type="transmembrane region" description="Helical" evidence="1">
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1305139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="389" mass="43895" checksum="5755183E66B1E7F1" modified="2021-09-29" version="1">MFDPMKSLRNFSLFRLLSLSLPSSLSLFPSLSLFPLFSFSLSLPSSLFFFSLSLSLPSSLFFVLSLSSFLSLFRFLSLSLSLPSSPPLSVVFALSLFSFLSSSLFFVFSLSLFLPLLHSVVFALSLSLFLPLSFSFSLSLSLFLPLSFSFSLSLSSSPPLVFSISRCRHHYVCFILSLLSGMPFNFSFFFSLNYFFTFFSNFSIFSSPFFPFRPLFLTLRFIAFLNYLSFHYQAFEIGFGESNYTFYLSLSLSLYLSIYLSISLSLSLSLSLSLSIYLSISLPLSLSLSLSIYLSIYLLPLSFFLSLSLSLSIYLSISFPLSLSLSIYLSIYLIPSLSLSIYLSISLPLSLSLSLSIYLSIYLTPSLFLSLSLSLSIYIYIYIYIYIYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DQN2</accession>
    <name>A0A812DQN2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_56865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003794">
        <property type="protein sequence ID" value="CAE1304151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DQN2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        </location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="519"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="549"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1304151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="572" mass="70445" checksum="DD2DAA4D58E2F2E2" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DR85</accession>
    <name>A0A812DR85_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_58851</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004049">
        <property type="protein sequence ID" value="CAE1306600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DR85"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="303"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="338"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="390"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="414"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="438"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="477"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1306600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="525" mass="62925" checksum="5C2CF419E79E0409" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DS82</accession>
    <name>A0A812DS82_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_58924</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004069">
        <property type="protein sequence ID" value="CAE1306756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DS82"/>
    <dbReference type="OrthoDB" id="6142245at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000100">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF7">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1306756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="177" mass="20236" checksum="B875363C00441862" modified="2021-09-29" version="1">MRCHHKTPTMKEFSHKLSGTKFFSKLGAKNGYWSVKLDRESQLLTTFNSPFGRYCFRRMPFGLVMSQDVFQQRMHMIIEKCTGALALIDDVIIHGKTKEEHDLNLRKLMETARTAGLTFNSSKCAIDHEQVKFFGAIFDRNGIHPDPQKVEEKKSLPSPRNITELQKVLGIIGAIHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DT76</accession>
    <name>A0A812DT76_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_61901</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004391">
        <property type="protein sequence ID" value="CAE1310287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DT76"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="124"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1310287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="210" mass="24612" checksum="1A6FC60097137DBC" modified="2021-09-29" version="1">MSSSLSSSFSSSSSSSSSSSSSSSSSSTLPLLPYLNFILILFSSFFFHLKIFFLLLILLFLLFLLLLPAKILSPILLLLLPLLLPPILFHFLHLLFFLIFFFLFFSFLFFLSFFFHLTPFFLPFYFLLLFFFFLLLFFFFVLFSFFSFNILLFFLFLLSFNYNSYRSYGLLQKICHLVSSFFSSSERVNFLRPLPSSFLPFLLFSSVILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DUQ4</accession>
    <name>A0A812DUQ4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_61156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004302">
        <property type="protein sequence ID" value="CAE1309446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DUQ4"/>
    <dbReference type="OrthoDB" id="10030815at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1309446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="226" mass="25494" checksum="B36DE3D15A874479" modified="2021-09-29" version="1">MLTGPSEEPQNISDPRKTAVINGELKRLHVDIASQQETQRNEPRQHGVDFAVRNSLLNTIEQGSNVSDETPPSPTQHHRRPGHHRVDEFYDKLAATIICIPSKNQLVLLGDSTPVWVLIMTLSLGQFGVGKIYENGQTILELCIYHNLRTANSFFRTKTKHKVSWTPPHSKHWHQLDLILVRRAAIKTVLYTRSHWCAAISNTSPRVSTAVRSRGILALMSVCQEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DWN7</accession>
    <name>A0A812DWN7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_63768</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004577">
        <property type="protein sequence ID" value="CAE1312540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DWN7"/>
    <dbReference type="OrthoDB" id="6819399at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1312540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="220" mass="25850" checksum="8F6FDB5A80CFFD89" modified="2021-09-29" version="1">MARGTRTVYPTYSFFLSFFLSKSITFFCLPQSLHYLSIYLSVYLSVYLSIYLSLFIVYLLKIIIKNFPAIPFYSVSFILLSIHFILLFFILFLSIYLSIYLSIYLSQSVHIYLSIYLSIYLSQSVNIYLSIYLSQSVHIYLSQSVNIYLSHSIHIYLRQSIHIYLPIYLSISVCSYLSIYLSIYLSILFSSYISIYLFQSVHIYLSIIKKNPAMPFIQTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E4K3</accession>
    <name>A0A812E4K3_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Band 7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SPHA_67946</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004929">
        <property type="protein sequence ID" value="CAE1317382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E4K3"/>
    <dbReference type="OrthoDB" id="5986675at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="51"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Band 7" evidence="4">
        <location>
            <begin position="91"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="278"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAE1317382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="344" mass="38851" checksum="8462983DB2B08DF6" modified="2021-09-29" version="1">MSSSPSREPEEVQLELQPSGDGTTTHAKQNLQMADLEGCCPDLKDSNNKMIAICIGVLFIIGLMLLIIILPLSFSYLDYYEFGVVRNKITASVNLDKVYDSGRYVIGPSHEFKTFQADAHFQSVNNIRVFTSDKLEVGLSAWYQYFLVQNELPYLHKKYDIYYHDKVKRKGNDAIKNVVTRFTTRDVVKQRLLLETELYQNLKNVLGGDCCEAYCERDQNATGCVSCKPRNNCTIENYGMFVDVRYFQLGAIDIPDALDESFLNALILNASAEREGFIQEAHIVRKETEQKVKQIENLAAETLQAAQSDSRVISDTAKANANLLDFLLVSLKLLYSHPNPSLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E4K8</accession>
    <name>A0A812E4K8_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SPHA_66192</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004770">
        <property type="protein sequence ID" value="CAE1315191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E4K8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51225">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="298"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="359"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="389"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="7">
        <location>
            <begin position="124"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAE1315191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="478" mass="59798" checksum="3A46854056F95052" modified="2021-09-29" version="1">MYSLFSFMCRRQCLCQQNRYEILSPYCPFLLRSFLSFLYNFPFLLYFFISFFFFPLTFFFFIFLTLLFFLFKFNYPHFLFSFLSFSSPFFICFFLPLSSFTISLFLFLSFLSFFLSFFFFLFFFFFSKIHFVFLFSSKFSFICFFCLLSYLLFRYFSFSFLSFCFFLSFFSFFFLPFLLIIYFLYILLFLFSFFLFFFLPSFFTISLFLFLSFSFFLFFYLFFFLPSVLIYYFAISLSFFFFLSVSFFLSFSFFLFFLFLQNSLFISYIILHYSFSISFYLFFFAFCPHLLFRYFSFFLFLSFCFFLSFFFFLPFFLSFFFFLPFFLFLQNSLFICYIILHSSFSFNFYLFFAFCDHLLFSLFLFLSFPFFLFVCFFLSFFPFSLFYKVYYTFIFLRLSYFIFFMFFLPFPHVLIITFCFFYFFYLFILFFLSLFLFIFNFCFLGFPKFFFSTFTLSWLHLPRRIPRPILIIFKTSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E682</accession>
    <name>A0A812E682_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SPHA_65095</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004686">
        <property type="protein sequence ID" value="CAE1314090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
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            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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            <begin position="87"/>
            <end position="120"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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            <end position="537"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="5">
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    <feature type="transmembrane region" description="Helical" evidence="5">
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    <feature type="transmembrane region" description="Helical" evidence="5">
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    <feature type="transmembrane region" description="Helical" evidence="5">
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        </location>
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            <end position="2062"/>
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        <location>
            <begin position="785"/>
            <end position="1031"/>
        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAE1314090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="2113" mass="245068" checksum="9F145A6944BEEF20" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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    <name>A0A812E6B6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_67140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Lophotrochozoa</taxon>
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            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
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            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E6B6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
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        <location>
            <begin position="6"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        </location>
    </feature>
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        <location>
            <begin position="60"/>
            <end position="87"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="158"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1316422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="160" mass="20453" checksum="E1A69A428BDBF524" modified="2021-09-29" version="1">MIFFLFVSFILLFFCFFFLFCLLFFFLLFFLLLFYFFLLFSFFFLTFLLFFILSSSFPRIFLHFFLIFFWFFLRLSVCFSSSFFFIFKESKRERAKKKREKNNLFRLFFDLSFFFFFSFCSSFFSSLFLLFFSFFFIYFSFSFFFFLYSYSFFFRFCFTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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    <name>A0A812E6N4_ACAPH</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
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    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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            <begin position="147"/>
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        </location>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="180" mass="21176" checksum="271E643A60500423" modified="2021-09-29" version="1">MTSGKARIHPSYKHMQNNPSLRLLVRSLLGSSTTIFVTDFFLPNKFYLSFFFFLSFFLSFFLSNLCLSIFFLSSFHFFPFLSFFLSFVLSFFYVFSPFFLGYQSFFLSFFLSFFLSLLPIFLSFFLSFFLSTFSLSICPFPPSFYHSFCLVTILSAAFIPSSPLFLFVVFYRIFSTHLYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E7E5</accession>
    <name>A0A812E7E5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
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        <name type="common">Pharaoh cuttlefish</name>
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        <dbReference type="NCBI Taxonomy" id="158019"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">Farmed</strain>
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    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1319430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="342" mass="40504" checksum="8F2C7A0AAEB393F6" modified="2021-09-29" version="1">MPTVNADCCLPDSFSSSPIDSILSLFFFLVQFYFPKYFLSSLATFSLKLFLDDLPTVMFFWSTHLPNMATPHPRQMLSDYSFHIFYYIFFYISIKQMLPSFFYSGRQLNSYNLLMNPILLYFSSFFFNFTFRSIFFLLWLLFSLKLFLDDLPTVITFFVFLFINFKIPISTFFFIFFFLSLFSFLSLIFFSCILLSFEVFLSFVLTPPHLFNFSFSKIFPSDISSYFHLFLLLVISFKILSIYLSIFYLSWSLHICMSLLVTSYLSIYLSISLLFFHIFSQGSFLGRGGFFFFFLQHYFLSNVSFWQARESAFKYLLSNKYLLGQKTIASPVLKSKQIGPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EB05</accession>
    <name>A0A812EB05_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_71104</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
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            <taxon>Acanthosepion</taxon>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
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                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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            <begin position="69"/>
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            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1320919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="243" mass="28347" checksum="63AED63F548AF3CE" modified="2021-09-29" version="1">MGTHPPPFSKVVYFSYHLLSLTSPLPSANQLLTPQFYSSYSFLCSEKTQSRPNLNLKAEPRTTTFKSTVVTIALSCFLFFSFFFLSFFLSFFLSFFLSFLSLFLSFFLSFSFFLFFLSSTFLPLDVFIFTSLSFFLSFFLSFFLSFFLSLSFSFFSFFFVSFFLSFFLSFFLSFFRFSYLYLSRFNFTSLSFFLSFFLSHRRFKKIKFKLFTIFHTTSPISGHSLSLSLSLSLSLSLSLGTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EB48</accession>
    <name>A0A812EB48_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_71823</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005269">
        <property type="protein sequence ID" value="CAE1321786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EB48"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="416"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="446"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="485"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="518"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="543"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="596"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="622"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1321786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="646" mass="76736" checksum="70D2DF5FF5A1217A" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EF56</accession>
    <name>A0A812EF56_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_72487</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005327">
        <property type="protein sequence ID" value="CAE1322522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EF56"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1322522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="168" mass="19336" checksum="F761278037CA8DF0" modified="2021-09-29" version="1">MCLMSQWKENACCCIRRKSIDILLITIYLSIYLSIYLSIYLSIYHVHIYLSVMFISIYLSIYLCHVHIYLSIYLSIYLSIYLSIYLSISAMFITIYLSLYLSLSIYIYISCDSIILSASTSPTFGFSFHFVNAFAAGYSGRHGGFNAQSTRKFSLLFRHFAIDDVQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EGS6</accession>
    <name>A0A812EGS6_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA helicase Pif1-like 2B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_73363</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005375">
        <property type="protein sequence ID" value="CAE1323484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EGS6"/>
    <dbReference type="OrthoDB" id="6265497at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049163">
        <property type="entry name" value="Pif1-like_2B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492:SF57">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21530">
        <property type="entry name" value="Pif1_2B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like 2B" evidence="1">
        <location>
            <begin position="116"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1323484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="152" mass="16608" checksum="1D5C1AC0887A5008" modified="2021-09-29" version="1">MKAKLFSDSLADDLSKVILAIGDSTAPSDTAGETSVSHVVTPVDTLDDPTAAIFPDLHTNCNNLIWLCERAILTPKSIFIAKINDDLLRNVPRHLHTKKSADTVVDSEEAVHYPTEVLKSLDLSGLPPNQLHLQIGDTVMLLRNLEPSRLYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EJA3</accession>
    <name>A0A812EJA3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_74837</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005440">
        <property type="protein sequence ID" value="CAE1325176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EJA3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1325176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="319" mass="39113" checksum="C8AB6B5F69AFCAAB" modified="2021-09-29" version="1">MYFTLSLLLGSCLHFSSNHCPCLSFLFFICFFLSFFLFLSFILSFLSFLFNCSFLSYIFYLLLSSFHSFFIFFLSFLSFFSFFLFICYFLAFIYFYFLLSFIYLLFLASFFFSYYFHSFFHSCFFFSYFFLSFFLSFFSFFNWFFISFVLFFLYFGVFLSFFCFYFFFLSFFISFFVLALTLLLLSFLPSFFLSFLFSFNSLFILITVCFLSFCLFLFFPSFFCFCLLLSFFLSFFVFGLMLLFLSFFHSFFRCIFFPSFFLSSFLFSFLFFFLSFFLSFFLCIRIDIAFTFFPSFFSFFFSFLSFVLSFFCFFSLYLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ELA1</accession>
    <name>A0A812ELA1_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thromboxane A2 receptor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Prostanoid TP receptor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SPHA_77926</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005526">
        <property type="protein sequence ID" value="CAE1328383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ELA1"/>
    <dbReference type="OrthoDB" id="5959154at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004960">
        <property type="term" value="F:thromboxane receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007204">
        <property type="term" value="P:positive regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008365">
        <property type="entry name" value="Prostanoid_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001105">
        <property type="entry name" value="Thbox_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11866">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR FAMILY 1 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11866:SF16">
        <property type="entry name" value="PROSTAGLANDIN E2 RECEPTOR EP4 SUBTYPE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00429">
        <property type="entry name" value="THROMBOXANER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="90"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="1"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAE1328383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="339" mass="39305" checksum="E974D8F81667365F" modified="2021-09-29" version="1">MLHGFLMVFFGLITPLLICVLSIERLLSLKFTYFYHRLVTARKAKLTILMCWLIVMIFCSFPLMGFGRYSLQFPCTWCFLKFHRKPNASISVYAVLFGFLNLILIAIMVVCNVVVASTLLHMRRQRKINSSPSSSIKKITPSTPPPLVLPPKLKIEMEIKMVWFLSCITIFFLGCWVPFNVNILQSQLSGKIQLDRDLITVRLASINQIIDPWLYILLRGNIVRKLFNYIKSLFPYKGRRMREVQRKGIKINFPKENLDMKKTPKSTKEESHYNLPVSKQEPEEIGPCALQDPSVCYSITDDNVPAKKSSNHNNNNRETIKSKFFSRLIHIGWFHIVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ELV4</accession>
    <name>A0A812ELV4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_78231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005532">
        <property type="protein sequence ID" value="CAE1328566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ELV4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="343"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="377"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1328566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="407" mass="48580" checksum="0FB75D1A01F2301F" modified="2021-09-29" version="1">MSNNSFFLSFFLSFSTFFLSFFSTFFLSFFLSFFLFFLLYFLSFFLFSFFLLRVGKINFSFFYLSIYLSIYLSIIDVFIFIISHSSVSTRSLSFFLSFFLSFFLLYSVFCVPFFYCIPFLNCFSSHSYEFFFLSFFLSFFLSSVFIYCIPFLNCFSSHSYEFFFLSFFLSFFLSFFLLYSVYCVPFLNCFSSHFYEFFFLSFFLSFFLSFFLLSFFLSSVFSLLCSLFELFFFPFLRIFLSFFLSFFLSFFLVCLFVCFFLSFFLSFFLSFFLSFLVSIYLSIYLSIYLSILSFYLSIYLSIYLSIYLSFLFISVCLSVCRSLSIYIYACLYLSQPLNRLQCLIFSTCLSPTFLLIFLLGIRHFLFHLKGDCTSVDAIVLIFVDIVSLQPCFFASCIQNLVHPYNLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EP33</accession>
    <name>A0A812EP33_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SPHA_78397</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005538">
        <property type="protein sequence ID" value="CAE1328782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EP33"/>
    <dbReference type="OrthoDB" id="412155at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06263">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000998">
        <property type="entry name" value="MAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051560">
        <property type="entry name" value="MAM_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23282">
        <property type="entry name" value="APICAL ENDOSOMAL GLYCOPROTEIN PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23282:SF101">
        <property type="entry name" value="MAM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00629">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50060">
        <property type="entry name" value="MAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRCR" evidence="4">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="3">
        <location>
            <begin position="61"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAE1328782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="156" mass="17023" checksum="FFE32E0F51F6A932" modified="2021-09-29" version="1">MPVIGGSGNIFLADVECNGTEGSILRCDHNNFEHNDCQHESDVGVNCEETSDEITMSNSVGDCSFEYGSCGYTNQGNSSFKWEREYGSTPSGWTGPSTDHTHGTTSGYYMYTEASSGDYGDKTYLASPISNYSPLSVSFWYHMYGSDMGTLNVKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EPH3</accession>
    <name>A0A812EPH3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_78593</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005544">
        <property type="protein sequence ID" value="CAE1328995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EPH3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="319"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="358"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="388"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="413"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="437"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="460"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="493"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="524"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1328995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="561" mass="66403" checksum="DB6A706A7E7C12AA" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ER50</accession>
    <name>A0A812ER50_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WHSC1</fullName>
            <ecNumber evidence="3">2.1.1.357</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_77048</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.357" evidence="3"/>
    <dbReference type="EMBL" id="CAHIKZ030005502">
        <property type="protein sequence ID" value="CAE1327584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ER50"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140954">
        <property type="term" value="F:histone H3K36 dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032915566" evidence="2">
        <location>
            <begin position="20"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="282"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1327584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="359" mass="39712" checksum="96750C93C69B5063" modified="2021-09-29" version="1">MYLLQFSLSLSLSLSLSLSLSLSNFCINPNSFCLSHQDLPQFSLYLYLSLTSVFTPILSLTFVFSQFCLSLSLSLSLSLSLTSVFIPILSLSQSLSHSILFTPILSLSLYHTLSLKLLYSSQFSLSLLPNFCIYCNSLSLSLSLSLSLSLSLTSNLHQFSLNVSLSLTVTILSLSLTSVFIHILSFSHSLYLSLYLYCSNFYIHRSSISLSLSNFCIQPNSLSLSLFLSLSVTSYLPEFSLYLYHTLSLKPLYSSQFSLSHLTSAFTVILSPSNFCIHPNFLSLFLSLSLTSVFTSNLSLPLTSVFIQIFSLSLSLSLSLSLTAVFISILSFSISHSHSLYFYPSLSLSLLLAQTVSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ERS8</accession>
    <name>A0A812ERS8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_78411</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005539">
        <property type="protein sequence ID" value="CAE1328792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ERS8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1328792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="188" mass="21117" checksum="96806E11DF9A6C63" modified="2021-09-29" version="1">MVPGFHVQTREQIEKQQFLLLLSTLILCNFSHYLPPSIFLIFSILSLSLSLSLSLSLSLSIDPKISTNKTSLILSLSLFSFFLSFFLSLSHSLLFLSNPLSPSLFSLSLTVCLSLFLSLAPLSHSFSLSLSFLFSFSLSLSFYLSHPLSLLHQVIFPFSICNPDCKRDMLFVDGIEKITFFFFSSLAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ERY1</accession>
    <name>A0A812ERY1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_77593</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005519">
        <property type="protein sequence ID" value="CAE1328056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ERY1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="314"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="359"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="393"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="424"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="454"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="481"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1328056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="501" mass="57824" checksum="15D66B193B82D28E" modified="2021-09-29" version="1">MYLSIYVHIILFISIYLFHSSYSQILALRDSSALTRSLASQITRRFFLVTNCDISSSFLSFFLSFLHSFLDLIFFLSFFHSLIHSSFFPSFLPSFFLSFSISLSLCLSFFHSLVRFSSFFFFLSLFFVIFYLYQISLSFFLSFFLSFVLSFIRSVLISIYLSIYLSIYLYIYLILFKSISFCSNLSQCVHIYLSIYLSIYLSISVCSNLSHFVQIYLSVFISIYLSIYLSLFKSISFCSNLSQCVNIYLFIYLSIYFTFYSYLSSSQYNDHFKAEFLADNDTAFRVHSYLSIYLSIYLSVCLSVRLSVCPCQYLASYLSLSIPSLSLSLSLSLYLSIYLSLPIAGNPPLSLSLSLSLSLSIYLSIYLSIYTSICVPANIYLSVSFTCSLSLSLSLSLSLSIYLSIYLILFLTICLSIYLYCSRFGLFISALVFLSFCLSILFTSKSVYISQNILILSSFHIYLFILFSFHLSIYLSIYLSIYLSISLSLSLYIYIYIYIYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ESG0</accession>
    <name>A0A812ESG0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_81541</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005637">
        <property type="protein sequence ID" value="CAE1332509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ESG0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1332509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="221" mass="26389" checksum="296FDAE2EC371B29" modified="2021-09-29" version="1">MHQNTQKRPNSVVILFIFLSFIHSFIHSFFLSFFLLFFLSIFIHLLCLSILFFSIYLSIYLSIYLSIYLSSPVFPYLSIYLSIYLSIYLVCIFSFIHYVSIFSFFLQSIFPFFNSFLPVYFHSSISYSFFLSFFLSFFLLVNFHSFIMHFSFFFLSLPLHLSIYLSIYLSIYLSIYLSHSAHIYVSIYPILFISIYLSIYLSIYLSILQYKADEAFNLSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ET76</accession>
    <name>A0A812ET76_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_76609</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005494">
        <property type="protein sequence ID" value="CAE1327070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ET76"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="308"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="374"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="404"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="436"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="462"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="493"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="516"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="546"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="570"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="622"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1327070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="654" mass="73208" checksum="9DC7C28C3CAA0D9B" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ETM3</accession>
    <name>A0A812ETM3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_79010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005555">
        <property type="protein sequence ID" value="CAE1329589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ETM3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1329589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="258" mass="30038" checksum="1866645F899E4094" modified="2021-09-29" version="1">MSYSVHIYLSIYLSIYLSIYLSLSLSYIQHLSIYLSIYLSIYLSIYLSIYLFVCLSVFISMCSHLLIYLSIYLSIYLHRQINMASYNFIFLLILSLSILSISILLSCYLSSFQNYHYSCQTHSITLNMSSFLSFLISSHPLHFFPISLSNSKDYLLTLRLYTYLLTCQSISIGSTINIKRKTHLSIYHLSIYLSIYLSIYLHFLFISIYLSIYLSPNVHICLFTYVSFYVSTVALMLSMLYTNISTSGNRRDTLLVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EY51</accession>
    <name>A0A812EY51_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_80827</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005610">
        <property type="protein sequence ID" value="CAE1331635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EY51"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="334"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="357"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="384"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="417"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="441"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1331635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="474" mass="55427" checksum="3B9EF3B6310C424B" modified="2021-09-29" version="1">MYSDCLNHLCSFFASFFLSFFLSFFPSFDFVSSFLPFSFFLSFFLSFFLIVQARHSIRQCFHYRSSLHLEACPVCIPCLQSDGQRASSLVGLVFFFPRDDIRIERLNRMNRTSPTTSTFHETLLPSIPVVHCIWKLVQSVSRVFSQMVNVHLLCPRDAASIHSRRSLHLQACPVCIPCLQSDGQRASSLVGLVFFFHGMISRIERLQQPRHSTRRCFHPFPSFIAFGSLSSLYPVSSVRWSTCIFFGRPCVVFPRDDIQNRTSPTTSTFHETLLPSIPVAHCTWKLVQSVSRVFTSFFLSIVKTKLFYLNPSVLYKLSLFSFFLSFFLSFFHSFFLFFLSFILSFFLSLFLISNVKFLTHLFLPTFPVLTHFFFHSFIDSFNLFLFLCLFLCFFFFLISTAKFLLYLFCPFSHLNSFFLSFFLSFFLSFFLSFFLPSFLSSFLSFFLSFFLSFFLSFFPSHISLQLIQPFCIFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EY99</accession>
    <name>A0A812EY99_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_79423</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005566">
        <property type="protein sequence ID" value="CAE1329999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EY99"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="459"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1329999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="496" mass="57787" checksum="51472B79503EAFB7" modified="2021-09-29" version="1">MAVLVPDSDFFILSLILPLPFYLSIYLSIYLSIYLSISFLFLFCCLFSFYPLPWTISPSLPLYLSIYLSIYLSIYLSHSDHIYLFFFFPFYSFFLSFLSFTLVHFSYLSIYLSIYLSIYLSIYLILITSISFFFPFFFFFLLPWIISIYLSIYLSIYLSIYLSISFFFLFCFLFSFYPLPWTIYPPPLSLSLSIYLSIYLSIYLFFLSFLLSFFFLSFTLDHFSPTSLSLSIYLSIYLSIYLSIYLSIYLSVSLSNTICPSLSLSIYLSIYLSIYLIPSAPSLSLSIYLSIYLSIYLSIYLSIYLCLFTSIYLKLSLFSLSLSLSLSPSLWLYVSNCYLSIYLSIYLSIYLSIYLSIYLCAPLSFSHYLSIYLSIYLSIYLSICPSLFLTLSIYLSIYLSIYLSIYLIPSAPSLSLSIYLSIYLSIYLSIYLSIYLIPSAPSLSLSIYLSIYLSMPVHIYLKLSLFSLSLSLVVRFQLVRFPNKRDWCNTVFLGPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812F085</accession>
    <name>A0A812F085_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_80359</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005598">
        <property type="protein sequence ID" value="CAE1331145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812F085"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="291"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="321"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="388"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1331145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="429" mass="48060" checksum="0E4795CA247BFCC6" modified="2021-09-29" version="1">MTYSITYLYASLLTEIFASFSFDWFTLEFHIYIQAISLPVALHLALIFLNLFLIYKHLYIVYSYLSIYLSIYLSIYLSIYLSVFVRYLSIYLSIYLSIYMFSFDLYLPKLHLSLSLSLSLSLSLSPALSLSLSLFLSLSLSLSLSLFLFLSLSLYLSLSLSLSLSLCLSLSVSIPVSISLSISVSVSICFYPFLCLWLCLYLSFCPCLYPYLCLYLFTIPVSLPVSIPLSISVSISLSISLTLIHMQGHKCVLSYCVRPHYNYPVTTRLVWGKGRGKEDFLPVHSYYTPSYFLPLSPFSLFSVISICFSLFLVFAPSSLSLSLSLSFSVSLSSCLSFCLFFSLFRLADLQPLSLSLSLSLSRSLFFNQSVYLRRSFSVSLSASLSRSIAIFISFSVSLPICLSLFFSASLSLSLSFSVSLSICLSPSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AKS5</accession>
    <name>A0A812AKS5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_2210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000062">
        <property type="protein sequence ID" value="CAE1147696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AKS5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1147696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="275" mass="31744" checksum="951ACC9DF8B2D0EF" modified="2021-09-29" version="1">MCEDTRLSHSVRIYLSIYLSIYLSIYLSHSSVPFYLCTYLSIYQSVGMSANGLLISIYLSIYHSPFDIYLSITVCAYLSIYLSIYLSIYAIFLLISISIYLSIYLSHSVSIYILCGIYYSKANLSKSVRIYPSLFISIYLSIYLSIYLSLFISIYLSIYLSNLSIYLSIYLSIYLSMSVHFCPSMDLSMRINVCVFIYVCSYLSIDRSLIVCSYLLSIYLSILSIYLSIYLSQSVPIYYLSQSVRIYLSIYCLYLSMSVHVCVVIYVCLFISIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AKY2</accession>
    <name>A0A812AKY2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_407</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000006">
        <property type="protein sequence ID" value="CAE1139420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AKY2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039715">
        <property type="entry name" value="ZCCHC10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13491">
        <property type="entry name" value="ZCCHC10 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13491:SF0">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="341"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="385"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="435"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="482"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="516"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="569"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="639"/>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="665"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="706"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="746"/>
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        </location>
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        <location>
            <begin position="786"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="840"/>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="864"/>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="888"/>
            <end position="908"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="920"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1004"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1030"/>
            <end position="1058"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1139420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1059" mass="120451" checksum="AB39E9623307D774" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ALS3</accession>
    <name>A0A812ALS3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_694</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000018">
        <property type="protein sequence ID" value="CAE1140825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ALS3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1140825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="356" mass="42000" checksum="400B6DBDA81049AB" modified="2021-09-29" version="1">MHLSIYLSIYLSIYLSIYLSIYLNLFISIYLVLFISIYLSIYLSIYLSIYLSCSKINIFFLSKLLASIYLSIYLSIYLNLFISIYLSIYLSIYLVLLRSIYLSIYLSIYLKINIFFLSKLLASIYLSIYLSIYLTQFVHIYLSIYLSIYLSCSVEIYLSIYLSIYLSIYLSCSKINIFFLSKLLASIYLSIYLSIYLSIYLNLFISIYLVLFISIYLSIYLSCSVNIYLFIYLSIYHLENKYILPIEITCIYLSIYLSIYLSIYLSVTLFISILFCFYLSIYLSIYLSKTVWKWNMSIKKEKGTYSKIVTLPSYFYHFFFVFASCLFPSSCFWNKFTGANPVDKIETLYLLCGGMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AMU3</accession>
    <name>A0A812AMU3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GM2A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_1237</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000033">
        <property type="protein sequence ID" value="CAE1143034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AMU3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.220.10">
        <property type="entry name" value="Ganglioside GM2 activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036846">
        <property type="entry name" value="GM2-AP_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63707">
        <property type="entry name" value="Ganglioside M2 (gm2) activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1143034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="246" mass="28173" checksum="8A72EBF79FE0337A" modified="2021-09-29" version="1">MFKHVYVCNINNAISIYLSIYLSIYLSQFAFQIVVSPALKMLLVLVVSLTLLAGKGEALKWCQCGGDDNVLIQNVDITPEQLGMSRNAELSVEADILKPLNGSDISISAYQKSIFGYRKAPCIFGFGSCTYKNTCKSEKQINDTIWESDMNTVFTQVMEAFNAAVVNPGCPVPAQKIKLVKIPLTLPNKIYYWILFRKQYFSLYDFYFSLMWHRVFMRLNMFISIYLSIYLSIYLCIIRNRTKEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AN56</accession>
    <name>A0A812AN56_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_3476</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000105">
        <property type="protein sequence ID" value="CAE1152611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AN56"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1152611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="238" mass="27764" checksum="4950025978AFBCC2" modified="2021-09-29" version="1">MSHSFHIQNLFSYLTIYFSKFTSIYLSIYLSIYLSISKYLSRYLSTRFSLLISIYLSIYLSIYLSIYLTNSFMVISLYLSIFQPLMYVLIMIIFLPIYLSIYLSIYLSISIYLSQFTHIHSSIYLSIYLSIPACSLSIYLSIHLSISSSLFTIYSSIYLSIYLSIYLSLPACSLFIYLSIYLTFIYLSLTRSLFLRHPGSQSSLLVWARNEVNGRIDNRRFKIHFTLSDASSTRSRGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ASD2</accession>
    <name>A0A812ASD2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_4208</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000131">
        <property type="protein sequence ID" value="CAE1154412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ASD2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1154412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="346" mass="39972" checksum="6D10868F625AA5D2" modified="2021-09-29" version="1">MSFFSYISIYFSLFLSFCLSIYLFIYLNLLLSIYLSIYLSIYLSISDSLLFCAWLLFLPNSLTFFYSSFVFFRPSHSHPDYYFFFTFVSLTVPFSVPRFGWPFNFKPATSINNVSGFSQFSSTFTYPLTASAATFVARAAVCYLIVHHRSSSSYLSIYLSIYLSIYLSIYLSGKLYRPIAIYLSIPLSIYLLPIYLSHFVPVYLCLFLSIYLSIYLSQCVNIYLSIYLLRPLSFFLSFFLSFYLSIYLSIYLSPSVPISISLCSYLSIYLSIYLSIYLSIYLSLPLSLSLYLPFGEGPAWEKKREASYLNPPHGQAKGRTYDSHKTGTEFINVSLSRTWERSTLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ASL8</accession>
    <name>A0A812ASL8_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7041 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_6021</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000199">
        <property type="protein sequence ID" value="CAE1159626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ASL8"/>
    <dbReference type="OrthoDB" id="6159822at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055469">
        <property type="entry name" value="DUF7041"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327">
        <property type="entry name" value="ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327:SF3">
        <property type="entry name" value="RNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23055">
        <property type="entry name" value="DUF7041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7041" evidence="2">
        <location>
            <begin position="19"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="169"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1159626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="259" mass="29107" checksum="8191A4C49D1DD7EE" modified="2021-09-29" version="1">MAAAVTPFPPSHEGNIKNWFLQMEAIFTVRRITDQKTKFGHVVAVLPPAIVDEVADFLEAVPEVEPYARLKEAILRRMGRTEESLIRELFSNLTCDGRTPSQLLRYMKSRLGKNTMADSILKSLWLDRLPTTITQILAPMSENTPIDQLADAADRIFSQLDHRTTPVHSAEATGDHRSLEKTVEDLQRQVRDLTLAIESHGRSRLPPPQKSTSLVQSEQGCHFYYVTTTDDLGLQHTTAPSRVPILRSRKTKPPASESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AUA5</accession>
    <name>A0A812AUA5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_5384</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000180">
        <property type="protein sequence ID" value="CAE1157780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AUA5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1157780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="170" mass="19612" checksum="66B3E0338165E3F1" modified="2021-09-29" version="1">MVTKPSLPINALSSHAKFYTMYANFLSLSLSLSPSLSLSFFLSLVLSFSLSLSLRFLLFLSLCLFFFTLYLFLSLFLFRSFSFSLCLSFFSLFLYLSRFLSVSRSLSLLSFSLSLSLSFSVSVSFSFFLSFFLSFFLSLSPSLYFFLSFSFSFLYLFMFLTLYVSLSFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AUK8</accession>
    <name>A0A812AUK8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_5499</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000181">
        <property type="protein sequence ID" value="CAE1158004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AUK8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="202"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="300"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="396"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="424"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="524"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="562"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="592"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="622"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="760"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="784"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="479"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="479"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1158004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="827" mass="95028" checksum="2945A9C2B481F240" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AVX6</accession>
    <name>A0A812AVX6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_6222</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000204">
        <property type="protein sequence ID" value="CAE1160047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AVX6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1160047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="246" mass="28810" checksum="9EB0F57709940A71" modified="2021-09-29" version="1">MATRQVYRKIWTVISCDYLSVDSIYIYLSIYLSIYLSIYLSISVHAYLSISFIIYLRLFISISVSSLSIYLWIYLSMYIHISIYISINLSPYLSIPIHLSIPLHLSIYLSIYLSIYLSIYLSIYLSSYVSINLSIYLSQFIIYLRLFVSISVSSYISIYLCIFISLSIYLFIYPPISLSLFIYLSISVYNAKQNQSPHQNLSIYLSIYLSIYMEVSSSHLFTSIYLSIYLSIYLSIYLSFVAYLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AX67</accession>
    <name>A0A812AX67_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">LRRK2</fullName>
            <ecNumber evidence="7">2.7.11.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SPHA_5917</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="7"/>
    <dbReference type="EMBL" id="CAHIKZ030000195">
        <property type="protein sequence ID" value="CAE1159366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AX67"/>
    <dbReference type="OrthoDB" id="1866797at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056602">
        <property type="entry name" value="Beta-prop_LRRK2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF288">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23748">
        <property type="entry name" value="Beta-prop_LRRK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="25"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAE1159366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="663" mass="75464" checksum="B1F1F3A5DA52B476" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B348</accession>
    <name>A0A812B348_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_10484</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000337">
        <property type="protein sequence ID" value="CAE1169185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B348"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1169185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="296" mass="35856" checksum="0E296F8C3501A3B2" modified="2021-09-29" version="1">MNRLWVIFEIKWNRDSELPTLNHSNLSIYLSIYRSIYLSIYLCNTLIHLSIYLSIYLSIYRSIDQSIYLSIYLCNTFIYLSIYLSIYLSIYPRPYLPAFAFLTFFLSFFLSFFLSFFLSLVFIFEIFLLQSLYFELRSFFLSFFLSFFLSLLIIFEIFLLQSLYFELLSFFLSRSILSFFSFSFYCIRVLVFIFAFFLLQSLYFVLHSFIFSFFLSFFFLSFFLFIAFYFEIVSFFLSFFLSFSFFFLSLAHLFSIISLAVFFEIFLLQSLCFQLLSFFLSFFGTFIFDYFFGSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B3B0</accession>
    <name>A0A812B3B0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_8454</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000273">
        <property type="protein sequence ID" value="CAE1165424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B3B0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1165424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="239" mass="27308" checksum="9E6FD98EE65ACFB5" modified="2021-09-29" version="1">MLEDQTQSSDTTLTRSWKQQTSQTLPESSAQVHSHNVSIPLDYFTWRSAVPSQTDSKHKWLERDAVHVQEKTGMFKFKTTLDEDITTFQGVLNIKEYSKYISEQRQLIAPSYQVNSWPHPVPHMPTNDKVTDTLLSGSRQQLTSESKSQGSSDITSQMYTQNISIPPDYFTWRSAISSQNEAERDWTEADKFHGQEKTDLSSKFSSPFGQLNKSNISHPEMNHQQTPNARPLPPVPHLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B3F6</accession>
    <name>A0A812B3F6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_8524</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000277">
        <property type="protein sequence ID" value="CAE1165604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B3F6"/>
    <dbReference type="OrthoDB" id="6163184at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="5"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="534"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="623"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="542"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="575"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="650"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="690"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1165604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="832" mass="96506" checksum="92FE2063AD3E8938" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B3K4</accession>
    <name>A0A812B3K4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_10474</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000336">
        <property type="protein sequence ID" value="CAE1169121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B3K4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1169121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="155" mass="17573" checksum="04C4FBFA7174ECCB" modified="2021-09-29" version="1">MNLLILLPQFLSTPFLSRCLFSLSPPLSLCKVFLLFHSVSFFSLSHPMFILFVTLNFFFFPSISFPSLFLKIPSLSVSFTMSFLSLSRSLSLSLSLSFFFLSLFLNVFLSLYFSMSILYLNLFSVSLSISLLSFSLIVFHLPVSHGIYLLSVSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B3T5</accession>
    <name>A0A812B3T5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_8762</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000285">
        <property type="protein sequence ID" value="CAE1166169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B3T5"/>
    <dbReference type="OrthoDB" id="6819399at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134:SF22">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134">
        <property type="entry name" value="OS08G0543275 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="337"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1166169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="417" mass="48628" checksum="CB9751D6E00F9455" modified="2021-09-29" version="1">MNIHISICLYLSIYLSVFHYPSISDFSLPFISFSVCFLSISELSISIYLFIYIYQSIYLGLLIIYISIYLFFSLSIYPSSYLSMFLISVYFLSIYLSIYLSIYLSIYLSISVCSYLSISVCSYLSIYLSIYLSIYLSLLISIYLSIYLSQFVHIYLSIYLSIHQSIAICSYLSIYLSQFVNIYLSIYLSIYLSIHLSIAIVHIYLSIYLSQFVHIYLSIHLSIAICSYLSIYLLQFVHIYLSIYLSIYLSIYLSQFVNIYLFIYLSQFVHIYLSIHLSIAICSYLSIYLSLLISIYLSIYLSIYPSIYRNLFISIYLSIYLSQFVHIYLSISLSQFVHIYLSIYLSIAVCSYLSIYLSIYLSISVCLYLSQFVYIYLSIYLCQFVHICLSLFLHIYLSFSIFSLSLSLSLSLSLSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B4W8</accession>
    <name>A0A812B4W8_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase Pif1-like 2B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_10710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000349">
        <property type="protein sequence ID" value="CAE1169726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B4W8"/>
    <dbReference type="OrthoDB" id="6265497at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049163">
        <property type="entry name" value="Pif1-like_2B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492:SF57">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21530">
        <property type="entry name" value="Pif1_2B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="DNA helicase Pif1-like 2B" evidence="2">
        <location>
            <begin position="182"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1169726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="337" mass="37540" checksum="72019A424569D803" modified="2021-09-29" version="1">MISVNLPAKHALSGLTTYQSRHLILATSDFTRLFAFTSIYLSIYLSIYLSIYLSIYLMLPLHLTTNMRAHLTGDVGPAESSNSLLALGEGIIPANTNEFVNIQGLSTVVTTPATLRKSVFPDLQTNYNNIEWLARRAILAPKNTTVTTLNRQLLETVPGVLHVYKSTDRTPDPAEMANFPVEFLNSLHPAGLPPHILELKVEIPVILLRNLRPSKLCNGIRMAIQAVHPNIIEAKIITGCGKGEQVLIPRMHFYPSDADVPFTFRRSQFPVAPCFAMTINKAQRKTLSVTGVHLEEQCFSHGQLYVAFSRVGRREDVFLYSPLQKAKNVVYAEVLSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BAY8</accession>
    <name>A0A812BAY8_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">peptidylamidoglycolate lyase</fullName>
            <ecNumber evidence="1">4.3.2.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SPHA_13513</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Farmed</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds one Zn(2+) ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.5" evidence="1"/>
    <dbReference type="EMBL" id="CAHIKZ030000456">
        <property type="protein sequence ID" value="CAE1175236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BAY8"/>
    <dbReference type="OrthoDB" id="10018185at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004598">
        <property type="term" value="F:peptidylamidoglycolate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14958">
        <property type="entry name" value="NHL_PAL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000720">
        <property type="entry name" value="PHM/PAL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10680:SF36">
        <property type="entry name" value="PEPTIDYL-ALPHA-HYDROXYGLYCINE ALPHA-AMIDATING LYASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10680">
        <property type="entry name" value="PEPTIDYL-GLYCINE ALPHA-AMIDATING MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01436">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00790">
        <property type="entry name" value="PAMONOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51125">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 12" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032580976" description="peptidylamidoglycolate lyase" evidence="12">
        <location>
            <begin position="21"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="11">
        <location>
            <begin position="123"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="11">
        <location>
            <begin position="179"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>a protein</name>
            <dbReference type="ChEBI" id="CHEBI:16541"/>
        </ligand>
        <ligandPart>
            <name>C-terminal Xaa-(2S)-2-hydroxyglycine residue</name>
            <dbReference type="ChEBI" id="CHEBI:142768"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>a protein</name>
            <dbReference type="ChEBI" id="CHEBI:16541"/>
        </ligand>
        <ligandPart>
            <name>C-terminal Xaa-(2S)-2-hydroxyglycine residue</name>
            <dbReference type="ChEBI" id="CHEBI:142768"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>a protein</name>
            <dbReference type="ChEBI" id="CHEBI:16541"/>
        </ligand>
        <ligandPart>
            <name>C-terminal Xaa-(2S)-2-hydroxyglycine residue</name>
            <dbReference type="ChEBI" id="CHEBI:142768"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR600720-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600720-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600720-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAE1175236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="361" mass="40704" checksum="BEC12441C0C090EA" modified="2021-09-29" version="1">MTLNWLYLFFLFAANGICSPRHRQKTWESNLPLYNEPEEINLNDFAHEVRWPNNLIGVASWPEWKDSTVRQVTGLGTNTRGDVVVFHRGTREWGVRSFDRSNKFRGHGPIKQNTIVTLTNSTGTKISAFGANLFFLPHGLTVDHEDNIWTTDVGLHQVMKFPPGATKPSMILGTRLLPGNDKSHFCKPTDVEVASNGDFFVADGYCNSRVVKFAKNGTVLSYIGETSQLKVVHSIALVEQLDRLYVADRENRRILCFKAGLKNEHEAGEFVSSFAKRRLGRIFALKYDPNMNVLYVVSQLMGRGLGSTIDLLNGEVIANWPTAHYPRDNSLPHDLAVAPNGQAVYVADIRQERNPLFKLQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BCK0</accession>
    <name>A0A812BCK0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_14850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000512">
        <property type="protein sequence ID" value="CAE1177845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BCK0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134">
        <property type="entry name" value="OS08G0543275 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134:SF5">
        <property type="entry name" value="OS08G0543275 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="331"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="361"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="405"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="433"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="460"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="489"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1177845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="509" mass="58502" checksum="69229BB8CE4F2991" modified="2021-09-29" version="1">MTETASVSCLSIRARRDPQETYLHSSTDANIGTHRHSKGTHKAHIWATAKGYSVTYISKPVAYLSIYLSIYLSIYLSIYLSLFISYLSIYLSIYLSIYLSLFIIYLSIYLSIYLSIYLSQSVHIYLSIYLSHSVHIYLSIYLSIYLSLFIIYLSIYLSIYLSIYLSLFISIYLSIYLSIYLSKSVTYLFVAYWTIVRIIYLSIYLSIYLSIYLSNSLPPFTSLQTRQLFISASLSTDIHIFSIFLTPLTLLLLLLLLLLLPLSLSFSSFLPLSLLLSLPLSSYRHVDGGNISFVFASINLSIYLSIYLSIYLSIYLYLLIISRSSTSFSSFLLLLFVFFFFFSSFSSSSCCTSFSSSFSSFLLLLFVFFFFSSCFSSCFSSSCFSSCFSSFSSSSFSSSSSSSSFYPYLSIYLSIYLSIYLSIYLSIYPSLSISIYLSIYLFIYLSQSIHIYLSIPVYPYLSIYLSIYLSIYLSIYLFIYLSIPVYPYLSIYLSIYLSIYLSIYLSIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BFA0</accession>
    <name>A0A812BFA0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_16403</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000575">
        <property type="protein sequence ID" value="CAE1227449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BFA0"/>
    <dbReference type="OrthoDB" id="6161790at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134:SF22">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134">
        <property type="entry name" value="OS08G0543275 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="336"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="364"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="402"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1227449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="424" mass="49286" checksum="BC31E6D58FB2C173" modified="2021-09-29" version="1">MPRCHKLSSLSNPICYGLPSADHSHVHRALRSFSANRLSCSLRLSPLPLILTVDFLTSLFVDIYLSIYLSIYLSIYLSIYLSQSVDIYLCIYLSLFISIYLSIYLSIYLSILVCSNLSIYLNLNISIWLTAKSLGNTGSRTITEVKQPRACRKKQITRSINIYLSIYLSIYLWMHLALLGKTAVRGGGKSIYLSIYLSIYLPIYLSIYVCPYLSIYINYLTISVCLYLYQSVNIYLFIYLSIYLSRSLYIYLSLSIIYLSIYLSIYLYIYLYIYLCQSVHIYVSLFIIYLSIYLCQSVSISIYLAIYPSLFISIYLNLFISIYLSIYLFQSVSISIYLAIYPSLFISIYLNLFISIYLSIYLSIYLSVCLSVSVYLSIYLSIYLSIWCYWRNKYSYSLSLSLSLSIYLSIYLSIYLSHTYIHIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BHS2</accession>
    <name>A0A812BHS2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_17796</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000636">
        <property type="protein sequence ID" value="CAE1230593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
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            <end position="63"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="146"/>
            <end position="167"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1230593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="171" mass="19897" checksum="A541B589E32AE198" modified="2021-09-29" version="1">MNLSLFLIFSMPPICRSFTLSLFLFSSIPSISLCFALILPFLCSPFHLLLSIYLFLFILSFFFRSNYISLQLSHILILINIYRPLFHTLALSLFNQPFFHTLTLSLLLHAIYLPLFHTIHLPLFPNLAISLFLHTIYLSLFPNLAISLFLHTIYLSLFHNLALSLFLHTIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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    <name>A0A812BHT5_ACAPH</name>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_17013</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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            <taxon>Cephalopoda</taxon>
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            <taxon>Sepiidae</taxon>
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                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000602">
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
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        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAE1228833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="401" mass="47340" checksum="72EFF44217813C8D" modified="2021-09-29" version="1">MYLSILFYSYLFFYLILYSYLSIYLSSAILIYLSYSFPIYQSIYLSIYFPSVLSIYLSIYLSIYLSIYLLIYLSIYLSIYLSIYLSIYLCTYLSIYLSIHLSTYVPIYLSIYLSIYLLIYLSIYLSIYLSIYLSTYVSIYLSIYLSIPIYLSIYLSIYLSIYLSIYPSIYLCTYLSIYLSIYLLMYLSISFYSCIYLSVCLSIYLSHSVLSIYLSIYLSISLLNLLFLFMSISVTFYLYLCLCLSFPPFISIYLSIYLSIYLSIYLHVVCLSMYCSLFIHLSISICLYLSIYSYFRLLLLLLYLYVYLNHSLSLSLSLFASVFLSLCPFISIYLSIYLSFFLSFFLSIYLSIYLSIYLSFSFYLSIYLSIYLSILFCSYLFPHLISHSSHIYLSISVAFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BM15</accession>
    <name>A0A812BM15_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_20197</name>
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    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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            <taxon>Cephalopoda</taxon>
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            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
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            <taxon>Sepiidae</taxon>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <dbReference type="EMBL" id="CAHIKZ030000740">
        <property type="protein sequence ID" value="CAE1236356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A812BM15"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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            <end position="255"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAE1236356.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="258" mass="29897" checksum="E32204E9C452E439" modified="2021-09-29" version="1">MFSEISYIYLSIYLSIYLSIYLCSYLLFISIYLSIYPSFFISICLNLLIAISIYLSIYLSIYLSIYLSIYFGLSRGLSGAASFAPIRSHPEDNISSPFREKPGKLLAFFFSHLSIYLSIYLSIYLSISFCSSMFLSFFLSIYLSIYLSHSVNLSIYLILLIYLSISFCSSMFLSIYLSHSVNLSIYLSIYLSIYLSISFCSSMFLSFFLSIYLSIYLILFIYVSFFLSFYLSIYLSHSVHLCFFLSFFLSIYLSISFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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    <protein>
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    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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            <begin position="2844"/>
            <end position="2868"/>
        </location>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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        <source>
            <dbReference type="EMBL" id="CAE1239424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="2875" mass="338631" checksum="4A4CE415764458E0" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BPD5</accession>
    <name>A0A812BPD5_ACAPH</name>
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        <recommendedName>
            <fullName evidence="6">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="7" type="ORF">SPHA_21041</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000775">
        <property type="protein sequence ID" value="CAE1238050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BPD5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    </dbReference>
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        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
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        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAE1238050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BR47</accession>
    <name>A0A812BR47_ACAPH</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">SPHA_21303</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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        </lineage>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000780">
        <property type="protein sequence ID" value="CAE1238384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BR47"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </feature>
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            <end position="138"/>
        </location>
    </feature>
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            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1238384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="200" mass="24734" checksum="E960FB6B405C02A0" modified="2021-09-29" version="1">MSHSTDFFICQFSHELHSFLTFISLTLFVSISSLFFSLFFSLSLSYVNTRPIKKKKNFKNIHFFFFLSIPFFLFSIFLSFFSLSFFLSFFLVIYLFYFLSFFLFPFFLFPFFLFFFLSFFLFSFFLSFYLFLLLFFFLSFFLSFFLFSFFLFFFLSFFIFSVFLPFLFLSFFLYFFLLLFLSFFSFFFLLSSFLSPFFFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BS21</accession>
    <name>A0A812BS21_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_22964</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000847">
        <property type="protein sequence ID" value="CAE1241677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BS21"/>
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    </feature>
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            <begin position="107"/>
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    </feature>
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        <location>
            <begin position="141"/>
            <end position="159"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1241677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="265" mass="31765" checksum="D9FBE2946D9ED45C" modified="2021-09-29" version="1">MFLSLSLSLSLSLKLLLTPLLLSFTYLSFFLILHPDTNLFIQFLFALIFNFRNSTPSYRCYLLLSLVSFNSYTFSFTSLFLFIFFIIPFPFYHKFSHKSFFLSHFFYSISVFLYLSFFLVCYSFSIFLYRSFFLSLSQSSFFSWSIFFPIFSFILSFFNMSFNISSTSPFFLLRVCSFFLLRVFSFFLLQFFFLFQLFIPNYYFFHAKKNLSLCYSPFYLHVPTLSLYQYYIITPPLPTTTTASFYYTSNLHPFFSSFVSSFHFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BT02</accession>
    <name>A0A812BT02_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_23470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000868">
        <property type="protein sequence ID" value="CAE1242818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BT02"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033015640" evidence="1">
        <location>
            <begin position="25"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1242818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="155" mass="18064" checksum="88BC4B93C886F00A" modified="2021-09-29" version="1">MVLSIYLSIYLSIYLSIYLSPSQAQTCGPYYGKRNDNFRCLLLLDANNKFPLLFFLSFSICSYFRTSLPYHQLRNHQPHIFIAKLSDPPSKEDKNRDQETLYYRGRHLTGQKSPIFALQQHQEPLTLSSKLAERPYCFHSIPGVLESMWNGCLFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BTW1</accession>
    <name>A0A812BTW1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MOB-like protein phocein,MOB kinase activator-like 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_26818</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001025">
        <property type="protein sequence ID" value="CAE1249831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BTW1"/>
    <dbReference type="OrthoDB" id="184876at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.30">
        <property type="entry name" value="MOB kinase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005301">
        <property type="entry name" value="MOB_kinase_act_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036703">
        <property type="entry name" value="MOB_kinase_act_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22599">
        <property type="entry name" value="MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03637">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01388">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101152">
        <property type="entry name" value="Mob1/phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605301-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1249831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="221" mass="25444" checksum="58C12293C3B7C850" modified="2021-09-29" version="1">MADAPAVVRRNRPGTNIEKWCRWPDESFDEMESTLAVQQFIQQAIRKDVTNIEAILTPPEGQDEGVWKYEHLRQFCMELNGLAVKLQNECNPNSCTQMTATEQWIFLCAAHKTPKECPAIDYTRHTLDGAACLLNSTKYFPSRVSIKESSVAKLGSVCRRVYRIFSHAYFHHRMLFDEFENETNLCRRFTTFVTKYNLMPKDNLIVPILEDQAALNGESEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BTX1</accession>
    <name>A0A812BTX1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ChlI</fullName>
            <ecNumber evidence="2">6.6.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_22678</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.6.1.1" evidence="2"/>
    <dbReference type="EMBL" id="CAHIKZ030000840">
        <property type="protein sequence ID" value="CAE1241115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BTX1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016851">
        <property type="term" value="F:magnesium chelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1241115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="245" mass="30530" checksum="DD9886CE123DC7CC" modified="2021-09-29" version="1">MIFITLHFGLVPFFHFVFLLLSFVFLFCLSSFFLSFFLSFLSFSFFLSFFSFWLSFFFLSYSWSAFFLSSFTFFYRSFFLYFFNLSFFLFFFLFHSFFSFLFSFLSVFLSVFLSVFLSFFLILRSFFLLFLSFFLSFFLSFFLSFFHFHFHFLSFFFFVFLLSFFDFSFFLFFFLLIFNFFFFLHFFSFSLSFFRPCFYLSFFLSLFHFVFLSLSFSFFFLSSFLFLSFYLFHSFFSFLFSLLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BUN4</accession>
    <name>A0A812BUN4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_23259</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000860">
        <property type="protein sequence ID" value="CAE1242323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BUN4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="415"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1242323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="444" mass="52674" checksum="B3D1CF65ABFA4850" modified="2021-09-29" version="1">MSLHIYLSIYLSIYLSIYLSPPPPPPPPSSSSSTVPIYLSIYLSMSLYIYLSIYALLYRSIYLCISVWPSIYVSSYLSIYLSIYLCLFISIYLSIYLSIYLCLFKSIYLPIYLCLFISIYRCLFMYIYLSLFIFYLSIYVSSYLSIYLSISICLFISIYLILFISIYLSIVKENMTQPCFRVKARIKLTTNARTSAIIPLGHLSIYLSIYLSIYLSMSIYLSIYHSSIIHIPVYPSQFVHISIYLICSYLSIYLIHIYLSVYSYPSLFSIHPSFIYLSIYLSIYLSIYIYLYLSIYLSIYLSSQFVHIYLHIYIYLSVHIIHISSIYLSSIYLSISVYSSIYHLYLSQLSYLYYLSIHFYLSIDCFIYFTMIEHIYLSVYLSIYRFICLSTYLSSVISVYLWSYLPVYLSFFEQIYLYLSIYFTSIFEYIYLSIYLSIYLSIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BUU8</accession>
    <name>A0A812BUU8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_24439</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000912">
        <property type="protein sequence ID" value="CAE1244747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BUU8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134:SF22">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134">
        <property type="entry name" value="OS08G0543275 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1244747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="163" mass="19433" checksum="C8B03E59D1719DD0" modified="2021-09-29" version="1">MYFVFHFDLSIYLSIYLSIYLSISFYLCMNIHLYTHIYIYVCILFFISIYLSIYLSIYLSIYLSIYLSIYLSISLCIYFSLSLSLSLSIYLSLFICMYVSIYLSQFISIYLSIYLSIYLSISICSYVCMYVSVYLSQFVHIYLSIYLSIYLSIYLSIYLSIYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BW11</accession>
    <name>A0A812BW11_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_24023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000891">
        <property type="protein sequence ID" value="CAE1243854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BW11"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1243854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="264" mass="31304" checksum="D1DD0EF7A78A6701" modified="2021-09-29" version="1">MVSSSPKSAWHMWKICQLASLFLSIYLSIYLSIYLSIYLSQSLHIYLSIYLSIYLSIYLSIYHSLFISIYLQSVHIYLSLTIYLSIYLSIYPNLFISIYLSIYLSIYLSIYLSITVFSLSIYLSIYLSIYLSIYLSQSFHYLSIYLSIYLSIYLSIYLSQSFHYLSIYLSLTYTEANGQHFNFFVPFVFPWSHGSFTPDKAGYLLVRKTGMWFLQHWANFQIFYTTLAWTYLKRIDRTCGMFQNSLYSYNKHNQVTDRLETSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BWS3</accession>
    <name>A0A812BWS3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_25488</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000966">
        <property type="protein sequence ID" value="CAE1247115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BWS3"/>
    <dbReference type="OrthoDB" id="421040at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1247115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="176" mass="19630" checksum="85691ACAED5574FB" modified="2021-09-29" version="1">MSLSSFLSRWFSLLESDRCLSCGSINKRKRISILSLSLSLSLSASQRNEPTQIDASEVLRATSLLILFRKVHLKIRKSVRIPTDDSLATAIDQALNLNSSLDWDHFFLFRNTCARHFFHHPSMLNVSNNIISSATGIQQDDPLGPLLFAMSSTRYLVTSPLLSTYGNLTSQGTVEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BY27</accession>
    <name>A0A812BY27_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Guanine nucleotide-binding protein-like 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SPHA_28945</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Farmed</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Possible regulatory or functional link with the histocompatibility cluster.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001146">
        <property type="protein sequence ID" value="CAE1254434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BY27"/>
    <dbReference type="OrthoDB" id="391988at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043358">
        <property type="entry name" value="GNL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45709:SF3">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45709">
        <property type="entry name" value="LARGE SUBUNIT GTPASE 1 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CP-type G" evidence="7">
        <location>
            <begin position="1"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="354"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="357"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="382"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAE1254434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="418" mass="47044" checksum="9F591AB4B7E85A3B" modified="2021-09-29" version="1">MSDIILLITDIRHPAVHFSPALYDHVTKDLGKPLILILNKIDLAPPALVVAWKHYLQEKFPMLQIVCFTSYPKDKSDIDMQRDDPGKVMHKKRKRGKSVAVGPLELWQACQTIVKDEVDLSGWKKKIEANVSAVESDLVSIVHNEIADTSYQQHVRYKDGIVTIGCVGYPNVGKSSLLNGLVGKKVVSVSRTPGHTKHFQTIFLTPTVKLCDCPGLVFPSKVLKQLQILCGIYPIAQVREPYSPLMYLAQRINLVKLLKLQHPAVDHNRPYQGGWSAFDICDAWAQKRGFMTARTARPDLYRAANHLLRIAVDGRLCLCFRPPAYSKTKDYWEKHVETEALWLIQHQHCRRNQAISDESESLSSSDEEIGGEDGISKCQKPTSKTSDSTTTTKEDDDQDSESENNLVSKNPFDLLDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C0B7</accession>
    <name>A0A812C0B7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transmembrane protein 94</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_25991</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000990">
        <property type="protein sequence ID" value="CAE1248095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5568754at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039720">
        <property type="entry name" value="TMEM94"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13219">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 94"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13219:SF6">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 94"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="628"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="655"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="683"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="716"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="750"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="780"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="820"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="877"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="910"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="948"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="974"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1008"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1655"/>
            <end position="1676"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1697"/>
            <end position="1726"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1767"/>
            <end position="1784"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1796"/>
            <end position="1817"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1837"/>
            <end position="1856"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="11"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1301"/>
            <end position="1357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1428"/>
            <end position="1483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1322"/>
            <end position="1332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1428"/>
            <end position="1440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1462"/>
            <end position="1475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1248095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1885" mass="213449" checksum="3685A8BC456904F3" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C0M9</accession>
    <name>A0A812C0M9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_30307</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
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            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001217">
        <property type="protein sequence ID" value="CAE1256651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C0M9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="340"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="409"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="442"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="476"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="512"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="538"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1256651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="564" mass="65690" checksum="01D4CFFB0337A33F" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C0X4</accession>
    <name>A0A812C0X4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_25229</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000954">
        <property type="protein sequence ID" value="CAE1246515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C0X4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
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        <location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        <location>
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            <end position="151"/>
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        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1246515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="279" mass="32311" checksum="EA30203EF2233B20" modified="2021-09-29" version="1">MLGNADMVSIFQKRLICLSLSLSQLPSLPFFPHCLIYSLFHIIISHSCRFQFFFVLYYSSSPSFFSVSSLRLLCFLSSFLSFSHLFHFLLNAFNVLFFFCSSLSSFSFLFLLILFFFFSSSSPSSAYLPLFFFYCSIFFSSFIIFLFFSLFPSSFSFHPSLLPLRYCSLFIIRLAFFSFSSLSPLSLFLSFFSPLFLLLFTFIILPPFFPFTFFSFPIYSSSFISVSFHFFLSSPFFSSLSFNPLSIKITQSPTFFNIFFLFFSLGCLSTSFVSTPSIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C5W0</accession>
    <name>A0A812C5W0_ACAPH</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_30107</name>
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    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
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        <lineage>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">Farmed</strain>
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    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C5W0"/>
    <dbReference type="Proteomes" id="UP000597762">
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            <end position="98"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="154"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="174"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1256342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="201" mass="23398" checksum="B35DC01873EEB3B3" modified="2021-09-29" version="1">MITQACITHGTVCLHLSIYLSIYLSIYLSIYLSISVCLHLLIYLSLFTSIYLSIYHSLLISIYLSIYLSIYLSIYLSRSVYIYLSISVYSHLSIYLSIYLSRSVYIYLSILVYSHLSIYLSIYLSIYLSRSVYIYLSISVYSHLSIYLSIYLSIYLSRSVYIYLSISVYSHLSIYLSIYLSISVCLHLLIYLSLFTSIYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C6G9</accession>
    <name>A0A812C6G9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_28559</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
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        <lineage>
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            <taxon>Coleoidea</taxon>
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                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
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    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001116">
        <property type="protein sequence ID" value="CAE1253696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C6G9"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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            <begin position="365"/>
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    </feature>
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        <location>
            <begin position="398"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="423"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1253696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="449" mass="53071" checksum="1F9768F2277F1387" modified="2021-09-29" version="1">MFFYFYLFCSTCLFILFSSFLFLFPFFFFVFFVNFLFFLSFYSSFTFSFPSHSILHSFFCLLFLFLPFLFFLLFSFFFFSPFSFSFIHFVVLSLFLSFSFFFFFLSFVLHSLFFFSFLCTFFTFLFSFFPFALSRYLFFFAFFFAFFFSSQCLSFYNLSRSLSLSPAPSLSPAPSLSPSLSSSPSLSLSILIQSLSLSLSLSLSLSLSLLSVYLSIYLSIYLSIYLSIYLSLSISIYLSQSEYIYLSIYLSHISIYLSIYLSLSISIYLSIYLILLIAINKYIFNLINFYLILYIAMNQFQLINLSIYLSIYLSISYIYLSIYLSIYLSISLINLSIYLSIYLSISDSTLSINLSQHVRICRSHLFLSIYLSIYLSHSDYSLISIYLSIYLSIYLSHFFIWLLCFHGLSLIYLSIYLSIYLSLFIYLSIYLSIYLSLYIYIYIYIYIYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C6M5</accession>
    <name>A0A812C6M5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_30518</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
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        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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            <taxon>Coleoidea</taxon>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001225">
        <property type="protein sequence ID" value="CAE1256993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C6M5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1256993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="170" mass="20094" checksum="51A083A5FD72DA0E" modified="2021-09-29" version="1">MVDEALYIKLHALKFSFYANIIYLSIYLSIYLSIYLSIYRYQSIHFTLFIYVLDCIHIYLSIYLSIYLYLSIYLSIVISLIIFLCPFIDLTAFISIYLSIYLSIYLSIYLSIYLYISQACGKPIFSFLFFEPGAHISIYCKFVTLHSYLSIYLSIYLSIYLSIYLSVNEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CBX7</accession>
    <name>A0A812CBX7_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein CASP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SPHA_30639</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CASP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001235">
        <property type="protein sequence ID" value="CAE1257201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CBX7"/>
    <dbReference type="OrthoDB" id="10257567at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012955">
        <property type="entry name" value="CASP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057476">
        <property type="entry name" value="Cux_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14043">
        <property type="entry name" value="CCAAT DISPLACEMENT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14043:SF2">
        <property type="entry name" value="HOMEOBOX PROTEIN CUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08172">
        <property type="entry name" value="CASP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25398">
        <property type="entry name" value="CUX1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="623"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="domain" description="Cux N-terminal" evidence="13">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="CASP C-terminal" evidence="12">
        <location>
            <begin position="418"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="105"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="290"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="402"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="506"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF25398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAE1257201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="670" mass="77599" checksum="739A55A95C4D34AA" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CCG8</accession>
    <name>A0A812CCG8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_31679</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001306">
        <property type="protein sequence ID" value="CAE1259397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CCG8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1259397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="156" mass="17479" checksum="905137D8D3A81E74" modified="2021-09-29" version="1">MSRTAVHLNVFTSTCLGKYSCPLERVHLNVSTSTCLCKYSCPLERVHFHLSRIAVKSNVSTSTCLAKYSCPLERVHFHVIAVHLNVSISTCLGKYSCPLERVHFHVSRQVYLSNRTSPLPRVSPGIAVHLNVSTSTCLGKHSCLHERVHFHVSRQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CE13</accession>
    <name>A0A812CE13_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="6">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SPHA_36020</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="6"/>
    <dbReference type="EMBL" id="CAHIKZ030001558">
        <property type="protein sequence ID" value="CAE1268159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CE13"/>
    <dbReference type="OrthoDB" id="8118055at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044322">
        <property type="term" value="C:endoplasmic reticulum quality control compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904380">
        <property type="term" value="P:endoplasmic reticulum mannose trimming"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044674">
        <property type="entry name" value="EDEM1/2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45679">
        <property type="entry name" value="ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45679:SF6">
        <property type="entry name" value="ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="275"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="368"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAE1268159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="437" mass="50012" checksum="1051EE3EB4DD4EE6" modified="2021-09-29" version="1">MFNTFCRRRMTESCSQKRRYVYYFSAVFILLFITPGYRCHVRKITEADLRMYRKRVVDMFNHAYEGYMKYAYPLDELRPLTCDGHDTWGKFSLTLIDSLDMLAVIGNYTEFRRVAKLILDKANFDIDINASVFETNIRVVAGLLSAHLFSKKAGMDTDPGWPCSGPLLDLAENMARRLLPAFDTPTGMPYGTINLRHGVPSGETTVTCTAGVGTFIVEFGTLSRLTGDPIFEKAAMRALSTLWKCRSDINLFGNHVDVRTGKWIALDMGIGGGVDSYLEYLVKGSIMFNSPELLSMFNECKESVEKYLKRDDWYMWGNMKKGSITLPVFTSLDSYWPGIQSLLGETEKAMKTIHNFHQVWKQFGFVPEFYNIPKADVHTNREGYPLRPELIESSMYLYQATKDPYLLQIGIDMLESIEQVTKTRCGYATVIILYQFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CF32</accession>
    <name>A0A812CF32_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_32325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001341">
        <property type="protein sequence ID" value="CAE1260666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CF32"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1260666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="251" mass="29778" checksum="624C78DDEB55D605" modified="2021-09-29" version="1">MIFLCKVIQYLSIYLILFNIYLSIYLRLFIIYLSIYLSICTYLFCSYLSISICSYLSIYLSIYLSQSFHIYLYRSAHIYLSQSVHIYLSIYLSLFSIYLSHSFQNLSTYLILCSIYLSISFFSESIYLSHSFRYLPTYLSHLLLSVYLSEFVHIYLFIYLKMFIFLSLFISISVYIYLCSLSIYLSIYLSIYLSIYLSIYLSLFIYLKMIIHPSQFISIYVCSLSIYLSIYLSIYLSLFTISLSESAHLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CHP6</accession>
    <name>A0A812CHP6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_34416</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001458">
        <property type="protein sequence ID" value="CAE1264850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CHP6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1264850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="279" mass="32460" checksum="8DBB547488AF276E" modified="2021-09-29" version="1">MLSFLSHAQMLESFSFSIYLSIYLSIYLSIYLSIYLSHIHTQNQSIYLSIYLSIYLSNLNSSSNSLFSSKVCFHTLLILFFHFSPLLIVFYFLPLHFLPPLKLTHIDTSHSFSFSFSFFTTHLFIPFHSSFYFLSFSFSFRFPAISFRLHAISSGPLFFILAPLIPCSASVFPQPATPLHLLRVLILHANKLILSQLHLSSFKYLITFSLDLSIYLSIYLSIYLSIYLCVRTYTPKQSSRRIFKYTQSCSLTRSMNTLKHIFCYLSIYLSIYLSIYLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CHR9</accession>
    <name>A0A812CHR9_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cytochrome b5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SPHA_34955</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Microsome membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
            <orientation evidence="11">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12 14">Belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001497">
        <property type="protein sequence ID" value="CAE1265948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CHR9"/>
    <dbReference type="OrthoDB" id="260519at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000002">
        <property type="entry name" value="Cytochrome b5 type B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050668">
        <property type="entry name" value="Cytochrome_b5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359:SF150">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 14" id="KW-0349">Heme</keyword>
    <keyword evidence="9 14" id="KW-0408">Iron</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0492">Microsome</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="15">
        <location>
            <begin position="14"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00039806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAE1265948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="169" mass="19074" checksum="707AACEB3830A53F" modified="2021-09-29" version="1">MTTKTEDGCGETPTKVYRLHEVQQHKDNSSTWMIIDNKVYDITKFLDEHPGGEEVLLDQAGGDGTEPFEDVGHSSDARIMMKNFYLGELHEDDRKERPKISFLPPNSDHKIKPSEICTKSNNFLSLSSPTQPIEVPFSRNSWTNWIVPIGIALAVALLYRYVTSPGYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CI91</accession>
    <name>A0A812CI91_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_35158</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001511">
        <property type="protein sequence ID" value="CAE1266449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CI91"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1266449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="296" mass="34557" checksum="7DDF436B15BAADE8" modified="2021-09-29" version="1">MTVSKQEKSCLCHSVHIYLSIYVSIYLSIYLSIYLSQSVDIDLSLFIYIYLSIYLSIYLSIYLSQSVDIDLSLLISIYLSIYLSIYLSIYLSIYFILLIFICLSSVFCSYLSLLISIYLSIYLSIYLSIYLSQPVDIYLSIYLSIYLSIYLSIYLSIYLSIFPLAIDRSMSVYQRQSSVHIYLSIYLSIYLSIYLSIYLSLLIFICLSLFISIYLFISIYLSIYLSIYLSIYLSIYLSQSVDIYLSIFSTLDIDRSMSVWSVHASIYLSIYLSIYLSIYLSIYLHLVSSTRKDLKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CIP0</accession>
    <name>A0A812CIP0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_39862</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001870">
        <property type="protein sequence ID" value="CAE1276132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CIP0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1276132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="273" mass="31447" checksum="8BB430CDEA28374B" modified="2021-09-29" version="1">MFMYITLSSDRKIQSTSGRFQIVISIYLSIYLSIYLSCSDLSIYLSILFRSIYLSIYHIMIIFISIIFSLSLSLSLSLSVTVYPYISEFVFLFSSPSLSIFLSFFLSIYRMVLSIHSVHVYPNSLSLSLSLSLSLSLSHDIYIYLANSRGRINISFCLSVCLSVFFLSVEKFHFLLLSTFLDLFFHSLSPFFSFSLSFHSTFYPFLNSLSLTVTLSSLSCSLLSFLNPYFSFPHSFLILFFLYLCPFFKLFFLSTSSPSLFPLKLSPFQLKEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CIP4</accession>
    <name>A0A812CIP4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_35380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001520">
        <property type="protein sequence ID" value="CAE1266901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CIP4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1266901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="323" mass="37111" checksum="B0D1E8137F2567F0" modified="2021-09-29" version="1">MLFFSSSSSSSSSSSSSSSSSSSPPPPSSSLCRVPSRLSIYLSIYLSIYLIPSIFIYLSIYLSISFCPSIIYLSIYLSIYHSVHIYLSIYLSIYLSIYLSISFCPYLSIYLAHSLHIYLSIYLSIYLSIYLSHLHLHLSSSFYPYLSIYLSIYLSIYLYLSHSVHIYLSIYLSIYPYLSSIYLSIYLSIYPILSISIYLSISSICLSIYLSIPFCHIYLSIYLSIYLSVQSSFCLSLSIYLSIYLFIYLSIYLSIPFCSYLFIYLSIYLSIYLSIYSVHSISSISISIHRFYSFFFVQNNQIRESLSEQSDELPPPPDSSNSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CIR7</accession>
    <name>A0A812CIR7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PTPRG</fullName>
            <ecNumber evidence="6">3.1.3.48</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SPHA_38354</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="6"/>
    <dbReference type="EMBL" id="CAHIKZ030001735">
        <property type="protein sequence ID" value="CAE1273611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10001713at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000028">
        <property type="entry name" value="Neuronal cell adhesion molecule"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000298">
        <property type="entry name" value="Cyt_c_oxidase-like_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050964">
        <property type="entry name" value="Striated_Muscle_Regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817:SF166">
        <property type="entry name" value="NEURONAL IGCAM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817">
        <property type="entry name" value="TITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="COX3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
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            <begin position="782"/>
            <end position="1110"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
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        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAE1273611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="2038" mass="252058" checksum="CB4AB64905B1C12A" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CIS8</accession>
    <name>A0A812CIS8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_35577</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001535">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CIS8"/>
    <dbReference type="Proteomes" id="UP000597762">
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    </dbReference>
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        <location>
            <begin position="20"/>
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        <location>
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            <begin position="246"/>
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        </location>
    </feature>
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        </location>
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            <begin position="334"/>
            <end position="344"/>
        </location>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1267388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="344" mass="41325" checksum="AA35C299366E2711" modified="2021-09-29" version="1">MPREDVALHKFISLYLKKRFTLVNLFCDELVLSKIYNYFCPLSIYLSDFFHYLSNLVHYLSIYLSIYLSIYLSIYLSIYLSISDDFIYFFLSFFFLSFDVNLDSSAFSFPFISESHFFIPFFRFLFRFPATSICLFHFFFFLFVFRQGSFPFSFLFFSLSFINCVHLLLPFLFLSLSFSGRVHSLLPPPFFFFYVLLLFYYLFLLSFSFLVVFHPRCFIVFFIYFFFSLHFLSLFLFILIFQVPLYFSLLFCYLFLYLSLFLLLSRRLIFSLFTFKINNHKICRSSPSSLLDFDILSDSLPFPFFIFFFLLYFSATADTRPPPPPHTSTYERPAKKKCKSHLSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CQ95</accession>
    <name>A0A812CQ95_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_38016</name>
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    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Coleoidea</taxon>
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            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001717">
        <property type="protein sequence ID" value="CAE1273185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CQ95"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <begin position="24"/>
            <end position="46"/>
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        <location>
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            <end position="659"/>
        </location>
    </feature>
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        <location>
            <begin position="695"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="755"/>
            <end position="773"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1273185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="776" mass="87649" checksum="69903C6AB4D6180E" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CQI2</accession>
    <name>A0A812CQI2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CYP7A1</fullName>
            <ecNumber evidence="6">1.14.14.23</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SPHA_38830</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Farmed</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.23" evidence="6"/>
    <dbReference type="EMBL" id="CAHIKZ030001781">
        <property type="protein sequence ID" value="CAE1274367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CQI2"/>
    <dbReference type="OrthoDB" id="6692864at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008123">
        <property type="term" value="F:cholesterol 7-alpha-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006699">
        <property type="term" value="P:bile acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042632">
        <property type="term" value="P:cholesterol homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050529">
        <property type="entry name" value="CYP450_sterol_14alpha_dmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304:SF4">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0753">Steroid metabolism</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAE1274367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="229" mass="27188" checksum="C6F878970A45E77A" modified="2021-09-29" version="1">MIYMRYFIRRRRDGEPDIVPGHFLWGNGESFQKNAVDFLHQCRKNHGEIFTIRFFHQRLTIIMDPHSLEAMSKEHSVVQETLRMCSGVFMVRYVTEDCDFKMDNGEVYRIRKGDRVAIYPPAIHKDPEIFEDPLTYKFDRFIDAKFYKNNKEIKNPVLTFGTLCPGKRYALLQAKWYIFSQMNKFKMSLAAGQKAEMDINYHGHEILPPVKDIDIHFKLREGHQEITMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CU94</accession>
    <name>A0A812CU94_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_40045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001885">
        <property type="protein sequence ID" value="CAE1276483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CU94"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1276483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="277" mass="32908" checksum="6D80594AC7F3F093" modified="2021-09-29" version="1">MPVYFPRLVLFISAVPMTRRRPDTASQPEILGSTSKLPAIYIPRYLISFILHSLIILINLIIYLSIYLSIYLSIYLSISACVYKYQPVYYLSIYLYVSIYLNLFINMYICPYLSIYLSIYLSIYLSIYLSISACVYKYQPVYYLSIYLYVSIYLNLFINMYICPYLSIYLSIYLSIYLSISACVYKYQPVYYLSIYLYVSIYLNLFINMYIYLSIYLSIYLSIYLSLLNYRKVLIQTTFLQSVFYLSIYLSIYLSIYLSQSVYTHISLFVTYLSTDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CUW1</accession>
    <name>A0A812CUW1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_41489</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001993">
        <property type="protein sequence ID" value="CAE1278839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CUW1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1278839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="275" mass="34443" checksum="AE70897325283C2F" modified="2021-09-29" version="1">MRFFVVKLFLNSVHLLGRRHFKHCLFFFFFFFFFFSSFFFPLRSFCSFCVVSFLFFLSFFSFFSFFLPSSLKSLIFYLFFFFFLSFFSFFLSFFLSFLLFFFSFFLSFFLKASSLYLFFFLSFFLFLHLFLSFFIFFIFFFFFLSFFLSFSFIFISFFQPSSFKNLIFISFLFSFFLSFFFFLFFLFLFLSFFIFSFFHLYIFSFFYLSFFLSFFLSFFLSFIFFFLFFLSFFLLLLKPSSFKNLSFFFSFFLSYSFFFLSFLLFFLSFFSTIIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CV38</accession>
    <name>A0A812CV38_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SLC26A1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_41600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002002">
        <property type="protein sequence ID" value="CAE1279055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CV38"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1279055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="173" mass="20396" checksum="E0E323E44BC5F046" modified="2021-09-29" version="1">MLLYFFLPFDFFLPFFLQFGFFLSFVSFSVSSLYFLSVIALYVSYIFPSMFFSPAFFPIFLFLFLFSSFYLISFTFLFILSFLPSFHPVLFIYISFFANLILCLCLSIKHLSPLFLPSIRFPSFMSFGSFASFPYFLLCYFISFHNTAAMASLISQSKMQKQRPPLHISQKYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CXU4</accession>
    <name>A0A812CXU4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_42169</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002046">
        <property type="protein sequence ID" value="CAE1280164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CXU4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1280164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="245" mass="29550" checksum="EB58AFC1BFEE4A0C" modified="2021-09-29" version="1">MVFHYLSIYLSIYLSIYLWFSIIYLSIYLSIYLSIYLSIYGFPLSIYLSIYLSIYLSIYLSSPSDFLWPDSGEQIVISIYLSIYLSIYLSIYLSIYLSEYKTIDISIYLSIYLFRFLSIYLSIYIYIYIYTFSLKLGIKLSIDLSIYVFYLFIYLSIYLSIYLSIYIPFSIYLSIYLSIYIYTFSLKLALKFSIYLSIYLSIYIYIYIFSLKLGIKIRYKTIYRSSFIYLSTQQVVLECKFKWFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CYM6</accession>
    <name>A0A812CYM6_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cilia- and flagella-associated protein 99</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_45712</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002368">
        <property type="protein sequence ID" value="CAE1285943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CYM6"/>
    <dbReference type="OrthoDB" id="10262255at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039341">
        <property type="entry name" value="CFAP99"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34649">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 99"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34649:SF1">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 99"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="330"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1285943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="604" mass="71083" checksum="AD85BE03F6DC7D25" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CZQ3</accession>
    <name>A0A812CZQ3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_46233</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002439">
        <property type="protein sequence ID" value="CAE1286888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CZQ3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1286888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="281" mass="33381" checksum="54E53074736457DA" modified="2021-09-29" version="1">MLFFNNFHFLSSSIHIAFFLPSFHSFYSLPSFLPSFTFLSSAFTSHYIFFYIFSFLSFSSISLSLSKSFLLILFFFRSPPTFFFFFFYIFSSLSHSFFLQSLFSSRPSFSFCVCIILFLSRILSFSFCFSHPLFPSHSFSLSLSFSFFSLNLSCFLILSFSTSSFFFFFTYFLLFLIFSLHNLSSRLAHLSSHSLNQSFLSFLLFYFRSFFFILLLISLYFCLFLSTLSLFLLHLKNSFFSLFSFRFSFFRLSAFLSLFHSVFNFCCFSFVRHIFFFSLCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D1Q3</accession>
    <name>A0A812D1Q3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_44339</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002267">
        <property type="protein sequence ID" value="CAE1283930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D1Q3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1283930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="205" mass="22804" checksum="4DDC46F4C336657B" modified="2021-09-29" version="1">MDDDSAFLSLPSLSLSPLFSLSLLLSHFLSLCLSSSLPFPSLSFSLSFFHSLSHFLSPSHVLAFSLPVLLIHIKVHQTKVLGRCPRCFSNSSSISFLFPSFPLSSLFLSLSLSLTRLLSLPLSLSLLFPLLSLSRSLFISFSLPFISFFLLFLPLSFDRNSSPKITVSPPTRRLFALSSTRSPSGHHRWLPNLTAELYLIRQNVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D208</accession>
    <name>A0A812D208_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_48639</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002722">
        <property type="protein sequence ID" value="CAE1291156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D208"/>
    <dbReference type="OrthoDB" id="2289094at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="428"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="23"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="457"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="534"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="642"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="737"/>
            <end position="797"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1291156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="961" mass="112826" checksum="1D55FD6B65EFFCDB" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D326</accession>
    <name>A0A812D326_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_46212</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002434">
        <property type="protein sequence ID" value="CAE1286828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D326"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1286828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="235" mass="28741" checksum="473CE03599EFD8F8" modified="2021-09-29" version="1">MFIIYLSIYLSIYLTLFLIYMFIFYLSIYLSIYFIFDLTQYVHLSIYLSIYLSISLYFDLCYYLSIFYLYLQYVHYLSIYIYLSILILPSIMFIIYYLSIYLIYFIYLSIYLSIYLSHFILILPSMFIIIYLSIYLSIYLSIYLSIYRFIFDLTLTLFLIFLILLSIYLSVIYLFRLFLSYLSIYLSIYLSISIFTFFILPSMFIIYLSIYLSIYLSIYLALFLILLSRYFLILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D3T7</accession>
    <name>A0A812D3T7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_49454</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002833">
        <property type="protein sequence ID" value="CAE1292784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D3T7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="327"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1292784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="372" mass="46513" checksum="2277C134B4A09D27" modified="2021-09-29" version="1">MFLYFYACNRLPSRSFHCIIEENDAIFKPMRFFNSQISIYLSIYLSIYLSIYLSIYLSTLSLDRDRAISIYLSIYLSIIKTFSLKIHIPCYIIPSILLIISLCQEHFYRLKMNITFQSCIFYDYYFPSIYLSIYLSIYLSNKRIYMALKTLYFFRCFLFLSNQPFFLFSFSFFLLSFFFFSFILFSFLFFFLSFSFFFRSFFFSFFLSFFFLFSFFSFLYFFFLSFFFSFLFFLFSFLFFPFLFSFFFLSFFFPFLLSFFFRSFFFSFFLFSFFFFLFSFFFLFFLSIFFLFSFLSFFFLSFSFFFLFSFLSFFFLFFLFPFFFLFFFSFFFSFFFLFFLFPFPFFFFLFYNSNYIDLMTTSVYFLSFHTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D5M8</accession>
    <name>A0A812D5M8_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">L-gulonate 3-dehydrogenase</fullName>
            <ecNumber evidence="8">1.1.1.45</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">L-gulonate 3-dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SPHA_47942</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Farmed</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.45" evidence="8"/>
    <dbReference type="EMBL" id="CAHIKZ030002644">
        <property type="protein sequence ID" value="CAE1289983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D5M8"/>
    <dbReference type="OrthoDB" id="2021159at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050104">
        <property type="term" value="F:L-gulonate 3-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000356">
        <property type="entry name" value="Lambda-crystallin homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022694">
        <property type="entry name" value="3-OHacyl-CoA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075">
        <property type="entry name" value="3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075:SF1">
        <property type="entry name" value="LAMBDA-CRYSTALLIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000105">
        <property type="entry name" value="HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase NAD binding" evidence="12">
        <location>
            <begin position="5"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase C-terminal" evidence="11">
        <location>
            <begin position="189"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="10">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAE1289983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="313" mass="35442" checksum="FB98783B27691B2F" modified="2021-09-29" version="1">MARGKIAIIGSGLIGGSWAMIFLSKGYNVSMFDVDEVQLAAAQKKIPENLKRFESQGNLRGEISADEQIKLITFTSDFAECIKDAIYVQECVPEKLELKRKIFEDLDKLCTDDMILASSASCIASSRFNYGLKHAKNMLIVHPVNPPYFVPLVEIIPSDQTRPEIVTKTRQLMEEVGQAPITLKKEIIGFALNRIQYAILNECWNMVQADLLNAEDIDRVMVHGLGMRYAFIGPLETMHLNAEGIVNYCDRYAAGALKVSETFQPPPLYDIPTAEKLNEYFSEHIPLEKLEERRKWRDECLAKLAKLKKEIPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D5Z0</accession>
    <name>A0A812D5Z0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_45894</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002397">
        <property type="protein sequence ID" value="CAE1286270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D5Z0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1286270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="173" mass="20391" checksum="0FAB02C2F864DD23" modified="2021-09-29" version="1">MSNSRFKRIFSFIHLSIYLSIYLSIYLSLSLSIYIYISVLLFHSFIHSFIHSFFLSFFLSFFLSFYLSIYLSRFIHIYLSIYLSIYLSIYLSAILGTILNGGKRLQHYLTQFVHIYLSIYLSIYLSIYLSIYLCLFILSIYLSIYLSIYLSIFDHELLSPTSVCPLLSLLPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D891</accession>
    <name>A0A812D891_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_48335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002678">
        <property type="protein sequence ID" value="CAE1290660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D891"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1290660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="212" mass="23959" checksum="1BBD762A2C29258C" modified="2021-09-29" version="1">MCTQAYGSFSLGHKAWFMCTRAHGSFSLGHKARFVCTQAYGSFSLGHKAWFMCTQAHGSFSLGHKAWFMCPQAYGSFSLGHKAWLMCTQAHGAFSLGHKAWFMCTQAYGSFSLGHKAWFMCNQAYGSYSLGHKSWFMCTRAHGSFSLGHKAWFMCTRAYGSFSLDHKAWLMCTQAYGSFFFRPQSMVHVCPAHGSFFFRPQSMCTQPMVLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D902</accession>
    <name>A0A812D902_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_49399</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002822">
        <property type="protein sequence ID" value="CAE1292694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D902"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1292694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="211" mass="25358" checksum="1ACC42D843C87C6D" modified="2021-09-29" version="1">MHIIYLSIYLSIFCRFTIFNYQHLFLSSLFLYSLYLIIFLFSFFLFQSVPIYLSIYPNLFISLSLNLFASIYLSIYLSIYLSIYLSKSIFCSLSIYLSIYLSIYLSNLDHYLSIYLSIYLSIYLSMFIFYSIYLSIYLSIYLSIYHNNNLSIYLSIYLSIYLSIYLSIYVYVFICIYVYVGMTGWIDLSIYLSIYLSIYLSIYLSFFFFKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D973</accession>
    <name>A0A812D973_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TTN</fullName>
            <ecNumber evidence="7">2.7.11.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SPHA_48399</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="7"/>
    <dbReference type="EMBL" id="CAHIKZ030002689">
        <property type="protein sequence ID" value="CAE1290796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D973"/>
    <dbReference type="OrthoDB" id="6157814at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098632">
        <property type="term" value="F:cell-cell adhesion mediator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070593">
        <property type="term" value="P:dendrite self-avoidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000425">
        <property type="entry name" value="Myosin light chain kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000032">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075">
        <property type="entry name" value="BASIGIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075:SF101">
        <property type="entry name" value="ZWEI IG DOMAIN PROTEIN ZIG-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="587"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="718"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAE1290796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="919" mass="103041" checksum="E8132C720DFDA474" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DAH1</accession>
    <name>A0A812DAH1_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">B box-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SPHA_49820</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002889">
        <property type="protein sequence ID" value="CAE1293467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DAH1"/>
    <dbReference type="OrthoDB" id="6049135at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060340">
        <property type="term" value="P:positive regulation of type I interferon-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF299">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="108"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="4">
        <location>
            <begin position="173"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="4">
        <location>
            <begin position="238"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="284"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAE1293467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="766" mass="88368" checksum="ACD60D39D8E9E5C9" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DB97</accession>
    <name>A0A812DB97_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_49198</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002790">
        <property type="protein sequence ID" value="CAE1292283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DB97"/>
    <dbReference type="OrthoDB" id="6074510at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="AntiFam" id="ANF00005">
        <property type="entry name" value="Antisense to 23S rRNA"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1292283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="315" mass="35121" checksum="2A1304D0738B279C" modified="2021-09-29" version="1">MDRTVSRRSEPSSRTALMGEQPNPWNILQPQVAKSRHRGAKPSRRFATTDFFATLCPLCFKVHLLAAYLLPKLRYQFAEFLQDTSLKRLGILYLTTCVGTSNTRLRTYNTRDPSHITVPTNINVVPIDYALRLALGAGLTCADERCAGTLGLSARGHLTPLTLLMSAFALLIPPRPITRHLHRLTERSLPRDQRSNPGFDRFGDLSWRSGLFPSSRRTLAPAVCLPRLFRFRSPLLTESRLMSFPPGTEMFQFSGFASKPMYSVYLNTLRPTHSVRSVQPSGQLIKRIAPEISQAITSFAAPVSSPGIHPSSSTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DBQ2</accession>
    <name>A0A812DBQ2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_50816</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003021">
        <property type="protein sequence ID" value="CAE1295250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DBQ2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="394"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="422"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="465"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1295250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="498" mass="57371" checksum="F74AF2CE7F55AA21" modified="2021-09-29" version="1">MCLTATPSPTSFIFTVSCSRQSNISFLLSLFLSHPHTLSLSHFLKLLLILTLLFFLSLSFCFYDSDNLFFSFFLSPLFSPSFFLFFFLSFFLDFFLDFFLSFHNAALSLSLSLLSNRLVLSLSLSLSLFLSLSSNYLSLELSHSPSQIQFIEPPPSQHITPSLSVSFFPALTLCFSYLLISIYLSTVCNLSIYLSIYLSIYLSIYLSIYLSQAAVYLSIYLSIYLSIYLSQAAVYLSIYLYLSIYLSIYLSICAALALSLFLSVYTSSSSLSRCLRLSLHLCFLIPFFSTFSSTLSLPFTLFSFTFLYSRYFLSRRPLFLFLLLIYFSLSLFLHLFFYSFLSFFLSFSHNTLSLSLLFPFLSHYFDVYLYTCSIYLLLSQHLSLFSSLSSTLSFSLYTFFSLSLPLLFPTLYLSLHLSFSFLSLPLSLFLHPFFFFLSVSLTLFLHPSTHLPFFLYIYFSFYPTLYFPFISLTLLLSLSTPVPLFLFPSLFLSLSRHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DH74</accession>
    <name>A0A812DH74_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_55227</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003660">
        <property type="protein sequence ID" value="CAE1302839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DH74"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1302839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="187" mass="21591" checksum="EE6C0FD95619BC5B" modified="2021-09-29" version="1">MELNTKSNLSPPEISFSIHYLSIYLSIYLFIYLSKSVHYLFITVSCSLSIYLSIYLSIYLSKSLHYLSIYLSICFSLFIMYQSTYINLFIFYLSISIYLSLFIFYLSIYLSIYLFSLSIYLSLFISIYLSQSVPYLSIYLSISAAPLAFISVPLEPVSGKSTRCERLASICNRLDNRVQRTNASMLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DJX3</accession>
    <name>A0A812DJX3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_54454</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003537">
        <property type="protein sequence ID" value="CAE1301479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DJX3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="287"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="319"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="381"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="409"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="438"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="471"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="498"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="526"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="596"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="679"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1301479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="710" mass="82923" checksum="54CCC9D1CE5BA5D8" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DL74</accession>
    <name>A0A812DL74_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_56456</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003723">
        <property type="protein sequence ID" value="CAE1303616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DL74"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1303616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="311" mass="34588" checksum="235AA48E6A01ACE2" modified="2021-09-29" version="1">MISLFRKVLFFIYKSPNTRLGRNIAIVFCLILLFLHHFSLLSLSLLSFFLSFFLSFFCVCFSPLSTSFILTSFFLSFFSNFFRYFSLLTFPPFFYINFPATLSLSLSLSLSLSFFSLFPFSLSFSLSPLISLLHALSFSLSLCFSLSVFLSFSLCLSPSVFLSLLLTLSLLTLSLCCTLSLCCTLSLFTAHSLCYCSLSLCFSLTLSELLILSLCLSALLTHSISLCASHSLSLHLSLSMCFSLLLSLSLSQRFSLTLSLSALLTLSLHLSLSMCFSLLLSLSLSLRFFPSLSLSLSLPLSLRCSLTEHPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DMM7</accession>
    <name>A0A812DMM7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_54561</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003547">
        <property type="protein sequence ID" value="CAE1301669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DMM7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
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        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1301669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="286" mass="34738" checksum="E00896F48771A2BA" modified="2021-09-29" version="1">MARRLSSFPVPSFSLLFFPLLIFLTFFFSSLCTLFPLLSSHCYSTLFFSFFIFFPFSPFYLFTLSTFFLVFLFCSFFISFFLSFFFSFPFPSLYSPLLFLFFLPFFSFFPSFLFALLFFISLLLFLLILQLHFFSRLILLFFPLLSRLSFLSPDGIFFFLSIFYSFFLRFAQLFFYFLFSSLFQETFINSFFLSFFLSYSKRPSFFLSFFDLFLSFLFQEIDFLSFFLSFFLSFFLSYSKPSFFLSFFLSFFLSFLFEVTLFLFILFRKTFFLSFFLSYHDNKYAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DNE8</accession>
    <name>A0A812DNE8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ANOS1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SPHA_59466</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004120">
        <property type="protein sequence ID" value="CAE1307433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DNE8"/>
    <dbReference type="OrthoDB" id="9985779at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050991">
        <property type="entry name" value="ECM_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46708:SF2">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46708">
        <property type="entry name" value="TENASCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    </evidence>
    <sequence length="418" mass="47583" checksum="6655E148325E6013" modified="2021-09-29" version="1">MYHKSIYFFLFQIFYSKTSPEYSNLEEHQKTVHGDRHSLTLKDLQPGTQYLVQIQAIIQVGKKRYRSTKESMHMVTDPVDALHIRSQHNIKVQNLTVGTPYFHKGNLKAQVYWNIAPGKGHKISKYLIYWQSTDNCQKHSKNWKLLTMDEKQEAFSRNTNFELYHLIYDCQYQVDVSAVNLDGQQGALVSTNFTTPPCEDIVVKGSVEIECPIGEYYSTFLNAVDTHTHTLSLSLSLSLSEMFRMPLPPGRPAKPTYLLHTNNGISIEVLWKRPVSYYPIIRYLVHLVMVGDNVADKEPPIVLGLNSNCTEVVVNATMPANQTKFRFNNLRENTQYIVFIYADSKVGRSQPTKISVKTPVLKTYLLDTSPRKSDFSTSQNPEGTYDSTSAQRGDTCSLSVMSVYQLLVTASLLCLLIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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                <person name="Bekaert M."/>
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        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <sequence length="2690" mass="319013" checksum="CA0291636E350341" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DSG7</accession>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1307515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="159" mass="18275" checksum="A6BD747A464F44A9" modified="2021-09-29" version="1">MTSEDPNDLEISESEISDLVPNFRGLYSLCFHSKCQHPPLNNEDDIRELFSPVAPIADITDYKGLQFVRFSTKELAIKALKAFRTKLQIKVADQKKNSTIESPNSDVRNHIRTNKRTTNKHSHNHSSRNSSDGILMYMGNIDVNSTEEEIQEFYQELIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DVT2</accession>
    <name>A0A812DVT2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_61236</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004316">
        <property type="protein sequence ID" value="CAE1309553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DVT2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1309553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="206" mass="23691" checksum="9C64794CD46CC11D" modified="2021-09-29" version="1">MPIHIPIYLSIYLSIFSFVDSSFLLFHSPTRAFRLYLLYPSRTRAVRLYLLYPSRTRAVRLYLLYPSRTRAVRPSATSLQDASGHGSICCILQDASGPGSLRTRAVRLYPSRTRAVRLIPPGRERLGFYLLYPSRTRLGSICCILQDHLRLPPSRTRAVERSAGSRTRAIAFLHIFFVCRFRFLNLCSSNFLVPKIPPFDYLSRSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DY88</accession>
    <name>A0A812DY88_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_60772</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004241">
        <property type="protein sequence ID" value="CAE1308937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DY88"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1308937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="160" mass="18282" checksum="DFE53BFCD3BEC901" modified="2021-09-29" version="1">MIIYIEEKLIRAEKCLSIPVRRFYFFEETIINTVFFIFIFLTRSFASHNTLSHSPSISLLLLLFHSLVLAYHSFAVSLSASLLLLLSLSLSLSLSLSLSLSFPLSVFTIVLSLSYNWSWVDTFSLSLFSLSYLLYSLSLTLSLLLFVLSYSLSFYRVLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E156</accession>
    <name>A0A812E156_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_66408</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004787">
        <property type="protein sequence ID" value="CAE1315454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E156"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="298"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="325"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="359"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="395"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="424"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="454"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="534"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="562"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="593"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="625"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1315454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="660" mass="80311" checksum="064741696A213C9C" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E189</accession>
    <name>A0A812E189_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Centrosome-associated FAM110 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SPHA_65285</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Farmed</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM110 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004708">
        <property type="protein sequence ID" value="CAE1314313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E189"/>
    <dbReference type="OrthoDB" id="10028183at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025740">
        <property type="entry name" value="FAM110"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025741">
        <property type="entry name" value="FAM110_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025739">
        <property type="entry name" value="FAM110_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14758">
        <property type="entry name" value="AGAP005440-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14758:SF1">
        <property type="entry name" value="CENTROSOME-ASSOCIATED FAM110 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14160">
        <property type="entry name" value="FAM110_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14161">
        <property type="entry name" value="FAM110_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Centrosome-associated FAM110 N-terminal" evidence="4">
        <location>
            <begin position="27"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="Centrosome-associated FAM110 C-terminal" evidence="3">
        <location>
            <begin position="236"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="290"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="299"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="312"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAE1314313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="345" mass="38828" checksum="B4E06346DFD512F3" modified="2021-09-29" version="1">MIATNPHFSERMSCINCGFHVFFFPAATPSNRRSAVELLEESKSQYVKSSSVLDTKQSLMQMATDNISSNRRLSHPVTNQPLRAKSEYDLSQLKTSEEFSSPSFLGCSNPSLMDIDCSTTESDGQLNQRLTNGVLKLDTSLRPTQQMDEMGSSIHSKSLPMTTSMIDQLEDLPLPNSATVDDIVDMLPEKITQHFQNPPLQRNSEGVVLRRQKRPIHRSQSDVTYLHTRTSDIPSMGSRLSRASVELEKFFNEMGIDRTILDPMLRQQEESVQKDADFFETLSSLDSPDTRSICSGISRSEKGQSDVETLDRQQNSPQNTSIVERNARIIKWLCNVKKARSQSAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E1A1</accession>
    <name>A0A812E1A1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_62569</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004482">
        <property type="protein sequence ID" value="CAE1311077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="8963674at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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        <location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
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        <location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        <location>
            <begin position="936"/>
            <end position="954"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1311077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="955" mass="109142" checksum="BE348DA6330ACDA9" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E2S6</accession>
    <name>A0A812E2S6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_67193</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="CAE1316517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
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            <end position="200"/>
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        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1316517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="238" mass="28364" checksum="FF16C1519065E7F1" modified="2021-09-29" version="1">MKLVDLLIIPLAFLYLISFVENQNLSIYLSIYLSIYLSIITLSTYLSISLSSYLSIYLSMFVYIYLSTYILPIYLSIYLSIYLSIYLSIYLSITLRSYLSDSSYLFIYIIQFLFISVLYLSIYLSIYLSIYLSIYLSHSFISIYLSIYLSNYLSIYLIHSYLSIYLSHSVDIYQLMSIYLDTYICIFHSVHIYLSIYLSIYLSIYLSIYLIQLISIFQFFNFLFLCYFPSFFCSKYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E347</accession>
    <name>A0A812E347_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
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        <dbReference type="NCBI Taxonomy" id="158019"/>
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                <person name="Bekaert M."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="1">Farmed</strain>
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    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="CAE1314658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E5A9</accession>
    <name>A0A812E5A9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNAH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_68059</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
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            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
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                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="CAE1317505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        </location>
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        </location>
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        </location>
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        <location>
            <begin position="1434"/>
            <end position="1466"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1317505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1472" mass="158251" checksum="40C3B3E1CDC91E42" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E5H0</accession>
    <name>A0A812E5H0_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4773 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SPHA_68452</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
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            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004980">
        <property type="protein sequence ID" value="CAE1317928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E5H0"/>
    <dbReference type="OrthoDB" id="5952164at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031941">
        <property type="entry name" value="DUF4773"/>
    </dbReference>
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        <property type="entry name" value="AGAP008005-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36299:SF2">
        <property type="entry name" value="DUF4773 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15998">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032493007" description="DUF4773 domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4773" evidence="3">
        <location>
            <begin position="51"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAE1317928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="262" mass="28907" checksum="4FCD236ED72A1F5C" modified="2021-09-29" version="1">MRHLLLLSLFFSISYFAKANISSDFRLVVAKCISQIQEAEKEASLHMTGGCSCANYSCGCCGHIEQSSLHLNDTGCLNITYIPEKFGISVKFTLDGSVIFSEEASASDPPPLCFGLPHLIGVGMCIKFYNLSLANHSFSGCVMVQLKGFVRDTYKLGCFKLHFPVNAAAAPLLADDRAMRLSQPPTNNLVVVAKKNPDMSLRFHTFFFISTFPLCITLSFSSYSFSLSFSLHLPLSLISIKRNIVLVASLFLSYIYCLFISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E6X7</accession>
    <name>A0A812E6X7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_69263</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005067">
        <property type="protein sequence ID" value="CAE1318802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E6X7"/>
    <dbReference type="OrthoDB" id="6268344at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="500"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="511"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="654"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="708"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="766"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="816"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="868"/>
            <end position="880"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1318802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="907" mass="102019" checksum="90B778C2A58E3B14" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E898</accession>
    <name>A0A812E898_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Synaptosomal-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SPHA_68551</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Synapse</location>
            <location evidence="6">Synaptosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the SNAP-25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004991">
        <property type="protein sequence ID" value="CAE1318054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E898"/>
    <dbReference type="OrthoDB" id="19261at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031629">
        <property type="term" value="P:synaptic vesicle fusion to presynaptic active zone membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016082">
        <property type="term" value="P:synaptic vesicle priming"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15885">
        <property type="entry name" value="SNARE_SNAP25C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15889">
        <property type="entry name" value="SNARE_SNAP25N_23N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000007">
        <property type="entry name" value="Synaptosomal-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000018">
        <property type="entry name" value="Synaptosomal-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000928">
        <property type="entry name" value="SNAP-25_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19305">
        <property type="entry name" value="SYNAPTOSOMAL ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19305:SF14">
        <property type="entry name" value="SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00835">
        <property type="entry name" value="SNAP-25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0770">Synapse</keyword>
    <keyword evidence="2" id="KW-0771">Synaptosome</keyword>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="10">
        <location>
            <begin position="22"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="10">
        <location>
            <begin position="147"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="109"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="53"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAE1318054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="449" mass="49671" checksum="F8548A9D899CD9BD" modified="2021-09-29" version="1">MSANGEMDVPKTELEEIQQQCNQTTDDSLESTRRMLNMCEESKEAGIRTLVMLDEQGEQLDRIEEGLDQINQDMRDAEKNLEGMEKCCGLCVLPWKRGKSFEKSGDYANTWKKDDDGPTNTNGPRVTVGDQNGMGPSSGYVTRITNDAREDEMENNMKEVSSMIGNLRNMAIDMGNEIGSQNRQVDRINKRPNPTRAVSTRLTRRLRNYLKIELSHLLNLSLPFPLPLSLPFPLPLSLSFSPVVSLVLSRCLSRSLPLSLSFSPVVSLVLSRCLSRSLSLSLVLSLSLSLSLVLSLSLSLSFSLSLVLSLSLSFSLVVSLSFSLSLSLSFSLSLSLVVSLSLSLSLSRCLSLSLSRCLSHSFSYHIPLLPIFPFSANIYPLPSSIPFPKYPFLPAFSPNIFSANIFPHPLPSSIPLPPTFPFSSNIYPFLPAFPFPQHFPFPSTSTPSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EAZ7</accession>
    <name>A0A812EAZ7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">HNRNPA1_3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SPHA_67904</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004924">
        <property type="protein sequence ID" value="CAE1317332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EAZ7"/>
    <dbReference type="OrthoDB" id="1875751at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000040">
        <property type="entry name" value="Heterogeneous nuclear ribonucleoprotein A2/B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48026:SF14">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48026">
        <property type="entry name" value="HOMOLOGOUS TO DROSOPHILA SQD (SQUID) PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="59"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="147"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="232"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="244"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="264"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="276"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAE1317332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="386" mass="41552" checksum="8856ECD16537BBDD" modified="2021-09-29" version="1">MQLNSYSTELSLISYTTRPLLGSFIQMYQWERSIYHKGAIMPESRGRYRDSDSDGEKFCKLFIGGLNYTTNEEAMKEYFEPWGEVVDCVVMRDPNTKKSRGFGFITYKTEEQVDEAQRNRPHNIDNKEVETKRAMPRNETDSQATVKKLFVGGIKEDTGEEEIREYFSAKGKIETIDMITDKGTGKKRGFCFITFEDYDTVDKLVLKKYLDFKGKRVEVKKALSRAEMNHNKQINMGPMGGPMGPGPMGPGPMGPGPHMGGPMGPGPHMGPPGPPGRGGRGGMGGGRGAGGDWHNSPGNYGYGGGGNFNGGYHQGPGNWGGRGGHPGYGGYGHQGNYGGGHGGYGNQHGGYGGGGGGYGQGGWNQGYEGFGGGYGGGSGYGGGYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EC84</accession>
    <name>A0A812EC84_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SPHA_69621</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005098">
        <property type="protein sequence ID" value="CAE1319217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EC84"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="284"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="385"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="421"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="449"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="478"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="508"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="535"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="562"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="596"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="623"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="652"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="680"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="704"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="735"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="767"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="22"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAE1319217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="788" mass="94826" checksum="1DA26246BB13C7E7" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EEA3</accession>
    <name>A0A812EEA3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_71964</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005280">
        <property type="protein sequence ID" value="CAE1321962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EEA3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1321962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="204" mass="22611" checksum="8F3C885A0DC4E6B5" modified="2021-09-29" version="1">MFCLISLSLSLDILHFLSLFLTLSLSLDILHFLSLSLSGHSTLPLSLSLWTFYTSSLSLSLWIFYTSSLSLSLDILHSLSLSLDILLSLSLSLSLWTFYTLSLSLSGHSTHSLSLSLDILHTLSLSLWTFYTLSLSGHSTLSLSLDILHFTSPLSLSLSMHSLFSLFLCLSFPLSLFSFVSLFLCLSFPLSLFSFVSLFLCLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EGH6</accession>
    <name>A0A812EGH6_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquitin carboxyl-terminal hydrolase MINDY</fullName>
            <ecNumber evidence="8">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SPHA_73925</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Farmed</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins.</text>
    </comment>
    <comment type="function">
        <text evidence="7">Probable hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the MINDY deubiquitinase family. FAM188 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="8"/>
    <dbReference type="EMBL" id="CAHIKZ030005400">
        <property type="protein sequence ID" value="CAE1324208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EGH6"/>
    <dbReference type="OrthoDB" id="10263628at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990380">
        <property type="term" value="F:K48-linked deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071108">
        <property type="term" value="P:protein K48-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025257">
        <property type="entry name" value="MINDY-3/4_CD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059022">
        <property type="entry name" value="MINDY4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039785">
        <property type="entry name" value="MINY3/4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12473">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE MINDY-4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12473:SF8">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE MINDY-4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26038">
        <property type="entry name" value="Dimer_MINDY4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13898">
        <property type="entry name" value="MINDY-3_4_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01174">
        <property type="entry name" value="DUF4205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="701"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="732"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="762"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="domain" description="Deubiquitinating enzyme MINDY-3/4 conserved" evidence="11">
        <location>
            <begin position="373"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="94"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="235"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="154"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="256"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAE1324208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="841" mass="92468" checksum="609D16BD7F47D896" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EIR3</accession>
    <name>A0A812EIR3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_74397</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005429">
        <property type="protein sequence ID" value="CAE1324684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EIR3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1324684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="200" mass="22013" checksum="A29ADF3457EC6E40" modified="2021-09-29" version="1">MNRHTYIPETSQRFLAGPGVQPGLRAGANFPKSFDHHSSLLPSLCDASTPAASSSLLQLIPAPSSTPAAFRSLLQHPALLQLPALSCSFRHSCSFQLAPAVYSSPLRRFTDVPRPIPAPADDLIQCPLTSSARYRPDTVQTTSVFFTIHRLQIKTRFPSSTTDRLRLSSFFAIVISLPLCPPFSCTVDWHSHLSARCNKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EKZ4</accession>
    <name>A0A812EKZ4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_75588</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005464">
        <property type="protein sequence ID" value="CAE1325960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EKZ4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1325960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="245" mass="28519" checksum="E06A4702BBB6C1B8" modified="2021-09-29" version="1">MSSIDEKPLSWFIRLIHDTCIHLNKSMLLLCLFHSNSTMSSIDEKPLSWFIRLIHDTCIHLNKSMLLLCLFHSNSTMSSIDEKPLSWFIRLIHDTCIHLNKSMLLLCLFHSNSTMSSIDEKPLSWFIRLIHDTCIHLNKSMLILCLFHSNSTMSSIDEKPLSWFIRLIHDTCIHLNKSMLLLCLFHSNSTMSSIDEKPLSWFIRLIHDTCIHLNKSMLLLCLFHSNSTMSSIDEKPCFMVHQTDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ET85</accession>
    <name>A0A812ET85_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_79955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005584">
        <property type="protein sequence ID" value="CAE1330663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ET85"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="298"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="331"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="355"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="383"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="411"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="443"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="471"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="502"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="527"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="556"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="586"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="615"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="670"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1330663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="714" mass="86300" checksum="BDBCF7C927410F1C" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EVT1</accession>
    <name>A0A812EVT1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_80362</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005598">
        <property type="protein sequence ID" value="CAE1331136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EVT1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="309"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="338"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="370"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="438"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="515"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1331136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="546" mass="64134" checksum="C77509DF77910CF7" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EW10</accession>
    <name>A0A812EW10_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_80876</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005612">
        <property type="protein sequence ID" value="CAE1331721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EW10"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1331721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="482" mass="54760" checksum="6DE67F071511CF3E" modified="2021-09-29" version="1">MSNLLSVLHTYLYVAQRLSFSLTFSKFLTFLSLNFLPLSLSPPTLSQISAFLTHSVSLSMKSLQFILLCLKSLYSSLSLYLSIYLSIYLSIYLSIYLSLCLSPFQSLIFPSGPKRKEILPIISIISTSRCLFPFSCVHLSVSFPISAPFFYFSLSLSLSLSLSLSLTLPPHREASSLTSKYLFLPLPLVLFLVFSLSLSLSLFLSFYFPFSLIPSLSYLSITALSNEKLPSSFPSSNTRIAIIPSSLPLFLIKTKLKMDTHALSCINSYREALLFLLFSGCVLKRTPRSCQPNEKTYFRRSLQLQTLVFRRLQQTTSAPICDPFLPTLNSFSHFVLCLFSPKPCLSVRPPISLYDFLILSLSLFFSLSLSLYFRFLTYCLFSSFAFSMYFKASHYYLPYLITISLFRVHHRVLHRVHHRLTIRTAVLFYHTQSNAHSVPVFSPSLSLSLSLSLSFDISHSFSFFLPSLFKSITKSHTTTCHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EW61</accession>
    <name>A0A812EW61_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_79798</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005578">
        <property type="protein sequence ID" value="CAE1330493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EW61"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="46"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="111"/>
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        <location>
            <begin position="118"/>
            <end position="139"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="183"/>
            <end position="210"/>
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            <end position="242"/>
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        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="350"/>
            <end position="369"/>
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        <location>
            <begin position="378"/>
            <end position="403"/>
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        <location>
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            <end position="427"/>
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    </feature>
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        <location>
            <begin position="434"/>
            <end position="458"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="464"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="492"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="518"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="544"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="574"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="603"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1330493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="640" mass="77141" checksum="9FE400ADE58A023B" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ALK5</accession>
    <name>A0A812ALK5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_1200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000033">
        <property type="protein sequence ID" value="CAE1143082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ALK5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
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        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1143082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="325" mass="39167" checksum="5663F1B8757B333A" modified="2021-09-29" version="1">MFTVSLFITPLSLSVINSWFSNSFSLSLSSHLFSLKYLSLSIFSFFCFVHLFPLSLPLSFFLSRSHLFFPFLYYFYSLFLSFFASFFFSLFFLFFSLFLCFFRHSFHFSFFLLRFSFFLFFIFLFYSFIFLLSFFLSFFLSFFLNIIPFRFFRRLFRLIFLLFLVFLSFFFFLSFFFFIFHLILFSFSHFLFILFVHHLITPFYSHPLSLSLSLSLSVFVSPLPPFLSFFLSFFLSFVLFSMSFSFLFLTFSSFYLFSICLVLFYSHLSLCFSLHLSLSFFLSFFLFFLSFFISFFCNFDIARIMNSFLHLLLLILSPPPPSSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AP15</accession>
    <name>A0A812AP15_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">EXD1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_4024</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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            <taxon>Decapodiformes</taxon>
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            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
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            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000123">
        <property type="protein sequence ID" value="CAE1153730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A812AP15"/>
    <dbReference type="OrthoDB" id="26838at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990923">
        <property type="term" value="C:PET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034587">
        <property type="term" value="P:piRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052144">
        <property type="entry name" value="piRNA_biogenesis_EXD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46628">
        <property type="entry name" value="PIRNA BIOGENESIS PROTEIN EXD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46628:SF1">
        <property type="entry name" value="PIRNA BIOGENESIS PROTEIN EXD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="124"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="446"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="404"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1153730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="521" mass="58999" checksum="38E00C26239D020F" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AQE9</accession>
    <name>A0A812AQE9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_3150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000091">
        <property type="protein sequence ID" value="CAE1151329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AQE9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1151329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="248" mass="29746" checksum="9B9F1591E458EA8D" modified="2021-09-29" version="1">MFFLSFFLSFFLSFFLSSSPHQLFLSVVKFASLMFFLSFFLSFFLSFFLSFFVPTPIVSFCCKIRFTDVLSFFLSFFLSFFFSFSSSHQLFLSVVKFASLMFFLSFFLSFFLSFFLSFFVPTPIVSFCCKIRFTDVLSFFLSFFLSFFLSFFFLRPTVIKIRLFLSLFLSFLFSFFLSFFLSFFLSFFLFFLSFFLSFFFLRPPHQLFLSVVKIPSLMFFLSFLSFFSFFLSFFVPHQLFLSVVKFLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ASM7</accession>
    <name>A0A812ASM7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_4302</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000134">
        <property type="protein sequence ID" value="CAE1154726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ASM7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1154726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="288" mass="34604" checksum="A0B14FE8527B842D" modified="2021-09-29" version="1">MQKYLKSLSFSFNFFCTILSFSLFFFFFFSLSFSQGSFSRPFSLFPSLFFFHSHKPIFLFIFFSFSISQALLFLLMSLFFFPHSHKRFFSLHFSIFPFLFLTSPPPPSPHFPLLLFLTSVATLHLSLIFSLCFYQFLSIFITLCHKPPFLIFFFFLCRFITRLRFSSFNLFLFLSFYFFLLFFLFLFSQAFLSLVYSILYLFLTSFRFSFFSFFHFHKPRFSSFFFLFSISFLQSTFLFFFPSSLILTSRSFSSFFSFLCVFLTSLIRLISFCIISFSTSLSLFFLYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AXV8</accession>
    <name>A0A812AXV8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_8978</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000289">
        <property type="protein sequence ID" value="CAE1166611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AXV8"/>
    <dbReference type="OrthoDB" id="1421090at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1166611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="238" mass="27938" checksum="51DD4CEC4B091129" modified="2021-09-29" version="1">MLSSQWRYLSLIGGKIQCTDESIYLSIYLSIYLSIIYSKFFSLFISIYLSIYLHHPLSFSVCLGLSIYLSIYLSIYFHHTLSIHMSLFRSIYLSIYLSPLHSLYFSLFRSIYLSIYLSIYTEAPDQIWQRFQCTDLSIYLSIYLSIYLSIYHLFISIYLSIYLSIYLSSSPSLFFSLLRSVCLSIYLSIYLSIYLSIYLSSSHSLCFSLFRSIYLILFISIYLCSDLSICLSIVFLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B0N2</accession>
    <name>A0A812B0N2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_7227</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000234">
        <property type="protein sequence ID" value="CAE1162338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B0N2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032480355" evidence="2">
        <location>
            <begin position="17"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1162338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="310" mass="37091" checksum="E01C2906DDDC78F0" modified="2021-09-29" version="1">MFFSLLLICLYPSVSLLSIISLSFSSPKSLFTQFLSFSSLFLLSSFPMKNAISQYMCFFFFYLSILCHLFLSLKHIFFLFIIFSIFWNKIFLSMSFFSLELYFSHFLIYSFKIMLSFSLTFLFSLLFSISLNLSYHLFFVFLFSPFLFFCFLSLISSSFFTLSHFYSLFLKHFSFLKLMTLSIYFSLSHYFTFRLFCSYLFLSFSVTTLLPFFINLTFYLSLSNQIPFYFTISIFVYFTIYPPMFFLFYLAYLSFFFLFLFVISSFLNRAFFSISFQFHSVLIHFFFSSIIHPLSGPVCLSLSSFHFERY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B0V8</accession>
    <name>A0A812B0V8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_8243</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000268">
        <property type="protein sequence ID" value="CAE1164935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B0V8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="296"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="325"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="363"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="385"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1164935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="497" mass="58979" checksum="38D7FB4EDF10CAFC" modified="2021-09-29" version="1">MSIIDTFIYLSISIISTLSISKIDTFIYLSISIIGTSSISIMDTIIYLSISIIGTLSISIIDNFIYLPISIIGTFIYLSISIRGTFIHLSICIIGTLSISIIGTLSISIIGTFIYLSLSIIGTLSISIIGTFIYLSISIIGTFIYLSISIIGTSSISKIGTIIYLSISIIGTLSISIIGTLSISIIGTFIYLSISILVTLSISIIGTFIYLSISIIGTLSISILDTFIYLSISIIGTISMSIIGTFIYLSISIIGTCIYLSISIIGTLSISIIGTFIYLFIYIYNRHLIYIYNRHLYLFIYMYNRHLIYIYNRLLYLFIHIYNRHLYLFIYIYNRYLIYIYNRHLYLFTYIYNRHLIYIYNRHLYLFIHIYISNLIYIYNRHLYLFIYIYNRHLIYIYNRHLYLFIYIYNRHLIYIYNRHLYLFIYIYNRHFYLFIHIYNSNLIYIYNRHLYLFIYIYNRHLIYIYNRPLYSFIHIYNRNLIYIYNRHLYLFIYLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B203</accession>
    <name>A0A812B203_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_8823</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000286">
        <property type="protein sequence ID" value="CAE1166356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B203"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1166356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="275" mass="31351" checksum="0C95EEB337BB1DD2" modified="2021-09-29" version="1">MSKNHSIYLSIYIILFISIYPSSYPTTPFFLSYLSIYLSIYLSIYLSIYLGLFISIYLGLFISIYLSIYLSIYLMLPLADVWQYALEKFPFFCSLSLSLSLSRSLSLSRSLSLSLSLSLSLVDSITLSKIPSFFFSPFHIYLSIYLSIYLSIYLCTLLIRFLLLFSSSSSSPPPPPPTSSSSSSFSSYITTTFDTSTHISYFSSLSSFCLHFIFIIFHLFFLYSLNISLSVEMTKLHFFLFLFSFHVPLAPLSLSLSRSLSLRKATLLPLPFLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B2F9</accession>
    <name>A0A812B2F9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_8874</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="CAE1166399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A812B2F9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
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        <location>
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        <source>
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        <source>
            <dbReference type="EMBL" id="CAE1166399.1"/>
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    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
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    <sequence length="1198" mass="145481" checksum="6DA98CBB1AC63ED3" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
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        </submittedName>
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            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">Farmed</strain>
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    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
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        </submittedName>
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            <strain evidence="2">Farmed</strain>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="310" mass="34423" checksum="00C6DDB1A0749203" modified="2021-09-29" version="1">MLSFLIFFSFVLTLTFTLFYFNFLPLSLFLSFINSYSPSLLFCFLIFSFLSHSPFLLSLSLSLTFCNQLYLFVVLVYKNMNCRHYLHMPDILSYTFIYSCLPLSTRWSVCLFSVVSLSLRWSVCLFCQSVSSRWSVCLFSVVSLSLLGGQSVSSRWSVCLFSVVSLSLLGGQSVSSRWSVCLFSVVSLSLLGGQSVSSRWSVCLFSVVSLSLLGGQSVSSRWSVCLFSVVSLSLLVVSLSLLSVCLFSVVLSVSSRWSVCLFSVVSLSFSVVKDGQFQSVSSKSVSSRWSVFFSLGGQSDKCLFQFITSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="7" xmlns="https://uniprot.org/uniprot">
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    <name>A0A812B4C4_ACAPH</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">Farmed</strain>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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            <begin position="215"/>
            <end position="250"/>
        </location>
    </feature>
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            <begin position="230"/>
            <end position="239"/>
        </location>
    </feature>
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        <location>
            <begin position="240"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAE1167757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="250" mass="27760" checksum="16FB3C8D7B9AF99E" modified="2021-09-29" version="1">MMEARGLQGNVDLEEALSHYDKVLEAKASTLKKVDKKTLIDLDNWYQHELPVAIQERKIKCITHAELCKLMKWKLMRGKFRPKLTEMVESNKPQSVLDASQSAFDLLPDVEQALKALTVLKAVGPATASAILAAGAPDQVPFMADESMLAALPGRPKAYTLPYFLDYLDAVKNLVKQLNKDSGVSKDSMWTPHKVELALWSKSVTASLGISLGVQPAAPPEKKRRRVNVERNSVQNGTKTRGEKNKLQEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B4Z9</accession>
    <name>A0A812B4Z9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">SPHA_11535</name>
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    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
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    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000380">
        <property type="protein sequence ID" value="CAE1171332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B4Z9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAE1171332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="367" mass="43960" checksum="7FD829F2E05F491F" modified="2021-09-29" version="1">MLQTFHISIYPSIYLLLLFILSIYLASNFPFYLSIYLSIYLSTFFISIYLSVQTFHIYLSIYLSIYLLQTFHIYLSIYSNLSISIYLSIYLSIYLYQTFHIYLLQTFHIYLSIYLSIYLSTSNFFISIYLLTFHIYLSIYLYIYFSYLSASNYLSIYLFIYLSIYLSIYLSASNFYLSIYLSICFKLFYISIYLLQIFHIYLSIYPSIYLSIYLSIYLSIYLSIFKLSIYLSASKLFMLSIYLSISLLQTFHLSIYLSASFIYLSIYLSIYLHLSIYLSIYLSIYLLYLSIYLLQTFPYLSIYLSIYLSIYFSNCFKLFYLSASKPFISIYLSAIYLSIYLSIYLFIYLSIYLSICFRLFISIYLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B5I5</accession>
    <name>A0A812B5I5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">SPHA_10242</name>
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    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Coleoidea</taxon>
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            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">Farmed</strain>
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    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="protein sequence ID" value="CAE1168766.1"/>
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    </dbReference>
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            <end position="60"/>
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        <location>
            <begin position="158"/>
            <end position="189"/>
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    </feature>
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        </source>
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        <source>
            <dbReference type="EMBL" id="CAE1168766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="191" mass="22046" checksum="EDF83268846428A8" modified="2021-09-29" version="1">MYSFFLSFFLSVSLSLSLSVSLFHIASYFLSFSIHFSLPFFCSFVSLFFFCTTNISSLFFSLSLSLSLSLLISDTQISFSFSFNIFASRRTRKYLPVRRPLAHLPKATVAPSPLRLCTARKVVYPVVAAFCAEPRADRRMGGRRGLIRRHKRRTVWKYLSICLSIYLSIYLSISLSLSLSIYIYIYIYIYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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    <name>A0A812B661_ACAPH</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
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        <name type="scientific">Acanthosepion pharaonis</name>
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        <source>
            <strain evidence="3">Farmed</strain>
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    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <source>
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            <dbReference type="EMBL" id="CAE1171153.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="2016" mass="235605" checksum="78F0AFFE396113A1" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B7J0</accession>
    <name>A0A812B7J0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">SPHA_12408</name>
    </gene>
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        <name type="scientific">Acanthosepion pharaonis</name>
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        <dbReference type="NCBI Taxonomy" id="158019"/>
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                <person name="Bekaert M."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">Farmed</strain>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <source>
            <dbReference type="EMBL" id="CAE1173045.1"/>
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    </evidence>
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        <source>
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    <sequence length="198" mass="24329" checksum="5B66972A26F5BEDA" modified="2021-09-29" version="1">MIYISSIYLILSIYYLIHIYHLFIYLKYLSMISIHLSIKKYDIFHSYYHISIYYLIFIYHSSIYMFTSIHYSSYIIHISFIYNLFNISGYLLLIHLSIIYLSIYLSIYANHYIYIYIEISFIYLYIYKSIISIYLSIYLSFSFISYSSIYLIYLSIHMNYFSSFILFIYLFIYLSIYQYPSIYLSIHLYLSIYLIMNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BF27</accession>
    <name>A0A812BF27_ACAPH</name>
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        <submittedName>
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    </protein>
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    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
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        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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            <taxon>Decapodiformes</taxon>
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                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">Farmed</strain>
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    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="305"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="329"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1227194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="354" mass="41112" checksum="8A7B5132808F9C0A" modified="2021-09-29" version="1">MPASVPVRLPLLSLRLSLSLSFSLSLSLSLSLSLPLSPLSLPSLSISLLSPPLSHSHSLPLSLPLSLSLCKGLISRKNESINCFLSLLYIFFFLFFFYILSIFFSFLFFFLSLHLLSLLLSLLLYVFFYLLFQFCLSVRYYSLLFFSLFILPPLILASIPPFRIFLSPSLSYFFKSLPFVFLSPSLSYFFKSPPFSLPSTLFSPYLLSVLLSFYVTSFKYFFSFPPLPPFSFFKFFLSFLTSFSPLSFHPFFCFIPFFSSLWLCKPPSVNFSFFFFLSFLPFVPFLQFFFLFLSSFPSFCFKPPPTILFLFSFLSFLLSVFLSNFLHLFFSFFLSFLFFSVPSLLSFFIFFLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BFD9</accession>
    <name>A0A812BFD9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_15099</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000522">
        <property type="protein sequence ID" value="CAE1178255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BFD9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1178255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="390" mass="44336" checksum="83CD032A55084787" modified="2021-09-29" version="1">MNVFLSKDFLAVIQSSNGDIHGVIETGLQQSVGRCSACSEHYIAFTSVKGVGPILIDIETCTVIHRMEYYTQAMTFSRDESHFALYTGNRIILFSIPCFERKGTVKMEEFPKQLMLSLDSKKCFSLSRTGVVAVSRFDWKRRDSSIQEVFYHVDLQQMTLSEKGDKILFRSSKKLFLCQVQSPNTVNCLEFPTEILIATLSYFVDAAFSVTDDFVVGLRWTYVGVWETRTSSIVRVLKTSDNSPFKRLFVPQTGFEFYTLTNHKLELWDLALIQSDVQFKPNVFSNAVRAMALSANGERVICCTHRSPEAKVLGVQTDTVLFCLLHGHRSLNEVTHVEISPDAQFAVTFSNRNLFENGEDGDACHFLKECILWDIKTSNPKKLQHFESCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BFN0</accession>
    <name>A0A812BFN0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_15940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000557">
        <property type="protein sequence ID" value="CAE1226225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032789138" evidence="1">
        <location>
            <begin position="28"/>
            <end position="1734"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1226225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1734" mass="189566" checksum="E46D183087E1DED6" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BFP4</accession>
    <name>A0A812BFP4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_17636</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000630">
        <property type="protein sequence ID" value="CAE1230261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BFP4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1230261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="243" mass="29539" checksum="01FC20CA7C6D8E18" modified="2021-09-29" version="1">MRIFLLLFYSYRRIAKIFIRSQSFLYFLCYFFFFFCFFFLWIIYAISLFHSFLFSPWLFALFHSRLCLFSRAIELFFSLILLLLFFTFFLLLSLFFFPFIFLSLSLLLSLFFLFPFPFSLSVPFLFPFLSFSLFFPFLFLFLFPFPLSFRSLSLSVLFSFSFSFAFSFLSLSVLFFFPIPFPFLFSFPFSFSFRSLYLFVLFLFSFSFSFLFSFSFPFSFSFPFSFLFSLFSFLFSLFFPSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BG39</accession>
    <name>A0A812BG39_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_16832</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000596">
        <property type="protein sequence ID" value="CAE1228490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BG39"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="299"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1228490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="330" mass="38527" checksum="4CD01024C1CF8DB0" modified="2021-09-29" version="1">MYILFVQPISEGSYLSIYLSIYLSISFFLEESMFIYLSIYLSVRSYLSIYQFVYIYLSIRSYLSIYLSIYLSIYLLLSIIYLSIYLSPSVHLSISLFKSIYLSPSVYYLSIHLSIPFCPSIYQSVHIYLSISFCLLSIYPSIYPLLSIYLSVCSYLSIYLLLSIIYLSIYLSPSVHLSISLFISIYLSIYLSIYLSIYLSHSIYLSSYLSIPFCLSIYLSIYLSIYLSIYLSIYLSIYQSVYIYLSISVKTPFHHLPIYLSLQSIDLSIYLFLIISIYLSISFVHIYVSLFIYIYLKSLIYLSIYLSVCLSVCLSVMKKDYSLFFFGSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BJC8</accession>
    <name>A0A812BJC8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_17790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000636">
        <property type="protein sequence ID" value="CAE1230620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BJC8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="139"/>
            <end position="160"/>
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            <end position="291"/>
        </location>
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        <location>
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            <end position="380"/>
        </location>
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            <end position="413"/>
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    </feature>
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            <end position="445"/>
        </location>
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            <end position="508"/>
        </location>
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            <end position="533"/>
        </location>
    </feature>
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        <location>
            <begin position="563"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="594"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="624"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="686"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1230620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="736" mass="90295" checksum="6779DE6C73562F84" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BJY8</accession>
    <name>A0A812BJY8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_18009</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000646">
        <property type="protein sequence ID" value="CAE1231155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BJY8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="145"/>
        </location>
    </feature>
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        <location>
            <begin position="152"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1231155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="327" mass="40733" checksum="CC56A3986CEAC2D8" modified="2021-09-29" version="1">MKTSFSCFSFVSFISLYFLSLFFFLFFLFFFILFLVFLFLFILFLSLFLFPFVSFPFFFLLFLLFLSFSFCFFFLSFSFCFFSFLFPFVFFSFLSFVSFPFFSFCFFFLSFSFCFFFSFFFLSFFFCFFSFCFFFLSFSFCFFFLSFSFCFFFLSFSFCFFFLSFSFCFFFLSFSFCFFFLLFLFPFFFLLFLFPFFFLSFSFCFFFLLFLFPFVSFSFLSFCFFSFLFLSFSFCFFFLSFSFCFFFLSFSFLFPFVSFSFLFPFLSFLSFSFSFFPFFFLFFLSFLFPFLSFLSFSFCFFFLSFSFCFFFLSFSFCFFFLSFSFCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="7" xmlns="https://uniprot.org/uniprot">
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    <name>A0A812BL10_ACAPH</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_18639</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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            <taxon>Coleoidea</taxon>
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            <taxon>Sepiidae</taxon>
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                <person name="Bekaert M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000671">
        <property type="protein sequence ID" value="CAE1232655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BL10"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1232655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="165" mass="18240" checksum="18088EB03FDB4DBF" modified="2021-09-29" version="1">MCNIGYQPSSDSTECLKVVELYRSCADKNNTRCRGPLAYCDSISKTCHCKDGYIPARDNIRCKKAPKYNLSYAMLGEDCDIDVICQDGNQQVCSLDTSKCTCREGLKPASTIDLNAEPFVFDECRPADFNLGVVITGPWDGLKAANHSLFFSRVTDESTRTNLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BNM3</accession>
    <name>A0A812BNM3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_19368</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000704">
        <property type="protein sequence ID" value="CAE1234456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BNM3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
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            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
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        </location>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        </location>
    </feature>
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        <location>
            <begin position="225"/>
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="403"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="429"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="464"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="497"/>
            <end position="521"/>
        </location>
    </feature>
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        <location>
            <begin position="527"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="553"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1234456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="578" mass="68309" checksum="F5C285B7C4A05DEE" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BP53</accession>
    <name>A0A812BP53_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_19148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000694">
        <property type="protein sequence ID" value="CAE1233918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BP53"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1233918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="216" mass="25394" checksum="532FC93D7D61D559" modified="2021-09-29" version="1">MAVKPSPFFIIKISFLSLLFFLFLASPNGVTKRQTSIGIRDRLLTSSRLFLSFFLSFFLPFFLFSFIIYFFRLFLRSFVKLFSNLFSYFYLFSSFVSLFLSFVFHGSLFLSLMFYFSAIFLFVFILLKFIFLLLFTFVVLFSYSVSFISSLSNFSFPFSFFFSFFLSFIFLIKPVLFPCFCDVAPIPPRLSPSILTLTHTHTSIYLSIYLSIYLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BQ60</accession>
    <name>A0A812BQ60_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_20166</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000739">
        <property type="protein sequence ID" value="CAE1236258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BQ60"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="314"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="345"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="379"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="431"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="469"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="517"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="548"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1236258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="586" mass="69443" checksum="625E6A1F7322925B" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BRW7</accession>
    <name>A0A812BRW7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_25735</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000975">
        <property type="protein sequence ID" value="CAE1247568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BRW7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032570510" evidence="2">
        <location>
            <begin position="25"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="312"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="343"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="371"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="407"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="437"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="463"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="494"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1247568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="602" mass="73733" checksum="BF01171B6498C656" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BS47</accession>
    <name>A0A812BS47_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_21200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Lophotrochozoa</taxon>
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            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000779">
        <property type="protein sequence ID" value="CAE1238196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BS47"/>
    <dbReference type="OrthoDB" id="2384430at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ISR_Activator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45011">
        <property type="entry name" value="DAP3-BINDING CELL DEATH ENHANCER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45011:SF1">
        <property type="entry name" value="DAP3-BINDING CELL DEATH ENHANCER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1238196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="193" mass="21888" checksum="94B2E64B38214DCF" modified="2021-09-29" version="1">MDDSQPLLGAAEQTVRKRNTSEKKKHWTENIPEYARVYLARRKKPDPAYVKIIEALVVIGTILFAIYCYLYFENVHFHAINAYAHLGYSEAQHQVGQRYLHGIGVSAHPEKAMEWFKKASDQGHPHASFNLAVGHLKGIKTPLKTGEAHSLIAEAAQKGMSEAHETLHHNLYINIFLITFGYLSIYLSIYLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BUF1</accession>
    <name>A0A812BUF1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">VARS</fullName>
            <ecNumber evidence="2">6.1.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_23168</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.9" evidence="2"/>
    <dbReference type="EMBL" id="CAHIKZ030000857">
        <property type="protein sequence ID" value="CAE1242059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BUF1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004832">
        <property type="term" value="F:valine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1242059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="150" mass="17293" checksum="85912082B1D483A2" modified="2021-09-29" version="1">MQEQYIFRGLNMAAFGDSLEYLTPEFEAMDMNGDRLLTGREVFELLIYQGVELSENEMLKQLRRLGSSVNLSQFVTFMQNLNNSTRNLRQIFALFTKEDMLSADKTDVLKGLEKMNVKNAAEVVSTMDSNNNQITYKSFLQVYFQGKNDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BUN7</accession>
    <name>A0A812BUN7_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ankyrin repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SPHA_23016</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000851">
        <property type="protein sequence ID" value="CAE1241813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BUN7"/>
    <dbReference type="OrthoDB" id="6054468at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173">
        <property type="entry name" value="ANKYRIN REPEAT CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173:SF74">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="32"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="100"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="133"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="166"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="199"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="232"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAE1241813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="298" mass="32611" checksum="B50D4CF8FC0AE392" modified="2021-09-29" version="1">MGALHYAVISGNVTTVNLLLDYGASVNMLNNSLQSPLHLAITTSQSEISKSLIDHGANVNLRNDAGKTLLQVAVLASNVEITKQILKRSILTIDSKEKLMGRTPLHAACSVNCYPIAKLLINYGANVDFTTKCHTTPLHIASEGGEAKIVKLLIDNSVLVDKTTSTGKTPLMIAIEYGHIKVVDVLMEAKAKVNAKDLQGLTPLHYAAQKNDPYFLKVLIASGANVNAADNKRKTPLHHAIIAKLDDIGDHLIELGADVDVVDDIQMTPMDYKKLRVLRFKVDLLFIKIILKYNYILR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BWZ3</accession>
    <name>A0A812BWZ3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_24349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000907">
        <property type="protein sequence ID" value="CAE1244581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BWZ3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1244581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="152" mass="17370" checksum="F3BADB2E9454660B" modified="2021-09-29" version="1">MRKSFGVFSWAAKAIAVGRPSAAVLGASVHIYLSLFLSIYLSIYLSIYLIENSLPFSLFTFFSMFLLVISFSSLSINFSLCLSFHFLSPNGFYSLFLFYFSTLQPQLFFLSFLLSLSLSFSLASFSYSIYLHPLHQPFSFSTPFFLLVFFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BYJ6</accession>
    <name>A0A812BYJ6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_29232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001159">
        <property type="protein sequence ID" value="CAE1254878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BYJ6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="301"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="402"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="457"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="570"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="597"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1254878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="633" mass="72874" checksum="14637D6827F7F76D" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C1J3</accession>
    <name>A0A812C1J3_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SPHA_27975</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Farmed</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CAHIKZ030001101">
        <property type="protein sequence ID" value="CAE1252387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C1J3"/>
    <dbReference type="OrthoDB" id="5800476at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032880">
        <property type="term" value="P:regulation of protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000703">
        <property type="entry name" value="Casein kinase I gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032514857" description="non-specific serine/threonine protein kinase" evidence="13">
        <location>
            <begin position="21"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="114"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="183"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="216"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="255"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="287"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="323"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="359"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="384"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="411"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="776"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="801"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="844"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="441"/>
            <end position="730"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAE1252387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="865" mass="94076" checksum="E0C161BA3148141A" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C2E5</accession>
    <name>A0A812C2E5_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Synaptogyrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SPHA_27140</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the synaptogyrin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001044">
        <property type="protein sequence ID" value="CAE1250501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C2E5"/>
    <dbReference type="OrthoDB" id="10041611at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031594">
        <property type="term" value="C:neuromuscular junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016579">
        <property type="entry name" value="Synaptogyrin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10838">
        <property type="entry name" value="SYNAPTOGYRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10838:SF20">
        <property type="entry name" value="SYNAPTOGYRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011282">
        <property type="entry name" value="Synaptogyrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51225">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="9">
        <location>
            <begin position="21"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="177"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="183"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR011282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAE1250501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="219" mass="23996" checksum="627B824CB5E72F4B" modified="2021-09-29" version="1">MSSGGAYGAGKAGVSFDPLVFFQRPQVIIRIISWLFAIVVFGCISSGGWFSEQCQFNDDANACRFGSAIGVLAFLGCILFLIIDAIFDNISSVQHRKYAVLGDLGFSGGWTFMWFVCFCYLADSWRKTKQIGPKNHGKDDIQAAIAFSFFSILSFGVLTFLAVQKYRMGASDAFTTGYEPEPNASSPYSSFPGSETGDPYQQPPFSTQKEAPDFQAPTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C3N2</accession>
    <name>A0A812C3N2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LMNA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SPHA_28951</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001146">
        <property type="protein sequence ID" value="CAE1254424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C3N2"/>
    <dbReference type="OrthoDB" id="2441647at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005882">
        <property type="term" value="C:intermediate filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005652">
        <property type="term" value="C:nuclear lamina"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006998">
        <property type="term" value="P:nuclear envelope organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007097">
        <property type="term" value="P:nuclear migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051664">
        <property type="term" value="P:nuclear pore localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090435">
        <property type="term" value="P:protein localization to nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039008">
        <property type="entry name" value="IF_rod_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45721:SF12">
        <property type="entry name" value="INTERMEDIATE FILAMENT PROTEIN IFA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45721">
        <property type="entry name" value="LAMIN DM0-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00038">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64593">
        <property type="entry name" value="Intermediate filament protein, coiled coil region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51842">
        <property type="entry name" value="IF_ROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0403">Intermediate filament</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="IF rod" evidence="5">
        <location>
            <begin position="46"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="36"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAE1254424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="175" mass="20168" checksum="176E60D288728E13" modified="2021-09-29" version="1">MNSSSESFGMDSERIFHRSPLVIAAGLAGNMAYTEADEVRNKRQDEKKLMQNLNDRLAVYISRVRTLETENKALRESLKKKEKVFNSEPLKATYQVEIDETKKRLQATNKENAELKVQVVSIEDQLVKQRSVNLSVCLLIYLSHSVHIYLSIYLSITFCLYLSLYLSQYMSASLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C764</accession>
    <name>A0A812C764_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_28315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001112">
        <property type="protein sequence ID" value="CAE1252965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C764"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1252965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="275" mass="32772" checksum="29D02508CB2C7A2D" modified="2021-09-29" version="1">MCHSVKSSPQSAASATAVHSMSINNSPILTSIYSAATESEFKVLIGQCPFSTVAFICTRLHHNHIRSLNPLYLYNFPLCYRPIITPSPFSFFLLSFLCLSNFPFFYFSFVISVILFFFFFTFSFFCLQSFSFKFSFNFFLNFLLILFQFFHQISFNFFFNFSFNFSFNFSFNFFLQFYFNFSIKFLSIFSSISPSIFPSIFSSIFSFSFISTFPSNFFQFFLQFFLQFFFQFFPLNIFLQFFPSVCNFSLRFSFNFFSQFLPFVIFNFYFSLFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C815</accession>
    <name>A0A812C815_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_30040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001206">
        <property type="protein sequence ID" value="CAE1256223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C815"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1256223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="230" mass="28550" checksum="75DDE33680615716" modified="2021-09-29" version="1">MMKWRQKSFVSRERAISIIFTFSLFRFVFFLFSLSFFLIFPRVSFFLSFFLSFHRFYSFFCSKFLFLFSLSFFSFCFFLFFHILTPPFIFSCCFSFVFILFFSVCLHLFSLLFFSVFFLFFLFSAYGHITFFFFLSFFLSFFLPFHRFYSFFCSKFLFLFSFPFFFFPILFPLPFYFLLFSFSFFLFFSSLRLLSFLSYSFPFFFSFVLSNLFFFLRLFLYFTLDFFSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C8K9</accession>
    <name>A0A812C8K9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_31475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001293">
        <property type="protein sequence ID" value="CAE1258947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C8K9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1258947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="217" mass="27142" checksum="CDB6EB249C46934C" modified="2021-09-29" version="1">MKSKDKTGNKTKENLFFLFFSFFFHFLFSSFLLFLFFFFSFFFFSSFLFFSSFFFLLFFLFFSFSFFFFFFFFFFLFFSSSFFFSSFFLFSLFFSFSLFLFFFFFFSFFLSLLLFSLLLFFSSSFLFFFSSFFLFFFFFFSLFSFFSLFFFFSSFLFFFFFSFLFFFFSLFFFSSFLSSFSLSLFLSLSSLFSFLNLYRFLSISQTSKFITDYSKYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C8V4</accession>
    <name>A0A812C8V4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_30528</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001225">
        <property type="protein sequence ID" value="CAE1256990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C8V4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1256990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="287" mass="33844" checksum="F05664D352BB805D" modified="2021-09-29" version="1">MLSIYLSIYLSIYLSIYVCVVIVFPIHNIYLFIYLSIWVLRAFLLFFFFFFFFSFSTSSSFFFFFFSSFSPPLLLLLLLILLLHLLFLLLLLHLLLLLILLLHLLFLLLLLLFFFSSTSFFFSPSTSFFFFFSTSSSFFFFFFFFSTSSSFFFFFSSSSFFFSSSSSHPPPSSSSSIQFNICLFNIYHFNIYISPLSVSSISIYLSIYLSIYLSIYLSIHIYLFDIYISLFLRFFNIYLLVCLLIFTNIKDGHHHNVISSAQRPSCKSIRMNLSIYLSIYLSIYLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C9V6</accession>
    <name>A0A812C9V6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_33889</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001427">
        <property type="protein sequence ID" value="CAE1263805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C9V6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134:SF22">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134">
        <property type="entry name" value="OS08G0543275 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="290"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1263805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="380" mass="43738" checksum="261662FEFFE9F7D6" modified="2021-09-29" version="1">MTVYLCLLPRPSHTSLLFLSFPFMFTSLLLTHLSIYLFQSVHIYLSLLSIYLSIYFRCAICLFISISVCYLSIYLSIYLFQSVHIYLSLLSIYLSIYLSISVCSYLSQSAIYLSIYLSISVCSYLSQSAIYLSIYLSISVCSYLSQSAIYLSIYLSIYLSISVCSYLSQSIYLSFYLSIYLSIYLSIYLSIYLSQSVHIYLSLYLKIYLSISVCSYLSQSNIYLSIYLSIYLSIYLSIYLSISVCSYLSQSAIYLSIYLSISVCYISISVYIYLSIYLSISVCSYLSQSAIYLSIYLSIYLFQSVHIYLSLLSIYLSIYLFQSVHIYLSLLSIYLSIYLSIYLSISASHEISHFNVTHSFISYLPLPPPPTRFFFPLLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CCM0</accession>
    <name>A0A812CCM0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_33424</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001400">
        <property type="protein sequence ID" value="CAE1262863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CCM0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF5">
        <property type="entry name" value="DYNEIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="308"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="432"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="510"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="553"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="581"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="623"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="658"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="703"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="733"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="769"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="794"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="824"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="851"/>
            <end position="871"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1262863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="889" mass="104118" checksum="5F09EF6532EA42B0" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CDQ4</accession>
    <name>A0A812CDQ4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">PKD1L2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SPHA_33359</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the polycystin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001395">
        <property type="protein sequence ID" value="CAE1262715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CDQ4"/>
    <dbReference type="OrthoDB" id="10050421at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050982">
        <property type="term" value="P:detection of mechanical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.60.20">
        <property type="entry name" value="PLAT/LH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001024">
        <property type="entry name" value="PLAT/LH2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036392">
        <property type="entry name" value="PLAT/LH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051223">
        <property type="entry name" value="Polycystin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046791">
        <property type="entry name" value="Polycystin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10877">
        <property type="entry name" value="POLYCYSTIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10877:SF150">
        <property type="entry name" value="REJ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01477">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20519">
        <property type="entry name" value="Polycystin_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49723">
        <property type="entry name" value="Lipase/lipooxygenase domain (PLAT/LH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50095">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="319"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="355"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="451"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="PLAT" evidence="9">
        <location>
            <begin position="41"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="279"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="279"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAE1262715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="727" mass="83003" checksum="2AEF7283E2CFC46B" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CGN2</accession>
    <name>A0A812CGN2_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TLC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SPHA_34516</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001468">
        <property type="protein sequence ID" value="CAE1265089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CGN2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="369"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="393"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="420"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="7">
        <location>
            <begin position="181"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAE1265089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="437" mass="53092" checksum="0A488E0CF5F4DBED" modified="2021-09-29" version="1">MSDHIYLSIYLSIYLSIYLSEFFLSLSLCLSLFMHTDSTMEMVPHPRASDLYLSLSLSHSLSLSTSVCPYLSIYLSIYLSIYLSIYLCLSQLYINIYLNLFISICLFIYLFIYLFISVHIYLSIYLSIYLSIYLSIYLCPLSIYLSIYLSIYLSMSILSTIYIIFFYFHIFSFFLRTFIFIFYLSFSLCLGTFIFIFLLSFFLLSFLELLFSSFFVLLFAFLSFSFFISFFLSFFLSFFLYSLFVCFFFSSNFLNFYFHLFLSFFFLSKNYFYRFSFMFFFLSYFIRTFIYFILTFIFFILSFFRFFFHSFSVLPRTFIRIFLSLIFISIFFFLSFFLSFFLSFFLSFLALLFSSIFLFFLSFLSFMELLFSSVFLFFFFSFFLSWKFSFHLFLSCLVLLCPSFFFLSQFFLFFFFIEPMFPSFLFFLSFFLSFFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CHK6</accession>
    <name>A0A812CHK6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_35401</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001523">
        <property type="protein sequence ID" value="CAE1266946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CHK6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1266946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="205" mass="23739" checksum="DE60760F88AD8219" modified="2021-09-29" version="1">MVKAILQEFPDNQSLSESAVSIRPQVIARTGYFDQPENLSWFAASVLLLTLLQVIVVLLLYRWLSKKCSKDNETGKEEKVHFSTKKTVVLPEEKKKEKDEVAEISTVKNIISGRPSNFDEKTWETSNISRYDFWNAGKIEGDSYLSLESSSGEMSMPLQSNKRITPLDTEDHNKRFLTESRWEMQKKPKPYSQFTRDRIINAWLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CHM1</accession>
    <name>A0A812CHM1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_34989</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001502">
        <property type="protein sequence ID" value="CAE1266092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CHM1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1266092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="314" mass="36489" checksum="6D395FC3F60EC552" modified="2021-09-29" version="1">MFIRNCFHFLNLIALLNCIFFIIIPVSFFESKAYRNPHLRFSPAVCFFFLTTMRNTTFSVTIREGLHALVTFFYNHRHSLSLSLSFSLSFFNSLLFLFHSLVLPFSLTIAISPLSFTSLFICLFFTCLFSSAPSNSLCLSLCQSVPLFVTFDIAYFFHLFPLPCYVSLFYVIGVDTISLFLFIISFLSVSNHHDISLFSLARSIYLSIYLSIYLSITIRLNIYLILLLSVSLSVSHSFFLAFIHDKKAVVLSFCHNLSPFLLFHQLVFYLIFYLFLFEHNCDRHPLFFYFPLRFLSVSLCPPLTNTYSLYFCIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CIH2</accession>
    <name>A0A812CIH2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_36701</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001613">
        <property type="protein sequence ID" value="CAE1269602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CIH2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1269602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="294" mass="35485" checksum="9EBD560C659CC663" modified="2021-09-29" version="1">MDFRRLAVVPLLFSRKCPLFAQLPINYFFLLNHPIPFFFFFFFFFFFFFFFFFFFYSLFYNLAYCSSTSSFLPLYNHYSFIIFPSPLIFVFNLLNGFVCSSFFLSFFLSFFLSSFLPSFLPYFFISFAFNSCRYESSPLFFLYLRISLFFPLICSLYSTISYFFLIFPYFFSLFCLHYFLSFYSFSPFFCLSFHVLNFTFISFLFNFLLPSSFFFPLPWITLSSFHPLHYISVLLIFFFFCNIFIFLMIFVSPANVLIIFSSSYLYFSPSFLPSLFLPFRLITMDAIVPRSYIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CJ43</accession>
    <name>A0A812CJ43_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ANKS1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SPHA_36966</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001633">
        <property type="protein sequence ID" value="CAE1270232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CJ43"/>
    <dbReference type="OrthoDB" id="5314041at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033635">
        <property type="entry name" value="ANKS1/Caskin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24174">
        <property type="entry name" value="ANKYRIN REPEAT AND STERILE ALPHA MOTIF DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24174:SF1">
        <property type="entry name" value="IP14385P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="161"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="220"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="279"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="320"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="363"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="428"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="463"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="533"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="537"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="555"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAE1270232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="565" mass="65140" checksum="3098A901C03F408D" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CJQ4</accession>
    <name>A0A812CJQ4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_35998</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001558">
        <property type="protein sequence ID" value="CAE1268092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CJQ4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1268092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="229" mass="27086" checksum="3E8BF8388B89F74A" modified="2021-09-29" version="1">MTDVRNGPQIFFLSFILSFFFFFFISLFSFLFICCFYLSLSLSLSLILSLSLSLSLSLTHTFVHIYLRLFISINLSLSLSLSLSLSLSIYQSSYLSIYLSLFISIYLSIYLSIYLSIYIYIYIYIFLFVPTRQFTHRTIHLSIYLSLFIIYLSIYLSIYLCLLSIYLSIYLSLFTSISIKLLKCIYSIFYIPIYFSLFIIYLSIYLSIYLSIYLSIYLYPHAHNTHTYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CLT4</accession>
    <name>A0A812CLT4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_37171</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001651">
        <property type="protein sequence ID" value="CAE1271302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CLT4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1271302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="189" mass="22286" checksum="E49301AD2A45D40F" modified="2021-09-29" version="1">MCHKPFKFFSFVVSQVNGPSAGWGAEVVVDGGSWRICGVRVVDFHCATYSHKDGPFSILFSKGPVHLIHHVFIYFHFSLIFFIAGLTDIFFLSTLHCDFRFLSLSLAFISFLFLFSFSSSFRGLFYDEYLQISDGFLYRQLFIFFYYFFLSFFLSFFLSFFVSFNFFSKMFSFLYIFFLSFFLSFFLCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CR58</accession>
    <name>A0A812CR58_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_41926</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002024">
        <property type="protein sequence ID" value="CAE1279666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CR58"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134:SF22">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134">
        <property type="entry name" value="OS08G0543275 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="301"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="325"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="365"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="387"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1279666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="423" mass="49410" checksum="A107505523E6ADF3" modified="2021-09-29" version="1">MLQIYLCIYLSQSVHIYLSLFISIYLSIYLCSYLSICLTVHIYLSLFISIYLSIYLSIYLSIYLSISVCSCISQSVHIYLSIHLSLFVSICLTVHIYLCLYLSIYLSIYLSHYSSSIYYLSSIYLSSVCSFISQSVYLSIYLCSYLPVSLFISILVCSYLSIYLSIYLSQSVHLYLSLFISIYLSIYLCSYLSVSLFISILVCSYLSIYLSIYLSIYLSLFIYISVCSYLFIYPSIFVIYPVYIYLCSYLQSVHLYLSLFISIYLSIYLCSYLSLFYIYLSLFISIYLSIYLSIYLSQSSVHIYLSIYLSIYLSIYLSQSVHLSIHLSLFISICLTVYIYLSLFISIYLSIYLSIYLSIYLSQSVHLYLSLFISIYLSIYLCSYLSVSLFISILFCSYLSIYLIYLSIYLSQHTYHIYLSIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CS94</accession>
    <name>A0A812CS94_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_41226</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001977">
        <property type="protein sequence ID" value="CAE1278361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CS94"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032832486" evidence="2">
        <location>
            <begin position="20"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="321"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="348"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="385"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="447"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1278361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="503" mass="58474" checksum="C62D7B25268DF4B7" modified="2021-09-29" version="1">MTLLSLISVTSFISSFASSSSSFTCSFTSTFSSNSSFSCTSFISLISVTSFTSFTSCFDSSFLLSSFTSFTNFFTLSTSNSFTFSFTVSSSSSSSSSSSCFTPLSSSFSLLSLISSLLSYSFLFHFFFNFFYFYFIFQFSFIFFFFHFFNFFHLFLYLFIHFFYFYIFFQLLFFFCSYLFIYLFLSISLSISLFIIYLSICLSVCLSQSVYISISLPVSRFVNRFYSSCSLTFPTSFLSLFLNFDLLLLLSLSLSLSLSLSLSLSLFFFTFLFFSLPSSFSLFWITRSSFALIFHISLSIFPPFFSAFFCCLFLSSHMDIFFVFLFPYFPSLFLLLFLHFNFIPLSFFFLSLSFSFSFFHFLILPNSLFSFFFLFSSFFQSCFDLICKSLAFLSFFLSFFLSIFIFPDTLVFPPFPLHFHLSPFFALASISLPTPARFLFLSSSLSLYIYIYIYIYIYLSFQQYIFHQIYSISTSSTKHISTSLILSDDIFLAIVNETHLVWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CSH9</accession>
    <name>A0A812CSH9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">TAPT1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SPHA_40926</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAPT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001946">
        <property type="protein sequence ID" value="CAE1277852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CSH9"/>
    <dbReference type="OrthoDB" id="29023at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045724">
        <property type="term" value="P:positive regulation of cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008010">
        <property type="entry name" value="Tatp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13317">
        <property type="entry name" value="TRANSMEMBRANE ANTERIOR POSTERIOR TRANSFORMATION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13317:SF4">
        <property type="entry name" value="TRANSMEMBRANE ANTERIOR POSTERIOR TRANSFORMATION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05346">
        <property type="entry name" value="DUF747"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032655886" evidence="8">
        <location>
            <begin position="25"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="297"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="486"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="523"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="523"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="549"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAE1277852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="732" mass="80873" checksum="052A0BA3A64F2AB2" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CT88</accession>
    <name>A0A812CT88_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_41712</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002013">
        <property type="protein sequence ID" value="CAE1279212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CT88"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1279212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="206" mass="24249" checksum="4FCB52E16255BAB4" modified="2021-09-29" version="1">MISKEKNVRTRSTLITAELIYLSIYLSIIAYSYVFRIASIYLSIYLSIYLSIYLSIYHCLFKCISDCIYLSNYLSIYHSVFICISDCIYLSIDHSLFKCISDCFYLSIYHSLFKCISDCFYLSIYHSLFKCISDCIYLSIYLSIYLSIYHSLFKCISDCFYLSIYLSIYLSIYLVTIATSSYIYLLHAVHYLSIYLSIYLSIYLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CTJ5</accession>
    <name>A0A812CTJ5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SLC16A12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_41805</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002020">
        <property type="protein sequence ID" value="CAE1279457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CTJ5"/>
    <dbReference type="OrthoDB" id="2213137at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF260">
        <property type="entry name" value="MFS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="320"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="375"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="442"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1279457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="472" mass="51343" checksum="4FF741D3F5E06A32" modified="2021-09-29" version="1">MCLSREFYIHSPALMEQTGPSNIERQTNEVEPETDPDAGDSLHIPDGGWGWAVCFAGFMVNFTIVGLVYSNGIVALGIITIYDSSISKTTMVGSIFIGVVLCAGPFVLLLMMFNVSHRQVIICGGFVSAVATAGSFFVDQVEVLYLTYGILSGIFAGMSYFSSNTIVGSYFKKKRTLAVGISQSGTGIGAFVLNNLLERSISFYGMRGTFLIISGLFLNIVVYGTLCRPLKIVNMKDMNANNLDNSENPGHSANELPTNMIKRFSSKCTYLHKIVFDLDVMKNTGMQLLLTVYFFWSSSEKIYVYLPAKVVNVGLTREQGALIMSIIGAIIGPSQIITGILGDVFHIPISYLLMPSLFGLSATTLAFTFCNSFSLFALCASIFAIFYGVSFTLRMVLVASILGGRNLTKGYSPLCLLVGLTFIIDSKIAGSLFDATQSYDSIFYFTTGSLFIACIVSSGIICLQRNGKFHDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CTR0</accession>
    <name>A0A812CTR0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_41582</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002001">
        <property type="protein sequence ID" value="CAE1278973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CTR0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1278973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="295" mass="34179" checksum="A821C2E10127DE20" modified="2021-09-29" version="1">MLPPKNTCKVCSHLSIYLSIYLALTAPYLSIYLGLFTSMYQSFYLSIYLSIYLSIYLYLIISLSLYLSFSAHLSRAVHIYLSIYLSIYLSIYLSIFTSLSLYLSSSHCSLSIYISRSVHFYVSIILSIYLSIYLSIYLSIYLSIYLCSYLSPCIYLLVLIYLVLFISIYLSIYLSIYLCSHLSPCIYLLVLILYLSRAVHIYLSIYLSIYLSIYLCSHLSPSIYLAFAAPYLSIYLSRSVHFYLSIYLSIYLSIYLSQSLHNSYVYTALHKYTGITLIYMCTIYLSIYLSIYLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CTZ8</accession>
    <name>A0A812CTZ8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_43252</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002160">
        <property type="protein sequence ID" value="CAE1282125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CTZ8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1282125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="282" mass="33094" checksum="A51ABBE14398CF1A" modified="2021-09-29" version="1">MHNGMQLSLQDKLSELTNNLCLSVWAALAQKLVWLITHANLVISLSHIILTLTYSCLYFEKVSIYYLSIFSYLSIYLSIYLSIYLIIYLSIYLSISVCSYFSYLSIYLSIYLSNYLSIYLSSISDFSYLSSIYLYLSIYLSIDFSFISIYLSIYLSIYLSNYLSIPVYIFSVCSIYLSIYLSIYLSIYLSIYLFIYLSIYLRFFISIYLSIYLSIYLSIYLSISDFSYLSIYLSIYLGKADKEKNTFSPIAMNTAFTTCDDELLTRLNLKNTRFYLFFQQKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CYU8</accession>
    <name>A0A812CYU8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">KHDRBS3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SPHA_45834</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002389">
        <property type="protein sequence ID" value="CAE1286167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CYU8"/>
    <dbReference type="OrthoDB" id="6777263at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22384">
        <property type="entry name" value="KH-I_KHDRBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045071">
        <property type="entry name" value="BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055256">
        <property type="entry name" value="KH_1_KHDC4/BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208:SF42">
        <property type="entry name" value="QUAKING RELATED 54B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208">
        <property type="entry name" value="RNA-BINDING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22675">
        <property type="entry name" value="KH-I_KHDC4-BBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="3">
        <location>
            <begin position="72"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="192"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="334"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="208"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="225"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="243"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="297"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAE1286167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="431" mass="47066" checksum="95E721ADEFA314B4" modified="2021-09-29" version="1">MMMAEEDPQQPMQNNTYLDELQGEVSSLAPSSHAARLISEEIERVQSGNAPAGSQKEEKNIPCFEIHTGKPYKHSCKIKIPVKEFPKFNFVGKLLGPKGNSLKRLQEETMTKMSILGKGSMRDKTKEDELRKEGGKYAHLNEDLHVLVEVYAEASDAYQRMAHAFTELQKYLIPNDYNDEIRQQQLQELMYLNGGDGSRGRGRGRGAPGQTPRGAPRGGLLTNPGGRGGPAGRGGAIPPPSRGAPAGRGTPPARGGPPRGGMAAGRGRAAPAPQVPPPMEQSYDDYGYDQSYNEGYGDQGGYEGGYGDQSYGQVDSQYYDYGHGAGGQYDEGYGDGWGTNVGQMKAPPPTRESTQSIPTSSLLQWSSSLSSSSLSHLALQDEFDRLMQTSVSCGPQKTNKRVSEDEEEVSSESWPFMWMLKLQFCIFIVHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CZT8</accession>
    <name>A0A812CZT8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_43372</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002173">
        <property type="protein sequence ID" value="CAE1282307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CZT8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1282307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="176" mass="19911" checksum="9DB784FA595BA123" modified="2021-09-29" version="1">MEFDISSLFVIAVQAHDKNIYLSIYLSIYLSIYHKLIILSLSLSLSFSLSVDHSLSIYLSIYHMLINLSLSLSQSIHISYKLITLSPSLSIYLSIYLSIYLSIYLNFLFISIYLSIYLSISLSSSAHIYLSIYLSIYLSIYLSLSTSIYLSIYLSIAIMSLSDTAIIAECTELSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D0D9</accession>
    <name>A0A812D0D9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">VTA1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SPHA_47839</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VTA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002633">
        <property type="protein sequence ID" value="CAE1289812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D0D9"/>
    <dbReference type="OrthoDB" id="391137at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.420">
        <property type="entry name" value="Immunoglobulin FC, subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.270">
        <property type="entry name" value="Vacuolar protein sorting-associated protein vta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044538">
        <property type="entry name" value="Vta1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039431">
        <property type="entry name" value="Vta1/CALS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023175">
        <property type="entry name" value="Vta1/CALS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041212">
        <property type="entry name" value="Vta1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46009">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VTA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46009:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VTA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04652">
        <property type="entry name" value="Vta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18097">
        <property type="entry name" value="Vta1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vta1/callose synthase N-terminal" evidence="10">
        <location>
            <begin position="15"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Vta1 C-terminal" evidence="11">
        <location>
            <begin position="272"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="159"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="237"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAE1289812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="313" mass="34574" checksum="F5CCA1B40E74A15B" modified="2021-09-29" version="1">MAYSGVGVLPSNLKSIQHYLKTADEHDKRDKVIAYYCRLYALQRAMEIDKKSPDCRTFLMSLMDVQEQMKASLADNDAIQSETVGQAHLENYALKLFLYADNKDRAGEFDKNVVKSFFTAGLLFDALSVFGETDEEIEKNKKYAKWKAAYIHKCLKSGETPIAGPLPEEDENGSMPSINIPPQIGFGGAMQPNFDGLQPSTSYNPNSMNFHPNGPSSQQPDRLQKPPSGSMAPPTTPQDSVHGNNSTTVPAASMYTPWKPPENPAGVHLSTQDYQKAMKFCKFASSALQYEDSKTAIENLQKALTLLTTGQES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D3U9</accession>
    <name>A0A812D3U9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Retrovirus-related Pol polyprotein from transposon 297,Retrovirus-related Pol polyprotein from transposon gypsy</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SPHA_44819</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002296">
        <property type="protein sequence ID" value="CAE1284564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D3U9"/>
    <dbReference type="OrthoDB" id="9908684at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06094">
        <property type="entry name" value="RP_Saci_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.10.10:FF:000007">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000130">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon opus-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053134">
        <property type="entry name" value="RNA-dir_DNA_polymerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034132">
        <property type="entry name" value="RP_Saci-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559:SF454">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559">
        <property type="entry name" value="TRANSPOSON TY3-I GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="453"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="9">
        <location>
            <begin position="211"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAE1284564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="554" mass="61572" checksum="D74F13A4A7E53C3C" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D421</accession>
    <name>A0A812D421_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_47137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002541">
        <property type="protein sequence ID" value="CAE1288491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D421"/>
    <dbReference type="OrthoDB" id="6161790at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1288491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="278" mass="33894" checksum="283DAE89B08D2C13" modified="2021-09-29" version="1">MFSFFLFFLFFLLIFFLSLFHSFLFYSPFFDFSFFLSVVSSLFLSIVVSLYRSFFLSFYPLIFLPFFLSLFLPLFLFSSHRSFFFLSSFFLSFFLSFFLSFYQSIFLSFFVSFYRYFFLYFFFLPIVLFSFFLFIHRSFSLSSYRYFFLYFFFFPSLFLFFFLSFFLSFYQSIFLSYLSIYLLISSYLSIYLSIYLSIYLSIFNIYQLSIYLFVYLSKFVSIYLSIYLSTLVSSDLSIYLNKFLSIYLSIFNIYQSISIEYLSICLSIYLSICVFCSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D6Q5</accession>
    <name>A0A812D6Q5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_48396</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002689">
        <property type="protein sequence ID" value="CAE1290820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D6Q5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="308"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="389"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1290820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="433" mass="51152" checksum="D7373EB688BC84F9" modified="2021-09-29" version="1">MWGVSHPGAGTLSLFLTLASGYSSFHLSFFFSLFFIFPFFFLFASFLFLLLLLSILYPLLHFSLPPLLSIIILQFSLFHPFLHFSFLSLLHFSFLLLSFLLLFAFHSLSMSSSFLSLLLLLSILLPLLSLFHPLLFSIVSLLLHFSSFFHFSSSFFYSSLLLLSSTSFLYCFSSFFLLLLSFFFFFLLFFFTASFIHFFSLLFLFIFPPSSFIFLLLSFILLYCFFHPLLFSIVSLHFSSFFFHFSSSSFFFIFFLYCSFHFSLLLFFYSFFTFFHFFSILSLHFFFFFLLFFFLFFFTLLSSTSFSLLFLFIFPPSSFIFLLLSFILLYCFFHPLLFSIVSLHFSSFFFHFSSSFFYSSLLLFLSFFFFFCLPFIIRFSFFISSSSSFQSFSCFPFSIHFFIFHLFFFSPSSSSFFTSSSCICLFTLSASAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D6T8</accession>
    <name>A0A812D6T8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_48285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002669">
        <property type="protein sequence ID" value="CAE1290585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D6T8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1290585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="213" mass="26190" checksum="57F98E86AECE6F02" modified="2021-09-29" version="1">MNFFLFFLLSFARFFFSSFFFFSSSFLKISFFFIFFVFFSFFRLRSFFLLFVVFSFLLVFLSLFFFRFFFFSFRLSFIFFVVFLLFRRLSSFSSSFSFFLLFRRLSLSFFFFVVFLFLSFFSTFRSVFLSYLSSSFFLFSSFSYFLLSYLFSIFFLSHLSSDFLLLSTFVLSFFFNTFFSSPRSCLPYFRNLNFILFFRSFQHLSFLSFSLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D766</accession>
    <name>A0A812D766_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_48021</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002655">
        <property type="protein sequence ID" value="CAE1290370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D766"/>
    <dbReference type="OrthoDB" id="266138at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
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        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0472">Membrane</keyword>
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        <location>
            <begin position="39"/>
            <end position="56"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        <location>
            <begin position="105"/>
            <end position="125"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="159"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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        <location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="716"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="866"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="915"/>
            <end position="935"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1290370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="945" mass="109989" checksum="E39FB708C8C0D92E" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D8I1</accession>
    <name>A0A812D8I1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_49427</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
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    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002825">
        <property type="protein sequence ID" value="CAE1292727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A812D8I1"/>
    <dbReference type="Proteomes" id="UP000597762">
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            <end position="298"/>
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    </feature>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
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        <source>
            <dbReference type="EMBL" id="CAE1292727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="316" mass="38599" checksum="0579835F1D9D5002" modified="2021-09-29" version="1">MFNFFLSFLPSFLPSFLLSFFLSFFLSFFLLHVFFSPPFSSFFLSLYISFFLSFSLFQVSSFSFLFHYFFLSFCSKLLIRSFFISFFLSFSLFQVSSFSFLFHYFFLSFCSKLLIRSFFLSFFLFFLFVSSFFFFFSISLFFSLPSSVVSCLFVLSLFFLSFFSFFQTFLFYFIFFFFPFKFLIRFFLSFFSFFLSYFFYFFFLFFKCLKLLISFFFLSFLSFLSFFFLFTCFFFLFFFYFFCFFLSLLSSFLFLSSMYLSSSISFFLFSFCSMLLMRLFVFLSFFLSFFSFFLSFFLSPQVFYLSPSCCQSSSEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D9E7</accession>
    <name>A0A812D9E7_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heme-copper oxidase subunit III family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_51805</name>
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    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
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        <lineage>
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            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
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            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003164">
        <property type="protein sequence ID" value="CAE1297052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D9E7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Cyt_c_oxidase-like_su3"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
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    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1297052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="346" mass="41886" checksum="8FADF2E48F7BA56C" modified="2021-09-29" version="1">MYSFCLSFHSFSSFFPSFYIHSFLFLFILSLFLFFLTLFLLSLFLFILSFFSSFFSFSFHSFSLTFLLSPFLFILSVFSFFLAFFSFFPSFLSFFFFFILSRFHSFHSFSLSLNSFRLFFLSFFSFFLSFFSFFLSFLSFFLFILYFFLFILSLFLFILSVFSFFLFILSFRLFILSIFSFFLSFFLSFHSLFLSFHSFSLSLHSFRLFFRFSFFSFFLSLFSFFLSFSSFFPSFLSVFFLFILSVFSFFLAFFFFLSFFSFLLLFILSLFLSNLSVLFPFLTPLILLFSPLFSFPSFHFISYTYIFPYHFIHLYSLSESFRPLNSLFIFPIPCSLIVSFIFFLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D9F0</accession>
    <name>A0A812D9F0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SelD</fullName>
            <ecNumber evidence="8">2.7.9.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SPHA_51087</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.9.3" evidence="8"/>
    <dbReference type="EMBL" id="CAHIKZ030003065">
        <property type="protein sequence ID" value="CAE1295746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D9F0"/>
    <dbReference type="OrthoDB" id="409395at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004756">
        <property type="term" value="F:selenide, water dikinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016260">
        <property type="term" value="P:selenocysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02195">
        <property type="entry name" value="SelD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.10:FF:000006">
        <property type="entry name" value="Selenide water dikinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.650.10:FF:000010">
        <property type="entry name" value="Selenide, water dikinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="entry name" value="PurM-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="entry name" value="PurM-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004536">
        <property type="entry name" value="SPS/SelD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00476">
        <property type="entry name" value="selD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10256:SF0">
        <property type="entry name" value="INACTIVE SELENIDE, WATER DIKINASE-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10256">
        <property type="entry name" value="SELENIDE, WATER DIKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="PurM C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="PurM N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0711">Selenium</keyword>
    <keyword evidence="1 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PurM-like N-terminal" evidence="6">
        <location>
            <begin position="186"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="PurM-like C-terminal" evidence="7">
        <location>
            <begin position="307"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAE1295746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="496" mass="53026" checksum="96B57B9CD9C5B3F5" modified="2021-09-29" version="1">MDDLIEYIFYTELVTEILSPSLCLSPSLCLSPSLCLSPSLCLSPSLCLSPSLCLSPSLCLSPSLCLSPSLCLSPSLCLSPSLCLSPSLCLSPSLCLSPSLCLSLLSVCLLLSVCLLLSVCLLLSVCLPSSVSSVCLPSLSLSVLSLSVSFSLCLSSLCLSLLCLSLCLSPSLCLSPSLCIGMDSSVTPLRHGGLSLVQTTDFFYPLVDDPYMMGKIACANVLSDLYAMGVTECDNMLMLLGVSNKMTDKERDVVVPIMMRGFKDLAEDAGTQVSGGQTVVNPWLTIGGVATTVCQSNEFIMPDNAVVGDVLVLTKPLGTQVAVNAHQWLDQPERMSRLKMVVSEDDIRKAYHRAMCSMSRLNRTAARLMHKYNAHGATDVTGFGLIGHAKNLAKIQKNEVSFVIHNLPIIAKMAAVSKACGNMFGLLQGQSAETSGGLLIALPREQAAAYCKDIEKQEGNQAWIIGIVEKGNRSARIIDKPRTIEVPAKEKEGELW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DAS6</accession>
    <name>A0A812DAS6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_52895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003326">
        <property type="protein sequence ID" value="CAE1298888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DAS6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1298888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="307" mass="37366" checksum="2F6A7E61F9FE8AA7" modified="2021-09-29" version="1">MIQKYTRIHIYLNFCSDYSYLSICSYLSIYLSIHICLLVYSYLSIYLSIYSYLLFISIYLSIYSYLSISLFISIYLSIYSYLFISIYLSIHICLLVYSYLSIYLFQLYIFFVLSFSFATLSFFCSFLLICYSFFLLFFPSHCHYFFLNDTLHFFFFSFLSFFLFFSICHFFSFSFFLSFFLSFFLSQLTHFPSFSLSFFLSFFFFCFPSFLFLFLFFFLSFFLSFSISAFISFFLNCHSFFFFSSFLFSFFFLSKNSFFSQLPIFLFFLSFFFQLMLFLSFFLSFFLSFFLSFFLSFTNAICNFLQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DCT1</accession>
    <name>A0A812DCT1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_51716</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003153">
        <property type="protein sequence ID" value="CAE1296922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DCT1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032695220" evidence="2">
        <location>
            <begin position="20"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="407"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1296922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="439" mass="48464" checksum="B9507B51AE47C796" modified="2021-09-29" version="1">MTFTHFLYHFRFLILLLQSLYSPFFPYHRAKTYAARLASSDRAKTYAARLASSDRAKTYAARLASSDRAKTYAARLASSDRAKTYATRLASSDRAKTYAARLASSDRAKTYAARLASSNRAKTYAARLASSDRAKNYGARLASSKRPRPTQQDWPAQIGPRPTHQDWPAQIGLRPTQQDWPAQIGLRPTQQDWPAQIGLRPTQQDWPAQIGLRPTQQDWPAQIGAKTHAARLASSDRAKTNAARLASSDRAKTYAARLASSDRAKTYAARLASSDRAKTYATRLASSDRAKSYAARLASSDRAKTYAARLASSNRAKTYAARLASSDRAKTYGARLASSDRAKTYAARLSSSNRAKTYAARLASSNRAKTYATRLASSNRAKTYAARLASSDRAKTLEQDWPAQIGLRPTQQDLPAQTGLRPTEQDWPAQIGLRPTQQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DCV0</accession>
    <name>A0A812DCV0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_51375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003108">
        <property type="protein sequence ID" value="CAE1296272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DCV0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="273"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="301"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="331"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="416"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="443"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="476"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1296272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="507" mass="56981" checksum="EFF31F3CB31A3C5D" modified="2021-09-29" version="1">MKTRSIVLAFHLSISFSFICVWCSFLSYTPFVHVLFLFSSTYLPFFLSHPSLSFQSSPSLFVFSIFFIPLCLFNLLHPSLSFQSSPSLFVFSIFSIPLCLFQSSPSLFVFSIFSIPLCLFQSSPSLFVFFFNLLHPSLSFQSPPSLRLFNLLHLSVFSISSISPSFQSPPSLFVFSIFSIPLCLFNLLHPSLSFQSSPSLFVFSIFSIPLCLFNLLHLSVFSISSISPSFQSPPSLRLFNLLHLSVFFSISSISPSFSISSIPLCLFQSPPSLFVFSIFSIPLCLFNLLHPSLSFQSSPSLFVFSIFSIPLCLFNLLHPSLSFQSPPSLRLFNLLHLSVFSISSIPLCLFNLLHPSLSFQSPPSLRLFNLLHLSVFSISSISPSFQSPPSLCLFMPPLSFISLISLSFLFPHLSVVSISSISISLIFPISLSFFMSSITFSSLFILLHLSFLVTYSLSLTLLFISFSLSLHSFSSLFLLFAFSFLLFCLCFFLLSLHLFLYFLCFQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DD26</accession>
    <name>A0A812DD26_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Tafazzin family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SPHA_50597</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Farmed</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine = a cardiolipin + a 1-acyl-sn-glycero-3-phosphocholine</text>
            <dbReference type="Rhea" id="RHEA:33731"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="ChEBI" id="CHEBI:62237"/>
            <dbReference type="ChEBI" id="CHEBI:64743"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:33732"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:33733"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine</text>
            <dbReference type="Rhea" id="RHEA:43816"/>
            <dbReference type="ChEBI" id="CHEBI:28610"/>
            <dbReference type="ChEBI" id="CHEBI:72998"/>
            <dbReference type="ChEBI" id="CHEBI:73001"/>
            <dbReference type="ChEBI" id="CHEBI:74669"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:43817"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:43818"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion outer membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the taffazin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002998">
        <property type="protein sequence ID" value="CAE1294855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DD26"/>
    <dbReference type="OrthoDB" id="193467at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047184">
        <property type="term" value="F:1-acylglycerophosphocholine O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035965">
        <property type="term" value="P:cardiolipin acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007007">
        <property type="term" value="P:inner mitochondrial membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07989">
        <property type="entry name" value="LPLAT_AGPAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000872">
        <property type="entry name" value="Tafazzin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12497:SF0">
        <property type="entry name" value="TAFAZZIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12497">
        <property type="entry name" value="TAZ PROTEIN TAFAZZIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00979">
        <property type="entry name" value="TAFAZZIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="14">
        <location>
            <begin position="65"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAE1294855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="264" mass="30641" checksum="54CDA86D72758E7E" modified="2021-09-29" version="1">MPIDHIWIFPPANKPSKIWNISTKIILSLVGASSKLWSDWLNTFNLINGDILYKTIEDRPSNQGLVTVSNHYSCIDEPLLWGILKWKYLIGARNIRWTLGADNICFTKYWHTVFFSLGRVVPVCRGEGVYQRSMDFVLEQLNRGQWLHMFPEGKVNLTKECLRLKWGVGRLIADCNNNSLVLPMWHIGMDSILPNKKPYIPRIGQTVTILVGEPLQFKSDVDSLRQDGKSAREIRKHITDKIQEEMKLLRKRAEQYHCEKLHKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DEC6</accession>
    <name>A0A812DEC6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ARHGAP20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_50838</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003021">
        <property type="protein sequence ID" value="CAE1295217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DEC6"/>
    <dbReference type="OrthoDB" id="9994905at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23179:SF27">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN AT 71E, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23179">
        <property type="entry name" value="T-CELL ACTIVATION RHO GTPASE ACTIVATING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="1">
        <location>
            <begin position="29"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1295217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="268" mass="29908" checksum="5EEE7D3BC6A735DC" modified="2021-09-29" version="1">MSMLRNVFGGCVSDKSTENVKNQKLKFGVPLSVALKHGYLPHPFVELLVYIAKEGVATTDLFRRPGNPNDTRRIVKRLQEGKPVVFANYNFYTLASVVKKFILKLPGGIFTPEGEEYLLEVLTMTRRFEQCQRVNEFIKSLSVGHQQLVSLLFGTWFRIVNHSDVNSMSVEALARSVAGILESSSKFEEIFYSYPSVSPSLSFTSLPLLYHYPLHPSIIYVPTSPPTFISLHTSPNPSTLPHPPLFTSPLLTPPHSACVVGGKQLLKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DG81</accession>
    <name>A0A812DG81_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Sodium/hydrogen exchanger</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SPHA_51228</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003089">
        <property type="protein sequence ID" value="CAE1296068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DG81"/>
    <dbReference type="OrthoDB" id="196264at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015386">
        <property type="term" value="F:potassium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004709">
        <property type="entry name" value="NaH_exchanger"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00840">
        <property type="entry name" value="b_cpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="SODIUM/HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110:SF191">
        <property type="entry name" value="SODIUM_HYDROGEN EXCHANGER 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01084">
        <property type="entry name" value="NAHEXCHNGR"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0050">Antiport</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10 11" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="234"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="264"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="310"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="353"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="399"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="427"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="464"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="491"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="13">
        <location>
            <begin position="122"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAE1296068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="625" mass="69958" checksum="FC2E2D81F1BAB0AB" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DIF3</accession>
    <name>A0A812DIF3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_52906</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="2373" mass="272429" checksum="B0E03EECCBCF221D" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DK32</accession>
    <name>A0A812DK32_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">LHX3_4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SPHA_57448</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003877">
        <property type="protein sequence ID" value="CAE1304957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DK32"/>
    <dbReference type="OrthoDB" id="10068367at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000120">
        <property type="entry name" value="Insulin gene enhancer protein ISL-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050453">
        <property type="entry name" value="LIM_Homeobox_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208">
        <property type="entry name" value="LIM/HOMEOBOX PROTEIN LHX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208:SF128">
        <property type="entry name" value="LIM3, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 9" id="KW-0440">LIM domain</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 9" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="132"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="165"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="229"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="337"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="11">
        <location>
            <begin position="46"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAE1304957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="377" mass="46205" checksum="C583D6A622A3A9DB" modified="2021-09-29" version="1">MKSSRFEQFFHKEAVWGRVQRILWMKQFIYLSIYLSIYLSIYLSIPKCAGCSEQILDRFILKVLDRSWHSKCLKCTDCHAQLTDKCFSKNDEVFCKDDFFRVPPSSFFCLILILFYLFYSFFVFLYSHFPLLLFFFFSLFFFFFFFFFFLFFFFFFFLSFFLSFFLYLFIYFSLYSFISVLLSFCLSFYLSLSLFPQNFYFLLSFRFIFFFFRHLFFRHLFFRHLFFRHLFFALFSSAIFSSAIFSSAIFSFAIFSSTIFSLTIFSSAIFSSFLFSFAIFSSAIFFFHHLFFRHLFIRQHFFRHLFFRHLFLYFFFLFLLYFPSIYSFFLYYPFLQLLLILLSCLLPSICSNSIICFLSRSTSVSNIPARMRGYSYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DMG4</accession>
    <name>A0A812DMG4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_57002</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003813">
        <property type="protein sequence ID" value="CAE1304408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DMG4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1304408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="289" mass="33460" checksum="0F60912C11D62270" modified="2021-09-29" version="1">MQFLSFPLKNGQVRLVTSFFIIRLIQMYEIVSLLVNVYFSLQQRLALNLFRYTKAYINKPLYFFLFSLSFLHHFFSLYQFSFGLASLLSSFLFCISISFFLTLFVYLPLSLSLSVCISLYISFPLPASLSVCTSLSFFLSDCLSFYVSLLSSIYQLVSFSCLCFFSLPTCLSVSHFLFFNVPISLSVSLFLSVFLLLSICHSFSVSLFLSLSLSMLVCCFLFICLSLILSVCGFQVPGQTIFKYFLLWAEIYLSIYLSIYLSIYLSIFKQNHHVWLEHIYSSLHRYDNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DPA1</accession>
    <name>A0A812DPA1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_57659</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003892">
        <property type="protein sequence ID" value="CAE1305183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DPA1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1305183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="200" mass="23166" checksum="6E7776FCC02FF8D4" modified="2021-09-29" version="1">MTFSVKSRYSRSFILSPVNTSNLPHISVSFSCSFPNGHFPLFAFCYCLFHDVHYFLLLSVSSRSILFLCSLLPGNKKYLSFLKKYLSLFPPSSLSSFSSLACFRHLSIYLSYSLFLSIYLSIYLSIYLSILFSLSIYLSICLSYSLYLSILFYLSIYLSIYLSNSLYLSYSIYLSIYLILFIYLILSIYLSIYLSIYLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DT82</accession>
    <name>A0A812DT82_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_62135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004414">
        <property type="protein sequence ID" value="CAE1310604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DT82"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1310604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="245" mass="28982" checksum="1DA7BFBBE731AA1E" modified="2021-09-29" version="1">MHIYLSIYLSIYLFQSIHIYLSIYLSIYLSYLSIYLNSWLDIYVSIFALYSICSHFIYLSIYLSIYLSIYLSLLSIYLSIYLSIYLSIYVQMFSLPIPIYLSIYLSIYLSIWQCFHIYLYLILIMYNSANLFISLSLSLSLSLSIYLSIYLSILGSSSYSSIYLSIYLSIYLSIWQCFNIYLYLILNMYNSANLFISLLLSISIYLSIYLSIYLFQAIHIYLSIYLSIYLSIYQFLSFFSSSFPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DU57</accession>
    <name>A0A812DU57_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_62242</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004433">
        <property type="protein sequence ID" value="CAE1310699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DU57"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1310699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="273" mass="31280" checksum="7A472932B77C79D1" modified="2021-09-29" version="1">MCVYLSIYLSIYLSIYLSIYLSIYLSICQSQSVAIYQSIAIYLSIYLSIYLSIYIYIYIYIFIIYVSIYLSICCQSIYLNVLLSIYLSLLLSISLLTSVYSYLSIYLSIYLSIYLSISICCYLSVDLSQSVVIYLSQSVAIYQSICLSLLLDTSLFTSDYCYLSIYLSIYLSIYLLLSEMANITITVYLSIYLSIYLSIYLSPSVAICQSISICCYLIICLLLSIRLFISVCCYLSIYLSIYLSIYLSIYLSISVCSLSIYLSIYLSIYLSID</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DV75</accession>
    <name>A0A812DV75_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_61452</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004347">
        <property type="protein sequence ID" value="CAE1309768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DV75"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1309768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="252" mass="27724" checksum="AAA36794284D726F" modified="2021-09-29" version="1">MHGGRPHSSPAPMINAQLIPDRHSFTTATVLVSLNPWARAAPLHSITVLVFFFFPKVRLNPYFPRMFRWGPTYLPQPLKVSTKAFTFLSPSNTLQVKSGPSFSKRYTCAFLLPVCSLPSPPLSRQPRRGSRGPPGWGRAQMTLFSRTSNPFLPSIRVKVVPFGVVHLSLARTGSSQVTRSSTPPTNSLLITCRKVPDHTTCPASQSFMLPISLLKPIDISGTPTSPRSSVASDPATLILTSCQLRLSYEKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DXT3</accession>
    <name>A0A812DXT3_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transmembrane 9 superfamily member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SPHA_64142</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004620">
        <property type="protein sequence ID" value="CAE1313006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DXT3"/>
    <dbReference type="OrthoDB" id="1666796at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072657">
        <property type="term" value="P:protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004240">
        <property type="entry name" value="EMP70"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766:SF55">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02990">
        <property type="entry name" value="EMP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="71"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="260"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAE1313006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="340" mass="39188" checksum="64FC7A7D07D5E8EA" modified="2021-09-29" version="1">MSDVQIHWFSIINSVVVVFFLSGILTMIMVRSLRRDIARYNKDEDIEETLEETGWKLVHGDVFRPPRHPKLLASLIGAGNQIFCMSLIIIFFAMLGMLSPASRGALMTAAIFLFVFLGLIAGYFSARLYKTMKGNQWKKAAFQTATLYPGILFGTCFILNFFIWGKHSSGAVPFSTMVALLCMWFGISLPLVFLGYFFGFRKQPYQHPVRTNQIPRQVPEQMWYMNPILGTLMAGILPFGAVFIELFFIFTAIWENQFYYLFGLSLVVALLYSIWRLCSLYVCLFHLLFCYKAGDHRVHSNSPLFWLHTADVIHFLDPDWHHWILCGILFHSTDLCSYQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DZW0</accession>
    <name>A0A812DZW0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_65477</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004724">
        <property type="protein sequence ID" value="CAE1314539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DZW0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1314539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="235" mass="28926" checksum="CA9D48BE899D0E7D" modified="2021-09-29" version="1">MFISLFSILFLVVYCLFSFQTLRVLLHYYYLRPSPFVFLSFFFLSFIFLSFYLALFLFSFFFFLTDFRFFCRSFFFLSFFFLSIFLYFLSFLFSFFRNHVVSFSFFFLLFFPSFFLTFVISFFFFCLSSFRSFIFLSFFRLSFFLSFFLSFFLTFLSFFVSFFYLSFFLSNFLSFLLPFSFLSFFLPFSFFFSVFLPSFFFLNVVVSFYFSFFLPKFLSFFNDLSFLSCNLILCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E1J5</accession>
    <name>A0A812E1J5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_62991</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004513">
        <property type="protein sequence ID" value="CAE1311613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E1J5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1311613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="370" mass="43605" checksum="37F3469AF8F71410" modified="2021-09-29" version="1">MSDTGYCMQLGTLRYTFFSSPLSLSLSLFLSLSLFIHFHPIIIKLSTFFSPSFLFDVSFFYLLSFLGGSLFLFFFAALADSPSPSMISFFFFPAPFHRLDAESGGGWKARTRFERVINNIVLNSNPRLSPFNPLSLSLSLSLSLSLSLSLWAFFSVYFVCFFLSLSFFLSFFLSFIFLFLFLSFFLFSFFFSFFLICPRRFFLPSRRFFSFLSFFLSFFLSFFLSFFLSFFLSLFLSFFLSFFLSFYLHPFYFLFNYFFIILFCDICFFSSSSYYVFTLSSAIFLTVPISRVNGRGPLAIHARANRPTDRPAQLHVTSRRTMTQKPCFLFRNYQLFVHNKPNAYFLLLFQMMECFLPSVRRQQRDRSFLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E1L7</accession>
    <name>A0A812E1L7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_63025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004519">
        <property type="protein sequence ID" value="CAE1311658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E1L7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="284"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1311658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="331" mass="37870" checksum="BAE985A6F9103B8E" modified="2021-09-29" version="1">MLLNSISLSLIIILAFFLSLFISLYLSPYLSLSPSFLCLQYIFHIFLYSISFSLIIIFSLFLFLSLPLSLSLSLSLSLSLYLSLISMCILFVYPLSSLLPSLSFSIALFFSSRKPLSAQKLPAILSKYLTRFLFVSSSKHLFSAIHFFCSMSFLIYHCPFTVFHSHIVLISAIEFHLRSFHHFSVFRSYLLFISSSMLLFLSFFLPLSLSLSFSLSSSFAMFRFYSYFYLFSLTLPLSHSLSLFLTSSFSFIFFYSIYLSLIFLSLFLFTNFRHLLTPSAFPSTFFASFSLSLFSLSLSLSSLSLSLSLSIYLSWRYSVDDCLLSFAFSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E6B8</accession>
    <name>A0A812E6B8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_65488</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004724">
        <property type="protein sequence ID" value="CAE1314525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E6B8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="352"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="390"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="419"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="446"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1314525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="499" mass="59356" checksum="7738236F8C1B0A11" modified="2021-09-29" version="1">MAISVCWHHCSRVVPINTTAGPLIFSPKPHSTRTDRPESVHIYLSIYISIYHGLFISIYLSIYRSIDRSVYLSIYLRLFISIYLSIYLSIYLSIYLSQSVHIYLSIYLSIYLSICLSIYLSETVHIYLSIYLSIYLSIYHHHSLFISITVCSYLSIYLSISLSLSLYIYIYIYIYIYIYIYIRVCSYLSIYLSIYLSITVYSYLFIYLSIYLLIDRSICLSIYLSETVHIYLSIYLSIYLSITVCSYLFIYLSIDRSVYLSFYLSETVHIYLSIYLSIYLSIYLSIYLSQSVHIYLSIYLSIYLSITVCSYLSIYLSIYLSIYLSIIFSLNSSSFFLSFFLSFFSLTFTGSFFLSIAFIFISFFLSFFLSFFLSFFLSIAFIFISFFPSFFLSSFLPFFLSFFLSFFLSFFLFPDIYQFFLSFYCLYFHIVLSFFLSFFPLPLFSYLSFFLSFFLSFAVIFVSFFFVSLFLSFPVSIWFSQHHDICHRRRHSYKCKRCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E9R2</accession>
    <name>A0A812E9R2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_71077</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005202">
        <property type="protein sequence ID" value="CAE1320918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E9R2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1320918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="275" mass="32638" checksum="43EBF0D39FAB65B4" modified="2021-09-29" version="1">MIPFTHSPSQSNRSFVPHPSSNNQSSTLLHLIRAFFLSFFLSFFLSFFLSFFAPIVFLCRFFYFFLRSFFFSFILSLFHAFPFSFSIFSISFFFFFLSNSFSFVVSFSITFSVSPFLFLSRLLSFFLSFFLSFFLSFFLSFFLSCLFAFFAVFLLLSFFLSFFLSLSYLFLAAFSFSSLFSFTFFSVPFFSFFSFLHFLSFLKIILFFVENNFLMAPVMCRTLTLAQSGKKWMINNNNIPKQGFYTEQGWDRHICVVFSCLCFYVWVKKREKSED</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EC80</accession>
    <name>A0A812EC80_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_71746</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005255">
        <property type="protein sequence ID" value="CAE1321641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EC80"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1321641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="257" mass="29391" checksum="AAB9CB8A3F3A80E6" modified="2021-09-29" version="1">MSQCLKFPKPSNIRSHKLSSFRCPLRLKFPKSIRHPFLCYLKQSPKPSDIRSRPNSPNHPTSVHKPSSFCFRCPSALNSQTIRHPFTSYLPFAFDMSCAPLNFKPSDIRSHKLSSLLSDVLCALNSPTIRHPFTLSYLLLLDVPALNSPKPSDIRSHKLLPCFQRPVRLKFPKLSDIRSHSSYLPLLFDVLCALNSQTIRHPFTQAIFLCFRCPVRLKFPNHPTSVHTSYLPFCFRCPSALNSPNHPDIRSHKLSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EDY1</accession>
    <name>A0A812EDY1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_73490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005380">
        <property type="protein sequence ID" value="CAE1323572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EDY1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1323572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="197" mass="22542" checksum="E1A3288E8981B8AE" modified="2021-09-29" version="1">MMAYLCSINSSDRSSQWIDIIIIIIIIRVAISFSLFLSGTHFGRRHYSHCHDDDNDVRTNNSDDYVQIYLTLFIFLFLSLCLSSLSLSVCLTLLISIYLSIYLSIYLSQSIHIYLSIVDSYLQSIYLSIYLSIYACSSIYLSQPASFYLSRQLAISTCSHLSIYLSIYLSIYLCICVCIHISEDVYYIVVCACIHVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EF75</accession>
    <name>A0A812EF75_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_70130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005126">
        <property type="protein sequence ID" value="CAE1319822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EF75"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1319822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="159" mass="18892" checksum="B55FFBB22737678D" modified="2021-09-29" version="1">MNVFLVIFNFSYLYLYCCFYLSITIWFDSNTFVTINLSIYLSICLSIYLSQVIIYLSVYYIHIYLIVNLQAYFSQFILSISPSIYLMCGYLSIYVCSLFIYLSITIHFDPTMIIKKILFLLLFIDHILFLFYCQFFPSLCFSTNKTNMSRFLLIDLPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EHV3</accession>
    <name>A0A812EHV3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_72788</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005344">
        <property type="protein sequence ID" value="CAE1322899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EHV3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1322899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="215" mass="25615" checksum="71E43F610737F9F1" modified="2021-09-29" version="1">MRHHSYLSIYLSIYLSIYLSISICSKISIYLYIYLFKDIYLCLSVQRYLSIYMHLFKDFFLSIYLSIYLSIYVYLFKDIYLSIYLSQSVQIYLYVCSNVFFYLSLISLSLSFSLSIYISISVCSNLSIYLSIYLSKYIHIIYQILFTSTPFCSHLSHSIHIYLSISVSSYLSIPLYSHLSIYLSIYLSIYLIVPILYHYIFPFYLRYISLSLYLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EIY6</accession>
    <name>A0A812EIY6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_75304</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005455">
        <property type="protein sequence ID" value="CAE1325709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EIY6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1325709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="257" mass="30991" checksum="4F1DCD22FF5D3F35" modified="2021-09-29" version="1">MPSDGGTHKTTVSLSITLLSFFLSFFHSFFLSFLSFFLFFLSFSNTDYLSFFFPFFLSFVLSFFFPFFLSFVLSFFFPFFLSFVLSCFFNVFLSFFLLSFSFSFVLILFILYRFFFFLSFFLFFLFFFFSFCLLSFFLFFFFPPFFPPFFLSFFLFFFLSFFFSVLSFLRSFSFFLFCLSVFLSQIQIFFLFFSSFSLTCFFLFLSVFSPFFVFSIFLSSFLSFFLLFFLSFFLSFFLSFFSNSPSHFPAAVKTLLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EQF1</accession>
    <name>A0A812EQF1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SPHA_78575</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005544">
        <property type="protein sequence ID" value="CAE1328950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5813223at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050372">
        <property type="entry name" value="Neurexin-related_CASP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036:SF49">
        <property type="entry name" value="AXOTACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036">
        <property type="entry name" value="PIKACHURIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1238"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="6">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="6">
        <location>
            <begin position="78"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="263"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="6">
        <location>
            <begin position="513"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="684"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="6">
        <location>
            <begin position="728"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="915"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="6">
        <location>
            <begin position="957"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1148"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1198"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1378"/>
            <end position="1479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1150"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1198"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1402"/>
            <end position="1436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1457"/>
            <end position="1476"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="290"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="887"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="923"/>
            <end position="940"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAE1328950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1506" mass="169821" checksum="2F06FF5BC7FF82FD" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ET63</accession>
    <name>A0A812ET63_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_79434</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005567">
        <property type="protein sequence ID" value="CAE1330087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ET63"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1330087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="331" mass="39779" checksum="0462080A5164FFEB" modified="2021-09-29" version="1">MEPDHLKNQWNVYLHSFHHPQHQTLLFISVIQTVRRQIAAGFDYLHLFFYFTFHFGSFLLIFIHIFQYFLFFSFLFYLRLSFMLLSYLSIYLSIHLSIYLSIYLSIYLSYSVSISCFYPSIHLSIYLSIYLSIYLSIYLYSVSISCFYLSIYLSIYLSIYRILLLSPVSIYLSLYLSILPRLFISLHLFVIKYFYTSIFLSMYVFIFRSFFRPLLPLFLSVVLAYFSLIILFCLFVDTKNYSGTSFIHAFLHYLFISFVLGFFSFCLFCDHYKLFVFFISFFLLFVNNIIFYLTAIHFFYFSINDYLSSIILLFFSPKPFSFLSFFPFLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ETK9</accession>
    <name>A0A812ETK9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_80142</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005591">
        <property type="protein sequence ID" value="CAE1330848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ETK9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032319406" evidence="2">
        <location>
            <begin position="30"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1330848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="382" mass="44980" checksum="7BFB01F6D66BC9F5" modified="2021-09-29" version="1">MSDALNSPSFSFTFLCDWLFALTRRPVSAAITRAHDGQREASVAIYMCNTQPGSLIMHPFTSFHFLYSFLIYPSFLFWIFLLLSFLHLSNFLREFAIYHLSIYLSIYLSIYVVYTQIYLSIYLSIYLSIYLSMFISKYTQIYLSIYLSIYLSIYLNLFLLSYPPLPPVFSSYFSPAIFLLYLLLLLSSIPPPPLLLLLLLLLLLPIIPPLYFFFVLHLFILLFFYYIYIHFLHHLHFFFFFFFFFFFFFFFFFFFYLLFFLLVPSPLLLLTPPFPRHLLPPPLPSSSSSSSSSSTSFLLLRHPPLHHTLLPPIHSLPPSSLLLLLLLPFPPLPSCPFPSSSSSPSFTSEFSSFTLFFFFFFFFFFFFHFEFPPPLHFPSSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EUF4</accession>
    <name>A0A812EUF4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_80115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005591">
        <property type="protein sequence ID" value="CAE1330846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EUF4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1330846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="173" mass="20968" checksum="5BDD86F915CD4916" modified="2021-09-29" version="1">MRSSGLFQRPLSFQMSVSLFLTAIHLFSSLCLFIRFLFVCLFVCLFVSFFLSFFLSFFLSFFLHPLLTFMVFFLFYASLISFVNFFLFFFVCLFLSFFLSFFLQLSFFFLSFFFFYIPYLYGFLPLFLLLSFFLSFFLSFFLSSCILFLFFWHSFFLSFFLSFFLSVFLSCTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EXI4</accession>
    <name>A0A812EXI4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_81213</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005627">
        <property type="protein sequence ID" value="CAE1332136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EXI4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1332136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="227" mass="26604" checksum="10C2404F3AC3CF20" modified="2021-09-29" version="1">MILSREGNESVHIALSLSLSLSLSLSLSCPANYPILFLSSLFISFLFICLFVSFFLSHSFYFFPLSFILSFFHSFFLSFFLSFILSFIYLSIYLSIYLSIDLILFSFFRLSLYVFFFISISFFFLSFFPSFFLSFKFSFFFSLFRSFYLISFLSFFLSFAFSFFLSIYLSIYQSIYLSHSLFFLLSFLISVFPSFCLSLFLSVFLSILHVPVVNSLLFNFALSYSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EY32</accession>
    <name>A0A812EY32_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_79791</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005577">
        <property type="protein sequence ID" value="CAE1330485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EY32"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="180"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1330485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="225" mass="25628" checksum="3C574ADBD4026312" modified="2021-09-29" version="1">MNSDMSLHDLINYARTTETIASHLQTMRLEDNNTATATIAPINKVADEQRQPSNYPRQYQCRNCNGKYPHERGPTSCPAFHTQCTHCGMWGHFTSVCFRRLNDGNRQRKTNRPPRTQTNRRSVNHIENDQWNPHSSGSDTEYVFHTAGAQNLPPPIEMDTPANRSSSLFLGLTNQIKGQLDEQSETLHKINSTVQKLEAENALYKQELMTAHTNIHQLSSLLDNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AMJ6</accession>
    <name>A0A812AMJ6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_1680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000047">
        <property type="protein sequence ID" value="CAE1145729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AMJ6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1145729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="171" mass="20205" checksum="4B925994C0800E06" modified="2021-09-29" version="1">MLFLSIYLSIYLSIYLSIYLSIISIYLSIYLSISASHYFVSIYLSIYLSIYLSISMSNHYISISLYVYLSIFVYLSISLCLIIYLSIYLSIYLSIYLCLIIIYLSIYLSMPNHYLCLIIIYLSNYLSMCNHYLSICFFAYLSIYLSIYLSIYFCSPIYLSIYLSIYLFIYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ARV7</accession>
    <name>A0A812ARV7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_3470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000105">
        <property type="protein sequence ID" value="CAE1152600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ARV7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="322"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1152600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="403" mass="47668" checksum="377D7E91E578488C" modified="2021-09-29" version="1">MIYFLIYLSIYLSIYLNILIIICLSFFLSIFLSFYLSLYISIRSLSMYLSIYLSIYLFIFFLSIYLLFILLSISFCILSIYVCSLSIYLSIYIYIYIYVCMYVYMYVCMFMCVCVCVCVCVCVCSLSIYLNSFIYLSISLYLSIYLSIYLSISIHYYLSIYLSIYLSISFCSLSIYLYIYIYIYIYIYIYIYVCVCIHVCMYVHVCVCVCVCVCVHYSSISIRSSIYLSQSVHYYLSIYLSIYLSIYLSISIRSLSIYLSIYLSIYLNPFIIYLSIYLSIYLSIYLFISHIYPFIYLSIYLSIYLSINPFIIYLSIYLSQSVHYLSIYLSIYLSIYLSQSVDYLSIYLSIYLSISIRSLSIYLSIYLSLSLSIYLSIYLSIYLSIYISIYLSTSVPLYIHIVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ATQ4</accession>
    <name>A0A812ATQ4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_6698</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000219">
        <property type="protein sequence ID" value="CAE1161085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ATQ4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1161085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="280" mass="31844" checksum="8210978301DA03AD" modified="2021-09-29" version="1">MSRASSPPPPPPPTTHLVFCATLSPLFCLRLPFAPTLPPAAHPHPAPLNAVPSVPPFLPSILPPTSPHCHLPTQPLFLSCSHFDTLFLGPSNIHVLSFTWDSLFFFFASRSLSLSFPDAADVFFMEDLYLFQSIYLSIYLSIYLSIYLSIYLSQSVHIYLSIYLSIYLSIYLSIYLSLFLSIHPSIYLYVLVRSSYFVIHLSIYLSIYVSIYLSIYQSVSLPIYLSIYLSIYLSVCQSAYLSIYLSIYLSIYLSVCLSIYLSIYLSIYLSIYLSICLFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AZL1</accession>
    <name>A0A812AZL1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_8134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000263">
        <property type="protein sequence ID" value="CAE1164709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AZL1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1164709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="378" mass="41398" checksum="6CE4EC1788F7EA9C" modified="2021-09-29" version="1">MCRPPETDDFFFIMFICAHHFDSLQLFSSRLLSPHVSLSLSLSLSLSVSLSLSLSLSPYVFPPFQSNHIRILTFLPTLGSTVFFFGLPFILIVCSFESILTTFHEITTLQPTLLHCLPAILSDFFYPSSFGPKTINVRFDEETNGSVIGRKNDLSFFHLSLSLSLSLSLSTSLSFNLSLSTSLSLSLSTSLSLSFNLSLSSSLFQPLFPPLSPFPPLSSFPLLSFLPHLSFPLSFTPLSLPTFLVRPLSFNLSLSTSLSLPTSLFLPTSPFHPLSFHLSLSPPLSFNLSLSPSLSSHLSLSTCLFPSLSLPTSPFQPVFFHLSLFPPLPFNLSLSTSLSSHLSLSTFFPSLSFPTSLFSTSLFPPLSLSSHLSLSTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B0E9</accession>
    <name>A0A812B0E9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_8006</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000259">
        <property type="protein sequence ID" value="CAE1164427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B0E9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1164427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="212" mass="25148" checksum="6EBA987155213DB4" modified="2021-09-29" version="1">MHIRESILRLVTGPSSAADIKNTNLPVLRRVSPVASRSPLYHILFLSFFLPFHSLFSLFSYHLSIFLSFFLFLLSSLSIIFSFFSFFLSSFSFFIFPILISSFYLSFFLSFLLSSLSIIFSFFLSFFLFILYFPYSHIIFLSFFLSFFFFYLASLSYSLSFFLSFFLFILYFPYSHIIFLSFFLSFFFFYLASLSYSLSFFLSFFLSFFLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B269</accession>
    <name>A0A812B269_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_8526</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000277">
        <property type="protein sequence ID" value="CAE1165617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B269"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1165617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="414" mass="45878" checksum="5650EA9A26BEB162" modified="2021-09-29" version="1">MKRNNLSISRQLGLASTVCSNHFVDGCPTIMNPLPTLNIEPPPKDKEDKKKSASRLYKSIIERNLFNKTQEKYREQPQQQQQQQQQEIVKLSETVKSSLQRSSNKVLEQLQCVEESRNEKLFKAMLYQMTPQTQNKPQQKINVSAALGKPANIERSRKSPLNIASTSNSTVESKTIEVENASPPPKKVREIHIDIDVSEEESPVVSKPLLQPTIEPPAQKSVTTSMKSTPAQPSSVVHNPVLDINVPQKQKRILVVPNHQQSVMSNLSSLWKAGRLCDAFISNGTVNVKVHKMILGAVCPKVLDVFYSTPQHKLPKVTFPNSHLPLIPLCGHGQLLPPPFLVSPLCLLLFSGCRLLIQLPWSLFCACHSSVGASSFSTFLGLSSVPVILQWAWAASPPSFVSHLCLSPLPPSKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B2U8</accession>
    <name>A0A812B2U8_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SPHA_9854</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Farmed</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="2"/>
    <dbReference type="EMBL" id="CAHIKZ030000313">
        <property type="protein sequence ID" value="CAE1168055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B2U8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46077">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TOPORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46077:SF1">
        <property type="entry name" value="TOP1 BINDING ARGININE_SERINE RICH PROTEIN, E3 UBIQUITIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="307"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="335"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="373"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="15"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAE1168055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="423" mass="48425" checksum="736EE58202E54CF1" modified="2021-09-29" version="1">MVLANRLRCIRKNRSNNTSSSSENQNSGRSNNTSSSSESQNSRGSNNTSSSSESQNSRGSNNTSSSSESQNSRGCNNTTSSSESQNSRGSNNTSSSSESQNSRGSNNTSSSNCQSSNRKKSSSKTSDPCRWRSALILSFFLSFFLSLSDFLLLLFSLFFFFLSFFLSFFAFLLLLFSLLFFLPFFLSFFSFLSFFSFFLFFFFLCLLFSCSCSPSCSPSSFFLSFFLSFFLSFFLSLLFSCSCSPSSSFAFLSFFLSFFLSFFLSLLFSCSCSPSSSFAFLSFFLSFFLSFFLSFFLSFFLSSAFLLLLFSLFFLFLSFFLSFFLSFFLSFFLSFFAFLLLLFSLFFLSFFLSFFFSFFLCRLFSCSCSPSSSFAFLSFFLSFFLSFFLSFFLSYLMQHNGLYFLSPPLNTNLHYLIRQKNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B4K2</accession>
    <name>A0A812B4K2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RTN4IP1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SPHA_11285</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000372">
        <property type="protein sequence ID" value="CAE1170884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B4K2"/>
    <dbReference type="OrthoDB" id="48317at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08248">
        <property type="entry name" value="RTN4I1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000147">
        <property type="entry name" value="Reticulon-4-interacting protein 1 homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037397">
        <property type="entry name" value="RTN4IP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050700">
        <property type="entry name" value="YIM1/Zinc_Alcohol_DH_Fams"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695:SF294">
        <property type="entry name" value="RETICULON-4-INTERACTING PROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="6">
        <location>
            <begin position="10"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAE1170884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="355" mass="38846" checksum="B0B2BD3C15E7EB61" modified="2021-09-29" version="1">MSAWQIYSYKDDLTLSKTMRIPSIDDPGDVLVEVHASSVNPIDVMMKDGYGEKLINMIRWQLGVKHFAGSEFPLTLGRDFSGVVTAVGKEVTRFKVGDEVWGATGGFRQGCHADFCLASVKEVSHKPNNLSHVEAASLPYVALTTWSALCLVGEIRQKNAQSHRVFIQGGSGGVGTFAIQLMKAWGAHVTTSCSTDAVPLVESLGADVVIDYKTQNLKDELKNTEGFDVFLNTMEAEDCMDSLKKWSNAKYVTIKTPFLKDIDDHGFPAGAVLSASKLGCNLLHGLKDGRNYRWAFFIPNPRALNTVKELVEAGKIKPVIEKVVPFEEAPAAYNHVGETHNRGKTVLNMKPAGET</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B689</accession>
    <name>A0A812B689_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_11814</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000393">
        <property type="protein sequence ID" value="CAE1171899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B689"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1171899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="192" mass="21707" checksum="1CB15BA29F44A4D4" modified="2021-09-29" version="1">MDSSSNHEQQQQSSTGAAIMNSSSNHEQEQQTWTAAFFFPLVLSIYLSIYLSIYLSIDFFAKSISLVISSPLSLSLSLSLSLSIYLSIYLFQIVHYLSIYLSIYLSIYSMLFIIYLSIYLSIYLSIPDFTDTVSLCSPRSIRHFSFSSIAPRDTHLAVFANFLLSSFRLSLPMPLLFSGNVSILLFLDTHVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B848</accession>
    <name>A0A812B848_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_11945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000400">
        <property type="protein sequence ID" value="CAE1172200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B848"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="361"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="391"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="430"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="544"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="655"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="688"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="722"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="750"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="777"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="811"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="940"/>
            <end position="962"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1172200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="968" mass="116287" checksum="E48103EA2E41B34A" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BBC1</accession>
    <name>A0A812BBC1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_13544</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000457">
        <property type="protein sequence ID" value="CAE1175288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BBC1"/>
    <dbReference type="OrthoDB" id="9635126at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF4">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="416"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="827"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="869"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="875"/>
            <end position="906"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1175288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="935" mass="104827" checksum="EF798BB78C7A3CC4" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BCD0</accession>
    <name>A0A812BCD0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_14208</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000485">
        <property type="protein sequence ID" value="CAE1176606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BCD0"/>
    <dbReference type="OrthoDB" id="10068441at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45913">
        <property type="entry name" value="EPM2A-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45913:SF11">
        <property type="entry name" value="EPM2A-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1176606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="225" mass="25767" checksum="39AF60496B8DD81F" modified="2021-09-29" version="1">MFFPMFRNIHLSVHKCLEFNTVLESFSIYLSIYLSIYLSIYLSIYLIMLIYLSIYLSIYLSIYLSISLSAYIRLCSYFLLTPKPKCQSGSNKSYLSCCRSISFKTVLRRKTCILKSAEIVCSEKRQILTYFFLTRNTVAETISDLSADLDRQLKHKVKSIIAFSVAINESMNITEVAQLAIFHRCADEILTTNNIFHLSRCSAGQSRGGLEPVLSVWGLQMALHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BGY7</accession>
    <name>A0A812BGY7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_16510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000581">
        <property type="protein sequence ID" value="CAE1227728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BGY7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="324"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="382"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="425"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="475"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1227728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="495" mass="56520" checksum="3FC1D5EE96EE389E" modified="2021-09-29" version="1">MIVLSSVDIMLSIFIFLFPFLQFLALLLLLPFFLLPRLLPILLFLVFLFVVVLFIFFFHLLCFYLSLFLFYFLFFFYFFCFFCFFFFFFSFLFLYFFFCFFFCFFFFFFSFLFFYFFFYIFSTSSSFFNFFSFYFFFFFSSISSSSSSSSSSSSSSSLYSSICSPPPPPLSSISSPSSFSSLSSSLSSSSSSSSSSSSFIFSPPPPPSSSISSPSSSISISFSTSLATSPSISSFLLFFLVFLLLLLLLLSLLLLLIPFLPLLLLLSIFSSSPTSFSSSPSTYFSSSSSSSSSSSSSPSSSSSSFSSSFSPSSYHGTHTLTHSFSIVSLSLLFTLSFSLSLSLSLLIGIQIHNFHIFHFGGTQVDAYFIISLSIYLSIYLSIYLDLFIIYLSIYLSIYLSIYLSDMSRQEIYLNETHHLLVSQSIYLVCSCAFIWVYSCLSVHLTTHFVHIYLYIYLSIYLSQSFHYLSEFVHYLSIYLSIYLSIYLSIYLSIYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BH03</accession>
    <name>A0A812BH03_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_17400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000620">
        <property type="protein sequence ID" value="CAE1229657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BH03"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1229657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="198" mass="23414" checksum="CF7A7C1E4EC9EB8C" modified="2021-09-29" version="1">MYRPSVNLHLFLFKDFFFFFFTFFSLSHSPTFFFYLFLIFRSSIIFLLFLSSLSLSLSFGCVFIISFKCLLSFLTLPFPFFSLFSIFTSSITYFIISFFFFLSLSLSLSLSLFFLFFIFGHRRYILLFISFLFILTLSFSSFSFLSFFPDTLSSFSFLSFFSGTLSSFSFISFFPHSLLSFFFPNSLLSFSFLSFFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BH87</accession>
    <name>A0A812BH87_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_15578</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000543">
        <property type="protein sequence ID" value="CAE1224965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BH87"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1224965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="167" mass="18864" checksum="D0E50199D176C47A" modified="2021-09-29" version="1">MAFSFKWPLSLTFPLNGLSLSLSQISFKWPLSTFPLNGLSLFSFPLNGLSLSLSLTFSFKWPLSLSHISFKWPLSLSFTFPLNGLLSLSFPLNGLSLSLFKLAFPLNGFSLSLFPLNGLSLSRFFKWLLFLSHFLNGLSLSHISFKWPLSLSHISFKWPLSLSLHFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BID4</accession>
    <name>A0A812BID4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_17174</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000610">
        <property type="protein sequence ID" value="CAE1229220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BID4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1229220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="196" mass="22659" checksum="8F5EF5E1776A7811" modified="2021-09-29" version="1">MHSLTSHCSVTFFFVIAIFVYLTYLPLPFFQLVFHFLGLFPLISLFSLLSLSLSLSLSLSLSRSLAVTNHLAAFLSPHFSFFLFLSFLRLFSAGKEREIEKKTDKTNAEKKRRNMKHSLKSLSLSLIYLSIYLSIYLSIYLSIYLSQKRLRSIYLSNSFCSFSFFLSFFLSIYLSIYLSIYLSIYLSTAAPLNLRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BID6</accession>
    <name>A0A812BID6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_17250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000613">
        <property type="protein sequence ID" value="CAE1229346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BID6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1229346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="242" mass="27841" checksum="62DBF5E6F4A1AE83" modified="2021-09-29" version="1">MSPQPHHGFLRFLTPPHIFLYMYPASCLSASLTHPSCLFLSCISLSLHPPASSLSLSLHFTPCQDFAPTPCLCAHLRRLCAPPPRRVFAHPLLLSVSLSLHHVYFLFYSFISYTLPSACFSISFSLFIFKHIVFFFFVFAVIRLFSDFSSSCLFSSTFSYLEWIFFLFLRILPFVFKIVNFFASLSTPFSFLMLHFPPTAIFFPACISFSDSLHVLNVLYCRRLSFSFCYMISSFLILIKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BK36</accession>
    <name>A0A812BK36_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_19113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000691">
        <property type="protein sequence ID" value="CAE1233787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BK36"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1233787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="167" mass="19699" checksum="95352ADA762C9AAE" modified="2021-09-29" version="1">MISLACLLRGDKEETFFKLYFNIVFSFHFKCPSPFNSNFVVLTFTRPSSSSTSFFFFFFFFFFFFFFFFFYLSPFLFSFSSFLLVPFFFLLPLFLLLPSSFSSPPLFLFLLLLSPSLLLDMNNIYLSIYLSIYLSIYLSIYLSIYLSIYLFVHNLSISVLGCSYLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BNP1</accession>
    <name>A0A812BNP1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">EVX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SPHA_20724</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the even-skipped homeobox family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000761">
        <property type="protein sequence ID" value="CAE1237368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BNP1"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052002">
        <property type="entry name" value="Even-skipped_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46294">
        <property type="entry name" value="SEGMENTATION PROTEIN EVEN-SKIPPED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46294:SF4">
        <property type="entry name" value="SEGMENTATION PROTEIN EVEN-SKIPPED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 7 8" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="10">
        <location>
            <begin position="51"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="7">
        <location>
            <begin position="53"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAE1237368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="285" mass="30886" checksum="F7357965E0E3D800" modified="2021-09-29" version="1">MTDVPLSSSSSSPSSPLSPGRVISPSEHSAVNIDHYPTVSAKYKELKVDDIQARRYRTAFTKEQISRLEKEFSRENYLSRPKRCELAADLQLPESTIKVWFQNRRMKDKRQRMAVTWPFGVPDPNMFAFFAAMSSYPYSLPTAHAQLGYHALGLPRVPTPTLANPIQPRADLLHTIPSPLTRSLSLEAAAAAAAAAAAPPPSHSVPPLHSGLSCGLSFQSHAYASQLMGAQNLGLCPGSTPGKPCNCPHSLSERLHHGLINPSFGLSNILNNSSSHSVASIQNQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BQM9</accession>
    <name>A0A812BQM9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="13">KRAB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SPHA_19900</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000724">
        <property type="protein sequence ID" value="CAE1235665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BQM9"/>
    <dbReference type="OrthoDB" id="8918594at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990837">
        <property type="term" value="F:sequence-specific double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000322">
        <property type="entry name" value="GDNF-inducible zinc finger protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000325">
        <property type="entry name" value="ZFP90 zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000690">
        <property type="entry name" value="Zinc finger protein 354C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000303">
        <property type="entry name" value="Zinc finger protein 41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF48">
        <property type="entry name" value="ZINC FINGER PROTEIN 771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033020275" evidence="11">
        <location>
            <begin position="21"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="40"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="68"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="96"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="150"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAE1235665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="258" mass="29241" checksum="EF6BF59C3693D3AF" modified="2021-09-29" version="1">MRCKLFVVVQSLAVSAPVLSFASTLKNRNLPDWSASEKPYKCDHCDRRFMQQSHLVGHLRSHTGDRPYKCGFCQRGFFTASHLTQHSKIHTCEKSFKCDVCSQFFSQYETLAEHMQIHSKPRPFKCDFCEKGFTSSSNLTKHKRIHTKPCKCPVCNKGFVRNSEVARHMRTHTNENASEPMPPAIGTAFTLENDFLQSYNQVENTHLVPEMSDLDIPGDTAAAATVTNSDNGKCLPLDHMQHLDLSRTLIPLSYHLVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BR44</accession>
    <name>A0A812BR44_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_20641</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000758">
        <property type="protein sequence ID" value="CAE1237214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BR44"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1237214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="178" mass="21217" checksum="0A5F3738938D06D9" modified="2021-09-29" version="1">MLSRGILFSIYLSIYLSIYLSIYLSIYLSCSVHISLSFYTLSIYLSIYLSIYLSIYLSIYLSMLFCTHFAFILYISIALHFSYFFLFSHLLMFFVYHFLISLNIKPLPFSFLLYTTAVQNVCLASFFLSFFLSFFLSFIPYFYIILLPLNIKAFFFFHIYVIFSICSYSFFLSFFLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BRI6</accession>
    <name>A0A812BRI6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_22261</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000822">
        <property type="protein sequence ID" value="CAE1240324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BRI6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34723:SF7">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34723">
        <property type="entry name" value="PROTEIN CBG17025"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1240324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="255" mass="28970" checksum="CCFC6E11A5A95561" modified="2021-09-29" version="1">MFFFLFIFIFFDLSFFFSSFPSFFPSCLHSFLPSFIPSFLSSILSSLLHSFIPPIFRSFVPSIHPSFLPSIYLSFLPSFLPSFLPSFSFFLSSFLLSIHPLILPSFLPSFLSSCFSSFLPSFLLSIHPVILPSFLSSFLPSIHPFNLSFFLSFFLSFFLSSILPSIHPSFLSSFHLASLPSFLPSILLSIHPFILLSFLLSFLPYFVPSFFSSCLSSFLPFIHSPFLPSFLPSFLPSFLPSFLPSLCLFSRQLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BSI8</accession>
    <name>A0A812BSI8_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AF4/FMR2 family member lilli</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Protein lilliputian</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SPHA_26049</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Farmed</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Has a role in transcriptional regulation. Acts in parallel with the Ras/MAPK and the PI3K/PKB pathways in the control of cell identity and cellular growth. Essential for regulation of the cytoskeleton and cell growth but not for cell proliferation or growth rate. Required specifically for the microtubule-based basal transport of lipid droplets. Plays a partially redundant function downstream of Raf in cell fate specification in the developing eye. Pair-rule protein that regulates embryonic cellularization, gastrulation and segmentation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AF4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000995">
        <property type="protein sequence ID" value="CAE1248204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6382204at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032783">
        <property type="term" value="C:super elongation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007366">
        <property type="term" value="P:periodic partitioning by pair rule gene"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2670">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007797">
        <property type="entry name" value="AF4/FMR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043640">
        <property type="entry name" value="AF4/FMR2_CHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10528">
        <property type="entry name" value="AF4/FMR2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10528:SF17">
        <property type="entry name" value="AF4_FMR2 FAMILY MEMBER LILLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18876">
        <property type="entry name" value="AFF4_CHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0562">Pair-rule protein</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
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            <begin position="1540"/>
            <end position="1700"/>
        </location>
    </feature>
    <feature type="domain" description="AF4/FMR2 C-terminal homology" evidence="14">
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            <end position="1839"/>
        </location>
    </feature>
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    <feature type="region of interest" description="Disordered" evidence="13">
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    <feature type="region of interest" description="Disordered" evidence="13">
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF18876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAE1248204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1841" mass="198660" checksum="96D0CCB03DA0D92B" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C0X0</accession>
    <name>A0A812C0X0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_25758</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000976">
        <property type="protein sequence ID" value="CAE1247635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C0X0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1247635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="156" mass="18147" checksum="6B48B09E3F46B8F1" modified="2021-09-29" version="1">MFKFFYSFVSTHQYLSIYLSIYLSIYLSMRTYTYLFLCVCFIMKKGGLNGFFSLTLFLVLFLSPPFSLYLFICLSIYLSICLSIYIYLSLSTVFFARAQRFSHFVFLPLSLSLSLSFSLSSPLLSLLSPFMSVYVRARRHLKVVVILSDLFICEIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C249</accession>
    <name>A0A812C249_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_26882</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001028">
        <property type="protein sequence ID" value="CAE1250005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C249"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="297"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="366"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="443"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="478"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="508"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="566"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="610"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="636"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="745"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="770"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="795"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="822"/>
            <end position="841"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1250005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="842" mass="98694" checksum="E05A0EF6A3A35205" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C2H1</accession>
    <name>A0A812C2H1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GABRG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_30081</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001209">
        <property type="protein sequence ID" value="CAE1256312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C2H1"/>
    <dbReference type="OrthoDB" id="8890589at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="274"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="2">
        <location>
            <begin position="236"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1256312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="307" mass="36566" checksum="30D039322F79FE0D" modified="2021-09-29" version="1">MYLCLSIYLSIYLSIYLSILLIRFFHQFFSSKSSLHLFSFLFITAFFLLLFTFQTDCLFKFPALGDGRKKSTKILARLFFHLYLYTHIRILFVSSALSLYLYSFCIPNVNPSFFLSFFIYLSIFFLSFFLSFFLCFSFFLSQFFHSFYLRCFFFFLSFCLFLSLFFFFSFFLPFFVSLFLILFVLSFFLCFFSFSSFVLSFVFLALWLTFAHVFLSFLFSFFISFFLSVLSFSAETYLPCYLIVSLSWISFWINRDAAPARVLLVYLTNTFKAVLPFFSFFLFLLLLLLLLLLLLLLLLLLHPTSCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C2K4</accession>
    <name>A0A812C2K4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_28687</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001125">
        <property type="protein sequence ID" value="CAE1253940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C2K4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1253940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="154" mass="17635" checksum="1DFBC6F1358DB040" modified="2021-09-29" version="1">MLQRRLHVQLYSFKAVEDSFQQQMVMLQRRLHVPAFSFKVVDSFQQPNGNTSDDFMSQLYSFKAVKIPFSNQIIMLQETTSCPSFIPFKAVEDSFQQPNNNASETTSCPSRSFSFLQDTYVPDSFQQPNNNASETTSCPSFILQGCRRFLSATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C5S6</accession>
    <name>A0A812C5S6_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cytochrome c biogenesis B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_28883</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001140">
        <property type="protein sequence ID" value="CAE1254317.1"/>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001177">
        <property type="protein sequence ID" value="CAE1255385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C6X7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="305"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="341"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1255385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="360" mass="41997" checksum="65E97655D66AB1AF" modified="2021-09-29" version="1">MSPQRSVQRVCISSLIYKHVYLSPFDIYLSIYLSIYLSQHHVYVCIYLSPPDIYLSIYLSQHVYPTFSVSYLSIYLSPPDFYLSQPLYLSPPDIYLSIYLSLFIYLSIYLSPPDIYLSIYLSLFIFLSIYLSIYLRLISIYLSISAYLSIYLSIYLSISACFSIYPGPILSIYLSIYLSISNFSLSVSVHKSIYLSFHITLLFISIYLSIYLSIYLSIYLSHSTSYLSIYLSIYLSQSTSLSIYLISPHIYLSIWAPRRGLRLENNYLSIYLSPLHIYLSIYLSQSTSLSIYLSQPTSYLSISVHFIYIYLSIHLSIYLSISVQFIYIYLSIYLSIYLSPLHIYLSISVHFISIYLRIYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C6Y5</accession>
    <name>A0A812C6Y5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RUBCN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SPHA_30688</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Late endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001236">
        <property type="protein sequence ID" value="CAE1257261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C6Y5"/>
    <dbReference type="OrthoDB" id="10067503at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901981">
        <property type="term" value="F:phosphatidylinositol phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17686">
        <property type="entry name" value="RUN_RUBCN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052428">
        <property type="entry name" value="Autophagy_HostDef_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025258">
        <property type="entry name" value="RH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048569">
        <property type="entry name" value="RUBC_PIKBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004012">
        <property type="entry name" value="Run_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037213">
        <property type="entry name" value="Run_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45971">
        <property type="entry name" value="PHOX (PX) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45971:SF1">
        <property type="entry name" value="RUBICON, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13901">
        <property type="entry name" value="RH_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21054">
        <property type="entry name" value="RUBC_PIKBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02759">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01175">
        <property type="entry name" value="DUF4206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00593">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140741">
        <property type="entry name" value="RUN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50826">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0072">Autophagy</keyword>
    <keyword evidence="3" id="KW-0967">Endosome</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RUN" evidence="6">
        <location>
            <begin position="41"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="200"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="349"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="542"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="208"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="309"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="355"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="563"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAE1257261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="994" mass="112133" checksum="2832CC4145519716" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C794</accession>
    <name>A0A812C794_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_29642</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001183">
        <property type="protein sequence ID" value="CAE1255513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C794"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1255513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="301" mass="35293" checksum="3154120C9A3B16CF" modified="2021-09-29" version="1">MTLLFIFFLSIYLSIYLSIYLSIYLSIYHSLFIIYLSIYLSIYLSIYLSIYLSLFISIYLSIYLSIYLSIYLSQSVPYLSIYLSQSVHIYLSIYLSIYLSQSVHYLSIYLSIYHNEASRLYLFSSFEERHFKGVRQGGIYHFFQVLSSYIFGIFYQYIILNDIFLFSLFSLSLTLSLSLSFSLQFSHSLSNSLSLQLSIYLSIYLAIFLHLRHFLSIYNFKRYFFYFPSSLSLSLSPILSLSIYLSIYLSIYIFSIFYQYIILNDVPFLNFPSSLSFTLSHSLSNSLSLSLSLSLSSYLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C8X4</accession>
    <name>A0A812C8X4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RUS1 family protein C16orf58,RUS1 family protein homolog,RUS1 family protein C16orf58 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SPHA_32305</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RUS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001339">
        <property type="protein sequence ID" value="CAE1260625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C8X4"/>
    <dbReference type="OrthoDB" id="364779at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006968">
        <property type="entry name" value="RUS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055412">
        <property type="entry name" value="UVB_sens_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054549">
        <property type="entry name" value="UVB_sens_RUS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12770:SF31">
        <property type="entry name" value="RUS FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12770">
        <property type="entry name" value="RUS1 FAMILY PROTEIN C16ORF58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24160">
        <property type="entry name" value="UVB_sens_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04884">
        <property type="entry name" value="UVB_sens_prot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Protein root UVB sensitive/RUS" evidence="7">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Root UVB sensitive protein C-terminal" evidence="8">
        <location>
            <begin position="163"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAE1260625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="280" mass="30818" checksum="24B17F027C5A551F" modified="2021-09-29" version="1">MLGRIIFAWMQGTNLDCNAKRCRFMADILNDFAIFLEIVAPIIPGFFTLIICIAGLCKSIVGVAGGSTRAALSQHQARKNNMADVAVKDGSQETLVNVTALLFSLAMTPLITGNQPLILFLFAAFTFLHLISNYMAVTSVVMETLNQARLSILVKEFLKSTQALSVQEANYQEPVIFKTSMKMSIHLGTSLKNACSDEEDFNTLKKIYGSSKFLTSADLNEDHIHILLCTGCTVDDELQACFQAEVINAAMDCNIPEKNLEKTSLLQKLVQAARESEYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C961</accession>
    <name>A0A812C961_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_34993</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001502">
        <property type="protein sequence ID" value="CAE1266038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C961"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1266038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="196" mass="23488" checksum="96E9D7E4F862D740" modified="2021-09-29" version="1">MDYFISFVFHKSFLHGHILFTYLLIIYSPFIFHSFFSLSLSFFFHFLSFFLSFFSFFFLSFFLSFFSFSNSLIISFFLDFLIITFSLFIIQIHFFFFVICLSIASLPMSSLFTSNRLSFFYFPHFPRNHIFLTFFLNNSLVSAFAFPRQTSVFGNNNVRNYLQTLLTTVLNLSIYLSIYLSIYLSIYLYSRRILLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CAI8</accession>
    <name>A0A812CAI8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_31318</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001282">
        <property type="protein sequence ID" value="CAE1258620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CAI8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1258620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="192" mass="24514" checksum="1116225F313EE88F" modified="2021-09-29" version="1">MHFFKLFLLYFFCSFIFLSLIFLFHFILYFASSFFLFILHFLLLFHLFFIFNIFFFHFYSSFSYFFYFFFIFFNFFILHFISFVYFLHFYFTFSFAVYSSFSLFYFFFILLLLFIHLIYFTFSFSLLHFHFTPFALFIFLISTSLIFRFSYLFIQFFLSFHSIFFPFLFYFFISLFLCYFFISLFFLHFFFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CBR3</accession>
    <name>A0A812CBR3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_32198</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001335">
        <property type="protein sequence ID" value="CAE1260378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CBR3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1260378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="210" mass="24328" checksum="58D6FD6C0C326CA0" modified="2021-09-29" version="1">MLFVSRNVASDIVVPFSFLSLTLYFSMQDATFLLSKLNFFLSFFLSFFLSVMCLCQLFLSCSPTHNRDRIERERKRERERERERERELSLSVSVCLFVYICLFLSIYLYIYLSQTLIHNRRTHTHTHNPTSICLIRLSLSLIGVFFLMCHSIIRSASTLHSLTTGWMHSHSHMHANTLSLSLPPSLVSCLSVHSFLLSLSLSLFILSFSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CCH5</accession>
    <name>A0A812CCH5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_36817</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001619">
        <property type="protein sequence ID" value="CAE1269943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CCH5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1269943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="192" mass="22288" checksum="C91F6429A38DA560" modified="2021-09-29" version="1">MDLSLSLFFPLISDLFWSSVLSFQSPSFFFLFTFSFYPPQSLSSRFIQETFFSILPSPFKCFLFPLIFGKNDLPSLYTDIFSILSDIYSHLLYKYYYWASLFLPLSHAIFFLSYSTHFLPLPLVLFPPSFIFLSLFCLSVLQDDLCLSLSSLSSLISFFPPSQKPFSLSLFLFLSLWCCLFFNPCDKRRGTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CFB2</accession>
    <name>A0A812CFB2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_34786</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001484">
        <property type="protein sequence ID" value="CAE1265627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CFB2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
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            <dbReference type="SAM" id="Phobius"/>
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        <source>
            <dbReference type="EMBL" id="CAE1265627.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
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    <sequence length="479" mass="58059" checksum="4DF479E88DF78FA1" modified="2021-09-29" version="1">MPHNIQIRFPFFLYFFLHLVIFRKFTFFLSFFLSVCLQIAIFTFFSFFLSTPRYISFFLSFFLSFFLSFFLSFYTSNIQKIYFLSFFLSFFLDLVIFLSFFLSRPRYISFFLSFFLSFFLSFFLSFFLHLKIYFLSFFLSFFLSFFLSFFLSVCLSMPHNIQIRLPFFLYVLLHFVIFKSFLSFFLSFFLSFFISAFIFLSFSSLYHISVTSSCLQHVICKFLSFFFIYCVRIFLSSFTILFSVSFFPPFLSIRNTLIHCTAHSNFFSSFVSFLLVSVLSFLLRFCLGPCQLFPAWKFNCKKFYTHISKLSFFLSFFLSFLFFSFHSFFLIFLFWFNEQTSFLSFYRIFSCSFLFLFLTIYRSGSLYKISFIYLILSIHSFIFLSIYLIFSDFNIVFFIYLFSQSYYLKLIYFISFYLFHLSIYLLFLLFISSIYLSIYLSIYNLSYCSFLSIYLSIYLLISRLFILSFSIYLSIYLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CG97</accession>
    <name>A0A812CG97_ACAPH</name>
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        <submittedName>
            <fullName evidence="2">TMEM17</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">SPHA_34226</name>
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    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">Farmed</strain>
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    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAE1264374.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="8" xmlns="https://uniprot.org/uniprot">
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    <name>A0A812CIX3_ACAPH</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <organism evidence="2 3">
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        <name type="common">Pharaoh cuttlefish</name>
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        <dbReference type="NCBI Taxonomy" id="158019"/>
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                <person name="Bekaert M."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <source>
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    <sequence length="1591" mass="172022" checksum="E81285B35097CD81" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="7" xmlns="https://uniprot.org/uniprot">
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    <protein>
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    </gene>
    <organism evidence="1 2">
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        <name type="common">Pharaoh cuttlefish</name>
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        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
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        <submittedName>
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            <strain evidence="2">Farmed</strain>
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    </reference>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
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            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <dbReference type="AlphaFoldDB" id="A0A812CKH4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
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        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
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            <end position="27"/>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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        </submittedName>
    </protein>
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            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001624">
        <property type="protein sequence ID" value="CAE1270004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CL48"/>
    <dbReference type="OrthoDB" id="9635126at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134:SF22">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
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        <property type="entry name" value="OS08G0543275 PROTEIN"/>
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    </dbReference>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        </citation>
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        <source>
            <strain evidence="2">Farmed</strain>
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    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <source>
            <dbReference type="EMBL" id="CAE1271513.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
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</entry>
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            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
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        </citation>
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        <source>
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    <comment type="caution">
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    <dbReference type="EMBL" id="CAHIKZ030002029">
        <property type="protein sequence ID" value="CAE1279815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CR90"/>
    <dbReference type="OrthoDB" id="5778218at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15777">
        <property type="entry name" value="CRBN_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.150.20:FF:000007">
        <property type="entry name" value="Protein cereblon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.20">
        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034750">
        <property type="entry name" value="CULT"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51788">
        <property type="entry name" value="CULT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CULT" evidence="1">
        <location>
            <begin position="58"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1279815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="196" mass="21996" checksum="E0B5247DBDB7E339" modified="2021-09-29" version="1">MVVNVVEAGHVTFSFPARSLFPTVSWRDCCFKFTYSLLVACTISNFVSALALSDGLEAFYLVCRQCGHGAALTNNLINVPSSMAYRQRNDTIQGQEETIIQLFRNPEGKYFEVITLSNADVLKVDKAHREESWFPGFSWSICVCPSCGIHLGWHFEATEVDTITGKRQSFFGLILNHLLHQLYADNLIMVPKSYGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CTY2</accession>
    <name>A0A812CTY2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_41727</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002013">
        <property type="protein sequence ID" value="CAE1279198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CTY2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1279198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="233" mass="28887" checksum="1257B8A409F75EE9" modified="2021-09-29" version="1">MMYPVSSIFFFFFFFFFFFFFFFFRVFFFFFFFFRVFFFFRVFFFFFFFFFFFFLLLYYYYYYYYYSLLLFFLLLFFNFIFISSSFSSSSSFPSSPFTLSSSSSSFPFLFSSSTYSFSFSFSSSSSFASFPPPSFSFTLPPFPSSSYFLRFFFNFFFSVFFVVVFTFCLVFFFIFFLSSSPFSSFVFLLLLLYLLPLLLRLRFLLQFFRRHRRLLRLLFHLLSLLLHLLLVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CUV1</accession>
    <name>A0A812CUV1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_41029</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001957">
        <property type="protein sequence ID" value="CAE1278037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CUV1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1278037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="312" mass="37323" checksum="63856739C5AC1647" modified="2021-09-29" version="1">MLATFSRVALELSLSLSLSLFLSLPFYPSFSLFRFNVLATVHIDCISSKRLFVYLSIYLSIYLSIYLCLFFIYLSIYLSIYLSNLFVLSIYLFYLSIYFCLFYLSIYLSISIFYLSHLFLSIYLFIYLSQSLFYLSIYLSIYLSYLSIYLSIYLSIYLSIYLSIPVSFFLSFFLSFFLSFPVSFFLFLSFFFSFLSFFLSFFLSFFFFLSFHFFSFSFLFFFFLSFFFLSFFLSFFLSFCCPFMTSSLSQVFHIYLSIYLSIYLSIYLSIYLSIYLLLIWLTTTVGSRHSFFSIHIYLSIYLSIYLSIYLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CWP1</accession>
    <name>A0A812CWP1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SPHA_43264</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002164">
        <property type="protein sequence ID" value="CAE1282155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CWP1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000298">
        <property type="entry name" value="Cyt_c_oxidase-like_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50253">
        <property type="entry name" value="COX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51225">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="320"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="351"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="382"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="417"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="454"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="484"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="513"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="547"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="Heme-copper oxidase subunit III family profile" evidence="7">
        <location>
            <begin position="178"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="8">
        <location>
            <begin position="283"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAE1282155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="575" mass="72161" checksum="D330009848222ECD" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CY19</accession>
    <name>A0A812CY19_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_43015</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002129">
        <property type="protein sequence ID" value="CAE1281694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CY19"/>
    <dbReference type="OrthoDB" id="6106188at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1281694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="235" mass="26379" checksum="71A5FDB2AD3803AF" modified="2021-09-29" version="1">MFIFSRIQSSYDGENNKPNRFDVNSEIQFSQNSIFINGSSESNMFDVNSDSRCSQGNSNSPPLEIVQTVGNASFASTEDEQSYGEMSVSHMSFDENGVTCNSPLLQQRIDEENHHRNQYGEFYNSNGPDLFTQLINARNQLTSMRNISLPSKSSLVEDVFQMYRYDDDIYSRSLKSKCIATIFEFAVVLLISSAASRAFTKFLHASITLEPRSAKTRAVSFPIPELAPVINAVFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CYQ3</accession>
    <name>A0A812CYQ3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_44106</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002236">
        <property type="protein sequence ID" value="CAE1283520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CYQ3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="351"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="383"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="416"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="448"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="478"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="513"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="543"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="571"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="599"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="623"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="648"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="676"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1283520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="705" mass="86177" checksum="D2C870AB24D9A414" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D065</accession>
    <name>A0A812D065_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_47750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002616">
        <property type="protein sequence ID" value="CAE1289631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D065"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1289631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="249" mass="30920" checksum="07F9C0552055431E" modified="2021-09-29" version="1">MATAPVLSLFSFLFHRFLLLIFSLSFFFFSSYFSLSFFSLSFFLFLFLFFFLFRFLFLFLFFFSFFLFLSFLLSFLSAFFLLSFPLSFLLSFLLSFPLSFSFFSPFFSSFFSSFFSYFLSFFFFFFFFLFFFLFLFFLFLFFFLFFFLFSFFFPFFFLFFFSFFSSFFSSFFSSFFSSLFHLCNFLKFYLLYLSSLNQFGLNLYICPFAFIYLNFYLSIYEIRIWFKPINFLFLSLFFLSIYNNNLKFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D163</accession>
    <name>A0A812D163_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_47467</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002575">
        <property type="protein sequence ID" value="CAE1289095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D163"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1289095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="178" mass="20955" checksum="6973A00D2F974D72" modified="2021-09-29" version="1">MTLHIKFKDTKARIYLSIYLSIYLSIYLSIYLSIYLSIYLSISACLYLSISACLYLSSIIHLSIYLSIYLSIYLISFISIYLSQPSIYYLSIYSSHIYHIYLSIYLLILYHLSIHLFYLFYLSIYLLSIHIYLSIYLSQPVHIYLSIYLSIYLSIYLSIYLSIYLSQSVYVSNSMSVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D1J5</accession>
    <name>A0A812D1J5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">CAMK4</fullName>
            <ecNumber evidence="9">2.7.11.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SPHA_47675</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Farmed</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.17" evidence="9"/>
    <dbReference type="EMBL" id="CAHIKZ030002606">
        <property type="protein sequence ID" value="CAE1289474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D1J5"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004683">
        <property type="term" value="F:calcium/calmodulin-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000026">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="22"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAE1289474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="323" mass="36696" checksum="7B35453599308B3E" modified="2021-09-29" version="1">MKEDSEYWVAESIKDVNFDQKYTMGSELGRGASAVVYCCTHKETQKNWAVKKIVKRPQSRVFTTEIKLLLGLQHENVVRMKEVFETKANIHMILEFAAGGELFDRIVERGSYSERDAAAAFRQIIQGLKYLHENNVIHRDLKPENLLYLTKDEESILKIADFGLSKMITPNIMKMSICGTPSYSAPELLEGKMYDYSADMWSSGVILFILIGGYEPFYAPTDEKIFARILRNQWKFDSPFWDNISSNCKDLVSALLVRDPAKRMSAPEVLKQHWVMGIAAKEEQIVGATERLKSFNARRKLKGAANAVLMATSVMKVSSKAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D2H5</accession>
    <name>A0A812D2H5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_46231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002439">
        <property type="protein sequence ID" value="CAE1286890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D2H5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1286890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="245" mass="28030" checksum="B52BA7E449F7E5E5" modified="2021-09-29" version="1">MNWCVSILKPVPPPSPPAAPPSRRSRYRYIYIREKEKKKERKENVTLKMQRAASTGTCSLVKSPCECVRVCDLIASAPPPKLSLSHSPIISCFLFFLSLFICSLPSLLFFSFFLYFLARSQPKPIRTLFFMTIYAVSIYLSIFVLFNHMLIYLAMSLTVSHCLLLLISFSLLMSIIYLSISYCLSIYLLLSIYLLLSLHVSLNLYYCPSLYLSISYCPSLYLSLIVPLSIYLLLSMSYCLSIYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D3D0</accession>
    <name>A0A812D3D0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SPHA_45891</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002396">
        <property type="protein sequence ID" value="CAE1286261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D3D0"/>
    <dbReference type="OrthoDB" id="9049620at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="793"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="822"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="851"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="878"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="913"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="939"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="965"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="990"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1025"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1060"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1114"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1155"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="377"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="8">
        <location>
            <begin position="441"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="531"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="8"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAE1286261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1275" mass="148143" checksum="76604B568F1BD907" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D400</accession>
    <name>A0A812D400_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_49523</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002846">
        <property type="protein sequence ID" value="CAE1292927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D400"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="293"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="325"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="354"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="391"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="422"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1292927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="443" mass="53598" checksum="6EC290CFC9CA94A1" modified="2021-09-29" version="1">MLKGTPFLSLSIFLSFSLSFFLFLSLLLSLSLSPSFSFSLSFFLFLSLLLSLSLSPSFSFSLSFFLFLSLLRSLSFSPSFSFLSLKIKNFFSLSFFSVFFSLSFFLVFFFLLFFSLCLFFSLLFSLFVFFFLSFFFSLCLFSLCLFFSLSFFFFFSLFLFFFFSLSFFSLCLFSLFFFLFFFFFSLSFFFSVFFCFSFFSLLFFFFFFSLSFFFSLCFFSLSVFFLSVFFLCLEFCLFSLCLFLSFFLSFSLFFSLSFFFSFFSVFFSLFFSLSFFLSFFFFLSFFFSLSFFFFFFFSLFFFFFFFSVFFSLCFFFSLSFFSLSFFFFFFFFSFLSFFSLCLFFLSVFFFSLSFFSLCLFFLSVFFFSLSFFSLCLFFLSVFFFSLSFFSLCLFFLSVFFFSLSFFSLCLFFLSVFFFSLSFFSLFFLFFFLSLFFFSLSFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D547</accession>
    <name>A0A812D547_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_45508</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002346">
        <property type="protein sequence ID" value="CAE1285545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D547"/>
    <dbReference type="OrthoDB" id="8964756at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1285545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="209" mass="24033" checksum="655A658E38D5FA7B" modified="2021-09-29" version="1">MDGMSLDVISSRVMPLSVISNIFQYNVTRRHVPRCNIMQSDVPRCNVNQVMFLAVISSRGISLTKMSHEWDVPRCNIKQSDVPFYNIKQRDIFQYNVTRRHAPRCNIMQSDVPRCNVNQSDVPRCNIKQEDVSRCNIRVMSLAVYLSFNIMSHTLVVTSCRWSLAVMSIRVMFLDVISSRGISLTIMSHGWDVPRCNIKQSDAPFCNIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D7J6</accession>
    <name>A0A812D7J6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_50845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003024">
        <property type="protein sequence ID" value="CAE1295308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D7J6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1295308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="197" mass="23472" checksum="B779994250227ED6" modified="2021-09-29" version="1">MSIDIYCLERDPRPIYLSIYLSIYLSIYLSIKIYFLLFLIYLSIYLSIYLSIYHSIFISIYPIYLSKYVLYLSIYLSIKIFFLSIYLSIYLSIYLSIYLSIYQNLFLIYLSIYLSIYLSIYVLIALSLSLSLFLCPFLAISFSKLFIYSLLSNLNFQTVCCHHFYDLFPLRVFVALRYPPPSRINDPFSGDWQVEMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D7L4</accession>
    <name>A0A812D7L4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_48936</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002767">
        <property type="protein sequence ID" value="CAE1291806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D7L4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="284"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1291806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="321" mass="36899" checksum="51A9D1E5E98CCD05" modified="2021-09-29" version="1">MFLSNFLLFLPISFWSSLFPSLYLLLPSFHFPCFRLPVFSMFLSNFLLFLPISFWSSLFPSLYLLLPSFHFPLFSLPSFPGFSLTFSFFFLSLFWSSLFPSFICFFCLPFTSLVFAFPSFPGFSLTFSFFFLSLFGLLSSPPFICFCLPFTSLVFAFPSFPGFSLTFSFFFLSLFGLLSSPPFICFCLPFTSLVFAFPSFPGFSLTFSFFFLSLFVFSLPLPLFAFAFLSLPLFSLPSFPGFSLTFSFFSYLFFLLSSPPFICFCLPFTSFCFLPVFSRFLSNFLLFFPISFFLLSSPPFICFCLPFTSLVFPSCLFHVSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D8D7</accession>
    <name>A0A812D8D7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NUP205</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SPHA_51241</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NUP186/NUP192/NUP205 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003094">
        <property type="protein sequence ID" value="CAE1296107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D8D7"/>
    <dbReference type="OrthoDB" id="2019644at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044611">
        <property type="term" value="C:nuclear pore inner ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021827">
        <property type="entry name" value="Nup186/Nup192/Nup205"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31344">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31344:SF0">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11894">
        <property type="entry name" value="Nup192"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAE1296107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1229" mass="138359" checksum="422CB13A0973B0AA" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D9V4</accession>
    <name>A0A812D9V4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_52408</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003254">
        <property type="protein sequence ID" value="CAE1298082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D9V4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032368495" evidence="2">
        <location>
            <begin position="18"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="322"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="369"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="413"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="445"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="471"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1298082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="522" mass="61768" checksum="CF09E169D9E439BB" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DAI2</accession>
    <name>A0A812DAI2_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">F-actin-capping protein subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SPHA_52377</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Farmed</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
            <location evidence="1 7">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the F-actin-capping protein beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003250">
        <property type="protein sequence ID" value="CAE1298008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DAI2"/>
    <dbReference type="OrthoDB" id="9979678at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008290">
        <property type="term" value="C:F-actin capping protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051490">
        <property type="term" value="P:negative regulation of filopodium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010591">
        <property type="term" value="P:regulation of lamellipodium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.210:FF:000001">
        <property type="entry name" value="F-actin-capping protein subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.210">
        <property type="entry name" value="F-actin capping protein, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037282">
        <property type="entry name" value="CapZ_alpha/beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042276">
        <property type="entry name" value="CapZ_alpha/beta_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001698">
        <property type="entry name" value="CAPZB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019771">
        <property type="entry name" value="F-actin_capping_bsu_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10619">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10619:SF0">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT BETA ISOFORMS 1 AND 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01115">
        <property type="entry name" value="F_actin_cap_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00192">
        <property type="entry name" value="FACTINCAPB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90096">
        <property type="entry name" value="Subunits of heterodimeric actin filament capping protein Capz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00231">
        <property type="entry name" value="F_ACTIN_CAPPING_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0117">Actin capping</keyword>
    <keyword evidence="5 7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAE1298008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="242" mass="27127" checksum="9F348877BB379B88" modified="2021-09-29" version="1">MTEQQLDCALDLMRRLPPQQIEKNLSDLIDIAPALCEDLLSSVDQPLKVARDKIAGRDYLLCDYNRDGDSYRSPWISEMYFEGGVSSVYLWDLDHGFAGVVLIKKAGDGSKKIKGCWDSIHVMEVQEKSSGKTAHYKLTSTVMLWLLTTKEGSGTMNLGGSLTRQIETDAPVGESSPHIVNIGKMIEDMENKIRNTLNEIYFGKTKDIVNGLRSVMPLQDYKQAEALRNDLVMALQKRPQAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DBW2</accession>
    <name>A0A812DBW2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_53424</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003402">
        <property type="protein sequence ID" value="CAE1299757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DBW2"/>
    <dbReference type="OrthoDB" id="9635126at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1299757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="183" mass="21759" checksum="CF718DEEAF99EF88" modified="2021-09-29" version="1">MSLFSCETIYLLSSCVTIYLSIYLHRNLCSFGTIYVHVKQSIYLYSYETIYLLSSCVTIYLSIYLHRNLCSFGTIYVHVKQSIYLYSYETIYLLSSCVTIYLSIYLSIYLSIYLSIYLSSRESMFIWNYLIPYETIYLHVKVYLYIHVKQSIYLHVDGCLVVLIERKKGQEVVFMKLCWKENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DC25</accession>
    <name>A0A812DC25_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heme-copper oxidase subunit III family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_50219</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002933">
        <property type="protein sequence ID" value="CAE1294104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DC25"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000298">
        <property type="entry name" value="Cyt_c_oxidase-like_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50253">
        <property type="entry name" value="COX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="19"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="338"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="389"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="424"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="463"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="510"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="536"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="578"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="607"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="637"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="672"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="714"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="756"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="785"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="809"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="860"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="domain" description="Heme-copper oxidase subunit III family profile" evidence="2">
        <location>
            <begin position="215"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1294104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="906" mass="106046" checksum="3A06FF6331E52012" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DD44</accession>
    <name>A0A812DD44_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_51127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003076">
        <property type="protein sequence ID" value="CAE1295892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DD44"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1295892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="219" mass="26646" checksum="3FF1A86E60432A40" modified="2021-09-29" version="1">MQQNHQPQPCDPSLQGQYFYSFFFIWHSPFSYYLLFSFYSFSLLIFSLHLFFFSLFLTSYFTYLLYLFTFFFIFSALFSSILKIYFIVSLKFTFLFLIKLPSLFIAHFLIFLLFSSFYLFSFHHIFHFLFLHSLSSHLSFHHYYIILKTIYILFKPFLFVLHFFFSSSHSFFCLPLSLLFTLFIFITNTVSHLFHFFSFFPLPFIATKFSITYFSVDET</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DEY3</accession>
    <name>A0A812DEY3_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Arp2/3 complex 34 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SPHA_51704</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Farmed</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Arp2/3 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
            <location evidence="1 6">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ARPC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003149">
        <property type="protein sequence ID" value="CAE1296894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DEY3"/>
    <dbReference type="OrthoDB" id="148331at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1460.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007188">
        <property type="entry name" value="ARPC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034666">
        <property type="entry name" value="ARPC2/4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12058:SF0">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12058">
        <property type="entry name" value="ARP2/3 COMPLEX 34 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04045">
        <property type="entry name" value="P34-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69645">
        <property type="entry name" value="Arp2/3 complex subunits"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAE1296894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="204" mass="23820" checksum="34FC5339496117FE" modified="2021-09-29" version="1">MVIFFLSLLFFLILFFLTVSISLKFYKELQEHGADALIKREYGDYLTDPEEGYNISLVYDLENIPKDYIEIVKKAALLKRNCFASVFEKYFQFQANGEAGHKRAVIHYRDEETMYVDAQKDRVTVIFSTVFKDDSDVVIGKVFMQEFKEGRRKYQQAPQVLFSHKEPPQELQNTDASVGDNIGYITFVLFPRHTNEQNRIIPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DGH4</accession>
    <name>A0A812DGH4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_52505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003271">
        <property type="protein sequence ID" value="CAE1298258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DGH4"/>
    <dbReference type="OrthoDB" id="6137713at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1298258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="522" mass="57895" checksum="EFD8BDBAE0B393B4" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DGH5</accession>
    <name>A0A812DGH5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_51785</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003164">
        <property type="protein sequence ID" value="CAE1297082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DGH5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1297082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="214" mass="24912" checksum="4BF599FC17FA6D30" modified="2021-09-29" version="1">MLNTSIYLSKETLNTYIYLSIYLKRQTLNTSIYLSIYLSIYLSKETLNTSIYLSIYLLSKETLNTSVGLSIYLCKETLNTSIYLSIYLSIYLSIYLSIDVKYIYLSIEMLNIFIYLSKETLNTSIYLSIFLKRQTLNTSLSIYLSIYLSKETLNTSIYLTIHLSIYLKRKTLNTSIYLSIYLCKGTLNTSIYLSIYLCKETLNTSIYLSIYLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DGR0</accession>
    <name>A0A812DGR0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_51506</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003120">
        <property type="protein sequence ID" value="CAE1296520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DGR0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1296520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="202" mass="23809" checksum="D392736061F3134E" modified="2021-09-29" version="1">MLLTFRVIQTLSRNLLYLSTSPPPLSSSSSLVALFFFFFFFLVALFFFFFFFFFFFFFFFFFFFYSVFFFFPFSFMVFAILLSFSFTSFSSSLLLSISGFSSSSEIKLLLSNHDFFFFLKLFFFFPLNFNLWPSTPISLADLCAFFSPPSYFYIPPVTSLPLFDNPTVPRVRAWPGDEDEDVGAWVLKRVRDRLDLSIYLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DHV7</accession>
    <name>A0A812DHV7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">TPX2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SPHA_57032</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TPX2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003821">
        <property type="protein sequence ID" value="CAE1304460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DHV7"/>
    <dbReference type="OrthoDB" id="1684416at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060236">
        <property type="term" value="P:regulation of mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027329">
        <property type="entry name" value="TPX2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027330">
        <property type="entry name" value="TPX2_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009675">
        <property type="entry name" value="TPX2_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14326">
        <property type="entry name" value="TARGETING PROTEIN FOR XKLP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14326:SF44">
        <property type="entry name" value="TARGETING PROTEIN FOR XKLP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06886">
        <property type="entry name" value="TPX2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12214">
        <property type="entry name" value="TPX2_importin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TPX2 central" evidence="10">
        <location>
            <begin position="150"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="TPX2 C-terminal" evidence="9">
        <location>
            <begin position="324"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="TPX2 C-terminal" evidence="9">
        <location>
            <begin position="438"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="133"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="380"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="458"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="25"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF06886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAE1304460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="532" mass="62235" checksum="1BEA59D1C425C7DB" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DI59</accession>
    <name>A0A812DI59_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_54619</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003559">
        <property type="protein sequence ID" value="CAE1301765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DI59"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1301765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="215" mass="25248" checksum="1D778F17A49ED5E2" modified="2021-09-29" version="1">MISVHSRICYLVLFFYIFLHPVSFTLCYTLFLSFFVIHCFFHDASACFLQFLLPPVSFLFLHVSRFLQPVRFTFPTPCSFHVSYTPFVSRFLQPVSFTFPTPFVSFPTPCSFHVSYTPVRFTFPTPCFFHVSYTPFVSRFLHPRSFHVSYTPVSFTFPTPRFFPSHLPVVHCFFPYQSCILLCPVYFTLCYIPFLSLATRCLFHIANACYFTLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DMB4</accession>
    <name>A0A812DMB4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_58723</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004034">
        <property type="protein sequence ID" value="CAE1306439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DMB4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1306439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="212" mass="25465" checksum="8FC7F2E51B12286D" modified="2021-09-29" version="1">MYCSQITVPFLSLYLFFLPFFLPFFLSFFLSFFYAVPVFLSFFLSFFLSFFLSFFLSFFLSFFLLDNYTAPCLSFFFLSFFLSFFLSFFLSFFLLDNYTAPCLSFSFLSFFLSSFFLSFFLSFFLSFFLSFFFSFISLVSYTVPGLSFLPSFFLSFFLSFFLSSEALDIFHALYAYFLFFYLFLRLNVSIYPNLFNIYLYLSIFYLSIYLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DNR8</accession>
    <name>A0A812DNR8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_59966</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004155">
        <property type="protein sequence ID" value="CAE1307990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DNR8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1307990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="150" mass="17546" checksum="4AA37965F7A828DE" modified="2021-09-29" version="1">MQHLLSHFYHLLDKCNDFLSHCYLLEKCNIFSPFIIFLTNAIIFSLIAIYLKKCNIFSPFLSSIDKCNDFLSHCYLLLKNATSSLHFIIYLTNAMIFSHCYLLEKCNISLSIFIIYLTNAMIFSLFAIFLKNATSSLSIFQIIYRFDKCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DU48</accession>
    <name>A0A812DU48_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_60443</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004208">
        <property type="protein sequence ID" value="CAE1308591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DU48"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1308591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="445" mass="51045" checksum="3C1436B08F994617" modified="2021-09-29" version="1">MSSSNVRSRSFSEHCSLAPVDNVRRQPFFEHCDWYQCSLFEDRPSSTLFLWGQSTMYVDHPSSSIEDERESTTSEADPSLNICSLFEDRPSSTLFLWGQSTMYVDHPSSSIEDERESTTSEADPSLNIVHWRQSTMFEDNPSSNIVTGISAHFSKTVLLRPFFSGASPQLLTFRRPSFFDPFLSGQSAMYVDHPSSSIEDERESTTSEADPSLNIVHWRQSTMFEDNPFFEHCDWYQCSLFEDRPSSTLFLWGQSAMYVDHPSSSIEDERESTTSEADPSLNIVHWRQSTMFSRQCSKTTLLRTLTSEIHNVRSRSFSEHCSLAPVDNVRRQPFFEHCDWYQCSLFEDRPSSTLFLWGQSAMYVDHPSSSIEDERESTTSEADPSLNIVHWRQSTMFEDNPSSNIVTGISAHFSKTVLLRPFSLWGQSAMYVDHPSSSIEDERES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DXV9</accession>
    <name>A0A812DXV9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_64540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004635">
        <property type="protein sequence ID" value="CAE1313346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DXV9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23304:SF189">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23304">
        <property type="entry name" value="SPOT2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1313346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="198" mass="23080" checksum="8F0AEC5D9B5819BB" modified="2021-09-29" version="1">MCARTRSFLLKVPLCISHLSIYLSIYLSIYLSIYLSIYLSLFLSISVCFYLSIYLSIYLSIYLSIYLSIYLSQSVSIYLSIYIYLSLFLSISDVCLSIYLSIYLSIYLSIYLTLFISPPFSLSIYLAYSHITLKNGFSIYLSIYLSIYLSIYLSIYLSLFTIYLSIYLSIYLFEFVNFPSLSISLSRYPSLSLFMKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DZE5</accession>
    <name>A0A812DZE5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_63124</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004529">
        <property type="protein sequence ID" value="CAE1311761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DZE5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="311"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1311761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="352" mass="41694" checksum="EDB748BDE08BB0B8" modified="2021-09-29" version="1">MFTSTISSPPVIKIDLFIVFLFFHYLSIYLSNLISALSIYLSIYLSIYLSISSIYPISALSIYLSIYLIQSLHFLSIYLSISAFSIYLSIYISIYLLSIYLSIYPYLFIYLSIYLSIYLSIYLSIYLILVIISLSHFIWFCLSISILFISVLDSNIYLATTQPDSQQVSSLYLPIDIFFFLSFFLSFCDCLLYSHALPYSEAFTETPLPNAQRHRASSFQQNFFLYLSIYLSIYLSIYLSKSVHLPIKLTQFVPVYLSIYLSIYLSIYLIELLKAYLSYFALSICFYPINNLFLFLSFFLSFFLFYCFFHYILFLCFFFILFSFFLSFFLCLLHYFSIYFFHVCRIREFSRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E1H7</accession>
    <name>A0A812E1H7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_66163</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004770">
        <property type="protein sequence ID" value="CAE1315203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E1H7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="205"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1315203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="255" mass="25627" checksum="60660577BFEE4916" modified="2021-09-29" version="1">MLKVYLILFLNVTCYFLLSFFLSFFLSFFPIAHPLPRLTRSLLLLCGGRRFFVSTLTPHSSSSSSSSSSSSSAAAAAAAVSSFCCCCSSSSAAVFSSTVSSASYSFSSAAFAVSSSSSSAAAASSAAAAVSSSTVSSSSSSSVAAVSSSFSSSSAAAVSSSTSFSSAAAVSSSTTSFSSAAAAVSSTVSSFSSSSAAVLSFSSTVSSSSSSSSSSSSSSSEPIARRPHISTDDFFKILFQFPLFCHSCNKPIYHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E1Y7</accession>
    <name>A0A812E1Y7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_64767</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004671">
        <property type="protein sequence ID" value="CAE1313712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E1Y7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="326"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1313712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="360" mass="40577" checksum="158B6D1E0A074670" modified="2021-09-29" version="1">MFLSIYLSIYLSPFHIYLSIYLSIYLSQFFSYLSIYLSISVLSYLSIYLSIYLSQFFSYLSICLSICLSVRPSFFSCLSVCLSLSVLFISVCLSVCLSQFFSYLSVCLSISLSSFHICLSVYLSQFFSYLSVCLSLSVLFISVCLSVCLSQFFSYLSVCLSLSVLFISVCLSLSVLFISVCLSVYLSQFFSYLSVCLSLSVLFISVCLSVSLSSFHICLSVYLSQFFSYLSVCLSLSVLFISVCLSISLSSFHICLSISLSSFHICLSISQFFSYLSIYISLSISYLSIYLSLSSISYLSIYLSISVNFISIYLSISLLCNKLPHYFMYIIFCSSVCRNLFLSIYLSILFISIYLSISKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E2Q9</accession>
    <name>A0A812E2Q9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_67186</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004867">
        <property type="protein sequence ID" value="CAE1316488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E2Q9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1316488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="175" mass="20618" checksum="3FDC8B76AFC5EF37" modified="2021-09-29" version="1">MSFYFFFSFSVFLFSNLPPPVSNYFPFFFPFSAFLYIFSLLFLILCLSVCLFHSFSYSMSYSLLSFCSLILCPPLYLFSSFLSLFLFPSFSHSLFSFFSIILFLTLFLFPSFSHSIYFSTSFSLLPSLYFLLFLHLGITTIFSLILNFGELYCQDKFLHGEIIFFMVRYSEITMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E503</accession>
    <name>A0A812E503_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_66721</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004817">
        <property type="protein sequence ID" value="CAE1315885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E503"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134:SF22">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134">
        <property type="entry name" value="OS08G0543275 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="308"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1315885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="342" mass="40592" checksum="D2913C7BDBDFB6A4" modified="2021-09-29" version="1">MHDLHAYLSIYLSIYLSICSYLSIYLSIYLSICLSVGLYLSFYLSICLSVCPYLSIYLSLYLSIYLSMHIYIYIYIYIYIYIYLYICLSIHIYLSMHTYISSCLLFSYLSIYLSIYLSIYLSICLSVCSYLSIYLSIYLSVCLFISIYLSIYLCIHIHLSICLSVHYLSIYLSIYLILFISIYLSMPVHIYVTSDLSIYLSIYLSIYICIYIYIYIYIYICLSIHIYLYIHIYLLVFSFHIYLSIYLSVCSYLSIYLSIYLSVCLSVHIYLSIYLSISAYIYIYLSVCLFIIYLSIYLSIYLSIYLSIYLILFISIYLCLFISMSLQIYLSIYLSIYLSIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E797</accession>
    <name>A0A812E797_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_69423</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005077">
        <property type="protein sequence ID" value="CAE1318998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E797"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021741">
        <property type="entry name" value="DUF3311"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40034">
        <property type="entry name" value="BSL5891 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40034:SF1">
        <property type="entry name" value="BSL5891 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1318998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="494" mass="59083" checksum="E20E1189EC072226" modified="2021-09-29" version="1">MNNITFNHHSSFQFHQMTTSFNHHSSFNSDRQHHFQSPFLLPIPPDRQRHIIPPSIPPDSTSFQSPFLQIDKHHFQSPFLLPIPPDRQHHFQSPFLLPIPPDRQHHFQSPFLLPIPPDRQHHFQSPFLLPIPPDRQHHFQSPFLLPIPPDRQHHFQSPFLLPIPPDRQHLSLPIPFLLPIPPDRQHHFQSPFLLPIPPDRQHHFQSPFLLPIPPDRQHHFQSPFLLPIPPDRQHHFQSSFLSIPPDRQHHFQSPFLQTRDNITFNHHSSFQFHQIDNITFNHHSSFQFHQIDNITFNHHSSFQFHQIDNITFNHHSSFQFHQIDNITFNHHSSFQFHQIDNITFNHHSSFQFHQIDNITITFQFQIDNILSITLPIPPDRQHHFFNLLHSSFQFPPDRQHHFQSPFLLPIPPDRQHHFQSPFLLPIPPDRQHHFQSPFLLPIPPDRQHPPSFNHHSSFQFHQIDNITFNHHSSFQFHQIDNITFNHISSFNSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E8H3</accession>
    <name>A0A812E8H3_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Heme-copper oxidase subunit III family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SPHA_66443</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004787">
        <property type="protein sequence ID" value="CAE1315452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E8H3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000298">
        <property type="entry name" value="Cyt_c_oxidase-like_su3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50253">
        <property type="entry name" value="COX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="229"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="307"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="356"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="458"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="503"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="650"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="745"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="domain" description="Heme-copper oxidase subunit III family profile" evidence="3">
        <location>
            <begin position="193"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="536"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="536"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAE1315452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="786" mass="92874" checksum="510CCE58A1EB4E76" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E8I9</accession>
    <name>A0A812E8I9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_70387</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005155">
        <property type="protein sequence ID" value="CAE1320122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E8I9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1320122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="170" mass="20322" checksum="0C69667BEC967807" modified="2021-09-29" version="1">MNSFNSIVRHISIYLSIYLSIYLSIYLSIYLSISLFTSIYFCIYLSTYLYISQSLHIYLSIYLSIYLSICLSIYLSIYIYIYIYIYIYQSLHLCLFMYLSIDLFIYLSVSSYLSIYLSIYLTYSVNSYLSFYLFLYLSIDLSIYFSVSSYLSIYLSIYLSIYLSIYLVFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EBS0</accession>
    <name>A0A812EBS0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_69740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005100">
        <property type="protein sequence ID" value="CAE1319345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="849"/>
            <end position="870"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1319345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="2703" mass="299220" checksum="DB2BDD45D6BED4A0" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EEL7</accession>
    <name>A0A812EEL7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_71210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005210">
        <property type="protein sequence ID" value="CAE1321005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EEL7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="20"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1321005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="200" mass="23063" checksum="740EF2A884C903AE" modified="2021-09-29" version="1">MLCIQGGITLLYEVCPAISLAGLISLSLCLSLSLSLCLSHSLPLIRIFLSIYLSSYLSKSAYIYLSIYLSQFISIYLSQLISIYLISLYLSIYLSKSVYIYLSKSVYIYLSKSVYIYLSNLYLSIYLSQFISIYIYLSQFISIYLSQFISIYLSQFISIYLSIYLSNLYLSIYLSQFISINLSIYLSKSVYIYLSIYLSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EFG6</accession>
    <name>A0A812EFG6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_69947</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005110">
        <property type="protein sequence ID" value="CAE1319547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EFG6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1319547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="270" mass="31371" checksum="943B2B479BA49EE1" modified="2021-09-29" version="1">MCRMDTNLSVCIKYVLRLSARICGGGRLGRHFGHVSGRSETSAQLTIIKSSSPDSPERKSLDMFIFLFFISSRIVVAVVLCHVLISKQSISIYLSIYLSIYLSIYLSHPIHIYLSIYLSIYLSIPSHSLDYLSIYLSIYLSIYLILLSVYHILFIIYLILLNIYLSIYLSNFLILLIIYLPLILLFYLSLYTRTHTYTHTRTNIKDDQKEKTQIELLFSLSNFLLRTYLLTSNLFSFSINHCIYHTSNSIYLSIYLSIYLSIYLSIYLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EGQ3</accession>
    <name>A0A812EGQ3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_72782</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005344">
        <property type="protein sequence ID" value="CAE1322864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EGQ3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134:SF22">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134">
        <property type="entry name" value="OS08G0543275 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="118"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="227"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="254"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="287"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="315"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="398"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="447"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="475"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="505"/>
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    </feature>
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        <location>
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    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
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        <location>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="808"/>
            <end position="832"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1322864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="880" mass="100905" checksum="E722F9E58E7FC7BE" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EHM9</accession>
    <name>A0A812EHM9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_73903</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005398">
        <property type="protein sequence ID" value="CAE1324105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EHM9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="111"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="139"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="172"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1324105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="267" mass="32115" checksum="14D5E0EA25872613" modified="2021-09-29" version="1">MTTVVQSTVMPLLFILTFFTVSLHLSNFLSPIFLCDSFFLSFFLNFFLSFLIYFCPNFIRFFLSFYLCLSLSLSSFYEFDCSSLGIYLSMTFNLFFLSFFLSFFFLPFFLFSSFLSFFFLFFLSFFLSFFLSFSLSIYLSIYLSIRVFVSIFYLSIYLSIYLSVFLYLSIYLSIYLSIYLSIYLSVFCIYLSIYLSIYLSIYLSIYLSIYFYLSIYPCFCIYLSIYLSIYLSIYMFIYLSIYLSIYLSISLSLSLYIYIYIYIYIYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EHN5</accession>
    <name>A0A812EHN5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_71087</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005202">
        <property type="protein sequence ID" value="CAE1320903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EHN5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1320903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="205" mass="23602" checksum="3CC8CC9B8DC1EF2B" modified="2021-09-29" version="1">MLQRTSALVITNVVYTATVEACKMFEQSYGRRLVRVNLSIYLSIYLSIYLSIYLTIYLLLTIYPSIYLSQSFLTYQSIADCAYLSIYLSIYLSIYLAIYLSICCVSTLSMLVLIYLSIYLSIYLSIYLLLSVPACLPIYLSIYLSIYLSIYLSQSFLTYRSIADCAYLSIYLSIYLSIYLSIYACSHLSIYLSIYLSIYLPYITA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EIX2</accession>
    <name>A0A812EIX2_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Spindle and kinetochore-associated protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_76378</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005488">
        <property type="protein sequence ID" value="CAE1326809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EIX2"/>
    <dbReference type="OrthoDB" id="6150664at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="40"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1326809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="369" mass="42130" checksum="1396CFB7162E482A" modified="2021-09-29" version="1">MDGKKLSFFKHFRKLAAHVDRGKNLCTNGELDYQSQTTCINALKKYAEELQEQLVDAKQIYEEQEVSFVKFQSFLDLAEDVIDQQNAIVQSQETFMEQYGYVPYEKSNSEIKQTDDGTQDLETTTSTIEKNVSPEKMSKEVCADGESPETPKLEDFGLSHYTMLQLQKPKMYLNRPVTECIATPTVFQHDGLLMSPSVWGKMPPLYTPDVKNTTQETVGWPEFVASSAKKSAFPFNISKRIWSAFSKPKDYFTEEVPLPPRLNLKIQLRSSPSSINDKPKTQLEAPLTSRYVKSNLDTPSPPVLRTTLSKFDTQLSPDIIPEPVLSCKSQKKDKLSYFEKDIPEPPEVTGIYRYSTRNKENRLAKTKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EJB9</accession>
    <name>A0A812EJB9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_75536</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005463">
        <property type="protein sequence ID" value="CAE1325949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EJB9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1325949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="156" mass="17982" checksum="6540C69EBB4F8FB4" modified="2021-09-29" version="1">MVCSFFLSFPSRALFKGLLTVETAFSLFDIAAFRIRRHLQDVLQARSRLIFSFALRFCFLLFTWSIFKILTFSHYGWNEVIDPLSHLQGQRRFSLKCFNFSQPESIRVNHAVNTLTKREGNGTLCSILGATKSTYLFGFTIFTFSANTGLFILECF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EN15</accession>
    <name>A0A812EN15_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_74234</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005410">
        <property type="protein sequence ID" value="CAE1324478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EN15"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1324478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="175" mass="19074" checksum="3BCEF12E4E766A4A" modified="2021-09-29" version="1">MHQYHLKKKLIHIILSLPLYLSLSLSFSLSPLSLSLSLSPLSLSLSLSFSLLSLSLSSLSLSLSPLSFSPSLLLSLPFSLSPPLSLSPLSLPSPPLSFLSFSLPSLSIPLSLPFSLSLSPPLPLSFSLLSLSPLSFSLLSLSLSIFQIDFSYLSIPSFLFIYLSIYLFIYLSIYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812END2</accession>
    <name>A0A812END2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_74004</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005404">
        <property type="protein sequence ID" value="CAE1324237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812END2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="340"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="364"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1324237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="395" mass="46762" checksum="6C100687A1C1E6FA" modified="2021-09-29" version="1">MSLNASQTLFSTNVICISMYLDASICFSCGSTNTSAATFLSLETLPVFKHKHHHCDLILNLTSLSSFFFSPLSKYLCLSFFTFFLPPLFCYYTFHYYFLFLPHILFSLFLHFLSSSHTFSITFFSISLIFSNFYLPYALLTFSTSLCSPLYFIPFFLLLFFHHSPLSSFFSLLSSPFLYLSYTLFLPFPLTFLFSPLFSPFFILFSLLLPPSPLLSFHLFFLASLCLSYSITFLPFPLLFFFSFFIPLLFHHFSSLFFSSHFFHYHFSLPAFFHFSPTLFLNTPHFQSLMHQDFKPVVHLFFSLIFSFFFLHIYLIIISFSFFSFSFFNPPFFSFSSHSFSLLFSFLFLFFPFILFLFHYYFFLFLPFFFLLIPLFLFLLWLKKQVPLINCASFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ENJ9</accession>
    <name>A0A812ENJ9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_78103</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005529">
        <property type="protein sequence ID" value="CAE1328465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ENJ9"/>
    <dbReference type="OrthoDB" id="9635126at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1328465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="183" mass="21021" checksum="BB038E64D4A439D5" modified="2021-09-29" version="1">MRLQIEAEVGPGVQFYTYFILGVYLIIYLSIYLSIYLSIKFFSVSKAVIISLSLSISFTLSLDSLPIYIRHKRIYLSIYLSIYLSIYLTQFISIYLSVCLSHTAHIYVCLSHCSYLSNCLSVCLSIYLSCTAHIYLSIYLSYTAHIYLSVCLSIYVSIYLTLLISIFLSVYLSHTAHISHMVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EPC4</accession>
    <name>A0A812EPC4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">GHSR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SPHA_76861</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005498">
        <property type="protein sequence ID" value="CAE1327396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EPC4"/>
    <dbReference type="OrthoDB" id="9990906at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF230">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAE1327396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="398" mass="44415" checksum="C5CB032311D8ADDB" modified="2021-09-29" version="1">MFPSDFSSWLTVIITLERAICVCFPIRSHYVFKSGCTIRWIIISIMILGSLNAVDIYFWQYRNRRCYPRHYLQTVFHGTLYSYLPATIIMACNIAIAYKLCRRPTLGRARPQNNGTIGLVLSINVVFVVTTIPFSVVLYFKNYDVEETGAGSSMLYANLVSCVNNAPSDIHPPNILPSTNHPSNIHPPNIHPLNIHPPNIHPSNIHPPNIHPANINPSNIHPSNIHPPNIHPPNIHPLNIHPLNIHPPNIHPPNIHPSNIHPSNIHPSNINPSNIHPSNIHPPNIHPLNIHPLNIHPPNIHPPNIHPSNIHPPNIHPSNIHPSNIHPSNIHPLNIHPSNIHPPNIHPANINPSNINPSNIHPSNIHPPNIHPSNIQPSNILSAIRPCIGYSCHILCTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ESQ6</accession>
    <name>A0A812ESQ6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_79250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005563">
        <property type="protein sequence ID" value="CAE1329863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ESQ6"/>
    <dbReference type="OrthoDB" id="6118569at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="309"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1329863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="396" mass="45489" checksum="E154A325739EC8C0" modified="2021-09-29" version="1">MGSGRTRIARMELSPMFCEYPLPLPESGSKLLLDQCLRLYIRHESLLKKRHVNALSVMPLNELKVKAQWKRCDQSHIQGNQKWTFHWRTLSISAPSWVILDGGAYVGVWKLCLVLQGRAEWDCRSYKEQPDFARASQTFLIIALLCHFACLLIMAIYTSITITCFNKTLTVICLCLITFSAGCMTLMGTIVMGVKAQDYLESLKLQNMRVINNLPSLIDVEITGPIGVGCKVLSSFPYHLSFLCTYFSPLFFFISQFFTFIFSFSVVFSFILPFFSLLVPFLNDILFYSHSSKRSSSVSSSYSLCRYYLFLYFFTFCLFSLCHILCLSFTAISSPPSYMQVYRLTNVCTIDFCTEQPHAEKLASCHYMIFYDILWYYVLYYVSHSPTDLVTGALEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ETH2</accession>
    <name>A0A812ETH2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_79598</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005573">
        <property type="protein sequence ID" value="CAE1330268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ETH2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="362"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="386"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="411"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="441"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="467"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1330268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="490" mass="59250" checksum="7492FDDC34AD544D" modified="2021-09-29" version="1">MKIKNNREVTINIITTTAIIITIATSTITTTIEPLFVSLSSSHLSIYLSIYLSIYLSIYLSKMELNYEPCYKTFSIYEKNNLPCQTCKHLSIYLSLFLSIYLSIYLSIYLSIVYLSISIYLFSIYLSIYLSLFYLSIYLSIYLSIYLSIYLSISVFSYLSIYLSISVFSYPSISVFSYLSIYLSIYLSIYLSISVCSYLSIYLSICIYQISSFFLSFFLSFFLSFFLSFFLLFFLSFFYLFLFVFLSFVHSIFYFFVFFLFSYFFCFSFFPCFFSFIVFSMFVLFSFFLSFFLSIFSFSSLFLPFVILAFFLLIFSFHFFFSFFLSSFLFFFISFFEFFLSFISFIFYIFPYFLFDFFSVRIFSLYSFFFVFFFLFVFLSFFLSFFLSFFLSFFLSFFLCSSFSLSFFLSIFYSLFSLGLSFFFSFFLYFFYVRPFLFPSFFLYFLFSLLSSFFLSMFVLFSFLLSFYIFFFPFFFWSFFFSFFPAYLFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EWZ2</accession>
    <name>A0A812EWZ2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_80888</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005612">
        <property type="protein sequence ID" value="CAE1331755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EWZ2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1331755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="208" mass="23778" checksum="0AD77B3D3AE90434" modified="2021-09-29" version="1">MTNYSPYLSLSICLYISLSLPLFFSLSYSLPLSLTLSFPLSLLLSLPLSLPLSPSLSPSLSFSHFLSPSLSLSLSIYLSIYLSLSLSLSQTIGLACLRIILSLSIYLSIYLSIYLSIYQYLSIYLSIYLSIYLSLLIVSIYLSINIYLSHFVHMHVSIYLSIYLSIYLSKSVHIYLSIYLSIYLSHSLLFTYRYVFLFTLRFLITFID</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AI81</accession>
    <name>A0A812AI81_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_738</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000020">
        <property type="protein sequence ID" value="CAE1141063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        </location>
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        </location>
    </feature>
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        <location>
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            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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            <end position="1087"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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            <end position="1140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1252"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1356"/>
            <end position="1379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1434"/>
            <end position="1454"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1213"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="119"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="192"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="225"/>
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="2">
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            <end position="250"/>
        </location>
    </feature>
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        <location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
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        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
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            <end position="1086"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1103"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1357"/>
            <end position="1379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1141063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1598" mass="179817" checksum="750DABE4340754E0" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ALW9</accession>
    <name>A0A812ALW9_ACAPH</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_257</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
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            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000003">
        <property type="protein sequence ID" value="CAE1138691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ALW9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="21"/>
            <end position="39"/>
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        <location>
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            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="97"/>
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            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="197"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAE1138691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="199" mass="24003" checksum="0B613971E719347A" modified="2021-09-29" version="1">MFSCLCYGVENELLSIYLTDYVHIYLSIYLSIYLSLFYLSIYRSIYLSPFYIYLSISDLFYIYLSISIYLSPFHIYLSIYLIHFISIYLSIYLSIYLSIYFSPFYIYLSIYLSIYLSIYLSQPFFISINLSQSFLYLSIYLSLFISISVLYIYLSIYLSIYLSQSFLYLSIYLSIYLSIYLSPFYIYLSIYLSIYLFRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
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        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">SPHA_2044</name>
    </gene>
    <organism evidence="2 3">
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        <name type="common">Pharaoh cuttlefish</name>
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            <taxon>Decapodiformes</taxon>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000597762">
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            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAE1147236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="179" mass="21931" checksum="773197944A282A38" modified="2021-09-29" version="1">MIFNGISFFLLLSFILSFFLSFFLSFFLSFSRFFFFSFIHSFFFLSLSFDHFLSIFLSFDHFLSFFLSFFLSFFLSFFLSFFLSLAIFASFLSLYFYLHATYSFFLLFSDSFFLSFIRSFFFFFLFLSINFFPFSFLSFFRSFSFVYPFFRSFSFLIFLSLFLSFFVFDVSIYLFPTFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ARZ2</accession>
    <name>A0A812ARZ2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_4400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
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            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000138">
        <property type="protein sequence ID" value="CAE1155096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ARZ2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
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            <begin position="133"/>
            <end position="156"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1155096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="298" mass="35506" checksum="B51D800B9FC1B037" modified="2021-09-29" version="1">MFPSLNSFIHSFFNYFSSFVIPFLMLFDYFYLFFLPLFVLFVSLFIFSPFSFNSSFIIAVFYQSAFTRLPCLTLFDFFLSFINSIIFIFSFSRLLICFLSFIHSFILFYFLLIFFILSFFHQFRHSFFSFNNTLIFFLSFFPFLFPFCPLFSFFLFNHIFLNIFYIFRIFNTFIFLNFLFPSFLPSFLPSFLPSFLPSFLPSFLPSFLRCLVSPPSSISRLQPFSLFSPLRILPFRHGNADADIRWPDMSFPVSNPTGPVPPTKYKFAYPTHLRQKTIPSPPSHHRRFLFPASHSLEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AUM1</accession>
    <name>A0A812AUM1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_7228</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000235">
        <property type="protein sequence ID" value="CAE1162351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AUM1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="12"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1162351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="198" mass="23916" checksum="24F988884AA1FE84" modified="2021-09-29" version="1">MTVLHAEYLTMFRISFFLFIYLSICLSTFLSFFLVVLYFFFFLSFFLSIYLSIFFLSFFYLFFFISIFLSIYLSVCLPFFLFSVVLYFFLSFYLSFYLSFYLSFCLSSVLSFYSFVFLSFYLCFFLSFNLSFCSSAFLSFIYIYLSFFLSFFMSTFLSVFLSNSVYLSFFLSFYLYFCLLLCLSFLFLSIFLVSVFFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AXM3</accession>
    <name>A0A812AXM3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_5679</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000187">
        <property type="protein sequence ID" value="CAE1158707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AXM3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="309"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="369"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="406"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1158707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="470" mass="55299" checksum="120C6C302C575772" modified="2021-09-29" version="1">MVQERSSRFLFLHCLFLVSLSSLSLFSFSFYIFIFLHCLFLVSLSSLSLFNFSSFIFLFLHCLFLVSFSSLSPFSFSFFIFLFLHCLFLISLSSLSLFSFSYFIVTFYFLLLHCLFLISLSPLSHFSFSFFIFLFIHCLFLVYLSSLSLLVSLSSLSLFNFPFFIVSFYFSFFIVSFYFVFLHCHFLVSLSSLSLFIFSFSIFLFLHCLILVSLSSLSLFNFPFFIVSFYFLFLHCHFLVSLTSFFSFFIVSFYFLFLHCHFLVSLSPLSLFNFSYLIFLFLHCHFLVSLSSLSLCSFSFSIVTFSFSYFIFLFLHCFFLLSLSSLSLFSFSFFIVSFQFLFLHYRFLVSLSSLSFVTFYFFIVTFQFLFLHCYFLVSLSSLSLFSFSFFICLFLHCHSLVSFPSLSLFSLSFLIFLFLHCHFLVSPSSVSLFSLSSFIVSFYFLFLHCHFLVSLSPLSLFNFSYLIVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AZ77</accession>
    <name>A0A812AZ77_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_8146</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000263">
        <property type="protein sequence ID" value="CAE1164798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AZ77"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1164798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="242" mass="28470" checksum="4A245CA5067E9EE7" modified="2021-09-29" version="1">MYLTSLPFLSLSHSLYLSIYLPSLSRSFSLSFFLSLSLSLSLSHAHFWILSRLLSQFSRLFFFLLISFKSFFLSLSRVFLSLFLSFFSSSFLFSFFISSLSLFIYLFLSSPRVFLSFFFLQFSFFLSLESFFLSFFLSFFLSFFLSFFLSLESFFLSFFTPFFLSLFILSLSFFLSFFLSFFLFFLSFFLCFFLQFSFFLSFFLCFDLSTILINLSLSLSLSLSLSLSLSLSKEAYSPVRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B0G9</accession>
    <name>A0A812B0G9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="15">CHRNN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SPHA_8555</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Synaptic cell membrane</location>
            <topology evidence="12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000279">
        <property type="protein sequence ID" value="CAE1165729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B0G9"/>
    <dbReference type="OrthoDB" id="5975154at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022848">
        <property type="term" value="F:acetylcholine-gated monoatomic cation-selective channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18997">
        <property type="entry name" value="LGIC_ECD_nAChR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19051">
        <property type="entry name" value="LGIC_TM_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000073">
        <property type="entry name" value="Neuronal acetylcholine receptor subunit alpha-9-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000016">
        <property type="entry name" value="Nicotinic acetylcholine receptor subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002394">
        <property type="entry name" value="Nicotinic_acetylcholine_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00254">
        <property type="entry name" value="NICOTINICR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11 13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="275"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="471"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="14">
        <location>
            <begin position="71"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAE1165729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="500" mass="57045" checksum="8B7B9A8361E82C3F" modified="2021-09-29" version="1">MYLSLSLSLSLSLSLSLSLTLTVLNISRFDYYYYCYYHFLSLFLSLSLSLSLSLSLSLSNSSSFADEVELALVSKLLKNYDKRVRPSLNSSEAINVTFGLALAQIIDVDERNQILTTNCWLNQVWLDVNLRWDPDKYNGIKVIRIPFTDVWKPDILLYNNADVTSYFSSLSSNVIVTSEGNVTWLSMVIFKSSCRIDVRYFPFDEQNCSMQFASWTYDGFQLQLRMNSEEGDISNYIRNNSGEKVTMGITTLLSMTVFMMLVAENMPPTSDVLPLIGIYYGITISIVSFATAMTVFTLNIHHKGARGHEVPVIIKKICFGILAKIFCMRLEKPTNKSSNVFVPCSSQSNSSYIRFKLSNQEESDQNTKPLLEMNPTITQPQSMMRETRFHGDLDTSNGGILSPRFSRLRSLQSRLSSPTHSSSDDFERQFKRVLTKVYQTIERNEIRLAEQDRRDVIKLEWQQVAQMVDRLFLTVFVCVTIIITCIVMFKAPHSTESLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B0R1</accession>
    <name>A0A812B0R1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_7286</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
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        <location>
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        <location>
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            <end position="156"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1162414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="217" mass="26571" checksum="A6E5BE564CC37E98" modified="2021-09-29" version="1">MLAYLIAIFSPFSISFFLSFFLSSFLIYVIYSLLFLVFILTLIFYFFFPSSSHFFFLSFFLSFFLTFSFVLFHFFFLSFFFTFLSFFSLSFSFFLNITTFLFLNISNVFLFLSFLLSFFLSFFSLYFFSFMLLYSSIFTCFFFPLIKLSHFLYFFFSDESFLYLYLFSLNSLLSFFHCLFVPFFVPSFLRLILSFLNNYHDFHFTFSFNRYLFLFHI</sequence>
</entry>
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    <name>A0A812B0Z1_ACAPH</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_10794</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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                <person name="Bekaert M."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
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    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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            <begin position="456"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="596"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAE1169821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="624" mass="71518" checksum="3F31FA78AF511AFF" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B1Y2</accession>
    <name>A0A812B1Y2_ACAPH</name>
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        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase subunit 6</fullName>
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    </protein>
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    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">Farmed</strain>
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    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <source>
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    </evidence>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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            <strain evidence="2">Farmed</strain>
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    <comment type="caution">
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
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            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000382">
        <property type="protein sequence ID" value="CAE1171431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="6251061at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon opus-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055469">
        <property type="entry name" value="DUF7041"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327">
        <property type="entry name" value="ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327:SF3">
        <property type="entry name" value="RNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23055">
        <property type="entry name" value="DUF7041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7041" evidence="1">
        <location>
            <begin position="99"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1171431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="453" mass="50526" checksum="1EF31BE804F76757" modified="2021-09-29" version="1">MTSSILEIMDNWGLASSGLEMQKVSSTKLFLFSLFSNEASFVPPSTPLSILRQEPRQTLPLLGWAVAPRSFRETPYVPLHHMNSSRDDVLLQPRASSSSAVSKLTLEAVQEVRKIISPPKDKPYYKLKEELVRRTSMSRQKKLSQLLHEEQLGDSKPSIELEKHLPSVYHAVLVAVGEDAPVEKLAKIADNVADLTSRCTAPVSAVQTQEPDPLARLLEGQRSPPLLLQFATGKSLGWRPEATRCAGVGEVCRLLFVSDRTTGIRFLVDSGAQISLSPATRTDMLKGPHKLTLQAVNKSLIQTYGQRCLTLNLGLRRVFTHFFVLADVEKAILGADFLHKFVLLIDVHRRCLTDPKTNTQSPGAIHNVILLCPTVANREDNPMFCEHLKKFESITKPSFHKDSLPHNITHHITTSGPLVHSRPRRLAREKNCVTKAEFTQIMELGIIRPSKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B7Q7</accession>
    <name>A0A812B7Q7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_11684</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000387">
        <property type="protein sequence ID" value="CAE1171652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B7Q7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1171652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="252" mass="29404" checksum="8AE613F9EF5E99D6" modified="2021-09-29" version="1">MSKRSNFDWQCQGMGRVGTDKNLGNGNTGIFFINHFLILSIYLSIYLSIYLSIYLSIYLSLSLSLSLYIYIYIYIYIYSLFLPSFLPSFLPSSYLSIYLSIYLSIYLSIYLSIVISLSLSLSMYIYIYICQSVPSFLPSFLLSFLSIYLSIYLSIYLSIYPYFSLSLSLSQNLNPKFYTSIYLSIYLSIYLSIYLSIYPSLFLSIYLSIYLSICQSVLIYLSIYLSIYLSIYLSIYLSIYLQIIQYTNNKMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B8E6</accession>
    <name>A0A812B8E6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_12827</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000429">
        <property type="protein sequence ID" value="CAE1173857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B8E6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1173857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="199" mass="23459" checksum="45EFCBDC2216860E" modified="2021-09-29" version="1">MTGKEIFKVYIFTGMLACIYSNSLPLPLPEEMCHLQCPQETTTSFAWYQDEISSLVCTIYLSIYLSIYLSIYLSIYLILFISIYLSIYLSIYLSHSVHIYLSFSFCSYLSIYLSIYLSISFCSYLSIFLILFISIHLSIYLSIYLFWLVLIYLSVYFGLFLSIYLSMYLSHSVHICLSFYLSHSSLYIYLFIYLFIYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B9Z3</accession>
    <name>A0A812B9Z3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_12413</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000415">
        <property type="protein sequence ID" value="CAE1173056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B9Z3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="328"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1173056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="354" mass="41594" checksum="843A0E8E06CBCADD" modified="2021-09-29" version="1">MIRNRFFFCSIRLRTRTTHPSGTRVHITIQQSPKRPNRGSIYLSIYLSIYLSIYLSIYLSQSVHYLFIHSSSIYLSIYLSIYLRLFIIYLSIYLSIYLSIYLSIYLSIHLSIYLFIIYLSIYLSIYLSISAYSYLSIYLSLFLSIYLSIYLSIYLSIYLSISAYSYIYTSVYPYLSICLSRPIRIYLYIYQSVYHSFIHLFIHLSIYLSIYLSLFIIHLFIYLSIYLSIYLSIYLSISGCSLSIYLSIYLSIYLSISHYLSIYLSIYLSIYLSIYLSQSVPTSVSFSLSLSIAVFCYLSIYLSIYLSIYLSQSVPTSVSFLLSLSLSIYLSVYDIVFGRICLNSDFFFFFFLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BCK5</accession>
    <name>A0A812BCK5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_14908</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000513">
        <property type="protein sequence ID" value="CAE1177894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BCK5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1177894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="214" mass="26231" checksum="FDF8659899AD0191" modified="2021-09-29" version="1">MLSMTWIYSFQSGLFIYFCLFAIYLSIYLSIYLSIYLSIKMDKRETVLILSLFVIYFCLFVIYLSIYLSIYLSIYLSIKMEFLHVPFFLSFFLSFFLSVVNSIFFLSIFLSVYLYFSLPFYLSFFFLSFFLPIYLSIYFYLFISIFLSIYLSFFISFFLYFSFFIPFYLFIFFLSFYLSFFLSIYLSIYLSIYLFLSFYLFLSIFLPFFIQCRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BFQ5</accession>
    <name>A0A812BFQ5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_16644</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000589">
        <property type="protein sequence ID" value="CAE1228001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BFQ5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1228001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="295" mass="36179" checksum="BF08EE7FECEE52AA" modified="2021-09-29" version="1">MRSFFIVSFCLSYYVCFTAFSFLSVFHSYDVFVLSFFHAFFHSFIPSFILSFFRSFFLSFFLSFILSFFSSFRSFLSFFLSFSFFFLAFFLLFILSFFFLSFSFFLSFHSFFFLFFLFLSFFFILFSFVLFFLSFLSFIPSFLSFIPSFILSFLLSFFLSFVLSFFLSFFRSFFLSFFLSFFLSFVLSFFLSYYVYSFLLSVFHSYYVFVSSFFLLFFLSFFLIMYVLLLSFFSFCMSFLLCMFCFCFFLSFFLFFFLSSCVYLLCMLPFFFFHPFFLFMYILSFFLHFIHPFFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BGE1</accession>
    <name>A0A812BGE1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_16248</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000569">
        <property type="protein sequence ID" value="CAE1227064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BGE1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1227064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="199" mass="23592" checksum="B82413AA3A21813B" modified="2021-09-29" version="1">MNRPFKSIFFFIRRITFSLISIKNNQCKFHHSFSLSIYLSIYLSIYLSIYLSIYLSILAIYLSIYLSIYDSRFHNLPMFNQSIFLSIYLSIYLSIYLSIYLSIYFPISIECIDITLFLSIYLSIYLSIYLSIYLSILILNLGPACISNINSYLSLPRHPFYPLKFPFIFHFFFFISDSSLTLWQQETVVMESLQHGFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BH61</accession>
    <name>A0A812BH61_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_17449</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000623">
        <property type="protein sequence ID" value="CAE1229818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BH61"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1229818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="159" mass="18513" checksum="8AB94F0B5BA92A02" modified="2021-09-29" version="1">MSRVISPKLEFGANTKIYLSIYLSIYLSIYLSIYLSISILFISIYLSIYLSIYLSIYLSIYLSNSAHIYLSIYLSIYLSTSVCLYLSIYISIYLSLFITIYLFQSVYNYISIYLSISVCLYLSIYLSLFLSIYLSLHISIYLSIYLYITANFSNSFQIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BJS7</accession>
    <name>A0A812BJS7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_17987</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000646">
        <property type="protein sequence ID" value="CAE1231070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BJS7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1231070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="236" mass="28070" checksum="7F95D460E8EAD2AF" modified="2021-09-29" version="1">MPSPQKNYSKYLSIYLSIYLSYTVHYLSTYLYYTVNIYLSYIVHIYLSTYLSYIVHIYLSIYLSIYLSIYLILFIIYLSTYLSYTGNIYLSIYLSIYLSIYLSIFYCSLSTYLSYTVNIYLSYTVHIYLSIYLSIYLSILYCSLSIYLPIYLILLIYIYLILFISSFIYLSIYLSIYLSIYLILYLSIYLSIYLSIYLIYLMLLIMSVAEFYSTLVIGQRIAQMPVELLFSPSSMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BMR4</accession>
    <name>A0A812BMR4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein GDAP2 homolog,Ganglioside-induced differentiation-associated protein 2,Ganglioside-induced differentiation-associated-protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SPHA_18948</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Farmed</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GDAP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000685">
        <property type="protein sequence ID" value="CAE1233400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BMR4"/>
    <dbReference type="OrthoDB" id="365077at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02905">
        <property type="entry name" value="Macro_GDAP2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035793">
        <property type="entry name" value="Macro_GDAP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11106">
        <property type="entry name" value="GANGLIOSIDE INDUCED DIFFERENTIATION ASSOCIATED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11106:SF72">
        <property type="entry name" value="GANGLIOSIDE-INDUCED DIFFERENTIATION-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13716">
        <property type="entry name" value="CRAL_TRIO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Macro" evidence="3">
        <location>
            <begin position="38"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="336"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAE1233400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="505" mass="58313" checksum="C819362E04AC42FC" modified="2021-09-29" version="1">MEPLGKKQNVVDVADLTRWNFTQLLADEEEKPEDTGSKSPFPWRSDLNSKLVLWKGDILTLQVHALVHPTNEMISTKYEMTARLLQEAGPEMLSEINNSVRGSKTGEARLTKGHQLLARHVIHTVGPRFNVKYSTAAEGALFSCYRSVLQLANENNIRTLAMCPIHSSQRGYPLEQGAHIAIRTVRRFLEKFGSNFETIIFACKENDVMETYQHLMPLYFPRNWKEEMEAKEYLPEDIGNENGEPVIAERKIRIIDKPTFAAFKSLGEEFDETIDLNKEFRSPDGPAVGCHEFAVMKEDIDKERLCTLQAKPSAEQLEKERARLYEKFLLRAKQEDLTDIAQLQCIYQSGVDRFGRPVVVFIGRNLPANCIDMERMLLYIVQMMDPIADNHYTVVYLHSLTTADNLPATSFVKYAYNLLHDKYKKNLSSFYIVHPNIWFKISTWFFTTFTASEIKSRVQHLQGTEYLYAYINTDQFDVPQWVFEYDLKVNGPRYYAPPEDTVDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BNG0</accession>
    <name>A0A812BNG0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_23790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000881">
        <property type="protein sequence ID" value="CAE1243384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BNG0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1243384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="151" mass="17609" checksum="445B332E4500B76F" modified="2021-09-29" version="1">MIYLYQSVYIYLSIYLSIYLSIYLSISITSPSDCSFPFPLIINVFVPYSFAPCNALLFSLLYLSIYLSIYLSIYLSIYLSIYLSKLETCHNCKTSFSCFFLIYLSIYLSIYLSIYLSIYLSKLETSSSFSCFSYIYLSIYLSIYLSIYLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BPA7</accession>
    <name>A0A812BPA7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">GPR89</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SPHA_19230</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Farmed</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>bromide(in) = bromide(out)</text>
            <dbReference type="Rhea" id="RHEA:75383"/>
            <dbReference type="ChEBI" id="CHEBI:15858"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>fluoride(in) = fluoride(out)</text>
            <dbReference type="Rhea" id="RHEA:76159"/>
            <dbReference type="ChEBI" id="CHEBI:17051"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>iodide(out) = iodide(in)</text>
            <dbReference type="Rhea" id="RHEA:66324"/>
            <dbReference type="ChEBI" id="CHEBI:16382"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Golgi pH regulator (TC 1.A.38) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000699">
        <property type="protein sequence ID" value="CAE1234107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BPA7"/>
    <dbReference type="OrthoDB" id="264392at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008308">
        <property type="term" value="F:voltage-gated monoatomic anion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051452">
        <property type="term" value="P:intracellular pH reduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025969">
        <property type="entry name" value="ABA_GPCR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022535">
        <property type="entry name" value="Golgi_pH-regulator_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015672">
        <property type="entry name" value="GPHR/GTG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15948">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 89-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15948:SF0">
        <property type="entry name" value="GOLGI PH REGULATOR A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12430">
        <property type="entry name" value="ABA_GPCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12537">
        <property type="entry name" value="GPHR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="336"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="418"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Golgi pH regulator conserved" evidence="11">
        <location>
            <begin position="134"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Abscisic acid G-protein coupled receptor-like" evidence="10">
        <location>
            <begin position="270"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAE1234107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="447" mass="51582" checksum="8A20A50198CE2CCF" modified="2021-09-29" version="1">MLFSQVLFFAGGWVFFLKQLFKDYEVHRSEILLVFSITFSLSCTMFELIIFEILGILDASSRYFHWKLGLYAILFVLIAILPMHIAYYIVCTIRLVPQKKHARMTLTGVAWCIFLYFFWKIGDPFPILSPKHGIFSIEQCIGRVGVIGVTLMALLSGFGAVNCPYTYMSYFVRYITEADIQSIEKRLIQTMDMIVMKKKRVALAVRENLRQAALNKNQGGFFGMFRNVATTGTSENVSQLKGETHALEELSRQLFLEAVDLHNTRERIEESKTLKGKYFNFLGYFFSIYCVWKIFMSAINIIFDRVGKVDPVTRGTEIAVNYLGIQFDVKFWSQQISFWLVGIIIVTSIRGLLITLTRFFYAIASSKSSNIIVLCLAQIMGMYFVSSVLLMRMNMPVEYRSIITQVLGELQFNFYHRWFEFIFLVSALSSIGFLYIAHQQAPEKNIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BQ30</accession>
    <name>A0A812BQ30_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_21464</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000787">
        <property type="protein sequence ID" value="CAE1238724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BQ30"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="295"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="351"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="411"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1238724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="434" mass="51056" checksum="0B3C537210419B8F" modified="2021-09-29" version="1">MYSFLCFFFVVILISSGKPCLKYFLSFLFHILSDTFSLILTQPHLSIYLSIYLSIYLSISVSFFLFINLSVSFLPSLFLSIYLSIYLSIYLSISVLFFLSINLSRSRSFYQSISLVPSFFVSIYLSIYLSIYFSLVLSIYQSNTVSFFLSINLSQSLSFLLSIYLSIYLSIYLSIYFGFSYSLSIYLSIYLSIYLSIYLSVTYSRNMRGIVVIFHRSFKIYLSIYLSIYLSIYLSMFISIYLSIYLSIYLSIYLSIYLSKVYFYIYLSIYLSYLSIYLSIYLSILVLYSSIHLSIYLSIYLSIYLSILVFTFISIYLSIYLSIYLSVFHIYLSIYLSIYLSIYLSIYPSIYLSVFISIYISVNYFPYLCPIYLSIYLSNYVNIYLISQAVHIYLSIYLSIYLSIYLYRQCFNIYLSIYLSIYLSIYLSVCLSAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BSM4</accession>
    <name>A0A812BSM4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_23244</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000860">
        <property type="protein sequence ID" value="CAE1242326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BSM4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="23"/>
        </location>
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        <location>
            <begin position="30"/>
            <end position="47"/>
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        <location>
            <begin position="171"/>
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        <location>
            <begin position="208"/>
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            <begin position="279"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="314"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1242326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="451" mass="50443" checksum="E152A74081CD2053" modified="2021-09-29" version="1">MYRMAIYLSIYLSIYLSIYLSQSVHYLFRFVYYLSIYLSIYLSIYCGDLPTNRLFHIYIIWLPILSKYRYQISRWSIQDQSSSPLKIYHHPLIGSLSLSHSLFIFLTSSSSSSSSSSSLSPSLSLSLPPSLSLSLSLSGSALPSICTSSLDRFFFFSLRPYHSLCLSLSSSFLALFLPLCPLSLSLSVSLCLSLSLTHTQSHSLSHSLSLYLFLSLSLSFWRIVFLFFHSFFLTHSLFHTLFLTLTSSLPSTLSLFFPLSLSSTLSLYLSTSSVPHSHFLSLLLPLFLSSSLSPSLSLSLSLSHTHTRIHPLSLSLSLSLSLSLSHSLSISLSLSFWRIFFLFSHSFFLSHSNYPFCHFSLTYSHFSSSISLPISFFPPLSLSLSIYFFLTSVVSFHPPLSFPSPLSLIVSLSSSPSLSLHPSSSSSLSFPLSLSRFITLPFPPSHQISFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BU96</accession>
    <name>A0A812BU96_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_23058</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000854">
        <property type="protein sequence ID" value="CAE1241909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BU96"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23304:SF189">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23304">
        <property type="entry name" value="SPOT2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="341"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="369"/>
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        </location>
    </feature>
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        <location>
            <begin position="410"/>
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        </location>
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        <location>
            <begin position="442"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="521"/>
            <end position="544"/>
        </location>
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        <location>
            <begin position="550"/>
            <end position="580"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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            <end position="633"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="690"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="721"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="759"/>
            <end position="784"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1241909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="797" mass="96220" checksum="2411637F5EA9BE7D" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BUR0</accession>
    <name>A0A812BUR0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">OLFR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_22497</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Spiralia</taxon>
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            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000833">
        <property type="protein sequence ID" value="CAE1240819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BUR0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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            <begin position="339"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAE1240819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="371" mass="42932" checksum="BCC22B70B306FC9D" modified="2021-09-29" version="1">MSSFIKYLTTNFLLSSFCANSFCFIYSLSLFLPFSLFLFLTLSLSLFLSFSFLVFLCYTFCLFFPLPLFVCLSFFLSFFHPLFLSVSLSVSLLVSLFFANFFPFLSLFSLFLSVSFSLLSLSLSLSLSLSSLCLCSFFSCSFFFHLFLCDHLFLSFSFFLYLYLLFLVLSFPLFPSLSLSGPRSLSVFLSFLSPPSLSLSLSLSHFIAQFFFLIFTLSLFSLFSSLFLCLSPYGFFSHLLCLSPSFSLSLTNSFSLSFLFLAIYLFTFSFSFSLRTISRSSSSNHFPSLHLHCYFISSFSHSLFFLLSFFLSFASFLYTFIFLFSFFFFFLLPSFFPFLLSFFFVSFVFFLFPFSFPSFFIFDNQFGLTTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BVB4</accession>
    <name>A0A812BVB4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_23607</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
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            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000873">
        <property type="protein sequence ID" value="CAE1243057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        </location>
    </feature>
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            <end position="259"/>
        </location>
    </feature>
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            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1243057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="268" mass="30905" checksum="2848DFD47561A4D9" modified="2021-09-29" version="1">MSPANESTSSLNNGVSRSRERGVQRWRPNSSIFTTLMKDLPSSSCNPEKAIAATIASENQSLEQSYGRFAIFDRSQLDARISYSPTFVFFAIILFFLSFFLSFFLSFFLSFFLSYLSNFLHFPSASLCPPPPPLCFSIVFSFFLHSFLSNDKYVCLKESLLPKYTLIYLSIYLSIYLSIYLSIYLFCSYLSIYLGLFLSIYLSIYLSIYLGLFLSIYLSIYLSIYLSIYLSRSVYIYLSVYLSIYLSIYLSIYLSIYLIHAWTNTGIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BXE3</accession>
    <name>A0A812BXE3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_25906</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000986">
        <property type="protein sequence ID" value="CAE1247907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BXE3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1247907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="202" mass="23435" checksum="FF469C2910B2CAD9" modified="2021-09-29" version="1">MGEMAECKLEERKEFQIDNALSLSLSVCLSVSLSLSLSVSLSVCLSVSLSLSLSLSLSRTIWGEIQKRRPEQFLFISIYLSIYLSIYLSISVCTYLSIYLSIYLSIYLSLFITVYFSLFIIYLSIYLSIYLSIYLSIYLYPVYLSSIPKYLSLYIYLIYLSIIYLSQSVHIYLSIYLSIYLRLYIIYLSIYLSIYLSISLCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BXR2</accession>
    <name>A0A812BXR2_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_26032</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000993">
        <property type="protein sequence ID" value="CAE1248175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BXR2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1248175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="221" mass="25773" checksum="5A9082181AEC45BC" modified="2021-09-29" version="1">MRCRKAKKNRIVCIIRTTKYCAQTPTHTDSLSFPRSLFLFLLLCKSQHTMAGKAKQRRAHQVSSEQTDENRKGETVTGSFVSSRGFVSYVRLLDRKLELFIATVQYVNNFFSPLAFLCFPVLTPIFFLFLSFIHFSCFFLFLNTFFIFPTHLKKTTLPFFSRVFLTLWISSNSIFKLFVQLLYSFFFQFSLCFPNMFSLPVRSSSSFTLPNAFFSSSFSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BYN7</accession>
    <name>A0A812BYN7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_24140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000897">
        <property type="protein sequence ID" value="CAE1244091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BYN7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1244091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="340" mass="40571" checksum="F0B60618878BC904" modified="2021-09-29" version="1">MRTRYKLYIQHLSIYLSIYLSIYPSLFISVYHVSLFISIYLSIYLSIYLSRSVYIFLSIPDYIFRKQPPRSSYFIYFFPSLSLSLSLSLSLSLSLSLSLYFPLHFAFHLFIFLSSFLFPLLFLSHSIFTCTLLLSFSLSSFLSSCYFFLSVSFSLSSVFFFFWAFHLFIFFLSSFPPFLFFVIPFLFALSFFLSFFLSFFFTFSHFHLFIFRSSFLFLLSFTFYLFFFLPFFLSFFLSFFLSFFLSSCYFFLYFFLFHAPLIYINYFLSIPSYAVTFHTLFKTLLPSFLSSFLPSFLRSVNELSPFFLIISRHFFFSGKYSPLSEFSQCFSLNFPVSSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C0Z3</accession>
    <name>A0A812C0Z3_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SPHA_25220</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Farmed</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>tRNA(His) + L-histidine + ATP = L-histidyl-tRNA(His) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17313"/>
            <dbReference type="Rhea" id="RHEA-COMP:9665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78527"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.21" evidence="2"/>
    <dbReference type="EMBL" id="CAHIKZ030000954">
        <property type="protein sequence ID" value="CAE1246564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C0Z3"/>
    <dbReference type="OrthoDB" id="1906957at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004821">
        <property type="term" value="F:histidine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006427">
        <property type="term" value="P:histidyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00773">
        <property type="entry name" value="HisRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00859">
        <property type="entry name" value="HisRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000008">
        <property type="entry name" value="histidine--tRNA ligase, cytoplasmic isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000021">
        <property type="entry name" value="Probable histidine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015807">
        <property type="entry name" value="His-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004516">
        <property type="entry name" value="HisRS/HisZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033656">
        <property type="entry name" value="HisRS_anticodon"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00442">
        <property type="entry name" value="hisS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11476:SF7">
        <property type="entry name" value="HISTIDINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11476">
        <property type="entry name" value="HISTIDYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001549">
        <property type="entry name" value="His-tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="10">
        <location>
            <begin position="64"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="133"/>
            <end position="135"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="333"/>
            <end position="334"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001549-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAE1246564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="519" mass="59035" checksum="FC9FD9D47A3A22E1" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C2V4</accession>
    <name>A0A812C2V4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_26728</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001020">
        <property type="protein sequence ID" value="CAE1249694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C2V4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134:SF22">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134">
        <property type="entry name" value="OS08G0543275 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1249694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="277" mass="32407" checksum="6FB5655C224DD892" modified="2021-09-29" version="1">MPTRFLLLVIFFLSIYLSIYLSIYQFLLLVISIYLSIYLSIYLSVSVCLYLPIYFILFISVYLSVCSYLSIYLSIYLSIYLSIYLSIYLCLYLSMSVYIYLSIYLSIYLSRSVHIYLSIYLSISYLSQYVHIYLSIYLSIYLSTSVCLYLSVHIYFNLSIYLSIYLSIYLVCYYVSMYPSILFVGIPLSPHLSIYLSIYLSIYLSIYLSLFLYLSILLSICLPSPITNPRHPHSKQPRLKLIVQLISFFKFIFVSHSGHSLRLSLSPSLSRSRSRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C2Y6</accession>
    <name>A0A812C2Y6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_27400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001060">
        <property type="protein sequence ID" value="CAE1251121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C2Y6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="310"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="357"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="386"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="445"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1251121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="501" mass="54823" checksum="647AA86D3A5D75DF" modified="2021-09-29" version="1">MTPPPQLTLQQQAVIQHPPSSDPNLDRLQEDTPKLIHQIITDKTTNSYNVKYRPDLNNASSHAGNGQDVSDRNRLTTNNLTDKATQTSKNADNSPSSNNNNSPPPTELETTVNKRRLVSSASVDNGNLSVDAYLSLSLSLLISLSQSVNISLSLSQSVNISLSLSLLISLSLSSVNISLSLSQSVNISLSLSLSLLISLSLSSVNISLSLSLYISLSLSVCSYLSLSLHISLSLCSYLSLSLSHMFSLSLSLSLSLSLFISLSLSVCSYLSLSQFVHISLSLSVCSYLSLSQFVHISLSQFVHISLSLSVCSYLSLSLSLFISLSLSLSLFISLSLFISLSLSSQSVHIYLSQSVHIYLSISVCSYLSIYLSLFISIYLSQSVHIYLSISVCSYLSIYLSLFISIYLSQSVHIYLSISVCSYLSIYLSLFISIYLSQSSISIYPFLFKSISLLICSYLSIYLSVHIYLSVHIYLSICSYFSQSVHIYLPLSLFISISLSVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C305</accession>
    <name>A0A812C305_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_26203</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001001">
        <property type="protein sequence ID" value="CAE1248505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C305"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1248505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="223" mass="24591" checksum="C8E2ABC60F960B11" modified="2021-09-29" version="1">MRPYTDISLSLSLSLSLTHTLSIYLSIYLSICLSLSFSFSLLLKRLSKASYCTPIASVLIWILIDNSSVRTVCVALSFSFSLSLSLSLSLSLSLSLYLSIYLSLSVSPFIDANLSLSLSLSLSLSLSRSLASFSSFSHFPRSQLPGLKTKGIFSPIKSVWKYCTLSVSVSLFSLSSLSLSLSLSLCLSLYLFLSLCLWLQLLLIRNNLPPLTSPSFIFSWMWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C7A9</accession>
    <name>A0A812C7A9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_33931</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001431">
        <property type="protein sequence ID" value="CAE1263913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C7A9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1263913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="223" mass="25028" checksum="1F90266D7A16C4DF" modified="2021-09-29" version="1">MSRISEHSFTSLSLISLATHSPTFPSHIPSSFLSLFLPQLYGQFHFPHHSYIRKVETLIRREREQRQADIKATRTVSSTHTPRGFSGSHNRQCHVSVNILSPSLSLISLATHSPTFPSHIPSSFLSLFLPQLYGQFHFSSYLDFSSSFVPSSLSLSLSLSLSLSLSISFFLVHNINYLSKFGRSLLTTSNGCSYQPARTTHSLSYLCLAPLLPDGMRKFLRFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C7P2</accession>
    <name>A0A812C7P2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_29865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001199">
        <property type="protein sequence ID" value="CAE1255890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C7P2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1255890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="175" mass="20854" checksum="FEEDEFB4D93F7231" modified="2021-09-29" version="1">MSFFLSIFLSFFLSFCPSFFLSFFIYLFLLSLRLYFYFNYASFFFFSFHSFSSFFLSFFLSFFLSFFLYFFHFISPFVFASVFPVGHPVIIHLFSFFLSFFLSFFLSFFLSFCFSRCPPSLFLICLRNILFILAFSLSLFIFPLSSFLFLSVSVCTFLYLSVFLSDSLFLVGNFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C9Y7</accession>
    <name>A0A812C9Y7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_31019</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001258">
        <property type="protein sequence ID" value="CAE1258011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C9Y7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1258011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="286" mass="34978" checksum="A95CA2B532125522" modified="2021-09-29" version="1">MQRFGHDWKCLSILSTNKLPENRSFYLLSRTAVWTEDWKLSKLTSVPPKIILLHIFLSFFLSFSFFLSFFLSFFFLSFFLSFFLSKSFHFSLFFFLFSFFLHFLFLSFFLNHFIFRFLSLFFLSFYIVSSFFPSFFLSYFFRSHIFLLLSYEISSSFPLFLFFIHSFFLSLFVNHFIFPFLSFFLSFFRSFFPSFFKNHVDKNFLRNLFFTCPLSFSLSFFLSFFLSFFLFFSKSLCFLLYNIYLSIYLSIYLFHSFLSSFLNSFFFSFFLSFFLSFFLSFIFSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CBI1</accession>
    <name>A0A812CBI1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_32025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001331">
        <property type="protein sequence ID" value="CAE1260137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CBI1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1260137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="303" mass="34869" checksum="EA6D2A5043FCC7E1" modified="2021-09-29" version="1">MISLSLSPSIASLPFLLMSSSLSLLPFIIFLYFPFILLVFSFILLQSFYSFTFSVFGIFFPASFRISSVSSYTFSFIFVFLRFLLFLILLFLLFSSFISIDFLLHLCFSCLPLLIVLLILPPFLSPFLSLYLFLFFFLIIIFFFFFFLFFFLISLSFHLTPSPSSRTIHLNSLSFLFFHPQPTTYFPRRTPSSTRPDLPDSVLCHLRRFGTTSRHCGRMKTKITASLSCILSLSLSPFNLSLPHFSIYLSYLSIFPPLVPFNLSSLTFQPLSLSFLYLSISPSPDFTFQSLSLFPLPFNLSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CDD6</accession>
    <name>A0A812CDD6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_33852</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001424">
        <property type="protein sequence ID" value="CAE1263657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CDD6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="342"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="371"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="405"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="479"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="525"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1263657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="547" mass="65036" checksum="4BFD669EEC119C28" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CFI6</accession>
    <name>A0A812CFI6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CEP192</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SPHA_34353</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001455">
        <property type="protein sequence ID" value="CAE1264764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6152085at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000242">
        <property type="term" value="C:pericentriolar material"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051298">
        <property type="term" value="P:centrosome duplication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090222">
        <property type="term" value="P:centrosome-templated microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071539">
        <property type="term" value="P:protein localization to centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054085">
        <property type="entry name" value="Cep192-like_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054086">
        <property type="entry name" value="Cep192-like_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054089">
        <property type="entry name" value="Cep192-like_D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054091">
        <property type="entry name" value="Cep192-like_D5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039103">
        <property type="entry name" value="Spd-2/CEP192"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16029">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 192 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16029:SF11">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 192 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22060">
        <property type="entry name" value="Cep192_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22064">
        <property type="entry name" value="Cep192_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22067">
        <property type="entry name" value="Cep192_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22074">
        <property type="entry name" value="Cep192_D5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cep192-like" evidence="2">
        <location>
            <begin position="911"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="domain" description="Cep192-like" evidence="3">
        <location>
            <begin position="1029"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="domain" description="Cep192-like" evidence="4">
        <location>
            <begin position="1166"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="domain" description="Cep192-like" evidence="5">
        <location>
            <begin position="1349"/>
            <end position="1493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="518"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="587"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="684"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="742"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="518"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="603"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="684"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="749"/>
            <end position="758"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAE1264764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1621" mass="178937" checksum="D99C772324422C02" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CGE0</accession>
    <name>A0A812CGE0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="18">PIEZO1_2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">SPHA_34253</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PIEZO (TC 1.A.75) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001447">
        <property type="protein sequence ID" value="CAE1264497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="303066at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027272">
        <property type="entry name" value="Piezo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031334">
        <property type="entry name" value="Piezo_cap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056770">
        <property type="entry name" value="Piezo_THU9_anchor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056769">
        <property type="entry name" value="Piezo_TM1-24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031805">
        <property type="entry name" value="Piezo_TM25-28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056768">
        <property type="entry name" value="THU_Piezo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47049">
        <property type="entry name" value="PIEZO-TYPE MECHANOSENSITIVE ION CHANNEL HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47049:SF2">
        <property type="entry name" value="PIEZO-TYPE MECHANOSENSITIVE ION CHANNEL HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12166">
        <property type="entry name" value="Piezo_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24874">
        <property type="entry name" value="Piezo_THU9_anchor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24871">
        <property type="entry name" value="Piezo_TM1-24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15917">
        <property type="entry name" value="Piezo_TM25-28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23188">
        <property type="entry name" value="THU_Piezo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="179"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="429"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="457"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="482"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="531"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="611"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="637"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="666"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="719"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="830"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="964"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="988"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1016"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1064"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1130"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1155"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1184"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1616"/>
            <end position="1644"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1656"/>
            <end position="1682"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1792"/>
            <end position="1818"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1838"/>
            <end position="1866"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1904"/>
            <end position="1926"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1947"/>
            <end position="1968"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1980"/>
            <end position="2001"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="2013"/>
            <end position="2032"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="2089"/>
            <end position="2113"/>
        </location>
    </feature>
    <feature type="domain" description="Piezo TM1-24" evidence="16">
        <location>
            <begin position="30"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="domain" description="Piezo TM25-28" evidence="14">
        <location>
            <begin position="1110"/>
            <end position="1336"/>
        </location>
    </feature>
    <feature type="domain" description="Piezo transmembrane helical unit" evidence="15">
        <location>
            <begin position="1611"/>
            <end position="1682"/>
        </location>
    </feature>
    <feature type="domain" description="Piezo THU9 and anchor" evidence="17">
        <location>
            <begin position="1794"/>
            <end position="1851"/>
        </location>
    </feature>
    <feature type="domain" description="Piezo THU9 and anchor" evidence="17">
        <location>
            <begin position="1886"/>
            <end position="2111"/>
        </location>
    </feature>
    <feature type="domain" description="Piezo non-specific cation channel cap" evidence="13">
        <location>
            <begin position="2148"/>
            <end position="2223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="402"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1351"/>
            <end position="1428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1450"/>
            <end position="1473"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="1303"/>
            <end position="1333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="403"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1371"/>
            <end position="1381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1386"/>
            <end position="1396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1398"/>
            <end position="1412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF12166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF15917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF23188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF24871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF24874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CAE1264497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="2223" mass="254891" checksum="1A5CB3BF113AF393" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CL90</accession>
    <name>A0A812CL90_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_39300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001813">
        <property type="protein sequence ID" value="CAE1275062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CL90"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1275062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="261" mass="29040" checksum="E327AD78D68A2B16" modified="2021-09-29" version="1">MISVFCLQSQDLSFHFYNLVNLIISLPLFYPSSVSLSLSLSLFPPPSLSFSFSSLSLSLFFTHSWFIEFNALSLESIMLLHLYPVHKLSLSLSLFLSFSFSLSLSLSLSLSSSLSLSLSLSLSLSLSLSLIFSLFFPTPSLTLYRPIYIFKKKTLSLSTSLSFHLSLFPILPLSTSLSLSTSHSFHLSLFPPLSLSFHLSLVPPLSLSISLSFHLFLFPSLTRSTSLSFHPLSLSLSLSLSLSLLRSSRDCVRAYLYFSFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CL97</accession>
    <name>A0A812CL97_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_36933</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001631">
        <property type="protein sequence ID" value="CAE1270165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CL97"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1270165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="175" mass="22249" checksum="163AE384D859D60F" modified="2021-09-29" version="1">MIFFSYLFLFFFLSFFFSFSFLKKFLSFIFLFFFSFHSPSFFLSFFHFFSFSFFFLSFFSFFFPFSFFFLSFFFFFHSFFFLFFLSFFHFSFFLFFFFFLSFSCLFFLSFFLFFHSHFPFSFFFSNLLSSFFFHSHAFFLSFFFKFSCLLSFLFFSFFLSFFHLISFLSFFLFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CMY4</accession>
    <name>A0A812CMY4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_41953</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002024">
        <property type="protein sequence ID" value="CAE1279627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CMY4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1279627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="248" mass="28202" checksum="CCEB7678FEBD0FEE" modified="2021-09-29" version="1">MSIHLHFISFHYHPSIIFFFVHSSAAFLLNYSLIFLFFSSTLVFCFLSFFQIQPFATLHFSLPLFLYASSISRISVSLFLSPFPYITVTSKYFITLYFSLGLFISLNFLTLSLLRILSFCLFVSFFLSPCVISFSSTFFSFSTVFSLSLLLFSLSKSFPSSFPSPSPSISLFRLLSCAVFLTSLPTFSEILYFLSALSLSLRHLFQYFIISFSSLSSLSLSLSLNSFFFSCLSLPFFIFSLSNFPSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CPV3</accession>
    <name>A0A812CPV3_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Gag-pol polyprotein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_37792</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001694">
        <property type="protein sequence ID" value="CAE1272697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CPV3"/>
    <dbReference type="OrthoDB" id="9908684at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053134">
        <property type="entry name" value="RNA-dir_DNA_polymerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559:SF444">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559">
        <property type="entry name" value="TRANSPOSON TY3-I GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1272697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="271" mass="30883" checksum="78E463BE15420FD9" modified="2021-09-29" version="1">MEQRYSRSRPSPDVCPLVKSASAFKKREDWRRRCWCSLFVLRMTVVQASPEKEYRISCSAADDVGSRLVLKRTNAYHVARRSFPWVFTIAQVRTPILGADFLAHFNLSVNMSSLSLEDKTTNITRKGITSIYRSTCISATLPEANGMQDLLQKYSQITTPFRYTETVRHNAEHHIDTTGPPTHSSPRRLRPDKYKLAKDEFQHMLDLGIIKPSSSPYSSPLHMVPKPDSGAWRPCGDFRKLNATTIPDKYPIPHLHDFRSGSAGRHSLHQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CRS5</accession>
    <name>A0A812CRS5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_40950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001949">
        <property type="protein sequence ID" value="CAE1277939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CRS5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1277939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="323" mass="38461" checksum="7EFF559B74B69C30" modified="2021-09-29" version="1">MKYIFLSLSISIYLSSLSIYLSIYLSIFSACRSLSRFDLSIDRQSSLHIYVFFLYSFFFFAPIFFLSFFLSFFLSFFLSFFLSIFLSPMSFSMPSVLSFFLSFFLSFFLSFFLSFFLSLFLFLFLSSIFFHSRFLPTNFFLSFFLSFFLSFFLSLLDPFASFFLSFFLSFFLSYISFCSFLFKPFFIFLSFLSFFLSFFLSSFYCNLSSFLSSFYSFLFFVFNFLLKPFCSLYPIYLSIYLSIYLSIYLFQSVHIYLSIYLSIYLSIYLSIYLSLPFYFLKCSLHFNNLAKYILNDTYQHFSLIISASLPHHSPCSIFPCCSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CS44</accession>
    <name>A0A812CS44_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_39015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001799">
        <property type="protein sequence ID" value="CAE1274675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CS44"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1274675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="204" mass="23790" checksum="67E559B2CC7BB5F2" modified="2021-09-29" version="1">MCSHGQLYTPHRLFYFHYSIGLIFICSHGQYTMYTLSLILFSFPCRVNICLFSRGTVYPPANFIFISVCSHGQYTVYTLPLILFSFPSVLTDNTQCIHSRLFYFHFSIGLIFICSHGQCTRYTLRLILFSFPCRVNIYLFSRATTPPRLFYFHYSIGLIFICSHGQCTMYTLPLILFSFPCRVNIYLSSRATVYPPAYFIFISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CS55</accession>
    <name>A0A812CS55_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_39698</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001862">
        <property type="protein sequence ID" value="CAE1275875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CS55"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1275875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="330" mass="39910" checksum="951BEBAB77E82E00" modified="2021-09-29" version="1">MLEYICFSLHIYLRISHTHSLSIYLSIYLSIYLPTYLSTYLSIYLPIYLSIYLSIYLSIYLSTYLSIYLSIYISLGYFMLHLFLFPFSFLLFLSSANIFFNFEQYITISFNESFFLSFFLSFFLSFFLSFFPSFLQSLFHSFTIDKYLAKLIAFFHCTFMFFFLLSFFISFSFFLSFFLSLSFFLSFFLSSFFLYLIFFFILSFFLSFFLSFIDEHLLSHPFENALCLILSLLNLNRFLSYITYFFFISLFCIRLNPHIFHLSLSFVSDVFLLLPLPPFNLFIHKFSTQPHLHFFHFHFCIFKIPNTSISFFFIYLTRSKHLRADLKHYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CTM1</accession>
    <name>A0A812CTM1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_43073</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002137">
        <property type="protein sequence ID" value="CAE1281820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CTM1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="153"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="270"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1281820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="297" mass="34116" checksum="F6F8447E93A21531" modified="2021-09-29" version="1">MDFSICHTFFHLCQCICFSHFSPYLLFFKQLLPSSHLSIYLFLFIIYLSIYLSLSVYYLSQPALIISIYLPIYLSQSVHLSIYLSIYLSIYLSLTSSSSSSSSSSSSSSSSSSSSSISHQRSLRNSSVNYIMPPWDADRCMQDAQGVISDSDFLFFLLLYLISFLTISNDSLRLEFFFHLLPILLSIYLSISINIYPTLSISKFTSKLLSIYLSIYLISYLSHSIHICLSSHLTQLLSIYLSIYLSIYLSIYLIHISFSSYLSMYRSIYLSLYFIQLIIYQSIYLSISVHIYLLVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CZK2</accession>
    <name>A0A812CZK2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_44316</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002261">
        <property type="protein sequence ID" value="CAE1283882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CZK2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="295"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="330"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="357"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="392"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="417"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1283882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="465" mass="55233" checksum="841EBDF004EC61C4" modified="2021-09-29" version="1">MIFKPGVISQRLLDNLLNGRRNRTRNEGIYNFPIRHTRTQPHLSHPSRSLIHSFSLSIFIPLSVSAYLSIYLSIYLSIYLSWLLYLSIYLSIYLSIYLGFFIYLSIYLSIYLSIYPYLFIYLSIYLSIYLSIYLSILITSYLSIYLFYLSIYLSIYLSIFLYLLSIYLSIYLSIYYLLHLFRYIYLLSIYLSIYLSIYLSIYLSIYLLQFSVFLYNSSYLSIYLSIYLSIYLNLFISIYLLTFYICLSLFLSNSSYLSIYLSIYLSIYLSIYHPCSPSIYLSIYSNLSIYLSQSLIYLLSICSYLSIYFFYICLIFFVSNCHISIYLSSIYLSIYPETVYLSIYLLMFIYLCRSEYVHISIYLSIYLSIYLSMSMFIYLCRSEPCSYLLNSSIYLSIYLSIYLCQCLYISVDQSVFISIYLSIYLSIYLSIYLLNTQLILLQLSLSFYLSHFDDSLTTNGRHQLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D0B2</accession>
    <name>A0A812D0B2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_44141</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002237">
        <property type="protein sequence ID" value="CAE1283573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D0B2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1283573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="298" mass="37754" checksum="75FDB73F7355AAA2" modified="2021-09-29" version="1">MAIFSFFFSLFLSFFLSFFLNRCFLFFLSLTFLLSFHYFIFLITFFLYYFLLFSFPFHSFLIFFIYFFLFIFFFFTLFFSFFFFFFFYFFSFFLSFFFFFLSFCFFFSFFFLFFFLFFLFSFSFFLSFFLPFLFFFLSFFLSNLFSFVSYLPFFYFLSFFLFLLSFLSFFSFFFFFFFFFLFFPFFLSFFFFLLSFFLFLFFSFFLSSFSFFPFLSFFLNRFFPFFLPPSYLLSFLSFFLSFSFFLLIAILLSFSFFLSFFLSFFLSFFIAVFLSFYHSYSYSPFFLSFFPSFFLPFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D0I1</accession>
    <name>A0A812D0I1_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">ATP synthase F(1) complex subunit delta, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">ATP synthase F1 subunit delta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">F-ATPase delta subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">SPHA_47910</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">Farmed</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Subunit delta, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro. With the central stalk subunit gamma, is essential for the biogenesis of F(1) catalytic part of the ATP synthase complex namely in the formation of F1 assembly intermediate.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Component of the ATP synthase complex composed at least of ATP5F1A/subunit alpha, ATP5F1B/subunit beta, ATP5MC1/subunit c (homooctomer), MT-ATP6/subunit a, MT-ATP8/subunit 8, ATP5ME/subunit e, ATP5MF/subunit f, ATP5MG/subunit g, ATP5MK/subunit k, ATP5MJ/subunit j, ATP5F1C/subunit gamma, ATP5F1D/subunit delta, ATP5F1E/subunit epsilon, ATP5PF/subunit F6, ATP5PB/subunit b, ATP5PD/subunit d, ATP5PO/subunit OSCP. ATP synthase complex consists of a soluble F(1) head domain (subunits alpha(3) and beta(3)) - the catalytic core - and a membrane F(0) domain - the membrane proton channel (subunits c, a, 8, e, f, g, k and j). These two domains are linked by a central stalk (subunits gamma, delta, and epsilon) rotating inside the F1 region and a stationary peripheral stalk (subunits F6, b, d, and OSCP). Component of a complex composed at least by ATPIF1, ATP5F1A, ATP5F1B, ATP5F1C AND ATP5F1E.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase epsilon chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002641">
        <property type="protein sequence ID" value="CAE1289927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D0I1"/>
    <dbReference type="OrthoDB" id="270171at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12152">
        <property type="entry name" value="F1-ATPase_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.440:FF:000002">
        <property type="entry name" value="ATP synthase subunit delta, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.15.10:FF:000004">
        <property type="entry name" value="ATP synthase subunit delta, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.440">
        <property type="entry name" value="ATP synthase delta/epsilon subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.15.10">
        <property type="entry name" value="F0F1 ATP synthase delta/epsilon subunit, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00530">
        <property type="entry name" value="ATP_synth_epsil_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001469">
        <property type="entry name" value="ATP_synth_F1_dsu/esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020546">
        <property type="entry name" value="ATP_synth_F1_dsu/esu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048937">
        <property type="entry name" value="ATPD_C_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036771">
        <property type="entry name" value="ATPsynth_dsu/esu_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01216">
        <property type="entry name" value="ATP_synt_epsi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822">
        <property type="entry name" value="ATP SYNTHASE DELTA/EPSILON CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822:SF7">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT DELTA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02823">
        <property type="entry name" value="ATP-synt_DE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21335">
        <property type="entry name" value="ATPD_C_metazoa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51344">
        <property type="entry name" value="Epsilon subunit of F1F0-ATP synthase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="12" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="11" id="KW-0139">CF(1)</keyword>
    <keyword evidence="4" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="167"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase F1 complex delta/epsilon subunit N-terminal" evidence="19">
        <location>
            <begin position="37"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="F1F0-ATP synthase delta subunit C-terminal" evidence="20">
        <location>
            <begin position="121"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00056834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00062932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00070799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF21335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CAE1289927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="195" mass="21366" checksum="9973AD2345085A57" modified="2021-09-29" version="1">MALARHALRFNSLLRHGSRLAVASMPKQTRGYADMAFTFASPGEVYYNNAKVNQVDVPSLSGNFGILPDHVPTLGVLKPGVVTVYETDSTKKYFVSSGSISINEDSSVQILAEEAHPLENLDPAAIRDGMAKAQQEFSTASTDKDKAEAQIALDCYEALQKALDDKLYICINFSLSLSLYLSIYLSIYLSITIYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D391</accession>
    <name>A0A812D391_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase/retrotransposon-derived protein RNase H-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_47953</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002647">
        <property type="protein sequence ID" value="CAE1290002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D391"/>
    <dbReference type="OrthoDB" id="5860913at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051320">
        <property type="entry name" value="Viral_Replic_Matur_Polypro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064">
        <property type="entry name" value="POL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064:SF37">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1290002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="211" mass="23616" checksum="8E50748DEDD4302C" modified="2021-09-29" version="1">MRRDFTWTFTVANVKVPILGADFLAHYALAVHMNPRTLSDTTTNLRVLGTPTRQGSTGISVATCHGREYLDLLTQFTDITLPPKRRFSQATPARSLPATLAYGLKLNLDKCVFGAPSVDFLGHRTDAEGIAPLPDKISSIRDFPTPTFMKQLRRFLGMLNFYRRFIPNCATILQPLMNLLQRRNKDISLEGDALHAFHTAKAALANYTRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D5V4</accession>
    <name>A0A812D5V4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_45824</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002386">
        <property type="protein sequence ID" value="CAE1286156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D5V4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="339"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="362"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="405"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="433"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="458"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="487"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1286156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="504" mass="63055" checksum="80619B84ED478452" modified="2021-09-29" version="1">MSIIINFIYLSIYLSIYLIKTFFFLSFFFLSFAFFFFSFFFSFFFFLSFLFSSFQLSPFSFFHFGALAFLSFRLFFLLFFLFFILEPFLSFFQLRLSCLLFLSFILEPFFNVKTFLQLSSFLSFIFGALFFLIPCLNVKFLSIIFLFFLSFWSPCFVKKLLFNFLFFLSFIFFSLPFFKTSSFSVSFFFSFFSPCLNFSTLRLNCIFFFLFFHFFPFILIFFHLLHCLLFFFLDNFFFQYLFNCLLFFISFFHFLNSRNRLFSFSFLSFFLSFKIFSFWSLFLSFFFLSFFFFLLVFFFLFFFFILEPFSSLFQDFFFLFFFFFFYFFFGIFFFIKFQFFVSIFFFFFFFFLTFFFPCQDFFQLNICLSILFFLSFFLGPFFFISGLISFFLFFRLEPFILMSRLRLNCLFSFFFISFFFLYFFFFFSFQFSFLLPFFFLFSFFFFLFFFFQKNFFNFFLFSFHFFLPFFVKIFISIFIFFFLYNSILALIQDFFQLFFFFLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D7J0</accession>
    <name>A0A812D7J0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_47378</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002557">
        <property type="protein sequence ID" value="CAE1288905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D7J0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1288905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="269" mass="31160" checksum="203AF46B5C3CA390" modified="2021-09-29" version="1">MLNSISTLIFIYLSIYLSIYLSIYLLFLFRSIYLSIYLSIYLSIYLSISFFKHIDIQYELSIYLLSIYLSIYLSISVYSLYISVYSFIIYLSIYLSISVYSLHISVYSFIIYLSIYLSIYLSIYLTPPIRSISQFRLASCNCLFTSSYHSLLRSSSHGLFRSIYLSIYLSIYLSIYLSVTVLLDPSIPLSVSFCLSKSISIYLSIYLSIYLSILHILLFLRISNLPLVSTLIIRRGRLNARHEDACAGCAMQSECFSSIRHDTSTRQMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D9D1</accession>
    <name>A0A812D9D1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_47613</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002591">
        <property type="protein sequence ID" value="CAE1289331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D9D1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1289331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="204" mass="23527" checksum="2F538FA7FE15533C" modified="2021-09-29" version="1">MGSADPTLKPLTHLPQLSLSQKVDVKDEKTFHDLLVNMTTTISASLILVKHEMNQEHKILCQPAVALGVKCHYPNMCKHVSNDHNAIFYCKLHFVHSFLENFQHFLSFKIPGTVVFPTVMDDFISLRKDLFNIFRRWYTMTLLDNTLTQTDFFQKLCFYEEKIEPFSLKNESLSLSVSLPFSVSLPPSLSLYFFHWCSGSTSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DED2</accession>
    <name>A0A812DED2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">NFAT5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SPHA_54649</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003568">
        <property type="protein sequence ID" value="CAE1301825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DED2"/>
    <dbReference type="OrthoDB" id="5346094at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.340:FF:000002">
        <property type="entry name" value="Nuclear factor of activated T-cells 5, tonicity-responsive"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.340">
        <property type="entry name" value="Rel homology domain (RHD), DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008366">
        <property type="entry name" value="NFAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032397">
        <property type="entry name" value="RHD_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011539">
        <property type="entry name" value="RHD_DNA_bind_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037059">
        <property type="entry name" value="RHD_DNA_bind_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12533">
        <property type="entry name" value="NFAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12533:SF7">
        <property type="entry name" value="NFAT NUCLEAR FACTOR, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16179">
        <property type="entry name" value="RHD_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00554">
        <property type="entry name" value="RHD_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00429">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50254">
        <property type="entry name" value="REL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="601"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="domain" description="RHD" evidence="11">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="314"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="449"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="362"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="379"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="458"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAE1301825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="657" mass="72817" checksum="BC3E9F2F611A19C8" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DF14</accession>
    <name>A0A812DF14_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_52979</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003327">
        <property type="protein sequence ID" value="CAE1298971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DF14"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1298971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="243" mass="26794" checksum="1F6488BCACDB46C9" modified="2021-09-29" version="1">MTIQPGGDEVATSPVIENFPLSYVPEGIKSTAKEISRILAWAHIAFALDESWGCFATLVATIIHRNPLSLSLPLSLSLPLSLSLPLSLNSSTHFYLSSILLSFQFIPVGPPYSRFRIICLPSVHAFASIISFAYAFTHSFCLPAFFLSFLTTSKRTVSSPRQTQRPTSQPIPCLLKRKRKPYGQASTCYYRIDPADATDSSLQPEPLCPLIAFINSICPGYAPSQALRHCVHRNHRSFLCSCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DF55</accession>
    <name>A0A812DF55_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_50748</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003010">
        <property type="protein sequence ID" value="CAE1295064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DF55"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1295064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="288" mass="30843" checksum="C86B0FB942FFB2B5" modified="2021-09-29" version="1">MDFLSLSLSLSLPCASLVLSFIAHMLQATPLSLFKILSPSCSVTLFHPFSLSPTWRRFLSLSLPHMAAVFSLSLSRFPLFGGGFLSLSLPHMAAVFSLSLSPTWRRFSLSLPTWRVSLSLSPHMAAVSLSLSHMAAVFSLSLPTWRRFSLSLSPPHGGGFSLSLSPHGGVFLSLSPPTWRFFSLSLSPHGGAFLSLSPPHGGSFLSLSPPHGGGFSLSLSPHMAFSLSLSPPTFLSVSLSLPHMAAVLSLSLSVMCQTTSLYLLKVLCSFPFSLLLSLWLSSSLSFCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DGK0</accession>
    <name>A0A812DGK0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_51423</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003109">
        <property type="protein sequence ID" value="CAE1296361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DGK0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13037">
        <property type="entry name" value="FORMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13037:SF24">
        <property type="entry name" value="POLYCOMB PROTEIN PCL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0945">Host-virus interaction</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="155"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="239"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="267"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="374"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="424"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="462"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1296361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="511" mass="57176" checksum="C6E3E979625A6BA9" modified="2021-09-29" version="1">MALLYLGKAVYSQDKGRQLFFFFFIFFFFFFFFILPPPSLLLLPYPPPPSSSSSSSSLSFSPLLILLILLLLFPPLSSFTFVSSCLFSSSYFFFLLLLLPPPYPSPPPAYSPHSSSSPPSFPSYTFFSSCLFSSGYFLFLLLLLLFLLVPPPPPYFLLLLLLLLLLLLLLLLLLLLLLILLILLLLLPPSPSFPFVSSCLFSSSYFFFFLLLLLLPLIYPSPPPVYSPPSSFSSPSPPSLLILFILLLLFLLPPPPSSSSFSSFSSYFFFILLLLLFILLPLLFPHPPLLPFSSCLFSSSYFFFFLLLLLPYPPPPSSLSFSSSCLLSSLFFFYYLPSFPFFSSCLFSSSYFFFLLLLLPYPPPRSSSSLSSSFFFLILLLLLLLLSLSFSSSCLFSPSFFYSLPHSLSSPPVYSPPLPSSSSSLSYSFFFILLLLPHPSLSRPPLYPPPSSSTSTSSSSPYFSFLLLLLILLTLILIPLLPPPHFISHPVYSPPPSIFNSSQCCRVVLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DHA6</accession>
    <name>A0A812DHA6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_56808</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003794">
        <property type="protein sequence ID" value="CAE1304118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DHA6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1304118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="240" mass="28281" checksum="7D0FD16F2E026F39" modified="2021-09-29" version="1">MSASPYLSIYLSIYLSIYLSACVCLSLRVASLCACYLSIYLSIYLSIYHCLLISIYLSLSSHIYLSIYLSITVFTYLSIYLSIYLSIYHCLRISIYLSIYLSIYLSLFSHINLSIYHCLHISIYHCLLIFIYLSIYLSIYLFIYHCLHISIYLSIYHCLHITIYLSIYLSIYLSITVFSHLFIYLSIYHCLHISIYHCLLISIYLSIYLSIYLSIYLSITVFTYLFIYLSIYLSIYLSIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DHG4</accession>
    <name>A0A812DHG4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">4-hydroxybutyrate coenzyme A transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SPHA_52384</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Farmed</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetyl-CoA hydrolase/transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003250">
        <property type="protein sequence ID" value="CAE1297984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DHG4"/>
    <dbReference type="OrthoDB" id="10250396at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008775">
        <property type="term" value="F:acetate CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006083">
        <property type="term" value="P:acetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.70">
        <property type="entry name" value="4-hydroxybutyrate coenzyme like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1080.20">
        <property type="entry name" value="Acetyl-CoA hydrolase/transferase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1080.10">
        <property type="entry name" value="Glutaconate Coenzyme A-transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026888">
        <property type="entry name" value="AcetylCoA_hyd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038460">
        <property type="entry name" value="AcetylCoA_hyd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046433">
        <property type="entry name" value="ActCoA_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003702">
        <property type="entry name" value="ActCoA_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21432:SF20">
        <property type="entry name" value="ACETYL-COA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21432">
        <property type="entry name" value="ACETYL-COA HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13336">
        <property type="entry name" value="AcetylCoA_hyd_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02550">
        <property type="entry name" value="AcetylCoA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Acetyl-CoA hydrolase/transferase N-terminal" evidence="3">
        <location>
            <begin position="45"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Acetyl-CoA hydrolase/transferase C-terminal" evidence="4">
        <location>
            <begin position="307"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAE1297984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="471" mass="51195" checksum="4510F2981EF9807B" modified="2021-09-29" version="1">MSSLRAFGRISKLLQGPLKCPSRSYYAGTMEPFHPYPDREPNWVSAEEAVSAVKSGMRVFMHGAAATPVTLVDALAEYGKKANLKDVEVIHIHTEGPGTYAKPEYAGIFRSNSLFLGANCRQAVADGRGDVTPIFLGEIPHLFRRKILTLDVAIVSVCPPDNHGFCSLGPSIDCARSALQNAKYIIGLVNKRLPRTFGDGLVHISHFDALVDENRELPEHKEHILSAEEKQIGKLIAENLVHDGATLQMGIGSIPDAVLAQLGNHKDLGIHSEMFSDGVVDLVKTGAVNNSKKVLQTGKIVSSFTVGTRKLYDFLDNNPFVVMCDVAWTNSPAIICQNPRVTAINSCIEVDLTGQVCSDSIGTRIYSGFGGQVDFIRGAALSHDGLGKPIIALASSTKKGVSKIIPYIKQGGGVVTTRAHVHYVVTEWGIAYLFGKTLRQRAYHLIQIAHPDHREALEKAAFERLKTMPVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DJD9</accession>
    <name>A0A812DJD9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_54762</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003595">
        <property type="protein sequence ID" value="CAE1302022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DJD9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1302022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="217" mass="25461" checksum="C3F6AAFF21AE61D0" modified="2021-09-29" version="1">MTRAISAVTIPTKHRQTQANVMNASREQHLTWPTCVPAQKVIHYFIFVSAVSLFRLILFFFVTPLSRSYFCLASLPLSARPPLILLVLFLFFVTPLSRFYFCLASLPLSARAPLILLLLFLFFVTPHSRFPCFLSVSLSAYQHSYFSLFSSFCRLFPSMNMHNPLANNFTTQLFIFFYFFYLKTTAIFHSHLRFFYISLSFFLFLFFCLFQLLIYNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DLV6</accession>
    <name>A0A812DLV6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_58779</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004041">
        <property type="protein sequence ID" value="CAE1306535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DLV6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="322"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1306535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="361" mass="43814" checksum="0A964113D969608D" modified="2021-09-29" version="1">MFDYYKTLPVISDIEKLTFSSLYSSSLYSPLYISSSPFSFHSSSYSFSSFSSSPFSSSFSSCFSSSIPSSSFYFSSSSSNFYFYSSSSFSSSSSSFSSSFSSFAPSSSSLLYSFYRLLLLLLPILFRLLLCLLLRLLSILLLFVFFSSLYSSSYFFLVFFFAFFFFFFVIFFVFFFVEFFFVFFFFFYLFFFILFLFFAFFFFFIFFVIFFFIFFFLVIFFLVIFSSFVFFVFLFFFIFFSVFIFVVFLFVFYSFYFFVFFFFFVFFFFVFYFVFCFVFFFVFFFFSIFCRLRFFRLLFCLLFRFLFLFILLRILFHLLLCIFFLLLLCILLRLPLLLCILFLRLFSSSYSSSSEHDCYPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DM39</accession>
    <name>A0A812DM39_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_57512</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003885">
        <property type="protein sequence ID" value="CAE1305048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DM39"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="284"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="342"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="366"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="396"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="427"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="458"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="488"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="516"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="547"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="580"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="606"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1305048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="625" mass="74424" checksum="9D9F8C04B17CF4E6" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DM62</accession>
    <name>A0A812DM62_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_59188</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004103">
        <property type="protein sequence ID" value="CAE1307121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DM62"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1307121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="292" mass="33519" checksum="654CC97E09537F4C" modified="2021-09-29" version="1">MSPATFLLLYLFLFALFFFFLFLFLFLHFFFIHFFIIIMPLTTCLFLAFFLISCLLTCYFLKANSNNVALSLSLSLSVCLSVCLSVCLSLSLSLSRLLPEKLFLHITNYVFFSRFTFSHFLSLSLSLSLSLSLSLFPPLPLSHSCLFSLKYVFLSHTHSQFPSLLLSNLCVSFYLVTCHFFLSVFLFNAFLPFFTLITSHSLASLCLALSFPRTFFVSLLLPRSYFFFIIILPFFFFIFCPLLFYPLSLSSLSLLSLSLFSSLSLSHFSVFPLISSTHICLTNIVQILRETF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DN90</accession>
    <name>A0A812DN90_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_58181</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
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            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003966">
        <property type="protein sequence ID" value="CAE1305838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DN90"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1305838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="196" mass="21458" checksum="81361E5EBC4B2554" modified="2021-09-29" version="1">MNVTNPTEIQTRLSITLPCLLDCSLSLSLSLSLSLSLSLSLLSPPSPISLSPSLPLSLPPSHSFPPPLSPSLSLPFTSSYLSSLSLPLSPLSSFPLSLSLSLSLYIYIYIYIYIYEDIKQQADTFSFTAHLSLSLSLSLYLSIYLSIYLSFSSIATSTRLPLDFLHLSLSFFLSFFLSFLSLSLSLFLSFSLSLAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DQ15</accession>
    <name>A0A812DQ15_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_60559</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004214">
        <property type="protein sequence ID" value="CAE1308726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DQ15"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1308726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="222" mass="27328" checksum="265DF3D0930FBF5B" modified="2021-09-29" version="1">MPFFSFSCSRFLFLFFFFSFCLFLFLAFSSLLFFFLFSFLFSFSFFIFIFFFLIIYFTSFFFPFSVLFSFSLFLFDSVVFFHLIFSLLFLFSFGLFVFLAFYSFSSFFFFYFHLFSLFCLLFSSFFCLLSFFSFFLSFTSFSFITFFLHFFLFHLYSFLFSALFILFIITFCFHFLFPFFFFCFLSVFFFVLLSSFSFFLFVSVFSFFCILSFFFLSFYLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DS67</accession>
    <name>A0A812DS67_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_61186</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004310">
        <property type="protein sequence ID" value="CAE1309517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DS67"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1309517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="161" mass="19346" checksum="25761B77618D2C7F" modified="2021-09-29" version="1">MDISFSSSSVFSLHFFFLSFFPSCLFFYFFFLFLFFLPSSLILFFIFNFIFFSLRLSVPKTSFFLFLSFFLSFFLSFFLVIPSLRPPFLPLNIHPSFPYSFIRATFLLVLSFFLSFFLSFSFFLSSHPSEFYSLSLFFFLFSLFFLFSFFLLSFSLFPFHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DT66</accession>
    <name>A0A812DT66_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_61859</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004391">
        <property type="protein sequence ID" value="CAE1310272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DT66"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="132"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1310272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="238" mass="27278" checksum="C8C373E1DD197005" modified="2021-09-29" version="1">MEGVSRFLLSFFSFFPSSFLHGFVACLNLARVMDTVGSVSSYQPMAVAMSDLKSRRLISYLYIKWYSDELGKGVEVFGLFISIYLSIYIYLSIYLSFPVCLFLSIYISIYLSIYLSIYLSVCLFVYGYSQDVFLIFLPIFILPSFFLSKTQSIHLLPFLPHSISLSFFVPVFLFPSFYFLCSFVFQYIYYRRLFGLVTPSLIRPETVDFKRSHQTRRLSASPSPVPISGMPGSASVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DUC3</accession>
    <name>A0A812DUC3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_62537</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004476">
        <property type="protein sequence ID" value="CAE1311014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DUC3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="321"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="390"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="426"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="476"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="502"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1311014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="522" mass="60413" checksum="338BB17FC0CF3D6C" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DY60</accession>
    <name>A0A812DY60_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_63764</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004577">
        <property type="protein sequence ID" value="CAE1312492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DY60"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1312492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="153" mass="19279" checksum="367AF5BDEBB35164" modified="2021-09-29" version="1">MHNLFFFLSSFSFFLFFLSFFLSSFFFLFSFLSSFLSFFLSFFLRSFFLSFFRSSFFFFLPPSFYFLSFFLSFFIYLFISSFFLSLFIYFLVFFLNFFLSFFLSFFLTFFLSFFLSFFLRFSLFFHSFFLPFFRRFFLHLSFSFFLLSFFFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DZB9</accession>
    <name>A0A812DZB9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_63441</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004545">
        <property type="protein sequence ID" value="CAE1312099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DZB9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1312099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="335" mass="40087" checksum="0F86155F80E97D31" modified="2021-09-29" version="1">MYLTFVRIFLFPMSVYPTIVRTLTSENILRFPISIYLPIYLFMYLSICIYLSLSNLSHFAYIYLSIYLSIYLSIYLSKVRYSIKSFSLHLRIFIYKLPKSFSTFHTFSKNIYICISFLFDFIQFHHYIFISVYLILFNSIITFSYLSIYLSIYLSIYLILFNSIITFPIYLSIYIYLSIYLILSNSIITFHIYLILLNSIITFYIYIYLILFNSIITFHIYLSIYLSDSIKFHICITFHSSIYLSIYLSIYLSIYLSIYLILFISIFTFAYLSIYLSIYLSIYLSIYLSISFYSFLSSHLHIYLSLYQTLSKCSELAKIKKIKCFPSSYDKHCEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DZQ2</accession>
    <name>A0A812DZQ2_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_63232</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004535">
        <property type="protein sequence ID" value="CAE1311915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10002522at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017124">
        <property type="term" value="F:SH3 domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042622">
        <property type="entry name" value="Znf106"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14435">
        <property type="entry name" value="ZINC FINGER PROTEIN 106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14435:SF2">
        <property type="entry name" value="ZINC FINGER PROTEIN 106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="1450"/>
            <end position="1473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="633"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="839"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="953"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1014"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="417"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="474"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="674"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="695"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="740"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="839"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="955"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="971"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="991"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1014"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1032"/>
            <end position="1045"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1311915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1514" mass="167967" checksum="1E07E236276A2004" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E256</accession>
    <name>A0A812E256_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_63003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004513">
        <property type="protein sequence ID" value="CAE1311619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E256"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1311619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="188" mass="22536" checksum="D1C73A190988410A" modified="2021-09-29" version="1">MLSFFRLSILTSFIFISSPHFKLPSFIFLSSLHFNFLLLSFFHLSILTSFIFLSSVFLSLALIPYFSFSIFISRLSFIFLIPSFIFFSFFPLYFYLSPILSLSMYFLSWLFSFLFLSLIISLRFNFLFLIPYLFLCPFLYISFSFTLILSFSFYLSISFFLLISYSFLFHSFFLFSFSFFVYLLDNIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E4D8</accession>
    <name>A0A812E4D8_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_67844</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004915">
        <property type="protein sequence ID" value="CAE1317265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E4D8"/>
    <dbReference type="OrthoDB" id="6141573at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="25"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1317265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="313" mass="35373" checksum="8F5BA12831F46262" modified="2021-09-29" version="1">MKRFHPVISVHHLRSSPFASVTQSSEETPDAFGLTFSADIIKVNRQLIFTLREWVSSYTVTLLIQNVQRDTLRDTILRTCLQTRPINSPPAVVRTDSASGFKAHTSDKLLRHYNISIEIGSCKNPSSNHVVEKAVQDVEEEILKMDSAEGQVSSASLVIATNRLNARIRSCGLSPRKILYHRNQFTSECISFEDMDLIKLQHHKRLSSSEHCRAPNRSRRDCVDLRVGNIVYLHGDFTKIRSRERYLVSAIQDVWASVRKFAGSQLRAGTHKVCQEQCYKVPSQDDQKLGVTRDHSGGMMKTMIQSCPLPLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E6S0</accession>
    <name>A0A812E6S0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_68851</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005028">
        <property type="protein sequence ID" value="CAE1318405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E6S0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1318405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="342" mass="40401" checksum="EF9A03B96BDF8673" modified="2021-09-29" version="1">MSENIVGRGEMKYLYPSSTLDNFAVTTGISIYLSIYLSIWLVIYLSISICSYLSIDRSISRSFTFIYPSRFLPYLSIYLSIYPSLFISFINYFSLFLCVFLSFSFFLSFVFFLFFVCFFLSFFLSQSFHFFSSIYLSIYLSIYLSIYPSLFMYFIYFLYLFPNLFISFIFSFYLSIYLSIYLSIYLSQSIHVFYLFSLFISQSVHFFYFFLLSIYLSIYLSIYLSIYVSLHITVYLTYPVKIYLSFLSIKLAIYLSIYLSIYLSIYLSIYLSLFISIYLSLFISIISGISQMASVLDRYEWTTCSCYENVRSSLTICGDFNHLIDRQPTVLPSLLTGVFLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E7B7</accession>
    <name>A0A812E7B7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_69470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005079">
        <property type="protein sequence ID" value="CAE1319027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E7B7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="326"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="383"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="418"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="449"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1319027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="494" mass="59511" checksum="CE0520F1B2E7916C" modified="2021-09-29" version="1">MFFSHLAEEPVLHRLPIKRVALNSGRVCLSLCFLYFPIFLLRRHDSRSACQRLCFYFRLFISIYLSIYLSIYLSIYLSIYLLGSFHYLSIYLSIYLSLFIYIYLSLYLSICLICSYLSIYLSIYLSIYLSISLSLFISIYLSIYLSIEKLFYLKKREFFDEGRPRHKFFFLLLIFIFLSFFLSFFLFFLSFFLSFFLSFFLSFLHLLFLVFFPPFFSPFFLFSFFLSFFLFCIFQFSFFLSSFSFLFSIFSPSFFSLSFFLFSFLFSFFLFSFFLSFFLSFFLSFFLSFLLLSFLFLSFFLSFLLSFLLLSFLFLSFFLSSFLFSFFLFSFFLSFFLSFFLSFFSASSNSPSFFPLSPFFSLSFLLLSFLFLSFFLSSFLFSFFLFFFLSFFLSFLLSFLLLSFLLLSFLFLSFFPPFFSPSFFSLSFFLSFFLSFFSPSSFYFHLLSLLHFSFFSFLLLTLLLLFFLSFFLLSFLLHSPTFFPPFFTKYVNET</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E7H2</accession>
    <name>A0A812E7H2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">GPR158</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SPHA_67805</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004911">
        <property type="protein sequence ID" value="CAE1317227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E7H2"/>
    <dbReference type="OrthoDB" id="2129233at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043458">
        <property type="entry name" value="GPR158/179"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32546">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 158-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32546:SF29">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 3 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="290"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="324"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="392"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="433"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="461"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="495"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAE1317227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="519" mass="60290" checksum="BABEAB5906F2F16F" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E859</accession>
    <name>A0A812E859_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_70193</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005136">
        <property type="protein sequence ID" value="CAE1319878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E859"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1319878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="267" mass="30682" checksum="DAD464A987195857" modified="2021-09-29" version="1">MRCFPLSLLPSICPFLHISLYISIYLSIPVSSLYIYLNLFIIYLSIDSNIIIIHLSEFVHYLSIYLSIYLSIYSSIIIIHLSQFVHYLSIYPFIYLSIYSSIINIYLSQFVHYLSIYPFIYLSIPVSSLSIYLNLFIIYLSIHLSIYLSIPVSSLSIYLNLFIIYLSIHLSIYLSIPVSSLSIYLNLFIIYLSIYLSIYLFQRFNKLIIKLSLSLSVCLCLSLSLSLSLSLSLSLSLSLSLSSGCVFHMSLLLTFSLSIFVSSFIMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EAE1</accession>
    <name>A0A812EAE1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_67283</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004872">
        <property type="protein sequence ID" value="CAE1316623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EAE1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="353"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="380"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="417"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="445"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="472"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="498"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1316623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="525" mass="67495" checksum="DB72736A634784B3" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ECD9</accession>
    <name>A0A812ECD9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_68728</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005012">
        <property type="protein sequence ID" value="CAE1318194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ECD9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1318194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="294" mass="36085" checksum="F263AB0111C46FB9" modified="2021-09-29" version="1">MHFYFFHILTSLSLSPLLIIVLSIYLSIYLSIYLSIYHNIYLHLFFLFLSFVLSFFLSFFLSFFLSFSFFLSFFFFFSFSFLFLSFVLSLSFVLSFFLFVYLILFSRSFFFLSFFSSLSSSISFSISFYFFFLSFFLSFFVYLILYLRFLSCYFLSLFFLSFFLSFFIHIFIGFFCVIFFLFFFLSFFLSFFLRIFIGFYIFIFFLSSHIYRFLSRYFFFFLSFFFLSSFLHIFKVSILFFSSFFLFSLFLIFIGLYRVIFFLSFFLSFFLSPHIYKPLSRYLLSFTLLRTNMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EDH4</accession>
    <name>A0A812EDH4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_70653</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005169">
        <property type="protein sequence ID" value="CAE1320321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EDH4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="307"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="338"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="370"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1320321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="400" mass="51036" checksum="BE723C22097F7B84" modified="2021-09-29" version="1">MLISFFFLFWMYSFSFFLSFFLLPFFFLPFSFFFLFLFLSFFLFPTFLLSFFLLPFFFLPFSFFFLFLSFFLSFFLSSFFLLSFLLSFFYFFLSPFFVLFLSFFLSFFYFFFLFSFFFFFLSFYLFFFSFSFFFFFLSFFLPFSLPFSFFPFFFLFPFPFSFFLSFFFSFTFFSFFTFFLSFSSFSFFFLSFFPFPFSYFFLSFTFFFLLFPSSFFFLSFFFLSFFFFLFPFSYFLSFFYLFSFFFSFFFLFFLSFFLPFSFYFFFFYLFLSPFFIFFLFFFLSFFLSFFLSFFFSYFFFLSFFLFFLFFFLSFFFLSFLFFFSFFFLSFFFLSPFFLFSFFLFSFFSFFLSFFSFFLFSFFLPFFLSFFLFFFLSFLFSFLLFFFFLLSFSICYFPFCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EEI4</accession>
    <name>A0A812EEI4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MmuM</fullName>
            <ecNumber evidence="8">2.1.1.10</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SPHA_73747</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Farmed</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.10" evidence="8"/>
    <dbReference type="EMBL" id="CAHIKZ030005388">
        <property type="protein sequence ID" value="CAE1323940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EEI4"/>
    <dbReference type="OrthoDB" id="261426at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008898">
        <property type="term" value="F:S-adenosylmethionine-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033528">
        <property type="term" value="P:S-methylmethionine cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.330:FF:000002">
        <property type="entry name" value="Homocysteine S-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.330">
        <property type="entry name" value="Homocysteine-binding-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003726">
        <property type="entry name" value="HCY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036589">
        <property type="entry name" value="HCY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051486">
        <property type="entry name" value="Hcy_S-methyltransferase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007020">
        <property type="entry name" value="PRK09485.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46015:SF1">
        <property type="entry name" value="HOMOCYSTEINE S-METHYLTRANSFERASE-LIKE ISOFORM 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46015">
        <property type="entry name" value="ZGC:172121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02574">
        <property type="entry name" value="S-methyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82282">
        <property type="entry name" value="Homocysteine S-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50970">
        <property type="entry name" value="HCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 6 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Hcy-binding" evidence="7">
        <location>
            <begin position="89"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="381"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="382"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAE1323940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="399" mass="44670" checksum="DEA09B050505E580" modified="2021-09-29" version="1">MYHDDNQPPYRCHEVSIYDLFSPIQHHVSRVTLVESNVYEQRLFCWKLLYDWSTQAMVTCPFYVHKFTVVIYLDCLQLSLDMTSLNHFLQHRPGGNQYPLTILDGGTGTELIRMGFTNIDDDPLFSAKLLSTNPEAIKEVHKRFYKAGSDIVVTATYQASIEGLQKYIEITSQEAYDLIKKGVLLAKQAAQEVQSECPDRKLLLVAGSVGPYGACLHDGSEYRGDYMGKISIDDLKAWHQPRIKLLMEAGVDLLAIETIPCLAEALAIIDIMNDIPGCRGWITFSCKDGKHTCSGDNFSESINQVMMSKCVVAAGLNCTSPIYVTDLLDTLRPYSVVKPIIVKPNSGEMWDTSHKWHGGVKNVSELAKVWVKNGASWLGGCCRVYPEDITKLKSAVMNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EEW9</accession>
    <name>A0A812EEW9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_71042</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005201">
        <property type="protein sequence ID" value="CAE1320856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EEW9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032671502" evidence="2">
        <location>
            <begin position="33"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="428"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1320856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="457" mass="49946" checksum="0A54C2264906AF69" modified="2021-09-29" version="1">MLHCSDSPILFSFLLSFQSLFLSLSPMNPSSSLSNCQSINSFSRIQSFSFFSLSNPSSFFLSLQSILSFSPIHPLFLSNPSSLSLSPIHPLSSIHPLSLSNPSSLSPIHLLSLSYSSSLSPTHHLSLSNPSSLSLQPILSLSYPSSLSPIHPLSSIHSLSLLSILSFSNPSSFFNTFPLSPIHPLSLQSILFLQYIPPLSPTHPLSPIHPLSPIHPLSSIHSLSLSNPSSLSPIHPLSSIHSLSLSNPSSFFNPFPLFNIPLSLQSILFLQSILSLPIHPLSPIHPLLSPLSINPLSLPNPSSLSLSRQFILSLSLQSILFLHCIPSLSPTHPLSLCLSNPSSWSFQFIPSLYLIHPPSLTHPLSLTHPLSLQSIPSLSNPFNLESFLFVSLQSIFSLQSILFLSPIQPFSLSNPLSFSNLFSLTLQFFFLSFFLSFFLSFFLCLQPISSLSLSLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EH17</accession>
    <name>A0A812EH17_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Leucine-rich repeat-containing protein 69</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_75233</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005454">
        <property type="protein sequence ID" value="CAE1325593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EH17"/>
    <dbReference type="OrthoDB" id="660555at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1325593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="349" mass="40088" checksum="93E2EE578917E476" modified="2021-09-29" version="1">MALAAIIRAANRQNKSLDLSRKDLDQCPSLIGQLTKIEEIKLTNNRLTDLPKEMCLLNKLQLLNIGGNKFAVLPINLQHFTNLRSLIAYNNRIEILPPIVLNSLKNVTLLNLNNNNLKQIPAEIGRLKNLQNFSVDHNQLEELPFELCYLERLENLHLGYNHLISLPEDLGQLWRLKRLILHKNCLQELPASITNCGNLTVLDVASNELRTFPPEFETLPLKQFYYECNPLLQLRPVSSVQEEEVFALKETVARYIMNQMKNNYPNLWHMIITNPESRTILNEGSQCAVCKNFLLNTWLECVKFVATPQKGFKTSSTTDLMPINARLCSYKCFNKRHNFYGIASTTEPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EH67</accession>
    <name>A0A812EH67_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_75309</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005455">
        <property type="protein sequence ID" value="CAE1325685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EH67"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1325685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="257" mass="30011" checksum="6A9EE3229A639690" modified="2021-09-29" version="1">MGLRAANGQLEQVSRSAGHSYARSSARDISRDIARVAEPHVHALLHALIIKSAYLFFCFFRHLFISVLFYSYLSIYLSIYLSIYLSIYLSTVWYRAIYLSIYLSIYSLFFSLFISIYLSIYLSIYLSIYLSSILTNAIPVILFCCTYCLIYDISATLIYLSIYLSIYLSIYLGHYILRVPPEKSDVFKYKSIYLSIYLSIYLSIYLSELLNKNNTIYLSIYLSIYLAQSVHYLSPLFIIYLSIYLSIYLPKSIYIYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EKC5</accession>
    <name>A0A812EKC5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_72796</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005344">
        <property type="protein sequence ID" value="CAE1322881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EKC5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1322881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="208" mass="26230" checksum="09B25532F611D2BF" modified="2021-09-29" version="1">MFSFFYGFCFLFSLFFLSFFFLFSFFIPFRFLSFLVFSSFFLSFFSLFLSFFFLFHFSFLFFSRFPFLFFSYLYVFLSFFFPFPFLSSPFSFLSFFLVFSFIFLSFSFFHSFSFHVFLSFFFLSFPFFFLFFLLLSFCPFFYPFLFSFLSFFFLLFYFAFFFFLFFFLRSPFLSFSVRFFFFISLLFSLFFSFLFFLFFPLFLFIFYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EKE0</accession>
    <name>A0A812EKE0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SESN1_3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SPHA_76183</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Farmed</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a hydroperoxide + L-cysteinyl-[protein] = S-hydroxy-L-cysteinyl-[protein] + an alcohol</text>
            <dbReference type="Rhea" id="RHEA:67124"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:17193"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:61973"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:67125"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sestrin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005483">
        <property type="protein sequence ID" value="CAE1326596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EKE0"/>
    <dbReference type="OrthoDB" id="337464at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070728">
        <property type="term" value="F:L-leucine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016684">
        <property type="term" value="F:oxidoreductase activity, acting on peroxide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071233">
        <property type="term" value="P:cellular response to L-leucine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990253">
        <property type="term" value="P:cellular response to leucine starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016239">
        <property type="term" value="P:positive regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901031">
        <property type="term" value="P:regulation of response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1290.10:FF:000001">
        <property type="entry name" value="Sestrin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006730">
        <property type="entry name" value="Sestrin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12474">
        <property type="entry name" value="P53 REGULATED PA26 NUCLEAR PROTEIN SESTRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12474:SF0">
        <property type="entry name" value="SESTRIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04636">
        <property type="entry name" value="PA26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAE1326596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="440" mass="51110" checksum="29ADE0BB0B5724BC" modified="2021-09-29" version="1">MGVLKAVVTDQNHNEQKVVPVETTDEETKALFVEAFIANNRLDYSTQLMGYHGKYLECFLKTQNHLMRADGPLPFTFRHYIAIMAAGRHKCSYLIRLQATEFLLQGGDADWLKGLEYIPQKLRDLSEINKLLAHRPWLINKNHIEKLTKGSNNWSVSEVTQALIILSHFHTLSGFIFGCGISSEIDDDLGHTYHQSYDDSYENGCHSDDDEQSFDCTDGGIEALLERMKQLTETREETTHEEMLKGFDKVESPNLDLSSSNEVLNATKADILRYVDEPDFTYQDFAKRLNCQEIATFRAQDYSWEDHGFSLANRLYPEIGSLLDEKFRVAYNMTYNTMGDTRDVDTTAFRRAIWNYIHCMYGIRHDDYNYAEVNQLLERNLKAYVKTVTCYPEQVSRKDYDSVMREFKHSEKVHVNLMMLEARLQAELLYSLRAVMRYMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EL95</accession>
    <name>A0A812EL95_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_75716</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005470">
        <property type="protein sequence ID" value="CAE1326136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13037">
        <property type="entry name" value="FORMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13037:SF24">
        <property type="entry name" value="POLYCOMB PROTEIN PCL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0945">Host-virus interaction</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="162"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="292"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="369"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="413"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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            <end position="469"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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    </feature>
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            <end position="536"/>
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    </feature>
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        </location>
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        <location>
            <begin position="1067"/>
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        </location>
    </feature>
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        <location>
            <begin position="1105"/>
            <end position="1126"/>
        </location>
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        <location>
            <begin position="1133"/>
            <end position="1150"/>
        </location>
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        <location>
            <begin position="1165"/>
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        </location>
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        <location>
            <begin position="1271"/>
            <end position="1292"/>
        </location>
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        <location>
            <begin position="1298"/>
            <end position="1319"/>
        </location>
    </feature>
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        <location>
            <begin position="1340"/>
            <end position="1365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1371"/>
            <end position="1397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1404"/>
            <end position="1424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1326136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1447" mass="166663" checksum="7F519D009FEF83F7" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EQ06</accession>
    <name>A0A812EQ06_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_76494</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005491">
        <property type="protein sequence ID" value="CAE1326959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EQ06"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
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        <location>
            <begin position="31"/>
            <end position="56"/>
        </location>
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        <location>
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            <end position="92"/>
        </location>
    </feature>
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        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
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        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
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        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
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        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
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        <location>
            <begin position="252"/>
            <end position="277"/>
        </location>
    </feature>
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        <location>
            <begin position="289"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="322"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="382"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1326959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="400" mass="46878" checksum="AC9794BBCB063173" modified="2021-09-29" version="1">MSLSLSLCLVCYILVVSLLFRNLCSFSLSQFLSFLILLFSFSAFFFSFSFSLLFSISLPPLFNFSFHFFFYPLFIIPPVLFCISPLFFQFFFTPLFQCFLYSLFFLFSLFLLFFSSSFLYCFSFSLSLLSSVSLSSSLCSFSFPSLFSFPFYSSLFSSSIPPSFLVSLFFSLIFSSFPHLFQFVIYPLYQFSVIISFFLPLMISLSLHVYLIPSFSFSFFFSPNIPHYFSFSLSLSSFFYSLFSLLPPFTVSLFSTVVLFFSPLILPSLVLLLLHLLLCFPPPFSHSSIFFCALCLLLLQSLSFFFCLAFSLFIFIQFYFYLLVSIFLLCFSFSGFFSLLIVSFFLIHFHFCAHLSNTLLFFLHFFFLLLFDTFTFFLPRHIYFFLPSCIILVRYFFFCM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EQH3</accession>
    <name>A0A812EQH3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_75527</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Spiralia</taxon>
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            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
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            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005462">
        <property type="protein sequence ID" value="CAE1325937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EQH3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <location>
            <begin position="58"/>
            <end position="85"/>
        </location>
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        <location>
            <begin position="91"/>
            <end position="107"/>
        </location>
    </feature>
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        <location>
            <begin position="114"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1325937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="173" mass="20701" checksum="1AD514AF1E7A0876" modified="2021-09-29" version="1">MVRGSIAYGPRSISKYVNSPVPTDTKPCTLQFIRVNKVQNLILIWLFPFFRSFFIRPFFLFLSFVISFLHLFFLSSSFVLSFFFLSASFPFLFYFCFLSFVFTYFFLSFFQPLFLFLSFFLSFFLSFFLSFFLSFFLSTFLLLCPFLLFLFSFLSLSVFLSFFLSFFLSFFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ESR8</accession>
    <name>A0A812ESR8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_79703</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005575">
        <property type="protein sequence ID" value="CAE1330362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ESR8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1330362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="248" mass="29795" checksum="0B87338EDEA66D42" modified="2021-09-29" version="1">MHFLFLRFSLSFSLSLSLSLYVPFSLFSFFFYRSFPLLSFFLSFYFPFLYLSIYLSIYLFSTSLYFPCSFPFFLIFLFYFSFRFFFFQFRFLSFSRFIHLFIISFFLFLFSLFLTFLSFPPFFHSFLSLTFLSFFLSVFLSFFLSFFLSFFLSFFLSTPFFLSLFFLSFLSLSLPPSCLPTPPTNPPPSPFYSKLPPHPPFAFSPRIDNMYLCNSTPFITNAIFFWRGKRGRWLKTGKTWRVVVEGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ESS9</accession>
    <name>A0A812ESS9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_76371</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005488">
        <property type="protein sequence ID" value="CAE1326795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ESS9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1326795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="251" mass="27336" checksum="ABCC90352614C51A" modified="2021-09-29" version="1">MLLLIERGIGRKEILRVIASPYCLLTTTGSLTISEHVVVPHPKFFSFFLFSSEKINSLSFFHSSYLRKWESYVSLSLSLSHTHNTLSLSRSLLFETSLSFIPPSSFPSASSSAPTFAVPFTSSVPSSPVLPASPSSPSFLPSLVAPLLFSLSLSTLECTKKAVGRSLVPDPVVASLAAPCECDGLLQKRRAFTQYYLTAYSNLIYDTVLECPSFHPPSVPLKCGPRNPTISTPDRGLNPSRVNGPHSINRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EUG3</accession>
    <name>A0A812EUG3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MX1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SPHA_79055</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Farmed</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005555">
        <property type="protein sequence ID" value="CAE1329480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EUG3"/>
    <dbReference type="OrthoDB" id="6116577at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031623">
        <property type="term" value="P:receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016185">
        <property type="term" value="P:synaptic vesicle budding from presynaptic endocytic zone membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019762">
        <property type="entry name" value="Dynamin_GTPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF231">
        <property type="entry name" value="INTERFERON-INDUCED GTP-BINDING PROTEIN MX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00410">
        <property type="entry name" value="G_DYNAMIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="Dynamin-type G" evidence="5">
        <location>
            <begin position="278"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAE1329480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="636" mass="72440" checksum="4E995B928EAD5F96" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EV38</accession>
    <name>A0A812EV38_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_79224</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005562">
        <property type="protein sequence ID" value="CAE1329844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EV38"/>
    <dbReference type="OrthoDB" id="10217289at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1329844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="447" mass="50805" checksum="B4E1C40016595073" modified="2021-09-29" version="1">MLVKDYSHDDQGHYFHDDEGPCSPDDQGLCSHDDQDTIPIVIKDTVPMMIKDTVPLTMDTVPMMIKDSVPMMIKDTVPMMIKDTIPMMIKDTIPIVIKDTIPMLVKDYSHDDQGHYFHDDEGPCSLMIKDSVPHDDQGHYSHCDQGHYSHDDQGHYSHCDQGHYSHVGQGLFHDDQGHYFHDDEGPCSPDDQDSVPMMIKDTIPIVIKDTIPMMIKDTIPIVIKDTIPMLVKDYSHDDQGHYFHDDEGPCSPDDQGLCSHDDQEHYSHEDQGHCSHYDQGHYSHYDQEHCSHYDQGHYSHDDEGHCSPDDQLDCSYDDQEHYSHDDQGHCSPNDGHCSHDDQGHCSHDDQGHCSHDDQGHYSHCDQGHYSHDDQGYCSHDDQGHCSHDDQGHCSPNDGHCSHDDQGFCSHDDGHCSHDDQGLCSHDDQGHCSHDDQGHYSHCDQGHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EVH9</accession>
    <name>A0A812EVH9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_78524</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005543">
        <property type="protein sequence ID" value="CAE1328930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EVH9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
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            <begin position="163"/>
            <end position="183"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="235"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="334"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="411"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1328930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="439" mass="52624" checksum="08DBE9F254B185C0" modified="2021-09-29" version="1">MTVGIDTSGSIFVIYLSFLSSLFLLLFISFSFLIFISESNFPIFLVFIYFSLNSSFFFLYLSSLITFSFLFLFIFLLSLSYPFFLLLYFFLSFVLFFSFFFCSFIYHFKVCSFHLISFFLACFFFLLLTFDLSIFGVFFLSFFTSLSFFLYLFFYFYFFSPPFFLSLFLSLVLSIDLIFFRSLILSFSHFLPFFLSLFPLFFFLFIPFWIFFFLFIPFLNFFSILIYPFCVSFFLSFSYFGLVFMLCFFAFFLLFFCFLGWGGYSSFFLVLSFSFIYIFGVFPSFLFFLPLFSFSFTLVSLSLPRRRNLFHISFFFFSFFFHFLAFSSPLSPCIHFLVSIFSFLFCLSFFIFLFILLSLLAFTLIPSCNIFLLFYVFSLLLVHSLCPFFYLPFMTFKIFPAHSFFSLSFFFLFYISFSFINHAFLCFNGLVTHDFIKFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EVN9</accession>
    <name>A0A812EVN9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_80211</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005594">
        <property type="protein sequence ID" value="CAE1330964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EVN9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1330964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="181" mass="21219" checksum="EA948FE0B19B8901" modified="2021-09-29" version="1">MGLDPCDDHRNGKPVDHQLIDSPADSLSLSLSLSLSLSLSNMSTAKGIDFFLPGIILRFLTLIGELILSFLLSFFFLSFFFFLFLLLLNSFFSSFFFLSFLLSFLFFNCFFFFLLFLLCLSFFLLFLSFLLSFLLSFSFFLFILLLNSFFLSFFYLSFLRPFSFFSFFLSFFFFLSFYSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ALR0</accession>
    <name>A0A812ALR0_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Gustatory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_463</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000007">
        <property type="protein sequence ID" value="CAE1139791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ALR0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032376072" description="Gustatory receptor" evidence="2">
        <location>
            <begin position="18"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
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        </location>
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            <begin position="199"/>
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        </location>
    </feature>
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            <begin position="229"/>
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        </location>
    </feature>
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            <begin position="253"/>
            <end position="279"/>
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            <begin position="286"/>
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            <begin position="311"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1139791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="363" mass="42115" checksum="439B0637F851856C" modified="2021-09-29" version="1">MILILFLFLSHLSRIFLSSFSPPPSLVSFIHFSFSFSFSNSCLHSFFFFLSISLSIYLSISLFHTFFCLSLISFTYFSFFNLSLSLSISLSLSSLSLIFLFFLVLSLFVSLPLSLSLSLPLSLSLSPSVISLGSFLCFFSFSLSSLSSLSIIFLFLSHSLSLSLSLSHRFLSFSFTHFFIHFFFFTLSLSLISFSNFSFSFFSLFHSLFFFSLSLSLSLSLFSISHFSFFSFSFIFLLFHFSFAHLFQSFFSFFFFSLFYSFFFVYFLSLSLSLSLFFIFQPFFSFSSVLFIFLCFFLSLSLSLFHLFQPFFFFSSVLFIFLCFFLSLSLSLSLISFSHFSFFSSVLFIFVFLSQDISWTHIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AMA2</accession>
    <name>A0A812AMA2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_1800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000051">
        <property type="protein sequence ID" value="CAE1146244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AMA2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="258"/>
        </location>
    </feature>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="565"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="611"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="636"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="671"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1146244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="700" mass="84727" checksum="90C60ABC5A70D502" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ANL7</accession>
    <name>A0A812ANL7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_1829</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000052">
        <property type="protein sequence ID" value="CAE1146379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ANL7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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        <source>
            <dbReference type="EMBL" id="CAE1146379.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
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    </evidence>
    <sequence length="395" mass="46690" checksum="2FE7E8923EC9C8EE" modified="2021-09-29" version="1">MSLSFSLHTHAYTHTYISIYLSIYLSIYLSIYKYIHTLECGCIELLVENRGAIYIYLSIYLSIYLSICSEHESILSIYLSIYLSIYLSIYHNVFSIYLSIYLSIYLSISSCSYISQSVHIYLSIYLSIYLSIYLHRSLNVFYIYLSIYLSIYLSIYLSSSVSQCVHYLSIYLSIYLSIYLSIYLSIYLSKYINKFQYIIIITNNKIILSFFLSFFLSFFLCPTVSFSVSFYTNRLRRIPFLIRDTRISIYLSIYLYFFLFKERIHASRLFFLWNLVHIYLSIYLSIYLSIYLSIYLSISVCSYLPQSVHIYLSIYLSIYLSIYLSIYLSISVCSYLSIYLSLFISIYLSQSVHIYLSHVSNCHENTYTRQESSVTEGSIYLSIYLSIYLSIYLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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    <name>A0A812API3_ACAPH</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <organism evidence="3 4">
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        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000091">
        <property type="protein sequence ID" value="CAE1151260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A812API3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
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            <end position="20"/>
        </location>
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        <source>
            <dbReference type="EMBL" id="CAE1151260.1"/>
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            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
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    <sequence length="1185" mass="138671" checksum="6BD1682807F30DF6" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ASH6</accession>
    <name>A0A812ASH6_ACAPH</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
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            <authorList>
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                <person name="Bekaert M."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
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    <organism evidence="2 3">
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    </evidence>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
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        <name type="common">Pharaoh cuttlefish</name>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000164">
        <property type="protein sequence ID" value="CAE1156906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AT61"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1156906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="254" mass="30339" checksum="7F396C199D573ACB" modified="2021-09-29" version="1">MLLNRIFVRYSVTQDIRIYLKTSTGEGQTEVKTEKKSISIHVESQPNRVCISVPPTDKTTLLLTFNYFLSFSSSFSLNLYVFFFLYSLHFLTWRSNHYLPHLFSPYIFIFFPPHAFFLPLFKNIILSFFVFFLLCNRNSFFSYSHLSLFFRYFLAFSQFLRSFRPKYSFCLSYSSVTLHKKLLRIYLSIYLSIYLSIYLSISKQKFTTRIYLSIYLSIYLSIYLSIYLSNSSFSYLSIYLSIYLSIYLSIYLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AWI8</accession>
    <name>A0A812AWI8_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SPHA_5584</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000183">
        <property type="protein sequence ID" value="CAE1158329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AWI8"/>
    <dbReference type="OrthoDB" id="6022609at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01450">
        <property type="entry name" value="vWFA_subfamily_ECM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050525">
        <property type="entry name" value="ECM_Assembly_Org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020:SF84">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00453">
        <property type="entry name" value="VWFADOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033052606" description="VWFA domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="3">
        <location>
            <begin position="41"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="3">
        <location>
            <begin position="274"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="230"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAE1158329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="654" mass="73700" checksum="9331549DC6A6743E" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AZL0</accession>
    <name>A0A812AZL0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_6715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000219">
        <property type="protein sequence ID" value="CAE1161050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AZL0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1161050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="260" mass="28781" checksum="710605056FD63F5B" modified="2021-09-29" version="1">MRLSLYFSGSLSLSLSGFSPSFSVAVCFSLLNISIPHALSLSLSFALCVCVILLLFDCFFFLNIAISLSLSPLFFCCCLILLSQYHSPLRSLSLSLSLSHFLFLSLFLSTIHFFSICLPRSVLFTHCSLSLSLSNTLFWHFSLPHSLSSSLCIILSVFQFCFSITVFSPVSLAFSTHLYLSSLSLSLSLSLLSLSYSSLCLHYQFIFFAQNIDSLSFSPLHSLSLSLSLSILLITLESLSFPLSNFPSSLIISFFLSDLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B076</accession>
    <name>A0A812B076_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SPHA_8411</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000272">
        <property type="protein sequence ID" value="CAE1165375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023616">
        <property type="entry name" value="Cyt_c_oxase-like_su1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000298">
        <property type="entry name" value="Cyt_c_oxidase-like_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50855">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50253">
        <property type="entry name" value="COX3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="293"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="355"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="389"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="419"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="451"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="479"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="504"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="532"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="565"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="594"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="635"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="661"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="689"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="728"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="763"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="794"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="820"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="846"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="872"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="896"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="925"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="950"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="979"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1005"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1038"/>
            <end position="1060"/>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="279"/>
            <end position="305"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="317"/>
            <end position="341"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="347"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="401"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="446"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="478"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="508"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="533"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="565"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="606"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="648"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="730"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="775"/>
            <end position="796"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="802"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="835"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="867"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="897"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="693"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="693"/>
            <end position="719"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1170860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="936" mass="110337" checksum="A27B54E9CDB2CCE1" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BAD7</accession>
    <name>A0A812BAD7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_13737</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000461">
        <property type="protein sequence ID" value="CAE1175636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BAD7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1175636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="207" mass="24139" checksum="1C9092A032330C3D" modified="2021-09-29" version="1">MSHYPSPRLTDSPVSKCPPCPRDKRLRDTIYLSIYLSICLSHACFINLSIYLSIYLSIYLSIYLSIIFSSLMSNTESSTSLKDSPSQMGHSISVNFQLSPISYSTTFSSFLPSFLPSFPPFLPSFLPSFLPLVIFSASFLFFLYIKFSFFFSIFLLFFLNVKFSFFFRRFFSLFFFLNVNILFLASFFLFLFLSFFLSFFLSFFLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BC14</accession>
    <name>A0A812BC14_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_13961</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000472">
        <property type="protein sequence ID" value="CAE1176044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BC14"/>
    <dbReference type="Proteomes" id="UP000597762">
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
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        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1176044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="196" mass="22926" checksum="ACED38653EB7D2D8" modified="2021-09-29" version="1">MKFTDGHLKQFWASQWETYPILAKKSSRCADVFRGYILDVPLLSPIYLSIYLSIYLSIYLSQQFIYLCSSYNLSIYLSSLYNQSGNLSIYVPHIIYLSIYLSIYLSIYLSSLYNQSGNLSIYVPHMIYLSIYLSIYLSIYLMLTVDSCTSIYVHHIISLSIYVPYVIYLSKELLPWSNDQQTNFVKFCFSGKFIPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BE29</accession>
    <name>A0A812BE29_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ACAD10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SPHA_15095</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Farmed</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000522">
        <property type="protein sequence ID" value="CAE1178269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BE29"/>
    <dbReference type="OrthoDB" id="434771at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000002">
        <property type="entry name" value="Acyl-CoA dehydrogenase fadE12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000018">
        <property type="entry name" value="Acyl-CoA dehydrogenase family member 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF35">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE FAMILY MEMBER 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="9">
        <location>
            <begin position="145"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="8">
        <location>
            <begin position="237"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="7">
        <location>
            <begin position="350"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAE1178269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="505" mass="56355" checksum="7B7F2BB95199CB9B" modified="2021-09-29" version="1">MNLPPITNWHFYIVYTFFRYAAILQGVYKRAISGQGTNPKAEASGKYLTILAEMGLQFMKQEKSSSNLLKSQSPISGTNHLNRRSFSTSAVKSSENYIPFSVKSLSPRVQEMHQRVKELICQSIMPLEGDFIKHIQSDKRWSPFEPLEALKEKAKSEGLWNLFLPLESDAEVKYGSGLTNVEYAFICEEMGRCFFAPEVFNCSAPDTGNMEVLVKYGNEEQKMTWLQPLLDGTIRSCFAMTEPEVACSDATNIQSSIVKDGDHYVINGHKWWTSGALDTRCKLCIFMGKTSLTAARHKQQSLILVPMDTPGVSVIRPLNVYGYDDAPVGHGELTFKDVRVPASNLLLSEGQGFEIVQGRLGPGRIHHCMRLIGMSERALELMIQRVKSRTAFQKLLAEQGTIQADIAMSRLEIEQARLLVLKAAHMMDTVGNKAAAAEIAMIKVVAPNMALRVIDRAIQAYGGAGLHSDLPLANMFAWARVLRLADGPDEVHRQSIAKAEFRKYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BJ82</accession>
    <name>A0A812BJ82_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_18364</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
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            <authorList>
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                <person name="Bekaert M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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    <name>A0A812BJX6_ACAPH</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Acanthosepion pharaonis</name>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
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        <source>
            <strain evidence="2">Farmed</strain>
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    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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    <name>A0A812BN09_ACAPH</name>
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        <submittedName>
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        </submittedName>
    </protein>
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            <authorList>
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        </citation>
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            <strain evidence="2">Farmed</strain>
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    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000872">
        <property type="protein sequence ID" value="CAE1243030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BQY9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1243030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="364" mass="44734" checksum="C0F7B30A00669178" modified="2021-09-29" version="1">MFLLSFLIFLIFFLLFVFFDLFASFSNSPFFLSFFLSFFLSFFLSFFLSFFVFSSHIHSFILSFLRFLSFFFFLSFFLSFFLSFFLSSYIFPFPFFCLSYFASFLRFLLSFLYFHLFFVFSSFFLSFFLSFPSFLFLLLVFPFLSFIVFSSPSFFIFFLSFFLSFFLSFFLSFFLLLVFPFLSFFIFSSPSFFIFFLSFFLSFFFFLFFLFFLSFFIFSSLLFFLSFFLSFFFFLFFLFFISSSFLLLHFYFLSFFLSFFLSFFLSFFLSSLLFFLSFFLSFFLFSSFCFSFSFFLHLFFSFIFYFFPFFLSFFLHLFFSIFYLQSLYRDNFKRRHFNAEPATTLQIQFSDYSGGPPHRYLLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BT78</accession>
    <name>A0A812BT78_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_22350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000825">
        <property type="protein sequence ID" value="CAE1240491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BT78"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033014709" evidence="2">
        <location>
            <begin position="18"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1240491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="300" mass="33721" checksum="58639FB515C480E3" modified="2021-09-29" version="1">MLLLGLLVGSIIVNYSAQPSVHLLVCPCTSKFFALNQIKFLTSQLLSTFSHHKSISSLMVPISHTLPFACSQSPFTCSQYPSLFSLLVLSLPLPVLNILPFSLCLFSVSLYLFSISFPFLFTCSLSHFIIILLFLSFLPFFSLCLSSVSFFSSLFVSPQSLFFFLSFLFLSFLPFSLSFSSVSFPSSHFACFQSLSFLLSFFLPFPLSFSSVSFPSSHFACFQSLSFLLSLLVLSLFSFFSLFLSAVSFLILVTFLYPPLYSLLLRNLPFLSLHIPFLHHLLSLSTSSYYQSLLCHLFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BUS1</accession>
    <name>A0A812BUS1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_23140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000857">
        <property type="protein sequence ID" value="CAE1242121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BUS1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1242121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="289" mass="33962" checksum="F19FC1237EAE9476" modified="2021-09-29" version="1">MFFFLSFFLFSHIICLSRVSFFLSFFFSFFLSFFHTLFFCPMFLFLSFFFFLSLINSSFTHSHIICLSHVFLPFFLFIISYFLSHIICLSHVSLSFFLSFFLSFFLSFFLSFFLSHIICLSHVSLSFFLSFFLSFFLSLKNFYFIHSFLFLNFSLKSIYLSIYLSIYLSIYLSILKVIHSFFFCLLFCLFVSLSLPSFVSYNDTFYFALILSTFLSVCLSVCLSVPYFTRFLFPPLSIPIFLSYILLSYVSPSLLYTSSLSTSLVYSYFCSLPLSLSPLSHTNTHTMCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BYN8</accession>
    <name>A0A812BYN8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_26487</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001013">
        <property type="protein sequence ID" value="CAE1249256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BYN8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1249256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="239" mass="29485" checksum="770D06F09D188CC1" modified="2021-09-29" version="1">MFFIVYSFLLLLSSYLLFFFFLHLHFFFLLFVSFLFFCFFVFFFFFFFFNSLSFLPYCPRLLPFLLCFSFISSSFLPLFFFFFFFFKYISFLPHSFTNYFLSYILLQDSFSSFLYLFFHLHFFFSSFRLFSFLLLLLLQYFVFSPLLSSSSSFPSLFFLHFFFFSSSFNLLLQIYFFPSSFLYKLFPFIYSSPRQFFFLIPIPLFSSSLLYYSFSSPLTYRLFFFFFCNKTIYFPSSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C0B5</accession>
    <name>A0A812C0B5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_27402</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001061">
        <property type="protein sequence ID" value="CAE1251142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C0B5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1251142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="234" mass="27873" checksum="1746E72BC4C6E7B2" modified="2021-09-29" version="1">MSTFFFYSENIYIYLSNYLSIYLKIFLSIYLSIYLSKHFPIYLSIYLSICLYSYLSIYLSIYLDISIYLSKHFPIYLSIYLSACLNLFIYICPPIYLFIYLSKPFHIYLSIYLSIYLSIYLSICLNIFLSIYLSIYLSIYLSIYLSACLNLFIYICPPIYLFICLSKPFHIYLSIYLSIYLSIYLSMYLNIFLSISIYLSIYPSSIYLPASKPFHIYLSIYLSIYLSIYLSKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C1E3</accession>
    <name>A0A812C1E3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_26715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001020">
        <property type="protein sequence ID" value="CAE1249669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C1E3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="293"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1249669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="319" mass="36697" checksum="36FF139995B5476E" modified="2021-09-29" version="1">MHCSKAVCAEHRDNLLCCRWPSNLEKVLFFRLARHTTVYFFISLSVSVLLPESLSAIVGLLVCSSFYMHTNLSHFLSLSLSLSLSLSDLVFFPTLCYWLILGAFVTLYSSKCLYLSIYLYIYLSIYLSIYLSISVNYLSIYLSIYLSIYLSIYLSELSIYLSIYLSIYLSISVNYLSIYLSIYLSIYLSISVNYLSIYLSIYHLSISVNLSIYLSIYLSIYLSIYLSELSIYLSIYLSIYLSIYLSESSIYLSICNFYLSVISIVDFKFIYFFFSLSFFLSSISDLVLSPSPIFYPLSLSLSLSLIWFSLSLFSVSLPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C3U5</accession>
    <name>A0A812C3U5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_31919</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001324">
        <property type="protein sequence ID" value="CAE1259959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C3U5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="290"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="314"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1259959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="368" mass="44429" checksum="9C3EB26280AD9011" modified="2021-09-29" version="1">MFFSLYFSAFSCYLHILFQHFLSLSLLSFYPRDLYFIFSAHFIHLFLTLEYSSHFFVLWSQSSYLVPVLLTFIHFLTIPSSFCFSLSSAFPILRGRISLLICLTYSIFSFHFFLFLFSISFRLSFYLSFFLSFSFLPSFLLSFYYFLPSFLPYFFLSFFFFLSFFLLPSFLPSFLPSFLPSFLPSFLFPFLTFRYSFSFICPSLGLKSIISLFNIFFSIFLPYISFFSMKVIKPFFFPYFLFTFSFFYIFHPFSYFILFFHSFLSSHSVILFPSAFLFSSFFYIQDIFFLLIYFFLLVCLSFATCFLSTSFYNFFFILSFFFPPFSGYLFFTQFFYNYFLLSKCYMLSFFSILFVCLFCLFLYCLVFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C5E0</accession>
    <name>A0A812C5E0_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Actin-modulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SPHA_29856</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Farmed</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Calcium-regulated protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). Can promote the assembly of monomers into filaments (nucleation) as well as sever existing filaments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with actin monomers and filaments.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the villin/gelsolin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001198">
        <property type="protein sequence ID" value="CAE1255874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C5E0"/>
    <dbReference type="OrthoDB" id="6375767at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051693">
        <property type="term" value="P:actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008154">
        <property type="term" value="P:actin polymerization or depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11290">
        <property type="entry name" value="gelsolin_S1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000043">
        <property type="entry name" value="macrophage-capping protein-like isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007122">
        <property type="entry name" value="Villin/Gelsolin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11977:SF130">
        <property type="entry name" value="SEVERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11977">
        <property type="entry name" value="VILLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00597">
        <property type="entry name" value="GELSOLIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00262">
        <property type="entry name" value="GEL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0117">Actin capping</keyword>
    <keyword evidence="7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Gelsolin-like" evidence="13">
        <location>
            <begin position="64"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="13">
        <location>
            <begin position="187"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="13">
        <location>
            <begin position="299"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="256"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00056258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00063765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00083856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAE1255874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="374" mass="42808" checksum="EFCFB54560B211CC" modified="2021-09-29" version="1">MSGLIKAKKYNWKDSNMELVGSDVDRAVKKEAAQKEPMWQGTGESPGLKVWRIEKFIVKEWPKEEYGRFYDGDSYIILNSYLKNDKLYHDIHFWIGKYSTQDEYATAAYKTVELDTYLDDVPVQHRETQGYESKLFLSYFKRYEIFKGGVATGFKHVTPEQYKPRLLLFHGTGKNITVKQIAISKGLSSTDVFLLDMGVQIVQWNGRDSNMFERNKASMYLQQIKGERSGKSSSEVIDEDEDDGKVIDSYMKKCENDDDDDDDDDDGIDDSKMDIPRTKKLFKMSDASGTIDIELVAEAEGKLSKADLNSVDVFIVDTGTECFVWIGRRASHNEKQNCFTYAHNYLQTTSHPLIPISCFGEGNEDANFHQLFTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CBU5</accession>
    <name>A0A812CBU5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAGS</fullName>
            <ecNumber evidence="3">2.3.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_30589</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.1" evidence="3"/>
    <dbReference type="EMBL" id="CAHIKZ030001230">
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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</entry>
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</entry>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="5" xmlns="https://uniprot.org/uniprot">
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            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001428">
        <property type="protein sequence ID" value="CAE1263825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CDK4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1263825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="925" mass="106201" checksum="B38D9195E8E209A2" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CJC0</accession>
    <name>A0A812CJC0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LGMN</fullName>
            <ecNumber evidence="3">3.4.22.34</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_35201</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.34" evidence="3"/>
    <dbReference type="EMBL" id="CAHIKZ030001512">
        <property type="protein sequence ID" value="CAE1266513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CJC0"/>
    <dbReference type="OrthoDB" id="1937694at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032701422" evidence="2">
        <location>
            <begin position="22"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="433"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="472"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="533"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="660"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="707"/>
            <end position="726"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1266513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="835" mass="96115" checksum="705D6841106EED8F" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CKS3</accession>
    <name>A0A812CKS3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CSL4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SPHA_40919</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001946">
        <property type="protein sequence ID" value="CAE1277842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CKS3"/>
    <dbReference type="OrthoDB" id="440760at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05791">
        <property type="entry name" value="S1_CSL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000198">
        <property type="entry name" value="Exosome complex component CSL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039771">
        <property type="entry name" value="Csl4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019495">
        <property type="entry name" value="EXOSC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025721">
        <property type="entry name" value="Exosome_cplx_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12686">
        <property type="entry name" value="3'-5' EXORIBONUCLEASE CSL4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12686:SF8">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT CSL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14382">
        <property type="entry name" value="ECR1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10447">
        <property type="entry name" value="EXOSC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110324">
        <property type="entry name" value="Ribosomal L27 protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0271">Exosome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="4">
        <location>
            <begin position="67"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAE1277842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="198" mass="22065" checksum="385020299AFC4109" modified="2021-09-29" version="1">MAKSVVCIPGQKLCRLSEENCNGNGTYVRNGYVYSSLAGYLCTQTVNDKVLVEVRSAKDQNIVPSVGAIVTAKITNVNPRFCKCLIQNVGQTQLREPFRGMIRKEDVRATEKDKVEMYNCFRPGDIIVAKVLSLGDAHSYILTTAENELGVVLATSDAGYTMVPISWCEMQCPHSLMKEQRKVAKVQQQYIEYADNKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CQ96</accession>
    <name>A0A812CQ96_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_39008</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001798">
        <property type="protein sequence ID" value="CAE1274669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CQ96"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1274669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="236" mass="28001" checksum="167D1D46B1EEEA97" modified="2021-09-29" version="1">MLGNIAIIFRCQICIESICDIFRSRLESINFFLFRIDYFFIIIFFVLNICYLLRVHVWGGERKRERKGQEFRQLYNFTCLFFLSFSTYTDLTEGTLSLSLSLSLSVSLFYVLSPYVYLPFPLNVPMIHHFTLLLFPLSVAVILYFMRLSFPVYALIIHSLRICYSHLTRLLFPTLHAHYSHFLRLLVFIYMLIIFHFTRLLFSPYAPTVPILCSYYSHFTSLLFPLYVPFISTLCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CQF0</accession>
    <name>A0A812CQF0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_41524</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002000">
        <property type="protein sequence ID" value="CAE1278937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CQF0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="324"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="381"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1278937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="414" mass="47587" checksum="35DFD8509A670935" modified="2021-09-29" version="1">MLPVSVSLCQIFPTNVFFLMLIFATTVSVFLPVSFNLSLFYAIFILPVSVSFLLPVSQVSVSFCLIFLTTSVCLFLCNFLYQFFILPVSVSFLILIFLCTSVCLFLCNFHSSTVSQSLFCLSLFVLIFILPVSVSFYAIFHILPVFSFYQFHTTSVCLFYADFHTTSVCLFLIFSFTSVCLFLFFILPVGPSLFNTDFLPCHQCLSLFYAQFFHVCPFSQSSFTTLFSFSYCSVLVLSLLCNFSYYQCLSLFMPQFSLYYQCLSLFNTIFILPVSISFYLLFHTTSVSLFLYTDFPYYHVCLFYAIFILPVSQSLLCNFLTTSVVFFVLIFLTTSVCLFFIADFSPYYQCLSLLLRFHTTSVSFFNTDFHSTSCLSLLCSFHTTSVCLFFMLIFIPSVCLFYAIFMHQCLSLFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CQG3</accession>
    <name>A0A812CQG3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_39779</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001868">
        <property type="protein sequence ID" value="CAE1276050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CQG3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1276050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="250" mass="29993" checksum="7D15BE24EBA4FFD1" modified="2021-09-29" version="1">MFPSVLSTSLLSFFLSFFLFFSFFQFPSSNVFPLFSLPLLHFFLSIFLSFFLSFFQFPFYFNSFPSVLSTSFTTFFFSFFLSFLSFFLSFFPISLTGNVFPLFSLPFFSSFFSFFLFSFFLSFNFLTGNVSSVLSTSFYFFSFLSFYLSFFLFFSFFQFPSLVMFPSVLSFYLSFTLLSFFLSFFLFFLSFFLSFFQFPFILSFLSFNFSLVMFFLCSLSSFFFFLSFFFSFSFFLSFFLSFFSFNFPHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CS54</accession>
    <name>A0A812CS54_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_39020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001799">
        <property type="protein sequence ID" value="CAE1274694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CS54"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1274694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="171" mass="19385" checksum="C8FC9B79C98CA467" modified="2021-09-29" version="1">MIIHPPSFTDNSRFLILSSSAHLISSTAHFYHIYRPPTLIIDPSLFSHRPLSLLLSLSAFPISLVIHPPSFSHLPPDLLILSYRYPLYRSPINNLIPNLSSSFSFSLSFLSSILPSFLLSFILFYLSSFCFLHSFFPTLLPSFFSVSSLPSFLPSFLLSFIHSYFFSVILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CUJ4</accession>
    <name>A0A812CUJ4_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Max-like protein X</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Max-like bHLHZip protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Protein BigMax</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Transcription factor-like protein 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">SPHA_42267</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">Farmed</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MAD1, MAD4, MNT, WBSCR14 and MLXIP which recognizes the core sequence 5'-CACGTG-3'. The TCFL4-MAD1, TCFL4-MAD4, TCFL4-WBSCR14 complexes are transcriptional repressors. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAD1, MAD4, MNT, WBSCR14 and MLXIP. Can also bind DNA as a homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002057">
        <property type="protein sequence ID" value="CAE1280302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CUJ4"/>
    <dbReference type="OrthoDB" id="5778525at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140297">
        <property type="term" value="F:DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19687">
        <property type="entry name" value="bHLHzip_Mlx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000037">
        <property type="entry name" value="max-like protein X isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052207">
        <property type="entry name" value="Max-like/E-box_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX ZIP TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741:SF25">
        <property type="entry name" value="MAX-LIKE PROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="18">
        <location>
            <begin position="75"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="44"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="72"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00053727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00065416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00071251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00076041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00079081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00082933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CAE1280302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="246" mass="27461" checksum="84B9659F1272D904" modified="2021-09-29" version="1">MMSGSPFGDSSLDQSNMMDSDLKIETSPTGDPHFTFIRANSTGSLAAGCASSASSAHNTDDEDSDNRTMMSYKDRRREAHTQAEQKRRDAIKKGYDELQMIVPKCQQPDSLGSQKLSKATVLQKSIDYIGYLVDQKSKQEVALDNLRKEVMALKIMKANYEHIVKTHQNTPQAGQNQVSDEVKFQVFKQVMDSLFTSFVSTVSVANFAELSGCVFSWLEEYCKPKNLKELVVGVLQQISNQPNLNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CWJ8</accession>
    <name>A0A812CWJ8_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7041 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_42268</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002057">
        <property type="protein sequence ID" value="CAE1280326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CWJ8"/>
    <dbReference type="OrthoDB" id="6159822at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055469">
        <property type="entry name" value="DUF7041"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327">
        <property type="entry name" value="ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327:SF3">
        <property type="entry name" value="RNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23055">
        <property type="entry name" value="DUF7041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7041" evidence="2">
        <location>
            <begin position="9"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="135"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1280326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="228" mass="25181" checksum="4BC5DF06E6A4D3FC" modified="2021-09-29" version="1">MSAAVAPFPPFHEGNIKNWFLQMEAIFTVRRITDQKTKFGHVVAVLPPAIVDEVSDFLEAVPEDSLPTSSLYEKPTRQKYHGRLYIKKLVAGPSPPTTITQILAPMSENTSIDQLADAADRIFSQLDNQTTPVHSAEATGDHRSLEKTVEELQRQVKDLTLALKSRGRSRFPSAGASEVDHARPAEIRMPLLLCVTTTEDLGLKLITASSRVLILRSRKTKPPASESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CWR9</accession>
    <name>A0A812CWR9_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb/SANT-like DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_42364</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002068">
        <property type="protein sequence ID" value="CAE1280499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CWR9"/>
    <dbReference type="OrthoDB" id="6135369at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028002">
        <property type="entry name" value="Myb_DNA-bind_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21411">
        <property type="entry name" value="APONTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21411:SF0">
        <property type="entry name" value="REGULATORY PROTEIN ZESTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13873">
        <property type="entry name" value="Myb_DNA-bind_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb/SANT-like DNA-binding" evidence="2">
        <location>
            <begin position="5"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1280499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="480" mass="52466" checksum="3D9F66985056DD3F" modified="2021-09-29" version="1">MSTRRSANFTHHEKQVLLSLMQEYRHIVEDRHTDGVTVREKNSAWITLTNKYNAENDVSARSVKQLRQCWKNLKSRSRVDFLRVPGEAGSNDSGTLTLVPPGGTSSSSNIGSGGSGSALTLLTVGGMSNSASTNEVSGSSPSNNTSSIDNAGTIILNNILTNNSNNINYNNISNNINSIRSTNGISTGDLSSHSGSPGLTDFSQSLPPTTAVANRQRPEPKTSSSNKKRKKKTPNNRKNIGPTATVSVEDGIDEEVTEVSRTRRKSRPSLVHLDYDKNGVLEDEENVAEVERPRRKIRPSVMHLDYDVSTTVDDDDDDDDDDVGAAVVADEDVSERLQVSVGYPHDSAVVVSQQGHSQEPEDVYPTDTLAVVSVSGSADRIHFNNHASSPDPDDIHHHQQSHEVNLHSQPQTDYRLSQHNPTSPHHLQIQPSAFQPTPLTANSNHLEDGLNHATGSGPDIKVFDSIRGMINYEYFFFFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CX69</accession>
    <name>A0A812CX69_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">V-type proton ATPase subunit a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SPHA_46387</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Farmed</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the V-ATPase 116 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002446">
        <property type="protein sequence ID" value="CAE1287140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CX69"/>
    <dbReference type="OrthoDB" id="10264220at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000220">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002490">
        <property type="entry name" value="V-ATPase_116kDa_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026028">
        <property type="entry name" value="V-type_ATPase_116kDa_su_euka"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629:SF63">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629">
        <property type="entry name" value="VACUOLAR PROTON ATPASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01496">
        <property type="entry name" value="V_ATPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001293">
        <property type="entry name" value="ATP6V0A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="387"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="432"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="529"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="560"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="589"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="626"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="85"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAE1287140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="758" mass="86248" checksum="9B3AD50A873D9D31" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CXF0</accession>
    <name>A0A812CXF0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_42213</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002051">
        <property type="protein sequence ID" value="CAE1280234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CXF0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1280234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="298" mass="34518" checksum="1B2E053D36A077BD" modified="2021-09-29" version="1">MHLSVCSYLSIYLSIYLSVYLSKLVQTCISACSSLSLSLSLSLSLSIYLSLFLSIYLSIYLSGARLSTSFGPHQSKVYLSKVVHSYFSLVISIYLSIYLSIYLSIYLSISVCSYLFYFFVSIYLSIYLSIYLSIYLSKLGHIYLSIYLSIYLSKISVVKFNKRIYLFHSTHFLSIYLSIYLSIYLSILVCSDLSIYLSIYLSIYLSIYLPFFDLIDFSFTDLSIYLSIYLSIYLSIYLSIYLNDSACSFFLSFCSYLSIFCFYLSMFVQIYLCLSVQIYLSIYLSIYLSIYLSIYLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CY97</accession>
    <name>A0A812CY97_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_41920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002024">
        <property type="protein sequence ID" value="CAE1279754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CY97"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1279754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="292" mass="33855" checksum="EFB748579CFEF242" modified="2021-09-29" version="1">MGLVSSLLSFKSSFVIKHFFFIFPFHFFFFFVWHTLFALFVLSHRPSSVFFFVIYLFNLSLPLVLLLSAFFHFIFPIHLSPSFSFFISLSSLLSIIRFFPLFAYLLLLLFLFTLSLSLSLSLSLSFSSVSCFAFSIFCSLHLTSYLPPFFSFLPLSLLFLHFIISSSPSFPTFSFLSVPLSFFLSFPPLFFDSSLSGSHFYTLSFLLSLYFFCILFYLLRLSLLDLTPRNLFFFSVFSSFFILYLGQFSCRMFLSSSDSSIYLSIYLSICSLPIYLFQSICYLFQSVHCVAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CZC1</accession>
    <name>A0A812CZC1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_47268</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002556">
        <property type="protein sequence ID" value="CAE1288846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CZC1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1288846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="258" mass="28501" checksum="12B3B618403EB6CA" modified="2021-09-29" version="1">MNSSVRRRLPNVCKNGVADKIWLKTVKEDVEPFCWEFAIGTVIWLALYVSTASDHRVWSAFVQDAANSYNGAGLNEPGRVPQEIVSLSPIFFFILFSSLFFRCFSSSSLSSCSCFCSSLSAISSLSSFSFLLLLLLLPFLLHFSPFYLSSSLSSSLSSISFSSPFPLSSSSSSSSLSATSSLSSISFLSSFSFLLFPFFFPFFFFFFFFLFFFLFFSFLPFFFIFFFFLSSISFSSPSSLSSSSSSSSSSSSSSSSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D2B1</accession>
    <name>A0A812D2B1_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_46159</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002424">
        <property type="protein sequence ID" value="CAE1286733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D2B1"/>
    <dbReference type="OrthoDB" id="10064731at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1286733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="254" mass="28830" checksum="91E0B3EFDB4E18A0" modified="2021-09-29" version="1">MKVIGTPPPTIIVCSEPFLFLSFHRRCYPVSNDPTLSMLRYVTALERTSIQSFFGRPPHLFQPSSQQLRPTETPDKLKFRKQSFRPNAQGWNCPSIGQPPPTRAPLHLAAKPGVNILSPSLSLISLATHSPTFPSHIPSSFFLFSSAALRTVSFLKDRYPVPHLQDFTSGLQDAKIFSKIDLKKAYQVWNEHPFSFFGRLAFCRQSNGHVTHRIPAKKYPQVRDDLRASSREDVFLHLSLSLSPLSFFFFPSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D3D4</accession>
    <name>A0A812D3D4_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CHAT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_46412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002446">
        <property type="protein sequence ID" value="CAE1287113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D3D4"/>
    <dbReference type="OrthoDB" id="5951504at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024983">
        <property type="entry name" value="CHAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10098">
        <property type="entry name" value="RAPSYN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10098:SF108">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12770">
        <property type="entry name" value="CHAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHAT" evidence="1">
        <location>
            <begin position="296"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1287113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="948" mass="107563" checksum="71A3D95760AE2E2A" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D986</accession>
    <name>A0A812D986_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_51721</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003154">
        <property type="protein sequence ID" value="CAE1296936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D986"/>
    <dbReference type="OrthoDB" id="2403182at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1296936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="260" mass="28596" checksum="672EDD2915C4DB2D" modified="2021-09-29" version="1">MKPQRGKTPKKKYGFSGVTVTEPVEVYCRIKPINDPDKICLKNIGENQVQLIQPLHSICDKICPSTCYKICPSTCYKICPSTCYKICPSTCYKICPSTLALAFGHPPARFHDAIHMRMRWSKVALKSGLFIAMEALGGTFSVAKFTSPEPLIWTPPSFAITSTPSRRSSPGKVWCTINTSTVTGRMFLIFNSIVSTPRLVRVFPSAVTICASLALHERYADLHLRPSTSSLITGSASMLYLPGEETGAGVFFPDSFSRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DC00</accession>
    <name>A0A812DC00_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_49066</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002777">
        <property type="protein sequence ID" value="CAE1292028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DC00"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1292028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="259" mass="30958" checksum="247E7AC9A50FFC59" modified="2021-09-29" version="1">MHLLKPLHNNFLSFEGATSHDILTGKDVLYYHCIIILDTSAFLSLVRSFTDGVMFILFFTVLFLFILPLPVLFSFFLSLIDFFHCLHFLLSFFLSFFLSFFLSFFLSLHHPFSSFHYLLYFLSFFFLLSFTYCFLLFLSLPPFFLYLLIDFFTFSLLSFFFHCLLYSLPSLISFTACFLSFLFHFFLSFFLSFFLSFFLSFFLSLVCHSLFHFFLSFISLFLFLSFFLSFLENQHPKYSLPEIECQIQMATEKKYQFQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DCZ3</accession>
    <name>A0A812DCZ3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_50658</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002999">
        <property type="protein sequence ID" value="CAE1294938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DCZ3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134:SF22">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134">
        <property type="entry name" value="OS08G0543275 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="355"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="395"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="425"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="461"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="493"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="524"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="552"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="585"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="615"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="649"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="671"/>
            <end position="697"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1294938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="732" mass="85102" checksum="123108E5FC2A8ED3" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DD86</accession>
    <name>A0A812DD86_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_50696</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003005">
        <property type="protein sequence ID" value="CAE1295012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DD86"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="131"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1295012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="166" mass="19623" checksum="66908E4C2D40CA1B" modified="2021-09-29" version="1">MVTPPTPEDKQKNDNIFMKEERSQSDSAVGQKVVGHASSEQDENPKDWLRLNTYDAESRRGSDCTGLKRHKTLISPRRVVSLKQELPKEKHYEKSIKLSFFLSFFLSFFPIDTSTFLSFFTFSIFTFFSFFLILFSLFFFFFFLFFLYFPCIVFLSFDIFLSFLSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DD89</accession>
    <name>A0A812DD89_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAS1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_50240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002935">
        <property type="protein sequence ID" value="CAE1294173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DD89"/>
    <dbReference type="OrthoDB" id="286301at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050839">
        <property type="term" value="F:cell adhesion molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050904">
        <property type="entry name" value="Adhesion/Biosynth-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900:SF124">
        <property type="entry name" value="FI05614P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900">
        <property type="entry name" value="PERIOSTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032304972" description="FAS1 domain-containing protein" evidence="1">
        <location>
            <begin position="27"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="2">
        <location>
            <begin position="35"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="2">
        <location>
            <begin position="188"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1294173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="341" mass="39067" checksum="664F90AEADAFDC9C" modified="2021-09-29" version="1">MADDGSFSRSSTICFFLILMLSEVIGIRTGDHVFTRRNLLQLLNDQGLTKFLDLITKAEIQGTFTSTEEMTVFAFNNTAFDILPSERKTAIRKKNREETENFVKFHTVYKERILTENMLDNSRLKSNGLNQNILFVNKKRLQIGVDYDKTEQIFINGARIVKRDIYATNGILQIIDRVLEITSNKMAVPYLDHPDDPRVKGKQFYDLVRHSEARDELKNEAQLTLFVPTDKAMERINKEKLDQQRQNPQALKEIILKHRISNQVIFTSTVEFGTQWTPNSNIPILNKNTYEQVFVTSGDTTAQIVLGNVTVGNGVIHMIDNLLGFTYNNVMEQIIGDPQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DFP4</accession>
    <name>A0A812DFP4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_55294</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003667">
        <property type="protein sequence ID" value="CAE1302910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DFP4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1302910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="213" mass="24806" checksum="C1025EC064FBC734" modified="2021-09-29" version="1">MLRPHFIRAINYSVFLHLPTKCRSPPGPHPSKPRANGIPESKENVTLWLTGETKSIYLSIYLSIYLSIYLSIARTHTHTHTYTFHFITIPSILYLAIYLSKNVIYLFWSLHFLSSFLPSFLSIYLSIYLSIYLLTIDFNLSIYLSIYLSIYLSICLSILFILIYLSIYLSIYLSIYLSIYLSHSNCLSIYLYILVCSYLSIYLSIYLSIYLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DG16</accession>
    <name>A0A812DG16_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_52896</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003326">
        <property type="protein sequence ID" value="CAE1298880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DG16"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1298880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="224" mass="27645" checksum="308837A84CFFCF5D" modified="2021-09-29" version="1">MLAELVYDGPEITREAELWQRIQDAKNRLLETRRDVIINILPKSIYLAYYYYFFSLSLSLSLSLFVEWFFLCFFFFTPFLIPFHLLFFFYFVYHYFSFILYSFFLSFILCLIHFLSFYILYLSSILLNFSFFILFHSFSFILYSSDINTHCLFFQSFITFSSFILCFIHFLEFYILYLSALLLNFFFLYFVFHSFSFLLYPVTFSLFIKLFYFFYPVFHFFSFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DGH3</accession>
    <name>A0A812DGH3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_56386</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003722">
        <property type="protein sequence ID" value="CAE1303558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DGH3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1303558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="293" mass="35513" checksum="EFE489701E7E22C6" modified="2021-09-29" version="1">MLCSKKRISGGDHTVALSSLHRRQDVDASALLKSLIRIGNIKQIKTYFSLVFISYLIFFFILFSFSFFLFFKTIYFLFFFLSNIYFKLLSTFLSFFLSFFLVSSILLNDFFLSFFLSIIILYSPFFLSFFLSFFLSLLMYLFIHSFFRSFKRLDFFLSFFLSFFLSFFLSFFLVSSILLNNAFSFFLSFFLSFFFSLLMHLFIYSFFRSFKQLDFLSFFLSVFLSFFLSFFLLMDLFIYSFFRSFKQLDFSSFFLLSSFSFFLSFFLFLTRFSFFLSIFLSFLSFFLLFHPYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DGH9</accession>
    <name>A0A812DGH9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_54884</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003625">
        <property type="protein sequence ID" value="CAE1302309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DGH9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032597482" evidence="2">
        <location>
            <begin position="19"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="282"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1302309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="358" mass="41400" checksum="C8E294E18ADF3EED" modified="2021-09-29" version="1">MSLFFFLVLIAFLSLSDFCCLVATISGAQGTHSPYNLHIDSTCLINHGGHYSFQHYYLILAEAFFFFFFHLCIKVCFSSLSLTFFSLSLSLLVTHFLLFHSSTSLSFSLYCSLSFSVPLISSFFFFSFSSSSLPFFLYLHFSLSHFFFISISLLSYFIFSFSFSLLLLSFFFSLFFSLSLSLSNFSFLFISITPIHSLLNLFFNFPFSLNYLFLTLSPFLFFSLSLSISLFLTLSPCLFFSPSLHFSFSHPLSMSLFLTLSPFLFFSPSLHVSFSHSLSMSLFLTLSPFLFFSLSLHFSFSYSFQFLFVSFLSICFISLFLSRASATFSLPLFLFFFFYLNDEYLKSWFRLVMASKRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DK49</accession>
    <name>A0A812DK49_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_57918</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003920">
        <property type="protein sequence ID" value="CAE1305414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DK49"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1305414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="238" mass="28817" checksum="56D396A8F39BBE11" modified="2021-09-29" version="1">MSFHIYLCISVYSYLSIYLLFSVASYLSICPVNDSDFYLLFLFFLAFFFILNSSFHPYSHKLHFSRIFFLSSMFLPFFFSCCPFFNIYFFLHQFLTIPVSSDLSFFLLLFFKLFFLSTIFSYILFLSSFFYIFLNFSLFFLLLLFVSFSLIRHFFILFLSIPLFLTIPVSFLFSYFSFFPFFSTFSSFLFFIFLFHSLVHFLFIFLRFSSLLFLPFSFLFFLLFILHCLFISAFLFII</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DKC0</accession>
    <name>A0A812DKC0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_55253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003660">
        <property type="protein sequence ID" value="CAE1302808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10692170at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="453"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="755"/>
            <end position="2078"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="431"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="454"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="501"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="564"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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        </location>
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        <location>
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        <location>
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        <location>
            <begin position="2061"/>
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        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1302808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="2078" mass="216838" checksum="BC8DFACF7336F347" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DKH2</accession>
    <name>A0A812DKH2_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Small ribosomal subunit protein uS17</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">40S ribosomal protein S11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SPHA_54616</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
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    <reference evidence="8" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Farmed</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003558">
        <property type="protein sequence ID" value="CAE1301760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
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    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
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        <location>
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    </feature>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF16205"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="157" mass="18184" checksum="0204BAA967D843D4" modified="2021-09-29" version="1">MADQTERSFQKQPTVFLNRKEPLKAIKKQKKSLRYVRNVGLGFKTPKEAIEGTYIDKKCPFTGNVSIRGRLLTGTVLKMKMTRTIVVRRDYLHYVKKYNRFEKRHKNMSVHMSPCFRDVTIGDVVTMGECRPLSKTVRFNVLKVSKGSSGKKSFSKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DMB9</accession>
    <name>A0A812DMB9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_55484</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003702">
        <property type="protein sequence ID" value="CAE1303334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DMB9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1303334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="184" mass="21270" checksum="F039E539CD9362E2" modified="2021-09-29" version="1">MQSIIYIGHLWGTPDAVYYLHYFSGTLMQSIIYIGHLSGTPMQSVTSREHRMQSIIYIGHLNTGCSLLFTLEHLMQSIIYIGHLSGTPDAVYYLHCSHRMQSIIEHRMQSIIYIGHPREHLMQSIIYIGHLSGTPDAVYYLHWSPLRNTRCSLLFTHPDAVYYLHCSPSSDAVYYLHWSPLRNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DMJ5</accession>
    <name>A0A812DMJ5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_57763</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003908">
        <property type="protein sequence ID" value="CAE1305320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DMJ5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="148"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="220"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="395"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="420"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="447"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="477"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="515"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="539"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="570"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1305320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="594" mass="72307" checksum="E843D26EFFE93E03" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DNM7</accession>
    <name>A0A812DNM7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_55516</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003702">
        <property type="protein sequence ID" value="CAE1303302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DNM7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032944390" evidence="2">
        <location>
            <begin position="25"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1303302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="202" mass="23312" checksum="41CCBA4D257B11F8" modified="2021-09-29" version="1">MSSFIFFYFSSILTCLPFSTTTSSSSVFFCPSPTLSLIPLNFSSLPLLSRHLIDSQKWETTHISNFHKIYFCVICLLPSCLSLKVFGIYSLYFSTPFSFISSFFSVPYIFFPIAVLFSCSLVIFNLPSFSCRFIDIFVVCLIFRPHFRLFSLSFSFYTFFFLSFPPLDHFSIRLNIPFFPYLSTTTFLSLSLSLFLSLSLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DP06</accession>
    <name>A0A812DP06_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_57823</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003916">
        <property type="protein sequence ID" value="CAE1305370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DP06"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1305370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="262" mass="30654" checksum="856245250E4DF762" modified="2021-09-29" version="1">MFYFDPHCIFQNCDLVAIKLVSIYLSIYLSIYLSISVCSSIYLSIYLSMSSISYLSIYLSIIIIYIIYYHLSIISVCSSIYLSIYLSIYLSIYLSVVISYQLSVPFSSYLSIYLSIYLSIYLLSFHISYQSHSLRIYLSIYLSIYLSIYLSICCHFISVISPILFVSIYLSIYLSIYLSICCHFISFISPIRIYLRIYLSIYLSIYLSIYLSVVISYHLSVPFSRIYLSIYLSIYLLSFLSFIYSISIYLSIYLFIYLSITD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DP85</accession>
    <name>A0A812DP85_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_59644</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004126">
        <property type="protein sequence ID" value="CAE1307611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DP85"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1307611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="223" mass="26140" checksum="FCE526E7D45B7DF5" modified="2021-09-29" version="1">MYVVNRFIIVYFLSVIIFLSLSFFLSFSLSLPFFLSFFFPYLSIYLSIYLSIYLVHCFQYLNLFLSLYVEQFLSIYLSIYLSIYLSIYLSIYLIRFSSCLYLSLPLLSLSPFFSLFTSFSFVLLHSLSHPLYLSMSFTFVSRPVHIYLSIYLSIYLSLINIYLSILYLSLFLSFSLSLSFLSFSLFLSTSFSPSHPISRSLSIHRLPISQGFQIEKPRRLDKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DPW9</accession>
    <name>A0A812DPW9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_58006</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003940">
        <property type="protein sequence ID" value="CAE1305619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DPW9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1305619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="227" mass="27045" checksum="6BA89EB07215322D" modified="2021-09-29" version="1">MRGRERICEALKLLSVLLCLFVGLFLSFFLSFFLSFFLSFFLNLILPSFFLSFFLSFFLNLMLPPILLSLFSCFPPFFLSCFCPSFFLSFFLSFFLSFFLSFLISCFRFSFFLSLVLHAFFFLSFSFFFNFSFVLSFFYLMLPPVFCSFFCLNLFCLLSFFLSFFLSFFLSFFLSFFNTCFSPSSLNPCFSSLHIFISCICSYFFLFFLSFFLSFFLSFFLSFFLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DTH1</accession>
    <name>A0A812DTH1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_60055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004156">
        <property type="protein sequence ID" value="CAE1308109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DTH1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="301"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="331"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1308109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="441" mass="50818" checksum="6680C902A9788A40" modified="2021-09-29" version="1">MTKANTDYLSIYLSIYLSIYLSLYIYLRLFTSSIHLSISIYLSIYLSLSIYIHSSIYPSIYLSISVCSYHSSIYPSIHPSHLFISIYLIHPSIYPSIHPSIYPSQSVHIYLSQTLSIHPSIYPSIYLSIYLSISVCSASIYLSIHLSIYLFIYLSQSVHIIYLSIYPSIYLSIYLSLFHISICQIYLRHLIHPSIYLSIHLSIYLSQSVHIIIYLSIYPSIYLSIYLSISVCSSIHLSSSIIQYLSHSFIYLSIYLSIHLSIYLSIYLSLFTSIYLSIHLSIHLSISVCSYLSISDSSASIYLSIYLSIYLSIYLSIYLSLFISISDSSSIYLSIYLSIYLSIYLSIYLSQSVHIYLRLLSVYLSIYLSIYLSIYLSIYLSIYLHLSVHICLAFYLFYLRLFCLCKTSVLNHIYLCLYDTYLTPLSFSLSHSLSLSLSLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DUP7</accession>
    <name>A0A812DUP7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_60685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004230">
        <property type="protein sequence ID" value="CAE1308864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DUP7"/>
    <dbReference type="OrthoDB" id="10058156at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1308864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="324" mass="38615" checksum="DC6ECB49316E5A0B" modified="2021-09-29" version="1">MSLVNSAFPYSEESRGKLLLPLFKPQNIISRSHDNRKIQNRKFKYTPKGHKNHEFGISFYLSFFLSFFLSFFLSFFLSFFLSFYLFIFLSLFFLSLFLSIFLSIYLSFSLSLFLSYFLLFFLSFFLSFFLSFFLSFFQSLFLSFYRPFSPFFFLSFFFLTIFFLSFFLSIHLSTFLSLSFFLSFFLSFFLSFFFFHYFYPFFFLSFFLSFFFFLSFFLLNKFYHPSLSLSLSLSLSLCFHSISILRDTGIEHTVKGCIQCMKAQKNQPRIVNSYGTYPERSWKFAGPINGLICLAVVDAYSKWPEMARDATDKYSFHCNPQTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DUY8</accession>
    <name>A0A812DUY8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_60337</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004191">
        <property type="protein sequence ID" value="CAE1308439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DUY8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1308439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="253" mass="31326" checksum="FB960610A9BC9484" modified="2021-09-29" version="1">MFHYIFHFFITFLSFNFSFIITSFITFFISSFFHSIFHLSLHLSLHFSFLHYISFIQFFIYHYIFHYIFHFFITFLSFHFSFIITFLSLFFISSFHLSFVTFLFYHYIFSLFFISSLHFSFHFSFIITFLSLYFFISSLHLSFVTFFNSSLHFYYIFIYLITFFISSFYLSFLHCISFINIFQFLITSFFQYIFHFFIPLLSFNTSSIFSLHYFLSLHLSFFFFSLYMSFTFFLIFDLYNIFSVFLSFFFTIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DWI8</accession>
    <name>A0A812DWI8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_63508</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004549">
        <property type="protein sequence ID" value="CAE1312214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DWI8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032556954" evidence="2">
        <location>
            <begin position="22"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1312214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="288" mass="31672" checksum="4E92572869C8D554" modified="2021-09-29" version="1">MSMATFACFTLFFLCLSQSHSFFSAPSSTLRIYTPFTCSSLYSSMLLLQLPPLCIFLPLCFPQPIILFHSFILYPSLTNLSFPLSLSFSSIGLLSSSSLSLSLLPCYALSSSTLCSISLSSSLLCSPTLLFLAMLSHSPLPCCVDSHSPLPHCVLTHSPFPFYALSPLPRYVLSHSPPPHYVLSHSPPPHYVLSHSPLPCCILSHSPLPCCILSHSPLPRCILSHSPLPRCILSHSPLPHCILSLSLLFLAMFTLLFLAMFSHSLFSSSLCFLLCFLFLSCYAFSSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DY28</accession>
    <name>A0A812DY28_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="14">PCDHGA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SPHA_62433</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004467">
        <property type="protein sequence ID" value="CAE1310926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6252479at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000004">
        <property type="entry name" value="Protocadherin 1 gamma 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050174">
        <property type="entry name" value="Protocadherin/Cadherin-CA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028:SF146">
        <property type="entry name" value="CADHERIN 96CB, ISOFORM D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028">
        <property type="entry name" value="CADHERIN-87A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 11" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="16"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="569"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="745"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="13">
        <location>
            <begin position="355"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="13">
        <location>
            <begin position="469"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="13">
        <location>
            <begin position="972"/>
            <end position="1058"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAE1310926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1304" mass="144471" checksum="A05D4735E9A5C2B6" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DY84</accession>
    <name>A0A812DY84_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_64689</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004661">
        <property type="protein sequence ID" value="CAE1313603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DY84"/>
    <dbReference type="OrthoDB" id="6144783at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492:SF57">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1313603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="347" mass="39202" checksum="0D6382F05E9DA360" modified="2021-09-29" version="1">MVPASRITITPAVTTATANSHGITGIDGYPLYRRRSPAEGGFTAAVKANQVDNRWVVPYCPLLSKAFNAHINVEYCHSVRFINFPIHERFPAIVHLAVHLENDELRYFSADRAMDVAARNKDTTLPAFFKLCRQDEFARTLMYPDVPSYYVWTKKNTWARRKCRANVEGYPGVKKDATLGRVFTIPPSRQECFYLLLLLHEVSGPTSYNNLQTVNGVLCDTFREACLRLVILEDDSQWDATMANGALLKLPSALRHLFTTILQMSEPSDPKSLWDKYKDFLSEDIRREAQLLCPTMALTFNDEIYNTALIIIENLFVEMGESLATIGLPAPDRVASSSLSLEIVRET</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DYJ1</accession>
    <name>A0A812DYJ1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_61477</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004355">
        <property type="protein sequence ID" value="CAE1309826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DYJ1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="319"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="357"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1309826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="385" mass="46761" checksum="BB59E199626FEBA7" modified="2021-09-29" version="1">MLLGISAQSPLAKLSLSIYISFFLFFFLSSHHFSHLIYKFSLKFSFIFFFRSFVSYFSSFIFPSQIIFLSFFIFFLSFFLSIFLSLFFFFLSFFLSFFLSFFLSFASNFPSTSLNSPPSFLPSFLPSFLPSFLSFFLLQILHFKYSFLCSFSFLFFFFFLSFFFLFHVFKQFIIFFLSFFSFFSFFLFFFSLREFSFFFFSEYIFVFLLQMNYFFHSFLPWISSLSSFFSFFLPFIFFSLTCIISFLSFLSFFFSFLSFLSFLIFPFNFHNVEFSFFLSLFLLSPHPLHIIFFLSFLSFFLSFFYVFLSIFIMLNSLSFFLYFFFPPSALFISFLFFFLSFFYVFPFNFFLLLNSLSIFLFLLSPSTSHNFFLSFFFLSFFSFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DZT1</accession>
    <name>A0A812DZT1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_62066</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004404">
        <property type="protein sequence ID" value="CAE1310523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DZT1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1310523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="294" mass="35264" checksum="36D10624BEEA4257" modified="2021-09-29" version="1">MIFAYFIFICTFQFFLSFIFPPFSSFVLISPNPLQNQFYHLYLSLTCLPAFSIAFVLSFYHITFSFFLFLILLFYPSHPSLFLFLSLYFINLSFFLFSFILSYLSFFYDFLPLVLSFFLSFFLSFFLCMLFSVLSFFVLVLSLYSVDLSFFLSFFMLFLFSFSFYPSLLSDFSHLLFILIFNCSFSFLYFYPLIDFLFFSHSCFFLSFVYLYISFFLSFVFSLLLFICTSFFLVDPFISLIYVCMYVCMYVCISIYLSIYLSIYLNLFVIYLSIYLSIRDLSIYLNLFVIYLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E158</accession>
    <name>A0A812E158_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Biorientation of chromosomes in cell division protein 1,Biorientation of chromosomes in cell division protein 1-like 1,Biorientation of chromosomes in cell division protein 1-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SPHA_64544</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BOD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004635">
        <property type="protein sequence ID" value="CAE1313343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7605699at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055264">
        <property type="entry name" value="BOD1/SHG1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043244">
        <property type="entry name" value="BOD1L1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47391">
        <property type="entry name" value="BIORIENTATION OF CHROMOSOMES IN CELL DIVISION 1 LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47391:SF1">
        <property type="entry name" value="BIORIENTATION OF CHROMOSOMES IN CELL DIVISION 1 LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05205">
        <property type="entry name" value="COMPASS-Shg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BOD1/SHG1" evidence="5">
        <location>
            <begin position="19"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="191"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="361"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="490"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="661"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="872"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="968"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1329"/>
            <end position="1609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="230"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="251"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="361"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="405"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="420"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="507"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="553"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="666"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="688"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="711"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="741"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="764"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="824"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="880"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="896"/>
            <end position="909"/>
        </location>
    </feature>
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            <end position="1472"/>
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            <end position="1521"/>
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            <end position="1594"/>
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            <begin position="1595"/>
            <end position="1609"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF05205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAE1313343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1609" mass="175161" checksum="8EB855DA08C33862" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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    <name>A0A812E2G8_ACAPH</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">SPHA_65259</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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            <taxon>Coleoidea</taxon>
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            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
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    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E2G8"/>
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        </source>
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        <source>
            <dbReference type="EMBL" id="CAE1314249.1"/>
        </source>
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        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
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</entry>
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        <submittedName>
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        </submittedName>
    </protein>
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    </evidence>
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        <source>
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</entry>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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                <person name="Bekaert M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">Farmed</strain>
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    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </dbReference>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="290"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="343"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="406"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="432"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="460"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="489"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="534"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1316241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="554" mass="67295" checksum="59BF5CB8D4330DE7" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E6L4</accession>
    <name>A0A812E6L4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_68046</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004936">
        <property type="protein sequence ID" value="CAE1317496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E6L4"/>
    <dbReference type="OrthoDB" id="6161790at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134:SF22">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134">
        <property type="entry name" value="OS08G0543275 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1317496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="220" mass="26387" checksum="BF854E21547F08B1" modified="2021-09-29" version="1">MSSAFLRHRLLSSFVRLTPRIKCTNYRDQVICRDSYSHLSIYLSIYLSIYLSIYLCSYLSICDHMYVCMYVCMYVSIYLSIYLCLYLSICVHMFVSIYLSIYLSINHNLFIYIKSVSFWLSVYLSIYLSIYLSMFISIYPSVIICMYVCMYVCMYLSIYLSMFISIYLCSYVRIYLSIYLSIYLSINNNLFIYIPICFFLPIYLSIYLSILIEIRLFIQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E8A6</accession>
    <name>A0A812E8A6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RFA2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SPHA_67638</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the replication factor A protein 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004896">
        <property type="protein sequence ID" value="CAE1316859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E8A6"/>
    <dbReference type="OrthoDB" id="25571at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005662">
        <property type="term" value="C:DNA replication factor A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04478">
        <property type="entry name" value="RPA2_DBD_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000168">
        <property type="entry name" value="Replication protein A 32 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040260">
        <property type="entry name" value="RFA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014646">
        <property type="entry name" value="Rfa2/RPA32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014892">
        <property type="entry name" value="RPA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13989">
        <property type="entry name" value="REPLICATION PROTEIN A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13989:SF16">
        <property type="entry name" value="REPLICATION PROTEIN A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08784">
        <property type="entry name" value="RPA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036949">
        <property type="entry name" value="RPA32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Replication protein A C-terminal" evidence="7">
        <location>
            <begin position="167"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAE1316859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="258" mass="28966" checksum="D9B5A0F53B12AE3E" modified="2021-09-29" version="1">MWSTQSVDDSYNPNNDSLQGGYMAGRPGGEEDEKEDDLLNVVPVTIAEVLNATQSKSKFYSGKIPLSHVQIIGWVKSVEESSTRFDYEIEDYSGVPLTVKQFVLNEGQMNEDEKMKPFPEKTYVRACGKIRSFGGQRCVVAGRIFALSDMNELTTHLLEIIHGHMMFSTIQETNHKQSVNNNDYETSSFGIPGLGHLHNQVHQIIKSTPDDEGCDISKIFRQLRGVTENNIRDVIEFLSAEGHIYSTIDETHFKATDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ED83</accession>
    <name>A0A812ED83_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_70097</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005124">
        <property type="protein sequence ID" value="CAE1319785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ED83"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1319785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="264" mass="32741" checksum="7E78DFE5DBC9AD5F" modified="2021-09-29" version="1">MSFSFFLFFLSFLSFLCMTFLLPILFPLSFFLSFFPCSMTFLLPILCASYVFSFFLSFFLSFFLSFFLPYLVYDFSFYLFFVHPMSFFLSFFLSFFLSFFLPYLVYDFSFYLFFVHPMSFFLSFFLSFFLSFFLSFFFLPILCASYVFSFFLFFFISLFILFPFFYFFFFYFLFFLSFFFFPYFVYDFSFFPILCASFSFYLFFLPMSFFLSFFSFFLSFFLSFPTLCMTFFFFYLFFVHPMSFFLSFFLSFFLFFSFFFLPCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EDW7</accession>
    <name>A0A812EDW7_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA-5-taurinomethyluridine 2-sulfurtransferase</fullName>
            <ecNumber evidence="4">2.8.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SPHA_71274</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Farmed</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>5-taurinomethyluridine(34) in tRNA + S-sulfanyl-L-cysteinyl-[protein] + AH2 + ATP = 5-taurinomethyl-2-thiouridine(34) in tRNA + L-cysteinyl-[protein] + A + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:47040"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11726"/>
            <dbReference type="Rhea" id="RHEA-COMP:11732"/>
            <dbReference type="Rhea" id="RHEA-COMP:11733"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:87171"/>
            <dbReference type="ChEBI" id="CHEBI:87172"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.8.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MnmA/TRMU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.14" evidence="4"/>
    <dbReference type="EMBL" id="CAHIKZ030005218">
        <property type="protein sequence ID" value="CAE1321136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EDW7"/>
    <dbReference type="OrthoDB" id="3685at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061708">
        <property type="term" value="F:tRNA-5-taurinomethyluridine 2-sulfurtransferase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01998">
        <property type="entry name" value="MnmA_TRMU-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000104">
        <property type="entry name" value="Mitochondrial tRNA-specific 2-thiouridylase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.280:FF:000001">
        <property type="entry name" value="tRNA-specific 2-thiouridylase MnmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.280">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00144">
        <property type="entry name" value="tRNA_thiouridyl_MnmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004506">
        <property type="entry name" value="MnmA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046885">
        <property type="entry name" value="MnmA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046884">
        <property type="entry name" value="MnmA-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023382">
        <property type="entry name" value="MnmA-like_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11933:SF5">
        <property type="entry name" value="MITOCHONDRIAL TRNA-SPECIFIC 2-THIOURIDYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11933">
        <property type="entry name" value="TRNA 5-METHYLAMINOMETHYL-2-THIOURIDYLATE -METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03054">
        <property type="entry name" value="tRNA_Me_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20258">
        <property type="entry name" value="tRNA_Me_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20259">
        <property type="entry name" value="tRNA_Me_trans_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="5" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="tRNA-specific 2-thiouridylase MnmA-like central" evidence="14">
        <location>
            <begin position="239"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-specific 2-thiouridylase MnmA-like C-terminal" evidence="13">
        <location>
            <begin position="313"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF20258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF20259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAE1321136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="415" mass="46640" checksum="17F3746942CBBAD3" modified="2021-09-29" version="1">MSRNWKKIVCAISGGVDSAVAAILLKRRGYQVVGLFMKNWDIVDENGTCSINTDLEDAQFVCKQLKIPLYTVDFVKEYWNQVFSSFLQDYQKGLTPNPDILCNKHIKFDAFLKYAISRYGADAIATGHYACTSLNTTSFHRPPSSGEATKQTIRRNTSKSFGHSLALPTIKLLKAADAVKDQTFFLAQISQQALKKTLFPIGHLRKDQVRQIAIEENLQKIAKKKESMGICFIGSRNFKTFIKEYIEPLPGKFVNIETGKTLGQHEGIHMWTLGQRIHLGGCHHAYFVTEINSETNDIIVAPGTTHPALFCTSFKVDNPHWICPQPDWLESKSMAVDFRFQHAHPLITCELKSVSSDGSTCIVNLPHPMRAISPGQYAVFYKGDECIGSAQIKEVGPSLWKLNHREPIKLAKEFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EE64</accession>
    <name>A0A812EE64_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_71921</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005273">
        <property type="protein sequence ID" value="CAE1321896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EE64"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="336"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1321896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="393" mass="42429" checksum="2DCC744E5D9E1D11" modified="2021-09-29" version="1">MVDNMGKSCYSLSLSIYERYETLSVSLPVSLSLILSLSLPRFLVFSLAFSLSFSLSLSLSHLSLSLFLSLSLSFSLTRSLSLTLFLTLVSLSVSLSLIPSLSRSPSHSRFLSRFLPLAFSLSLSLSLSPPLSRFLSVSLSLSFTLPLNLVQEPVPKSLSVTNYFSPSNLSLSLSLSLSLFLFLSLFLSLFLSPSLSPPSSLSLSPSLSFSSPLSPLSPLSPLPLSQSLPLSPSPLSLLLPLSPRLSLSLSPLSLSPPSPSLSPSLSLSLSLKATWCTVIVSDPAVTDSHKIEDIKRPGNYTVRLSIHLKNGKTINILPTHIRIIQAMSSQSKRSSVVVGIVVSVCVVLIITFTAVILWRRRSRRCSSSNGYENKAFGLQLTESQKSNTSHLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EFC6</accession>
    <name>A0A812EFC6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_71510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005236">
        <property type="protein sequence ID" value="CAE1321414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EFC6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1321414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="200" mass="22760" checksum="B09878944CCC903F" modified="2021-09-29" version="1">MYFLVCLYLSIYLSKSIYLNVFSPYLSIYVYAASLSIYLSIYLSIYLSIYLSIYLSLFIIYLSIYLSIYLSIYLSKCIFLLVCLPMYINEPSLLFIYLRACLPLLSFFLIHLLSFSLYLFLFLFLSLSIYTVLYSPALLPTPPIPPLSLSLSLSLSLCLSLSLSLSLSLSLSFFLSNISIFPFTLMCLFHTAVSSHSTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EGD4</accession>
    <name>A0A812EGD4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_73947</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005400">
        <property type="protein sequence ID" value="CAE1324154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EGD4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
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            <begin position="20"/>
            <end position="49"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1324154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="167" mass="19590" checksum="F442610B572F116D" modified="2021-09-29" version="1">MYLNLFLSLSPSLSLSLYPSIYLSITIFSYLYLSISLNIFMSIIIFSYLSIYLSSYYNLFISIAINLSEYFHIYHNPFLSIYLSIYYNLFISIAINLSEYFHIYHNPFLSIYLSIYLSIYLSIYLSIYLTHESLHTRYALDRSTNCIADPFSMSALSQSLVRLFTQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EHA1</accession>
    <name>A0A812EHA1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_73689</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
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            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005385">
        <property type="protein sequence ID" value="CAE1323875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EHA1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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    </feature>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="228"/>
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        </location>
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        </location>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAE1323875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="696" mass="82718" checksum="FAFC04C7041A8D6B" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EHZ9</accession>
    <name>A0A812EHZ9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_75794</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Coleoidea</taxon>
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            <taxon>Sepiida</taxon>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005473">
        <property type="protein sequence ID" value="CAE1326211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EHZ9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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            <begin position="170"/>
            <end position="190"/>
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        <source>
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        </source>
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        <source>
            <dbReference type="EMBL" id="CAE1326211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="210" mass="25919" checksum="98D2011CD1849898" modified="2021-09-29" version="1">MPYSFSLSFFPSYFPSYIFVFLFLLFFFYNLKKIFCLLFLSFIFFYFYFPLLSLFSSSLFFFSLYSFNFFWFLHSFFFFFSFSFLILPFILLFSFFLSFILLHFFLFTFSFFIHHFSFPIYHFSFLSSCSLLLIFFFFVHYPSLSFFLSFFLSFFLSSFSPYLFPFLPLYISFCLFLTFPDFFHFFSRFLSSSAYPTVLRLPKISRYNLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EI91</accession>
    <name>A0A812EI91_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_71370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
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            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005222">
        <property type="protein sequence ID" value="CAE1321247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EI91"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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            <begin position="406"/>
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    </feature>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="428" mass="51440" checksum="4423E78AD546CA41" modified="2021-09-29" version="1">MNILHTHTHTHTHLSIYLSIYLSIYLSISVSADMIINEIEYIGAPNSLPFFISSILFHFFLSHLNSLPFFIFLIFFLFFTFCVFLSFLNFLYFFFHIYMLYLSLFPQFSSFFSFTFFAFFIFSIFFLFSFTFFAFLYFLNFLPFFLSHSLPFFIFSMFFLFSFTFFAFFPQFSFFFFLSLTFFVFFSISFFFFALPFYFTLFFLNIISVFYFYIHCIFSIHFSFSSSFLCLQIFPPMVKKISIYLSIYLSIYLSIYIYILIILLSFILILFYLLFNCFFPHLLIFLSVDLSISPFISLSYIYIYIYIYIPLLNPIFLYSSLSIFFLYPHHFFHLSVSISLSFLSFHSLFISFSSFSLFFSYLVLIFLTHYISLSFFLSFFLCNLILIFFVIVLSLCFLLHPSLSLFPILLPFLFFVLLYSSLPVLSWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EJE1</accession>
    <name>A0A812EJE1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_75596</name>
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    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
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        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005464">
        <property type="protein sequence ID" value="CAE1325982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EJE1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1325982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="156" mass="18250" checksum="43263B9512CC807C" modified="2021-09-29" version="1">MSSIDEKPLSWFIRLIHDTCIHLNKSMLLLCLFHSNSTMSSIDEKPLSWFIRLIHDTCIHLNKSCHSFELMRSLFSWFIRLIHDTCIHLNKSMLLLCLFHSYSTMSSIDEKPLSWFIRLIHDTCIHLNKSMLLLCLFHSNSTMSSIDEKPLHGSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EK63</accession>
    <name>A0A812EK63_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_72723</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005341">
        <property type="protein sequence ID" value="CAE1322789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EK63"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="349"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1322789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="376" mass="44380" checksum="B339DEB43BB71806" modified="2021-09-29" version="1">MSFILPAFYTYIFHTASLLYVFYTACHLYTCLLYCLPFILPVIYTHVFYTACLLYCLSFILPVFYTHVFYTACLLYTCLLYCLPFILPVFYTACLLHCLSFILPVFYIYVFYTACLLYICLLYICLLYCLSFIHMSFILSLLYICFYTALQEYSKFVSNIVLGASIFYTCIFYTVCLLSICLLYCLSFIHISFILSVLCICLLYCSLSICFLYYLSFMHMSSYTAFLLYIYILYYLSFIPISLILLVNTKVCSDAVIQTHFCRLIRYLSIYLSIYIYLSIYLSIYLSHSVHYLSIYLSIYLSIYPILQSFYPYKHTFVGSYDIYLSIYLSIYLSIYLSIYLSISFSSYLSIYLSIYLSIYLSIYLCVNRMLCSSFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EKD7</accession>
    <name>A0A812EKD7_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TGF-beta propeptide domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_72768</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005344">
        <property type="protein sequence ID" value="CAE1322896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EKD7"/>
    <dbReference type="OrthoDB" id="6092228at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001111">
        <property type="entry name" value="TGF-b_propeptide"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00688">
        <property type="entry name" value="TGFb_propeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="372"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="422"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="457"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="484"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="516"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="556"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="594"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="624"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="657"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="683"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="710"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="750"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="782"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="806"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="domain" description="TGF-beta propeptide" evidence="2">
        <location>
            <begin position="900"/>
            <end position="1004"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1322896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1065" mass="123668" checksum="16298150F1E84C32" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ELP3</accession>
    <name>A0A812ELP3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_78320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005535">
        <property type="protein sequence ID" value="CAE1328691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ELP3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="326"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1328691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="354" mass="42074" checksum="A781A7F7AD1058A8" modified="2021-09-29" version="1">MLSNNRVCDVGEVDDVALFTCKDGEGLVHHRPKVIFLAYVSFILLSFPSFLFKFLSLFLFFLSLHFYFTLFIFIHIFSFNRLIFFTYFSFTFSFLFSYVSFTSSVFSFLFLIFYILPFSFFRFYNSFFFFSLFFTFTFSFSFHSSILFILTLLSIISIFFVFTFISVFFLSSLFSLSVFHSNFFITFHLLFFVSFFFFRLLQIFFVDSFSLACDYFSFCSFSLLHLLETSSFLLFILFLPFFLLSFTHLSFLALYIFLSLSSTLFFFFHSLFFDSSPLFFIFIYSVSWSLSVCLSVCLTHCIYLSIYLSIFNYIYVFLCLGRSQSIYLSIYLSIYLSIYLFVGLSIYLSDYLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EN48</accession>
    <name>A0A812EN48_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_74298</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005415">
        <property type="protein sequence ID" value="CAE1324536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EN48"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032345804" evidence="2">
        <location>
            <begin position="20"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1324536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="211" mass="24153" checksum="5893E8525786E4DF" modified="2021-09-29" version="1">MLSFFRTCPLLSFVHCCHSSTAVIRPLLSFVHCCHSSTAVICPLLSFVHCCHSSTAVIRPLLSFVHCCHLSTAVIRPLLGIYLSIYLSIYLSIYLFLYINLYMTPNIKTNLSIYLSIYLSIYLVSFILCGVFSSNNLRWRPIRLKTSKIFIGQVDVPQQVSIQFAHCISYFSYLLSFFCSIFFVYFLSSPLKIFSLYFFPHPVKKGSTCLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ENC5</accession>
    <name>A0A812ENC5_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vesicular, overexpressed in cancer, prosurvival protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_76373</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005488">
        <property type="protein sequence ID" value="CAE1326814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ENC5"/>
    <dbReference type="OrthoDB" id="10070083at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032819971" description="Vesicular, overexpressed in cancer, prosurvival protein 1" evidence="2">
        <location>
            <begin position="24"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1326814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="190" mass="21594" checksum="55DEEBCE67420759" modified="2021-09-29" version="1">MAARVFLLTFLLVVILHHSQVAGYYCDSDRCGDDEYCCGYNICCKSYKVWELWYFWFGIAIILILLVIFGCFWKYQQNNNYLTISSEIPYTALPHGSVNPAPADSFKSVYPPDGNGGYYTRLMSPSQQLAFNNPGNQIHPVLGVCLLVLFFSCSGFFLFSKVLGLLVSSLMFAFWSCSFLVPDFFSSLRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ENJ2</accession>
    <name>A0A812ENJ2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_75727</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005470">
        <property type="protein sequence ID" value="CAE1326137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ENJ2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1326137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="375" mass="43989" checksum="26A1F5B141983C09" modified="2021-09-29" version="1">MQRVGVPSGVDEELLHHCLILFLLNLQLHFQPPPRPPPPSFFLSFFLSFLLYFFLPFFFLPFFLSFFLFSFFLTFFFSFFLSFFLSFFLFSFFLSYFISFFLFSFFLSSFLSFFFLSFLLSFFLSFFLSSFLSSFFLSFFLSFFLSFFLSFFLCIVLFLLQLLFFNLLLYLSHILKNSTTPLLPLPTALHAHPLSVCLSFFLTLSLSRFLSLSFRLILAHSAFFKSNHHAKTRTYLGRYKFLSYQVRYLHVRTDLSLSLPLPLSLSQSLFFSLSQSPSFFHSLSFSLALLFFPSLSLSVSLFLSLCYTLSGLPLSNSCQVPSSHSFCLFRRALNVPRDRSIRHTFSILISSRKTDSCRHFAKITKYYNGCYEKTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ERQ0</accession>
    <name>A0A812ERQ0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_79638</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005574">
        <property type="protein sequence ID" value="CAE1330328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ERQ0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1330328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="220" mass="24721" checksum="57BEE44B87648DD0" modified="2021-09-29" version="1">MADINKQTLVDKCRSPINKQTLVDKCRSPINKQTLVDKCRSPINKQTLVDKCRSPINKQTLVDKCRSPINKQDVSRQVSIAYQQADVSRQVSIAYQQADVSRQVSIAYQQADVSRQVSIAYQQADVSRQVSIAYQQADVSRQVSIAYQQADVSRQVSIAYQQADVSRQVSIAYQQADVSRQVSIAYQQADVSRQVSIAYQQADVSRQVSIAYQQVDVSLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ESC3</accession>
    <name>A0A812ESC3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_76599</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005494">
        <property type="protein sequence ID" value="CAE1327064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ESC3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1327064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="323" mass="36356" checksum="BB4E3F63FC620E6E" modified="2021-09-29" version="1">MSPSVEQYPPSKHPLPQQERKEIGRIDVFSSLDIPYPTDTHAHGTPFHVELGSTFFFFFFFFLSLSLKHFSFFCSQFSFTVLYNTHTSSYDSLSLSLSLSLVLNGMRKTYHVFEAHVSLFSSSSSSSSSSSSLSSSSSSSFVLLLLFFFVLLLLFFFVLLLLFFFVLLLLLFFVLLLLFFFVLLLLFFFPLSLSFSPLSFSLCASLSPNIFPMLHISFLSLSFSCYASLHVPSHATPLSMFLLMPRLSPCSFSCHASLHVPSHATPQLPFSLLPLSLAHLSPTLHLPHPFSFFAHFSLSLSHSSSQTVHFSPHLHYIAHLLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ESZ4</accession>
    <name>A0A812ESZ4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_76794</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005498">
        <property type="protein sequence ID" value="CAE1327413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ESZ4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1327413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="164" mass="19385" checksum="0CD319CDE1566CBD" modified="2021-09-29" version="1">MYLLFFSLISLSPFSFFLFRSLSLSHFFFSLSFLSISLSFILFSLSCFSDFLLFSFSLFLSFLSFLFLSFPFLPLFLFSLSLSSFFLSFFLSFFSLSLYISLFLYLYIVRNFMSSLYLPHYHYIYLSIYLSIYLSIYLSQSVHNLPIYLLNILLPPSLSLSIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EXX7</accession>
    <name>A0A812EXX7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_79165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005560">
        <property type="protein sequence ID" value="CAE1329775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EXX7"/>
    <dbReference type="OrthoDB" id="5984344at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47018">
        <property type="entry name" value="CXC DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47018:SF1">
        <property type="entry name" value="TESMIN_TSO1-LIKE CXC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032669082" evidence="1">
        <location>
            <begin position="20"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1329775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="245" mass="27792" checksum="C7C55D2C6B88212E" modified="2021-09-29" version="1">MVPSMELVILLLIRSFGEANFFLYCQLLAELISYFFANNNVSYAQWIPIHYRDMLPLEQKHPQLAQEFQSGNFVVHESSRQLPAVAMGQAHEQVHAVIKSNEGAIGVTEDQSALRRWMIAAPEVTWLHSMRQHEGTEHTTSHHEETGRAQRVFLEKVEKMQDMGMFGACFRLISSTAEGVDDSRFDSEVDAIRNHSSNPSSAEATREACCLRQLETQAPANWGWTKKGDLWLIVWTELPSIAESC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AIY5</accession>
    <name>A0A812AIY5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_252</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000003">
        <property type="protein sequence ID" value="CAE1138692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AIY5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1138692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="174" mass="19615" checksum="989190B9D8DF4F97" modified="2021-09-29" version="1">MTFPFNTIVFIYNNIIIRYYQCRPRHIYESCILTCYPLPTHLPSFPASPAILFCLTFYPLLLHLLFSSTSPAIFFRLTCYPLLPHLLSSSTAPAIFSRLTCYSLPPHLPSSPTSPAILFRLTCYPLPPHLLSSSDSPAILFYFTCYSLLLHLLSSSASPAIFSRLTCHPLPPNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ANF4</accession>
    <name>A0A812ANF4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_2153</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000061">
        <property type="protein sequence ID" value="CAE1147533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ANF4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1147533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="297" mass="34527" checksum="97917D0D0A46711D" modified="2021-09-29" version="1">MRSLFFSFLLLFFSFLIPLSLNLSFPISSFFFLMRSTLFLFLFFSLFLTFHSSVSPPHLSFPFPPSFLNRSSFLFLFYSLFLTFSFLCLSPTSFFPYFLLLSLNAIHSFSLSLLLSFSHFFIPLSPTHIFLSLFPPSFSKCDPFSFLFSLFYSLFSLSHSSVSPTSFSFPYFSIFFSLNAIHSFFFSLLSFFTFSFFSHLSFPFLIPLSLFTHFLFFPFSFSLHLSLNAIPLFSFSFTLFSHFLIPLSLTHIFLSLFPQSFSKCDPSFLFLFYSLFSLSHSSVSHPHLSFHISSIFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ANQ4</accession>
    <name>A0A812ANQ4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_2803</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000081">
        <property type="protein sequence ID" value="CAE1149909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ANQ4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134:SF22">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134">
        <property type="entry name" value="OS08G0543275 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="325"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1149909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="358" mass="41978" checksum="8B4E50E87C02B005" modified="2021-09-29" version="1">MPICPYLSIYICLYLSIYLSIYLSIYLSIYLSITVYSLSIYLSIYLSIYLSIYLSIWSSCLSIYLPICISICHSISIYLSMFIYIYLQHVHIYLSCISIYSFISIYLSIYLSIYLSHLSICIYVSNNLCSYLSIYLSIYLSIYLSIYLSIYVKLFISIYLSIYLSISVCSCLSLYISLYLTNSVDSLSIYLFISIYQIRLGLIISIYLSICLSISVCSCLSLYLSLSNCVDSLSIYLSIYLSIYLSVCLSVCLSLSFHIYLCIYLSCMFIPNFLYIYLTQPVHYLSIYLSIYLSIYLSIYLYVCMYQSIYLCSYQSISQSVHISIYMYLSIFIYMFFIFIYMFLFTYLSIFYLSTYLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ANT7</accession>
    <name>A0A812ANT7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_1533</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000043">
        <property type="protein sequence ID" value="CAE1144981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ANT7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1144981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="280" mass="33130" checksum="2C3DF97712585083" modified="2021-09-29" version="1">MGLLIYNSLFAIYSLFFFFFFFFFFFFFFFFFFFSVVVIVFCSSFFLSFFLSFFLSFFLSFFLVVALFLKNFSFLPSFLPSFLPSFLPRSCSFPHFLYFFMISFFPLYPSFSFLLLLPHSLIRHSNISSSIMSISICLLFLSFFSFFLSFFLSFFLCHISFPILFSSSLFSSLFFFFFFPLLPYPLSLFSSLSSSPLSSSFLSSSLYFPHFLPSPPHPFFIFFSLFYFSFSSFSSPYLHTFSIKSVHYHLIIFPFFISSFSFSSTFLSFFLFSFFLSSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ARR0</accession>
    <name>A0A812ARR0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_3898</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000118">
        <property type="protein sequence ID" value="CAE1153520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ARR0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="375"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1153520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="401" mass="46138" checksum="3A3EE097109C9D51" modified="2021-09-29" version="1">MNGPAIASTSQPSIELSAHFPSTCCLSSRSCGLIGLINHTLSEIGSLSIFDFLPISLNGFLFYTYTHNSSVPIIPLFSLLDHIFLSAPTSPSLCPYLSTFIGSYLSFSLSPLLLSHRSVTFYLTFSVSYLSLSLSLSFYIFQQLVQTYLSLSVLRFSLFVHNFIFLSSPKRIYFYPFLSQSIHFYPPFLFVSNTFSSLLLSLSLSLYFKAITGPGFFYLFCLLKQIFLPFDQPIHFFFLFLRPYISIFPFFISQTIFSHNDWFTLFYLSRCQIVFCYPSLQSIHILSLCWSIHLDLCERLSFFHINPIYLYSFLSQSISILYIYNAFSLSPYQSPIFILLSHSAHVNPIYLYSFLTQSISIAYLYCFLTQSMSIPYIYIAFSLSPYQPPIFILLSLSYFLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AUI5</accession>
    <name>A0A812AUI5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_7173</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000231">
        <property type="protein sequence ID" value="CAE1162141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AUI5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1162141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="165" mass="20827" checksum="9FFB4673982A5DE6" modified="2021-09-29" version="1">MFLSFFLSFFLSFFLSFHVFFVFFYLLFLFSSFFFPNLLFFYFCLPFLSFFSNPYPLLLHFLTFSFFLLHTLSFFLSFFLSFFLSFFLSFHIFFLFFYFYLFFFLFLFFPNLLFYFCLHFLSFFLSFFLSFFLSFFLSFFLFCPLRKEEEQRTNEQLSYRKLKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AUZ3</accession>
    <name>A0A812AUZ3_ACAPH</name>
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        <submittedName>
            <fullName evidence="4">PLCE</fullName>
            <ecNumber evidence="4">3.1.4.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SPHA_5129</name>
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    <organism evidence="4 5">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
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    <reference evidence="4" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="4"/>
    <dbReference type="EMBL" id="CAHIKZ030000170">
        <property type="protein sequence ID" value="CAE1157294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="269822at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="131"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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            <end position="212"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="2">
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    <feature type="transmembrane region" description="Helical" evidence="2">
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    <feature type="transmembrane region" description="Helical" evidence="2">
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            <end position="1810"/>
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            <end position="475"/>
        </location>
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            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="337"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAE1157294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1837" mass="212500" checksum="9FFB3DAEC5FE3854" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AXZ1</accession>
    <name>A0A812AXZ1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_7591</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
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            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
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            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000242">
        <property type="protein sequence ID" value="CAE1163116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AXZ1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <source>
            <dbReference type="EMBL" id="CAE1163116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="497" mass="58774" checksum="A9614F18C425AA4B" modified="2021-09-29" version="1">MTSPYAPSYEFTTPPSSLCYVASELFISVCLSVYLSIYLSHLFISISFCSYLSIYLSIYLSIYLSIYLSIYLSLFISISFYLYMSIYLIFSYLSISVCSYLILFISISFCSYLSIHRSNLLCSYVSIYASIYLVCSNLSIYLSFFLGLFISIYLSIYLSIYLSIYLSFFLSFFLSFFLGLFISIYLSIYLSIYLSIYLSIFLSFFLSFFLGLFISIYLSIYLSIYLSFSVCSYLSIYLSIYLSFFLSFFLGLFISIYLSIYLSIYLSFFLSFFLSFSVCSYLSIYLSIYLSIYLSFFFFFLGLFISIYLSIYLSFFLSFFLSRSVHIYLSIYLSIYLSIYLSFFLSLSVHIYLFIYLICYFFGTVSFLICFFFRKKRQSSSPGDTQNNLRYQQFNLSIYLSIYLSSSLHYLSIYLSIYLSIFVSSLSIYLSIYLSIFNAFISFLLFSFLNVFISFLLFSFQNSVIFFPEYFYFLYFLSRMLLFPFFIFFPESFYFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AZB0</accession>
    <name>A0A812AZB0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_7985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
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                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000258">
        <property type="protein sequence ID" value="CAE1164317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A812AZB0"/>
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            <begin position="32"/>
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            <begin position="59"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="126"/>
            <end position="150"/>
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        <location>
            <begin position="176"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1164317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="205" mass="24123" checksum="C03DBECAE0E5F9B1" modified="2021-09-29" version="1">MLWECPCSPNNQSGLSLQMSKYGGVPPPSLEFYLGLFLVTCSNPSPSCLVLLYHLNIFLSFFLSFFPSFFLSFFLSFHYNKHSSSVSLEFLSFFLSFFLSFFLSFFSFLFFFHYNNHSVQNLLYHLNFFLSFFLSFLLSFFLSFFLSFHYNNPSDQKSLVIHANVHMLMSSVSLEFLSFFLSFFLSFFLSFFLFIITILLSKSLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B316</accession>
    <name>A0A812B316_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_9147</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
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            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
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    <sequence length="172" mass="20095" checksum="75E6F0116789321E" modified="2021-09-29" version="1">MDNIQIRTIFLFQFKLGRKAAETALLSQFIISLFLSLSLSLTLSFSLSTYLSSYLNVEIWLIKMILRCHLLVVLSTFIYIYIYIYIYTTLTLSIYLSIYLSIYLILFISISFYSYLSICLLQSVYIYLSISVYSYFSISVCPHLSIYLSLARFIYLSLVRSLSISIYLSIYL</sequence>
</entry>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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    </evidence>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
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    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000424">
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
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    </dbReference>
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        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1173578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="260" mass="30548" checksum="9130F0A87E8C7E3F" modified="2021-09-29" version="1">MIHCLLLFIFSHFFFLAFIFPYELSSFITSRTPAHAHTSCVRRLFICQPLARFTLLATLSIYLSIYLSIYLSTCLSVCLSLCVSIYLSIYLSIYLFQGINYIYLSIYLSLAICLCVCLSVCLSIYLSIYLFQGINYICLSIYHFRALIISIYLSIYLSIYIRAFIISVCLSIYLSGIHYIYHTVCLSVYLSIYLSIWFNLASRHFSFFFLSFFLFLSFCLSFFFLFFSCISFFLAINSFFDFHLLKERRNSLKIPFFPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B9F4</accession>
    <name>A0A812B9F4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_12151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000403">
        <property type="protein sequence ID" value="CAE1172589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B9F4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1172589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="202" mass="23350" checksum="EC7A1D9F78007463" modified="2021-09-29" version="1">MQRAAHTFLLSSSSTFPAGVIIMPPNARIASIPIFLSFFLSFFLSFFLSFFLACFSCVFSPLSTFLSLSLSLSLSLSLSPLHYIENLIICWILSHPIHIYLSIYLSIYLFHQFISDYLSIYLSIYLSIYFSLFICNILSIHLFHQFICIFLSSYLSIYLSISVCLYVTFYLSIHLFHQFICIFLSSYLSIYLCLLSVHVSHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BBH8</accession>
    <name>A0A812BBH8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_13627</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000458">
        <property type="protein sequence ID" value="CAE1175480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BBH8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1175480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="150" mass="17507" checksum="11222DEF5D0E3449" modified="2021-09-29" version="1">MKLYLNSYWKADVRIEWVTEDTKEIKYVKQTDGRRETTLTFQKFLSFFFSFLCRQGSLLGDQTPFFLYLFSSRPPGNYAFLLRPLEGENLLKHALRTPLMNFFSTFFSGASSRGLLKTFSEGETCPQQLSYSCILLLWANAACLFSRERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BBL1</accession>
    <name>A0A812BBL1_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Kinesin light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SPHA_13596</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Farmed</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Kinesin is a microtubule-associated force-producing protein that play a role in organelle transport.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Oligomeric complex composed of two heavy chains and two light chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
            <location evidence="1 11">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the kinesin light chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000458">
        <property type="protein sequence ID" value="CAE1175481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BBL1"/>
    <dbReference type="OrthoDB" id="5986190at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019894">
        <property type="term" value="F:kinesin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002151">
        <property type="entry name" value="Kinesin_light"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45783">
        <property type="entry name" value="KINESIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45783:SF3">
        <property type="entry name" value="KINESIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00381">
        <property type="entry name" value="KINESINLIGHT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 10" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="151"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="193"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAE1175481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="404" mass="46578" checksum="C8F9AB449CC0779C" modified="2021-09-29" version="1">MFLANHLQYLEGEKLKLRAQVSLLKEENDWLRKELLETQGDLMKCQQKLVVVEEKNKHFEFMKELKMDDSREGSEEGSEGSGRPFSFDMSFLDDLPSDTGSPGYEIPARFRSLYDLVTQYVAQGRHQVALTLCKQSIQNLEKTCQYNPDEAIVLHMQARIYKDMGNTREAIKSLQSALHIRENTLGHDHSSVAALLNNLAVMYGRNGNYKDAENMCKRALEIKEKLFGTYHTAVAKLFNNLALLCQNQNKYDQAEYYYHRALEIYHTILGPDHVTVMKTKNNRASAFLRQGKYRQAEEIYKDILIQFCEKEYGHFEDDNNRPQLTPAEQENGGILLYYIKRLCDRCKMGLDVFKNPALITALVNMGILNRIIGKSDEAALFEESVVRLKKKNSHYKLMTVSTES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BFK4</accession>
    <name>A0A812BFK4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_19167</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000695">
        <property type="protein sequence ID" value="CAE1233928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BFK4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1233928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="196" mass="24053" checksum="6629A68D9DABDF0D" modified="2021-09-29" version="1">MFLSFLILFLYYFSISNCFSLPLDFFITSFVCLHVFFFLSFFLSFFLSFFLSFFLFIYFFALRFFLSFFLSFFLFLSFFYYFDMQSLLSYLCLFYNHFSHSFFLSFFLSFFLSFFLSFFLLLFRYALLLSYPCLFIINSFFLSFFLSFFLSFFLSFFSDFFLSFFLSFFLSFFLSPTFFLLQFLSNRLNPSFISAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BFZ9</accession>
    <name>A0A812BFZ9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_19364</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000704">
        <property type="protein sequence ID" value="CAE1234467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BFZ9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="348"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="386"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="410"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1026"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1125"/>
            <end position="1147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1234467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1148" mass="133838" checksum="76F9DFD97EE36157" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BGX6</accession>
    <name>A0A812BGX6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_15410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000535">
        <property type="protein sequence ID" value="CAE1178773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BGX6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134:SF22">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134">
        <property type="entry name" value="OS08G0543275 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="344"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="374"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="407"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="437"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="467"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="498"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="565"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="619"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="658"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1178773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="680" mass="80525" checksum="5C60290B39E9EDB9" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BIA6</accession>
    <name>A0A812BIA6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protein dopey-1 homolog,Protein pad-1,Protein dopey-2,Protein dopey-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SPHA_16127</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Farmed</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DOP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000563">
        <property type="protein sequence ID" value="CAE1226689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="297643at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040314">
        <property type="entry name" value="DOP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056457">
        <property type="entry name" value="DOP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007249">
        <property type="entry name" value="DOP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056459">
        <property type="entry name" value="TPR_DOP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14042">
        <property type="entry name" value="DOPEY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14042:SF24">
        <property type="entry name" value="PROTEIN DOPEY-1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24598">
        <property type="entry name" value="DOP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04118">
        <property type="entry name" value="Dopey_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24601">
        <property type="entry name" value="TPR_DOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="2217"/>
            <end position="2239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="2245"/>
            <end position="2269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="2276"/>
            <end position="2299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="2305"/>
            <end position="2326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="2333"/>
            <end position="2352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="2358"/>
            <end position="2381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="2388"/>
            <end position="2416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="2422"/>
            <end position="2444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="2451"/>
            <end position="2472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="2478"/>
            <end position="2501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="2513"/>
            <end position="2536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="2542"/>
            <end position="2565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="2572"/>
            <end position="2594"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="2600"/>
            <end position="2621"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="2626"/>
            <end position="2646"/>
        </location>
    </feature>
    <feature type="domain" description="DOP1 N-terminal" evidence="6">
        <location>
            <begin position="14"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="DOP1-like TPR" evidence="8">
        <location>
            <begin position="1310"/>
            <end position="1691"/>
        </location>
    </feature>
    <feature type="domain" description="DOP1-like C-terminal" evidence="7">
        <location>
            <begin position="1929"/>
            <end position="2232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="571"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1266"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1546"/>
            <end position="1574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="600"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="611"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1288"/>
            <end position="1300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1546"/>
            <end position="1561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00046326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAE1226689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="2770" mass="315979" checksum="E9B54785BF5E4A40" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BIU9</accession>
    <name>A0A812BIU9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_17448</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000623">
        <property type="protein sequence ID" value="CAE1229791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BIU9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="321"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="367"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="404"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="448"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="482"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="508"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="566"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="596"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="628"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="676"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="702"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="820"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="864"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="995"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1093"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1125"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1167"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1200"/>
            <end position="1218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1229791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1226" mass="139448" checksum="826C03B7EC630A39" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BJC3</accession>
    <name>A0A812BJC3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="14">GRIK3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SPHA_19755</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000718">
        <property type="protein sequence ID" value="CAE1235372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BJC3"/>
    <dbReference type="OrthoDB" id="5984008at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000024">
        <property type="entry name" value="Glutamate receptor, ionotropic, delta 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000143">
        <property type="entry name" value="Probable glutamate receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015683">
        <property type="entry name" value="Ionotropic_Glu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18966">
        <property type="entry name" value="IONOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="200"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="12">
        <location>
            <begin position="14"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="13">
        <location>
            <begin position="25"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAE1235372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="356" mass="40812" checksum="3034C644626BA1CB" modified="2021-09-29" version="1">MYLFLFQEPPFIQKRNSTDSLLDDPVITKNNTRLEGFCIDILKAMSRLLKFQYTIYLAPDGKYGSKKKHGWTGMVRELIDNKADMALAPFSVTPERSSVVDFTKSFMTKGTTVVVKKPQRTVWMFQFLFPLSNYVWIAIFVSFVVVSLALFGVSRVNADKHRKYTHNFLESFWYIWGTLLRGSLKSSPLAVSSRIISSSWWLFSLIIISVYTANLAAFLTVTNIYLPIENAADLAFQNTYDYGTVNGSQIEDFFKHTNISHYSKMWLHMKLTPGSIVQRVEHGLERARNSKYAFIWDSPTLRWEIADKCDLMEIGNPFDLKGYGFAVRKDTPFTEALSNAILKLGDTGERQKIEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BKK1</accession>
    <name>A0A812BKK1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_19376</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000704">
        <property type="protein sequence ID" value="CAE1234441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BKK1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1234441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="222" mass="26326" checksum="5670B01DCB2F450A" modified="2021-09-29" version="1">MFVHLSAMTLFNTAISSSSLSSFFLSFFLSLTTLIYFFLSFFSPRFLSSYYDVFLLSVFSFFLLSFFLILLILSCFPFFFLSFFLSFFLSFFLSTSSSFALHIDFSFFLSLFFSLTHSRIVPPLNLSFFLSFFLSYPTLMFPFLSFFFLSFFLSTSLSFALHIDFSFFLSFFLSFFLSFFLSFFLSFFSPRSFFIPLLRYLNPFFLSFFLSFVSLSFFLFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BL21</accession>
    <name>A0A812BL21_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_18630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000671">
        <property type="protein sequence ID" value="CAE1232657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BL21"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1232657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="212" mass="24190" checksum="CE9FDBE2835F4BCA" modified="2021-09-29" version="1">MLKDGSLNAGERCSKENLVIGNVVLRTDAKDFSVLRLLEPLQMFDDPSIVQIFYLSIYLSIYFISLFLSLSLSHSIYLSIYLSIYLSLPAVSLSVRRREQYLLRCLSPRCLHVLGVLFLWTHAQELGWCMMYSGYASVLQTTNQGSPCKRPNIEEPIQPWNSTCAFFLLCMSASHQDYPRNVESLPLSLKFHLGLLFIGHLIKTVHQRLGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BSH8</accession>
    <name>A0A812BSH8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_20922</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000767">
        <property type="protein sequence ID" value="CAE1237735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BSH8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="335"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="368"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="424"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="494"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="519"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1237735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="536" mass="62648" checksum="376D6E40256E0715" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BTK0</accession>
    <name>A0A812BTK0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_23771</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000880">
        <property type="protein sequence ID" value="CAE1243363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BTK0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032305558" evidence="2">
        <location>
            <begin position="19"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1243363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="205" mass="22849" checksum="E53EDC95727EDC24" modified="2021-09-29" version="1">MFLRHWVSPTFLTLSALPSFLPRSSPPSSVILSASPTFVTLSASPSFLTLTVSPSFVPICGSSPHHLLFIIPNIFKALRITIIFKHIGVTSLRITNIFTHLLITFICNSHSITIIFNPNGIAIILNLPVSPLFVLISISPSFVTLLKSPSCLSHHHHLHPCPHHQHLYPPLLHTIICTRLSAYLLFEPSPYSHHSYPLSSLYNFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BUQ4</accession>
    <name>A0A812BUQ4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_24472</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000913">
        <property type="protein sequence ID" value="CAE1244791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BUQ4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1244791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="336" mass="41202" checksum="1655C0A3C60C057F" modified="2021-09-29" version="1">MIILINISIYLYSCSFIISSLISYNILFLIYLSIYLSIYLSIYSNLIHNTLTIYYSLFFFFFFCFFFLSFLFFFVFVFFFFFFLLLLLLLFLFSSNLSFVDFFIFFFLSYHHILFSINWIFFSLPFLLHFSFHSLLQLHLFLFSSFFSFFFFFSFFFFYFTFSSFFFSNFFFFLSFSPFFSFLSSFFSSFTYLLLIFIRPFQFVIVFSFCLSFFLFSFSFSAFLTSILIYFYFLSFLPCIYVLFFSCSSFHCFLFTLCPPHLYCLLFHHLPFITSFLSLRFQRHPLSPDIRPPVFPLLCNVGFFLWKTFYVFSLQRTLLYLPNEYFTEIEQWQKCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BV33</accession>
    <name>A0A812BV33_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_25958</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000989">
        <property type="protein sequence ID" value="CAE1248025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BV33"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1248025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="155" mass="18449" checksum="5869AEF2D6D1EF61" modified="2021-09-29" version="1">MHRNFQTEYPPSRLSIYLSIYLSIYLSIYLSIYFSVIISIYLFQFLSYLSISVLFIHLSIYLSIYLSIYLSIYLFHLFISITLFHSYHNCLTICLSIYLSITLFLSFSLSLYLSIYLSLFISIYLSIYLSIYLSIYLSIYHSLYTSIYVFILLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BWY7</accession>
    <name>A0A812BWY7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NLGN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SPHA_23706</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Farmed</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000878">
        <property type="protein sequence ID" value="CAE1243227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BWY7"/>
    <dbReference type="OrthoDB" id="3200163at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051093">
        <property type="entry name" value="Neuroligin/BSAL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43903">
        <property type="entry name" value="NEUROLIGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="106"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAE1243227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="231" mass="25720" checksum="431723CC77465CA7" modified="2021-09-29" version="1">MKMTTNLTTASYIPSANASTATAAIISASSAPSLVTSSNEPNTTKSSRKGSDDLTKKKISLTVEKLKQKTKFLLLIQLSLLLATLEITLVTESARAQDAFDKIISERIIETKYGKIRGVQILFRKDLLLRPVDAYLGIPYASFRKDAMRFMPPGNPPFRWDGTSPVLKRPPRKHFISIYLSIYLSIYISVKISFSLSHPTTQFSWPILSNKRVGYCLSQHLSVVIGLFISC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BXM2</accession>
    <name>A0A812BXM2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="13">KRAB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SPHA_24073</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000893">
        <property type="protein sequence ID" value="CAE1243950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BXM2"/>
    <dbReference type="OrthoDB" id="9439254at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000621">
        <property type="entry name" value="FLT3-interacting zinc finger 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001485">
        <property type="entry name" value="Krueppel-related zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000702">
        <property type="entry name" value="Transcription factor E4F1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000086">
        <property type="entry name" value="transcription factor E4F1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000325">
        <property type="entry name" value="ZFP90 zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000557">
        <property type="entry name" value="zinc finger and SCAN domain-containing protein 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000744">
        <property type="entry name" value="zinc finger E-box-binding homeobox 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001506">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000139">
        <property type="entry name" value="zinc finger protein 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000072">
        <property type="entry name" value="zinc finger protein 143 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000495">
        <property type="entry name" value="zinc finger protein 668"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050752">
        <property type="entry name" value="C2H2-ZF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24384:SF189">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24384">
        <property type="entry name" value="FINGER PUTATIVE TRANSCRIPTION FACTOR FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="15"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="96"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="124"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="152"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="209"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="237"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="265"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="293"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="321"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="428"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="456"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="484"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="512"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="540"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="568"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAE1243950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="678" mass="76137" checksum="DA8BC94265F0C0AA" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BXU9</accession>
    <name>A0A812BXU9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_24762</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000930">
        <property type="protein sequence ID" value="CAE1245535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BXU9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="266"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="317"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="339"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1245535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="364" mass="43035" checksum="0FE4579677FFCFCF" modified="2021-09-29" version="1">MPSHFYIRCLDVVCRPTPRSRDGRRHTSTSPPPTFPVAYIGIQLVAKHDVRERRHRFAKRHVTVSHDSVPAMTQPFLLLSRSLAQTAHPSQFFSFSHFPHFSLSLSLSISLSFSLVQFTDFTLYPTKQWEGISIYLSIYLSIYPEQFKIYHDQFNLSLSLSFFLSRPIHYLSIYLSIYLSIYLSILHCPYLSINLRLFISIYLSILVCSYLSIYLSIYLPIYLSILHCPYRTVQDLSRPVQSLSFFIYLFIYFFLSFFLSRPIQYLSIYLSIYLSIYLSIYLSRTVQDLFSFSSIFFLSFFLSFFLSFFLSTFFHDLSIYLSIYLSIYLSIYHDQFNLSLFLFLYIYLSIYLSIYLSIYLSICS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BY83</accession>
    <name>A0A812BY83_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_26307</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001004">
        <property type="protein sequence ID" value="CAE1248768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BY83"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
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    </evidence>
    <sequence length="459" mass="53633" checksum="19BA0FBBDA6383DC" modified="2021-09-29" version="1">MYVCMYVRIYLSIYLYIYLSIYLSICISLFISIYISINQSMNVSIIYLSIYLSIYLCPLSIYLSIYLSIYLSIYLSECVHYLSIYVHIYLSIYLSSSVYIYLSIYLSIYLSIYLSRHISIMVDIYLSNYVFNHIHQSALHDRLEKFRNSLSDSVRRSSPLSILSVFFSFYLSVFLSTYHLFFLIIYLSIYLSIYLSIYLSIFVCSYLSIYLSIYLSISVWSLSIYLSIYLSQSGHYLSIYLSISVWSLSIYLSIYLSIYLSQSGHYLSIYLSIYPSIYLSLVIIYLSIYLSQSELSIYPSIYPSIYLSIYLSQSGHYPIYPSIYLSLVIYLSIHLSIYLSIYLSISVQSLSIYLSIYLSIYLSQSSHLSIYLSIYLSILSIYLSLVIIHLSIYLSIYLSQSSHYLSIYLSIYLSQSGHYLSIYLSIYLSRILLSIYLSIHSSIYLSIYLSISTFLSYLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BZK0</accession>
    <name>A0A812BZK0_ACAPH</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <dbReference type="NCBI Taxonomy" id="158019"/>
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            <taxon>Coleoidea</taxon>
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            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
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    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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    <organism evidence="2 3">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">Farmed</strain>
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    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="project" value="InterPro"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1140" mass="137354" checksum="ACD74B1898E85FB9" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C268</accession>
    <name>A0A812C268_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <organism evidence="2 3">
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        <dbReference type="NCBI Taxonomy" id="158019"/>
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            <authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <source>
            <dbReference type="EMBL" id="CAE1253055.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="269" mass="31846" checksum="0E0BE8BB61B6925A" modified="2021-09-29" version="1">MFFFIFFLHCFPAFFFIFAYIQFLSSFFFLFLSNSSPSFVVASCLFFSLFLRFLSLSFFLRSYFLSFLSSSFFLFLLHSSLTFFSRHFFLHSSSYFPVFFFFFGFLSSFFLPFLFSSYFLFILYSSFTVFRRNLFFFMVFPISFFLLSFFSFFTFFSLFFSASLSFTHFYCFSSSFLNILPFFISFSVSYSFHFISYLPASFFHHFFYLLICPPFFFLSPFSTFPLSPSLSPSLSLSLSLSPSLSLSLSLSLSHTCTFSLSSNHFLIYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C3G5</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
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        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001160">
        <property type="protein sequence ID" value="CAE1254898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C3G5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1254898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="160" mass="17573" checksum="B38A3B2A2FB6A6B5" modified="2021-09-29" version="1">MSSACKCLTDHGHYNCPSQQATLWSGVPAAQTPEPGNSLSSHSRRGQHSGDQLGHGRKGSASGLPRDMVYQMQSQIFFCTSHNLLWGRGGGRRGKILLPSYHPSLSISFFPLLSLSLSLSKVEQKKSKNIFSPFSLFPLQSCVMKKYSYTSSQSLHINGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C4B1</accession>
    <name>A0A812C4B1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_26858</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001027">
        <property type="protein sequence ID" value="CAE1249919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C4B1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1249919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="222" mass="26071" checksum="E20D61831E830D88" modified="2021-09-29" version="1">MWHFFLLPSGISFLSFFLLCAFLFSSLWHFFSLPGGISFLFSSLWHFFSLPSGISFLFSSLWHFFFLLSGISFLFPSRWHFFSLLSGISFLFHSRWHFFSFPFSVAFLFPSRWHFFSFPFPVAFLFFSLPGGISFPFPVAFIFPSLWHFFSIPSGISFPSSVSFLLCSISSSFMGHRPSLQLFISIYLSIYLSIYLSIYLSLYIYIYIYIYTHTHTHQGLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C572</accession>
    <name>A0A812C572_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">INO80D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SPHA_29760</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001191">
        <property type="protein sequence ID" value="CAE1255675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10038011at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025927">
        <property type="entry name" value="Znf_KANL2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16198">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16198:SF2">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13891">
        <property type="entry name" value="zf-C3HC3H_KANSL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KANL2-like probable zinc-finger" evidence="5">
        <location>
            <begin position="691"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="83"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="140"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="191"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="459"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="761"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="985"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="107"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="191"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="261"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="785"/>
            <end position="801"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAE1255675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1309" mass="140619" checksum="5595E01E4E6C6878" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C584</accession>
    <name>A0A812C584_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_28601</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001118">
        <property type="protein sequence ID" value="CAE1253771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C584"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1253771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="264" mass="31133" checksum="5E2B5C6AF2A7C522" modified="2021-09-29" version="1">MTSRTLFRGPSLHLSVISLPRFFPFVCELIFCIMKCYKTYLIFLSCLSISISSYLSISVCLYLFSYQAIYRSISACSHLSIYLSIYLSIYLSISVCSYLSIYLSQSAHIYLYLSIYLSIYLSIYLSIYFSLFISIYLSISIYLSIYLSIYLNKFISIYVSLFISIFLSSYLSIYLSLFTSIYLSQSVHIYLSTYLTQSISIYFSLFICIYLCLFISIHLSIFIISVFSYVSIYLIIFIFIYCYEFYLSARFKYKKKNLRKYLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C5H4</accession>
    <name>A0A812C5H4_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ABC-type glutathione-S-conjugate transporter</fullName>
            <ecNumber evidence="10">7.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SPHA_30475</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Farmed</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>leukotriene C4(in) + ATP + H2O = leukotriene C4(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38963"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57973"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:38964"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.3" evidence="10"/>
    <dbReference type="EMBL" id="CAHIKZ030001224">
        <property type="protein sequence ID" value="CAE1256838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C5H4"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015431">
        <property type="term" value="F:ABC-type glutathione S-conjugate transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18603">
        <property type="entry name" value="ABC_6TM_MRP1_2_3_6_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000001">
        <property type="entry name" value="ATP-binding cassette subfamily C member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000074">
        <property type="entry name" value="Multidrug resistance-associated protein 5 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF443">
        <property type="entry name" value="MULTIDRUG-RESISTANCE LIKE PROTEIN 1, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033065292" description="ABC-type glutathione-S-conjugate transporter" evidence="13">
        <location>
            <begin position="17"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="15">
        <location>
            <begin position="1"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="265"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAE1256838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="515" mass="57960" checksum="FFA884B68DA1A746" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C619</accession>
    <name>A0A812C619_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SPHA_29050</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001148">
        <property type="protein sequence ID" value="CAE1254573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C619"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="253"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="81"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAE1254573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="280" mass="32839" checksum="597AE2877900675F" modified="2021-09-29" version="1">MYLSPIYLFLSPQLFYSYLSIYLSIYLSISIYLSTNMNFFSSISYLCSLSIYHNLYHIHLSIHIYLSIYLSIYLSIYLSINNELFCLFISIYISIFLSILSIYPHSISIIYFTNMNCSGIYLSIICFISSIYLSIYQSIIYLSIHLSTNMNCSSNLFSIYLSLFISIYISIFLSIYHKLFISIYLSIYLSIYLSTNMNFFSYLSTYLSFFLSTTIYSYLSIYLSIYLSIYLSIYLSTNMNCSGNLSVCLSQSVYMYLSTYLSFYLPQSIHIYLSIYLSIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CAL4</accession>
    <name>A0A812CAL4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_31366</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001286">
        <property type="protein sequence ID" value="CAE1258759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CAL4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1258759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="181" mass="21777" checksum="32CC1FF51B6DA5CC" modified="2021-09-29" version="1">MALSKEFTHSFLFFLSIQHFRSFSFSPYYFVLRKFLSFFSFFFFLIRFLFSFFLFFFLFSFFLFSFFLFLISFISFLIHFPLLNTSKSVFFLSFFLSFFLLTIKKQIIHVCFSGLFKRKFMSSPFGGFDAIFRPILSTYSFYSNPLFFFHVSSSSFISFPLFPDLIPPLKNRAHFIPSKSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CDZ1</accession>
    <name>A0A812CDZ1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_33473</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001402">
        <property type="protein sequence ID" value="CAE1262961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CDZ1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1262961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="253" mass="29325" checksum="61DAB20BC4083640" modified="2021-09-29" version="1">MTNSFYSSASIVFSFIPSFLSFFNISFLISFLPLVRSYFTLLILSYILSTLPGIFHPQFLSFFFLSFFLSFFLFFLSFFSFILSLIPSFFYSFIQSYSSLSRLSFLPLPSQCFLSLINSFHSFINSFPFIFNFSFLPAFIPSAFTKFFLFSIHSFMPFLISTLCYYYSLCPSVRPSAHSFVRSFISQFSPFIPSFILSIIPSFLPSLIPYVFLAFPPTILYPFLSPRSSFYPLSLLIFQLLFILSYACLPCLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CEB3</accession>
    <name>A0A812CEB3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_33694</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <source>
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</entry>
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    </protein>
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</entry>
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</entry>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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            <authorList>
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    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1269965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="180" mass="21731" checksum="E2623A2C945C1A7C" modified="2021-09-29" version="1">MLKRRSTFILSVCSLFHNFTFIFIFLLFFFVFTLFFIFHRFSVFSSCSLFLLFHFLLSFSYCYSLPYSFSYSCLLFSLFIIPSLILFIILLFVFLLPFFISILSSIFFIFFLFFILLVRPFLIHLSLFVFRDYFVFTDFIPYQNIYFSSIVFKLFSFVFLFLLLAISSKSRLSKLLYDVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CIZ4</accession>
    <name>A0A812CIZ4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_35700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001546">
        <property type="protein sequence ID" value="CAE1267651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CIZ4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1267651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="313" mass="38023" checksum="341DF3DB3D9F34A3" modified="2021-09-29" version="1">MPSHFVRQKFGLKRRTDSHLSIYLSIYLSIYLSIPIHTYIHTYIHTYIHIYLSIYLSIYLSIYFTLLPLFLSLSQIYSVISSFFFFLFSYLFSRFIDFFASFFLSLFLSISELIHSLFLKYFSFFFPIFFHVLLIFLLLFFFLPFFLSFFLAISELIHSFSDPFFVSELIFFLFSYLFSRFIDFFASFFLSSFLSFFLSWYFRADPFFLFLNSFFSFFFPIFFLFFLSFSLIFFSLFLDLFVSFLLSFFFYYLTLHIIFISELLPFFIVFISQKLIFCLLLFIFFSLSSNCFFVSLFLFISVVIRSFFPSCYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CL79</accession>
    <name>A0A812CL79_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_37646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001680">
        <property type="protein sequence ID" value="CAE1272345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CL79"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1272345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="224" mass="26935" checksum="98056BF8DE33BFD7" modified="2021-09-29" version="1">MVTLSIYLSIYLSIQDAKHFLNFFSLFPLFSFSSFQALINSFFYFLIIIMNYFLLFFLLHLFLSFISCFLSFLSSFVSFFILIYLSFYIFVFSFTFFNFFLSVFLCLIYPSVNYFSFFLSFFLSFFLSFFLSFTLCYFYFFFTFSLFFGPPQVLLFFSTHPLPPLAFSIHSSLISLSSDYWHFFDIFHTISLQIKSYLPLQLLIHLLPPAKYRIISIHTRRYHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CQ53</accession>
    <name>A0A812CQ53_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_38007</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001716">
        <property type="protein sequence ID" value="CAE1273176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CQ53"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1273176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="223" mass="26399" checksum="599959FAEFDEF01A" modified="2021-09-29" version="1">MRHAVEEMFPNNINLLVSACSYLSIYLSIYLSIYLSIYLSMLVCSYLSLYAIFSISIYLCQFFQYLSIYLSIYLSIYLNTNFFNIYLSIYLSISMPVFSISIYLSIYLSIYASLFISISLCHFFNIYLCHFFQYLSIYLSIYLSIYLSIYLNVSFFNIYLSIYLSIYLSIYASLFISISLCHFFNIYLSMPVFSMPCLFNLSIYLSQNQIKIRENFSHLFINN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CR18</accession>
    <name>A0A812CR18_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_38506</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001749">
        <property type="protein sequence ID" value="CAE1273893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CR18"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1273893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="270" mass="31077" checksum="22FAEEFE03D2A725" modified="2021-09-29" version="1">MSGHVGILTPTLRCKCVHLKRHGFRFQNSSSTNPTPVLPLFASDPPPTRLAVVAASFPNLDSQRCPSQSSDGTDIDRKMGFRNWEKDRKTVSLRTESLRTQKLTSPTRTSRHQWILKFLPPPFFLHPHNRRRSIVFFVANYNTPVPFCLVSPPHLHLTSHKSCWLCHNHGTNPKGVGWHRRLTEKGSLLIFPASFPFVHLLLTASFFLASFFRAARPPFFPRNVVSIHLLIYWRNFNNESADFAVLVFIDGRFYFLFVHSFFLPSSFDPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CR59</accession>
    <name>A0A812CR59_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_41906</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002024">
        <property type="protein sequence ID" value="CAE1279718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CR59"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="287"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1279718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="321" mass="38645" checksum="C71A1D84FA6345F7" modified="2021-09-29" version="1">MHVCKIFFPPPTIPHIFHSLFFFFVPYCLPYFKSTYTCRILFYKSETSKKEKMCKSTQIFITGHSRRQLLLVSSSVLFTVIPSTLLFYLFFFLSFFLSFFLSFLLSFFLSFFLSFFSYFSFYLQISHSLFFFPSFRFFLSFFLSFFLSLFLSFFLSLHSFFFFPSFRFFLSFFLSLPVSLSIFHLVSLFPFFPFLLFLSFFLSFFLSFFLSFSFTFSLDIYFHSIFLSILFSLFVFFFSIAIFPLLLIFSLHDFSDDIFQIRFSPSPSWNALTNHLRLSLRIYPKANLFIIIIFYSFFLFFSSFFFLFIFLSFSIIVSFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CRA4</accession>
    <name>A0A812CRA4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_42005</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002032">
        <property type="protein sequence ID" value="CAE1279842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CRA4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1279842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="761" mass="79398" checksum="D2A340966C0C8E2F" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CSU3</accession>
    <name>A0A812CSU3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_41050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001962">
        <property type="protein sequence ID" value="CAE1278118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CSU3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1278118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="256" mass="31020" checksum="CAF6B71C2902AC18" modified="2021-09-29" version="1">MKKKKRKEENFCLLFSFSFNFFLSCFFIYPFTYIYTFLLNFIPRFLLPFYPFFRSIFYFCPSYPVFIPFFLPFTEVVFFHSFFLSFFLSFFLSFFSSFFLSFFTHSLIAIPSFYSSIFFLFLFPNTVCSPSCLPSFLLFFSNCLIFFLSFFLSFCCILRTLCRILFIHFIYPSFLSYTLSFIDPFIYLFFLSILSFILSFTFFLSFHSFYFIYPSFLSCELSFIETFFLSFFLSFFTHSLIAIPSFYSSIFFLVLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CT11</accession>
    <name>A0A812CT11_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SPHA_41167</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001971">
        <property type="protein sequence ID" value="CAE1278304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CT11"/>
    <dbReference type="OrthoDB" id="10254713at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036126">
        <property type="term" value="C:sperm flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007288">
        <property type="term" value="P:sperm axoneme assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042618">
        <property type="entry name" value="IQCG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14871">
        <property type="entry name" value="DYNEIN REGULATORY COMPLEX PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14871:SF1">
        <property type="entry name" value="DYNEIN REGULATORY COMPLEX PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAE1278304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="171" mass="20268" checksum="D1E367FAF13FF479" modified="2021-09-29" version="1">MKAKTIMESKYVNKCAEVGVAQTLKQRTLQEESHRKEIDSLEKHVDVETRVNAEIMQFLGKQQKNLVAKLDFWMEKHEKKDVEAKQLELDQLKASKNSDWERLLDLTRKYKEFEEVVVEDRIQKEIQRRKAEEEEMHLRASVKLSYLQLFLFIPFCFSLSLPTHSHDTNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CT34</accession>
    <name>A0A812CT34_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_41607</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002003">
        <property type="protein sequence ID" value="CAE1279074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CT34"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1279074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="243" mass="28839" checksum="7A771015DD7FF6C6" modified="2021-09-29" version="1">MRFCQSIYLSVSVPIELAIIPSIHPSISIYLSIYLSIYLSIYIILAIIPSISINLSIYLSLYRLIDIYLSIYLSITYLLTFMVSLSPFLYFFLSFFLSFFLSISLVFYLYISLFLYLYLSQSIYLHSFLSLFLSFFLSLYILYIYIYIYIYIYISVSIRFSLSLNLYLSIYLSLRLPDSSFVCLSDFVSHHIYLYLSNYLSIYQSIYLAITKYLSIYLSIYISIYLSIYLSIYLSRLICKWTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CUZ2</accession>
    <name>A0A812CUZ2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_40384</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001902">
        <property type="protein sequence ID" value="CAE1277013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CUZ2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13037">
        <property type="entry name" value="FORMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13037:SF24">
        <property type="entry name" value="POLYCOMB PROTEIN PCL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0945">Host-virus interaction</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1277013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="566" mass="63331" checksum="BF39839C3F352696" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CVU7</accession>
    <name>A0A812CVU7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_42490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002089">
        <property type="protein sequence ID" value="CAE1280768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CVU7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1280768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="161" mass="19604" checksum="C1A8B43E01EA4EF4" modified="2021-09-29" version="1">MHSVSHYLSFTLIQFIQSIYLSIYLSIYLSIYLSIVCMRVSIYLDIYIFSIHVCKRIYMYNFIYLFIYLSIYLSIYLSIYLSSFYLYLYIIYIYFYISLCITFHSSLYVSIIYAIYLSIYLYIYHKYYSISFFSSAPNLSIYLSIYLSIYLSIYLDRTHAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CXK4</accession>
    <name>A0A812CXK4_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF7041 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SPHA_42274</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002058">
        <property type="protein sequence ID" value="CAE1280348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CXK4"/>
    <dbReference type="OrthoDB" id="6262499at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055469">
        <property type="entry name" value="DUF7041"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23055">
        <property type="entry name" value="DUF7041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7041" evidence="6">
        <location>
            <begin position="39"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="151"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="209"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAE1280348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="221" mass="24964" checksum="B7913252CC503210" modified="2021-09-29" version="1">MSSHYYSLSTFSFPTSSSLLLVFSLSFLLFLSPPPVFLFFTPAWLLKLRARFANVMQKLPSDMMDEISDVLSDLCEHKPYNHLKEAILKRTGRSEEDMIQEILRNVTRGDKTLTQLLSFTTALTQFTPPTQQSPNATSGVRQNGRWRTCKDKYEKSRSPCTHEQGNRPRLDNIEEPPVENGEATRAFVGFLAHLAMEPGTADLPVHTRRLGETSKPEGGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D7Q5</accession>
    <name>A0A812D7Q5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_48768</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002740">
        <property type="protein sequence ID" value="CAE1291495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D7Q5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="325"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="353"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="382"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="416"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="451"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1291495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="487" mass="55204" checksum="20992F2CD7AAE7EE" modified="2021-09-29" version="1">MLVRSSLSSPGIFPQICNPMILESSSCLQMNHIRLPLSFIPLSPLSPLSPLSPFFFLLLCLLFLKCLLFSNFFFFLPLSPLCLLSPLCLLSPLCLLYPLCLLSPFFFFFLFSFSPLCLLFTLKVISLLLSFSLIFFLCLFLFFSSLSLSSYSSLSSFFLQLSSFSSLSSFPSSFSFFFCLLCPLCPLFVFFVFVSPFCLLCLLSPLCLLCSSFSSLSSFVFFLLFVFFVFFLLFVFFSSFFLIFFVFFSLLCLLCLLSSLSSLSSFLLFSFSFFSSFVLSSFSSLSYLSSFSSLSYLSSFSPLCLLFFSSLSPVFFFFSSFSSLFVFFLLFVFFSPLLSSFSSLSSFSSLSSFLLFFFFLSFLLCPFLFFVLFSSLSSFSSFVLFLFFVLFLFFVLSFSSLSSFSSLSSFSSLSPLSLLCFSFSSLFSFFLSSLFFSPLFLLLFSFSSFSSLFFFLLCLLCFFSPLCLLLFSFSSLSSLFLSPLCLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D9M7</accession>
    <name>A0A812D9M7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_48635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002722">
        <property type="protein sequence ID" value="CAE1291240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D9M7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1291240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="261" mass="29715" checksum="EBA04CA4618A8901" modified="2021-09-29" version="1">MPKLGNQARSTSESCQLSSLSDVNDIHEEPLRVRVHLSRSLDADVHIVKAVGDRRLVESDISSSGSSFLQSGSPKPQDMDLGAQLSLYQQHNCQVLQTFPPFSFSLSQYIELVGGGSWSTAGWENCRKPQQVDRCRTKIRLIYLFFRRNVILSIYLSIYLSISSVESIYLSIYLSIYLSMLLVILSIYLSIYLSIYLSIYLSLHISLLSFYLSLLILSLSLSLSLDLCLVILSIYLSIYLSIYLSIYYMRIGTFKQDDFNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DAF7</accession>
    <name>A0A812DAF7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_48813</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002744">
        <property type="protein sequence ID" value="CAE1291536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DAF7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1291536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="201" mass="24012" checksum="7B380A34D07AD9A4" modified="2021-09-29" version="1">MYLSKVSLMIRIFQILHCLLTTHPKLSLPIRYLIFLFIDLFSFLCFRFHHLHFSFSFFSIYSLPFSLSLSLFYSLPVFLSVIFSLSYSLFIHRFFLPGLEPLIPVKNKPETQSHERLFQLLFSFFLKFISVFRRFIIFCWFYYFLLVLLFSPGFSFFFNITSFLLLSISLSLLAFSSLSLFLANYHPLFIFLKIISFFLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DCR4</accession>
    <name>A0A812DCR4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_53880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003443">
        <property type="protein sequence ID" value="CAE1300413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DCR4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="307"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="338"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="373"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="402"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="431"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="460"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="488"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1300413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="531" mass="62664" checksum="661DA5B71D8F1588" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DG91</accession>
    <name>A0A812DG91_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PRSS12</fullName>
            <ecNumber evidence="6">3.4.21.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SPHA_51237</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="6"/>
    <dbReference type="EMBL" id="CAHIKZ030003093">
        <property type="protein sequence ID" value="CAE1296100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DG91"/>
    <dbReference type="OrthoDB" id="10066015at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000011">
        <property type="entry name" value="Scavenger receptor class A member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071:SF28">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRCR" evidence="5">
        <location>
            <begin position="35"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAE1296100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="156" mass="16929" checksum="EF3F864ACB85C75B" modified="2021-09-29" version="1">MVATQPEGQAAPRAGVNTLGSITPTSSTDQNAIRIQLVNGSSEISGRIEITRGGTIGSICDDEFDDNDAKVICRMMGYSTGEEIPNIFGDGEGVIWLDNLNCTGSEYGVEMCPNLSWGKHNCKHSEDVAIKCFKKGKYNLIISHKYTSNLNKKPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DGN4</accession>
    <name>A0A812DGN4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_51893</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003181">
        <property type="protein sequence ID" value="CAE1297260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DGN4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1297260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="171" mass="21176" checksum="BED2170ACF89C95F" modified="2021-09-29" version="1">MLFFLSLLLSFSSSFFFSFFFLFSSLSFFFFSSLLFSSPFPSLFFFFSSFSLLFLYFFSFFFFFLLFLFSFFFSFFFFFLLFSSFFFFLFLFSSLSFFFFLLFLFSSLFPSLFFFFSSFSLFSSFSLFLFFVLLFLYFFSFSSFSLFLLFFFFYFSSLLLFLLFFFPSYFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DH08</accession>
    <name>A0A812DH08_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_52774</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003325">
        <property type="protein sequence ID" value="CAE1298759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DH08"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134:SF22">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134">
        <property type="entry name" value="OS08G0543275 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1298759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="327" mass="37834" checksum="9CAB5648C9EC7C10" modified="2021-09-29" version="1">MDSKKLSKRNVHSSFISSVFIEESFLSFFLSFFLSFFLSFVLRLIIYLSIYLSIYLSIYLSIVLSFSVYLCIYLSIYPSFVLSIFLSFFLSFFLSFFLSQSSYLSVMECRALHLSITHQYYYSFVFSVCLSIYLSIYLSIDLNDLSVCSYLSIYLSIYLSIYLPVCSYLSLSLSLYLSIYLSVCSSLSLSLSLSLSLYPPVCSSLSLSLPIYLSIYLSIYLSIYLSVHLPLSMYLSTCLFIYLSIYLSIYLSIYIYIYIYVSVCLSVHIYISVYLSVHIYLSACLLISLYLSICLPVCSYICMYICMYVCMYLSIYLSIYLSIYLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DHN7</accession>
    <name>A0A812DHN7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">COL4A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SPHA_56952</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
            <location evidence="1">Basement membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003812">
        <property type="protein sequence ID" value="CAE1304336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10071882at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
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        <property type="term" value="C:basement membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:collagen trimer"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Collagen IV, non-collagenous"/>
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        <property type="entry name" value="Collagen"/>
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    </dbReference>
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        <property type="entry name" value="Collagen_IV_NC_sf"/>
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        <property type="entry name" value="COLLAGEN ALPHA-1(XXIII) CHAIN-LIKE ISOFORM X2"/>
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        <property type="entry name" value="SI:CH211-266K2.1"/>
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        <property type="entry name" value="C4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="11"/>
    </dbReference>
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        <property type="match status" value="2"/>
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        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="NC1_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
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        <location>
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            <end position="1715"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="9">
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    <feature type="region of interest" description="Disordered" evidence="9">
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            <begin position="215"/>
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        <source>
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        </source>
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        <source>
            <dbReference type="EMBL" id="CAE1304336.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1716" mass="170345" checksum="DB395F2E06D4EB52" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DIC1</accession>
    <name>A0A812DIC1_ACAPH</name>
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        <submittedName>
            <fullName evidence="3">CLIP3_4</fullName>
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    </protein>
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        <name evidence="3" type="ORF">SPHA_54721</name>
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        <name type="scientific">Acanthosepion pharaonis</name>
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        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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            <taxon>Decapodiformes</taxon>
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            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <location>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAE1301963.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="337" mass="36852" checksum="4A3BC4EDFFA4A2CF" modified="2021-09-29" version="1">MSREEEDDEIFQAENLVNCTPNPDCPMIHPCVDPPLCSNCQKSELSFFDPNCPGCQEILLRPTTAIPEIFAILRQWTPQTQQNIEVLINQILEKGANINDRDGLTDMTLLHYASKAGASGVGDAEMASRVVTMLIDKGADPFIRCRWTNMTALHYAAYFDVAPVIKILLKTTKAIDIDNTCSEFDHGSSLHIAASNVAYNAVKVLLQNGANPYMKDDLGRQPIDCVPDPKNFDEESEMAKLATKIRKMMPEAGPVSPNPCSPIFDPTQSRVTLQAMGLRLGDKVVINGSKSGALRYCGPTEFAAGIWAGIELDEKIGKNDGSVGGISYFRCAQNHGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DJD2</accession>
    <name>A0A812DJD2_ACAPH</name>
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        <recommendedName>
            <fullName evidence="2">Cytochrome oxidase subunit I profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_57109</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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            <taxon>Mollusca</taxon>
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            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
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            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003831">
        <property type="protein sequence ID" value="CAE1304510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Cyt_c_oxase-like_su1_dom"/>
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        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
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        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <end position="25"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DKJ3</accession>
    <name>A0A812DKJ3_ACAPH</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
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    <gene>
        <name evidence="3" type="ORF">SPHA_55339</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="8040188at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="260"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1303033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="308" mass="34214" checksum="52152684755215F0" modified="2021-09-29" version="1">MRLSQVALSDLFSQASQSKEERATFRASLRSRLKNAQRLKMNAQAAATTSASSSRARQSRDAAATARPRESEIELQRATRNSHNAAATSATRTSESPQSRANRLSWAATSMAAVRLSQTPQARRIRLDGDIQSLATARGITCPVYNLQAETRIGILPPSGRVPGRDVILLLQAMLHEVNSYIRSFKYSLENALFPSFSTVIDVDKWPHDEHERRYNAPACNEVAAIIHGDRVWTFFASSVTTKLATSFVIFILLSTSLFIYIMMTHLSIYLSIYLSIYLSIFLTDKTEDDKAEDFAQLAAVSFSGLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DM55</accession>
    <name>A0A812DM55_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_54797</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003603">
        <property type="protein sequence ID" value="CAE1302114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DM55"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1302114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="295" mass="31970" checksum="E017EA123775E36B" modified="2021-09-29" version="1">METVGFFGPAALICTGVVIVSLFSGRVPARWPVPRYIVAARRSFWMMIVIYAAAGTDPIIASDTIRALSSSLNRRRGSALSISIIRVAMMPHRCLPQCRTCGLRITSSARRRRPDAYTETMLHRAVRRLRAQACGPCTDPWRHGPSPQASWITPGRQHRPVSNPAVCLRQRDQNVPGRPLFEAAGIEEPASMAMPAMAAATQQAAVRTEGNPADWRLPASNSATVSPANRRTTGQLRAREPGRVCDKASNVPRSCLRLAAPASAPSSYSGFSPTSLQTASTSLRRRSSRSQSTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DQC7</accession>
    <name>A0A812DQC7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_60451</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004208">
        <property type="protein sequence ID" value="CAE1308594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DQC7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1308594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="404" mass="47077" checksum="5DA369E88ECBB0E1" modified="2021-09-29" version="1">MFEESLFEHCDWYQCSLFEPSFFDPFLWGQSAMYVDHPSSSIEDERESTTSEADPSLNIVHWRQSTMFEDNPSSNISAMYVDHPSSSIEDERESTTSEADPSLNIVHWRQSTMFEDNPSSNITILLRPLRTSENPNVRSRSFSEHCSLAPVDNVRRQPFFEHCDWYQCSLFEDRPSSTLFLWGQSAMYVDHPSSSIEDERESTTSEADPSLNIVHCSTMFEHLLTFRRPSFFDPFSLGPSAMYVDHPSSSIEDERNPQRRSRSFSEHCSLAPVDNVRRQPFFEHCYQSHFSKTVLLRPFSLGPVRNVLLTFRRPSFFDPFSLGQSTMYVDHPSSSIEDERRIHNVRSRSFSEHCSLAPVDNVRRQPFFEHCDWYQCSLFEDRPSSTLFSLGPVRNVRRPSFFVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DQH8</accession>
    <name>A0A812DQH8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_60519</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004213">
        <property type="protein sequence ID" value="CAE1308682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DQH8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="331"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="363"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="439"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="465"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="496"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="529"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="558"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="586"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="613"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="666"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1308682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="708" mass="84785" checksum="FEB8438F7C3F6D1C" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DSN6</accession>
    <name>A0A812DSN6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_59661</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004126">
        <property type="protein sequence ID" value="CAE1307629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DSN6"/>
    <dbReference type="OrthoDB" id="6282257at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38681:SF1">
        <property type="entry name" value="RETROVIRUS-RELATED POL POLYPROTEIN FROM TRANSPOSON 412-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38681">
        <property type="entry name" value="RETROVIRUS-RELATED POL POLYPROTEIN FROM TRANSPOSON 412-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="396"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1307629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="427" mass="48764" checksum="F63EA3D129DCACF0" modified="2021-09-29" version="1">MQKLPSDMMDEISDVLSDLREHEPYDHLKEAILKRTGRSEEDMIQEILRNVTRGDKTPSQLLRYMRNQLGKHNVSEKVLRAKHERYEPSKTERALADLQRQIQGAPDLPAPADEDIDPISTETNPSRERRSDQVFVGFIAHSAMGPGIVNLPVHTRRPGETNKPGESRRLTLPVPTRNVVYFTHIRRKDPYSEYRHATRFHWTFTVANVKVPILGADFLAHYALAVHMNPRTLSDTTTNLRVLGTPTRQGSTGISVATCHGREYLDLLTQFTDITLPLQVTASDVFKPTSPFVEELRHKMARQICNSATATGESYIPQHLRDCKFVFVRNDAVRRPLTPAYQGPFQVLRRTDKHLTIKRANSTDTIAIDRTKPAFLEKRQYDANPALRPLMLFQRTHQTQQTQHRRHQTTPQRLLCGRPDPVGGSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DTE9</accession>
    <name>A0A812DTE9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_60419</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004203">
        <property type="protein sequence ID" value="CAE1308555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DTE9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1308555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="228" mass="27075" checksum="6581FCEF56C9AF90" modified="2021-09-29" version="1">MAIIYLSIYLSIYLSIYLSILRLFKSIYLSIYLSIYLSIYLSIYLSSGCSNLSIYLSIYLSIYLSIYLSIYPHVQIYLSIYLSIYLSIYPQTVQIYLSIYLSIYLSILRLLKSIYLSILRLFKFIYLSTGEIRLTELTGFAWKQVTGHYLSIYLSIYLSIYLSKHDNWPLSIYLSIYLSIYLSIYLFVHTCRFTSFSSYRCSCHLFTYISYYTSTYLSLRNQKQPCNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DTQ4</accession>
    <name>A0A812DTQ4_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_60169</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004167">
        <property type="protein sequence ID" value="CAE1308271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DTQ4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032844904" description="NADH dehydrogenase subunit 2" evidence="2">
        <location>
            <begin position="19"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1308271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="253" mass="30267" checksum="9E6D9E27A1862723" modified="2021-09-29" version="1">MLFAELIWLTMILDPFLARPVNVCGVLIKVNIYLSIYLSIYLSIYLSISLIARYKETGPVHINISVHIYLSIYLSIYLSIYLSIYPSIFIYYSFVSLFVCLFLSIYLSIYLSIYLSISYKNGVFLFFFFLILSFLNNDLFLSFFLSFFLSFFLSFFLSFFFLHDVYFLSFFLSFFLSFFCFSFFLSFSPFILGFITLLSFFLSFFLSFFLSFFLSFLFFTKIVTFLSFFFFLSFFLSFFLFPRSYFKNNQITT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DVA8</accession>
    <name>A0A812DVA8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TBP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SPHA_62879</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004498">
        <property type="protein sequence ID" value="CAE1311447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DVA8"/>
    <dbReference type="OrthoDB" id="2127950at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04516">
        <property type="entry name" value="TBP_eukaryotes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000001">
        <property type="entry name" value="TATA-box-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000002">
        <property type="entry name" value="TATA-box-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000814">
        <property type="entry name" value="TBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030491">
        <property type="entry name" value="TBP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033710">
        <property type="entry name" value="TBP_eukaryotic"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10126">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00352">
        <property type="entry name" value="TBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00686">
        <property type="entry name" value="TIFACTORIID"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55945">
        <property type="entry name" value="TATA-box binding protein-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00351">
        <property type="entry name" value="TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAE1311447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="197" mass="21644" checksum="BABD49F629C5710F" modified="2021-09-29" version="1">MPPSNSSLYPQPTSATGGPMTPLTPATPASEGSGITPQLQNIVCTVNLSCKLDLKKIALHARNAEYNPKRFAAVIMRIRDPRTTALIFSSGKMVCTGAKSEEMAKLAARKYARIVQKLGFPAKFLDFKIQNMVGSCDVKFPIRLEGLVLTHQQFSSYEPELFPGLIYRMVKPRIVLLIFVSGKVVLTGMLSTHFLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DWI4</accession>
    <name>A0A812DWI4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_61149</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004302">
        <property type="protein sequence ID" value="CAE1309453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DWI4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1309453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="229" mass="25570" checksum="58523F4A96A1D18C" modified="2021-09-29" version="1">MMMFLIACPYCIHLEEQRFSYGQIYVACSRVGRGDDVFLIACPYCIPHTLRGAVLLIRPIYVACSRVGRGDDVFLIACPYCILHTLRFSLQPNYVACSIGRGDDVFLIACPWLPYTLRGAALLIRPNYVACSRRSSATHTPNLRSLLPSGRGDDVFLIACPYCIHLEEQRFIRPNYVACSRVGRDDDVFLIACPYMQGASLRGVHAFFIPPRGARSLLPNCGTPRVSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DWU9</accession>
    <name>A0A812DWU9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tubulointerstitial nephritis antigen-like,Tubulointerstitial nephritis antigen,Uncharacterized peptidase C1-like protein F26E4.3,Cathepsin B-like cysteine proteinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SPHA_62237</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Farmed</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004433">
        <property type="protein sequence ID" value="CAE1310708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DWU9"/>
    <dbReference type="OrthoDB" id="3789175at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02620">
        <property type="entry name" value="Peptidase_C1A_CathepsinB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="25"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="4">
        <location>
            <begin position="140"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAE1310708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="412" mass="47680" checksum="8B7BC02BE144D99F" modified="2021-09-29" version="1">MWVRGRIFSVPPHIYPHFMFLSPPIYLSILFFFSLSISIYLSIYLSIYLLLFIIYLSAVQIYLSLFTSIYLSIYLSIYLSLSFHYLSDVHIYLSLWRASNYSFLWGLTLSDGIKYRLGTFYPGEKVFGMQSLHPQKDESLPEYFDARQKWPGMITEIQDQRDCGSSWAFSTSAVASDRLAIGSSGDIRVKLSPQNLLSCVGIQSNNCTGGNIDQAWWYLRRFGAVTESCYPYKAREEACPFPRSGTPDTCPSGKYFKEHMTFKMTPPHRIQAHETEIMNQIYQNGPLQAIFTVKEDFYAYKSGIYRHTGASQSLPHIYQQTGYHSVRIIGWGVDIQPNGARTKYWLCANSWGTHWGENGYFRILRGEDECGIESFVISAWPRLPRRYHANRRARRHMDEKLISKLLFGSKKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DY53</accession>
    <name>A0A812DY53_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_64631</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004648">
        <property type="protein sequence ID" value="CAE1313524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6130269at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039878">
        <property type="entry name" value="RBM33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22014">
        <property type="entry name" value="RNA-BINDING PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22014:SF2">
        <property type="entry name" value="RNA-BINDING PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="1240"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="488"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="551"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="795"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="835"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="941"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1137"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="353"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="551"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="601"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="622"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="664"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="682"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="717"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="803"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="835"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1137"/>
            <end position="1152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1313524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1312" mass="145524" checksum="3479CD2EF67B828E" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E580</accession>
    <name>A0A812E580_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_68632</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005000">
        <property type="protein sequence ID" value="CAE1318097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E580"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1318097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="310" mass="36191" checksum="121AEF2CA560FD81" modified="2021-09-29" version="1">MQFARNILFQNLFIKILLISIYLSSLFIFIYLFNLLFVSIYLSIYLSIYLSLFISIYLSIYLSIYLSIYLSIYLFRSLLLNLSIYPSQSIFFLSHQSIIFISLTPQIFLFLYLSICLSIYSVHNYLVCSYLPLYRSIHLVFLYLSIYLSIYLSIYLSIYLICSYLCIYFVCSYLSIYLSIYLSIYLSIYLSILIFISLSLSCSLTLSLYLSLSINFLSFTSVHLIHISHFSDLSLSLSIYLSIYLSIYLSIYSYINGIKVNQITITFSVCLFLPQSLFLFLSQSLSHSVTITLSFFLLLSFCHNHSLFLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E7X1</accession>
    <name>A0A812E7X1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_68344</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004974">
        <property type="protein sequence ID" value="CAE1317826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E7X1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1317826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="224" mass="27127" checksum="63F4633F28391B47" modified="2021-09-29" version="1">MLIFKGGQSRLEKKELSCVTTQFSFFSFDFFPDEVFFFSHFFHNFHDIFNYLLFSFHHFSLIFFLSFFFFISLFYFSCFYIFFSPSVLLIFLLFFLSHIFSFFVNIFLLSLLSFPYFKLHFLFSSFSSFSLFQVIFSFFFFLFLLLISSYIFFFLLSLPSPYFKLHFLFSSFSSFSLFQVIFSFFFFFLSTFQVTFSSLSSFSSSFFFFKVTIFFFLLSLLPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EAF0</accession>
    <name>A0A812EAF0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MTMR14</fullName>
            <ecNumber evidence="2">3.1.3.64</ecNumber>
            <ecNumber evidence="2">3.1.3.95</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_71285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.64" evidence="2"/>
    <dbReference type="EC" id="3.1.3.95" evidence="2"/>
    <dbReference type="EMBL" id="CAHIKZ030005218">
        <property type="protein sequence ID" value="CAE1321137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EAF0"/>
    <dbReference type="OrthoDB" id="2408718at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052629">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004438">
        <property type="term" value="F:phosphatidylinositol-3-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039802">
        <property type="entry name" value="MTMR14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13524">
        <property type="entry name" value="MYOTUBULARIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13524:SF2">
        <property type="entry name" value="MYOTUBULARIN-RELATED PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="431"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="457"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1321137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="698" mass="79819" checksum="8521ADA248370C9D" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EBU9</accession>
    <name>A0A812EBU9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_70628</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005169">
        <property type="protein sequence ID" value="CAE1320323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EBU9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1320323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="306" mass="36629" checksum="2DEBEDD72AAF6ABB" modified="2021-09-29" version="1">MHHCTRYLSIYLSIYLCSYLFHSFPIYTTHLISIVVSSYLSIYLSIYLSIYLSIFIFIKLTFFISILSLNIYSSLFNIYLSIYLSIYLSIYLSHFVHIYLSIFFYQYQSLHIYTNHFISIYLSIYLSICHSYLSIYLSIYLSIYLSIYLSISFRSYAFISFHIHIRLFISIYLSIYLSIYLSIYLSIYLSHFSFQSIYLSIYLSIYLSIYLSIYLYIYIYIKTSNVFHCSNNSLCDNFTQYNIYTNHFISIYLSIYLSIYLSIYLSLFISIYLSIYLSIYLSIYLSIYLSIYLSIYLYGFVSCACV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ECH8</accession>
    <name>A0A812ECH8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_71000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005201">
        <property type="protein sequence ID" value="CAE1320790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ECH8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1320790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="222" mass="26168" checksum="16B1539CF91CE12B" modified="2021-09-29" version="1">MNLLSFFLSFFFLSFFLSFLLFFLSFFFSVKPAVLCYSVKYFLFRIFSFSLASVSLLFISFQQGRESQFSFSFLSMSHSFRSLDSLSLSLSLSLFCRFRFSTGILKVKTKTIYRYLFGWGDEDESDETLLSLIICPSDYITKSIYLSIYLSIYLSIYLSIYLILSIYLILLIYLSIYLSIYLSIYLSIYLILSIYLSIYLSIYLSIYLSIYLFIYLSIYLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EDV1</accession>
    <name>A0A812EDV1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SPHA_69504</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005083">
        <property type="protein sequence ID" value="CAE1319078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EDV1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="187"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="219"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAE1319078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="244" mass="28482" checksum="7CE15290836F8483" modified="2021-09-29" version="1">MFSFFFAGMKPTLPFPPPLSPPIPPPPPPPPPFPPTYPPFEPYPPFGPYPPFQPFATDPGMFNPQPGPDGYGILPFDIPPYPPFGEVNHPIPPIPSYDPFTFPPWNQYQRPIPNTLTGKYLHFFIRILPSSFLAFLFDFFFNVFIYLSIYLSIYLSIYLSMTVFSYLSIYLSIYLSMTVCSYLSIYLSIYLSIYLSMTVCSYLHLSIYLSIYLSIYLSIFIYFCLSFRLFFYYLFIFFYNFLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EH49</accession>
    <name>A0A812EH49_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_72281</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005305">
        <property type="protein sequence ID" value="CAE1322227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EH49"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="365"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="438"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1322227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="461" mass="51517" checksum="9FC88FBDD397CF5D" modified="2021-09-29" version="1">MILSLPLYIYLNHSFVCSFDLSYSLAPSLFLLNPHPQFFYLVNRFHCRNVRLTIGRWRRRCMLNRINNNNLSIYLSIYLSIYLSICCISPNILPSDIGSIFFQCHNIRTNFTNIVFCLSAIFLYSNILGRSIENIRLLLPSLIVSSFPASSSSSFWFCLFVEIRLLFSVIRLLLPSLIVSSSSSPASSSSSSSSSSSSSSSFSSSFSSYWFCLFVEIHLFLLSLIVSSSSSPASSSSSSSSSFWFCLFVEIRLLLPSLIVSSSSSPASSSSSSSSFSSFWFCLFVEIRLLFSIVSSSSSSSSFWFCLFVEIRLLFSIVSSSSSSSSFWFCLFVEIRLLFSIVSSSSSSSSSSSSSSFVFCCHLSLYLLLLLLLLLLLLLLLLLLLLLLLLLCFGFAHSLRFVFCFKLYFLLPLLLLLLLSFLPSFLPSFLPLSLPSLLTYFLSSFAIILHLLSPLFPLSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EJR8</accession>
    <name>A0A812EJR8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_72506</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005329">
        <property type="protein sequence ID" value="CAE1322562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EJR8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="91"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="152"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="301"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="335"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="795"/>
            <end position="816"/>
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            <begin position="822"/>
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        </location>
    </feature>
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        <location>
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        <location>
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            <end position="903"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="910"/>
            <end position="930"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1322562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="942" mass="114952" checksum="2404682330E7CF9E" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EJS6</accession>
    <name>A0A812EJS6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_73701</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005385">
        <property type="protein sequence ID" value="CAE1323880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EJS6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
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        </location>
    </feature>
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        </location>
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        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1323880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="350" mass="41900" checksum="604CAA40CA30E9AB" modified="2021-09-29" version="1">MIIYLSIYLSIYLSIYPTFLLLIYLSIYLSIYLSIYQSFCVNIYLSIYLSIYLSIYQFFHFVHIYFILHIYLSIYLSIYLSIYLSISVRSSQSVLSIYLSIYLSIYHSLFISIYLSINYLSQSVHIYLSIYLSIYLSIYQSFFVIIYRSIYLSISFSLFSHLFYSSYLSIYLSIYLSIYLSVVVYSFLSIYLFIVVSSFLSIAVYSFLSIYLSIYLSIYLSIYLSIYLFFFLLFFFFLSFFFLFFFLSFSLFSVHFYLSIYLSIYLSIYLSIYLSQSVHFYLSIYLSIYLSITSVNYLSMYQSICSYLSVHIYLSLFISIYLSIYLSIYLSIYLSICSYLFTYLSFYLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EMG4</accession>
    <name>A0A812EMG4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_73843</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="CAE1324130.1"/>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EMG4"/>
    <dbReference type="Proteomes" id="UP000597762">
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    <dbReference type="PANTHER" id="PTHR45134:SF22">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
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        <property type="entry name" value="OS08G0543275 PROTEIN"/>
        <property type="match status" value="1"/>
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            <begin position="20"/>
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            <begin position="82"/>
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            <end position="299"/>
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        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1324130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="340" mass="40701" checksum="D2F366C448FE6622" modified="2021-09-29" version="1">MYVSIYLSLFISSIYPSIYLSIYLSIYLSIYLRLLMVYLCMYLSISTINGVFMYVSIYLSLFISIYLSIYLSIYLSKTINDVFMYVSIYLSLFISIYLSIYLSIYLSIYLSIYLRLLMMYLCMYLSISVYSYLSIYLSIYLSIYLSIYLRLLMVYLCMYLSISSIHLSIYLSIYLSIYLSIYLRLLMVYLCMYLSISSIHIYLSIYLSIYLSIYHLSIYLRLLMVYLCMYLSISVYSYLSIYLSIYLYLSIYLSIYLRLLMVYLCMYLSISTINDVFMYVSIYLSLFISIYLSIYLSIYLSIYLRLLMMYLCMYLSISVYSYLSIYLSIYLSIYLSIYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EN45</accession>
    <name>A0A812EN45_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_75622</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005466">
        <property type="protein sequence ID" value="CAE1326056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EN45"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="176"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="245"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="282"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="305"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1326056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="381" mass="44399" checksum="19FF6C1A734B44E8" modified="2021-09-29" version="1">MPPLPRLRQGSTSFVATDTGKHGWRRSSSPPPSHRRVRPSNAVVMLLVETPGRRMSPAVVTAVTFAGSCHTFGLLLTGLFSTQFLDVQSPSRRSRIELPPSACSFRVSWLLSYASGKQIDGPRTWVAGHLAKLCPTKKPASKENQAPVPTPVVPAEEGKNYFLYLFFPPVFHIDPFFFLCASLFAIFFFAFFLPAFILNYLFFSFFFFLKSTAWGFNFIFVPFFIYFTLSFYFRRSLVSMFYFNFLLPFFFCFFHSFYFSFFFFLSSFLLFQLYMIIVSNQFTLVIILFSIYFFLYFFFLLMNSTSAVCISFSSFSTLLILSSSDLLFLHHFISSFVFFLNDIICFYFSYYNLLNIYKIIFLMFIICLFLSFSLSHQIFFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ENP1</accession>
    <name>A0A812ENP1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_75970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005478">
        <property type="protein sequence ID" value="CAE1326398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ENP1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1326398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="382" mass="41083" checksum="534FFABB067E8AA3" modified="2021-09-29" version="1">MIANSKESIQYLEISFFHPLPSPHLLVLTSLFLLVCPHLLVLTSFFLLVCPHLLVLTSLFLLVCPLFLVPTCLSSLACPHFLVPTCLSSLACPHFLVPTCLSSLACPHFIFPTCLSSLPCSFMFVLTSLFLLACPHLLVLTSLFLLVCPHFLVPTCLSSLACPHFLVPTCLSSLACPHFLVLTCLSSLVCPHFLVPTCLSSLACPHFLVPTCLSSLACPHFLVPTCLSSLACPHFLVPTCLSSLACPHFLVPTCLSSLACPHFLVPTCLSSLACPHFLVPTCLPSLACPHFLVPSCLSSLPCSYLFVLSCLYPLPCPHLLVLTSLFLFACPLLLVPTSLSPLACPNLLVLTCLFQLACPDLLVLTCLSSLACPDLLVPTCLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EQ69</accession>
    <name>A0A812EQ69_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_80018</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005588">
        <property type="protein sequence ID" value="CAE1330741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EQ69"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="311"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="350"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1330741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="377" mass="45518" checksum="E4A7A75D3AB110A3" modified="2021-09-29" version="1">MSVICLHYLSIYLSIYLSIYLSIYNLFQSIYLSIYLSIYLSICHTFYVVANMLDNVSFLFSLRFFFFFSFFHSFTVFFQFFLSIFLLFISFFLAFSFFTPIFLSFFFSLFLSRFSFLLFISSFLLCCFFSFFLSLILTFLLLISYSCFLFLLLCLSSCFLHSFFCSFTFFLLVFFHCLPFFFSFFFLAFVYFCLAFPFFLSFFLSFFLSFLLSGFPFIHSFFLPFSNFLSFFLSFFLFFFLFIAFPFFLHLFHVFAFFLSFPSFHSFFLACFSSISFTFLSFFLCWLSILSFSLFLSCILFSYIPFFPCRCFFLFPVFLAFPFSSFPLFLPPFLHFFLCFFIAFPSFLSFFFFFLSFFFGFPFFLFLFLSCFLSLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EQN9</accession>
    <name>A0A812EQN9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_76838</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005498">
        <property type="protein sequence ID" value="CAE1327313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EQN9"/>
    <dbReference type="OrthoDB" id="8963674at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="248"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="297"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="349"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="390"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1327313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="445" mass="51306" checksum="806E7A12C5C07C6A" modified="2021-09-29" version="1">MSRHGRTSIISTLHTTLFSYIYFSLSFFSLSLSLSLSLSLSLLVVNFNFNLSIYLSIYLSIYLSVCLSISVLALSIYLSIYLSIYLSISSVYFLSIYLSIYLSIYLSIYLNQFIFYLSIYLSIYLSIYLSQFIFYLSIYLSIYLSQFIFYLSIYLSIYLSISLSIYLNQFIFYLSISIYLSVHFLSIYLSIYLFDSFSIYLSIYLSIYLSQFIFYLSIYLSIYLFISLFSIYLNLVLSIYLSIYLNQFIFYLSIYLSIYLFIAISSDQYWGIPPISIYLSIYLNIYLTLYLSQPVDILHLSIYLSIYLSIYLSQYLQNSLFICGQSASIYLSIYLSSSDANINPYNTSHLTIFVLSLFLSFFLFSLPVSISLLHPTFSFVPSPLPPPRLSSSSSSSSSSSSSSSSSSFSSSSSFKKSSQNMAFLVDKNLSNEKQTKKKATRRKCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ERM8</accession>
    <name>A0A812ERM8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_76235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005486">
        <property type="protein sequence ID" value="CAE1326663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ERM8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1326663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="295" mass="34268" checksum="892C96F35B9B2D81" modified="2021-09-29" version="1">MLKRIRVDSSSIILQAIWLSTKAVNTSHVESQSRFSPYLSVHPLISFIFFSFSLSFLDFNNVLNLFSLCSYLSIYLSIYLSIYLSTSAILRMKNRSFYTTNTSQNIYLSIYLSIYLSIYLSIYLSITHAVSFDVFRYHKLYIYLSIYLSIYLSIYLSIYLNTQSCQEIPDLNVLTCDCFSLFLVVACFFFSHFVTPLLVLSCFFPCTFSLFFLVFFPFSRDVSLSLILSYFFLSFYSTVSRFVSNFSLFFFFDFLLFIFSASFSLLLFSCLFSLPVRIAVFIAEPLPLPPTSSFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ERZ0</accession>
    <name>A0A812ERZ0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_78514</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005542">
        <property type="protein sequence ID" value="CAE1328883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ERZ0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1328883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="318" mass="38176" checksum="2195727F326E57C2" modified="2021-09-29" version="1">MSIYLSHFVSIYLSIYLSIYLSIYLSISKPRALQSGRILKISFSNNVNFLIVFFIYRNQSIYLSIYLSIYLSIYLSLSFHIYLSIYLSISFCFYLSMYLSIFPHWSYSFLPSFLPSFLSIYLSIYLSIYLSIYLSKFIHISLFTSAYSYLSIYLSIYLSIYLSLFISLSIYLFISVCSYLSISGLLSFFLSFFLSFFLLSFFLSFILSSVFYKSISLFFLSFFLSFLFFLTEITFFLSFFLSYYLIFPYRDYFLSFFLSFFSFHYYLLFLTEPSFFLSFHYINFPYRTFFLLIFLLFLSGPSFFLSFFLSFFLSFFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ESW0</accession>
    <name>A0A812ESW0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_80328</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005597">
        <property type="protein sequence ID" value="CAE1331048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ESW0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1331048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="198" mass="23067" checksum="2531BFA4A2CB67A6" modified="2021-09-29" version="1">MYLYLSFFFSPSSSHYLSIYLSIYLSASDHSYGNHFLTPSVRILIFLYLPLLFFSFFSLSFSHYLYIYFYMYLTSLFSHSFFLSLSLSLSLCLLLFICLPISIYLSIYLSIYLRLYKYNFQLSVPSHYHRLASLSLSLSLSLSLSLSLSLSLSYSLACCLPALFQFFHRSVTENVRPQEGSICLFKICKSPQFIFTRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EYA1</accession>
    <name>A0A812EYA1_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">SPHA_79906</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Farmed</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TMTC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="5"/>
    <dbReference type="EMBL" id="CAHIKZ030005582">
        <property type="protein sequence ID" value="CAE1330633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EYA1"/>
    <dbReference type="OrthoDB" id="19588at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052346">
        <property type="entry name" value="O-mannosyl-transferase_TMTC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013618">
        <property type="entry name" value="TMTC_DUF1736"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44227">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44227:SF3">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE TMTC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08409">
        <property type="entry name" value="TMTC_DUF1736"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="17" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 13" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="6 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="327"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="403"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="429"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="454"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1736" evidence="16">
        <location>
            <begin position="309"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="13">
        <location>
            <begin position="499"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="13">
        <location>
            <begin position="533"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="13">
        <location>
            <begin position="567"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="13">
        <location>
            <begin position="601"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="13">
        <location>
            <begin position="669"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="13">
        <location>
            <begin position="703"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="532"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAE1330633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="754" mass="85869" checksum="8AEB500597D52542" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AI30</accession>
    <name>A0A812AI30_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_643</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000014">
        <property type="protein sequence ID" value="CAE1140624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AI30"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="345"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1140624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="416" mass="47215" checksum="7A7634BBCB9FB9EB" modified="2021-09-29" version="1">MNPANVGRQACNDISLFPPILLFHLSLSTSHSFHLSLFPPLSFDLSLFPPFFLSISLSFQLSLSFDLSLFPPLIPPISLSTPLSFHPSHSSPLSLSTSVSLSTSFSLSTSLSTYLSFHLSLIPPLSLFPRISLFTSHYFHLSFFPFHFLSISLSLFPPISLSSYLSFHLSLSFHLSLSFHLSFHLSFFPPISHSTSLSLSPYLSIHLSLFPPLSLFPPLSLFPPIFLSTSLSFQLSLFLRISLFISHYFHLSFFPFHFLSNSLSLSFHLSLFPPLFPPISISTSLSTYLYFHLSFHLSLFPPLFPPLSLSTSLTLFTSLSFHLCLSFHLSFHLSFFPPLSHSTSLFLRISLFTSLYFHLSFFLSFFLSFFLSFFLSFHLTFFPTLSLFTYLYFHLSFHLSLNSPLSFHSLSLLPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ATG4</accession>
    <name>A0A812ATG4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DNMBP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SPHA_4714</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000153">
        <property type="protein sequence ID" value="CAE1156300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6244550at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14686">
        <property type="entry name" value="bZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051492">
        <property type="entry name" value="Dynamin-Rho_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22834">
        <property type="entry name" value="NUCLEAR FUSION PROTEIN FUS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22834:SF20">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00499">
        <property type="entry name" value="P67PHOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="13"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="77"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="150"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="256"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="346"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="7">
        <location>
            <begin position="845"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="domain" description="BAR" evidence="8">
        <location>
            <begin position="1042"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="1485"/>
            <end position="1548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="469"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="536"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="576"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="763"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="475"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="514"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="576"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="690"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="711"/>
            <end position="727"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAE1156300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1551" mass="173989" checksum="48B7956B9D10509A" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AV41</accession>
    <name>A0A812AV41_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_4744</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000154">
        <property type="protein sequence ID" value="CAE1156358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AV41"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1156358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="233" mass="27776" checksum="349AD70A6F3EE79B" modified="2021-09-29" version="1">MISIYLSIYLSIYLSIYLSIYHDMFIIYLSIYLSIYLSIYLSRYVYYLSLSLSIFYNMFIIYLSITICLLSISLYIYIYIYIYIYIYIYHGMFTISPSLSLSLSIYLSIYLSRYVYYLSISLYIYLYITVCLLSIYLSIYLSIYLSIYLSIYLSRYVYLSITICLLSLSLSIYLSITICLSIYLSIYLSIYLSIYYDMFVIYLSIYLSIYLSIMQMISVTSTVMKTVHFVSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AWX1</accession>
    <name>A0A812AWX1_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7041 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_6614</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000215">
        <property type="protein sequence ID" value="CAE1160846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AWX1"/>
    <dbReference type="OrthoDB" id="10066870at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055469">
        <property type="entry name" value="DUF7041"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053134">
        <property type="entry name" value="RNA-dir_DNA_polymerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559:SF444">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559">
        <property type="entry name" value="TRANSPOSON TY3-I GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23055">
        <property type="entry name" value="DUF7041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7041" evidence="2">
        <location>
            <begin position="18"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="112"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1160846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="377" mass="41952" checksum="78F8C2279F0B7438" modified="2021-09-29" version="1">MDEEKTAVVSAVNTVSLAYFKADPALFFAQLESECELRGITSQKTKFNLAVSKLPLEAVQEHLPSAYHAVLAAVGEDAPVEKLAEIADNVADLTSGCTAPVSAVQTQEPDPLAKLLEGQRRLEARMEDLERRLQKVSIHRSQSRGRAVNKSLIQTYGQRCLTLNLGLRRVFTHFFVLVDVEKAILSADFLHKFGLLIDVHRRCLTDPKTNTHSPGAIHNVIPSCPTVANTEDNPMFCELLKKFESITKPAFRKDRLPHNITHHIATSGPPVHSRPRRLAPEKLSVAKAEFTQMMELGIIRPSKSNWASPLHLVPKSGGTWRACGDYRALNSATKPNHYPIPHIHDVTAIIQDSYPFLHRTSSSCISIYLSIYLSIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AY71</accession>
    <name>A0A812AY71_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_9229</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000294">
        <property type="protein sequence ID" value="CAE1167004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AY71"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1167004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="266" mass="33439" checksum="89320E13F1B75E5A" modified="2021-09-29" version="1">MSSLFNIRTQAAEMIDRLRMNGYIRETLLSFFLSFFFFLSFFFFFLYFFLFFFFLFFFSFFFFFLFFFFFLSFIFLSFLFFSFSFFFFLFFSFSFLSFFFFLFSFLSFFFLFSFFLSFFSFFPFFFFLSFFLSFFYFFSFFFFFLFFFFFSFFLFSFFLFSFFLSFFLFFFLSLRSYNVLNCVHSFNHSVSFSFSALFILLPIPFFLFLFRFLSLFFFFFSFFLIPSCPIMSQTVFILSLILFFSIYLSIYLSIYLSIYLSIYIYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B4G6</accession>
    <name>A0A812B4G6_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_10500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000338">
        <property type="protein sequence ID" value="CAE1169214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B4G6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033031530" description="NADH dehydrogenase subunit 2" evidence="2">
        <location>
            <begin position="20"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1169214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="256" mass="30737" checksum="F4EFB1A2E42CF5E3" modified="2021-09-29" version="1">MASLSLFLSLSLFLSLSLSFSLNVSLLELSFFFILHSYHFCDIYLFLHYFLLLHCYNFCDIYSFFLSFFFLSFFLSFFCSILIISFIYIFFIFISFYFIYSILIISLLHIFFLSFFFSFFFLYLFHSLLYSILIISVIQIFFLSFFLFFFLLLYFLLILLSFEFRPSSLGWWGVSPSEFCSWYSFLTFPSNIFFSNHYLSILAVFLQKSIYLSIYLSISFYTNLSICTYVHLYLSIYLSIYLSIYLSIFVSLYASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B563</accession>
    <name>A0A812B563_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_10056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000322">
        <property type="protein sequence ID" value="CAE1168451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B563"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="290"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="324"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="380"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="440"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="470"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="498"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1168451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="587" mass="69925" checksum="C9FFD848E15A7FCC" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B6J0</accession>
    <name>A0A812B6J0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_11118</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000365">
        <property type="protein sequence ID" value="CAE1170491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B6J0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1170491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="267" mass="30997" checksum="D00C10EEBD6CAD33" modified="2021-09-29" version="1">MSFYSYLSIYLSIYLSIYLSIYLSISFYSYLSIYLSIYLILFISFNRSMSTSSLSIFLYATSSLPNHLSLSLSLFPSIYFILFISIYLSIYLSIYLSMSTSSLSIFLYATSSLLTPLSLSLCLSIYLFHSIHIYLSIYLSIYLSIYHILFIIYRSISIFPFLFSLFLALYFLFLFFFLLFLFHLASVYQSIFLISLTSHDLFLLSFVHIYLSLSLILSFLSLSPTPSPPPSLSFSHFLPHSFSLEYIFGDHDHFTLLSAHFKQTNSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B842</accession>
    <name>A0A812B842_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_12701</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000424">
        <property type="protein sequence ID" value="CAE1173535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B842"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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            <end position="31"/>
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            <end position="143"/>
        </location>
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            <end position="172"/>
        </location>
    </feature>
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        <location>
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            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1173535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="255" mass="31030" checksum="AB6A6488330F5655" modified="2021-09-29" version="1">MYHFTYQALAFLFFLHPLSSFFLSFFLSFFLSFFPHRAFFLVAFLFFFVSIFYQRPSLKFFLSFFLSFFLSFFLSFFLSSFLSFFLSFFFPSLSFFSFSALTLLFFLLILSTVHPFSFFLRFLFLFSFFLSFFLSFFLSFFLFYFCSSIFLSFFLSFFLSFFLSLFLSVFLLSVFLSFFYYFLLSFSPFFLSFFSIYSAFIPFFLSSFFLSCLSFLFFINCLLSFFLFLFMLSFTFLLLKSFFLSFLLSFVYYIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B8L6</accession>
    <name>A0A812B8L6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_11781</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000391">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B8L6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
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            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="175"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1171816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="227" mass="26982" checksum="43145DAEE7978D06" modified="2021-09-29" version="1">MFFLPPPFYICIISSSSPIYTHHLFLNSHYPTNPAFILHLSAFYQNQLPVIDLARWKCKGKSLSFDDTESFLRNIFLSIYLSISIYLSIYLYSLSIYLSIYLSIYLSMFVIFLTLFILFIYLCPFYLSIYLSIYLSIYQSIYLSVCMFIIFLILFYLLFIYVYKNNEKVHFIYLSIYLSIYLSIYLSIYLSVCLSLSVHYISYSGHTIYLSIYLLSIYLSIYLSIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BDR5</accession>
    <name>A0A812BDR5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_15521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000540">
        <property type="protein sequence ID" value="CAE1224827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BDR5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    </feature>
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        </location>
    </feature>
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            <end position="778"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
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        </source>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="809" mass="85421" checksum="F9A5B2D4C1F66E9D" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BJ13</accession>
    <name>A0A812BJ13_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">SPHA_21308</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
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            <taxon>Sepiidae</taxon>
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        </lineage>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000780">
        <property type="protein sequence ID" value="CAE1238336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BJ13"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="731"/>
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        </location>
    </feature>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="759" mass="88100" checksum="4B592F5AAD5493ED" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BJ42</accession>
    <name>A0A812BJ42_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_16504</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Spiralia</taxon>
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            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000581">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BJ42"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1227739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="162" mass="18567" checksum="31BE07E3231A4B4A" modified="2021-09-29" version="1">MVYPLPPPSDRTVRIKLHPKVFLSPVRLLFVNQPALYLSIYLSIYLSIYLSIYLSIPVCSYLSSYLSIYIYLSIYLSIYLSIYLSIYHVHRHTKTHFLFFSPSISLILSFIRSLSLSLSLSLSLSLSFSLCGVRICLRKTLSHIVTKAAEIIPRNHGRPYCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BJW2</accession>
    <name>A0A812BJW2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SLC26A1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SPHA_18973</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000686">
        <property type="protein sequence ID" value="CAE1233518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BJW2"/>
    <dbReference type="OrthoDB" id="288203at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SpoIIaa-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="6">
        <location>
            <begin position="131"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAE1233518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="286" mass="31545" checksum="98BE9944C181D46F" modified="2021-09-29" version="1">MLFSRDICTSIYLSIYLSIYQELYAYGITNIVISFFGCFTATGAVSRTSVQVGCGAKSQVSSLVGALFVLIVIFVAGPWLKTLPICVLSFGIGLLIGAVLGIISVIMRTLWVEAVSLGIINNTKVFLDQTKYQGVTLPAGIKVVSYSSPLYYANVDIFRNEIDSKTEKFKKVNKHSNGQMVSTDLSIIINPKSANSLHEDRFHQKIIIECSGISFIDRMGATALQQLYVEYKNKGISCLFSGVNDRVISVLKACGAFNTLQYVMYRTTYDAMLAAGFEENEINTRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BKF0</accession>
    <name>A0A812BKF0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_19271</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000700">
        <property type="protein sequence ID" value="CAE1234221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="324"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="384"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="420"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="448"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="476"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="506"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="537"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="569"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="597"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="629"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="661"/>
            <end position="684"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="712"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="750"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="857"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="890"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="919"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="952"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="993"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1017"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1042"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1119"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1144"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1169"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1200"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1237"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1280"/>
            <end position="1299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1311"/>
            <end position="1332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1344"/>
            <end position="1361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1234221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1384" mass="164133" checksum="DE887BF7230F87E8" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BLG6</accession>
    <name>A0A812BLG6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_19527</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000708">
        <property type="protein sequence ID" value="CAE1234811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BLG6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1234811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="226" mass="25761" checksum="D475E471B4DE459C" modified="2021-09-29" version="1">MASSDILFQTFSSFSLLQPPSSCNSLLPLFSCSSLLPPSSYCNVLPLFSYSNLLPPFFYCNSLPPIAVCFLFPPITEYAFFSRNLLPSVSCSSLLPPVSYSMQLPSFHSNLLPLFSHSILVSPLIFYSLSLLWQCAFFSCNLLPRFSYSNLHACFFYSTAFSFTNLLPFFSSSNHISSLLFFSLFDVFSLFLLSFGLEFPLRSFLFLFSYKCLFLRSFLSFFFSVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BME8</accession>
    <name>A0A812BME8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_20410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000747">
        <property type="protein sequence ID" value="CAE1236774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BME8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1236774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="168" mass="18950" checksum="68217C9C640FB8F0" modified="2021-09-29" version="1">MQANNLVIVSNFVFRYRAVEKIFENLCLDIFSTFISFHSIAVFFEDSFIYNSFSGHFILLTFPLVDSLCLSVFLSLSLSLSNALFLSFSISQSFSRSVALFLLFSLSLSRSLYRSLSFFFSLSIAVFLSFFSLSLSLSIAFFLFSLSSAFSLSLPLSLSISRTCFNLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BN53</accession>
    <name>A0A812BN53_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase A2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_20440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000748">
        <property type="protein sequence ID" value="CAE1236832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BN53"/>
    <dbReference type="OrthoDB" id="6932368at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001995">
        <property type="entry name" value="Peptidase_A2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50175">
        <property type="entry name" value="ASP_PROT_RETROV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A2" evidence="2">
        <location>
            <begin position="41"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1236832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="154" mass="17674" checksum="FF0937851229FDEA" modified="2021-09-29" version="1">MTQLRAELRDLKLSLCRRSPAPRTRNRSRTIAQVQDGETVWTNVVDTGAAISVIPPTNRSALKPTSFQLRAANGSTIETYGTKELTLNINLRRDFKWSFTVADVKTPLLGADFLAHYNLAVHMKTWRVLVFIWTAIRQHDIHQDHRDPFELQHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BPV3</accession>
    <name>A0A812BPV3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DIP2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SPHA_20671</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Farmed</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat WDR3/UTP12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000759">
        <property type="protein sequence ID" value="CAE1237283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BPV3"/>
    <dbReference type="OrthoDB" id="407922at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000157">
        <property type="entry name" value="WD repeat domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007148">
        <property type="entry name" value="SSU_processome_Utp12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051570">
        <property type="entry name" value="TBC1_cilium_biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19853">
        <property type="entry name" value="WD REPEAT CONTAINING PROTEIN 3 WDR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19853:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25173">
        <property type="entry name" value="Beta-prop_WDR3_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25172">
        <property type="entry name" value="Beta-prop_WDR3_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04003">
        <property type="entry name" value="Utp12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="71"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="113"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="155"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="197"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="484"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="582"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="624"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="666"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="domain" description="Small-subunit processome Utp12" evidence="6">
        <location>
            <begin position="790"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAE1237283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="905" mass="102434" checksum="93D0FDBAFACFCDD4" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BRJ9</accession>
    <name>A0A812BRJ9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_25611</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000968">
        <property type="protein sequence ID" value="CAE1247231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BRJ9"/>
    <dbReference type="OrthoDB" id="10569444at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1247231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="199" mass="22630" checksum="A808AB9E7B85B0E9" modified="2021-09-29" version="1">MDHSLVSCKVRLTAKKIHHSKTKGLPCINTCHSNDPETSRRFQTIFSAKVNTSSLSATDIDSRWHHLHDAIYTSALTAFRKKYRQNANWYTAHWDEMQPVSKAKRQALLTYKQNPCISTRDAIRAAHSKAQQTARHCANNYWRNLYSMIEMAANSGNARGLYAGIKTTPSPTPIKTTPLKSKALEITDQGKQLKHWVEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BS01</accession>
    <name>A0A812BS01_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_21780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000802">
        <property type="protein sequence ID" value="CAE1239466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BS01"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="284"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1239466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="322" mass="37521" checksum="985E3AA7FBE3554A" modified="2021-09-29" version="1">MHACMCVSIYLSIYLFIYLSIYLSIHLSIHSYLSIVVHPHPSISSIYLSIYLSIYLLNSIPYSIPYLSIYLYLSIYPSIYLLNPFLLCMYACMHVCIYSSIYLSIYLSIYLSIYLFIYCSPFPYLSIHLSIYLSIYLSISLNPFLMYVCMHACMCASIYLSIHPSIHPSIHHSCMYCSPFPIYPSIYPSIYLSIHLSIYLSIEPIPYVCMYACMHVYLSIYLSIYLSIYLSIYPLNPFPCMYVCMHACIHLSIYLSIYHLSSIISIIHSVLLIYLSIYLSIYSFIYLSIEPIVCMYVCMHACVYLSIYPSIHPSIYPYLSIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BWU0</accession>
    <name>A0A812BWU0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_24295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000905">
        <property type="protein sequence ID" value="CAE1244443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BWU0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1244443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="236" mass="29980" checksum="0D353FFFB9701F3D" modified="2021-09-29" version="1">MNFFLSFFSFFFLFLFYELLFFFFLSFFLSFLSFKKVSFFFFSFSFFLSFFSLFLCYFFFFFLSFLFFSYSYVMNCLLSFFLSFSLSYVPQTVFFLFFFFFFYSYVFFFLSFFFFFLFFPSFFFFLFLYSYVMNCLLSFFLSFFLYFLFLSFFSFFFLFFLFSFLFSFFLFFLMLFSSFFFSFFLFSFLCFFLLSFFLSFSFLCYELFSFFFFLLFSLSFFLSFFFLSFFFSLFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BZ25</accession>
    <name>A0A812BZ25_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_25307</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000957">
        <property type="protein sequence ID" value="CAE1246738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BZ25"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1246738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="207" mass="25566" checksum="3FB34EE51AD53432" modified="2021-09-29" version="1">MLHTVSFFTWSLAPNTLAPWSNLRRQYVRWTISDWVQFRGNGKSGGDVIKCFFVCRTKRSLFSLNVFFLSFFFFFLSFFLSFFSFFLHFFLSFFFFLCFFFFLFLCNFFLFSFFFLSFLSFFLSFSLQLFFFFFFSFFFFSVTFLLRNFSFFFLSFFFLSFFFLCNFPSSQFSFFFLSFFFLSFFFLCNFPSSQFSFFFLSFFLFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C0U6</accession>
    <name>A0A812C0U6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_30373</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001223">
        <property type="protein sequence ID" value="CAE1256798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C0U6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1256798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="201" mass="24303" checksum="2B7178D250CD0D1D" modified="2021-09-29" version="1">MFPRCLFKRQTPQTDSSTLHPCLVYRTVRLSAILMNINAFYFLYPNGFIDPISTLSIYLSISVCSYLNQSIPIYLSIYLSIYLSIYLSRAVHYLSIYLSIYLSISVFSYLSIYLSIYLSIYLSSFIHSFIFQFHYIFFFLFRTFFWCYYLNFFHFFFFPSYHNTIHFLIDLSSAFSFYVSFFILFFSFFWDFFIEEMIVGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C1B3</accession>
    <name>A0A812C1B3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_27580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001077">
        <property type="protein sequence ID" value="CAE1251595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C1B3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1251595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="269" mass="31922" checksum="B4F41C651CCE21B9" modified="2021-09-29" version="1">MVKNSIYYYFDFNFFITGSTVDHYSFQPVFQCDIDFTLTLYYSLFTPPCGFHLHSLYITLYLPLPVDFTYTHSILLSIYPSLWISLTLTLYYSLFNPPCGFHLHSLYITLYLTLPVDFTFTQSILLSIYPSLWILLSLLYYSFIYFTLYLTLPVDFTFTQSILLSIYPSLWISLSLNLYYSLYLPPLWISTLPHLYYSLFTPPCGFHFHSLYITLYLTLPVDFTFTQSILLSIYPSLWISLTLTLYYFLIYYSLPCGFHFPLNLFYSLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C1M0</accession>
    <name>A0A812C1M0_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">REJ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_30814</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001245">
        <property type="protein sequence ID" value="CAE1257554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C1M0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014010">
        <property type="entry name" value="REJ_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51111">
        <property type="entry name" value="REJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="REJ" evidence="1">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1257554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="173" mass="18515" checksum="A3AAEF6F997BED57" modified="2021-09-29" version="1">MSFQALNDPVPFPPRHRRLYTGDSLPTPIPRLHSTSCSTLLVASPPSELSLSPSFSLPLSLSLSLSFSLPHFLSHTLSRPLSPSVPLSPSLSLPIPSFSLPLSLILSASLSPFLSFLLFPSLSLTLSLSHTLSSSFFLPYLSLLSLPPSLTRPSFLPALSPSLSLSLSLQVNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C2Z9</accession>
    <name>A0A812C2Z9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_28637</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
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            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C2Z9"/>
    <dbReference type="Proteomes" id="UP000597762">
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        <source>
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        <source>
            <dbReference type="EMBL" id="CAE1253849.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
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        <dbReference type="NCBI Taxonomy" id="158019"/>
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            <taxon>Coleoidea</taxon>
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            <taxon>Sepiina</taxon>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C3I2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
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        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
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    <sequence length="1124" mass="133149" checksum="65F0B028642A73AE" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C571</accession>
    <name>A0A812C571_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
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</entry>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </evidence>
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    </evidence>
    <sequence length="292" mass="34817" checksum="57E0C3DFE09FF60B" modified="2021-09-29" version="1">MLDTKKKLRPLQPLLPSFCNRCCHYHSVFLWFLFFYRRRKLIPPIIDIIYLSIYLSIYLSIYQERNTALRDTSLGIYLSIYLSIYLSIYLFIFIYLSLCLPGYIYLSIYLSIYLSIYLSIYLSICSYLPIYLLRRDPNADYLSIYLSIYLSIYLSLTTLCLSICLSIYLSIYLFSYIPICVSICPSMLIYSDLSIFINAFIVMYLSMYQCIYLSILMNFQLSIYLSIYLSIYLSNVFVSIYISTNLFLSSVFILMYSYLSIYLSIYLSIYLSLSLSLYIYIYLERERERERD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001546">
        <property type="protein sequence ID" value="CAE1267619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CAE8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF5">
        <property type="entry name" value="DYNEIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="973"/>
            <end position="996"/>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1267619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1009" mass="118140" checksum="2FDDE67265E756B5" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CBX4</accession>
    <name>A0A812CBX4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">SPHA_32306</name>
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    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
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        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
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            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
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    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001339">
        <property type="protein sequence ID" value="CAE1260613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CBX4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
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        <source>
            <dbReference type="EMBL" id="CAE1260613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="231" mass="28347" checksum="0FF8416F7BBF1B20" modified="2021-09-29" version="1">MGYIRVGVARTQRQRFFFLSFFLSVNSLLYFTFSFLSFFQPISFFFQNNSSLFFFSFFQTVPSFLFLSFFLSFFLSFFQPILFFFFLSFFLPILFFFFLSFYKFSSFSFFLSTDSFLSFFLSFNRFRFLSTNSHLFLSFFLSTDSFLFLSFFLSFFSTDSFFFQPILFFFFLSFQPIPLSFFLSFFLSTDSFFFQPILFFFFLSFFLPILFFFFFSFFLPIFFFLSFFLFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CC87</accession>
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        </submittedName>
    </protein>
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            <authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
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    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <dbReference type="EMBL" id="CAHIKZ030001505">
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        <property type="molecule type" value="Genomic_DNA"/>
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        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAE1266212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="318" mass="36216" checksum="340295162334262E" modified="2021-09-29" version="1">MPLSISHPFFLFSFLLYCLLTWLVDWLVGSFLPSFLPSFLHSVSLFLIPPFLPSLTSILTASLPSLVRSFVPSFFLLVLSFYPFSLLSLIPPFLPYSLLSILGFFLLYFIPSLLPSFFTFFIFLSLPSLAPFFLGSFLPWLLSSFLPAFVPSFLPSLAPFFLRSFVPSCLPACVRSFLPSLAPFFLGSFLPSFLPSFLPSFVCSFLPLFIGSFLPSFLPSFFPPILRSFVRFFLRSFLPFFFPSFFLSFLGPSSIPYLVPPFFPPFLFSFLHPPSFHLLLLPSLLPPFLPWFVRSLLPPLLTWFLPSFLLSSILFLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CDW6</accession>
    <name>A0A812CDW6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_33433</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
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            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001401">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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            <end position="31"/>
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        <location>
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            <end position="138"/>
        </location>
    </feature>
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            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
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            <end position="202"/>
        </location>
    </feature>
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            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1262885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="250" mass="29967" checksum="CCAF6EC92A421E2D" modified="2021-09-29" version="1">MILVSIYLSIYLSIYLSILTSFHPSIYLSIYLSIHLPTYPPTYIPWTFIYLSIYLSHSVHIFLYIYLSHSFHIYLILFLSIYLSIYLSIYLSIYLSASQEELPRRYRKLYLTLNKILLSIYLSKYLILSIYLSIYLSISSMLKIFILSIIYIFSYFIFFSYLSFSSISIYHLSIYHSYISIQYLRFILIYLAIIIILFHIFLSIYLSNVLYFFISIHICLLALLCSFHSFFYIYLLSIYLSIIYLSVIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CE21</accession>
    <name>A0A812CE21_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin peroxidase</fullName>
            <ecNumber evidence="2">1.11.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Peroxiredoxin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Thioredoxin-dependent peroxide reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Thioredoxin-dependent peroxiredoxin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SPHA_34180</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Farmed</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 17">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="2"/>
    <dbReference type="EMBL" id="CAHIKZ030001446">
        <property type="protein sequence ID" value="CAE1264311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CE21"/>
    <dbReference type="OrthoDB" id="185659at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019430">
        <property type="term" value="P:removal of superoxide radicals"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03015">
        <property type="entry name" value="PRX_Typ2cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000003">
        <property type="entry name" value="Peroxiredoxin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050217">
        <property type="entry name" value="Peroxiredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681:SF163">
        <property type="entry name" value="AT16346P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681">
        <property type="entry name" value="THIOREDOXIN PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 15" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="8" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="14">
        <location>
            <begin position="133"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="302"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00078288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00079296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAE1264311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="325" mass="36550" checksum="973CAD98F9C17892" modified="2021-09-29" version="1">MTIYVLFSLSVSVHCSNASRLTPILSLSPFPLLYSLFFKYFLLRRLTNVFVCPSSLTLSSFSFLSLSLSLHNQTMSFAIDPPSSKRMGDDSLTSSSKRTDRRDRDYEASTFQFESEGDQLCEKMEKCKTGSHILPSQPAPCFKGTAVVNGEFKEISLKDYKGKYVVLFFYPLDFTFVCPTEIIAFSDRVEEFQKIGCEVVACSTDSHFSHLAWINTPRKQGGLGEMNIPLLADKNCEIARQYGCLKEEDGIAFRGLYIIDGKGILRQITINDLPVGRSVDETLRLVQAFQYTDKHGEVCPAGWKPGSSTMKPDPKQSQEYFRSAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CFE3</accession>
    <name>A0A812CFE3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_33824</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001424">
        <property type="protein sequence ID" value="CAE1263655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CFE3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="287"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="317"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="353"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="389"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="421"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="609"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="634"/>
            <end position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1263655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="670" mass="76349" checksum="2C8D4290133428A7" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CG93</accession>
    <name>A0A812CG93_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_35176</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001511">
        <property type="protein sequence ID" value="CAE1266475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CG93"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="338"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1266475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="363" mass="43142" checksum="BD67D3B42D7CCAE4" modified="2021-09-29" version="1">MGSHRSNIGGFYSLLKSLSHSLPFRSLLFLSMSFLPLSPFSYLSLQDSLFLSLSLSLCRPPLSFILSFFNHSAIFVISSFFFSFFLSFFLSFFLSFFLFLSFFSVLIYLFFLFPFLFFFSLSIHCFLLLFPSFFLSSFPSLSFIFIYFSTFSFFLSFFLSFSFLFFTAIVLSFYLSIYLSIYLSISIVFPYQCILYSILSFFLCFSYFFTAIALSFYLSIYLSIYLSINYLYRYILSFSFINIIYILFILSIYYYLSIYLSIYLSIYLYILFLINIIYTLSFYLSIYLSIYLSIYLSIYLSLYSFLINIIYSLFFLSSFFLSFFLSLLFLFLYCNSSFILSIYLSIYLSIYLSIYRHILSLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CH38</accession>
    <name>A0A812CH38_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_34618</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001475">
        <property type="protein sequence ID" value="CAE1265332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CH38"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1265332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="302" mass="36409" checksum="6EBC792C3B1C8E04" modified="2021-09-29" version="1">MPSLFLNLRSINLPFIKHTIYQTYHQYRFSHDTSITRPTIYLLPSIKFTISISSYISSLFIRFQSITIKIAIYFYPYLSSFFLDSPSIIYDITVESQPFCSFFLSFFLLSFLPSFFLSFFLSYFLSFFPFFFLSFCFLFFLPSFLLFFLLSFFLSLLFSFFPSFFLSSFLSFFFLSIIFLPFFFLSIFCLSFLPSFLPSFFLCFFVSFLFFLPSFFLSFLPSFFLSFLFYFFPSFFLYFFFLFFVSFFLFFLPSFFLPFFLSFLPSFFLSFFLHTVHFPKQSANRKFSKNIDPQKDKKKKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CHC2</accession>
    <name>A0A812CHC2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_34182</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001446">
        <property type="protein sequence ID" value="CAE1264382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CHC2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="279"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="329"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="380"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="417"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="460"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1264382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="512" mass="58335" checksum="AC06ED8018FB42CC" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CI03</accession>
    <name>A0A812CI03_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_39555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001846">
        <property type="protein sequence ID" value="CAE1275587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CI03"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1275587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="213" mass="25745" checksum="62A9037D2C54FD05" modified="2021-09-29" version="1">MGFSIFLSFFLSFFLLLLLLLLLIIIISSSSSGTHFLIFIFSHFSYFCFISFFSLFAFSFFFQTPPSFLCISHFSPFFLFPLYSFSILFLFSKPFFFSISLSFPTPLFFFYSVSFFQFFLLLHLYVFLFLFFSMCDFYPFLFFFFQFFLHLISLFFYFVFFLLLFSFSLNTLFILFFFFFFNLLPIWFELFFFSSSASSSSLFFFPLCLLLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CIR9</accession>
    <name>A0A812CIR9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_37757</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001691">
        <property type="protein sequence ID" value="CAE1272623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CIR9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1272623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="277" mass="31322" checksum="50606001EA908B78" modified="2021-09-29" version="1">MIKSRHSPLFFNSFLSLVLFSFFFKSFYFCFAVSSPSILHFLFSHIRLPSLFRHDLSLSLFLSFFLSLSLSLIITMSISFFFALSRLSLSPALSISFTFSFFSYLLYPSSAAVSLSLSLSVSSPFPIIFSSVSSFILLLPLFVFISFFSFSSTFNFKSLSACHSFRIFFFFLSYTSPLSVSFALSICLFLSFLSLVSISLSSSLSSSPPPLLTFIFISFFLSFRFFLSFFFLYFFLSSQCFSSIFLSSIFISLFNVFVSSLSPLNCSLSLFLSLSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CJP7</accession>
    <name>A0A812CJP7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RPB7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SPHA_36646</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001612">
        <property type="protein sequence ID" value="CAE1269568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CJP7"/>
    <dbReference type="OrthoDB" id="1162399at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060213">
        <property type="term" value="P:positive regulation of nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045948">
        <property type="term" value="P:positive regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04462">
        <property type="entry name" value="S1_RNAPII_Rpb7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000043">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF4">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="S1 motif" evidence="5">
        <location>
            <begin position="73"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAE1269568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="166" mass="18571" checksum="73F56C3C88F781E6" modified="2021-09-29" version="1">MIISSVAPFVRILFSSVITKFLFSLRLPYTPSYFLNSRPMNAVIPHNIGAGLIQPSRGFVVYPVKYKAIVFRPFKGEVLDAVVTQVNKVGLFTEIGPLSCFISRHSIPADMEFDPNSNPHCYKTKDEDVVIQQDDEIRIKIVGTRVDAKDIFAIGTLMDDYLGLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CJY4</accession>
    <name>A0A812CJY4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_38497</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001749">
        <property type="protein sequence ID" value="CAE1273895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CJY4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="86"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="188"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="220"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="245"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="274"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="280"/>
            <end position="303"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="315"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="344"/>
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        <location>
            <begin position="392"/>
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        <location>
            <begin position="472"/>
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        <location>
            <begin position="498"/>
            <end position="518"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="525"/>
            <end position="543"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="549"/>
            <end position="573"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="580"/>
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        <location>
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        <location>
            <begin position="638"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="672"/>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="705"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="755"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="784"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="814"/>
            <end position="837"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
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    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1273895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="889" mass="103736" checksum="65435E8741B06B9D" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CM23</accession>
    <name>A0A812CM23_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_37133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001646">
        <property type="protein sequence ID" value="CAE1271100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CM23"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="67"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1271100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="283" mass="32596" checksum="C1ADD352589B7B14" modified="2021-09-29" version="1">MSFNFFLDNWFSFLPALHFSLSFLLSALFFLSRITQTDIHFLSSFINSLAPVLFPLLLLLSLCYLPNSPIHLNYSQPRTPLSLSLSLSLSLSLSHIHTYTRMHIVGDCGDFNGHVLLLGGEFQTKNKLSLSLSLTLHIFSLSLSLSLSLSLWRCVFKLFLTLHLFLFVSLSLSFALSFFLSFYLSFSLSFFLALSFILNLYRSFFLYHFFFLNLTLSLYLYLFFSLCVFLLFAAIFLLVSSFFLTFSLSFSFFLSLSFLPFSFILSLSLPFFPFHFVFISLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CM81</accession>
    <name>A0A812CM81_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">5-demethoxyubiquinone hydroxylase, mitochondrial</fullName>
            <shortName evidence="8">DMQ hydroxylase</shortName>
            <ecNumber evidence="8">1.14.99.60</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Ubiquinone biosynthesis monooxygenase COQ7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SPHA_41565</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Farmed</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone-independent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 5-methoxy-2-methyl-3-(all-trans-polyprenyl)benzene-1,4-diol + AH2 + O2 = a 3-demethylubiquinol + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:50908"/>
            <dbReference type="Rhea" id="RHEA-COMP:10859"/>
            <dbReference type="Rhea" id="RHEA-COMP:10914"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:84167"/>
            <dbReference type="ChEBI" id="CHEBI:84422"/>
            <dbReference type="EC" id="1.14.99.60"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="8">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of a multi-subunit COQ enzyme complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion inner membrane</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the COQ7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.60" evidence="8"/>
    <dbReference type="EMBL" id="CAHIKZ030002001">
        <property type="protein sequence ID" value="CAE1279036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CM81"/>
    <dbReference type="OrthoDB" id="275371at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008682">
        <property type="term" value="F:3-demethoxyubiquinol 3-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008340">
        <property type="term" value="P:determination of adult lifespan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000377">
        <property type="term" value="P:regulation of reactive oxygen species metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01042">
        <property type="entry name" value="DMQH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01658">
        <property type="entry name" value="COQ7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011566">
        <property type="entry name" value="Ubq_synth_Coq7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11237:SF4">
        <property type="entry name" value="5-DEMETHOXYUBIQUINONE HYDROXYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11237">
        <property type="entry name" value="COENZYME Q10 BIOSYNTHESIS PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03232">
        <property type="entry name" value="COQ7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0408">Iron</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAE1279036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="212" mass="24176" checksum="B0E16FDDEB15821D" modified="2021-09-29" version="1">MVNSFGYMNYQKISSWLACIKLNTCSIQRALSTKAVASQQKAMLDRIIRVDHAGELGADRIYAGQYAILKRTTDGPLIKEMWEEEKLHRETFEKLMIQYRSRPTALLPIWNVAGFILGAGSALIGKEAAMACTVAVEDVIGDHYNSQIRELFEDDPEKHEELLKIIKQFRDDEMHHYETGLEHNAEQAPFYNTLTQVIKIGCKGAIWLSERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CMF0</accession>
    <name>A0A812CMF0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_38698</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001768">
        <property type="protein sequence ID" value="CAE1274184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CMF0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1274184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="208" mass="24003" checksum="407295E58AF8BCE8" modified="2021-09-29" version="1">MLFVETIPATVFLFLLLLLLYLSLSLSLSLSLSHQTLNYLPPISCKIFLFYPVLWSFILFFLLFSLFFTLITLLLILLHIFYLLLYCVIFFISTISFSSSSSSSDAAVFSSSLSSFFIIFGSIYLSIYLSIYLSIYLSIYLSLSLSLFLIYLSIYLSIYLSIYLSIYLSNNYTNGHRTPTLRFSALELFHASLLYIGVQILVPFFFFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CMH0</accession>
    <name>A0A812CMH0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_36508</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001599">
        <property type="protein sequence ID" value="CAE1269312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CMH0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1269312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="178" mass="21908" checksum="6D95A50A0B0F695C" modified="2021-09-29" version="1">MSFFFFPNLPILFFLSFARSIVFNFFHSFFLSYLVFVHSFYLSFLIPIFFIYCLFLSLFLSLYFYSFFLLLFNYEEYFPKFPHSPSVHVFFLSFVHNIIFDISFFFTISFVLRFQSFFKFFLSTYNIFLSHIDYFIFFLNDESPFSSFHFISVSHRYFRNIYASFVYVQPFLHRLISP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CN27</accession>
    <name>A0A812CN27_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_39028</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001800">
        <property type="protein sequence ID" value="CAE1274707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CN27"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1274707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="266" mass="30739" checksum="8E050E51BAC1A914" modified="2021-09-29" version="1">MVPLILLHPFSGDYLPSSFFFIPFFILSLLILLHPLFHHLSSSFFFISISPIVLHPFSSSPSSFFFIPFSLSLFFFPFFSLVTSFILLHPLFHHLPSSFFFIPFFFHYLSPHFLHVHFSSSPHCSSFGSSSFFFHYLSPFILLHQVFWFISPLILLHVPFSLSLPLIFFLHPFFHLPPHFFFIPFFIISPPNSSSSPFSLSSSFFFIPFFIISPPHSSSSPFSSSLLLILLHPLFHHLPSSFFFIPFFINSPHHTLSINLFSSSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CRN8</accession>
    <name>A0A812CRN8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_42186</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002048">
        <property type="protein sequence ID" value="CAE1280192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CRN8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="387"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1280192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="477" mass="56803" checksum="1EE4FBA4F7B155EF" modified="2021-09-29" version="1">MGPVLAFLLFFRKTSLLTIAPFFFFFFFFFFFFFFFFFFFFILLIFSFLSSIDYPFPSLHSVFCFVFNFLFAFLSSSILFHLYFLLPFFTFLLPIHPYFPPCSRLFSNFHLFFLPLFLPFFLFSSPCFSFISILFLTFSFSFIIHFKLFPFLLFFCRFFFPCVFFFCFVFFQHSFSSSFSFPNLFMFLLLRHIIEIFSFFFASSLLLHFFSSAFSFFFHFFFLPPLPFLPPPSFSFSSFHFRLPFLLLLLIFFHSAFHFPSFFHFFLLLISFLLRLSFSFLLSPPSSHFFPFLAFHFPSLLSLRLSHFFHSAFHFPSLLSLRLSHFFHSAFHFPSLLSLRLSFLSSSQPFISFPFLFHLRLSFSFLLPFIFLPSFHSASLISFTPPFIFLLFFQSTSPFPSLLSYRLLNHIFRSRISFSSQTFDDLTDLPPFLFPAFCLPCLSTLTHPPSLPYLSIYSISPIYLSFNFSFSLTLSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CTU0</accession>
    <name>A0A812CTU0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_41944</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002024">
        <property type="protein sequence ID" value="CAE1279671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CTU0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="302"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="368"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="399"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="434"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="538"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1279671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="568" mass="68411" checksum="7D1408E7FBF2B01A" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CTU4</accession>
    <name>A0A812CTU4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="14">TLR2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SPHA_41613</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Toll-like receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002005">
        <property type="protein sequence ID" value="CAE1279087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CTU4"/>
    <dbReference type="OrthoDB" id="5966846at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10140:FF:000001">
        <property type="entry name" value="Toll-like receptor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24365:SF541">
        <property type="entry name" value="PROTEIN TOLL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24365">
        <property type="entry name" value="TOLL-LIKE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13676">
        <property type="entry name" value="TIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01537">
        <property type="entry name" value="INTRLKN1R1F"/>
    </dbReference>
    <dbReference type="SMART" id="SM00255">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0391">Immunity</keyword>
    <keyword evidence="3" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="TIR" evidence="13">
        <location>
            <begin position="117"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAE1279087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="264" mass="30970" checksum="21EC34AD70F515FE" modified="2021-09-29" version="1">MCDNIFPVLLYMNVCNIEFGFHDGKPRSIKASGLTDTAYTERRSYFIPFSNDNAAMLILFIAVTSSWAGAFVASSCSDQCASVCKWGFIYRYRWNLRYFYYMMKARYSFQNEKAENFVFDAFVSYSEDEGEFVINKMIPELEEHGNLHLNIHHRDFVPGRKIVENILSAIQQSRYCLVLLSSGFLKSQWCMYEFSMAKMETVYAERDMVVVIMLEEVDTESIPLELMHHLKTKSYIEYPTRDEQGQQLFWNNMRDLLQGKAERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CUS1</accession>
    <name>A0A812CUS1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_43893</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002224">
        <property type="protein sequence ID" value="CAE1283153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CUS1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="328"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="364"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="427"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="468"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="496"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="524"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="585"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1283153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="627" mass="74466" checksum="20159EAD0C015B9F" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CWK4</accession>
    <name>A0A812CWK4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MLH1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_41175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001972">
        <property type="protein sequence ID" value="CAE1278308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CWK4"/>
    <dbReference type="OrthoDB" id="10263226at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032389">
        <property type="term" value="C:MutLalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032189">
        <property type="entry name" value="Mlh1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF12">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16413">
        <property type="entry name" value="Mlh1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein Mlh1 C-terminal" evidence="1">
        <location>
            <begin position="64"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1278308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="336" mass="39346" checksum="DF8984A446DF3E9E" modified="2021-09-29" version="1">MLMSIQPSMRSTSLMKAVSSRVYRRPSRLNFLVQTCPGRIIHRPYFQALQSIWMMIIMKTKFHQIQLKKKEFQKNYHSGLREIFQNHKFVGCVSKELALIQHQTKLYLVNTFKLSRELFYQLLLLDFGNFGAIRLSEPAPLYDLAMMAFDLQESGWTPADGKKEDLATYVTDFLKSKREMLEEYFALEIDTDGNLCTIPMLLENYVPPLEGLPMYILRLSTEVNWEEEKECFMSFCKETSEFYAFRNNELQNAEPVLASPSQTEEPDQNMDDNWKWTTEHVLFPAYRARCDVHLDDYVSCRLPSFPYRRLGDFGLFDSPRSLGVTHDERLGDHVSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CZS3</accession>
    <name>A0A812CZS3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_46309</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002445">
        <property type="protein sequence ID" value="CAE1286953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CZS3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1286953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="286" mass="33422" checksum="F2547CEDD3A527EE" modified="2021-09-29" version="1">MGVQNNDKRKTSENGYKFVNSLSYWIDCQSKYGWVVAANSNGQGLSFKLALRAFKKSPLFFVRLSSPLTVIITEIFNCFFLFALYFSFFIFVSFFHSYFSFSITFLFMSFLFFLPLFSSSLSETILPSYKHYFSLFFFLKSHFCYFSFSPSLFYFLSPSIDYCNFLCFLSSLFLPVNAFPTISSVLHDSLLIRSFSYSLYFSLYLSLTHTNTYTQIHTCILLMLPILSRIYFFYFLFFNMSLTHMQPHARTHQCQFLSLSLSLSLSLSLSLSLSLHAHIFPIYSFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D3B5</accession>
    <name>A0A812D3B5_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">inositol-1,3,4-trisphosphate 5/6-kinase</fullName>
            <ecNumber evidence="3">2.7.1.159</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SPHA_49222</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Farmed</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ITPK1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.159" evidence="3"/>
    <dbReference type="EMBL" id="CAHIKZ030002795">
        <property type="protein sequence ID" value="CAE1292339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D3B5"/>
    <dbReference type="OrthoDB" id="25308at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052726">
        <property type="term" value="F:inositol-1,3,4-trisphosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052725">
        <property type="term" value="F:inositol-1,3,4-trisphosphate 6-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047325">
        <property type="term" value="F:inositol-3,4,5,6-tetrakisphosphate 1-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032957">
        <property type="term" value="P:inositol trisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008656">
        <property type="entry name" value="Inositol_tetrakis-P_1-kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040464">
        <property type="entry name" value="InsP(3)kin_ATP-grasp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14217">
        <property type="entry name" value="INOSITOL-TETRAKISPHOSPHATE 1-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14217:SF1">
        <property type="entry name" value="INOSITOL-TETRAKISPHOSPHATE 1-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05770">
        <property type="entry name" value="Ins134_P3_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="138"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Inositol 1,3,4-trisphosphate 5/6-kinase ATP-grasp" evidence="11">
        <location>
            <begin position="11"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAE1292339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="198" mass="22066" checksum="10166F22C2C01533" modified="2021-09-29" version="1">MDKSEIVNSPVKPNITKLKELGRHIRSHLQLSLFGVDVIIECGTNRYAIIDINLFPGYKEINGFFDSFERYILQLLDSKKADRNADNKRSQCPVDSLTISNNCKKLKVQDSSSDDAEKEDIETFAAPLSFTLSSLSPAFLSLLLSLFLLSIAFPLACLSSLSLLSLAFSLSCLSRFPTFLPFSLSLFLLFLFFSSLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D776</accession>
    <name>A0A812D776_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]</fullName>
            <ecNumber evidence="9">1.3.1.88</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SPHA_48189</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Farmed</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>5,6-dihydrouridine(16) in tRNA + NAD(+) = uridine(16) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53380"/>
            <dbReference type="Rhea" id="RHEA-COMP:13543"/>
            <dbReference type="Rhea" id="RHEA-COMP:13544"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:53382"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>5,6-dihydrouridine(16) in tRNA + NADP(+) = uridine(16) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53376"/>
            <dbReference type="Rhea" id="RHEA-COMP:13543"/>
            <dbReference type="Rhea" id="RHEA-COMP:13544"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:53378"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>5,6-dihydrouridine(17) in tRNA + NAD(+) = uridine(17) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53372"/>
            <dbReference type="Rhea" id="RHEA-COMP:13541"/>
            <dbReference type="Rhea" id="RHEA-COMP:13542"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:53374"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>5,6-dihydrouridine(17) in tRNA + NADP(+) = uridine(17) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53368"/>
            <dbReference type="Rhea" id="RHEA-COMP:13541"/>
            <dbReference type="Rhea" id="RHEA-COMP:13542"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="13">
            <dbReference type="Rhea" id="RHEA:53370"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the Dus family. Dus1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.88" evidence="9"/>
    <dbReference type="EMBL" id="CAHIKZ030002657">
        <property type="protein sequence ID" value="CAE1290421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D776"/>
    <dbReference type="OrthoDB" id="272303at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082">
        <property type="entry name" value="TRNA-DIHYDROURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082:SF5">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(16_17) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="14">
        <location>
            <begin position="1"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAE1290421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="399" mass="45289" checksum="F2123FA63A154A40" modified="2021-09-29" version="1">MLHASVFTRNQTYREESLTTCEEDRPLIVQFCANDPNTLLKAAKLAENSCDAIDINLGCPQKIAKKGHYGAFLQDEWDLLYKMVNLCHRKLHVPVTCKIRVFESIEKTVNYTQMLEKAGCQLLTVHGRTREQKGPLTGLASWKHIKAVKENVNIPVFANGNIQYLEDADRCVKETGVNGIMSAEGNLHNPALFNGVSPPVWEMAEEYLELVDKYPCSTSYIRGHLFKLFQHAVQIHEDIREEVAKAKTVQCFKSATQQLKEKCLHDIEHSKEDPSIAHKLGLPHPYWICQPYVRPDPSPVNKDSNATSEKGGKLKRPLIELSVEDSNLSKKKLKKKLRNPGKLFDAALKIKYERCSLCANPKGQKCCYALCKNCCRKKTYVEILDCSGHHFSFKSRSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D7X8</accession>
    <name>A0A812D7X8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_48144</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002655">
        <property type="protein sequence ID" value="CAE1290368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D7X8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1290368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="326" mass="40140" checksum="89559C1E2D90F5D8" modified="2021-09-29" version="1">MSEYFVYLLTHESIAKPFFLFIALSFFLPFFLSFQYLSFFFLSFSVSSFFFFLFISFFFFLSFQYLSFSFFLFHIFLFLSFLFSIFFFFLFSIFLFFLSFQYLSFFFLSFQYLSFFFLFSIFLFSFFLFSIFLFSFFSVSFFFFHSFQYLSFSSFLSFHYLSFFFLSFQYLFLSFFLFSIFLFLSFFIIFLSFPHFSFFSLHYLSFFSLSSFFLSFFSLSFFSSFFFLFLSFFSLSFFFLFHYLSFDFTSFLFPHYPFITFSFLTTFYLSIYLSIYLSRYLALVPFNSIYLSIYLSIYLSIYLSCSVFIYLFLSIYLSIYHLSITV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DBE1</accession>
    <name>A0A812DBE1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_50341</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002947">
        <property type="protein sequence ID" value="CAE1294347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DBE1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1294347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="293" mass="34532" checksum="85AE99D099B43167" modified="2021-09-29" version="1">MFLQCTNPLFAFFPQFCFIFLKQYRNIFSIYCLLLNLHKYTHLDIPTFIPVSFLSLSSSNVSLPFKSLSFFSLSLSLLDLCIVLMLLLLCLFPQVHFFFLFFFLFFFYSIYLSFTLNLSLAFTLCLYLSLTLYLYLTLTLCLLLLLYIYISFMLRFSHTISLYLSFALYLFLSCYISVFFLYIFSFSFPSLSFSPFPLFFPHLPSLYFFPISLPSIFSPSPFPLFFPSLPSLYFFPSLLSLPSIFSFSPFPLFFPSLLLFFFSYTHNDIYLLFTLSFTLSFSFTHPYIDLVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DBT2</accession>
    <name>A0A812DBT2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_53028</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003337">
        <property type="protein sequence ID" value="CAE1299109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DBT2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1299109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="269" mass="31119" checksum="81B157A240D31C26" modified="2021-09-29" version="1">MLTMFKKSQFNTEQIFFFFFFFFFFFFFLLLLLATSLQVFCLSHGLQLLMTLTSNPPLYRNLSFFLSVRPYLSFCFSLFFPISLFSLSTSLSLFLFLSLRPYLFFSLSTSLSLFCFSLYVPISFFFSLVPISLFVSLYVPISLFFLSSSLSLFVSLSTSLSLFFSLSPSLSFFSLRPLSLFVSLSTSLSLFLFLSLLPYLSFCFSLYVPISLFFLSLRPYLSFCFSLYVPISLFVSLSSSLYLFLFLSTSLSLFLFLSLRPYLSFCFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DCN2</accession>
    <name>A0A812DCN2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_53763</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003432">
        <property type="protein sequence ID" value="CAE1300309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DCN2"/>
    <dbReference type="OrthoDB" id="9635126at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23304:SF189">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23304">
        <property type="entry name" value="SPOT2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="196"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="236"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="326"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="365"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="389"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="414"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="437"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="467"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="495"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="528"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="573"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1300309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="600" mass="71964" checksum="CF112847BF5D7192" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DCY1</accession>
    <name>A0A812DCY1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_50072</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002922">
        <property type="protein sequence ID" value="CAE1293904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DCY1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1293904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="221" mass="26035" checksum="F2CD6CE54AA47742" modified="2021-09-29" version="1">MLSRLALCYFLLGANEIFSISLALSLSLSLSLSLSRFLSCYTKTIKKYLPTYLPIYLSIYLSLSICPYISMYVWMYVSINLYHFILFVSIYLFIYLSIYLSIYLCLSPVHLYITNIKYIYLSIYLSIYLSIYLPHTVRIYVSIYLCISLCSYLFILLYSVSIYLSIYLSIYLSIYLSIFLSVCLFVPLNRLHSFQNNGFSNEEFLPNYFSFCINFFLKTLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DDR1</accession>
    <name>A0A812DDR1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_51047</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003063">
        <property type="protein sequence ID" value="CAE1295718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DDR1"/>
    <dbReference type="OrthoDB" id="9635126at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134:SF22">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134">
        <property type="entry name" value="OS08G0543275 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1295718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="272" mass="32131" checksum="EAD2D84F549AA735" modified="2021-09-29" version="1">MSVFPFLHHFDNYLSIYLSIYLSKSVHIYDPSISSVQIYLSLFIFIYLSLFIFIYLSLSIHIYLSISVHIYLSIYLCSYLSIYICSYLFINLPLHIYLSISVHIYLSIYLFISIYLYLFIFIYQSTSVHIYLSISVHIYLSIYLCSYLFINLPLFISIYLHLFIFIYQSTSVHIYRSIYICSYLSIYLSISVHIYLSTYLCSYLSIYLSISVHIYLSIYLCSYLSIYLSLFISIYLSIYLSISVHIYLYSYLSISVCSYLSISVCSYQSISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DII3</accession>
    <name>A0A812DII3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_57021</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003815">
        <property type="protein sequence ID" value="CAE1304444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DII3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1304444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="378" mass="40553" checksum="6C024C2CA0B6111D" modified="2021-09-29" version="1">MIAAATNESSSLKPSKVRTATCITLAFVRRTASASHRDPDRAGLILRDMDTPAPAEARPLRGDIAAAGPTAGEQPLANGRVEAAGHRVFDQPAMRAGEERAQFERHLATGACGPTMPMSICSGWYRAGSTASTASADPSMTAIQPGPLSAQCGIDNRRAVDPQQLCDLSDLGFGRRAAAQQRWGGKKQAGRHRVGSSPARRRIPARSRRPASIVRPLPPTHAHCRSGRMPGEGQFVRHGEDAQLAIACISSVVRPSASAMTASGLPVSGSVPNTSTRRKGRSRASPVDDGWSYRATTGADRYTSVRSCRTVLVRLAVRWRAPLTKPAPAWWSRDPRPNRRPHADAGRPAAVDPRDGRDERRRARSTVVEAMIASRPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DL00</accession>
    <name>A0A812DL00_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_55550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003713">
        <property type="protein sequence ID" value="CAE1303421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DL00"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1303421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="206" mass="24304" checksum="9864FCF72C7A2F75" modified="2021-09-29" version="1">MTNLSISFCSYLSIYLSIYLSIYLSHSLSHSVNIYLSIYLSIYLSIYLSIYQSVYLSIYLSIYLSIYLSHSIPIYLSIYLSIYLSIYQVINQSIELSYFIHTYLILYIHIYLSIYLSIYLSIYLSIYLSHSIPIHISINLSSDLSILFYTYLSIYISICLFTYLCHCISIYPILFLFVYLILFLSIYLSIYLSIYLSIYLSIYLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DPN0</accession>
    <name>A0A812DPN0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_60372</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004198">
        <property type="protein sequence ID" value="CAE1308507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DPN0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="336"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1308507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="357" mass="43078" checksum="C8DC6FC91D278C14" modified="2021-09-29" version="1">MSPNHLGNLCNYTVYCPGKWFLSDAILYFLSYAPFLFSFFLSFLSFSSFIRLHISFFLSFFLSFILLDFFFYFFLFFIALSFFFFFRSITFFFLSLFSFVRLHFSFFLPFSSFLSFSTFVRLHFSVYFSFRFLFFFHSNFPLLYSFFLSFFLSFFHNIKGFTFSFSHQNLRLFFLSFELPFCFFSFISIFFSPTTFQFVYPFFFSPSFFSFYVLSFIYCPLLLLFNHSLFRSSFLPLTCSTCSRSFSSPPFSLLLLPKFLLQLFTFVSYSAFSHFLFFLFLFIFLLLHHLHLLHLLLLLLLLIIIIIIIIIAILFLSFELSFQFCIFHLSFVPSNFIFHLFLFLLSPFFFKLFSNPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DSA9</accession>
    <name>A0A812DSA9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_58192</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003966">
        <property type="protein sequence ID" value="CAE1305849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DSA9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1305849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="218" mass="24323" checksum="4A30D718FBFEE99C" modified="2021-09-29" version="1">MYFIASSLDYLLSLSFLMIFIADTVLVVVILLPSFLSLSLSLSSSFSPLPSLFFFFCLLLISPLSTSFLSPPPHFFLFISFLFLFLPLLLLLSLSPPPPIFSLSSLYFLSLLPLLSLTCSSSFFSYSSLFLSTSSYFFFPCSFLSPHYSLSLLILSFPLSSFLSLSLLLLRALTLSLSFFFFSFRAHFLPPPIFSPPPLSPSSLSPTFSFLLLLLFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DT35</accession>
    <name>A0A812DT35_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_59378</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004111">
        <property type="protein sequence ID" value="CAE1307275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DT35"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="309"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="347"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="393"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1307275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="427" mass="50353" checksum="86BA5ED46E82551F" modified="2021-09-29" version="1">MTRNPVHINQSVQSQTWLPPSEKLPTISPSPLSDDFLFILSTAFSVLPSFSNFLWSSAFLFSYLFLTLPFFCLYLLFLNFYFLFYSFLLPFYSIFRFYHRHFLWSFLLAHLLFLLFFSFHSYSLHYPFHSIYLFCVSPFLTLSLSLFSLTLSLSSLSLSLSSLSLSLSLSSTYFFHYFSFSFFFSISPSSFVDFFPLFIFSLFSRCRFSTLSFFSLLFPLLFISLFAIASSPSLSHYLPSVPFLSTLLLISLPPLSLSPSLSLSLVAFSSFLLSFSCFSSFLSFYTRLLYLLFPLLCCRLSLSSFKCTFLPSLIPYFSLFFTFFFVYSSSDCSCFPFSLSPHSLASLYLFFSSSCRTILSLSLTSLFPCFYHSVLFLRIESRIYLLLYHHHQLLLLFFFFFFFFFFFFFFFFFCCCFFFFFFFFFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DWN8</accession>
    <name>A0A812DWN8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CCDC92</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SPHA_63592</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004561">
        <property type="protein sequence ID" value="CAE1312318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DWN8"/>
    <dbReference type="OrthoDB" id="2155209at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040370">
        <property type="entry name" value="CCDC74A/CCDC74B/CCDC92"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039496">
        <property type="entry name" value="CCDC92/74_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14882:SF1">
        <property type="entry name" value="CCDC92 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14882">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING 74A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14916">
        <property type="entry name" value="CCDC92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCDC92/74 N-terminal" evidence="4">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="149"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="5"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="165"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="188"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="243"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="264"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAE1312318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="380" mass="42790" checksum="4CCFF0AD0F77BF4A" modified="2021-09-29" version="1">MLFLRQEHAKTLKGLHEEIKVLQKRCTDLTFKLTMQGLHTEDTTELEAKVKKLETELEAAKSNETHLLEVLTKERNKIKELEIQLKYQAIKHNQELASKEKELNSLRADLDYKADYIGHLSTELHKAKIQQKLEENLNMKSKENVFHVVPVPPKNAPGSAGGGGRHSRRSHMQKSRSDEVELSEAWHSSSPSSGRSSATLRNHGSRLNSPHQPGMTQTNSSSSQELSELSPSSSSPPQFLNRDHHHHHHHHHHHHRHMGSAGGNNNNNNNSSSSSHNGNNNNNNNNNNNNMCSNMSPSSSLLIKSKPAPRLLPPIRQNGGQIQSQNLRHVYVKNVVRPHCFRAQSCECNAPQVETLAVDPIGRLDSSWRNAHHPKSTEYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DWX0</accession>
    <name>A0A812DWX0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_63023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004519">
        <property type="protein sequence ID" value="CAE1311660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DWX0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="291"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="361"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="385"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="420"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="457"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="495"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="525"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="557"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="582"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="626"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="667"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="712"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="758"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="789"/>
            <end position="816"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1311660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="820" mass="95972" checksum="1516F5EFAC535455" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DYB1</accession>
    <name>A0A812DYB1_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Protein disulfide-isomerase</fullName>
            <ecNumber evidence="4 13">5.3.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SPHA_64748</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Farmed</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="4 13"/>
    <dbReference type="EMBL" id="CAHIKZ030004665">
        <property type="protein sequence ID" value="CAE1313661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DYB1"/>
    <dbReference type="OrthoDB" id="72053at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02982">
        <property type="entry name" value="PDI_b'_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02981">
        <property type="entry name" value="PDI_b_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000023">
        <property type="entry name" value="Protein disulfide-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000030">
        <property type="entry name" value="Protein disulfide-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000042">
        <property type="entry name" value="protein disulfide-isomerase A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005788">
        <property type="entry name" value="PDI_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005792">
        <property type="entry name" value="Prot_disulphide_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01130">
        <property type="entry name" value="ER_PDI_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01126">
        <property type="entry name" value="pdi_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929">
        <property type="entry name" value="PROTEIN DISULFIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929:SF240">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13848">
        <property type="entry name" value="Thioredoxin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 13 16" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10 11" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033099267" description="Protein disulfide-isomerase" evidence="13">
        <location>
            <begin position="18"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="15">
        <location>
            <begin position="11"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="715"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="719"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="11">
        <location>
            <begin position="55"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="11">
        <location>
            <begin position="395"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605792-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAE1313661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="782" mass="87678" checksum="A91E3A5EA9644508" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DYS3</accession>
    <name>A0A812DYS3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_64718</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004663">
        <property type="protein sequence ID" value="CAE1313624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DYS3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134:SF22">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134">
        <property type="entry name" value="OS08G0543275 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1313624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="305" mass="36055" checksum="5138349702FB6D3D" modified="2021-09-29" version="1">MIFYEFSILVSCSYLSIYLSIYLSISFSLYLSNSLSIYLSICFHSIFISIYLSIYLSIYLSHSPYMYVCIYLSIYLSIYLSVYLSFCFHTFFFLSFSLSFFLSIYLSHFLSIYLSIYPCLFINIYLFLSVCVYLSIYLSHSLYMNLYMYLYIYLFSYIFLSIYLSIYLSRSLSIYPCLFINIYLFSHIFIYLSIYLSIYLSIYLPLSVHKYLSIYSCLFVSIYLSIFLSNSVPIYLYISVLISYLFFVYCLYQFQPIYLSIYLSIYLSFSISLCLFQLLRTGGSLLSLSSKILQQISQLTATIVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E007</accession>
    <name>A0A812E007_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_61823</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004391">
        <property type="protein sequence ID" value="CAE1310190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E007"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="320"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="350"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="420"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="463"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1310190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="496" mass="59662" checksum="6097E6556C1F634B" modified="2021-09-29" version="1">MLSFFFHLFFSFFYLKSLHFFFVSLTLLFFPLKYFRVFMFVIFLVFPFISGTFFPFYSPFSSCFLSINPFVFCFFISLFRSLFFIILSQFYLFFFLCFPFFKTINCSSLSFLLLTFLFFKVHSFFSFVSFIFFFFFVFILPPMIFSFSFFRFLKVFVRSSLLHFPFLSLKSFYVFIFLFLLFIFFFYFILRSFPFFLLLLSSSSYFFYFPLLKIVFFLFILSPVFSFPLFKIPSQFFPLSLLFSLFPFFKICWYFLFACLIYLHTVSLSRLHVLVSYSSLPIFVFFLILFYLSIYLSIYLSIYLSIYLSIYVFHNVGNNIYGPSCKMVVSHSIFFSLFKYYSIRFYFSHFYSLLTSVFFSILSISLFLLLCFYIFLYLTLSQPPLSLYFLYQPIAFSLPLFLSASLSLSRSFSFSFSLSLFTIEIYLSIYLSIYLSIFVYIYLSIPVHLFFSIYRTQKCSHLSIYLSIYLSIYLSISVYIYLSIPLAIYLSIYLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E0Z6</accession>
    <name>A0A812E0Z6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_66174</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004770">
        <property type="protein sequence ID" value="CAE1315192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E0Z6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1315192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="208" mass="24436" checksum="0409D7E988F16022" modified="2021-09-29" version="1">MVTIFYLIYLSIYLSIYLSIYLSIYLSSIHISLSIYLSIYLSVCLFLNMSLYLKLSVSCYVFIFKNIYLSIYLSILISLFLSHYRLFILSCHISLRLFFSFQTFSLSLLLSFALFPNLFTFSFFLIPIIPFFFSLTYVSFYFLPLFSLLFSMSCLRWGVLKVLWSHASYISDLDLIRPPPLSLSLSLSLSLCLYSPVYMLFTFSFYNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E151</accession>
    <name>A0A812E151_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_63639</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004566">
        <property type="protein sequence ID" value="CAE1312398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E151"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1312398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="182" mass="21434" checksum="8C8DE77C1768B394" modified="2021-09-29" version="1">MSVNISTSQQSFLISRFPCVHIYLSIYLSIYLSIYLSIYLEQSVCLSIYLSSYLSFYVCSYLSIYLSIYLSIYLSIYLEQSVYLSISVVIARFMSVHIFRSVSIYLSIYLSIYLSIYLSIYLFLYLYIYFSVYLTYLSIYLSIYLSIYLSIRVDDSLCQSICPVVECVERLCMILRNQVNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E1C9</accession>
    <name>A0A812E1C9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_64167</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004620">
        <property type="protein sequence ID" value="CAE1312996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E1C9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1312996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="174" mass="20125" checksum="96BD4E89305AB3E2" modified="2021-09-29" version="1">MLLMNKDAMRVSPAVDFLSYSISSPTIGNNMASRLNVYRDTIATFRVSVRRSSTSTKKYFPKTCSIPANGQCVIAHAGRKAHEESKFLKPERKAHEETKFSKPERKPQEESKFPIPGRKAHEESKFLKPERKAHEETNYSKPERKAHEETNFSKPERKAYEETNFLKPERKAHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E2I0</accession>
    <name>A0A812E2I0_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase M16 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_63451</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004545">
        <property type="protein sequence ID" value="CAE1312181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E2I0"/>
    <dbReference type="OrthoDB" id="4953at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000031">
        <property type="entry name" value="Putative zinc metalloprotease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016:SF16">
        <property type="entry name" value="METALLOPROTEASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G07610)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016">
        <property type="entry name" value="PRESEQUENCE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="2">
        <location>
            <begin position="525"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="183"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1312181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="743" mass="84864" checksum="94DBB59ACC3BCD41" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E4M0</accession>
    <name>A0A812E4M0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_64277</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004626">
        <property type="protein sequence ID" value="CAE1313133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E4M0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1313133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="309" mass="35911" checksum="B3DC7F125D975289" modified="2021-09-29" version="1">MTLSRHARLSPVRLRAAVVKWASRDDYWTTLRPAGRRCQACRRWVPAKQQLHKRQSFLSICLSLLIYIHSYLSFYLNLCSFYQRFPIYLPVYLSQLSYLSIYLSIYLSISPFLSIYLSIYLFQSVPIYLSSLVCSYLSIYLSIYLNLFISIYQSIYLSISTFLSIYLASLFSLLICITVFLSITLFSSIYLSIYLSIYLSIYHNLSAFSYLSHFYLSHFSYLSIYLSIYLSIYLSILVCFISIYLSISVCSYLSIYLSIYLSIYLSIYILFNFTFISFSKSRKSPIPDTGVKGAQNVLCITQNMDSTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E4X7</accession>
    <name>A0A812E4X7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_65774</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004732">
        <property type="protein sequence ID" value="CAE1314757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E4X7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
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        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="302"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="413"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="442"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1314757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="466" mass="56956" checksum="0BD23FFDA09573C7" modified="2021-09-29" version="1">MRNKLTHNSFIADVLFPLVYCTCVRIFFIPRLLFLAFSFQLYFFLLLLSFISFSFSFIFPFLCDYPSISSSFSCFFIDFPSCLSFFSLHISLHVFHSFPFMFFIDFPSCFSFFSLHVFHSFSCFFFSSCFSLISFMFFILFLYVFSFFPLFMFFIFSFMFFILFPFFHSFFPSCFSCFFHFFIHFPSCFSLISLHVFHSFPFMFFILFPSCFSFSFLFSLSLHVFFIDFLHVFHSFFPFMFFILFPSCFSLISLHVFSFIHVFSFFCFSFHVFHSFPFMFSFFSFVFSFSFLHVFHNSFFHSFPFIIFHFFPSCFSFFSFHVFSLLFPFMFFSFPFHFFFFPSCFSFFSLHRFPSFFSFLFLHVFIHFPSCFFIFPSCFHISFHVFILFLSCFFIVFHFFFFPSCFSFFSLHVFHRFPFMFFIDFPSCFSLISLHVFHSFPFMFFIFSLCFFSLFSPFFHSFHVFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E501</accession>
    <name>A0A812E501_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_66387</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004787">
        <property type="protein sequence ID" value="CAE1315419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E501"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1315419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="249" mass="28823" checksum="C9D4541C3727CDB8" modified="2021-09-29" version="1">MAFYRIFPVSTPSIRVSVSLFSLGFSIYLYLYLCIYLNSLSLSLSLSLSLSLSASDTNTEESRGADINCFSSSCYRSISVQPFLLDPLLVFLPTLLFLSIFPTFLFLSIFSTLLFLSIFLTFLLLSFLLFSFYLTYPSLSIFLTLFFLSFLLFSFYLFYSSLSIYLSYSTLSSFPTLLFLFVFPTLYFFSTFLFLSIFSLMFYPLMHTFLLIVAHRTFIYLSIYLSIYLSIYLSLSLSLFLSQFLFSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E5P8</accession>
    <name>A0A812E5P8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_64848</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004677">
        <property type="protein sequence ID" value="CAE1313812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E5P8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="25"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        </location>
    </feature>
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        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="207"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="458"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="488"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1313812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="513" mass="56603" checksum="61C4165BAFB2B3C9" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E9P2</accession>
    <name>A0A812E9P2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SLC44A2_4_5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_70985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005201">
        <property type="protein sequence ID" value="CAE1320868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E9P2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1320868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="285" mass="33396" checksum="B7B78125CEF2FB71" modified="2021-09-29" version="1">MMRSYADHIITSVERYGLSLPDHDKWTIIIQKYFKEHCSVRIIEHSLFFSLSFLFSLTFPLFFLFFFFFFSLHKSNFTPGPAVTEIYTFFLSLFFFFFLSSSVYSSASNTVKTATGIYTFFLSLVSLLFLQTQRLVLFYPVVTFLYLSTFSFYCSLTSIIACSSSLYKKIFNIFTWHFMLLFLRLGICTQIIQTVQFFQYFERPLVLCLKWSTVRSFFSVCLVTTAEIFLFHLPSYSAFFSSDALIIFEAQYLSVFCLHHFLATTKFLSSEANLAARLLYRQPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EB32</accession>
    <name>A0A812EB32_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_69431</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005077">
        <property type="protein sequence ID" value="CAE1318986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EB32"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1318986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="169" mass="18416" checksum="55A429FECD306750" modified="2021-09-29" version="1">MVIERRRNGDCVVYLVELEGGMVIESDVVYLVELEGGMVIESDVVYLVELEGGMVIESDVVYLVELEGGMVIESDVVYLVELEGGMVIESDVVYLVELEGGMVIESDVVYLVELEGGMVVIESDVVYLVELEGGMVIESDVVYLVELEGGMVIESDVVYLVELEGGMGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EB35</accession>
    <name>A0A812EB35_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_69806</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005106">
        <property type="protein sequence ID" value="CAE1319464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EB35"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="147"/>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAE1319464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
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</entry>
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    <accession>A0A812EB38</accession>
    <name>A0A812EB38_ACAPH</name>
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        <submittedName>
            <fullName evidence="4">CEP350</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">SPHA_69032</name>
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    <organism evidence="4 5">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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            <taxon>Coleoidea</taxon>
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            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Farmed</strain>
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    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <dbReference type="EMBL" id="CAHIKZ030005053">
        <property type="protein sequence ID" value="CAE1318567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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        <property type="entry name" value="DUF4378"/>
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        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
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        <property type="entry name" value="CAP-GLY DOMAIN-CONTAINING PROTEIN-RELATED"/>
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    <dbReference type="PANTHER" id="PTHR13958">
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="Pfam" id="PF14309"/>
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        <source>
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            <dbReference type="Proteomes" id="UP000597762"/>
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    <sequence length="2979" mass="332192" checksum="72AEB3F254265A77" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EBD1</accession>
    <name>A0A812EBD1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PTPRT</fullName>
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        </submittedName>
    </protein>
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    </gene>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1322003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="228" mass="26585" checksum="DC89A90009AA7453" modified="2021-09-29" version="1">MVFSLIILSSLFYQLSLHFCSWYSLLILFFSFINCLFTFCLWYSLFDSCFILFYQLSLPFLLMILSFGFLLSSLLLTVSSLFAHGTLFWILDFFSFINCLFTFCLWYSLLDSCFLLFYQLSLHILLMVFSFGFLLSSLLSTVSSLFAYGTLFWSLVFSLLSTVSSLFAYYGILFFDSCSFFSSRFLLSFINYLFTFCLWYSLLILLSSLLSTVSSHGTLFLLFMSLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EC20</accession>
    <name>A0A812EC20_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_71592</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005241">
        <property type="protein sequence ID" value="CAE1321518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EC20"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="409"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="443"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="482"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1321518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="513" mass="61398" checksum="6C1FD9DDB3089706" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EC89</accession>
    <name>A0A812EC89_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_69904</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005110">
        <property type="protein sequence ID" value="CAE1319600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EC89"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1319600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="247" mass="29527" checksum="46869FEF13D80296" modified="2021-09-29" version="1">MGILRTEKFDLFTAAAVCTFGSCERGRDEHGNRHIHTWNDGSNESLFQLKESFKTQNKCRQKQSGFNAIIFHNAFSLCFFLFIIYYVLLLNFPLLSLALFSSFSSNFFFFPSLSFILLTFFYHCFLSTFYASFSFFLYFFLILSFCFYLTILSLFFFLSYSLFFLSLSLFYLILFLLFFFLSFFLIILSLLFLSIILLILPLLILHFFLSTFTLLLFFHFPLFLTHYFFYFLFTGYCFFFFLSLSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ECK3</accession>
    <name>A0A812ECK3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_70621</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005169">
        <property type="protein sequence ID" value="CAE1320315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ECK3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1320315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="329" mass="38894" checksum="CA98867D41AE9721" modified="2021-09-29" version="1">MYVTERLTLQLIERILYLSIYLSIYLSICSYVNLLFIIYLFTSISHYFGCFYISIEMFVHINLSQNLSLSLSLARAIYLSTDLPTYKCNKMKISFDAENYTTTTTTQRVRQDITHRKKHLSIYLSIYLSIYLSPFVYIVFICSDVSINFASLHIYPFICIILSQAFLLPYPIYLSIYLSIYLSLCSNLSVHIFLCQLLNIYLSIYLSIKWTNYHVKRIIYLSIYLSIYLSIYLSIYLSIYLSQSLFKSQYLSIYVYSDRSIYLSIYLSIYLSIYLSIPVSVQISVFISFYVNHFTTMFIIYLSIYLWHTTQYFILEEILSLITRSSTES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EEX8</accession>
    <name>A0A812EEX8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_69980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005114">
        <property type="protein sequence ID" value="CAE1319654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EEX8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1319654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="201" mass="23936" checksum="4E1AB27E95A13FA3" modified="2021-09-29" version="1">MVISLTASFHFLCWLSLRHLLTLFFFHSFSFSLSITASFLSFFFLFLFHYLTNSFLSLSLSLSLNIPTYFQSLFLSPLSLSDYISLFLIFIHFFLLFFTHNSDFKHPNFFRICSCYDFLSFTSTKLSSFLFLSHFFYIDSFSFSFSLTFFILILFSFFLSNIDSFSFFSHFFYIDSFSLSFFLTFSILILFLFLSLSLFLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EFF3</accession>
    <name>A0A812EFF3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MED12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_70187</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005136">
        <property type="protein sequence ID" value="CAE1319952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EFF3"/>
    <dbReference type="OrthoDB" id="20828at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1319952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="746" mass="82696" checksum="AB0CEF0B482C56CC" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EH44</accession>
    <name>A0A812EH44_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RABGEF1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SPHA_73567</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005381">
        <property type="protein sequence ID" value="CAE1323695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EH44"/>
    <dbReference type="OrthoDB" id="300289at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041545">
        <property type="entry name" value="DUF5601"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045046">
        <property type="entry name" value="Vps9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101">
        <property type="entry name" value="RAB GDP/GTP EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101:SF122">
        <property type="entry name" value="RABAPTIN-5-ASSOCIATED EXCHANGE FACTOR FOR RAB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18151">
        <property type="entry name" value="DUF5601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00167">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VPS9" evidence="3">
        <location>
            <begin position="126"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="307"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAE1323695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="434" mass="49207" checksum="467D527882708457" modified="2021-09-29" version="1">MFYSESSQDQLTAPKKEARRASLESQQVGGEFTEFLKTIKKPVALDVSKKVRSFNERVQTLTEYSIEELSEMVQDFYQSMSDRFHSNPLYSSCSPETIESLMDYMEKFIMTTLYRSVFCSPHTDDEEKDLAIQTRIRSLHWVSSQMLDMSIAEHEMGVRQLIDQAITDIIEMDAKRAPQDKLACLVRCSKHIFEVLRASKDIPASADEFLPALIYIVLKANPPLLQSNIQYITRFANPSRLMSGEAGYYFTNLCCAVAFIENITADSLSLNPLEFEHYMSGEATPPSRGNEYMCEGMRLMYENLQRVAEMQKRHDKVMAEAMQLQRDVEEFKENFKLEIQKVLERTPLEIKPRKVKVEIDEESEETNKLPPPLIPIQSLVAPTPGGTNLPPCQEPINATLPSPVSSAPSTNVMPASDILAPTVVSLPPEKNMLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EK99</accession>
    <name>A0A812EK99_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_75168</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005453">
        <property type="protein sequence ID" value="CAE1325537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EK99"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1325537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="183" mass="22022" checksum="3810B6E03FBBF84B" modified="2021-09-29" version="1">MQLTYLHLPTYLSIYLSIYLSIYLSIYAVHIHLCIYLCKFIYFICSLSISIYLYLFMHFHIYLSIYLSIYLSIYLSTIYHISINLCIYPCSYLFQSVHYLSIYLSIYLSIYLSLLFIIYLSIYLSIYLSIYIYLFPSVHYLSIYIHIYLFQSKSWAVAEFVNSLSIYLSIYLSIHLSRKYVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EMD1</accession>
    <name>A0A812EMD1_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase A2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SPHA_75838</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005474">
        <property type="protein sequence ID" value="CAE1326245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EMD1"/>
    <dbReference type="OrthoDB" id="6276451at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06094">
        <property type="entry name" value="RP_Saci_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000130">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon opus-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001995">
        <property type="entry name" value="Peptidase_A2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034132">
        <property type="entry name" value="RP_Saci-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38681:SF1">
        <property type="entry name" value="RETROVIRUS-RELATED POL POLYPROTEIN FROM TRANSPOSON 412-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38681">
        <property type="entry name" value="RETROVIRUS-RELATED POL POLYPROTEIN FROM TRANSPOSON 412-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50175">
        <property type="entry name" value="ASP_PROT_RETROV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="396"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="424"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A2" evidence="3">
        <location>
            <begin position="84"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAE1326245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="446" mass="50535" checksum="D10E0BDD5CE20C86" modified="2021-09-29" version="1">MVEAGSLPPAGRPRSSSRNKDALLCVITTADLGLQHITAPSRVYLYCGRGKQNRQRVKATNLAGKAFSPKLSRLFYVTDTRNNLRFLVDTGAAISVLPVRDKARQQPFQLRLQAANGSSINTYGTKSLTLNIGMRRDFTWNFTVADVQMPILGADFLAHYDLAVRMNNHSLTDNLTRLCVLGTYSKLTTTGITVATCHNKEYLDLLNQYQDLLRPAGSIDSTKHQTQHFIKTTGQPVFSRPRRLAPNKLKFAKKAFDDMLREGVIPVTTPPVSSSFIQDLRLKMANLCYTPPRHCPSDIYLPHQLKDCEFVFVRNDSVKRPLTPAYTGPFRVLKRADKYFQIQKGIHTDNVSIDRLKPAFIEKPSSHTASQSTPQVQENFKTPVSLDKPKYTSSVVISYSFFLHHFFLFVFVVYFGYYQARISLYSLFIFSSFLQFFSPPLSLFGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EPY7</accession>
    <name>A0A812EPY7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_78318</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005535">
        <property type="protein sequence ID" value="CAE1328698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EPY7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="325"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="354"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="382"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="413"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="436"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="472"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="511"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1328698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="655" mass="76729" checksum="EFBF472108B07BED" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EQ10</accession>
    <name>A0A812EQ10_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Regulator of nonsense transcripts 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Up-frameshift suppressor 2 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SPHA_79884</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Farmed</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC). Recruited by UPF3B associated with the EJC core at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF3B stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Perinuclear region</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005581">
        <property type="protein sequence ID" value="CAE1330606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EQ10"/>
    <dbReference type="OrthoDB" id="27832at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000014">
        <property type="entry name" value="Putative regulator of nonsense transcripts 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000015">
        <property type="entry name" value="regulator of nonsense transcripts 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000023">
        <property type="entry name" value="regulator of nonsense transcripts 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.80.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039762">
        <property type="entry name" value="Nmd2/UPF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007193">
        <property type="entry name" value="Upf2/Nmd2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12839">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY PROTEIN 2 UP-FRAMESHIFT SUPPRESSOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12839:SF7">
        <property type="entry name" value="REGULATOR OF NONSENSE TRANSCRIPTS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04050">
        <property type="entry name" value="Upf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="MIF4G" evidence="13">
        <location>
            <begin position="22"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="MIF4G" evidence="13">
        <location>
            <begin position="426"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="domain" description="MIF4G" evidence="13">
        <location>
            <begin position="630"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="898"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1107"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="221"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="947"/>
            <end position="964"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00059351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00068726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00080859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAE1330606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1137" mass="132287" checksum="8022F15BF2983DC6" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ERD3</accession>
    <name>A0A812ERD3_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_77722</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005521">
        <property type="protein sequence ID" value="CAE1328164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ERD3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44592">
        <property type="entry name" value="NUDIX HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44592:SF3">
        <property type="entry name" value="SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1328164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="200" mass="22661" checksum="777DE3F43F7C019F" modified="2021-09-29" version="1">MSLHLTDRQTVKDPLSFSLSVSLSLCRIEKYSFFLSLSLTLSLSLSLSLLSRILDAYHPFFLKYIDPKRPVSFSLSFFLSFFLSHSAKLPSLSLPLSPSLSLSLSLSLSLLFILIVGVDLSLSLSLSLSLSLSLSKCDICTLNDFLFLSLSFSFSLSDTRRFSIFLFLCLKYIDNKLLTLTLYFFLSQIYRYSYRLPDAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ESQ1</accession>
    <name>A0A812ESQ1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_78555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005544">
        <property type="protein sequence ID" value="CAE1328982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ESQ1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="307"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1328982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="394" mass="44246" checksum="7F5AFAA0661D23AD" modified="2021-09-29" version="1">MISVYLTSSHFSLLFPIALSIFLSLSHSLSLSLSVCCYLSTYQPVCLSVYLIFSYLSHSLSIYLSIYLSIYLSIYLSIYLLSSIYLSIYLSQSFLLSIYLSIYLSIYLCFFLSIYLSIYLSIYLSIYLSLIFLILLKSYLFIIAFYTLSCFLPPHNTHILLSPLSTSLISLSSSSLHHTHLQSLSYISLSLQISSHLHFLLPLSLFPSFNSLPPFLSHSRHNFSLHSFSLSYSLFFLTIIITIFLSLSLSPLLLSFILSSSLIIILSPAHAHFFSIYCYQTTSFSLFLLFSPHPSSLSLVTADSPKFSFTLSSVILISPTLSLSLSPSLSIYISPHPLSLSSSLYFYFQSVYIIFLPYTLYLPLVPSPIPLSSTLSLSPFFSLSPLSPPSPSHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EVD0</accession>
    <name>A0A812EVD0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cilia- and flagella-associated protein 221</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_78451</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005540">
        <property type="protein sequence ID" value="CAE1328851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EVD0"/>
    <dbReference type="OrthoDB" id="5538672at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097729">
        <property type="term" value="C:9+2 motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003341">
        <property type="term" value="P:cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044458">
        <property type="term" value="P:motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029676">
        <property type="entry name" value="CFAP221"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46500">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46500:SF1">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24771">
        <property type="entry name" value="Ig_CFAP74_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0966">Cell projection</keyword>
    <keyword evidence="1" id="KW-0969">Cilium</keyword>
    <keyword evidence="1" id="KW-0282">Flagellum</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1328851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="182" mass="20524" checksum="845E102E8947309E" modified="2021-09-29" version="1">MATDVARASPLKNSILLDSLQLVEPAETHPPVPNHLLDTKIYRNLGQSKVVAVTPEDVHFAGFQVGKKSVADFCITNVCKDVISINILPPQSKYFKLHYKKPGLMIPGIKLNCQVEFLPVEWRYYYDCVRINCPGEENVVVPIHAYPVMNTDGFPQFYLFPPVPVGERLVGFSYIYHSDSIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812F1N5</accession>
    <name>A0A812F1N5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_81048</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005620">
        <property type="protein sequence ID" value="CAE1331932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812F1N5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1331932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="240" mass="28481" checksum="D44F8702AF6F105A" modified="2021-09-29" version="1">MNNLSIYLSIYLSIYLSITQLVHIHLFISHKFYIYLSIYLSIYIYLSIYLSIYLSMFSYASSTVCSDDHGSLGKDWSTRPLHIDLHHFIYLSIYLSIYLSIYLSIYLSHRGFTSIYLSIYLSIYLSIYLSHSCIISIDLSHSCILSIYLSIYLSIYLSISQLYYIYRFISQLYSIYLSIYLSIYLSIYLSISQRVYIYLSIYLTEGLHLSIYLSIYLSIYLSIYLSISQLYYIYRFISQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AH70</accession>
    <name>A0A812AH70_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000002">
        <property type="protein sequence ID" value="CAE1138177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AH70"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1138177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="205" mass="25012" checksum="C38694424F2A8AC0" modified="2021-09-29" version="1">MFNEVIVSVNNHTKADFSYEELYLFNFHQIIFYLSIYLSIYLSIYLSIYLLRERERERERERERERERLLSFFLSFFLSFFLSFFLSFFLFKSIYLSIYLSIYLSIYLSILPGHRNINFFLSFFLSFFLSFFLSFFLSKSVYLSIYLSIYLSIYLSLTICFLFLFILAPMNQLSILFFYLSIYIYLSIYLSIYLSIIKNVCSIFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ANN7</accession>
    <name>A0A812ANN7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_1856</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000053">
        <property type="protein sequence ID" value="CAE1146473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ANN7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="344"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1146473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="363" mass="43230" checksum="4F039BDCE19DFA35" modified="2021-09-29" version="1">MLVYLSIYLSIYLCSNTIHNLSIYLSIYLSQIASFFLSQIFLSIYLSIYLSIYLRLLLSIYLSISDYFFFLSISDCCYLSIYLSIYLSIYLSIYLSIYLSQIASIYLSIYLSIYLRSHLSIYLSIYLSIYLSIYLSQIISFFLSISDCFYLSIYLSIYLSISDHFYLSIYLSIYHRLLLSFFLSICLSIYLRFFLSIYLSIYLRLFLSFYFRLLLSIYLSISDYFYLSSYLSIYLSQIFFFLSISNFYLLSIYLSIYLSIYLSIYLSIRLFLSFFLSFYFRLSFIYLSQIASFFISIYLSIYLSIYLSIYLSQIASIYLSIYLSIYLSQITSIYLSIYLSISDFSFFLFQIASIYLSFYLSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812APG0</accession>
    <name>A0A812APG0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_3145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000091">
        <property type="protein sequence ID" value="CAE1151396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812APG0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1151396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="168" mass="19935" checksum="7635FEA82368A78C" modified="2021-09-29" version="1">MPLSVYLVVSSYLSIYLSIYLSIYLSTSFSQFMYLSIYLSQSVHVSFYLFRSVHVYPFQSVHISIYLSIYLSIYLSIYLFQSFHVSIYLFQLFYISISLSLFISIYFFHFFFLSFFISYVTSQEFKKHQYIGCGACMTPPPRPIDRFFEIAAPAAFFCTTFAYCHFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AQJ8</accession>
    <name>A0A812AQJ8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_3286</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000097">
        <property type="protein sequence ID" value="CAE1151948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AQJ8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1151948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="209" mass="23926" checksum="A9A56061C6A880EE" modified="2021-09-29" version="1">MLYSIFSYFHLSFLLTDLILLLLIFHSLFFLFPSSSSLTRAYNICHSLPSTHTIRILHLHRQPFCLSSYHCLSPSNNLLALSLSLSLFPSLTFPTSSFSLSSSLFPPSLYFSLNFFFYFTLSISLFISLSLSLSLSLSLSLPLFNLFRVFHSFLLFFKAEMAKKCPLSISHSRCSHSLILSPFLSVFFFQTIPLLSLFSHFPLLLNIFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AT83</accession>
    <name>A0A812AT83_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_4619</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000148">
        <property type="protein sequence ID" value="CAE1155988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AT83"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1155988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="228" mass="27371" checksum="589C3931FEEB5BD7" modified="2021-09-29" version="1">MREAVNNFEAKHRASPEKRRTKQLLTTQTNYFSLLPSSPFLRFLLFLFYSFFFPFPLYCSIYFLFFLLLSLSSISFLFFLFLFCLPLFLFSSSSFFCRLLFLFSSSSFFSLISFSFLSSSISFLFFFFLLSSSISFLFFFFLFSSFFFVVFYFFCLLSFFFFVFLYFFSLLLSFVVFYFFSLLSFFVFLYFFSLLLLLSFVVFCFSSSSSISFLFFLLLLSFVSLFHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AVB9</accession>
    <name>A0A812AVB9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_6210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000203">
        <property type="protein sequence ID" value="CAE1159995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AVB9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="363"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1159995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="427" mass="49838" checksum="BD6E841E6FBF6B32" modified="2021-09-29" version="1">MFVSNRWASLSLNDDTLESVYGHFVQREVDPTNQPTNQSIYLSIYLSIYLSIYLSIYLSQSVHTIYKSVPQYVCLYNSVLYLSIYLSIYLSIYLSIYRLIDRTIYLSLSLSVSCFHLSISFSFYLILFLSLYRCIYLICSCRLPYTFSSYLTFLSITFYRITGFRIPGFYVTFEVFFLYPRNISLILITSVFLPHSLDISLSIGFLFPFYSDSYSLSPIEARLFQGALLFQPAPLVQSVISPCRFLPDCLYISPHTFILHKTFTPALHHALLFHPAFHSSQSTLFFHPILLSTQPVYSRYAYIPPIPFIPPCRFYSIHLVIPPYTSIRSCLFVPPCFSIPFCPFIMSYTFIKTYVLIFHFTRLFYLLFFIQTCVLIPVYLAQPVYYRLPVYSTLLTDSSLLFYSNQLHPAIFMLTYPFIRNSLFIPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B034</accession>
    <name>A0A812B034_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_7815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000254">
        <property type="protein sequence ID" value="CAE1163925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B034"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="392"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="419"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="460"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="495"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1163925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="531" mass="60676" checksum="6F3219C53053DBE6" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B0M8</accession>
    <name>A0A812B0M8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_10607</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000343">
        <property type="protein sequence ID" value="CAE1169427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B0M8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1169427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="176" mass="20779" checksum="5944F88B90F5D3D3" modified="2021-09-29" version="1">MYISIYLHLRSFTFDGIFISIYLSIYLSIYLHLCSFTFDGVFISIYLSIYLSISIYVHLPLTVFPYLSIYLSIYIHLCSFTFDGIFISIYLSIYLSISIYVHLPFFGISSIYLSIYLSIYLSIYLSISIYVYLPLTVFSYLSIYLSIYLSIYLHLCSFYNFLSISIYLSPFMFIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B109</accession>
    <name>A0A812B109_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heme-copper oxidase subunit III family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_8630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000281">
        <property type="protein sequence ID" value="CAE1165939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B109"/>
    <dbReference type="OrthoDB" id="8964431at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000298">
        <property type="entry name" value="Cyt_c_oxidase-like_su3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50253">
        <property type="entry name" value="COX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="311"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="356"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="390"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="Heme-copper oxidase subunit III family profile" evidence="2">
        <location>
            <begin position="17"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1165939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="796" mass="95663" checksum="EDB74279DAB1B6CB" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B123</accession>
    <name>A0A812B123_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_8866</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000287">
        <property type="protein sequence ID" value="CAE1166441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B123"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="228"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="310"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="340"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="370"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="403"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="442"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="534"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="534"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="554"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1166441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="563" mass="64929" checksum="86992874A5F5668B" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B4I8</accession>
    <name>A0A812B4I8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_9934</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000318">
        <property type="protein sequence ID" value="CAE1168250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B4I8"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1168250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="162" mass="18627" checksum="9D959648F9A9E3B2" modified="2021-09-29" version="1">MERSELEQTVHDNRCDEISAMFNMIMDKKRVAKGIFDMDHTAKPDIKPQRKERTGRTKRTRSSLPKPKNTSSPNNKTETNAENLIDGVEPSQQSTSFDFLALCSAPTWLGPGRRRSGRRKSRWPNIISFCLLSLSIYLSIYLSIYLSIYLSIYLSIYLLNFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B4N2</accession>
    <name>A0A812B4N2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_11326</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000374">
        <property type="protein sequence ID" value="CAE1170983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B4N2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1170983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="207" mass="25074" checksum="130CE7A0D3144797" modified="2021-09-29" version="1">MIFTLGRFSWSTSHDVTLDHAKVKTYNLSIYLSIYLSIYLSIYLCIFKKRKRNITKFTLFFLLLLPIPPFSHPVCDLPPRFHFLFFSSSYFTNSFSLSSYTSSSSSSHYLRLFCLHPSFYCCTHYLLLLLLLLLLLLLLLLLPIHLQRPVRRRPSPLPSFFFIFHLFRYQLFVFILFSSYAHFFFFFFFFFFFFFFFFFFFQLSSIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B4S3</accession>
    <name>A0A812B4S3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_10887</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000356">
        <property type="protein sequence ID" value="CAE1170007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B4S3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1170007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="320" mass="38266" checksum="4D04D8567F41720C" modified="2021-09-29" version="1">MYVCVYLSIYLSIYLSIYLSIYLSIYLFFNGSIWFLISIYLSIYLSIYLSIYLSNSLPVYLILALSIYLILALSIYLILSLSISFFPLSILPFYYSQHYLSLIGSIYLSIYLSIFHLSISFSPIYLSIYLSIYLSIYLSNSLHIYLSSYLAHSLPIYLFHSVPFYLHEIFFLPLLSLVFPFFSIYFSSSSSSSFLFSFIVIDTHSLSLYVHCLIFSIFFYIHLLFLLLLAINFILIFFTHSFFSFYFISHSLTLYFHCYFFFILHFSLFFFFFHFNFLYFAYFFIAYISSFFSYFLHFFSFVFFLSSSSYSFFFFILLSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B5P6</accession>
    <name>A0A812B5P6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_9682</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000310">
        <property type="protein sequence ID" value="CAE1167872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B5P6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="319"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1167872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="357" mass="42669" checksum="9DDB385A930C14B8" modified="2021-09-29" version="1">MYLSTSACSLSIYLSIYLSIYLSIYLCSYISKYVSMYLSQSNHIYLPISVSSYLSIIYLLQSVHFYLSIYLSIYLSIYLSIYLSMVHFYLSIYLSIYLSIYLSIYLLIFYKTKPKPNQTSSILVFNISSFPSCNLLFSFSHISLLFLFFFTFILFLFLPVHISFFVLSLIHILFPSTSLFICFLFFVFLSFIFSLCHLLFILALFLFFSLLLFIENRPPYFLFSFFFYIYFFIMSLFLLHLSFILPLFFFLLLIDYLLRFTFSFLHFFNISFPFFFILVSFFSVVFHSFFNLTLFFSLFSFISLPFISRGHNIVSCGHTNIYLSIYLSIYLSIYYYLKIPHNTFYFLYLSLSIYHSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B7M5</accession>
    <name>A0A812B7M5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_12312</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000412">
        <property type="protein sequence ID" value="CAE1172922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B7M5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1172922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="234" mass="28306" checksum="34806620A4C8F583" modified="2021-09-29" version="1">MKRAWLLLLLLLLLRRRRRRRRLLSFFFFLSFFLFYFLIFFLFYFFFLFFFFFLFFFFFFLFFFFFFLSFFFLSLFFPTSFFPSSSSSSFSTSSSSFSSTSFFLSFLPPSFFPPPSSFPSSSSFSSSFFFFLLPFLLFLLLLSFLPSSSFFPSSSSFSSSSSSSFSFPFLLLPSFSYSSSFFFLLHFLLRHLPFLLLLLLLLPSSFSSSSFFILFFVDFLFFFFFFLFFFFFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B7M8</accession>
    <name>A0A812B7M8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_14497</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000495">
        <property type="protein sequence ID" value="CAE1177159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B7M8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1177159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="174" mass="19317" checksum="81EB83DCE9B7E03D" modified="2021-09-29" version="1">MCALKISFFFLLLPMFFLTILFSSLSLSLSLSLSDFSNAASRAHKWRLLLSQFLPLHADVCIQDGLHVKIGRLSATIFARATVILLSVSLARYWTVPPSARQASSRKCTIYPAPLSLSFSFSLSLSLSLSLSFSRLCLRLHSLSFSLFCSLNSTPVKILIIYPRCLLSHITSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B846</accession>
    <name>A0A812B846_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_10937</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000358">
        <property type="protein sequence ID" value="CAE1170125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B846"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1170125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="229" mass="26538" checksum="979C831DF35C4442" modified="2021-09-29" version="1">MGISIYLSIYLSIYLSQPLSIPYLSVPTPLHVIFYLSIYLSIYLSIYLSNLYPFFSIFYLVKMLEEWSISIYLSIYLSIYLSICSNPYLHVSLFILIYQSIYSIFTLILSHSLSLSLSPSSPLALSICSHFSLHKSLFLSIYLSIYLSIYPNLTLSLSLSLYLSIYLFQPLFTCNFLPNLTLSLSFSLSLSTCNRMSNQMMRWIQRNSLSVDDYLSIYLSIYLSLYIYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BA07</accession>
    <name>A0A812BA07_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_12883</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000432">
        <property type="protein sequence ID" value="CAE1173969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BA07"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1173969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="269" mass="32447" checksum="FC12398F3C1456AC" modified="2021-09-29" version="1">MNFRFFFFFSPLFLSFFLLSFFLSCFLFSFSSLSFFLFSFSSLSFFLFSFSSLSFFLSPLFLSFLLSFFFLLSFFLSFFFLLSFFLSFSSLSFFLSPFFLSFFLSFFLSFSSLSFFLSFFLSFFLLYFFLAFFSLSFFLLSFFLSFSYHSFSYHSFFLSFFLSFFLLSFSSLSFFLSFFLSFFSLSFPYAFPFLSLPIDCSLSIAPILYIFSFSSYLFVIFCLYLSFSFFSFSSSFLSLSNDSIRSTFPIRRFFFYFFHFIFFKYRLFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BB49</accession>
    <name>A0A812BB49_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_13642</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000458">
        <property type="protein sequence ID" value="CAE1175410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BB49"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1175410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="153" mass="17488" checksum="45D0EECC01DE4A5E" modified="2021-09-29" version="1">MSCLLDGWTISTVFDYSPPISLSPSFSPHSLSLCLSVFLSISLSLSLYIFSFISLYLSVFLTRSLYVPLSNVFASSLSLSLSLYFCLFSIYLSIYLSIYLSIYLSITPITNTLLMYLSLFHSLFLYVFALWRMIVMLSIYLSIYLSIYLSIYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BEQ7</accession>
    <name>A0A812BEQ7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNF217</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_14275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="2"/>
    <dbReference type="EMBL" id="CAHIKZ030000488">
        <property type="protein sequence ID" value="CAE1176705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BEQ7"/>
    <dbReference type="OrthoDB" id="10009520at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1176705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="240" mass="26333" checksum="8982C8D7E3506B85" modified="2021-09-29" version="1">MNCVKCGTSFCYRCGEAFRSWKAFGDHSSKLSVFGCKYAFLPQKPFCRKLIRGSIFSTRVCAAVFVGTLAIGVGSAAVCVSAAALPFYGAIRLCQKLKRKRRSSIPESVSPTTSPTNCYLIRKIPNISEETEQKGKYLKHPAALINGFLYLKFPPFSPIPLSPLLPSFPPPPLSLPHPIPPPLSPHPSFPSLPIPLPPLSPSLPPLSLSPHPSLLFPSHYLNPYFSNSQTVTFNFPFLFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BGA5</accession>
    <name>A0A812BGA5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_16829</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000596">
        <property type="protein sequence ID" value="CAE1228432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BGA5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1228432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="327" mass="39344" checksum="CB2555F139DE34A5" modified="2021-09-29" version="1">MKTKDERNGEGNERDKSNTYIYLSIYLSIYLSIYLNLLITIYLSLFISFYLSLFISVCLSFYHSLFISLYLMSSYLSLYISVRLSDCLSIYLSIHLFIYLSIYLYVFRYVYVYLILSISIYLSIYLSIYLSIYLSQFVHIYLSICLSVCLLISIYLSIYLSVFLSIYLFSFLYFLSFFLSFFLSFFLSFTSFLSSLLFLSHHFFISDLPFPSFHIFLLSFISFLLFIFNVSFFLHRFSFHRLISFSSIYFFFLSFVFLLLFLYELYFLSFFLSFFLSFFLLSHLFHRMSIYSFLLNILELHVYLIFLRRDVLPSFVTDKHTNLFSPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BGQ9</accession>
    <name>A0A812BGQ9_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">G-protein coupled receptors family 3 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SPHA_16416</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000576">
        <property type="protein sequence ID" value="CAE1227479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BGQ9"/>
    <dbReference type="OrthoDB" id="425344at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000337">
        <property type="entry name" value="GPCR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017979">
        <property type="entry name" value="GPCR_3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050726">
        <property type="entry name" value="mGluR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24060">
        <property type="entry name" value="METABOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01176">
        <property type="entry name" value="GABABRECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00248">
        <property type="entry name" value="GPCRMGR"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00981">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="61"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="10">
        <location>
            <begin position="1"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAE1227479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="254" mass="28755" checksum="A010F76ABD7E38C4" modified="2021-09-29" version="1">MTFLVVSKPNPFTCGAQQFGIGLCFSITYASILTKTNRIARIFRAGKRTAKRPKFISPRSQLFICGSLVSLQLAIGVVWLMMSPPIAIPFYANRNDHQLICKAARGFSYMIGFSYPILLVNICTIYAILTRKIPEAFNESKYIGFTMYTTFIIWLAFVPIYFTTAHNIKVRMATMCVSISLSATVALLCMFTPKLYIILLHPERNVRQSMMASKMMVPKTNSSTARVDSGTQADGTWLSNYFLVFFYFILEKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BHC6</accession>
    <name>A0A812BHC6_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Glycylpeptide N-tetradecanoyltransferase</fullName>
            <ecNumber evidence="2 5">2.3.1.97</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SPHA_16692</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Farmed</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>N-terminal glycyl-[protein] + tetradecanoyl-CoA = N-tetradecanoylglycyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15521"/>
            <dbReference type="Rhea" id="RHEA-COMP:12666"/>
            <dbReference type="Rhea" id="RHEA-COMP:12667"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
            <dbReference type="ChEBI" id="CHEBI:64723"/>
            <dbReference type="ChEBI" id="CHEBI:133050"/>
            <dbReference type="EC" id="2.3.1.97"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the NMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.97" evidence="2 5"/>
    <dbReference type="EMBL" id="CAHIKZ030000591">
        <property type="protein sequence ID" value="CAE1228145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BHC6"/>
    <dbReference type="OrthoDB" id="60315at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004379">
        <property type="term" value="F:glycylpeptide N-tetradecanoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.170:FF:000001">
        <property type="entry name" value="Glycylpeptide N-tetradecanoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000903">
        <property type="entry name" value="NMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022677">
        <property type="entry name" value="NMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022678">
        <property type="entry name" value="NMT_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022676">
        <property type="entry name" value="NMT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11377:SF5">
        <property type="entry name" value="GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11377">
        <property type="entry name" value="N-MYRISTOYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01233">
        <property type="entry name" value="NMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02799">
        <property type="entry name" value="NMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00975">
        <property type="entry name" value="NMT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00976">
        <property type="entry name" value="NMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="547"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="Glycylpeptide N-tetradecanoyltransferase N-terminal" evidence="9">
        <location>
            <begin position="178"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="Glycylpeptide N-tetradecanoyltransferase C-terminal" evidence="10">
        <location>
            <begin position="350"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="66"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="104"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAE1228145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="596" mass="68458" checksum="924FD33B117185D4" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BI70</accession>
    <name>A0A812BI70_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_17838</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000637">
        <property type="protein sequence ID" value="CAE1230649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BI70"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1230649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="164" mass="18653" checksum="4D3270DF3DB0A974" modified="2021-09-29" version="1">MLSILVCPYLSIYLICPYLSIYLFIYLSLSISIYLSILVCPYLFIYLICPYLSILVCPYLSILVCPYLSIYLSLSISIYLICPYLSIYLSLSISIYLSLSISIYLICPYLSIYLSLSISIYLSILVCPYLSILSVHIYLSIYLSLSISIYLSISLSLSISIYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BLM1</accession>
    <name>A0A812BLM1_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dual-specificity kinase</fullName>
            <ecNumber evidence="2">2.7.12.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SPHA_18285</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Farmed</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.1" evidence="2"/>
    <dbReference type="EMBL" id="CAHIKZ030000659">
        <property type="protein sequence ID" value="CAE1231934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BLM1"/>
    <dbReference type="OrthoDB" id="9332038at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd14224">
        <property type="entry name" value="PKc_DYRK2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000112">
        <property type="entry name" value="Putative dual specificity tyrosine-phosphorylation-regulated kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000127">
        <property type="entry name" value="Putative dual specificity tyrosine-phosphorylation-regulated kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.10.30">
        <property type="entry name" value="DYRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042521">
        <property type="entry name" value="DYRK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF112">
        <property type="entry name" value="DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REGULATED KINASE 3 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1062"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="648"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="200"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="414"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="489"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="901"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="961"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="88"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="109"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="149"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="201"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="233"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="427"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="494"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="521"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="560"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="986"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1002"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1020"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="677"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAE1231934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1094" mass="119975" checksum="156B3AAF3AE5A741" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BMI1</accession>
    <name>A0A812BMI1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_20454</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000749">
        <property type="protein sequence ID" value="CAE1236892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BMI1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1236892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="263" mass="31249" checksum="073F84CB484B8812" modified="2021-09-29" version="1">MLRFSFFAFSLFLSFSHQFVSFLSFHYCFSFSLSFFLFIIASFSLFLFFLSFFSLLLLSLSFSFFLSFFLFIIASLSLYLSFFLSFFSLLLLSFSLFLSFHYCFSLSLSFSLLLLSLSFFFSLFLFFLSSFLSFFFSFFLSFFLSSTRVNLLLSVSSFFFLSFLHSFSHLHFFLFISLYFIHSDTYFSSLTSSQYSSIISFFLSFHYCFFLSLSFFLFFFSLLLLSLSFFLSFFSLLLLFSLSLSFFLSFFLSYYLHHVSSYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BNT9</accession>
    <name>A0A812BNT9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_21298</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000780">
        <property type="protein sequence ID" value="CAE1238331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BNT9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="349"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="384"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="443"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1238331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="466" mass="53781" checksum="404C02D5CB089182" modified="2021-09-29" version="1">MFFLLVSRMTDFDKIFATYLSLITASLFRSFFSSSSSSSSSSSSSSSSSSYLHLSVELNHYTNSSFVSLIPPSSSNPFPTPLITFSFACLTWVFCPSILFFIITSSSSLALTRYHEYPSPLIYSTSNSFFSSSLSLSLSLLIFIIYFFLLLLFNILFSLSLLFLSLRINIHFSFNSFLYIPFSFCLHIHSFFFLSFFLSFIHSFFHSFFLSFFLSFILSFFDCFFLAFFLYILSFILTFFLSFFSFHSFFFFLFSFFLSFLFFLSFFLFIFFFLSFFHSFFHSFFHSFFLSFFHSFILSFFHSFILSYIVSFIHSFILSFILSLFLSFILSLVFHYVSEMVFHSSVLHSLCLCLCLSLSLSIYLSIYLSIYLSASVSIVILTQIYRACVSLIPLTFFNSSFFSLVLLCISGISLCLRHDFPFVFSSFSLSLSLSISLSQSLSLSLSLSLSIYLSIYLSASVNTRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BQN8</accession>
    <name>A0A812BQN8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_23480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000868">
        <property type="protein sequence ID" value="CAE1242720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BQN8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="302"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1242720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="332" mass="38323" checksum="8B497E3D2CD654FA" modified="2021-09-29" version="1">MVRFLSFFSLNFGQSALYFSKASCNNICNTTKHNCLFNFAQLTESPLPVLKYFSFPSLSLSPSLSLSLSLCFLYFLASIFQYFSFPVSFFFLYLSLFLTLHMYLSISSSLFLSLSSSHILYRLLSLSPSIYFSISVFNSVFHVVPFYSFFLSFFLSFFLSFFLSFFLSLCLSFPLFRSLCLFLSFSLSFSLSFFFLFLAIALFFFLLIFRSFSLSLSLYLSISLFLFLSLFLSLSLFDFFLSFSLFSSLLFLSDSPFPTFWLTSPNFLHHFFLSVLTSFHPVFIFLSFAIRRFLLPHSRSLSLSLSLSFSLSVSHFTSPFLSVTLILPSSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BQU5</accession>
    <name>A0A812BQU5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_21842</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000802">
        <property type="protein sequence ID" value="CAE1239525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BQU5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="363"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="391"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="423"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="458"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="491"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="518"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="549"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="576"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="601"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1239525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="629" mass="76237" checksum="893F870807FA9C62" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BVE4</accession>
    <name>A0A812BVE4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_27669</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001080">
        <property type="protein sequence ID" value="CAE1251749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BVE4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="393"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="417"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1251749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="456" mass="53650" checksum="9E3437738E9E4D5C" modified="2021-09-29" version="1">MNECFRLFCSLWLLESTSRHFFVTFLNSFPDRNFFLTFLNSLPVRLFFLTFLNSFPDRLFFLTFLNSFPVRLFFLTFLNSFPVRLFFLTFLNSFPVRLFFLTFSIPSLSVSSSSLFLIPSLTVSSSSLFSIPSLSVSSSSLFSIPSPTVSSSSLFSIPSPTISSSSLFSIPSPTVSSSSLFSIPSLSVSSFSLFSIPSLSVSSSLTFLNSFPVRLFFLTFLNSFPVRLFFLTFLNSFPVRLFFLTFLNSFPVRLFFLTFLNSFPDRLFFITFLNSFPVRLFFITFLNSFPVRLFFLTFLNSFPVRLFFLTFLNSFPDHLFFLTFLNSFPVCLFFLTFLNSFPVRLFFLTFLNSFPVRLFFITFLNSFPDRLFFLTFLNFYYDIDLFPFLFPSLLYLFLLFLLLFSFFPFIFPSHFLFIFSFFFHFFFFHFPFFFLFLTITFSLSISSLCKKYEQYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C051</accession>
    <name>A0A812C051_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_26922</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001029">
        <property type="protein sequence ID" value="CAE1250038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C051"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1250038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="168" mass="18682" checksum="E107272E878AB83C" modified="2021-09-29" version="1">MTLVRLFNPDDFVTIYFSDLKCPIRPGMGMMAHYNEVYNNKRQGLLTGQGQSCPIFLILILSLSHSLSLSLLMKIKIFHKYLRALLVIFFLLSLSLSLSLYLSISISLYLSLFNLTPFSSTAHPISYLLFSSRICLVPTTACPLSAASTSDSSFSAPSLIAVLFIEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C216</accession>
    <name>A0A812C216_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_28423</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001113">
        <property type="protein sequence ID" value="CAE1253367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C216"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1253367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="232" mass="26851" checksum="92D62A1E3BD44915" modified="2021-09-29" version="1">MLFSPSHFLSFSLSIYLSIYLSIYLSIYGRYSECTPHLSHPGLCLSLSLSLSLSLSLSQTYTHILPLPSFLPSFLPSFLPHFIYLLPLFLFFASHLSLLYFLFFLSSYYSLFYFASACYLFFLSFLPSSIFICSLNTFLPSLLSLSVFSHILLPLFVYPLYPFSYFPSFSFPVSTYNRFLLSNSTVFFPSIFSLFSLLFLGSFPLYLSFLFFLYLALVFICLSLIWTCYHSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C2S4</accession>
    <name>A0A812C2S4_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein eS6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">40S ribosomal protein S6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SPHA_28321</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Farmed</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001112">
        <property type="protein sequence ID" value="CAE1253227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C2S4"/>
    <dbReference type="OrthoDB" id="10260596at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001377">
        <property type="entry name" value="Ribosomal_eS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018282">
        <property type="entry name" value="Ribosomal_eS6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11502">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01092">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01405">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00578">
        <property type="entry name" value="RIBOSOMAL_S6E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="221"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="347"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="170"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="347"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="369"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="437"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAE1253227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="620" mass="63923" checksum="9BA99BAF04C51608" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C4Z0</accession>
    <name>A0A812C4Z0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_27844</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001090">
        <property type="protein sequence ID" value="CAE1252062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C4Z0"/>
    <dbReference type="OrthoDB" id="7472369at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050972">
        <property type="entry name" value="SDr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34403:SF14">
        <property type="entry name" value="OS05G0225800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34403">
        <property type="entry name" value="TOL-PAL SYSTEM PROTEIN TOLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="361"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="390"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="418"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="444"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="472"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="500"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="522"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1252062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="548" mass="63178" checksum="09BE58F1E598350F" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C5G3</accession>
    <name>A0A812C5G3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_28685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001125">
        <property type="protein sequence ID" value="CAE1253928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C5G3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1253928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="169" mass="18900" checksum="8A667C3BD2A2DD25" modified="2021-09-29" version="1">MSQLYSFKAVEDSFQQPNNNASGDDFMLSQLYSFKAEDSFQQPNNPSETTFVPALFLQGCRRFLSATKWAVKVLSSNQMVVRLSCQLYSFKAVEDSFQQPNGNASERLHVPLLFLQGCRRFLSTTNNNASETTSCPSFIPSKAVEVPFQQPNNNASETTSCPSFIPSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C7I4</accession>
    <name>A0A812C7I4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_29961</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001202">
        <property type="protein sequence ID" value="CAE1255999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C7I4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        </location>
    </feature>
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        </location>
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        </location>
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        </location>
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        </location>
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        </location>
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        <location>
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        </location>
    </feature>
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        </location>
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        </location>
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        </location>
    </feature>
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        <location>
            <begin position="664"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="691"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="719"/>
            <end position="741"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAE1255999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="759" mass="92156" checksum="752C269EF04FC3CA" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C991</accession>
    <name>A0A812C991_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TIR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_30893</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001247">
        <property type="protein sequence ID" value="CAE1257674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C991"/>
    <dbReference type="OrthoDB" id="10037120at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13676">
        <property type="entry name" value="TIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00255">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="391"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="421"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="456"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="483"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="TIR" evidence="2">
        <location>
            <begin position="257"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1257674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="509" mass="58104" checksum="6F981D0DDC2A5765" modified="2021-09-29" version="1">MLLMLIAYAGSYSIAIISVQKYCEDTFQLVSTNTTSAKKDLTTAVMSLRKLDSLLLSTTQGPCEIQLHLGDITKLSVEDKVDLILVSAFPCDYTVASQSLIKSLYVNLGLSVEKLSRDKYMDLRKYYSCWLSKTLPSHLPFARLACFERRGNYVNPIEQIKDMFRAFMPIFNSQDTTVITPLLGAGCQNFDEILVLNTIIEAACNWMRIGLPLRCLKIVLYDKGSSKITAINEKCIGEFAKLKKKWETPLVFQMLKKIHDVYISYSPNDADTAEMLVTHFVTSNKTIKVFSKRIQNKSSKVWPEHIMSAMSGCKRVLVILTSSYLETKDCLDEFNIALCHKRQAKELKLIPLYIQTLLNLPPVISNVQYMDCRLNEGETLSEKLLTVCEKLITELIIAVYIDFGLLVTIDLSMLIHIYLSIYLSIYLSIYLSIYLILSISTYLSILRTSIYLSKPILIYLSIYLSIYLSIYLNLFIISLSKPILIYLSIYLSIYLSKPIHYLSKPIHYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CBM9</accession>
    <name>A0A812CBM9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_31823</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001318">
        <property type="protein sequence ID" value="CAE1259757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CBM9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1259757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="303" mass="35777" checksum="16A09AAA97A72F68" modified="2021-09-29" version="1">MLNASERSCLLTLPLFPTFFNPSCFLSILFGFLFFLLYFIYFFLHFFLFFRYFLSLFLSFITVFYCLLYFFFLSFFTFSFFLYFFFLSLRFFSFFTCFVFLFLVFSFLSFHFFLSFLSFFLVFSFFFVFTFLFCLYFSFFFVFTFLSFFLVFTFLSFFLVFTFLSFFLSFFSFSVRVMLVLNLSSHFSLSLSLSLSLSLSLNIASSIVTDNTDATKTNPDHIPALMSSIYTHLSKSSSLFSPNSSFSKVLSLLLPLTFNLLIHSSIFIVIVFHFFFLLSRVDYGNSCLINSELFFVSSLGKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CCB6</accession>
    <name>A0A812CCB6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_32166</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001335">
        <property type="protein sequence ID" value="CAE1260380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CCB6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134:SF22">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134">
        <property type="entry name" value="OS08G0543275 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1260380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="305" mass="35975" checksum="DB8F4FE3A9D19453" modified="2021-09-29" version="1">MSTSIYLSIYLSIYLSIYLNQIAKFHKFLIYISLTTDVKSIYLVTHLSIYLSIYLSQSVHMYISISVWSYLSIYLSIYLSISVCSYVYIYLSLVISIYLSIYLSIYLSLFICIYLSQSGHIYLSIYLSQSVHMYISISVWSYLSIYLSIYLSIYLSIYLSQSVHMYISISVWSYLSIYLSIYLSIYLSESVHMYISISVWSYLSIYLSIYLSIYLSISPSSFSISFLFPSFSLKHFFSLQISLLSLFNIDLFYFLSSLSFFPPLRFIFSSFFSVSLLFFLFFSPFFLSFFHIYPLSFFVHQRSQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CE16</accession>
    <name>A0A812CE16_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">5-aminolevulinate synthase</fullName>
            <ecNumber evidence="6">2.3.1.37</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">5-aminolevulinic acid synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Delta-ALA synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Delta-aminolevulinate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SPHA_32475</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Farmed</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>succinyl-CoA + glycine + H(+) = 5-aminolevulinate + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:12921"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="2.3.1.37"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from glycine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.37" evidence="6"/>
    <dbReference type="EMBL" id="CAHIKZ030001355">
        <property type="protein sequence ID" value="CAE1260971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CE16"/>
    <dbReference type="OrthoDB" id="10263824at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003870">
        <property type="term" value="F:5-aminolevulinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048821">
        <property type="term" value="P:erythrocyte development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042541">
        <property type="term" value="P:hemoglobin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06454">
        <property type="entry name" value="KBL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000006">
        <property type="entry name" value="5-aminolevulinate synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010961">
        <property type="entry name" value="4pyrrol_synth_NH2levulA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01821">
        <property type="entry name" value="5aminolev_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF102">
        <property type="entry name" value="2-AMINO-3-KETOBUTYRATE COENZYME A LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="4 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="7">
        <location>
            <begin position="213"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU910713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAE1260971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="589" mass="64611" checksum="46ADD5F9809A9F65" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CES1</accession>
    <name>A0A812CES1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="15">EME1</fullName>
            <ecNumber evidence="15">3.1.22.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SPHA_35601</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Farmed</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the EME1/MMS4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.22.-" evidence="15"/>
    <dbReference type="EMBL" id="CAHIKZ030001536">
        <property type="protein sequence ID" value="CAE1267411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CES1"/>
    <dbReference type="OrthoDB" id="343092at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048476">
        <property type="term" value="C:Holliday junction resolvase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.670:FF:000002">
        <property type="entry name" value="Crossover junction endonuclease EME1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.670">
        <property type="entry name" value="Crossover junction endonuclease EME1, DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042530">
        <property type="entry name" value="EME1/EME2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033310">
        <property type="entry name" value="Mms4/EME1/EME2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21077:SF5">
        <property type="entry name" value="CROSSOVER JUNCTION ENDONUCLEASE MMS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21077">
        <property type="entry name" value="EME1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21292">
        <property type="entry name" value="EME1-MUS81_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0469">Meiosis</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAE1267411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="360" mass="41328" checksum="3F3A772D3C85C858" modified="2021-09-29" version="1">MGLEKKLHAKLKAEEKAKQKQERQREREAKRLEKERAIQIKKAQQMSRKAFQPKECLKHMSVILDSAIVSITGLETAIVNICENLGSNYLIQSQKIPFVISWRRSVIECDMGAQVLTAQKDLDEDEILVCLPLDHFVELVYGAKQKQRGEMVADFQTLQGYVDSVRQMYFGCSITLVVIGMENYFRKYKRSKTHKGNRTDTIISRLDVEEALVNLQLRNLCNCQLIESIEDMADIVRTFTKAVAEKPMKKDRLQSEFTFHNEKVGGNASDNQSLWKTQLEQFKNISNDISSAIVSHYPSPKSLVEAYKKCSNEKECIKLLENIMVRRKAGILETSRRVGKEASRRIYLLMTTTNADLVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CHJ3</accession>
    <name>A0A812CHJ3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_34977</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001500">
        <property type="protein sequence ID" value="CAE1266009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CHJ3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="168"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="203"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="267"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="298"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="329"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="402"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="425"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="461"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="493"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="525"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="590"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1266009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="633" mass="72147" checksum="4CB29395A75A6BBA" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CHQ6</accession>
    <name>A0A812CHQ6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_34398</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001458">
        <property type="protein sequence ID" value="CAE1264875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CHQ6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1264875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="218" mass="25526" checksum="2B8A44AA7060BEF8" modified="2021-09-29" version="1">MQKLPGSVNRKKNTRPERLFLSVVCFTFTFLLPFLTCSLFSPLPFPRLLLVSFPPVFVVIASLSIPHKLLSFIASLFFTQFFYPFNEQYVLLHSCLLHLFLFFSAPFYSKYFFFFPKTTPSNFYHYFFFVLIKTVSLLDVICIAYMFVFTCGYTTVSLSLSLSLSLSLSLIIYSLRVYVYVYAVVLVSEVFLMEKNKPYERVLPVCEFYVYNRRVSTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CI35</accession>
    <name>A0A812CI35_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_37427</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001668">
        <property type="protein sequence ID" value="CAE1271833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CI35"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1271833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="263" mass="31888" checksum="C8AD7F4233A9F02B" modified="2021-09-29" version="1">MSTFNTNRPCDPLSVQPLEQSDPQLHLLSVSASWRIYKTDCIIFAFSLSFVLDFFLLCSFFLSFLSFISFFLSFFLSFFLSISFFLSFFLSISFFLSFISFFHFFFSFFLSFFLSFFQFLSFFLSFFHFFLSFLSFVSFFLSFNFFLFFLSFFLSFFLSFFLSFFLSLHHSYFLPTLFFFVFFFFISEILSFFSFINLASFSYYFLSDHFQLFFLSFLVHLIFIYLYLFIFTLLLSFFLSFFLSFFLSFFLSFLLSFFLSLIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CIT3</accession>
    <name>A0A812CIT3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_34970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001500">
        <property type="protein sequence ID" value="CAE1265992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CIT3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="293"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="325"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="354"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1265992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="396" mass="46609" checksum="A505924F8A114C5C" modified="2021-09-29" version="1">MSYTLFVNIALYTRNLSARLTEFNAIQQSLGRAWTKAKNCSRLLCSTHTPDKVPGHSLSLSLSLSLSLSLSIYLSIYLSISREERVQLPGRSLEVFYLSPELFLTIHLFSLSLSLSLSLSLFLHPPYPHFTHDYSFSLSIYLSIYLSIYLSIYNLLSIDKLLSISSYLPLLFHYLSIYLSIYQYGCLSIHFHFLSVYQSISVHIYLPIPFLSIYLSIYLSIYLYIYIYIYIYIYIDVYDFSLSIYLFIYLSIYLSITFSLSIYLSIYLSIYLSNLNLFKKNPTTRENFTALPFSFLSLFLCFFSFFLSFFLSFFLSFFLSFFLSPFYSFIFLITHTLSLTWFSSTLQLINKYSFFLSFFLSFFLSSILSFFLIIFLIFHSFFLFLSFLNSLFFLSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CK66</accession>
    <name>A0A812CK66_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CD109</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SPHA_37115</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001646">
        <property type="protein sequence ID" value="CAE1271171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6359008at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004866">
        <property type="term" value="F:endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.130.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1930">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.690">
        <property type="entry name" value="Alpha-macroglobulin, receptor-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009048">
        <property type="entry name" value="A-macroglobulin_rcpt-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036595">
        <property type="entry name" value="A-macroglobulin_rcpt-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050473">
        <property type="entry name" value="A2M/Complement_sys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011625">
        <property type="entry name" value="A2M_N_BRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011626">
        <property type="entry name" value="Alpha-macroglobulin_TED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001599">
        <property type="entry name" value="Macroglobln_a2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002890">
        <property type="entry name" value="MG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041555">
        <property type="entry name" value="MG3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001134">
        <property type="entry name" value="Netrin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412">
        <property type="entry name" value="MACROGLOBULIN / COMPLEMENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412:SF166">
        <property type="entry name" value="NTR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00207">
        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07703">
        <property type="entry name" value="A2M_BRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07677">
        <property type="entry name" value="A2M_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01835">
        <property type="entry name" value="MG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17791">
        <property type="entry name" value="MG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07678">
        <property type="entry name" value="TED_complement"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01360">
        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01359">
        <property type="entry name" value="A2M_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01361">
        <property type="entry name" value="A2M_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49410">
        <property type="entry name" value="Alpha-macroglobulin receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50189">
        <property type="entry name" value="NTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032644618" evidence="2">
        <location>
            <begin position="21"/>
            <end position="1427"/>
        </location>
    </feature>
    <feature type="domain" description="NTR" evidence="3">
        <location>
            <begin position="1281"/>
            <end position="1422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAE1271171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1427" mass="165136" checksum="44F2C50DD40AD82E" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CKK8</accession>
    <name>A0A812CKK8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_37079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001642">
        <property type="protein sequence ID" value="CAE1271028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CKK8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1271028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="211" mass="24106" checksum="F3260A4E19E69144" modified="2021-09-29" version="1">MLSRRLSSNVSFASRVSARYPVRSSVQLFSLLRDYSNVGDVGLDEVFETITRIILINCLTKFLFFSLFFSLPLNSHSLSLSLSLSLSLSTYITIYLSLSPAFYLFRFFSSLLFYFISLSILSMTIQLKLQFTFPSLSLSLSLSIYLSIYLSISLCHSPYLSLSLSLSHSYGLTPLLFVPFPRKVPLNRPKIWQQKHQLCHHDALDFQLKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CPI1</accession>
    <name>A0A812CPI1_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SPHA_41023</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Farmed</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the N-CoR nuclear receptor corepressors family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001957">
        <property type="protein sequence ID" value="CAE1278048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CPI1"/>
    <dbReference type="OrthoDB" id="6040932at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034967">
        <property type="term" value="C:Set3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16449">
        <property type="entry name" value="RING-HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051571">
        <property type="entry name" value="N-CoR_corepressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13992">
        <property type="entry name" value="NUCLEAR RECEPTOR CO-REPRESSOR RELATED NCOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13992:SF39">
        <property type="entry name" value="SMRTER, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="769"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="820"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="867"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="378"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="21"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="135"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="160"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="183"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="207"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="239"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="255"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="290"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="330"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAE1278048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="898" mass="102323" checksum="BABBEF6C2F37E532" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CPI7</accession>
    <name>A0A812CPI7_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7041 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_37649</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001680">
        <property type="protein sequence ID" value="CAE1272309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CPI7"/>
    <dbReference type="OrthoDB" id="6159822at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055469">
        <property type="entry name" value="DUF7041"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327">
        <property type="entry name" value="ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327:SF3">
        <property type="entry name" value="RNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23055">
        <property type="entry name" value="DUF7041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7041" evidence="1">
        <location>
            <begin position="230"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1272309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="468" mass="53356" checksum="62FC0A15802EFA22" modified="2021-09-29" version="1">MLLELGSSRRFPSGSKSREIEAVAQCLQGAFKAQCLPGAFKAQCLPGAFKAQCLPGVFKAQCLPGVFKAQCLPGAFKAQCLPEVFKAQCLPEVFKAQCLPGVFKAQCLREAFKAQCLPEAFKAQCLPEVTSIHRDLEPHHSYIRKVETLIRREREQRQADIKATRTVSSTHTPRGFSGSHNRQYHVSVNILSPSLSLISLATHSPTFPSHIPSSFLFFFLPQLYGQFHFALFDAKRITSQRTRYCYLVEKLPADIVEEVMDLLENVPDDNPYDRLKEAILKRTGASNEAMLRNLFTQVELGDRTPSQLLRHMRTLLGDNKMSENIMRSLWLDKLPTTTTQILAPMTEETQTEKLVDIADRIHESFRSRRVNSIQPQPAQQRDREFNDLKSTVERLSIQLQGLLQKDRQYRRDKCPGYRKRSFSRGRTDNRNRKDEICYYHKKFGPEARRCTHPCSFNNANAGNGNSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CQ84</accession>
    <name>A0A812CQ84_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_39713</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001865">
        <property type="protein sequence ID" value="CAE1275902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CQ84"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1275902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="266" mass="31714" checksum="6656C0932814726F" modified="2021-09-29" version="1">MSIDERISIKDSSCFCPPATIPAFTIFILSFSVICRHILSIYFSPFVFFLTLTIIIVSSYLLSVSLSLSSIPYYMFEIRKFIHPSLTFSLTLFFFRSFFLGIIFIFIFTLPLFLFYLSSRSSFSFFLFSHYYYIFLSSYLLSFSFSHSLSSLPYCMFEIRKFIHDSISYLHSFFSFFLSSFLSFSLLIYFFSSSYSISLFSLFSFFHYYMFEIRKFIHLYLTFLFGLIFLSFFNSLILSFFLSFFNSFFLSFFNSFFNSFFLSLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CQI4</accession>
    <name>A0A812CQI4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_38104</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001724">
        <property type="protein sequence ID" value="CAE1273389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CQI4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1273389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="268" mass="32734" checksum="73904D7B71B89427" modified="2021-09-29" version="1">MRNKIIRRLKISFFFLRETFSFFLCTFFLSFFHSCFRFCQGEHFNQGFRAFFLSYIFYFSFLQILFFFLSFFLSFFLLLNDFLYICLSLVHCLFFLSFFLYFLLVVFLLTRTLSLFSFFLSFFLSFFLSFFLSFFYLYFHAVFQFLSFFSLSLSFRFSFSLVSPVDFSILCIPLSFFLSFFLSFFLSFFLSFIAAFFFFRKNVLTRDFALSFLDILFFFLSFFLSFFLSFFLSFFLSFTKRLSLFLSFFISLSFLSLIFLYFLLALFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CQI5</accession>
    <name>A0A812CQI5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_41725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002013">
        <property type="protein sequence ID" value="CAE1279207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CQI5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1279207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="249" mass="29217" checksum="2C4B929210EBCA5A" modified="2021-09-29" version="1">MFSFSHLFFPLFFFLRTATTETTELAFLSFFLFFLSALPCYLTALSFFLSFFLSFFLLLSALPCYLTALSFFSFPPFLLFLSFFLSFFLSFFLLLSALPCYLTVLSFFLSFFLSFFLSFFLSSPFRPSLLLDILFLSFFLSFFLSFFLLLSALPCYLTALSFFISFFLSFFLSFFLSSPFRPSLLLDSSFFFFFLSFFFLSFLFLSFFLLSAVPCYLTALSFFLSFFLLLSALPCYLTVLSFFFSFFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CS45</accession>
    <name>A0A812CS45_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_43837</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002223">
        <property type="protein sequence ID" value="CAE1283045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CS45"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1283045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="276" mass="30318" checksum="D9694DB52C8073AA" modified="2021-09-29" version="1">MTNDLKHLFTVFLSLPSYTPSVSPALSLSHLLSQILPLSYPFSPNISPSLCLANLRSLTLSLILSSFLFPSLSLYLLPQCILLNKQSLFLSRSLSLSLSLNRFLLLLSFLTLSLSLSPSLSLIHSYLVTPSRSLTLSHSLLVWFFLLLNHFFSYALSLLSPLPHLSLSLSLSIAFSYSLAFSPLSLSLSLSLSPLSLLSLFPSYSLQIPYSLSLSIGLVLLNHFLSYALSPPLSLSLSILPLSLSLSLALLFHSLSLAISHPHSHFFIFSPSFYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CTW8</accession>
    <name>A0A812CTW8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_40549</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001916">
        <property type="protein sequence ID" value="CAE1277287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CTW8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="264"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="309"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="373"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="401"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1277287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="434" mass="52241" checksum="C2FCC2D729D87CCF" modified="2021-09-29" version="1">MQSFFYSPSLSVSPSLSPPLSPSLSLPLSRFSPCRYAKLGQNRASTRCRQEREAVFALLIYLYSVSALGRFNFFWRGLYVHEKRTENRISISFYLAPSLFLSLSLSLSIYLSKPSSHSLSTCCLSFFLASLLSLLIVSFFLSFFLSFHLRILSFFLSFFLSFHLLILSFFIYFHLPILSFFLFSFFLSFFLSFYCVRFIAFFLSILSFFLYSLSFSFFLYSFFLSFFLSFFLSFHRPILSFFFSFFLSFFLSFFLSFHRPILSFFLSFLFFFLSFFLFIFAFFLSFFLSFHLLILFFKQIYFSLSILSFFFFLSFSFFLSFYCVRFIAFFLSILSFFLYSLSFSFFLYSFFLSFFLSFFSFFFLFIVPFFLSFFCFLSCFLSFFLSFFLSFLFFFHSFFSFFLSFFLSFFSFFLSFFFLSFFLSFFFFFVSIAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CV45</accession>
    <name>A0A812CV45_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="16">EGR1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SPHA_42619</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the EGR C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002090">
        <property type="protein sequence ID" value="CAE1280833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CV45"/>
    <dbReference type="OrthoDB" id="8197458at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000092">
        <property type="entry name" value="Early growth response protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF60">
        <property type="entry name" value="STRIPE, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="474"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="504"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="532"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="162"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="399"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="552"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="162"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="174"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="212"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="235"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="418"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="434"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="552"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="565"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAE1280833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="618" mass="66849" checksum="0737E2E69CFC9C72" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CVQ5</accession>
    <name>A0A812CVQ5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_42809</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002112">
        <property type="protein sequence ID" value="CAE1281358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CVQ5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1281358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="236" mass="28418" checksum="A18229BD4C9C2FB5" modified="2021-09-29" version="1">MPSCFIHLFNEFLFSFFLAFQCLLLISFLFYFFPYSLLRYFFPFMCFLFYFTIFSFFTSLFVTFFAFRFIFSFFRLFLGSFVLSFYLYISFSSILYFLSFFPIFQNFYFLFFLHLSFSIIDSFSILFLFSLHLSLSLSLSLIPLFILLYFFFSTPYRISPSTIICYHFTLIFLEDKHLLYSLVRLSLFFTASCPKANNSRYLSMLFPPKHSVNSSPFQLFSLCENVTKNKSRHTCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CWJ0</accession>
    <name>A0A812CWJ0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HSPA4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SPHA_42264</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Farmed</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002057">
        <property type="protein sequence ID" value="CAE1280307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CWJ0"/>
    <dbReference type="OrthoDB" id="434160at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000004">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000495">
        <property type="entry name" value="Heat shock protein 4b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639:SF4">
        <property type="entry name" value="HSC70CB, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639">
        <property type="entry name" value="HSC70CB, ISOFORM G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="384"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="657"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="391"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="414"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="661"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="676"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="698"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAE1280307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="707" mass="80798" checksum="4ECC3ACC68DCE000" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CWV3</accession>
    <name>A0A812CWV3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_41344</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001979">
        <property type="protein sequence ID" value="CAE1278511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CWV3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1278511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="185" mass="22562" checksum="595C4694F7CD291C" modified="2021-09-29" version="1">MRPAESCYAVLFFDFLLSFFRIFFLFLSFFLSFSTFFSLIFFLSFFLSFFLFLFFILSSLVLFFDFLSFFFLSFFLSFFLSFFLSFFSLIFFLSFFLSFFLSFFLSFFLLLPSLYQFFHSFSFPFFILSSFSFLSYMTFSFQFFLLFLLFFSLFTVDTIMATSLKIFFSLHLPLIIFLFFHSQYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CXX2</accession>
    <name>A0A812CXX2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_43515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002188">
        <property type="protein sequence ID" value="CAE1282533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CXX2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1282533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="179" mass="21356" checksum="87D9FB2B7541D303" modified="2021-09-29" version="1">MARHILSILFSFFFSFFYLSFYFSQSLFHYVLFSAARPLYLCLFFSFSFFQTTFSVYLSKISGSFFSISLLNSLFEHNFYLFLSLYLCLFLFVSFSFFLIIISLSFDFRILNIFFLFLSILSFYEAHNIYISHFELNSFSLSISPFSQDYLYQNDIYKRKGCFNFGFSCRKGTKNIHPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CZK5</accession>
    <name>A0A812CZK5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_42639</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002091">
        <property type="protein sequence ID" value="CAE1280970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CZK5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="382"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="507"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1280970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="544" mass="60507" checksum="75AFE432092EEB91" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D0A4</accession>
    <name>A0A812D0A4_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SPHA_45044</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002322">
        <property type="protein sequence ID" value="CAE1284957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D0A4"/>
    <dbReference type="OrthoDB" id="9942268at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052223">
        <property type="entry name" value="Actin_Cytoskeleton_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17271">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17271:SF1">
        <property type="entry name" value="PROTEIN OUTSPREAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="436"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="470"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="496"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="173"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAE1284957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="514" mass="57859" checksum="AE88BDC63AEDD36C" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D0N2</accession>
    <name>A0A812D0N2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_47209</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002547">
        <property type="protein sequence ID" value="CAE1288612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D0N2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="318"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="370"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1288612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="412" mass="48162" checksum="93F352E9CE2CADE5" modified="2021-09-29" version="1">MHRTLVTCLISMEFDCWLVARRQLQMGTSLFIISIYLSIYLFDLSISVSSYLSIYLSIYLSIYLSIYLSISVCSYLYSSIYLSIYLSIYLSIYLSSIHMYLYLLNLSIYLSPFISSYLGLFIYLSIYLSIYLSIYLSIYLSIYLYLFLFLKSIYKSIFISRVVYLSIYIYLSIYLSIYLSIYLSIYLSMFLSQLYLISSYLSIYLSIYLSIYLSIYLSIYLSLSVPISAYLSLFISRVVYLSIYLSIYLSIYLSISIYLSIYLSIYPFSSISACSSSLFISRAVYIYLSIYLSIYLSIYLSIYLSFNHIYLSEPVHISIIYLSIYLSIYLSIYLSIYSSIYLSLFISIYLSIYLLLILSQIYISLFISRVVHLSIYLSIFSIYLSIYLSIYLSHSVHICLSTVMSTSSALRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D2M0</accession>
    <name>A0A812D2M0_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Flavin-containing monooxygenase</fullName>
            <ecNumber evidence="8">1.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SPHA_47630</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Farmed</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the FMO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="8"/>
    <dbReference type="EMBL" id="CAHIKZ030002597">
        <property type="protein sequence ID" value="CAE1289372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D2M0"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000138">
        <property type="entry name" value="Flavin-containing monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00370">
        <property type="entry name" value="FMOXYGENASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0274">FAD</keyword>
    <keyword evidence="3 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAE1289372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="269" mass="29937" checksum="291729F9C1248C71" modified="2021-09-29" version="1">MKNIAIIGLGAAGLCALRHLAARPNFFRAVGFEQSSQVGGTWVYTPEVRTDKNGISIHSSMYKNLRTNLPKEVMAFPDYEFKKSLPSFIEHFHVKEYLQDYAEHFGLFSHAKLETQIQHVEPLPSTNAGSVGWRITYKNMQSSAASETEDFDAVIVCNGHYSIPNIPQIPGLNKFKGSTMHSHDYRQPEPFEGKTILCLGAGASGIDIAIDLSSVARKIYLAHNKEQLTSEMPSNLVQATGINHFSEDYSLMGVSILFLNTLSMHHILH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D3X8</accession>
    <name>A0A812D3X8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">HCRTR2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SPHA_45619</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002357">
        <property type="protein sequence ID" value="CAE1285782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D3X8"/>
    <dbReference type="OrthoDB" id="6157309at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF208">
        <property type="entry name" value="PYROKININ-1 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="31"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAE1285782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="346" mass="39074" checksum="B927C9DC51255B51" modified="2021-09-29" version="1">MSLSDLNDERVLVGIPAIIYIGVLMIIGTIGNVIVCYVFGFRMRKTTTNCFIITLGIFDLLCCCIGMPTELLDLRYPYMFPSDLLCKMLRFITFLTNGASSLILLVISIDRYRRVCHPLKVQISPKLARKISAVTTVIAAVLTWPTLVIFGIRTTPTRFGFVNGSDCSIADNMKNTLYPSLYYFSILGIILMSFVFMIICYSLIWRQVWRRSRGQIPGENSTRDEEKLSVRRVTKPRAMGKTNMTVFLVTLLFIISFMPGLSVRIIEAIKKFSKSSTPTISSIKKLVLRSYFLSNALNPVIYGFCNESFRNEVRILIRKMKKGCCGKDDSKLPSVTNSVNMSGRIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D6C5</accession>
    <name>A0A812D6C5_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Lysine-specific histone demethylase</fullName>
            <ecNumber evidence="21">1.14.99.66</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">SPHA_50700</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="25">Farmed</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21">Histone demethylase that specifically demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20 21">
            <text>N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + 2 A + 2 H2O = L-lysyl(4)-[histone H3] + 2 formaldehyde + 2 AH2</text>
            <dbReference type="Rhea" id="RHEA:60244"/>
            <dbReference type="Rhea" id="RHEA-COMP:15540"/>
            <dbReference type="Rhea" id="RHEA-COMP:15547"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
            <dbReference type="EC" id="1.14.99.66"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 21 22">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 21">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 21">Belongs to the flavin monoamine oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.66" evidence="21"/>
    <dbReference type="EMBL" id="CAHIKZ030003006">
        <property type="protein sequence ID" value="CAE1295017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D6C5"/>
    <dbReference type="OrthoDB" id="9982100at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140682">
        <property type="term" value="F:FAD-dependent H3K4me/H3K4me3 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032454">
        <property type="term" value="F:histone H3K9 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043426">
        <property type="term" value="F:MRF binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061629">
        <property type="term" value="F:RNA polymerase II-specific DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140861">
        <property type="term" value="P:DNA repair-dependent chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045597">
        <property type="term" value="P:positive regulation of cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051240">
        <property type="term" value="P:positive regulation of multicellular organismal process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000179">
        <property type="term" value="P:positive regulation of neural precursor cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050767">
        <property type="term" value="P:regulation of neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000027">
        <property type="entry name" value="Lysine-specific histone demethylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000029">
        <property type="entry name" value="Lysine-specific histone demethylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.660.10:FF:000001">
        <property type="entry name" value="Lysine-specific histone demethylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000064">
        <property type="entry name" value="Lysine-specific histone demethylase 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.80:FF:000002">
        <property type="entry name" value="Lysine-specific histone demethylase 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.80">
        <property type="entry name" value="ATP synthase, gamma subunit, helix hairpin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017366">
        <property type="entry name" value="Hist_Lys-spec_deMease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007526">
        <property type="entry name" value="SWIRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF386">
        <property type="entry name" value="LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04433">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038051">
        <property type="entry name" value="Histone_Lys-demethylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50934">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0007">Acetylation</keyword>
    <keyword evidence="13 21" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="11 21 22" id="KW-0274">FAD</keyword>
    <keyword evidence="10 21" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="19 21" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15 21" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 21" id="KW-0678">Repressor</keyword>
    <keyword evidence="18 21" id="KW-0804">Transcription</keyword>
    <keyword evidence="16 21" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="12" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="SWIRM" evidence="24">
        <location>
            <begin position="193"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="46"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="47"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="81"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="133"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <begin position="300"/>
            <end position="328"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <begin position="351"/>
            <end position="352"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="829"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <begin position="838"/>
            <end position="839"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00052817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRNR" id="PIRNR038051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRSR" id="PIRSR038051-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="CAE1295017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="875" mass="96961" checksum="F867BCC5D2B5DB9A" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D7Y3</accession>
    <name>A0A812D7Y3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_49117</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002778">
        <property type="protein sequence ID" value="CAE1292129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D7Y3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1292129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="316" mass="37224" checksum="3C5BD7D1B1268A3F" modified="2021-09-29" version="1">MKLRVLQIRPNLLWIRKSSDDVPFSVSLIGAKFDSLSYRRKVDLLVGIAPFPEVEGASLRVERVECDVNIAVAIYILIYFSPTSYLSIYLSIYLSIYLSIYLSIFSLSVGYNNIENGYLYLGPDSDNQHLSRPDFVILSNNIYLSIYLSIYLSIYLSSWIYDIFYNIGIDVLDSLITVKKILISQCIYLSIYLCSHQTSFFPFFYHSMHIRLYPNLFFRPVDFFLSFFLFFGNIYLSIYLSIYLSIYLSIYHVLSINFFVFHIIDSLFFDKMPFFHRGLLFLYPYLRVVNNNFWAPKVFSFQENKGYIMMLHRIPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DBX7</accession>
    <name>A0A812DBX7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_50186</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002933">
        <property type="protein sequence ID" value="CAE1294016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DBX7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="43"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1294016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="198" mass="23312" checksum="A731495DEEC8111C" modified="2021-09-29" version="1">MLDLGIVRPSSSPSASPLHMVPKTLSGTHTHTYIHTFSLSLSFFLSFSLSFFLSIYLSIYLSLLLYLFHRTDCISRLLPLFIHFSQFLSDRFLTSFLFLNSLALFSLNSFLSFFLFFFLIFSLFLHIFRHSILFLFNVCTFFLSFLFHSTTTTSTSLFTHLLRPSHFYFSHSQVVFLSFYFFFFTLLNFIFILPFSSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DDD7</accession>
    <name>A0A812DDD7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_51683</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003142">
        <property type="protein sequence ID" value="CAE1296770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DDD7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1296770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="264" mass="30531" checksum="C3B66FE6F0F8C260" modified="2021-09-29" version="1">MRRDHIILCLFLSFFLSFFLSFFLSFMFISLSLSYLTPSLFLSLSFSSVYVSLYLSIYLSIYLTFFISICHSLFCLSLIMLFCSSYSLIPSLPLSLYLSHLFHVSFFHFTLSFSLSLSLSLSIYPCLSISLCHSVHIYLTFISLYIILSNSPTLSIYLNYFVYLSVSFCSSYSLIFSSLSLSLSFSLSIYLSIYLYQFLHIYLPVIIHIYLIVILSLPQHSLSLSLFIYLTLFICIYLSLCLGLPSCLYLSIYLSQNVHFLFVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DDL8</accession>
    <name>A0A812DDL8_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Helitron helicase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_51777</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003164">
        <property type="protein sequence ID" value="CAE1297012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DDL8"/>
    <dbReference type="OrthoDB" id="1728974at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786:SF74">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786">
        <property type="entry name" value="DNA BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helitron helicase-like" evidence="1">
        <location>
            <begin position="176"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1297012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="590" mass="67417" checksum="224C9F8B9D1A7607" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DF06</accession>
    <name>A0A812DF06_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_54093</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003474">
        <property type="protein sequence ID" value="CAE1300780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DF06"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1300780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="220" mass="24696" checksum="19F6C340E1840C01" modified="2021-09-29" version="1">MSLSLNILTHFSISYIISNSLSLSQTHFLFRVSLSYKLAISLLLYLPFGLFLSLSLSLSLSLYLAHIFSLSLSGTHSLSPSPNLSLVLFTSISFPSFVIIITLFASFRFLSLSHFPVSPSPYVYFYVFFSISLSAFNTSQLSLSLSLSLSLIIYLSIYHTLSKQIQTLKNPFICLSCESCLACCKSKTRTPDITLVFIFHFFTFHECMAVTNFSLFTRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DH10</accession>
    <name>A0A812DH10_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_51650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003142">
        <property type="protein sequence ID" value="CAE1296763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DH10"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1296763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="281" mass="34296" checksum="E19D2EA9127CEC83" modified="2021-09-29" version="1">MLCNSFRLSRWVGDLKLLEREKRMLLLERLEELERDKTFTTGCFCNWMFSSSLTDFRFAFLLLLLLLLLLLLIIIIIIIINIIIILLLLFLLSSSSFLFFFFFFLILLLLIILILSFSSSSSTSFLSFFLLLSYTSYYYPTSSFFFFYFFFFFFFFFFFFFLLLLFILLFSSSSSSSYYYYYPSSSFSSFFIFFSLLFLLLSYTFTSYYPNSFFFFFFFYFFSLLFPSSFLYFFLLLSYFFFLLLLLLFLLLLLLLLSSTSFYSPFLFFFFFFFFFSGYYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DI52</accession>
    <name>A0A812DI52_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_52721</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003316">
        <property type="protein sequence ID" value="CAE1298686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DI52"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1298686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="196" mass="23257" checksum="6FB4AF3D9DEF9C59" modified="2021-09-29" version="1">MSTSDHSHLSVDPCLWSSSLLKSACRSLKKSNLLCLSVDYLKTFLISFYSLSFSPFFPFPFSPFFPFPLSRFFPFPFSLFFPFPFSPFFPFPFSLSFSLLSFLFPSLFPPLFSPTKNPLFLFPFLFSPFLFFLSFLFSNSFFPFFPLLSFRFFSFLSFFFFSTFSFSLLFFLFQFFFSSLFFPFLFPLFLFLHSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DI61</accession>
    <name>A0A812DI61_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GidA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SPHA_53449</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Farmed</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003402">
        <property type="protein sequence ID" value="CAE1299818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DI61"/>
    <dbReference type="OrthoDB" id="3329at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000082">
        <property type="entry name" value="protein MTO1 homolog, mitochondrial isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002218">
        <property type="entry name" value="MnmG-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040131">
        <property type="entry name" value="MnmG_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806">
        <property type="entry name" value="GLUCOSE INHIBITED DIVISION PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806:SF0">
        <property type="entry name" value="PROTEIN MTO1 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01134">
        <property type="entry name" value="GIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MnmG N-terminal" evidence="4">
        <location>
            <begin position="30"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAE1299818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="307" mass="33300" checksum="C9C1E1A4DEED20A6" modified="2021-09-29" version="1">MRLSSCRKLINSQTHSLATQILSSSSCGYDVIVVGGGHAGTEAAHAAARMGTNTLLITHKINTIGAMSCNPSFGGIGKGHLMKEIDALDGLCGRACDETGVQYRMLNTKKGPAVWGPRAQIDRALYKSFIQQELLNLPFLTIMESPVEDLLLKEAMKPDHKLMQQECYGVILGNGQKIFGKSVVLTTGTFLHGCITIGLKSRPAGRVGDEPAIGLAKSLENAGFKMGRLKTGTPPRLDGGTIDYTKMTVQLGDNPPKPFSFLNKNVWIKSEDQLPCHITYTNEKVAKIAMDTLHLNKHVREEISGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DIR9</accession>
    <name>A0A812DIR9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_54952</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003632">
        <property type="protein sequence ID" value="CAE1302383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DIR9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1302383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="209" mass="24553" checksum="35B166895BCA12AC" modified="2021-09-29" version="1">MKSFFFFFVFYLFVTKTICISIYLSIYLSIYLSISVFVHIYLSIYLSIYLSIYLSNKGCLCIYVSTSASEYACAVNTLRLTHLLGFFYLLSKTTPASFSAIFLSFFCRDIYFRLVSLLKHVPSIFFDDKYIDFKSSLFLKFLSFLVPILVFYITYLRILILLPFVHATFPDSRPLISFLKSLLHFFFVVSLFRFRHLSLLLLMALFILP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DIY1</accession>
    <name>A0A812DIY1_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">type I protein arginine methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.319</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">SPHA_54463</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">Farmed</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48096"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11991"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61897"/>
            <dbReference type="EC" id="2.1.1.319"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:48097"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-arginyl-[protein] + S-adenosyl-L-methionine = N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48100"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11990"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65280"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:48101"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.319" evidence="3"/>
    <dbReference type="EMBL" id="CAHIKZ030003537">
        <property type="protein sequence ID" value="CAE1301537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DIY1"/>
    <dbReference type="OrthoDB" id="7848332at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035242">
        <property type="term" value="F:protein-arginine omega-N asymmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000034">
        <property type="entry name" value="Protein arginine N-methyltransferase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049482">
        <property type="entry name" value="ANM3-like_C2H2_Zf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055135">
        <property type="entry name" value="PRMT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006:SF53">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21137">
        <property type="entry name" value="ANM3_C2H2_Zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06325">
        <property type="entry name" value="PrmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22528">
        <property type="entry name" value="PRMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15 18" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7 15 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Protein arginine N-methyltransferase 3-like C2H2 zinc finger" evidence="16">
        <location>
            <begin position="63"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Protein arginine N-methyltransferase" evidence="17">
        <location>
            <begin position="367"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF21137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF22528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CAE1301537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="535" mass="60203" checksum="15F0D11B7EA68263" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DRD7</accession>
    <name>A0A812DRD7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_57778</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003908">
        <property type="protein sequence ID" value="CAE1305276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DRD7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1305276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="182" mass="21138" checksum="86FC9F99FFE456F7" modified="2021-09-29" version="1">MLCSYLSIYPSLSVYIYLSILVCSYLSIYPSLFVSIYPSLFISIYLSYLFISIYLSIYLSIYLSIYLDLFVSIYPSLFISIYPSLFISIYLSIYLSIYLSIYLSILICSYLSILVCSYLSILVCSYLSIYLSIYLSIYLDLFVSIYPSLFVSIYPSLFISIYLSIYLSIYLSIYVVEKCVHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DRP4</accession>
    <name>A0A812DRP4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_59443</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004115">
        <property type="protein sequence ID" value="CAE1307405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DRP4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1307405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="291" mass="35600" checksum="B2136F62F0DD756E" modified="2021-09-29" version="1">MIHKCWKIYLKLHVCFYFYWRQFKFIFFFFVFFFFFVSFFCFFLLSVMTCSLLFFFIILLNILLPFFSLGLSFFFLFRSFQAYSIFSLTLFSFFLSFVLINESLLYPEHIFFFHVEFMYFFQSFSYFSFSSFCLSLSFIFFLSYLLLFKHFSFFFLSFIFIILFNRQYLILASIAFSYMFCLSFIFPISFVSAFFSLFPFFHSFLLYLLHLILHEIYLPLLIIHYLSIYLSIYLSIPINIYLCHPVNIYVIMLISIYLSIYLCHYVNICLCHYVNIYLSIYTNIYLSMSSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DS88</accession>
    <name>A0A812DS88_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_59388</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004111">
        <property type="protein sequence ID" value="CAE1307283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DS88"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1307283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="254" mass="30475" checksum="5D2A277683AA7C43" modified="2021-09-29" version="1">MDGPGLAKRKLLGCPNIFSVYSDNFSSSFQIRVEERSIYLNMFVSIYLSIYLSIYLSIYLSIYLSKYIRIYLSIYLSIYLSIYVSYLSKYFRVFRLIYLSEYVRIYLSIYLSIYLNIFVSIYLSIYISIYLNMFVSIYLSIYLSIYLSIYIRIYLFIYLYIYLSQYVRIYLSIYLSIYLSIYLSIINLFRTVYPRQKRCPPTFYNCLRGNRHPPTSSLKLTYPFTQHTLCCPLCIPNNNVNLQHKRRGRLSLTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DSY9</accession>
    <name>A0A812DSY9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RTF1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SPHA_59824</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004146">
        <property type="protein sequence ID" value="CAE1307805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DSY9"/>
    <dbReference type="OrthoDB" id="166375at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990269">
        <property type="term" value="F:RNA polymerase II C-terminal domain phosphoserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.200">
        <property type="entry name" value="Plus-3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004343">
        <property type="entry name" value="Plus-3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036128">
        <property type="entry name" value="Plus3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13115">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN RTF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13115:SF8">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN RTF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03126">
        <property type="entry name" value="Plus-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00719">
        <property type="entry name" value="Plus3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159042">
        <property type="entry name" value="Plus3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51360">
        <property type="entry name" value="PLUS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Plus3" evidence="6">
        <location>
            <begin position="320"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="176"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="69"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="176"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="212"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="230"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="257"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="269"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAE1307805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="404" mass="46161" checksum="8D4FBD21153712C9" modified="2021-09-29" version="1">MSKRKIVIESDSDSDSDDNFDEQLKLLTKRKRADSDASTPAPAAPATEQNESSATSESDDEWTMDGKGSNKKKVKTPKKNNRKSVAISSESEEESERSASEPEEGEVSDSDHSSSEMSGSESDDKFFDGYDEDLIGDEEDRKRLEQMTEKEREQELYNRSERRAVLKTRFEIEKKLRQAKKKDQKEKKKASSDPVATRQVATPSQRSKERRKNIEDKKDSKMSAFKNLKARREEKKTKEIAIKEQQKKKMPVNSIYSDDDDDDDDEEGRESTERKTEKEDKSERKVSSSSSSSSSSDDRSSASSDSEEDSSSSRQKVTVYATKEDISRIRLSRNKMERWCHMPFFKNTVIGCFVRIGIGNHEGRPVYRVAEIIEVVETAKIYQLGSTKTNKGIRLRQVEKKTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DU16</accession>
    <name>A0A812DU16_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_59093</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004089">
        <property type="protein sequence ID" value="CAE1306981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DU16"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1306981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="180" mass="20706" checksum="9A5CD9B91E44FB1D" modified="2021-09-29" version="1">MTDKHKLKYKAKNFACFAEIFQSKCPGLSRYYMFKAQKITQDLSDELSNSWRSKYQNHIIGRYLRSKNKVAVTCLLFSESLSKIRLKKKKQKKTTTVKNVSLLSPDSPLLTSTPSMSNLSMSSNNSKWEPDATPLSSKYCRITPSSRKKNSKKFDHLKKLFANQKMEAEDSLIDFLQSVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DV10</accession>
    <name>A0A812DV10_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_60330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004191">
        <property type="protein sequence ID" value="CAE1308463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DV10"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1308463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="254" mass="30006" checksum="CFE630BAA1C48DC8" modified="2021-09-29" version="1">MSIYLSINILICSYLSILLFSYLSIYLSIYLSILDCSCLSFYIYFNLLFMSIFLSINILICSYLSILLFSYLSIYLSIYLSIYLSILDFYSYLSIYLSIYLSIYLSYLLFHSTHIYLSIYLSIYFSLFISIYLSIYLSIYRFILVSSYLSIYLSIYFSLFISYLSIYLSIYFSLFISIYLSIYLSIYFSLFISIYLSILVCSYLSIVCLSLFIFIYLSFILSIYLSIYFSLFISIYLSIYLSILVCSYLSICLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DV85</accession>
    <name>A0A812DV85_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_61449</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004347">
        <property type="protein sequence ID" value="CAE1309781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DV85"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1309781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="171" mass="19698" checksum="894FC1A2D62F57FA" modified="2021-09-29" version="1">MFFAITIYLNLNTIYLNIKLFIFLSIDLNLITIYLSKSNYTLSKFNHNPSKYYYNQAIYLNINTIYLNLITNFLSKSNLNLSKSNHNPSKSNYNHAIYLNLITIFLSKSNLNLSKSNHNPSKSNYNQAIYLNLITIFLSKSNLNLSKSNHNPSKSNHNLSICNSITPRKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DWZ6</accession>
    <name>A0A812DWZ6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_60640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004226">
        <property type="protein sequence ID" value="CAE1308827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DWZ6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="358"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="398"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="431"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1308827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="890" mass="95982" checksum="A7494030EEA6DA3B" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DXY0</accession>
    <name>A0A812DXY0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SLK</fullName>
            <ecNumber evidence="7">2.7.11.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SPHA_64517</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="7"/>
    <dbReference type="EMBL" id="CAHIKZ030004635">
        <property type="protein sequence ID" value="CAE1313376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DXY0"/>
    <dbReference type="OrthoDB" id="10027016at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022165">
        <property type="entry name" value="PKK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051585">
        <property type="entry name" value="STE20_Ser/Thr_Kinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46538">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46538:SF3">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12474">
        <property type="entry name" value="PKK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="29"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="289"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="138"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="205"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="289"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="306"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAE1313376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="338" mass="40765" checksum="A21CCBB9E8DE2AA6" modified="2021-09-29" version="1">MAAKKIKLEQDKELKIFKEQQKQDMKLLKQEHDLLPKGSKKEAFRKRKEEKEIEQSEKERQFLENQRERMEKHMKQLADQHRQKIALLESQYLQQKQQLLRAREAALWEMEKNQLHDKHQLAKGQLKDLFFLKRHQMLNRHQKEIDQMKRSNQAKEEEAQRYQLLDKKRHPKVIKNQSKVRAQMFKQSLRLSTVGSPEEDRLKMKQFEENEKKRMKSEAARLEAKHKKQWEKLLLDNETALRELEQLQAEKRKMLMEHETQKIKELDDQYQNELREWKSQLVPRKQKLEEEFFHQKEDQEKFYGSALSSGDGPTSHSTLSPGSLRKKDPSSARHSTII</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DZG6</accession>
    <name>A0A812DZG6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_63434</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004545">
        <property type="protein sequence ID" value="CAE1312170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DZG6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134:SF22">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134">
        <property type="entry name" value="OS08G0543275 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="322"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="360"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="410"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1312170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="430" mass="50174" checksum="8FA7633F89EFE344" modified="2021-09-29" version="1">MQSRLYFTCWSYVIPYLSIYLSIYLSIYLSIYLLMTIYLKPLDDLLSSYLSSLFYLSIYLSIYCMFTFTKISFSFLSYLPRFTNRSNLSIELCSYLSQFLRFSLSFSRSLILFISIYLSIYLSISVCFYLSIYLSQSAFIYLSIYLSQSAFIYLSIYLSQSAFIYLSIYLSIYLSIYLSLLLSIYLSISVYFYLSIYLSVYLCLLLSIYLSIYFSLLLSIYLSICLSMSAFIYLSIYLFQSAFIYLSIYLSISVCFYLSIYLSISVCFYLSIYLSIYLSIYLSLLLSIYLSIYLSLLLSIYLSIYLSQSAFIYLSLSIYLSIYLSISVCFYLSIYLSIYLSICSYLSIFLNKNMYLSGRIYLSIYLSIYLSIYLTLLLSMYVSISLSSIANRTGFDNCCSTDSVPSVSQMFYVTIVHISFFLSFFLSFNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E3L9</accession>
    <name>A0A812E3L9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_65027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="CAE1313990.1"/>
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</entry>
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</entry>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1317761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="220" mass="26546" checksum="5DB2A1A3ECE7F950" modified="2021-09-29" version="1">MYDSLLVLSTFFLSFLPSSLPSFIRFFSFFVILSFFLSFFIIYSFLSFFLPSFLSLFFIYLLFIPFFYFFLPSFLSFFLSSFLSFFLSFFSHPSFPPLFLSLFLPSYLTYCYYECFHYLKLLSLLIVREPYRVINFPSIYSSVIHSFLSFFISFFNSLLIFPFFFLSSFLSFLLYFFMFFFLSSFHSLLIYSFLLSFFLSFFLSFFLPSLFLLCMLSFSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EBP5</accession>
    <name>A0A812EBP5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_69396</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005072">
        <property type="protein sequence ID" value="CAE1318923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EBP5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="317"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="340"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1318923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="363" mass="43179" checksum="B31D3E3E240C2D1A" modified="2021-09-29" version="1">MFPTPSKYHILFLNASLVLSAYVNKNTRLSIYLSIYLSIYLLVSFYLSIYLSNSIQYLSIYLSIICQFLPIYLSIYLSICQFLSIYLSIYLFIYHLESIHYIAIYVTIYVTIYLSLISIYLSIYLSESIIYLSIYLSIYLSLCTYLSVSIQYLSIYLSIYLNLCTYLSESIQYLSIYLSIYLSICRYSVQRCSEERNVSHEYFSPENNKFYLSIYLSIYHLGSIHYIAIYVTIYLSLISIYLSIYLSIYLSIYLSLYYSFQLPPEKIGFFYCWLYLSIYLSIYLSIYLSQFLLLVISIYLSIYLSIYLSISIVIAGYIYLSIYLSIYLSIYLSIYLNFYYWLYLSIYLSIYLSIYLSIYLSIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EE89</accession>
    <name>A0A812EE89_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_71450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005233">
        <property type="protein sequence ID" value="CAE1321349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EE89"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1321349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="243" mass="30003" checksum="81C3AB4E60D9317A" modified="2021-09-29" version="1">MSNLEISFFSFYVKFGNFFLFLLCQIWKFLSFPFMSNFMSNLEISSNLKFLFFFVKFEISFFSFYVKFGNFFSFPFMSNLEISFFSFISNLEISFFSFYVKFEIWKFLSFPFSFQMSNLEISFFSFYVKFEISFFSFYVKFGNFFLFPFMSNLEISFFSFMSNLKFLSFPFMSNLKFLFFSFFPFFYVANWKFLSFPFMSNLEISFFLFKFEISFFSFYVKFFKKNCFKMSKISFFSFYFKFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EFL8</accession>
    <name>A0A812EFL8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_71665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005252">
        <property type="protein sequence ID" value="CAE1321599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EFL8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1321599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="352" mass="43562" checksum="B01F7B1FF0C91DE7" modified="2021-09-29" version="1">MVRSFSPLFLYYYVLIISLLLRSHYFFIITFLLFLYYYVLIRSFSLFISLLLRSYYFFIITFLYVFFSLFLFLYYYVLISLLLRFFIITFLYVPSSLFYFFIITFLLFLYYYVLIRSFSLLFLYYYVLVISLLLRSYTFLLSFISLLLRSHYFFIITFLLFLYYYVLIRSFSLLFLYYYVLIISLLLRSYTFLLSFISLLLRSYYFFIITFLYVPSLFYFFIITFSLFLLLLRSYYVLSLFYFFIITFSLFLYYYVLIRSFSLLFLYYYVLIRSFSLLFLYYYDLIISLLLRSFFHYFIFLSFLLSFTPAGLHPNLLLYLHFFLNSQYSILFPSSLSMFLPSFTYFTCKIVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EH90</accession>
    <name>A0A812EH90_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NOM1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SPHA_70857</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005188">
        <property type="protein sequence ID" value="CAE1320633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EH90"/>
    <dbReference type="OrthoDB" id="10260961at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050781">
        <property type="entry name" value="CWC22_splicing_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003891">
        <property type="entry name" value="Initiation_fac_eIF4g_MI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034:SF4">
        <property type="entry name" value="NUCLEOLAR MIF4G DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02847">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00544">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51366">
        <property type="entry name" value="MI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MI" evidence="5">
        <location>
            <begin position="612"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="48"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="150"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="53"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="85"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="166"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAE1320633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="801" mass="92225" checksum="4CCDAD130375D17E" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EHX9</accession>
    <name>A0A812EHX9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_75742</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005471">
        <property type="protein sequence ID" value="CAE1326177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EHX9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1326177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="254" mass="29519" checksum="C6F25DC51D122EED" modified="2021-09-29" version="1">MPSLISVLISVILHEYRADLTEYANTSAATVRIEQMDSYDKAINTCQVNQFQAEKPENDNDLEFVIQSRYLYVPISQCFFTLPISFYRLSPFLSRPIVSHSSYLPNHLITFSVFLYFSFFLYLCFLGGFFWGGETAHFCINITLIPIYLSIYLSIYLSIYWFKYIYLIVFASLSLSLSLSLSQSILQISTGRNGYSDIYLSIYLSIYLSIYLFFNIVRKWFYFLSRQLIASPIYLSLSLSLSLSLSTIYLSIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EHY2</accession>
    <name>A0A812EHY2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_72637</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005336">
        <property type="protein sequence ID" value="CAE1322729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EHY2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1322729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="161" mass="19140" checksum="A3BA354ADA74F3EC" modified="2021-09-29" version="1">MRSLFLRGTECNRINGLYFSSIYLSIYLSIYLSIYLCLQFSFFLFSICLILFTSIYLSIYLSIYLSIYLSHSLHICLLISMYPILFVSIYLSIYLSIYLSIYLSIYHFVNVAKLFLFIYFLSFFCLSFFLSFFLSQSVHIYLSIYLSIYLSIYLSISLFIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EIC5</accession>
    <name>A0A812EIC5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="14">SYT1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SPHA_74970</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Farmed</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Secretory vesicle</location>
            <location evidence="2">Synaptic vesicle membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the synaptotagmin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005445">
        <property type="protein sequence ID" value="CAE1325343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EIC5"/>
    <dbReference type="OrthoDB" id="67700at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031045">
        <property type="term" value="C:dense core granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048791">
        <property type="term" value="P:calcium ion-regulated exocytosis of neurotransmitter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048488">
        <property type="term" value="P:synaptic vesicle endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08385">
        <property type="entry name" value="C2A_Synaptotagmin-1-5-6-9-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08402">
        <property type="entry name" value="C2B_Synaptotagmin-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000007">
        <property type="entry name" value="Synaptotagmin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000016">
        <property type="entry name" value="Synaptotagmin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001565">
        <property type="entry name" value="Synaptotagmin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024">
        <property type="entry name" value="SYNAPTOTAGMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024:SF227">
        <property type="entry name" value="SYNAPTOTAGMIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00360">
        <property type="entry name" value="C2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00399">
        <property type="entry name" value="SYNAPTOTAGMN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="11" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="148"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="282"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAE1325343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="424" mass="47839" checksum="7A175565830FD602" modified="2021-09-29" version="1">MPAYLSDTLLRLKREAAMQEEADEITTAADEAAGSAMETVTKAAPKNGIDKIMDEALHELEKLPIWAIILICAGVLLFLVCGTYCCCKRICRRRKKKDGKKGLKGAVDLKSVQLLGNSIKEKVQPDLEELPMNMEDNEDAESTKSEVKLGKLQYSMDYDFQKGELTVNVIQAADLPGMDMSGTSDPYVKVYLMPDKKKKFETKVHRKTLNPVFNESFTFKNVPYADITGKTLVFAIYDFDRFSKHDQIGQVQVAMNSIDLGSVIEEWRDLTSPDNDAEKENKLGDICFSLRYVPTAGKLTVVILEAKNLKKMDVGGLSDPYVKISLMLNGKRIKKKKTTIKKCTLNPYYNESFTFEVPFEQIQKVSLYITVVDYDRIGTSEPIGRTFLGCNSTGTELRHWSDMLANPRRPIAQWHTLQEVPEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ELE6</accession>
    <name>A0A812ELE6_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SPHA_73409</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005377">
        <property type="protein sequence ID" value="CAE1323522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ELE6"/>
    <dbReference type="OrthoDB" id="5864054at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="7tmA_FMRFamide_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
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    </dbReference>
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        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srw"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053219">
        <property type="entry name" value="GPCR_Dmsr-1"/>
    </dbReference>
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        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46273:SF4">
        <property type="entry name" value="AT19640P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46273">
        <property type="entry name" value="MYOSUPPRESSIN RECEPTOR 1, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10324">
        <property type="entry name" value="7TM_GPCR_Srw"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
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            <end position="63"/>
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    </feature>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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    </feature>
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            <end position="244"/>
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    </feature>
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        <location>
            <begin position="55"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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            <dbReference type="PROSITE" id="PS50262"/>
        </source>
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        <source>
            <dbReference type="EMBL" id="CAE1323522.1"/>
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    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="375" mass="43102" checksum="ABD0B54401EDDCBB" modified="2021-09-29" version="1">MTSTPPPLPTPVLSMTLAPPQPDMSAYNSLTLFGRWYAHIHGYLSTCVCVFGIVTNIFNITVLSRKNMSTPVNNILTWLAVSDMITMLSYVPFAMHFYVLNNPTYITPEKNDWPWTVFMFFHFNLVNTTHTISIWLCVLLSILRYAHLRSPARGELIRVRRLKFSRAFIACVYIGSAIMMTPNFITKEIIEKNTSTSSVYIIRDTNIGNSDFWTTVLVQYWLYAITGKLLPCVLMFIFGSLLIYKIREKTRKRKHMMQISCTNRTRLSEHSRTTKMLLTVIVLFLATELPQGILIVLSITTPNIFDHIYVPLGDLMDILALVNNAINFVLYCSMSQKFRHTFIEVYCSCLCLRPEKEAGIPLRQKLDSYSNNNQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ER95</accession>
    <name>A0A812ER95_ACAPH</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">SPHA_80618</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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            <taxon>Metazoa</taxon>
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            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005604">
        <property type="protein sequence ID" value="CAE1331409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
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            <begin position="26"/>
            <end position="6677"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
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            <position position="1"/>
        </location>
    </feature>
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            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAE1331409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="6677" mass="730557" checksum="13771F7C9A236DBE" modified="2021-09-29" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EWY6</accession>
    <name>A0A812EWY6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_80210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
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                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005594">
        <property type="protein sequence ID" value="CAE1330957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EWY6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
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        <source>
            <dbReference type="EMBL" id="CAE1330957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="194" mass="23560" checksum="3E501E109096862D" modified="2021-09-29" version="1">MYHIYILSIYLSIYLSHSDHIYLSHSDLSIYLSIYLSYSDHFSLFIYQSVHIYLSIYLSIYLFISSYISQSVYVYLYLSLFLSLTFFLAFFFFLSHFSFTFYSFFFCLFSSSVEIRFSLTHFFFIHILLLRSPPFSFVNVLFLGIPFLSFAFSFTFYSFFFYSFSSSFDIHLSFTYPFFFVRILYLLFYSFSFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812F0S9</accession>
    <name>A0A812F0S9_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SPHA_81316</name>
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    <organism evidence="7 8">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
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            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
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            <taxon>Sepiina</taxon>
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            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Farmed</strain>
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    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
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    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005630">
        <property type="protein sequence ID" value="CAE1332251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
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        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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            <begin position="20"/>
            <end position="43"/>
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            <end position="1125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAE1332251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1156" mass="134475" checksum="970C2A8745962153" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AKF1</accession>
    <name>A0A812AKF1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_539</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000011">
        <property type="protein sequence ID" value="CAE1140332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AKF1"/>
    <dbReference type="OrthoDB" id="6819399at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134:SF22">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134">
        <property type="entry name" value="OS08G0543275 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1140332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="208" mass="23775" checksum="88573802C5F6C598" modified="2021-09-29" version="1">MPGYSTPESVHIYLSSYLSIYLSLFIDISVCSYLSIYLGLFISIYLGLFISIYLSILVCSYLSIYLSWSVHIYLSISVCSYLSIYLSISVCSYLSIYLSIYLSLFISIYLSIYLSLFISIYLSISVCSYLSISVCSYLSIYLSQSVHIYLSIYLSLFISIYLSISVCSYLSIYLSIYLCLFIIYLPLSLHYLSTSVSSLFIYISLFNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AML7</accession>
    <name>A0A812AML7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_1068</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000029">
        <property type="protein sequence ID" value="CAE1142636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AML7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
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            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1142636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="303" mass="34999" checksum="3BC70C7A00F7DDA3" modified="2021-09-29" version="1">MRLLKLGIVVPLCLIAILLSCSSVLFSPAVSLLQLSFFSSLSLKNSLPFFLFPTPPNSVSRSQVLTSRLFISIYLSIYLSIYLSSFILVTGFSIPCPYISYLSFSLSLSLSLSIYRSIYLSIYLSIYLSIYLSIYLSLFISIYLSIYLFIYLSHSLHIYLYKFISILLNLYIRHVDIYLSIYLSIYLSIYLSISIAIICSEENKIYLSIYLSIYLSVCLSVCLIMFISNTHSFFVSYSHSIYLSILILSIYSRSIYLSIYFYLSIYLSIYLSHFQTSSFLFIPLYNISNLFYLSIYLSIYLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ATL9</accession>
    <name>A0A812ATL9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_4221</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000131">
        <property type="protein sequence ID" value="CAE1154453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ATL9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="335"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="370"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="396"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="425"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="454"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="488"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="540"/>
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        </location>
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        </location>
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        </location>
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            <end position="715"/>
        </location>
    </feature>
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            <begin position="727"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="754"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="794"/>
            <end position="818"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1154453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="820" mass="98358" checksum="CB8073B8B47CD7AF" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AU70</accession>
    <name>A0A812AU70_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_5570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000183">
        <property type="protein sequence ID" value="CAE1158319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AU70"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
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        </location>
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            <end position="239"/>
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            <end position="310"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAE1158319.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AUU1</accession>
    <name>A0A812AUU1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_5048</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000168">
        <property type="protein sequence ID" value="CAE1157098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AUU1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1157098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="161" mass="19186" checksum="C2639D7F60F7302C" modified="2021-09-29" version="1">MDVKSGETFLLLSCRITNKHDKLLHEANDYLLIPSPEDLSRFVCLFFLSIYLSIYLSIYLSIPDCSYLSIYLFQHVHIYLSIYLSIYLSIYLSIYLCGVTLDPIYLSQFFHYLSINFILFTIYLSIYLSIYLSIYLSIYAILFICIYLSIYIFFHYLIFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AYJ0</accession>
    <name>A0A812AYJ0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_7602</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000243">
        <property type="protein sequence ID" value="CAE1163192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AYJ0"/>
    <dbReference type="OrthoDB" id="10619954at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1163192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="151" mass="17353" checksum="581010776D26AF4B" modified="2021-09-29" version="1">MEIDFNIFSINLFSMILRNSFSSIKYIQSSCFFFHTVLKTIYLSIYLYIYLSIYLSIFSIKYTPSLKLHLYMGIRIPVCIENITFLSVCHIFTHTLYTSGGPKSNGNRFLCDKPVVVQASTARCHLRRPPGISVLTGVIVGRRTAPWFTFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AZ27</accession>
    <name>A0A812AZ27_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_7405</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000237">
        <property type="protein sequence ID" value="CAE1162668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AZ27"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1162668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="213" mass="24919" checksum="C0775FE41D7383B0" modified="2021-09-29" version="1">MDIIACFSLRRCLSIYLSIYLSIYLSIYLSISVFSYLSIYLSIYIFTFFLSICLSICSFFIYLNVFIFVLSQSVHFLYYSLHEENLSIYLSIYLSIYLSIYLSHSVGFCIYLSIYLYIYIYIYIYIYIYIYIYISICFSLYLFPAIHFLFYILFMGNLSIYLSIYLSIYLSIYLSILFRELLSIYLSISISFISSSSSSSSPSSPSSSSSSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AZ45</accession>
    <name>A0A812AZ45_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_7868</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000255">
        <property type="protein sequence ID" value="CAE1164044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AZ45"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1164044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="257" mass="28417" checksum="296827723CBAEE1F" modified="2021-09-29" version="1">MSLFCLHSLDKRFFSLLRLTSFLLFIITSFLRFCDLSHSSLNSLHKLPFPYFLPSFIDSLPLSPSYFPFSLFLFIFFISLTLFYAFTQTILVLLYSQVSFLSFVPFYFYTSLSSFFFPSLFISPLFPVDFIRLSLCYARKKMSLSWDNTEIDVDIVSSAAAVAAAAAPLMTILTPSTVASISPAATLMTSMTTPAADSIAIAETLIISLTPSVAAFIYATASLMKIMTLSIAAAIVTSISPAEASLPNLALFTYDLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B1S4</accession>
    <name>A0A812B1S4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_9449</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000302">
        <property type="protein sequence ID" value="CAE1167543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B1S4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1167543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="374" mass="43395" checksum="4D4A961DA96CB864" modified="2021-09-29" version="1">MMSFLLSSLSFSCTICHPFPYPSYPSLLSSAILFPYPSSSLVPSFSHILLLWHPFPISFSYGILFPYPSLMPSFSHILLLWHPFPISFSYGILFPYPSLMASFSHILLLWHPFPITYSYAILFFPYPSLMPSFFSHILLLCHPFFPISFSYAILFFPYPSLMPSFFLISFSYAILFSHILSYAIPFFFSYPFLCHLFFPYILLLWHPFFPISFSYAILFFPYPSLMPSFFSHILPPFFPLVLSPLLFLFHSNAVLSLYTLSSLVLSFPLSLLPLLFCYSHSHAVLPCYANYSLLFLPPPASSHTTTPAFIMLLLLRFLLFFLHFVSCHLKIVIILEYYFSYTFILQFFFSSVYTTFPFQMFSTLQFALSTFSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B675</accession>
    <name>A0A812B675_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_10593</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000343">
        <property type="protein sequence ID" value="CAE1169415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B675"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1169415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="169" mass="19535" checksum="5662CB88D88B35BC" modified="2021-09-29" version="1">MYNTICLSIYLSIYLSIYLSMSMSIYLSIYLSIYLSISLFMSIQVCSCLSTYLTQSVHIYLSIYLRLFIPVCSYLSIYLSIYLSIYLSIYLSQSVHACLFISIYLSIYLSIYLSISVCSCLSVHIYLSIYLSIYLSIYLSIYLSLCLPFLLSLCISINIYLSERISHQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B859</accession>
    <name>A0A812B859_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_11983</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000401">
        <property type="protein sequence ID" value="CAE1172240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B859"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1172240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="210" mass="24579" checksum="F9C29FCB118DB9F9" modified="2021-09-29" version="1">MSVSSFSLSLSLSMSVSSFSHYLSIYLSIYLSIYLSIYQDMCIIYLSIYLSIYLSIYLSIYLSDYKYKCVIRTSIYLSIYLSIYLSIYLSIYRLLIFLFFSFFLSFLLSFYLSIYLSIYLSIYLSIYLSQSVHLSLSYSLSNLFSISFSLLGYYDWIFKASHIHIIQSIWFLLLSLSLSLSLSIYLSIYLSIYLSIYLSIYSLILSGIRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BDZ6</accession>
    <name>A0A812BDZ6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_14933</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000514">
        <property type="protein sequence ID" value="CAE1177944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BDZ6"/>
    <dbReference type="OrthoDB" id="6819399at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1177944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="250" mass="29578" checksum="3FC7F901AE4C6698" modified="2021-09-29" version="1">MKKTKKHQTNFPRKYTSSAQAAARDDRMISSLAAAWAEQSPHIYISIFLSIITMISMYLSLLIYICIFLTHYILIYISMYISGLSIYLSIYLIEFLHYVSIYNSLFISIWINLYAHICLSIVVCSYLSIYCSMFITIHLSIYLSIYLSIYHNMLISIYLTIYCICSYLSIYLSIYLLQYAHNYLSTYLLHYAHIFQFIYLLQYAHIYLSIYLSIYLLHILIYLSIYLSIYLSIYLSISSNNPQRNIMMND</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BGE8</accession>
    <name>A0A812BGE8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_16968</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000602">
        <property type="protein sequence ID" value="CAE1228892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BGE8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1228892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="284" mass="32770" checksum="2BFAA9DAD5E44E3A" modified="2021-09-29" version="1">MKKKTILCICLSSASLTFYKLSSYRARYLHSLSPSPLSLSLSLSLSLYIAVSVIFVTSQLIIFRSTFMMASFCFYLHHQQHHQRCLSLTKTFNSFSDSFGSDIIISPITRKPFPSSSLASSPLLPLLLLPILLLPILLLPSSSLPLFFYFFYKVFIVYSLISSRPLLHSSSSSSSSSSNLSSSFFFFFFFFFFFFFPFSSSIKYYLLFIISSSPLHFSSHFFKVLFSVYILIRSSSSSFFFFFFFFLTQYFFSSVVRQEQQISFCRLFIFFCIGTRLTSILTIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BHV6</accession>
    <name>A0A812BHV6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_15877</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000556">
        <property type="protein sequence ID" value="CAE1226166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BHV6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1226166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="177" mass="20514" checksum="4F9AA1EFD4D56A0B" modified="2021-09-29" version="1">MKDNEKSSQISLVLTFLLSAFCSLSLSLSLSLSLTVFFLLHYLLYLSIYLSIYLSIYLLQPVHYLSIYLSIYLSIYLSPWALRPCIVIHEMETLIQKSLSLSLSLSLSLSLSLSLSLSDRHTRIRAAIHYTFMYKLNRHYSSLVSLLTCYLFRKNDHCKATILTDKCLRNAQRSRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BKN0</accession>
    <name>A0A812BKN0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_19432</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000705">
        <property type="protein sequence ID" value="CAE1234527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BKN0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAE1234527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="705" mass="84117" checksum="ECBAB1B0CE4A3513" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BMG5</accession>
    <name>A0A812BMG5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_20368</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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            <taxon>Decapodiformes</taxon>
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            <taxon>Sepiidae</taxon>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">Farmed</strain>
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    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BMG5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAE1236696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="214" mass="24942" checksum="D7C7015EEACBD257" modified="2021-09-29" version="1">MYLCIYLSIVLNFLSIVLNFLSIYLCIYLNYLSKLSIYLSIYLSIVLNFLSIVLNFLSIYLSIYLSIYRSKLSIYRSNLSIYLSIYLSIVLNFLSIVLNFLSIYLSIYLCVFVPVCLCTFDPFIEESQGRVRGEHPSIYQAALMISFFHRKEKNTCIGTKMQFIHGLFNAFCYLNCEFLQETRYFILASIYLSIYLSIYLSIYLSISGDSGIYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BN25</accession>
    <name>A0A812BN25_ACAPH</name>
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        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="9" type="ORF">SPHA_21907</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
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        <lineage>
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            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
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            <authorList>
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                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000806">
        <property type="protein sequence ID" value="CAE1239643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Cyt_c_oxidase-like_su3"/>
    </dbReference>
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        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
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        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        </location>
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        <location>
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        <location>
            <begin position="162"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome oxidase subunit I profile" evidence="8">
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            <end position="1181"/>
        </location>
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            <begin position="1218"/>
            <end position="1406"/>
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    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAE1239643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1406" mass="177108" checksum="1C2C4E301F0B80F9" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BNN9</accession>
    <name>A0A812BNN9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">GALK2</fullName>
            <ecNumber evidence="9">2.7.1.157</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SPHA_20004</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Farmed</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GHMP kinase family. GalK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.157" evidence="9"/>
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        <property type="protein sequence ID" value="CAE1235977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BNN9"/>
    <dbReference type="OrthoDB" id="187738at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004335">
        <property type="term" value="F:galactokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033858">
        <property type="term" value="F:N-acetylgalactosamine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1440.340:FF:000001">
        <property type="entry name" value="N-acetylgalactosamine kinase isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000705">
        <property type="entry name" value="Galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019741">
        <property type="entry name" value="Galactokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019539">
        <property type="entry name" value="GalKase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006206">
        <property type="entry name" value="Mevalonate/galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00131">
        <property type="entry name" value="gal_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457:SF7">
        <property type="entry name" value="GALACTOKINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457">
        <property type="entry name" value="MEVALONATE KINASE/GALACTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10509">
        <property type="entry name" value="GalKase_gal_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000530">
        <property type="entry name" value="Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00473">
        <property type="entry name" value="GALCTOKINASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00959">
        <property type="entry name" value="MEVGALKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00106">
        <property type="entry name" value="GALACTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Galactokinase N-terminal" evidence="8">
        <location>
            <begin position="30"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="6">
        <location>
            <begin position="129"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase C-terminal" evidence="7">
        <location>
            <begin position="363"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAE1235977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="461" mass="50745" checksum="E0862601AD5BAF5B" modified="2021-09-29" version="1">MPDDSDYPPVKDLSKLDDKQKLRYQDLSNNFKEKYGKLPQFFASVPGRVNLIGEHIDYCGYSVLPMAVEQTIIIAAHVTKDDKISLSNKNPEFEDYECSVGHVIDKSFAAWYTYFLCGLQGIKDSGKAKKLHGLQCMVDGNIPKSAGLSSSSALVCCSALVIAHANGIKFTKTRLAEICAVCEHYCGTEGGGMDQSIAFMAEPGQAKLISFNPLTATPVQLPPGVVFVVSNSCVMMHKAATCHFNVRVVESRIGAQIIAKKKNLDWRSLRKLSEIQEALKYDLKEMLSCAKELLHPDPYTKEEICSLLEVSPQELANTSLSENTLHVEKFKLYDRVTHVFAEADRVFQFKEVCGMTSDDACQKLGGLMNESHSSCSKLYECSCEELDKLVEICLESGALGSRLTGAGWGGCAVSLVPEEILKSFLDKVKSEYYLSNPELANKVEDSLFASRPGCGAFICKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BSE6</accession>
    <name>A0A812BSE6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_21926</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000807">
        <property type="protein sequence ID" value="CAE1239690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BSE6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1239690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="277" mass="32690" checksum="D7550040B44CB64A" modified="2021-09-29" version="1">MNINDAQLFLAPKLNHAALRQSKQSNNRLSKTIHYLCFSFIHSFTLSFFLSFSFIHSFFLSFFHSFILSLIHSFFHSFILSLILSFIHSVFPCFFSLARLLDLICFVRFHTNGLVAPKLSHAAVCQSNKSNNRVPKTIQYLCFSFFLSFFLSFFLSFFLSFFELCLSPRTFSKRLDFFFPYFSLISFFLSFISFPITCNIFFISFFLSFFLSLFIYLFIYLFIYLSLLFYIAFFAFNISSISFFPFLPFPITSNISFFLSFFLSFFLSLFATLSLQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BT84</accession>
    <name>A0A812BT84_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SPHA_23606</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000873">
        <property type="protein sequence ID" value="CAE1243066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BT84"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="251"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="285"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="418"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAE1243066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="474" mass="52288" checksum="4FE94557B58C0855" modified="2021-09-29" version="1">MGLRYERIYIITPLPSTCYIITSPFLYLSSFLVLSPFVSFAVTLPLFSFPSFFLSFILLVALLFYRFLFVVCLSIYLSIYLSIYLSISLRRLQNIADIETRTTDLDFTFAFTSSSSSSSSSSSSSRFFYFSSSFFFLSSLLLLLLFFFFFFIFFFFFFFFFFSFFLLLLLLLLPLLPIVAVVVVVVVVLLLLLLLLLLLLVFSTSPSPSSSSPPHCCCCCCCCSSSSSSSSSSSSSSFFLLLLLLLLPPPLLLLLLLLLFFFFFFFFFSFFLLLLLLLLPLLPMVAVVAVVVVVLLLLLLLLLLLLVFSTSPPPSSSSPPYCCCCCCCSSSSSSSSSSSLHCLSVCLSVCLSVSLSLSLSLSLSLSSPSTSSATRDGPESVKGKVVISARPPAKHPLPGLALIVDTNASSIRPQSRHYLLLLLLLGITFLHLTLDRQLFQLLTDAFQARMCSVDLLSAQCVAAISFPHTGHIRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BTF5</accession>
    <name>A0A812BTF5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">KRAB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SPHA_26543</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001014">
        <property type="protein sequence ID" value="CAE1249326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BTF5"/>
    <dbReference type="OrthoDB" id="427030at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399:SF23">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399">
        <property type="entry name" value="ZINC FINGER AND BTB DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="34"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="127"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="155"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="183"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAE1249326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="318" mass="36424" checksum="BAA2C1FE9748AD10" modified="2021-09-29" version="1">MQCTFTFNLLTPFLKSVFKSHCDEHLKTHTGEKLECSQCKRLFASFHLLRMHLRSHAEESVAGDDFEANDYESNAAMVLDSFLVPTTEEKPKESDVLEKPPESVEGKYDLPSTDLNAAPNVSVIRHLQCTYCHKLFSRSSNLTKHLNIHTKERSFKCNHCDKTFLHSFALTRHLRVHTGEKPYKCAHCSRYFSDPSTRNRHAKLHTQKQKSLTFGYKDGNRDITNNSNAGFDIQLNGNYSKKNNIDDFNCGSVQRASQLYSSLDKKMAGREELTRNNNSTDEDDDDMQPVLEILSANQEQSFIINSENTKQFDVINDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BTJ2</accession>
    <name>A0A812BTJ2_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SPHA_23750</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000879">
        <property type="protein sequence ID" value="CAE1243298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BTJ2"/>
    <dbReference type="OrthoDB" id="504170at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000097">
        <property type="entry name" value="Bent, isoform F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050958">
        <property type="entry name" value="Cell_Adh-Cytoskel_Orgn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080">
        <property type="entry name" value="CONTACTIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080:SF8">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="9"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="116"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="307"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAE1243298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="354" mass="38172" checksum="F8736CF17CF87370" modified="2021-09-29" version="1">MGVGDEVAPRFTTKPSLKQEDGGKRLVFLCALEASPQPEITWFLGNTELKASDKHKMKVEAKGGIAYNIVMELIGVAKDDAGTYKVVAKNKLGEVSANINLNLGGAAKKQADGVAPNFTTKPSTRQVGKNLVMECQLTAEPKPSLEWFRDDAPIKSGGRITIIAESKGPQTYLLKLEIKDVANGDAGNYKVIAKNELGESNATIKLNFDSSAADAAKGKPMFTGKPAIRQLGDKLIIEFSSARSVWNFDSFGLLRTLHSNEIRPSIAGVTSRCFTVTVCTSPFDRNTCNSAQRLHLLRRGLAPSGAVVSNQSRNAETEGSFIGRHDSRRKKENTLPAKGLLTLTLLRGALKSQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BTT1</accession>
    <name>A0A812BTT1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_22060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000813">
        <property type="protein sequence ID" value="CAE1239878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BTT1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="321"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="359"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="414"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="445"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1239878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="468" mass="54679" checksum="073725CBA6DDA1E3" modified="2021-09-29" version="1">MSRVGLQRKSKRSSMLVYKSCTDPVCNRFLRLSYINPVPIEDEVCVSCRRVYCEIPSVLRCSFYGEYPSVLRLSYINPVPIEDEICVSCRRVYCETPSVLCLSYINPVPIADETCVSCSSVYCETPSVLRCSCINPVPIPFVNLCLVSFYGEFPSVLRLSYINPVPIEDEICVSCRIVYCETPSVLRCSSLNPVPIPYVNLSLMSYVLLRSSKRSSVLIYKSCTDPRCLRSYVIPSFYLAFLPSFLLSFLHSFLPSFFHSFFPSFLPCFLPSFCPSFFLFSFLPPFLPFFLLFPFFFLSFLPSFIPSFLSSHRRSSLPSFIPPFFHSFIHSFLSFLPSLLTYLLTHVLPTFFHSFVRSFLSFLPSFDFSFFFISPVIPYFFNLAFKHLFSNLLFFVRSFVFSFFPSFFFLSFVWFFFLSFFLLSFFLFSFCSLYFSFFLSFFHSFFVSFLLSFSFVLCFFFLFPFFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BU85</accession>
    <name>A0A812BU85_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_25450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000964">
        <property type="protein sequence ID" value="CAE1247067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BU85"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1247067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="345" mass="41169" checksum="BF1EF1740352215D" modified="2021-09-29" version="1">MILSIYFLSLILFCPFLSLSLSASFLFFKYFRLISFFKYFRLFSFLSLSASFFLYDSFHLFSFFNSFCLFYFFNYFGLFFFFKPIHVHYFFKSFCLFSFLFPSLFFLCVYFLSLSLSTYFLSLSLSASFLSSFRLFSLFKSFYLFSFFSLSISFLSLSISNYFLSLSLSASFLSSSIYVSFLSLSLSIYFLSVCFFIYFLSLSLSPSFLSLIFLPRFFLKSFRLFFSFKSFRLFSFFKSFHLFSFCKSVCLVSFFKSFRLFSFFKTFCLVSFYKSFHLFFSLSISPSFLSSSIYVSFLSLSRSASFLYLSFFHLFSFFESFHISSFFKSFHLFSFFKVFLPLLFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BUB1</accession>
    <name>A0A812BUB1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_23077</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000856">
        <property type="protein sequence ID" value="CAE1241948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BUB1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032451558" evidence="2">
        <location>
            <begin position="19"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1241948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="151" mass="16391" checksum="72DCC2AE5929834D" modified="2021-09-29" version="1">MCLSLSLSLSLSLSVCLSVYLSACMSICLSFSLCVVYMSVCLSLPLSVSLSVCLSFSLLSISLCLSLFLSVCLALCCLSLSLSVSLAVFLSFCLSVSLSLCLSVCLSFCLEFLIHSTLHVEFFTYPHIIPELSSFNSYFLPVGFVDFVFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BUI3</accession>
    <name>A0A812BUI3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_27233</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001047">
        <property type="protein sequence ID" value="CAE1250656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BUI3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="286"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="315"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="349"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="373"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="407"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="444"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="485"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="521"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="563"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="590"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="620"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="657"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="689"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="721"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="753"/>
            <end position="774"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1250656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="775" mass="90397" checksum="A952F19E765F2AEA" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BYW8</accession>
    <name>A0A812BYW8_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA repair endonuclease XPF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SPHA_24703</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000926">
        <property type="protein sequence ID" value="CAE1245383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BYW8"/>
    <dbReference type="OrthoDB" id="361020at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000110">
        <property type="term" value="C:nucleotide-excision repair factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901255">
        <property type="term" value="P:nucleotide-excision repair involved in interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20078">
        <property type="entry name" value="XPF_nuclease_XPF_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10130:FF:000002">
        <property type="entry name" value="DNA repair endonuclease XPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006166">
        <property type="entry name" value="ERCC4_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047520">
        <property type="entry name" value="XPF_nuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10150">
        <property type="entry name" value="DNA REPAIR ENDONUCLEASE XPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10150:SF0">
        <property type="entry name" value="DNA REPAIR ENDONUCLEASE XPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02732">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00891">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC4" evidence="12">
        <location>
            <begin position="627"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="442"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="593"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="455"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00072370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAE1245383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="872" mass="99778" checksum="ECD9404512FA411D" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BZ32</accession>
    <name>A0A812BZ32_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">SLC2A13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SPHA_29474</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001173">
        <property type="protein sequence ID" value="CAE1255330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BZ32"/>
    <dbReference type="OrthoDB" id="4142200at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005366">
        <property type="term" value="F:myo-inositol:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF12">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="54"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAE1255330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="157" mass="17050" checksum="65F5EE6F7EFEB5CE" modified="2021-09-29" version="1">MEMTKMGSSMGEGNRQRPDKLYENSDEYEEKTLYGLKLDTLTSKLRTPQFIYILTFFSALGGFLFGYDTGVISGAMILLRNTFLLSSVWQELVVSVTIAGAAVFAIVGGLLNDRIGRRPTIMIASVVFTVGAFCMGMAPDKYVLLGGRIIVGAGIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BZM5</accession>
    <name>A0A812BZM5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_25718</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000974">
        <property type="protein sequence ID" value="CAE1247502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BZM5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1247502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="234" mass="26911" checksum="7960D85508F957C7" modified="2021-09-29" version="1">MTSESPAYLSIYLLFYLLFYLSIYCSIYCSIYLSIYLSIYLSIVLSIVLSIYLSIGSIWIIYQRICYLYIIYLSIYLSIYLSVYLSIYMSFDLSALSLFLSLSLLAFDSLSLSISVPLSPLSSSLSLSLSIYLSIYLFTYLHFLRLRFHLGHYHSFVSLFFCDIFSLSPSLSRSISFFHSLPFLLHYLSLSSTLSLSLLISLYLSPFFSSPFFIKIILSLSLSLSIYLSIYLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C0D5</accession>
    <name>A0A812C0D5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_27434</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001065">
        <property type="protein sequence ID" value="CAE1251208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C0D5"/>
    <dbReference type="OrthoDB" id="8960483at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1251208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="217" mass="25527" checksum="73E11E7661886208" modified="2021-09-29" version="1">MPNAVLFILSLFSLPVRNSSNLYIYPYFSASSALIYPSQLLPISRSNYISICLSQPLFYPSICLIIFINIYLSKYLSIYLSIYLISLSQYVHIYLSIYLMFISIYLSIYLMFISIYLSILCSYLCLYLSHLSLFPYLSIYLSISISNMLIYIFISMYVHIYLNMFISIYRSQSVHIYLSIYLSLFISIYLSIYLSLFISIYLSIYLSLFICICHLYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C0G8</accession>
    <name>A0A812C0G8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_24963</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000942">
        <property type="protein sequence ID" value="CAE1246015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C0G8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1246015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="230" mass="27031" checksum="5A93B61510049919" modified="2021-09-29" version="1">MKSYTITDRKSTNILGMLSILLFLSLSHCFPQLLNFSSILLYHVLSFPFSSSVCPFSLSYPCSLPSNLYPLSLSLSLSLSLSFPWLLSFSSTLFSTVFFPFIFSTFSQFFHTLPSLYISFKLFPILSLRHILFISFFSFFFVSLNLCWHSISFTSHSLPFFFSFHFLCIIIHHFHFWLIFIFFLIINSSFLPPPFSLCSFLFIAIFLHHFSFFSLFSSYFPVFFFYLYSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C0V7</accession>
    <name>A0A812C0V7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_27752</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001087">
        <property type="protein sequence ID" value="CAE1251951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C0V7"/>
    <dbReference type="OrthoDB" id="10070995at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="297"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="335"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
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    <sequence length="464" mass="55007" checksum="18250A3BAAEFD4B4" modified="2021-09-29" version="1">MLKSLFNYGDYSFDGQILSAAFSTLIHLSVIFQHSSIYHSSIYLSIHLHPFIYLSIYLSSTICSLFSIHSSIYLSIHPSIHPSIQPSIHLPSPSIHLFLLSHHPSIHHNLFISIHIHPSFDHQSVSIHYPSFIYPSIYHSSIIHHHLSICSLSIHLSIYLSIICFIIHLSHLSIYLSIIHHSSIHRHHPYLIYPSIHLSIHPSIIHLSIIIYLYPFIIYLSKIHIYIYIYHRFSSIYLSIYLHPFIYLSLHLSSIHPSIIIHLSICHNIFIIYQLTSRIIQYLSIHLSIYPSIYHNLFLSIYLSASIYLSSMFIIPHFSSISLPFDYFFSPSLFFYIFFLFIYLYYFIITTSLHFFSFFSLYLKTRFYASVLFPFFFCFRLYSFLIFFSLSFSFLNNYVFFINFLFKFSSLFLILVRFSFFYLSVISFFFVFSFFDLSISLIRTAFQFISIVSDNHKLIYLLMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C1P7</accession>
    <name>A0A812C1P7_ACAPH</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">SPHA_29712</name>
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    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C1P7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
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        <source>
            <dbReference type="EMBL" id="CAE1255597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="855" mass="99494" checksum="9103CDC037342B14" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C3A7</accession>
    <name>A0A812C3A7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
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            <taxon>Sepiina</taxon>
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                <person name="Bekaert M."/>
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            <strain evidence="2">Farmed</strain>
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    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000597762">
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        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <organism evidence="3 4">
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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            <taxon>Coleoidea</taxon>
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                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
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    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1256806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="236" mass="27266" checksum="0406140E1D3F4D7B" modified="2021-09-29" version="1">MTLFLISLLLLLFFYHLIPRFSSSSSSFLLSPYPHFSSSSFLFFITLSLISLLLLLLLLSPYPSPSFFFFIFYDLIPHFSSSSSFSSITLSLVSLLLLLLFLLSPYPSFLFFFFFFFFYHLIPHFSSSSFSFSSITLSLISLLLLLLLLLSPYPSPSFFFFIFYDLIPHFSSSSSFLLSPYPRFSSSSSSFLLSPYPSFLFFFFFFFFYHLIPHFSSSSFSSSITLSLTFLLLLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C6G2</accession>
    <name>A0A812C6G2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_32068</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001334">
        <property type="protein sequence ID" value="CAE1260203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C6G2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34723:SF7">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34723">
        <property type="entry name" value="PROTEIN CBG17025"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="539"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="568"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1260203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="623" mass="69594" checksum="8591964CB1B13F05" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C6Q5</accession>
    <name>A0A812C6Q5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_29397</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001169">
        <property type="protein sequence ID" value="CAE1255194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C6Q5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1255194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="306" mass="37007" checksum="A6A89633A044D2D0" modified="2021-09-29" version="1">MFDIPLSSALLFCNTHFLKCSPKNLLNFFFFPSSFLCCLSFISFHFHFFHFISFFLFTFFSFPILILFYFPFLSFLYPFFHSFFFLLTSFLSFSPSFYSFFYLFSFLFLYFLFSFLLLSFLYLFFFSFCCSFILSFFLSSVFFSFLPFFFYFFSFAFLSLLYFITSFFPSFFPSFLPSFLLLFFVSLFLSFFFLSFFLSFFLYLFIYLRFSVCLSVFLLFFLRTFRSFFFFPISIHLCYIKKKKKERKENHERHQSLTSVFESHNNAVSSGIDKQLHSSSLLSVTFHHRLPTIFKNLGQQSLTSHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C9L5</accession>
    <name>A0A812C9L5_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">TIR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_30883</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001247">
        <property type="protein sequence ID" value="CAE1257677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C9L5"/>
    <dbReference type="OrthoDB" id="10037120at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="186"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="222"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="600"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="661"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="604"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="689"/>
            <end position="715"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1257677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="784" mass="89460" checksum="66FC7494EE479787" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CCJ5</accession>
    <name>A0A812CCJ5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Echinoderm microtubule-associated protein-like 6,Echinoderm microtubule-associated protein-like 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SPHA_30975</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001254">
        <property type="protein sequence ID" value="CAE1257900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CCJ5"/>
    <dbReference type="OrthoDB" id="47802at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000040">
        <property type="entry name" value="echinoderm microtubule-associated protein-like 6 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000044">
        <property type="entry name" value="echinoderm microtubule-associated protein-like 6 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055442">
        <property type="entry name" value="Beta-prop_EML-like_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055439">
        <property type="entry name" value="Beta-prop_EML_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005108">
        <property type="entry name" value="HELP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050630">
        <property type="entry name" value="WD_repeat_EMAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13720:SF33">
        <property type="entry name" value="HELP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13720">
        <property type="entry name" value="WD-40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23409">
        <property type="entry name" value="Beta-prop_EML"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23414">
        <property type="entry name" value="Beta-prop_EML_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03451">
        <property type="entry name" value="HELP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="EML-like first beta-propeller" evidence="5">
        <location>
            <begin position="58"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="238"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="EML-like second beta-propeller" evidence="6">
        <location>
            <begin position="333"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="564"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAE1257900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="786" mass="87981" checksum="042D19A78949055D" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CCX3</accession>
    <name>A0A812CCX3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_35396</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001522">
        <property type="protein sequence ID" value="CAE1266925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CCX3"/>
    <dbReference type="OrthoDB" id="6436329at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052997">
        <property type="entry name" value="RRT15-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33047">
        <property type="entry name" value="PROTEIN TAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33047:SF8">
        <property type="entry name" value="REGULATOR OF RDNA TRANSCRIPTION PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="474"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="676"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="825"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1021"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1111"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="703"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="767"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="832"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1021"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1123"/>
            <end position="1132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1266925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1132" mass="124285" checksum="31477C3E2601C89C" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CDI4</accession>
    <name>A0A812CDI4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_31453</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001293">
        <property type="protein sequence ID" value="CAE1258973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CDI4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1258973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="248" mass="26843" checksum="F12DFE958B892082" modified="2021-09-29" version="1">MNPPSKTPDHRQPKCLKKGDMSRGPNSFPSSVKGHWPTISPESLNSRIDLPFASPSKTRLSPATIDEIISGFDPCRQHPLSICKCPKCLPPTRLFLPSVTLRNRDTISEMSPANVLSLEEQTIGRAAQKTPLPPTAVHRRHPHFWRRLSTNVARCGARLSPSLKGLLSLLEGVAPFPLQFRCCLSHIGGAAFLLPFQTSSLTDSGRGGHVLLVTCVTQTDGAPLAEGVLRLSVLSTAVCHDDPDGINP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CFX9</accession>
    <name>A0A812CFX9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_34557</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001469">
        <property type="protein sequence ID" value="CAE1265168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CFX9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1265168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="150" mass="17082" checksum="4C874305875413C2" modified="2021-09-29" version="1">MSSNDLGNLFLSIYLSIYLSIYLSIYLSIYLSIFFSLFLSIYLSFFSLFLSIYLYLFSVYFYYLSFFSLYLSINLFQPPPDLAQNQGSSQEFAATKYHDCLQYLEIIFSFSHVIVCLPTSLAPSLSLSSTALCLPASLSHLKGSLNICLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CGR5</accession>
    <name>A0A812CGR5_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mab-21-like nucleotidyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_35718</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001550">
        <property type="protein sequence ID" value="CAE1267721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CGR5"/>
    <dbReference type="OrthoDB" id="6054650at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046903">
        <property type="entry name" value="Mab-21-like_nuc_Trfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03281">
        <property type="entry name" value="Mab-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Mab-21-like nucleotidyltransferase" evidence="2">
        <location>
            <begin position="6"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1267721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="254" mass="30302" checksum="6BAAF49BDE157AD5" modified="2021-09-29" version="1">MNSGSYYSNVKVSNSNEFDYMFCPTFIQCRIEQYLPRPNYCHVFVTNKMKLPLEFQELLGPDDELSPSKFKEYVFSVFDYIVRETYNNQLTRKNTYSLNPAYTVEYKYGSSDIDIDWAPCLEVQEWPDSCMEWKTKMLTDEEKMDTKLYKISIYLSIYLSATKMKEKNIYLSIYLSIYLSIYLSKISKTYLSIYIYLSIYLFYLSIFHLSIPKNFENFKKISIYLSIYLSIYLSIYLSIYLSITKMKESLEITT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CI68</accession>
    <name>A0A812CI68_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WDR59</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SPHA_36451</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Farmed</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat WDR59 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001594">
        <property type="protein sequence ID" value="CAE1269218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CI68"/>
    <dbReference type="OrthoDB" id="6265621at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035859">
        <property type="term" value="C:Seh1-associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035591">
        <property type="term" value="F:signaling adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049567">
        <property type="entry name" value="WDR59-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46170">
        <property type="entry name" value="GATOR COMPLEX PROTEIN WDR59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46170:SF1">
        <property type="entry name" value="GATOR COMPLEX PROTEIN WDR59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00591">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="102"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="188"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="RWD" evidence="6">
        <location>
            <begin position="375"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="594"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="597"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="607"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAE1269218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="916" mass="103504" checksum="8C452ADB51C0CB77" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CIL5</accession>
    <name>A0A812CIL5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_38174</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001725">
        <property type="protein sequence ID" value="CAE1273451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CIL5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1273451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="216" mass="25171" checksum="2C6EDFE26A17FDAA" modified="2021-09-29" version="1">MYRETKSIVGDFLRSECRKDTAQRGKCLEFFIFNCGASISYRRRLRICYKTQFVKLVWICVTTTVAVGSRGPVIVPEVSFSRNIPLPPSFFSPSPLSFFFLSLSLSLSLSLSLSHTHTRPHTHIFIRFLYLYLSCSFTLCFSYYPLYTSNFYFLSISLLSLFHFFFLFSFFSLSFFSSFILSFICLSFLFFLSSSLFMNSCFSTNFSFFHSPLFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CJ26</accession>
    <name>A0A812CJ26_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_35731</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001551">
        <property type="protein sequence ID" value="CAE1267757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CJ26"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1267757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="182" mass="21988" checksum="68291E1C902FC1AA" modified="2021-09-29" version="1">MCQVSAPESTTIEYCCFYKLLHKDKSIYLSIYLSIYLSIYLILFITIFQYLSIYLNLSIYLLSINLSIYLHSHFLLSFYLSIYLLWFIYLSFILSIHNLSIYLNIFSVCFIIYHIYLSISVFIFYFISIYLLFIYLSIIDPQTNLFFLYHFSSSFYVFLFLHSSDCSFFIHPFIRRHYISDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CJT2</accession>
    <name>A0A812CJT2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_36010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001558">
        <property type="protein sequence ID" value="CAE1268149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CJT2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1268149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="305" mass="36845" checksum="E09CB4881AB0BBEE" modified="2021-09-29" version="1">MILLLLLFLFIYLLLLLLLLLLLLLLLLLLLLFFFFFILFFFSVCTFPAFFFITFYFFLSPTSFHFLSFFLSFFLSSSFILLFYIFFTFVFFFSSFFFAFLLWFFCLFYVFLLHIFYFHCLRLFYLRCFIFYAAFSFSFICFVTFFLFFIFFLSSFFSFFFLRFVILFLKLFSPSLLFLFAYFCISFSTFLLFCFHPFFVCLFVSFFFLLLLLALPLFLAVYQLPVPSLLFHLLPFLYAHILPPLFLTFSIASYFSFIYPVKLPFHIRPSILNKFNLHCHHYPPFSPALSLCFLISLSFSMPSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CKJ8</accession>
    <name>A0A812CKJ8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_35398</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001522">
        <property type="protein sequence ID" value="CAE1266930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CKJ8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1266930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="228" mass="27689" checksum="E6E8442D54D9EF35" modified="2021-09-29" version="1">MDNFNTILSLSLSLSLSLPLSLFLFLPSFSLSFFLMYFLFYLLSFFNFLQPFFFLPHYFLSFSSVSFFLSFFNLFFLFPPPLSLFRSSLIFSFFFLRLFLSFFLNLFFFFLPSLSLFLSSLIFSFFFHRHFLSSLMFSFFFLRLSFFLSFFLSFFLSFFLLNLFFLFPPSLSFFLSFFLNLFFLFPLPLFFIPRLSFLFPSFYFLRSYHLSLFSFLTCFPVDYEFIPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CKY4</accession>
    <name>A0A812CKY4_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7041 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_39443</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001832">
        <property type="protein sequence ID" value="CAE1275401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CKY4"/>
    <dbReference type="OrthoDB" id="6159822at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055469">
        <property type="entry name" value="DUF7041"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327">
        <property type="entry name" value="ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327:SF3">
        <property type="entry name" value="RNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23055">
        <property type="entry name" value="DUF7041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7041" evidence="1">
        <location>
            <begin position="27"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1275401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="180" mass="20518" checksum="F5143E60CBF57147" modified="2021-09-29" version="1">MESAKSDSLDMTAAIIPLPAYHHNAKNWFLQVESIFSMLRITSQRARFANVMQKLPSVMMDEISDVLSDLREHEPYDHLKEAILKLTGRSEEDMIQEILRNVTRGDKTPSQLLRYMRNQLGKYNVSEKVLRGLWLEHLPKSVAQIIAPMTRATPLDDLAESADLVFAQFDHSVNAVRAPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CN06</accession>
    <name>A0A812CN06_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_38579</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001757">
        <property type="protein sequence ID" value="CAE1274032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CN06"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1274032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="234" mass="27353" checksum="B0CBB9AEBA88157A" modified="2021-09-29" version="1">MSLSPSFILLTPLFHAACCLFLFGFNTLFLSLSLSYFFLFLFPHIVLVLTLISVSFFLSFFLSFFLLMPVPRLAVSFSSSTFLPSSIFYLIFLFHIQTFPFSLLNAVFLCVNVVYFSRLLYPFLPSSFFSITFTFILFFCRFFLMFSLAFFFFFLFSAISQIPSLSSFLYFSFLVISFYRVPRLISPLIHYHFIQLITIILSLRPPLLLLNSNCHPNTSYRQQHYNNNNSSLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CNM3</accession>
    <name>A0A812CNM3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_38153</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001724">
        <property type="protein sequence ID" value="CAE1273310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CNM3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1273310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="244" mass="28634" checksum="8AC342616C62BC5C" modified="2021-09-29" version="1">MREDITCFGIAASLSLSPPFPPSLALNLFIIYLNLFIIYLSIYLSISICSLSISIYLSLSVSLSLCLSLSIYIYICRYFLIIYLSVYLNLFIIYLNPFIIFLSHSVHYLSITICLLSSSICPLSIYFNLFIIYLSIFVHYLSIYLSIYLSLSLSIYIYIYIYIYIYILLFTHYLSQSVHYISFYLAISIFHYLFQFFHYLSIAIFSLSIYLSIYLSIYLSIYLPVCLYLFNVYLSIYLSIYLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CP85</accession>
    <name>A0A812CP85_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PITH domain-containing protein GA19395,PITH domain-containing protein CG6153,PITH domain-containing protein ZK353.9,PITH domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_41048</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PITHD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001961">
        <property type="protein sequence ID" value="CAE1278104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CP85"/>
    <dbReference type="OrthoDB" id="2635at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045654">
        <property type="term" value="P:positive regulation of megakaryocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060255">
        <property type="term" value="P:regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080090">
        <property type="term" value="P:regulation of primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.470:FF:000002">
        <property type="entry name" value="PITH domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.470">
        <property type="entry name" value="PITH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045099">
        <property type="entry name" value="PITH1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010400">
        <property type="entry name" value="PITH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037047">
        <property type="entry name" value="PITH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12175">
        <property type="entry name" value="AD039 HT014 THIOREDOXIN FAMILY TRP26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12175:SF1">
        <property type="entry name" value="PITH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06201">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51532">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PITH" evidence="2">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1278104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="171" mass="19569" checksum="6305750993C29003" modified="2021-09-29" version="1">MCLNEAVDSSGKLVFKPWDERLDREKFVDSDVDEELLFNIPFTGHIKLKGIIVIGGGEGMDPSKMKLYKNRPSMTFDDVSTEPDQEFDLNPDPDGQLEYPTKVARFNQVEHLTIFFSTNFGAENTRIHYIGLRGEFTEMRRHGVTICNYEAQANPMDHKSNLLNKMGHVIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CQY0</accession>
    <name>A0A812CQY0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_41800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002019">
        <property type="protein sequence ID" value="CAE1279448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CQY0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1279448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="184" mass="20505" checksum="E5F555786809B724" modified="2021-09-29" version="1">MLISTAYINKFKTVHFFEQPLYSFFFSSSNFSSHSSTSSSPSNTTTTTTIPTLYATPHYTRSSPSFLSTSFSIHSFSSSSIFSSSFFSIPPISSSSSSSSSSSSSFHSYYFSSAYFTSSSFFVFPSLVFSTSSSLLFLLHLLLPLLLLLLLRLLHILILFLRLFPLILHRVLLLPHILLLLLGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CRM9</accession>
    <name>A0A812CRM9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_40886</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001944">
        <property type="protein sequence ID" value="CAE1277815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CRM9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1277815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="392" mass="45755" checksum="6F9FDBB7F7D7B6C7" modified="2021-09-29" version="1">MKLNFILGDVVTCCYFFFFFLSFFSFFFFFLFFLSFFSFFFFFLFFFSFFLSFFFSFFFLSFFFLFFLSFFSFFFISFFFFLFLFFSFFFSFFFFFFIFFFIFFLYFLSLFFFFIFFLYFFLYFLFFYFLFFIFFLYFLFYFLSFIFFLYFLFLFILPLEEFKTFLTPSARKPLSSVSFSLSLQCLIFSLSPVSPFLSLSSVSFSLSLQCLLFLSLSSVSFPLSLSSVSFSLSLSSVSFFSLSPVSPFLSLSSVSLSLFSLSLSSVSFSLSLSSVSFFSLSPVSPFLSLSPVSPFLSLSPVSPFLSLSPVSPFLSLSPVSPFLSLSPVSPFLSLSPVSPFLSLSQCLLFLSLSSVSFSLSLSLSLPPPLIFFFLAFSPSCPQFPSPHFSHYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CS58</accession>
    <name>A0A812CS58_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CRN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SPHA_43834</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the crooked-neck family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002223">
        <property type="protein sequence ID" value="CAE1283064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CS58"/>
    <dbReference type="OrthoDB" id="541719at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045075">
        <property type="entry name" value="Syf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246:SF3">
        <property type="entry name" value="CROOKED NECK-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAE1283064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="471" mass="55615" checksum="3B892DCF9C908815" modified="2021-09-29" version="1">MAEVTPGGKTKMPKVAKVKNKMPAPVQITAEQLLREAKERELELVPPAFEDNIRKNRTVMSNWIKYAQWEETQKEIQRNRQINHARNIWDRAVSILPRANQFWYKYTYMEEMLGNVAVHALFYPQCLHFQVWIFFSCMLSLSFFLSARRVYERAVEFFGQDNIDETLLIAFAKFEEGQREEVKANPMNYDAWFDYLRLLEADGDVEQIREVYERAIANLPPSQYAELEAILGDKERARGIYELAINQPKLDMPEVLWKSYIDYEFEQEEYARTRNLYRRLLQRTQHVKKEVGDEASERMVMKLMPQKIKKRRKIHTEDGSDAGWEEYFDYIFPDEESAQPNLKLLAMAKKWKQMQETKKDNDDRTLRSNLFRHFLPSQRSPVYHYRLLFPSFSSSDSTFARLSPVSTLARLLSSVSLFRLNANPFARSPGPTLSALFKKFLPNKDIADFIEDFIYLSIYLSIYLSIHAYAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CT94</accession>
    <name>A0A812CT94_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_43023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002131">
        <property type="protein sequence ID" value="CAE1281725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CT94"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1281725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="205" mass="24922" checksum="DF660095D660D223" modified="2021-09-29" version="1">MDIFLKSIFYLYLSIIYLNNLSIFFFFFFYYSSYAFSIYLSSNLSIYLSIYLKNFYIFYYLFIYLIIYLSIYIYLSIINSNNHILNFKYLLSIYLSISIYLSIYLSIYLSIYLYNYLSIYLSIYIFYLSIYFYLSIAYSFIYLSIYLSIYLFHASIYLSIYLSIYLSIYLSKAFFYVSTPFDLSIYLIPCTSIYLSIYLSIYLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CW57</accession>
    <name>A0A812CW57_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_40944</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001949">
        <property type="protein sequence ID" value="CAE1277946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CW57"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141571">
        <property type="entry name" value="Pentapeptide repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1277946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="199" mass="22785" checksum="2BF761633BEEF441" modified="2021-09-29" version="1">MQETPSIRVLGEGRRRSYSLLLFSDVWRPDASSSQVSISTGSISTGSKLPDLYLTGLYLPGLYLSGLYLAGLSISTGSVSTGSISTGSKLPGLYLPGLYLPGLYLPGLYLTGLYLPGLNYRVYIYRVYLYRACIYQVCIYRVCIYRVYIYRVYIYRVCIYRACIYRVYIYRVYIYRVYIYRVCLLGLYLPRVTAKLSNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CWM1</accession>
    <name>A0A812CWM1_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PCNA-interacting partner</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">PARP-1 binding protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">PARP1-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SPHA_46144</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PARI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002423">
        <property type="protein sequence ID" value="CAE1286685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CWM1"/>
    <dbReference type="OrthoDB" id="6427080at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000042">
        <property type="term" value="P:negative regulation of double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.486.10">
        <property type="entry name" value="PCRA, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038932">
        <property type="entry name" value="PARPBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32121">
        <property type="entry name" value="PCNA-INTERACTING PARTNER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32121:SF0">
        <property type="entry name" value="PCNA-INTERACTING PARTNER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="562"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="570"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAE1286685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="624" mass="71126" checksum="331B712ED4880664" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CXA3</accession>
    <name>A0A812CXA3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_41525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002000">
        <property type="protein sequence ID" value="CAE1278934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CXA3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="178"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="290"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="322"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1278934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="348" mass="44377" checksum="7B98ABFBDBFDDB65" modified="2021-09-29" version="1">MLISYLSFFTFLSVSFFSFNLSFLSFYLFKFSLQFSEHFLWFLPYLFFLYFLFQNLISHLSFSFFYYFLNIHFSFFSFFPFIWDVIFYYTFNFILFFFILFIFFLFFSFFSFFFIFLYKTFLISFFSFFFSFFLFFLLFLFFIISFFFFLFFFLTLLIFNIFFLFFLFFPYFFLYNCFISFLFLFIFFFLYLLFSSQTFFYLFPSKNLLSHCFLFFLYFNISFLLSFFPFHFFSFFSFFFILYFFLNSFFLPKSFINIFLFSELLYIFYLFFFFFLYLKEMGWGRIEKFHFLTVSFFFLSFLLYFLAVLVTIIHFFSYLFFLSFYFVAEFYYSFLFFLFFSFFKFDFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D0Z2</accession>
    <name>A0A812D0Z2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_46845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002501">
        <property type="protein sequence ID" value="CAE1287911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D0Z2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1287911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="182" mass="21159" checksum="817C044C97EF87C7" modified="2021-09-29" version="1">MLTTFVYFLISFKDFQLKYYEHISTLPSLTHYLSSLSVHLIFIISIYLSPFIIYLSIYLSPFIIYLSIYLSIYLSQSVHYLSIYLSQSVHYLSIYLSPFIIYLSIYLSISVCSLSIYLSISARSLSISISARSLSIYLSQPVHYLSIYLCIYLSIYLSPFIIYLSDLFIYPVHISLYSYVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D3A2</accession>
    <name>A0A812D3A2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_46338</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002445">
        <property type="protein sequence ID" value="CAE1287018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D3A2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1287018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="291" mass="30506" checksum="A763D4B91AA6075F" modified="2021-09-29" version="1">MGWGSTMRAEETDNLFQSGRLAVALRCLVCWRWLSGVWSAGGSSQVFGLLAVSLRCLVCWRCLSGVWSAGGVSQLSGVWSAGGVSQVFGLLAVALRCFGLFGGVSLRCLVCWQCLSGVWSAGLSGVWSAGGVSQVFGLLAVSLRCLVCWRCLSGVWSGGGVSQVFGLLAVFSGVWSVGGVSQVFGLLAVSLRCLVCWRCLSGVWSAGGGSQVFGLLAVGSQVFGLLAAALRCLVCWRWLSGVWSAGGGSQVFGLLAVALRCLVCWRCLSGVWSAGGGSQVFRHCHIRPLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D4P5</accession>
    <name>A0A812D4P5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_47266</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002556">
        <property type="protein sequence ID" value="CAE1288757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D4P5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="314"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="357"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1288757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="403" mass="47545" checksum="5596426657F47484" modified="2021-09-29" version="1">MFSFFILSIFLTFHLFSFFPFLSFFLIFVPTSVSLFLYCFLYIFLFLSFFLSFFLSFFLSFFLSFFLSLHIFLYSHFFLSFFLSFFLSFFLSFFYILDPTIEHFKFWNFHIAIFTKTGTFLKTSDIHLILPSFWCDLRTLGFWFKFNSLLCCLFFSFLSLSFYSCLFVLFFFSNLINFFFPQNFSLLLSSSLYLSICSLFSPQIFSLLLSLSLYLSICSFLLRSSLFFSHPLSTLAFVLSFLLRSSLFCSHPLSTLAFIFSLLLSPSLYLNICSLFSPQIFSLLLSPSLYLNICSLFSPQIFPLSVFFSNLINLFFSPIFFLCNFFHLFLLSFFAFLSRFSFFSLPLTEFSFPHVEYSSFFFFSPCSYIVFFLTTISHIYLSFSFCLPFFDLFSISLSLSLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D4U4</accession>
    <name>A0A812D4U4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">E3.6.1.52</fullName>
            <ecNumber evidence="1">3.6.1.52</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_48722</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.52" evidence="1"/>
    <dbReference type="EMBL" id="CAHIKZ030002729">
        <property type="protein sequence ID" value="CAE1291357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D4U4"/>
    <dbReference type="OrthoDB" id="2011998at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008486">
        <property type="term" value="F:diphosphoinositol-polyphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1291357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="748" mass="80785" checksum="5EE1DB17B2558394" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D583</accession>
    <name>A0A812D583_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_47314</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002556">
        <property type="protein sequence ID" value="CAE1288731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D583"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="305"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1288731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="338" mass="40416" checksum="55FCB0C59CC23692" modified="2021-09-29" version="1">MRLFISIYLSIYLLSIYLFINLSASLSIYLLFYKYIYIFIYIYIYLSLYISIYQSIYVSVYLSLYISIYQSIYVSVYLSIYLSLFLSSNFHIYLSIYLSIYLSIYLSISVFFISIFKFSHLLHLSIYLSIYLSIYLSVFFFLSSNFHPLSIYLSIYLSISVFFISIFKFSHLSIYLYLSIYLYLSIYLSLFSLFLSSNFHIYLSIYLSIYLSIYLSISVFFISIFKFSHLSIYLSIYLSIYLSIYLSLFSLFLSSNFHIYLSIYLSIYLSIYLSIYLCFLYFYLQIFTSIYLSIYLSIYLSCNSLFYGLFVLLPSLSIFPFHLLVFFSLSDKHVHKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D684</accession>
    <name>A0A812D684_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_47791</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002622">
        <property type="protein sequence ID" value="CAE1289695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D684"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1289695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="325" mass="37771" checksum="59B5DD5539BB6F08" modified="2021-09-29" version="1">MLSHLFLSFHFFYSPSPSLPSLFLSLVAFSYVSDMHLSLLFSAYLSSSLSLSPLLLSSFISLFLYLSLIFLFFSPFLSCDEFSDWPMICLPRFHLARQLRNSLSLYLSLSLSLSLSFSLSLSLSLSIYLSIYLSIYLSIPAFFFFRSLCFSVYPPQLFSFSFLSFEHLFFLAFSIFLFLSQLLSLFFHFFFISCSLNVSQSLFLIHFFSLTLPFSLNIFIVSHFLSLSLSLSLSLSIYLSIYLSISHTHPHTHSLFLFIYQYILLLLPYSLFFTTLYLSLFFYFSLYRSHFSFFIFSLSLFLSLLLSLAHTHARAHIHTLSFLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D760</accession>
    <name>A0A812D760_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_46455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002452">
        <property type="protein sequence ID" value="CAE1287241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D760"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1287241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="240" mass="27667" checksum="73998883BBE6525D" modified="2021-09-29" version="1">MSKYGDGSYTHSLPVFLRAFDIFNAILPPSFYVSLFFHFSFHFFSLSLSILLLSPSFYSPSFLSLPLSLFSFSLSIFLSFPHFRFSSPASVLSSPFFSFTFLLFLFLSFSIFLNFISLFYISFLLILLPPISSSFLFSHFSPTPPTFILGSFLLFSFFFSSSPPFPSFRFFPFSLFLSPATHFYFSPRLFLLFFSPSLLFSFLLFYFSSISSFSHSFLLPLLFSPPTSPILFSFSFHLRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DCS0</accession>
    <name>A0A812DCS0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_50423</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002966">
        <property type="protein sequence ID" value="CAE1294498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DCS0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1294498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="160" mass="18890" checksum="54A1F3CB341416C3" modified="2021-09-29" version="1">MTQIKSINIHLPSPSTVSHTLFRRLPHSLQKPCPRFLWALLRENGRRFIDCLFFFFFFFFFFFFFFTTPTTQFQPPQSLDPHLNSPIQPVVTTKYQPSLSLSLSLYLSIYLSIYLSIYLSIYLPLVFSVTNLLLAESGKEAYQIRFSSPFVEEWNCQNIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DDL6</accession>
    <name>A0A812DDL6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ODF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SPHA_51467</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ODF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003117">
        <property type="protein sequence ID" value="CAE1296486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DDL6"/>
    <dbReference type="OrthoDB" id="413404at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902017">
        <property type="term" value="P:regulation of cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026099">
        <property type="entry name" value="Odf2-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23162:SF10">
        <property type="entry name" value="FI13205P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23162">
        <property type="entry name" value="OUTER DENSE FIBER OF SPERM TAILS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90257">
        <property type="entry name" value="Myosin rod fragments"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="47"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="99"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="265"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="599"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="740"/>
            <end position="767"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAE1296486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="817" mass="95818" checksum="F27262DFC76D509A" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DFA5</accession>
    <name>A0A812DFA5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_54773</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003595">
        <property type="protein sequence ID" value="CAE1302025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DFA5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1302025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="254" mass="28252" checksum="94B23A1CA2AB7A9E" modified="2021-09-29" version="1">MRPISSFLSNGRGSLTVIIPKPLPPATTRVDSFLPQAHTDDDNQILSLLCSSPTLSLCLLILSLIPSNIIHYLMTLLFPHPLPVSSQSLPYPFQYNSDDPLSHDTALPSPFACIFSFSPLSLPNNSDDPLSHYTALPSPFACIFSFSPLSLSNTTQMIRYRMTLPFPHHNPLSHDCSSLTVCLYLPILSLILSNTTKMIRYLMTLFFPHPLPVSSHSLPYPFQYNSDDPLSHDCSSLTLCLYLLILSLIPFNTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DFJ2</accession>
    <name>A0A812DFJ2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_51897</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003183">
        <property type="protein sequence ID" value="CAE1297279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DFJ2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1297279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="268" mass="32420" checksum="A11BC07860CDCC3D" modified="2021-09-29" version="1">MYLLLFVFLSFSFFSFVFYSFLLRLYSFYSSFLLFLYAFVCSSFSFSSLVLYSFLFNLYFLSFSFCFFLFNFSFLFSFPLPFPYSHSVFFRFSLCFSFIFFILFFFFNLSLVPSSFLSFLLLSLFHSCTSFLLFFFLQLFDIVLFRLILTFLPPVFSFFFLFIPSLFSFLSFLLLSLYLSNTLFFPFIFFIPFFFIPLIPLHFAFTSFIFLSCTLFFLLYLYSALSLIHSFSVFRSFPFFILLYSFLLHFAYCVLFFKMMNKKSFLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DFJ7</accession>
    <name>A0A812DFJ7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_54377</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003536">
        <property type="protein sequence ID" value="CAE1301363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DFJ7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1301363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="241" mass="28896" checksum="0502AE527A922B44" modified="2021-09-29" version="1">MWLNKWHAYDSVSFLYLFLSFFLSFFLSFFLSFFIFSISFFSLSLSFSVSFSFFLYLFRSLFFLSPSFSLPFFSLFLFCFFFFLSFFLCFSLSLFLSLFSLSFFFLSLFFILSFFISFIRSLFLVSFSLSLFLSLSFFYLSLLYLFLSFSLSFLSLSFSLLLSLSFFYLFLSLFFSISFSLSFRYLFLSLFHSFPLFFLCIFLSSISFSLLLFQYPVTLISLTEGEDIFLFCEFFRPHPFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DHG2</accession>
    <name>A0A812DHG2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_56822</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003794">
        <property type="protein sequence ID" value="CAE1304184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DHG2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="196"/>
        </location>
    </feature>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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        </source>
    </evidence>
    <sequence length="382" mass="42544" checksum="7D2046D04E0E4756" modified="2021-09-29" version="1">MYNLPNLNLCILLFTSFAVVISYLFCNNLILLYHFCCSLFATDLLSLFLPLLYFLSLSVAPFSISLPPIFFHYHSLPMCSFFIAPYPCSYFSHCLLASAPFSLSRCPASHSLSLLASAPLSLSLCLYSSFFLSLPLCLFLSLLLLFFFSLSLPCFSFSLPLLALALLFRSLFSTLFLLWILPLIFFIFSPAPPLCSSHLLLLFSSSHLLLLFFLLSPSAPLFPPLTFCSSFSSSHLLLLFFLLSPSTPLSLSFCAAPLSSFFLPLSSFFPLSLSCSSFFLSLSCSSFFLSLSLVPLSCSSLSLCLPISPHSSIAPHSFLLYPVHTPLFYLSLLLSAMSTSFFIYFFFTFLLFYLHFSSILPLSLHTSTILCANILFFARNIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DPA7</accession>
    <name>A0A812DPA7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_60007</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004155">
        <property type="protein sequence ID" value="CAE1307954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DPA7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1307954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="212" mass="25245" checksum="81F96D90EB2C1D8E" modified="2021-09-29" version="1">MIVYFFTSYFCSFFLLSSFFSLFHFLSFLSLFVFSALFQISIHIFPLSFFPFSVFFLLSFFLPLFFKRVHYTQTHTSYLSPFSFFSSIMSLSFKQAHIYTLPFFFLSFFLVVFTSLFQRSTHIHTPFLLFFSLSFYCYLSNRHTRTHTTLQTFIFYAFPDFIFSSCIFLKFCPSNLLFLPCNLFSLSFSLSHTHVRAHVHSHTRTHVHSPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DRB7</accession>
    <name>A0A812DRB7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="15">IFT140</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SPHA_59874</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004150">
        <property type="protein sequence ID" value="CAE1307905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10258787at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030991">
        <property type="term" value="C:intraciliary transport particle A"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035721">
        <property type="term" value="P:intraciliary retrograde transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.470:FF:000011">
        <property type="entry name" value="Intraflagellar transport protein 140"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056154">
        <property type="entry name" value="Beta-prop_IFT140_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056155">
        <property type="entry name" value="Beta-prop_IFT140_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011048">
        <property type="entry name" value="Haem_d1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056168">
        <property type="entry name" value="TPR_IF140/IFT172/WDR19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056156">
        <property type="entry name" value="TPR_IF140_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15722">
        <property type="entry name" value="IFT140/172-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15722:SF7">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 140 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23383">
        <property type="entry name" value="Beta-prop_IFT140_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23385">
        <property type="entry name" value="Beta-prop_IFT140_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24762">
        <property type="entry name" value="TPR_IF140-IFT172"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24760">
        <property type="entry name" value="TPR_IF140_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51004">
        <property type="entry name" value="C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0969">Cilium</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0853">WD repeat</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032593428" evidence="10">
        <location>
            <begin position="17"/>
            <end position="1901"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1206"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1233"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1287"/>
            <end position="1305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1343"/>
            <end position="1367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1374"/>
            <end position="1392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1404"/>
            <end position="1425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1437"/>
            <end position="1461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1880"/>
            <end position="1898"/>
        </location>
    </feature>
    <feature type="domain" description="IFT140 first beta-propeller" evidence="11">
        <location>
            <begin position="43"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="140"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="IFT140 second beta-propeller" evidence="12">
        <location>
            <begin position="462"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="domain" description="IF140/IFT172/WDR19 TPR" evidence="14">
        <location>
            <begin position="850"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="domain" description="IF140/IFT172/WDR19 TPR" evidence="14">
        <location>
            <begin position="1485"/>
            <end position="1667"/>
        </location>
    </feature>
    <feature type="domain" description="IF140 C-terminal TPR" evidence="13">
        <location>
            <begin position="1675"/>
            <end position="1799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="667"/>
            <end position="700"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF23383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF23385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF24760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF24762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAE1307905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1901" mass="213940" checksum="6E5DFB1133207EEF" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DS93</accession>
    <name>A0A812DS93_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_59803</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004146">
        <property type="protein sequence ID" value="CAE1307784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DS93"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1307784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="239" mass="28825" checksum="CAD58E2D77222C98" modified="2021-09-29" version="1">MIMVGEMTGRVALLRPPDSPGEASQISLSLFLSFFYLQSLFFLSFFLSFFLSLNFTLSFFELFFHPFSFFASFFLSSISVYTSFSRSFFLPSFFLLQLIFYFILSFVLSLVRCFFLLLQFKITFYFSFIHSTAIFIDFLIYNLCYSSFFFLSFFEFSLPSLCFSHNFLLSIFFFHLFRFFFISFSLFILFYFFFRFFPMLMTSDFFFIRHTGYKYNFFVVFFLSFFLSFSMNMSTFSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DT01</accession>
    <name>A0A812DT01_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_59807</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004146">
        <property type="protein sequence ID" value="CAE1307820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DT01"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032776484" evidence="2">
        <location>
            <begin position="18"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1307820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="475" mass="50267" checksum="43FBA158FCD82D3D" modified="2021-09-29" version="1">MFPLIVFLFHFFCSVHCSLSHFPCLSFLAALSFPPSALSFSPPLLSFSPPLLSFSPPSLSPPPALSFSPPPALSFSPPSLFPPPLSPPPLLSLSPLCSLFLPPPLLSLSPPPSALSFSPPLLSLSPPLCSLFLPPLSLFLPPSALFSPPPSALSFSPPLLSLSPPLCSLFLPPSALSFSPLCSLFLPPSALSFSPPLLSLSPPPLLSLSPPPLCSLFLPPPLLSLSPPPLLSLSPPSALSSPPPLLLFLSSHPSLLSTPSALPPPSISALSFPFPLLYIAIPLSLTVWFSLYYSFSLFFFSLVYFFLSLFFCSPVLSLSLSFSARPSCLSPPLSFCSPVLSRPLSFCSPVLSLSPPVSPPPSLSARPSHKPSLHFLPLSLSPSHCISSHSLFIVPLTAFPPTLSSYPSHCISSHSLHSPSHSLFIVPLTLSSYPSHSLFIVPLTLSSKSLSVPLIVLSLHSPSHSLFIVPLTLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DVI7</accession>
    <name>A0A812DVI7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_61604</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004372">
        <property type="protein sequence ID" value="CAE1309949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DVI7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1309949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="261" mass="30994" checksum="05E619F821329FB5" modified="2021-09-29" version="1">MYVYLPLILSIYLSIYLSIYLSIYLCSFVIRTFSLHEKNLRDRVVLTIEALFHAQLQFSHLVNTIYLSIYLSIYLSIAVVFFPSFLLSIYLAVVFFLSFFLSFFLSFIYLLSFFLSIYLSIYLSIASFFLSFFLSFYLAVVFFLSIYLSIYLSIYLSIAVDFFLLSISQSFFSFFLSFFLSFFLSFYLSHSVTIYLSIYLSIYLSIYHILSIYLSIYYLSIYLSIIILLLFIYLSIYLSIYLSIYLSISDYSDYFRCHSVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DVL9</accession>
    <name>A0A812DVL9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_59375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004111">
        <property type="protein sequence ID" value="CAE1307311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DVL9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1307311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="328" mass="38588" checksum="D140FC4748DBD3CC" modified="2021-09-29" version="1">MILQLFGKNHSIFYCLKTILKYLSIYLSIYLSIYLSIYLRLLKSIYLSRYVHIYLSIYLSIYLSIYLSISVHFNTIYLSIASCSHLSIYLSIYLSIYLSIYLSPSIYLSIYLSIYLFTSIYLSPIYLSIYLSIYLSIYLSIYLSIYLSIYLSIYLSIALFPISLLHSSQEREQRTVHDLVMRWDLEVSDSVQSRTCSAPTRNIVGSRPNKVRLKGHGRSNDYTSTDNLQFLQSACFSFFLYLFHHTSPVFLSFFLFALVIFLYIFFTSFSSFSSSSLLFPAIFHCSFHSYFSLLFTPFWYFSVFLFHFISFFLTHSHLSGFFFFKLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DWT0</accession>
    <name>A0A812DWT0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_61282</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004328">
        <property type="protein sequence ID" value="CAE1309627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DWT0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1309627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="221" mass="27002" checksum="83854FE966AB9411" modified="2021-09-29" version="1">MISIYLFVFLTRSLISISFFPLSFFLSFFLCFSFFLSFFLSFFLSFFLSFLLSNFPLFFLTVFLFFTFFLSFFLSFFFQSIIFQFSSFSSLCHLSIHSFSFLLTPVIHSSVFPFSLYLASFLLLSLTVPSFFFTFFSCIYFLQLLSFFLSFFLSFFLNSFYISLDFTFLYRPFFHSFSFFLSFLSFFFLFKFFYIPLDFTFLYRHLLSFFFFFFFFLSFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DX96</accession>
    <name>A0A812DX96_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RB1CC1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SPHA_64181</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004620">
        <property type="protein sequence ID" value="CAE1313011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="447953at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990316">
        <property type="term" value="C:Atg1/ULK1 kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061723">
        <property type="term" value="P:glycophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034517">
        <property type="term" value="P:ribophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17060">
        <property type="entry name" value="Ubl_RB1CC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040040">
        <property type="entry name" value="ATG11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019460">
        <property type="entry name" value="Atg11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045326">
        <property type="entry name" value="ATG17-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13222">
        <property type="entry name" value="RB1-INDUCIBLE COILED-COIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13222:SF1">
        <property type="entry name" value="RB1-INDUCIBLE COILED-COIL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10377">
        <property type="entry name" value="ATG11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04108">
        <property type="entry name" value="ATG17_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Autophagy protein ATG17-like" evidence="7">
        <location>
            <begin position="211"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="Autophagy-related protein 11 C-terminal" evidence="8">
        <location>
            <begin position="1356"/>
            <end position="1467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="686"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="761"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="920"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="1104"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="1192"/>
            <end position="1376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="697"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="761"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="782"/>
            <end position="792"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAE1313011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1522" mass="174158" checksum="391F8B2041C90F69" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DZS6</accession>
    <name>A0A812DZS6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_65204</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004700">
        <property type="protein sequence ID" value="CAE1314202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DZS6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1314202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="298" mass="35771" checksum="FC69FB983BF62AF9" modified="2021-09-29" version="1">MQPTALSLISISPLSSLMWETGLLSSTERKQCFALFNSFTVYSCHLGCIHYFHSFNLLNLSFFLSFPSFFSFFLSFFLSFFLSFPSFFSFFLSFFLSFFSFILFFLSFFLSFFLSFFLFLHSFLSLFLSFFFAFFLSFFLSLFIYLLVSMIFFLPFFVLSLFYYVFFLSFFLSFFLSFFLSFDLYFIDFKEIKDKKCFSFFIYLFFLFYLSIYLSIYLSISVYSYLSIYLSIYLSIYLSIYLSISVYSYLSQSIHIYLSIYLSIYLSIYLSIYRSLVISIYTSQFISIYLSIYLVSEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E3V4</accession>
    <name>A0A812E3V4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_65782</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004732">
        <property type="protein sequence ID" value="CAE1314764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E3V4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1314764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="164" mass="19522" checksum="A5B819C258DB7E7A" modified="2021-09-29" version="1">MFRSLSIVSAQTFHTYLIHPWIGPHYYPEIIYFLSFFLSFFVISTDFILICFFLVFSFWFSPSSSSSSSSSSFFLSFFLWLTYLYFFLFLLFAYLPSIFFFIIVASFFFLPIRNVQHFFFNPLPPFYFLFYVFFIVPTFFLSASYSISPPPPPSSYSTFLSHTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E496</accession>
    <name>A0A812E496_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_68056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004937">
        <property type="protein sequence ID" value="CAE1317503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E496"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1317503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="220" mass="23704" checksum="B038E1F30FFEB498" modified="2021-09-29" version="1">MAPTSHLLVRFFANSKLLPPPLPLSPIIFFSVLKTLLFRRTHLFSCCRSSSSSSFSPSSLLSSLTPSAPLSNHSLLLGFATLIVVPFSFSSLFFLPPTLIISPSLCILSFPSLPPLLNFLFIISQIDIHHTTSLLLSLSLLLTSLLLSLSLLLTSLLLSLSLLLTSLLLSLSLLLTSLLLSLSLLLTSLLLSLSLLFNVSLALSLSLLLTSLLLSLSLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E9J5</accession>
    <name>A0A812E9J5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_68158</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004949">
        <property type="protein sequence ID" value="CAE1317618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E9J5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1317618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="255" mass="30000" checksum="CA80F5D881C8F7E1" modified="2021-09-29" version="1">MQLVIYLSIYLSIYLSIYLSIYPSLFISIYLSQCIKIYLSIYLSIYLSISSCHLSRTGHLSIYLSIYLSIYLSESSSIYLSIYLSQSVHIYLSIYLSQYIHIYPSLFISIYLSIYLSLLKSIYLRLVIYLSIYLFKSVHIYLSISAIYLSTPIIYLSTPCHLSIYLNMDIYLSIYLSISIWTSIYLSIYLSILIWTSIYLSQYGHLSIYLSQYGHLAIYLFIYLCSKRRFVIFYFLEILQSNLTVGINFFSIKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EBQ8</accession>
    <name>A0A812EBQ8_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SPHA_71439</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005233">
        <property type="protein sequence ID" value="CAE1321346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="70030at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="186"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="245"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="276"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="306"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="335"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="403"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="432"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="467"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="495"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="525"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="563"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="599"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="638"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="679"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="707"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="738"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="2136"/>
            <end position="2157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="2164"/>
            <end position="2185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="2191"/>
            <end position="2214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="2226"/>
            <end position="2246"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="127"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="808"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1276"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1931"/>
            <end position="1950"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1995"/>
            <end position="2020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="839"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="870"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="936"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1288"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1931"/>
            <end position="1949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1995"/>
            <end position="2014"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAE1321346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="2249" mass="253714" checksum="D1387294735145D1" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ECK2</accession>
    <name>A0A812ECK2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_72639</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005336">
        <property type="protein sequence ID" value="CAE1322698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ECK2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1322698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="175" mass="20392" checksum="0CE11BED9836BEAC" modified="2021-09-29" version="1">MGDRLFFLSFFLSFVCSNLSIYLSIYLSIYLSIYLSIYLSIYLLFFASPLSFSLTLSLSLSLSLSLSPQWSFAQMEQQKRIFSTDNQSIYLSIYLSIYLSIYLLVSVLRFHAYLSAFTCTHTFWLIFIWRSIYFTLSIFISLWIYTSLSLSLSLSLSLSLSFLSQSEHYLSIYSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ECQ7</accession>
    <name>A0A812ECQ7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_71995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
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    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005285">
        <property type="protein sequence ID" value="CAE1321974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ECQ7"/>
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    </dbReference>
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            <begin position="63"/>
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            <begin position="90"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1321974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="165" mass="19076" checksum="D90C4A1AD561E97F" modified="2021-09-29" version="1">MFLALGARVVTQYLLFPPSLLISFSHTLFPSSFHLSIFHSLTHSLTIYLSISPSPSSTFVSLLLLYTLFFFSSGACLCIFLYPGSHSLNLSLYFPSPTFFFLPFVSLYIYLSMTYNLSIYNYFYLSIYICFYLSIYNYFYLSITISIYLSICICFYLSITVSIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EEU5</accession>
    <name>A0A812EEU5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_71259</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005215">
        <property type="protein sequence ID" value="CAE1321120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EEU5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
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        <location>
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        <location>
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            <begin position="104"/>
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        <location>
            <begin position="149"/>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1321120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="199" mass="23171" checksum="899F635B5C3045C5" modified="2021-09-29" version="1">MRFRLVRFLSLYFPFYFFITPFRYLFIFLSISLSFPFFLSIFFSLFLSFSSFLLSISFFLSFLLFRFLFFSFFVLFTGSFSITSCHSNNFPLSLHLFLFRSLSPIVYSFTSLSFYFSLSLSVSLFPLLRVVALPFCISHFYSPSLSSSLFYMHFSFFLLSAISLSISSCRFLTLHLSLSSSLLLPLSLFAVLFLSLLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EF64</accession>
    <name>A0A812EF64_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_70126</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005126">
        <property type="protein sequence ID" value="CAE1319809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EF64"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1319809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="159" mass="18288" checksum="CB5CB0C8CF697C97" modified="2021-09-29" version="1">MVRSEIVSDLTGDEISSIYLSIYLSIYLSIYLSIYFFSFQNFFFHSGIKLNVFVFCCFFLFFAFSLSLSLLSPFLSLSLSPFLSLSLSLSLSRFFFRSFFVSLSLSFFSRPLLFACHFLFLHCKDIIFVSGSFTGSHISFYLFALCCLCSDTKNANRLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EFI8</accession>
    <name>A0A812EFI8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_69902</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005110">
        <property type="protein sequence ID" value="CAE1319576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EFI8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1319576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="320" mass="37427" checksum="FCC22AD2E58A6FEF" modified="2021-09-29" version="1">MYSKRNEDFAFHCKNNLSIVRINIIFICKNNLSIVRIHIIFSCKNNLSIVRINIIFICKNNLSIVRIHIIFSCKNNLSIVRINIIFICKNNLSIVRIHIIFSCKNNLYIVRIHVIFNCKNNLSIVRIHIIFSCKNNLSIVRINIIFICKNNLSIVRIHIIFSCKNNLSIVRIHVIFNCKNNLSIVRIHIIFSCKNNLSIVRINIIFICKNNLSIVRIHIIFSCKNNLSIVRIHVIFNCKNNLSIVRINIIFICKNNLSIVRINIIFNCKNNLSIVRIHIIFSCKNNLSIVRIHQKPLSILSLSIYLSIYLSIYLSIYLYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EGC6</accession>
    <name>A0A812EGC6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_71816</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005267">
        <property type="protein sequence ID" value="CAE1321767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EGC6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1321767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="290" mass="35250" checksum="141DDA6736A70795" modified="2021-09-29" version="1">MYDKLYNTSLSYIHICLLHIYLSIYLSIYLSIYVRSSSSDTPFTFFLFQFCLFLPFFFFIFFTFPSFSFSSILFFLFIFLPFSLSFVFSIFSFTFPSFYFLPFFLTLPFPPFFFHFFSSIFLPFLFHIFSSFCFPPFTSFFPLFLLFHFLPFYFLSFFLLSPFLLIDFFSFSFSFVFLFLTFLFFFSFFYFFFLFTIPSFLFLSFFSFPHFYIFFRPFPFSSTFSFFLFLTFSFTFFTFSSTVSFSFSFVLLLSFLVFGPLFNALFLLRYFFSLHLFLLVKHLLLFASTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EIA0</accession>
    <name>A0A812EIA0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HemN</fullName>
            <ecNumber evidence="2">1.3.98.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_74945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.98.3" evidence="2"/>
    <dbReference type="EMBL" id="CAHIKZ030005443">
        <property type="protein sequence ID" value="CAE1325290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EIA0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051989">
        <property type="term" value="F:coproporphyrinogen dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1325290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="209" mass="22862" checksum="D3AC0776CD1C7E71" modified="2021-09-29" version="1">MKWRKKTLSLSKSLAYHLSLSPSTSLSFHLFLFPLLSFHLSLSPPLSSSTSLPFHLSLLPPLSPSTSLSFHLSLLPPLSHSTSLFFHLSLLPPLSPSASLSFHLSPSTSLSFHPSLLPPLSLSTSLSFHLSLLPPLSPLTLLFFHLSLLPPLSPSTSLSFHLSLLPPLSPSTSLSFHLSFFPPLSLFFHLPVIACVLIYISAFLIQRII</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EIZ1</accession>
    <name>A0A812EIZ1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_74614</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005435">
        <property type="protein sequence ID" value="CAE1324967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EIZ1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1324967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="315" mass="37750" checksum="20AFFDA85A26B2AC" modified="2021-09-29" version="1">MRSLSSHCSTFARSSNQRCYVVFPFSAPHSIPPLLADNSFACLFISTRSPIRSPIRSFLRSLLRTRFISFFSSLFPPVLLHYLFPSLTSLSITSFFLSFFLSFFLSFFLSRLVALSLSVPYFIIQSFFCIFLFLSFFFFLSFFLSFFLSCYIIFSFLNSLSFLSFFFRSLFLSFFLSFFLSFFLSFFLSNYYFKFHIFFASFYFSSLLICSFLIFFLSFFLSFFLSFFLQKKILLFSTSLRLSLFKSFFKFSLFFKLIFSHFHVFLSFFLSFFLSFFLFFFFLSFFLSFFLSFDSFLHFLSKYYLSIYLSIYLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EMD2</accession>
    <name>A0A812EMD2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_73864</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005398">
        <property type="protein sequence ID" value="CAE1324085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EMD2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="7"/>
            <end position="33"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="293"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="331"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="367"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="395"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="425"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="458"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="488"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="519"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="552"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="579"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="607"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="638"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1324085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="655" mass="79297" checksum="F8C99F7D41F5AF46" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812F285</accession>
    <name>A0A812F285_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_81306</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005630">
        <property type="protein sequence ID" value="CAE1332256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812F285"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1332256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="160" mass="18241" checksum="78C67D8F140D7E36" modified="2021-09-29" version="1">MERLSIYLSIYLGLFILYLSIYLGRCSFYLSIYLSIYLSIYLSIYLGRCSFYLSIYLSIYLGRCSIYLSIYLSIYLGRCSIIYLSSSICSSIYLSISISVAVSIYLSLSIYLDTSKASQLQQPLPLLTSLSFSPSLLLLSYILPPFSYSQDILLNETYIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AK37</accession>
    <name>A0A812AK37_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_1797</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000051">
        <property type="protein sequence ID" value="CAE1146290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AK37"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
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            <end position="24"/>
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        <location>
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            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1146290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="223" mass="26073" checksum="EF49C360B4836227" modified="2021-09-29" version="1">MISFFLSFFLSFFLSFFLIIFLSFSFHCSFYSTVSFFLSFFLSFLCILKIVYFFRRFIFYFLSLFLSFFSSSFCSLSFFFISFLISFSPVTSYSLFSLRLLLLSCYFIPPLVQCLAFFPAHYVYLDFHSLLSCSQQCSPYCSDDNIRPVGIVTPLTSVLSVLTKYILQSVSNYLSIYPILFLSIYLSIYLSIYRSLHLSIYLSIYLSIYHSLPISIYLSISVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ANQ1</accession>
    <name>A0A812ANQ1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="13">PKD1L1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SPHA_3832</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the polycystin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000115">
        <property type="protein sequence ID" value="CAE1153377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10044145at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005261">
        <property type="term" value="F:monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006816">
        <property type="term" value="P:calcium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.60.20">
        <property type="entry name" value="PLAT/LH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057244">
        <property type="entry name" value="GAIN_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000203">
        <property type="entry name" value="GPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003915">
        <property type="entry name" value="PKD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001024">
        <property type="entry name" value="PLAT/LH2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036392">
        <property type="entry name" value="PLAT/LH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046791">
        <property type="entry name" value="Polycystin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46730:SF1">
        <property type="entry name" value="PLAT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46730">
        <property type="entry name" value="POLYCYSTIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01825">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01477">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20519">
        <property type="entry name" value="Polycystin_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01433">
        <property type="entry name" value="POLYCYSTIN2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00303">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00308">
        <property type="entry name" value="LH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49723">
        <property type="entry name" value="Lipase/lipooxygenase domain (PLAT/LH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50221">
        <property type="entry name" value="GAIN_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50095">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
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            <end position="575"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
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    <feature type="transmembrane region" description="Helical" evidence="10">
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    <feature type="transmembrane region" description="Helical" evidence="10">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
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            <end position="701"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="707"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="732"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="760"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="787"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="813"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="843"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="867"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="892"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="923"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="956"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="984"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1011"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1037"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1066"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1092"/>
            <end position="1117"/>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
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                <person name="Li R."/>
                <person name="Bekaert M."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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            <begin position="243"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        <source>
            <dbReference type="PROSITE" id="PS50253"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAE1150198.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AXJ6</accession>
    <name>A0A812AXJ6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_6927</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
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        <lineage>
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            <taxon>Coleoidea</taxon>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
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                <person name="Bekaert M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
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    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AXJ6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
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        <location>
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        <location>
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        <location>
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    <evidence type="ECO:0000256" key="1">
        <source>
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        <source>
            <dbReference type="EMBL" id="CAE1161536.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="215" mass="25675" checksum="074FFBD8F21D02D7" modified="2021-09-29" version="1">MYNQTATWLLDNTPSIDSNCYLTQSCCKLVVFFLPRCYNFSFHNPNSTNSPSFLTFSLILLLPTRPFDSRFPLLFLSLNFLPLKPDSPTFIFFLISSFFLLSFYFLHSFLFHTKISCNISFFFSHNFRYFYLSIFYAFFLCSLIAFLSFFISFLFALFSFFSILLCFITLKIHFDMIPFIHSFILLFLSNITFLSLFLFLYISFFFLSFFLSFYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AZK3</accession>
    <name>A0A812AZK3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SARNP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SPHA_8087</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Farmed</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAP domain-containing ribonucleoprotein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000262">
        <property type="protein sequence ID" value="CAE1164664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AZK3"/>
    <dbReference type="OrthoDB" id="5837849at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052240">
        <property type="entry name" value="SAP_domain_ribonucleoprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040746">
        <property type="entry name" value="THO1_MOS11_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46551">
        <property type="entry name" value="SAP DOMAIN-CONTAINING RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46551:SF1">
        <property type="entry name" value="SAP DOMAIN-CONTAINING RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18592">
        <property type="entry name" value="Tho1_MOS11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="4">
        <location>
            <begin position="23"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="56"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="259"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="97"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="159"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00046328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAE1164664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="307" mass="33337" checksum="1B1ACAEE875C83B0" modified="2021-09-29" version="1">MADVEANVEEMIAEEDSNPIAGLHKMKVAELRKLLKDRGLPCLGSKPALLARLQKALSPGAAASEEAEAIEEGAEEEDVEEDASDAENVIAEQGIKAQEEVVPEKTDAVLKKTAPPENTENSQEPKEKEDLTNVDSQPVPATEKVTPVVTPPTSETPSIQSTDKSNVVSAKPTLTSDEKLRQRAERFGITSDNDKKAARAARFGTVTTNLSNKPSAKIVSTPVTAEDIDRLKKRAQRFGTVVSSTLSKLEDEDKLRKRKQRFGQITGPTSNPTSTTTTTTTTTTTANKSIEEIEEKKRKRAERFGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B1W8</accession>
    <name>A0A812B1W8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_7780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000252">
        <property type="protein sequence ID" value="CAE1163751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B1W8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="305"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1163751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="382" mass="42959" checksum="FB6CFB7E868E351A" modified="2021-09-29" version="1">MILSLFLSHSFSLSITFPLSFYLISSLFPPHSLSLSLSFPLSFHLIVSLFLYHSLSFSIASLFLYHSVSISISFLLFSITFPLSFYLISSLFPPNSLSLSLSFPLSFPLIASLFLYHSSLSFFIIPSLSTSLSLFLYHSLSLSPHSLFLYHSVSISISFPSFSSHSSFFLLISSLFPPHSLSLSLSFPLSFHLIPLSFYIIPSLFLSHSFSLSISFPLSFYLIPSLSFHLIASLFLYHSFSISISFLLSFYHIPSFSFCLIPFLFLSHLLSLSFYLSPPLSLFLCHSVSFSYYPIHSLFLSNKCVSSSLLLLSLFVYASHDPFLAILFKQMSKAYAKSSPLPRPITWVFSSCLRPLLVLSPSWLPELSQVGDLLSQILLQPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B244</accession>
    <name>A0A812B244_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ADAR</fullName>
            <ecNumber evidence="6">3.5.4.37</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SPHA_8498</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.37" evidence="6"/>
    <dbReference type="EMBL" id="CAHIKZ030000275">
        <property type="protein sequence ID" value="CAE1165536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B244"/>
    <dbReference type="OrthoDB" id="10268011at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003726">
        <property type="term" value="F:double-stranded RNA adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008251">
        <property type="term" value="F:tRNA-specific adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006382">
        <property type="term" value="P:adenosine to inosine editing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19875">
        <property type="entry name" value="DSRM_EIF2AK2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002466">
        <property type="entry name" value="A_deamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10910:SF145">
        <property type="entry name" value="DOUBLE-STRANDED RNA-SPECIFIC ADENOSINE DEAMINASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10910">
        <property type="entry name" value="EUKARYOTE SPECIFIC DSRNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02137">
        <property type="entry name" value="A_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00552">
        <property type="entry name" value="ADEAMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50141">
        <property type="entry name" value="A_DEAMIN_EDITASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="4">
        <location>
            <begin position="115"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="4">
        <location>
            <begin position="218"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="A to I editase" evidence="5">
        <location>
            <begin position="340"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="192"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="202"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAE1165536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="697" mass="78308" checksum="F52F4290ADC3F510" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B4H8</accession>
    <name>A0A812B4H8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_10715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000350">
        <property type="protein sequence ID" value="CAE1169753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B4H8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1169753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="281" mass="32252" checksum="1CE59169F62F5B3C" modified="2021-09-29" version="1">MFNTRGSIPFFNYSVIADIHRSSLRVYMLSCPHPKYGITSKGRFLTPAESQSIFRDSSRVALPDFKASLLSRQNLRNGFVVLDFFFCFSNLALTVDACSFWVVAYHFPPSRRRFPYKLCRLFYYFRSNVRDISFFPALYSSKNSALRAKRTLLCPPGSNELGTHPCRRGANFWALISAVGARTSGHSSLPSGRELISALIFFLISFLIFLCFFSFLPPILHSVYLFITLSFLFLSCSLSSYISFFSLPDTLSYSPTLFFFLSFFLSFFLSFFLSFFLSHYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B6M5</accession>
    <name>A0A812B6M5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_11079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000365">
        <property type="protein sequence ID" value="CAE1170447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B6M5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1170447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="290" mass="33769" checksum="983A68F890C3C8AB" modified="2021-09-29" version="1">MLWSIAKKSYGQSFYLQVPPTHHTLAAAAHSNSQRHPLPTRHAYFILQSDDVVTAASSSEMVGAGAIGTSGHTGFPTPVFQANLSIYLSIYLSIYLSIYLINSYLLYIYIYILRNIRIYLSIYLSIYLSIYLSRHILIYQFQHILIYLSIYLFKHILIYLSIYLSIYLSIYLSQLVHVPIVKSIKEVLILSPSPTFCLPIQLFIIKFVSIYLSIHFLLIYLSIYLSIYLSPLFRSDIYLNLFIFFLSIYLSIYLSIYLSIHFLSIYSFSIYLSIYLSIYLSIYLSFQHIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B751</accession>
    <name>A0A812B751_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_11941</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000400">
        <property type="protein sequence ID" value="CAE1172207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B751"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF5">
        <property type="entry name" value="DYNEIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="308"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1172207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="331" mass="39066" checksum="8546C55CF024A81D" modified="2021-09-29" version="1">METERIEKQHWTLLLRFLFHRYSFFSFSRSFFKPQSSFLLFFLSLFFRPFIPFLTFFLSSHFPCRILDRSILPSHHHSFLTFSLSLSLSLSYFLSFRLSFFHYYNFFGFSCSLFPSSLSFFKPYPSFLPSILPSFLPSFLPSFLPSFHLLLFVFAFLCFVLSFFLFLTVSLFKPHPSILPSFLPSFLPSLYTSIHPSFLTCFLSPFHSFIISFLVLSFTTSIHPSIIPSFLFITLSFSQFVLLSFFIVSFLTDSFVIHAKSTHPLISPSFLPSFLTFFHSFFLSFFLSFFLSFFYLTVGIFFKRLPFFLSFLLFLSFFLSFFQSIHLSFIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B9S9</accession>
    <name>A0A812B9S9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_12887</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000432">
        <property type="protein sequence ID" value="CAE1174034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B9S9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="322"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1174034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="396" mass="46277" checksum="A182A889C6FEE1D8" modified="2021-09-29" version="1">MIVGRLCYASFFQFPLYVSILFLLSTILFSFLFYFSFIFSNFCSLLPSLFLLCPSLFLITFSFPHLLFTLSPLSFSALVFSRLFSSSHFLSFFLSFFFLSFFLSFFLSFFLSFFLSFFSLPCPFLFSSISYFFLRSFFFFYPLSPTPKHFPLLFSSPSLFISLSPFSFLYHSISFSLFISFFLSFFLSFFLSFFLSFFLSFFLSSTTHSLSTCPHSPFSFSVPLPPPLPLSPVFFSFLFSLSTCLPRKSEFEIPSLFIYLSIYLSIYLFQSVHYLSLSLSISVFSLSIYLSIYLSISVCSLSITLSVYFSLLIIYLSIYLSIYLSIYLSIYLFLLIIYLSIYLSIYLSIYLSISVCSYVSKLSFCTLTHCFISYKHTYLYFRVHFLTRLHSRINQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BA23</accession>
    <name>A0A812BA23_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_13484</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000454">
        <property type="protein sequence ID" value="CAE1175187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BA23"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1175187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="177" mass="21160" checksum="1680C9ED9271BDD5" modified="2021-09-29" version="1">MKGWKGWGSRGGFRESADDIFIKSIYFNLPSSQSIYLSIYLSIYLSIYLSLSLSKWKKREEAHNYLSIYLSIYLSIYLSIYYFFFLNVYTYASIYHNLLISIYLSIYLSIYLSIYLIHYIHLFMYRKMHDRLSVYQARHITNLSISECLHICIYLPQSADIYLSIYLSIYLSIYLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BBN4</accession>
    <name>A0A812BBN4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein FAM98A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_15309</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM98 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000533">
        <property type="protein sequence ID" value="CAE1178635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="512356at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:tRNA-splicing ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018797">
        <property type="entry name" value="FAM98"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31353">
        <property type="entry name" value="FAM98"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31353:SF1">
        <property type="entry name" value="PROTEIN FAM98B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10239">
        <property type="entry name" value="DUF2465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="292"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="296"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="314"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1178635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="326" mass="36599" checksum="5993FA9ADA47D130" modified="2021-09-29" version="1">MLQEGPSVAFTQVVSWLSLELQELANLEEHINAVSNLEEISSFLMEVSAFLRELSCPYEALTSGPIEQRLNTRENRVLLLDFLTTELSSVRIISVNKPSPLIIGKEKKKDDDESDVAFFLKQALTVLGLTNIPIDVSPEALFTDLDREIRSLVEKHPDRLGKAALNHSLSEDQWIEVQRINEALSEEYNIRREMLLKRIDVTVQSFMWSKVHTNDILKVYTRSRSCLQTKSNVTIASLLASRDDLLRLQKTSSGHDREVTKCDVNKVLIGAVPDRGGRAWEHDVPREMPQFKKRVAGGGGGHRGGGRGGGGHRGGFHKSGHRNHKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BC40</accession>
    <name>A0A812BC40_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cytochrome oxidase subunit I profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_14629</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000501">
        <property type="protein sequence ID" value="CAE1177422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023616">
        <property type="entry name" value="Cyt_c_oxase-like_su1_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50855">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="239"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="251"/>
            <end position="278"/>
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            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="311"/>
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            <end position="355"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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        <location>
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    <feature type="domain" description="Cytochrome oxidase subunit I profile" evidence="2">
        <location>
            <begin position="1630"/>
            <end position="2181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1177422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="2260" mass="263087" checksum="5C08D6009D54EA43" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BDU0</accession>
    <name>A0A812BDU0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="13">HTR1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SPHA_15612</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000545">
        <property type="protein sequence ID" value="CAE1225105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071880">
        <property type="term" value="P:adenylate cyclase-activating adrenergic receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="7tmA_5-HT1A_invertebrates"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF200">
        <property type="entry name" value="5-HYDROXYTRYPTAMINE RECEPTOR 1B-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
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    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
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    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="220"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="387"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="80"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="259"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="259"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAE1225105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="436" mass="49812" checksum="329089483465A241" modified="2021-09-29" version="1">MDLHNTTLSYGTENVTTFYHIDNTSFLYNNLSYLFVGSDDYDDVSLTTSLTPLGPQFYSIQHAISTSIILGLLILATIIGNVFVIAAVLLEKNLHNVGNYLIISLAVADLMVASLVMPLSALKEISKVWFLQREVCDMWTSFDVLCCTASILHLVAIAMDRYWAVTNIEYIRNRNQKRIIIMIVLVWTVAMFISIPPLFGWRDINYDAEFTGQCVISQDLGYTVFSTVGAFYLPMFIMMFIYLRIYMVARATIRKDNFGKRKDKKPKDNTTVNLLSKPYDSTQNNSNAEMSPKKQHQQIEADVSTLEVKVTNGHVDEAHTVMLPIEPGEAIRQERARNKEKMEIKRERKAARTLAIITGAFIMCWLPFFIIALVGPFFPQAINVPDVLMSIVLWLGYMNSLLNPIIYTIFSPDFRNAFHKILFGKYRRTANRHNVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BFA7</accession>
    <name>A0A812BFA7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_16319</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000571">
        <property type="protein sequence ID" value="CAE1227221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BFA7"/>
    <dbReference type="OrthoDB" id="10055694at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043407">
        <property type="entry name" value="Nkap_D1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46940:SF1">
        <property type="entry name" value="NKAP DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46940">
        <property type="entry name" value="NKAP DOMAIN-CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15692">
        <property type="entry name" value="NKAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1227221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="326" mass="39103" checksum="C66242B5A7DF7960" modified="2021-09-29" version="1">MLQRSAKILLQNELRHTGTHNRMVEEAEMWRQKEKKSLSSSSKKDKDRDKDKEKDKEKEKKNSSSIFFEDTRKSFLYDNRIRDDTVSYGKCRAHMDDEPFPLSTTRSTYWMRQLQKAEEKDPGRWGHSGYKELYPEEFRSDRSEDEENGHHHHHHHHRRKRSSRKRRKEKKRRHHYRSRSDDSRSDSGPRRKRRKSTGCSKHRKHRRSRDLSSGSETVRYIRRKIRKERRRRKHKPRRICDTDIDIKPQLHTSNSPVVGRRHRSTSSSSRRGGGSTRERSSMHDHRQSRHMSTDNTDSGAEEAGSKRQKFQRDYSSSDSEDSYCMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BI36</accession>
    <name>A0A812BI36_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SPHA_17056</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Farmed</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CAHIKZ030000605">
        <property type="protein sequence ID" value="CAE1228986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BI36"/>
    <dbReference type="OrthoDB" id="539158at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895">
        <property type="entry name" value="CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895:SF32">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="191"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="455"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="486"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="571"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="685"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="725"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="1"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="327"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="338"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAE1228986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="752" mass="85965" checksum="9100A7585E4C5BDE" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BJ40</accession>
    <name>A0A812BJ40_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_17662</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000632">
        <property type="protein sequence ID" value="CAE1230388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BJ40"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1230388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="175" mass="19868" checksum="44BC4B181EBE2BAD" modified="2021-09-29" version="1">MAATTGTVPITSGTHSFLYFLSFLLPPLSLSLSLSLSLYLSIYFFIYFQLLSLSLFYSLTLSSFLTRPATFTHYLSRSLISFVSPITFFSLSPPLFLSYSLYLSHFLETQFLLLSLSRYLFLSISPARYHANSLSQSLSPLFFSISLTLVHFSALLSFFLSFLRIFPVSEFKSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BJN1</accession>
    <name>A0A812BJN1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">EIF4G</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SPHA_17867</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Farmed</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic initiation factor 4G family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000640">
        <property type="protein sequence ID" value="CAE1230788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="514777at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11559">
        <property type="entry name" value="W2_eIF4G1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000042">
        <property type="entry name" value="Eukaryotic translation initiation factor 4 gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 4 gamma, 3, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000003">
        <property type="entry name" value="Putative eukaryotic translation initiation factor 4 gamma 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003891">
        <property type="entry name" value="Initiation_fac_eIF4g_MI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003307">
        <property type="entry name" value="W2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253:SF78">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4G1, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02847">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02020">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00515">
        <property type="entry name" value="eIF5C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00544">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51366">
        <property type="entry name" value="MI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51363">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="MI" evidence="8">
        <location>
            <begin position="1018"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="domain" description="W2" evidence="7">
        <location>
            <begin position="1202"/>
            <end position="1371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="433"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="507"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="978"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="106"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="514"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="553"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="569"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="991"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1006"/>
            <end position="1016"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAE1230788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1375" mass="151894" checksum="DBB495FC439425E5" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BKZ7</accession>
    <name>A0A812BKZ7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_18634</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000671">
        <property type="protein sequence ID" value="CAE1232627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BKZ7"/>
    <dbReference type="OrthoDB" id="7485566at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="298"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1232627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="508" mass="58688" checksum="F11A4F26DA554DC6" modified="2021-09-29" version="1">MSFFLCLSLFKKRPFIHVCMYVDVARESSNANIYFSIHSFFFLSFFLSFFPSFFLSFFPSFFLSFFLSLFLVDVLSFLFFISSTYPLFFFFNFLFFLSFFLSFFLSFFLSFVHLFVRSFFLYRQSHVVVYRRLKDESESILARPSSILVLAATPFPLTSSSISHPIPTYIPTSAATFTGSNILTVSPFVISFRISTFSLFIILPLFLSFFFFSFFFVYFSFAFSAWSFFLFFFGFCFVILFIVVLKFLRLNPLLRLLRFAFLFLSFLLFLFFSFFSSFRFFFFFLFTLNFSFFSSLRLLLFSFFFFFFSLLCFTLSSFSFSFLLLLFLFSPFFSSPSLTLFLSLFLPFLTITPFPSSLYHSLSLSLSLFLSLSLYPSLYVSQTLFVLVFDDSKRLRALVNAKLIEGDVSAAVRILASSGTILATTPEVLTALRRKHPAPPSDVRFVQMENNDSNIEISKEAMVAALKSFSGSSSGSVDGLRPGHIKDLISAHTAEAGEHLKKIHNSSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BMQ4</accession>
    <name>A0A812BMQ4_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DAN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SPHA_19526</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000708">
        <property type="protein sequence ID" value="CAE1234797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BMQ4"/>
    <dbReference type="OrthoDB" id="6042322at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004133">
        <property type="entry name" value="DAN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03045">
        <property type="entry name" value="DAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="DAN" evidence="6">
        <location>
            <begin position="60"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAE1234797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="159" mass="17946" checksum="E21F8698CAB04B99" modified="2021-09-29" version="1">MAVFIIGSIYVYAVSVLFPAILAFGPPSAISYTRLSAANNNTKCGVRGLVMNIYPPADHAGRCQPKRIKTFGCKGQCYSYTEVNSNLTRITRSCSCCQPTDFGLQKAVIRCQGGMELRKVGRRIYYAHVKKQKRFSFFCLYHHSLSLSLFWVYSFNYPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BNZ9</accession>
    <name>A0A812BNZ9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_20172</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000740">
        <property type="protein sequence ID" value="CAE1236366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BNZ9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1236366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="303" mass="37451" checksum="12C9135203014687" modified="2021-09-29" version="1">MSFFLPFFLSFFLSFFLSNCHSFCHSFFLFSYFHSFFLSSFLFFLIFLTVILSFFLFFLLSFFMSFFLPFFLSFFLFFLLSFFMSFFLPFFLSFFLFFLLSLFMSFFLPFFLSFLFFFSSYCHSLCHFFSFLFFLSFFLTVILSFFLSFFFFLSFFYVILSTFFFLFFFFLSFFLSNCHSFLSFFSFFFLLSFFLPFFLFSFFIFFLLSFFLFFFFSYCHSLCHSFFLSFFLTVILSFFLLSFFMSFFLSFFLSFFLSYCHSFFFLTVILYVILSFFLSFFLSYCNSFCHSFFLSLFFSYCHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BQB6</accession>
    <name>A0A812BQB6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_20969</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000768">
        <property type="protein sequence ID" value="CAE1237780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BQB6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="13"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="281"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="313"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="341"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1237780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="385" mass="46802" checksum="0540B5FBA0BA473A" modified="2021-09-29" version="1">MIRRYRSFINISFLFYCFFSVSTFTSSQIIFSTYSFLRSSFSSTFFFCSIFLSFFLSSFIHAFSFFLSLLLPSIHSFIHSFFLSFFLSFFFLSFFPCLLPLFIPFFLSFHASSLYSFLPFSFLSFFIYSFLFPPFIPSFFLHSFFPFSFLSFFLSFSFFLSFFLSFFIHSFLFPLFILCFFLFVSFFFFFFFLLSFFLSFFSFFPFPFFFLFFFLFFSFSFILFLSFFFLFFSFFILSFLFIFLSFFIHSFLFLSFFLSFFHSFLFPSFFLYFFRSSFLPFSFFLFSFVSFSSLLSFVLHSFIFLLSSFIPSFFFLSFFLYFLPSFIPSFFSFFLSFYCHRFIFSCFIHHLFVVFFLRKKIGLPLSSDDCYKSLSLANLLMTISF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BTZ0</accession>
    <name>A0A812BTZ0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">EH domain-binding protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SPHA_21723</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000801">
        <property type="protein sequence ID" value="CAE1239206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BTZ0"/>
    <dbReference type="OrthoDB" id="5972258at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050540">
        <property type="entry name" value="F-actin_Monoox_Mical"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23167">
        <property type="entry name" value="CALPONIN HOMOLOGY DOMAIN-CONTAINING PROTEIN DDB_G0272472-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23167:SF46">
        <property type="entry name" value="EPS15 HOMOLOGY DOMAIN CONTAINING PROTEIN-BINDING PROTEIN 1, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="528"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="3">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="493"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="255"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="494"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAE1239206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="554" mass="62101" checksum="CD14E8FFD9A63909" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BW71</accession>
    <name>A0A812BW71_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_23826</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000883">
        <property type="protein sequence ID" value="CAE1243448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BW71"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1243448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="230" mass="27167" checksum="C9797F4BA74DB174" modified="2021-09-29" version="1">MTFRDQITFYQTVKCCKDIYLSHSYLFFSTTLFCLALSSFVFFFFFFVSFFRLLSLFLIFRRSLFLIFFFLFLYCSPFFPYLSHFLSFRSYIFFSFFPFFLFFFTCLFLFFSTCASSFFSLTPPPFFLIFPLLSFLRLQLFLLFFLTFFSSSFSPLPPFLPFSSSSFSPFLFFLLFSLSPLPPSLTFSSSFFSSPLTIPPFFLTISSSSFSHFLLCLPFSLSPLPSFPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BZX7</accession>
    <name>A0A812BZX7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_26815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001025">
        <property type="protein sequence ID" value="CAE1249807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BZX7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1249807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="253" mass="29458" checksum="D98D2EA8C59D1F5B" modified="2021-09-29" version="1">MNYLSIYLSICFCLSLSHFSPFLSHYCYLSIYLSICYTSIVKTTPQHYLSNSAYLSIYLSIYLSIYLSISFCILSIYLSIYLSHSAYYLSIYLFLPTSIYLSIYLSIYLSISFCISIYLSIYLSIYLSIYLSIYLFISFCILSIYLSIYLSIYLYLSIYVAEQAILQVENFVTHNNADLSIYLSIYLSIYLSIYLSILSLRLATSRLSEKDCWVENNLSPTITRIYLSIYLSIYLSIYLSISIFCPLQLSRCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C376</accession>
    <name>A0A812C376_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_27649</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001079">
        <property type="protein sequence ID" value="CAE1251684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C376"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1251684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="166" mass="19467" checksum="2D07B901943CF421" modified="2021-09-29" version="1">MRHKLFHSIYLSIYLSIYLSIYLSIYLSIYLNMLIIYLSIYLSQSVPIYLSISICSYLSIYLSIYLSIYLSMSLHVYLSPLVSYIYLSIYLSIYLSIYLSIYLSVAVCCYLSISILTLRHFSHPVEIGQPAFSHPVQFLYLYISLDKHFYPFPVLSFSFPHFESIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C3W6</accession>
    <name>A0A812C3W6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_26655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001017">
        <property type="protein sequence ID" value="CAE1249523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C3W6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1249523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="295" mass="34598" checksum="549F79576520D41E" modified="2021-09-29" version="1">MVSNVVRVRNDYEFRVFLHPIYQNEAFSSSPFSTTHSFSFFIYCFLSSPFLYYSLFQEGDSSISPSLSLHSFPSEFSILPTYKNNFSRIPLSPSLSELGTFIFSLPQSSLFLPLLYCSPYHFLLLSLLLSFFLSLSLLLSLPFFLFSFPLYCFKMKYPLQEGDSFSKKQLFLFVLPLYCFPYPSLFLYYTLFLFVRPLYCFPYFFSFLYYSLSLFLLPFLLLSLFLPPSQLFTLPLSSLLYFLFLPPPIRLTIPLSPYLSTAFSPKNLFYCWYLPSKRVIFPLRPLVLFTPFLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C6F2</accession>
    <name>A0A812C6F2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_29290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001164">
        <property type="protein sequence ID" value="CAE1254973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C6F2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1254973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="217" mass="25246" checksum="C72E1DB381CD3236" modified="2021-09-29" version="1">MGAGEQAVTIYLSIYLSIYLSIYLSLFIIYLSQSICFSLSLFLFSLSLSLSLSLYIYIYIYIYIYIYISLSIRFFLSIYVYSFLSIYLSIYLSKSIRFYLSTYLSQAICFYLSIPDVLVYSYLSIYLSIYLSIYLSIYLSIPFCSHLCAFLFVSINVPVYESLSFFFDSHTLIIPPSHCENHHIFVVQSMFIDESKPAEGGAERNPIHTRMPAAFYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C6T3</accession>
    <name>A0A812C6T3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_29341</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001168">
        <property type="protein sequence ID" value="CAE1255110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C6T3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032946063" evidence="2">
        <location>
            <begin position="16"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="287"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1255110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="321" mass="35310" checksum="14364FCB6A3DA3D5" modified="2021-09-29" version="1">MRFCIIFFFRHFSFSIKLISFLIFPREFLDFLSRCYNLFSSICITTSPFSSSPSSFFLSLSRSLISSLFLSLFLINSLIHFSTFSPLSLLSISLNLSLSSQSLSISQSLSISLSLSSQSLSISLSPLNLSLLSISLSLSSFSLSPLNLSLSSQSLSLLSISLSPLNLSLSSQSLSLLSISLSLSPLNLSLSNISISLSLSLVIYLSLSLSSQSLSLSIFTIYEKENGGKNSLSIKNLTFSISSLSRDTPIISLSFIASFFFFSIVSLSFFLVFSLLAFSISLSSQSLFFSCFSLNFALFSLSPFFFLFLLLFFFSQNPYNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C712</accession>
    <name>A0A812C712_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Protein transport protein SEC23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">SPHA_30724</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">Farmed</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Cytoplasmic vesicle</location>
            <location evidence="14">COPII-coated vesicle membrane</location>
            <topology evidence="14">Peripheral membrane protein</topology>
            <orientation evidence="14">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Endoplasmic reticulum membrane</location>
            <topology evidence="14">Peripheral membrane protein</topology>
            <orientation evidence="14">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the SEC23/SEC24 family. SEC23 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001238">
        <property type="protein sequence ID" value="CAE1257354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C712"/>
    <dbReference type="SMR" id="A0A812C712"/>
    <dbReference type="OrthoDB" id="10256289at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01478">
        <property type="entry name" value="Sec23-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11287">
        <property type="entry name" value="Sec23_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.730:FF:000001">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.380:FF:000001">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1670:FF:000006">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000003">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000011">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037364">
        <property type="entry name" value="Sec23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037550">
        <property type="entry name" value="Sec23_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11141">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11141:SF0">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13 14" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 14" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0813">Transport</keyword>
    <keyword evidence="8 14" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="16">
        <location>
            <begin position="67"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="17">
        <location>
            <begin position="136"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="19">
        <location>
            <begin position="415"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="18">
        <location>
            <begin position="532"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="15">
        <location>
            <begin position="646"/>
            <end position="732"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU365030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CAE1257354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="784" mass="88558" checksum="B73ED7D66893F2B4" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C7X0</accession>
    <name>A0A812C7X0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_31140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001268">
        <property type="protein sequence ID" value="CAE1258252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C7X0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="165"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1258252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="257" mass="28272" checksum="F71BD42AA92B11B4" modified="2021-09-29" version="1">MSPSNTLQVKSGPSFSKWYTCAFLLPVCSLPSSRFLDNRDVGVGVFRSVWSFFLLRGVLTRFIPRLRSRTPSLVPELATSRTVRPQRPWVASIVCRTVRHSVFCFFFFLLLLPCLFLLMSLLDQYSPKTRVLFGLTCSRLDKTNANFSPLSDGRGNSHGSILVNTTPASSVPSQSSSVPSQTSPPSTPLHKTSPTKKTTPSTSSAQTHSSKPSTPLSRDPALSNKSLHLATLPVLPPLNHMKCPLLLSKYKGVQPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C8K5</accession>
    <name>A0A812C8K5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_34676</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001478">
        <property type="protein sequence ID" value="CAE1265443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C8K5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="317"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="345"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="375"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="400"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="439"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="479"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="511"/>
            <end position="540"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="547"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="577"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="613"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="640"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="672"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="700"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="745"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="772"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="797"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="827"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="884"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="944"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="973"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1011"/>
            <end position="1037"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1265443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1132" mass="134297" checksum="97B79D9EFA9A5FDC" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CA37</accession>
    <name>A0A812CA37_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_32996</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001378">
        <property type="protein sequence ID" value="CAE1261981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CA37"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1261981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="220" mass="26135" checksum="7302E593266E7E98" modified="2021-09-29" version="1">MYFLSFFFHFSHWNYLSQICSDINIYIYLSIYLSIHIISIYLSIHPDLLNKPFYFLVLSSSIHLSILSIYLSIYLSSIHLSHLFISSIIHPSIYLSIYLSIPKSIHSIYQSNYLSIYLSIYPLFIHLSIYLSIYLIYYLSIYLSIYLSIYLSGENSSPVHYLSIYLFIYLSIYLFIYLQSLFINLHLTIYLSIYLSIYLLSIYLSSYYLSIYLSIYDPSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CAS6</accession>
    <name>A0A812CAS6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_30891</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001247">
        <property type="protein sequence ID" value="CAE1257639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CAS6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
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    <proteinExistence type="predicted"/>
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            <end position="36"/>
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        <location>
            <begin position="48"/>
            <end position="69"/>
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    </feature>
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            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
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        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1257639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="260" mass="30561" checksum="55197E6E11CC832B" modified="2021-09-29" version="1">MFCFCFFRYFYIYLFIYPPPSSLSLSFSFSIFPFLFRFITLTIHPSLSLSFFLSFPFLLAFSLSIYLFFSLLICHSKYVTFSFFLSILLSIILFVSLSTLSRFLSIYLSIYLSIYLSIYLSLSVRIYLSTNLSIYRCLFVFIYPPIYLYISFPPSPSLPIYLSIYLSIYLSIYLSIYLSIYVFLLFNFFLSTFISYYFFPSFFLPSFLTFFSSVSLYLFVYIYSSFSLSLSLSLHLPHFSLSLSLSLSVCVCMCIFPSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CD02</accession>
    <name>A0A812CD02_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_37061</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001640">
        <property type="protein sequence ID" value="CAE1270990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CD02"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="279"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="338"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1270990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="421" mass="49728" checksum="05DDA2AD2A9FCF81" modified="2021-09-29" version="1">MTSLNRREVKLCREFSLSLSVCGNDPLTRCWCSLFTCFQLRFWRKSIYGLYYLSMLILKWSLSLSLSIYLSIYLSIYLSIPTLFLSIYLILRGNTGVHIFHYITIYLSIYLSIYLSIYLSIYLSQSVLYLSVSVCSFSVYLSHLKDKQFERLYVSIYICLFCSIYLSIYLSIYLSIYHIYLFYSYLSIYLSIYPIFLVPATGIIDLSIYLSIYLSIYLSIYLSKYFPTRLRSIYLSIYLSIYLSVSSFIPVHVCLSVYLSIYLSICQLVHPLHLLRSLYFRPFMFIYLSIYLSIYLSIYLSTLSLDKTPESVSIYVSLSAFSYLSIYLSIYLTSFISLFLFIYFNSFMFIYLSIYLSYMSRRNLVFIDISLFMCLNCKFSDNLSIYLSAEGDRKREIVQYKDILRQKKSIENSLECFVSVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CI30</accession>
    <name>A0A812CI30_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SPHA_39592</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001852">
        <property type="protein sequence ID" value="CAE1275667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CI30"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="190"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="220"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="263"/>
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            <end position="325"/>
        </location>
    </feature>
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        <location>
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            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="360"/>
            <end position="384"/>
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        <location>
            <begin position="396"/>
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        <location>
            <begin position="421"/>
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        <location>
            <begin position="450"/>
            <end position="475"/>
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        <location>
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        <location>
            <begin position="517"/>
            <end position="543"/>
        </location>
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        <location>
            <begin position="549"/>
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        <location>
            <begin position="582"/>
            <end position="606"/>
        </location>
    </feature>
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        <location>
            <begin position="612"/>
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        <location>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="733"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="307"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAE1275667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="758" mass="88819" checksum="48AA589A763249B0" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CLK5</accession>
    <name>A0A812CLK5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_41273</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001979">
        <property type="protein sequence ID" value="CAE1278487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CLK5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
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            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1278487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="258" mass="31310" checksum="4C0F83658A19B4EA" modified="2021-09-29" version="1">MKTFPPVYFFMLHAQIFPVLFRLFFLFSLTLLFAYFFFLFSSLTVFSLFSFLSSFSSLLTFSFLLPLLCSSLSRPDFDFFSSFSFLLISLSLFLSFLYLFFFFLLVTILLFLYCIFLFIWISFQILFSSFFFHFFLNYSVFLVHLFLFFLQLFLFFPCLYSLFLDFFSLFCILFSFNRIFFSLSASFFSIVRIIFYFFSIFSTFLHHFRFFLHLFHFLLPRFRFILHCFPFFLHLFLVFCVVVLRPFLGLGSVVAWVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CN53</accession>
    <name>A0A812CN53_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_37591</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
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    </organism>
    <reference evidence="2" key="1">
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            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001676">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000597762">
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    </dbReference>
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        </location>
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    </feature>
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        </location>
    </feature>
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            <begin position="242"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1272217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="272" mass="31947" checksum="5DC18D49F512E8A2" modified="2021-09-29" version="1">MKWSLIYSLRDAMCPQTRGHSITDTFDSEDEPISHFISIYLSIYLSIYLSVCLSVYLSIYHNSFLSISDCTLSIYLSIYLSILFNLYLSHSILIYLSHSIHIYPLSIYLSIYLSIYIYLSTVLSIYLSIYLSIYPSIYLSIYLSVFIIYLSIYLSIHIYLSQCVCYLSIYLSIYLFNLCSIYLSIYLSIYLSIYLSVSNFYLSFLFLKSKSIYLSIYVCSLSIIYLSIYLSIYLNYIVLLSIYLSIYLFYLSQCSIDLSIYLSIYLSRIYNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CPA6</accession>
    <name>A0A812CPA6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_41077</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001965">
        <property type="protein sequence ID" value="CAE1278151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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            <end position="31"/>
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    </feature>
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        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
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        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
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        <location>
            <begin position="137"/>
            <end position="162"/>
        </location>
    </feature>
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        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1278151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="231" mass="27551" checksum="E6F12700E3050F24" modified="2021-09-29" version="1">MNDSNDSFIYLSIYLSIYLSISINFDILLYLRNLHFRIYLCFILIYLSIYLSRIYPYLFHHYLSQFDHYLCFTIIYFSLIITYLSTFCDPKGGNHNNIYILPLSIYLSIYLSIYLMPEHYLAIYLQAQTFQSVHICLSIYLSIYLSISVCSYLSIYLSIYLSIYLFHLSQKLNFIYLSIYLSISICSSIYLSIYLSIYMSYLSIYLLSLFISIIYLFNIYLCSYLSIYLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CPX2</accession>
    <name>A0A812CPX2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_37882</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001705">
        <property type="protein sequence ID" value="CAE1272909.1"/>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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            <begin position="6"/>
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        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="302"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1272909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="328" mass="41775" checksum="C439AEC9FB468750" modified="2021-09-29" version="1">MFFTFFHYFFFLSFFLSFFLSFFLSFFPNTPSLFLSFFENVFFFNFLSLFSFFFSFFLSFFFFSFFLFFFFSFFLFFICFFNFFLIFCFFFLFDSFFLSFSFFLFFFLSFFFLFFQAFFFFFFPYFLLFFHYAFFFLFFSFLSFFLFLFFLSFFLYTQASFFLSLIPCFFSFYYFLFFLSFFLSFFLSFFSFFSFFNTPFSFFLFLILFFYWRKLCSLLSFSDIFFFFSFFFVLSFKFFSFFLFFSFLSLSFFSFFLSFFFSFFLFSFFFLRFSFLSLFFLSFFSLLSFFLSFFLFPFLFSFFLQLCSFFLFFHFFLSFLSFFFFFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CQ29</accession>
    <name>A0A812CQ29_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_41455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001990">
        <property type="protein sequence ID" value="CAE1278779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CQ29"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1278779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="225" mass="26915" checksum="3381646062F6F9E4" modified="2021-09-29" version="1">MHTYICSRSCLSIYLSIYLLKYVCVNLSIYLSIYLSIYLSIYLSIYIYRHQYDEYRITKCDKQVIRRNNLFNVDLSIYLSIYLSIYLSIYLSIYLSTQLARDRALNVDIELIKCFYLSIYLSIYLSIYLSIYLSLLYLSIFVHIYLSIYLSIFMSFYFCSYLSIYLYHSISLYSVHIYLSILCSYLSIYLSIYLSLSLPIYLSIYLSIYLSIYLILFISIYADNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CQB5</accession>
    <name>A0A812CQB5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_38029</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001719">
        <property type="protein sequence ID" value="CAE1273234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CQB5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1273234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="235" mass="29632" checksum="ADFC2788F87BD2B4" modified="2021-09-29" version="1">MKIFLLFFSSIHIFLLLLEKFLFFEVFCPFSDSFLFLLKFFFFFFFFFLEFFFFFFFFSVTFSSSFSIFFFFILLLFFSSVCSFFLLLFFFFLFFSSSSSFSFKNVFIFLLFFIFFLHFFLLFFFFLFFLKNLFFFFFLLLFFLYFLFHFFQYIFLLSFGREFFFFFIISSLNYLFPLLLQKFLFQTLLKLFESFFNIFFLLLLYKSFIFFFSSSSFLLRLCLLLFFFFCLFFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CR56</accession>
    <name>A0A812CR56_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_39504</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001838">
        <property type="protein sequence ID" value="CAE1275517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CR56"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1275517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="249" mass="28105" checksum="BA7299C537CE1546" modified="2021-09-29" version="1">MNAVHKFVLFLYIPVIYFFIYLSIYLFACSLSIICLSHPVHIYLSISLSVFISIYLPISLCSYLSVCRSFSQPVLIYLSISVCSYLPTYLTVFISVCLSVFLSACSYLSISVCSYLSTYLSHCVHICLSVSFSQPVHIYLSQCVHIYLPTYLTVFISVCLSLSLSLFISIYLSVFISIYLPISLCSYLSVCLSVSLSLFLSACLYLSIYLCISAYLSISLSLFIFIYLFISASLYLSQPVHIYICCVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CRA0</accession>
    <name>A0A812CRA0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_39585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001851">
        <property type="protein sequence ID" value="CAE1275649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CRA0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1275649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="332" mass="39260" checksum="405C09181DD9CE66" modified="2021-09-29" version="1">MWQRVFLPFDEYHTKKIERDNAFSHFPRSSPPLFSLSFFLSLSLSLSLRRFQIIIFQLKELRPFVHLRNIKICYVCLIDLSIYLSIYLSIYLSIYLALNIRVQSLAFTQTCSSIAGHKNYILFFVSLYLPTYLSIYLSIYLVYISIFVLWERFSYLLFFSLSFIFSLFSLSHSLFLYLSIYLSYSYLFPLLRLCIIFSSVPKVYLKTIFLSYILYIYITFIQISKLSLSLTHSLTIYLSIYLSIYLSIYLSLSLSLSLSVRDYTFLPSPSPYCFLFPLCIPLPSPPFLISSFVRFILASLFPQPRFLSLIYLSIYLSIYLSIYLSIYQFVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CWP5</accession>
    <name>A0A812CWP5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_44667</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002282">
        <property type="protein sequence ID" value="CAE1284291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CWP5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="308"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1284291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="325" mass="37733" checksum="7273B77FBEC746A7" modified="2021-09-29" version="1">MKPSFLSFFLSFFLSFFLSSLSFFHTDKHYLSIYLSIYLSIYLSQLFIIYLSIYLSIYLSIYLSIYLSLFNIYLYLSIDCSLSIYLSIYLSIYLSIYLSIYLSPASHTQIYIHFCVISVTIYPSHILSIYLSIYLSIYLSILFISMYVCMYVSIYLSIYLSIYLLQTNIIESIDQGYYLDFAYSNFCQYDCFNLLPRKKKTFYSYFLTDHCTSSIFTILLLIIILTSHGHVPSKLHSNKTPVQTLSCTFPSKNTPTTQVTMFNTSHTEHSHIANSSSSSSSSSFSFFLLLLSTFSFFFLLYFSSSSSFFSSSFFFFFLLLSSSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CWR5</accession>
    <name>A0A812CWR5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_43051</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002135">
        <property type="protein sequence ID" value="CAE1281801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CWR5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1281801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="212" mass="25064" checksum="B63C5818426D1779" modified="2021-09-29" version="1">MKLSIYLSIYLSIYLSIYLSIYLSIYVGGGARERRKMFYFDIRTNTLSVVPYECVCKYKHDYHDYDDVAKSLFFSLSLSSFFQNVFLYTPPICIYLFVLSLLLSLVRNLIFSFCLSPHLSIYLSIYLSIYLSIYLSIYLSIYLNLTLYLQNLAYSYKMHFTFFLSFFLSFFLSFFLVLSPPLYMTQTNDNGASRIHTTHRRCKTSFPNTIFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CXF1</accession>
    <name>A0A812CXF1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_45000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002316">
        <property type="protein sequence ID" value="CAE1284876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CXF1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1284876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="160" mass="16943" checksum="2AFBF8084F6C1BC7" modified="2021-09-29" version="1">MLIRRRLVLLPFWKVIPSSSDSSSLPLFKDKHRGGTISSALYQILTAPDFSTVVASAALDTIEAAALVVDFAEVTLHFVVVAIPPWAAAPAVAASVDVAATSRPVRHPAGPAGQDRLQPFASFSQPPRPITSDSFSDLLFLTVSVIPTAIVTQVSPKDTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CYG6</accession>
    <name>A0A812CYG6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_46964</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002516">
        <property type="protein sequence ID" value="CAE1288174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CYG6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1288174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="357" mass="41803" checksum="54B90CC9DA93BC09" modified="2021-09-29" version="1">MQTPTPHSIKYLSSCPDNLNPKVYQKLSCSLVHYLSIYLSIYLSQSFSYLSIYLSIYLSNSVHIYLSIYLSIYLSIYLILFISTAVCYLPISVWSLSIYLSIYLSYSVLFIYLSIYLSIYLSIYLFYSVLFVSIYLSIYLSQSTSYLSTYNTLFLSLYLQIKQVCGGILSIHLSIFHFSTIYLSIYLLISKSISHQMHLTIYLSIYLSFLTTYVFFHSENRHISLSLSSPVSWLFFFFFFFEQILLHMTIFFFFVFVSATSGKKKWGSTFSLNYCNLLFLMPYTTFFFYLFFPFSSLKVFSFFFLSLAVFPLASFLFLLPSFYVFLLFPTFSFIVLFSSLIFSLSKTFSHCSFPFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CZR8</accession>
    <name>A0A812CZR8_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">X-box-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SPHA_46768</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002490">
        <property type="protein sequence ID" value="CAE1287721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CZR8"/>
    <dbReference type="OrthoDB" id="20960at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14691">
        <property type="entry name" value="bZIP_XBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052470">
        <property type="entry name" value="ER_Stress-Reg_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46542">
        <property type="entry name" value="X-BOX BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46542:SF1">
        <property type="entry name" value="X-BOX BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="BZIP" evidence="9">
        <location>
            <begin position="124"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="38"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="227"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="288"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="375"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="142"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="40"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="95"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="288"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="301"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="410"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAE1287721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="460" mass="50306" checksum="59CFE65A011A690B" modified="2021-09-29" version="1">MVKTLAVANSPTKVPTTANVIKTTVSSPVHRFLSPKQSVTLSSTNNTNATSSLQQKNYSSSSTTVTTPSTLSSSSWTTLLGQNSNGYSDSDDSINDQNSSSASSNNSNCGEPKKRRRLTHLTPEEKILRRKLKNRVAAQTARDRKKAQMNDMEETIANLQAENKRLMQYNSTLQKKAYELATENAELQHRLAEETGSDSVSFDNAINQLPESGDLFTLLDEVYGSDTGASLDNCTTPSTTTESSEREEKNAACPAQSPHPVVGASPTQLDSLNELIKSEHFYVKYAPSSAEDSSSSSGCSSDEDEVSPNEEVQESSPSAMPVKEEFLSLTDDCFSFAENMMLFENLMKECLSNDEGMTTSEELPDSVLMKNDESCDMPAQESETTSLIPTNRKRTSEDENVEIVNKLPKTGSITDSGSDSGIHSDYSNPSSPYQEQSLLQFNDMNPVDDILFPELFPCLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D059</accession>
    <name>A0A812D059_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_45112</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002323">
        <property type="protein sequence ID" value="CAE1284975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D059"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1284975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="177" mass="19843" checksum="16F6FDE40867A0E8" modified="2021-09-29" version="1">MSHCCKTRGCFLSLLSLNTFPSFIYIFMITAMSLIKYFLSIHGLKSTNTSRCLFSLTNTFSHPDTHTLSLTYFLSLSLALTFSLSLLHLLSLSLSCTYFLSLSLALTFSLSLLHLLSLSLSFSLSHKKFSSHSRSAVYGTFSSSSSIPSFIDPLPRFTPSPSVFPDCCCLYNWWCYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D0Z8</accession>
    <name>A0A812D0Z8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_47376</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002557">
        <property type="protein sequence ID" value="CAE1288897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D0Z8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1288897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="165" mass="19653" checksum="4ECE5B9990958560" modified="2021-09-29" version="1">MFILQRYSVTVSHNSPMHICHEPSHIAYSPFDNYRIETLELFYIYLPIYLSIYLSIYLSIYLSISLLSIYLRQKISLSLYLSIYLSIYLSIYLRMDQPIYLNHLMLSNLLSLTMLKCLYMFYPSIRISSHDSFAYLSIYLSIYLSIYLSPYIYIYNRIADACNLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D2S8</accession>
    <name>A0A812D2S8_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7041 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_47714</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002611">
        <property type="protein sequence ID" value="CAE1289558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D2S8"/>
    <dbReference type="OrthoDB" id="6159822at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055469">
        <property type="entry name" value="DUF7041"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327">
        <property type="entry name" value="ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327:SF3">
        <property type="entry name" value="RNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23055">
        <property type="entry name" value="DUF7041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7041" evidence="1">
        <location>
            <begin position="9"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1289558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="258" mass="29283" checksum="AECC7B5F3E930587" modified="2021-09-29" version="1">MTAAVTPFPPFHEGNIKNWFLQMEAIFTVGRITDQKTKFGHVVAVLPPAIVDEVSDFIEAVPEVEPYARLKEAILRRMGRTEESLIRELFSNLTCDGRTPSQLLRYMKSRLGKNTMADSILKSLWLDRLPTTITQILAPMSENTPIDQLADAADRIFSQLDHKTTPVHSAEAISDHRSLGKTVEDLQRQVRDLTLALESHGRSRFPSRRRFRSRPRSSSRNKDATSMCYYHRRFGSAAHYCTKPCTYTAVAENKTASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D482</accession>
    <name>A0A812D482_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_46337</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002445">
        <property type="protein sequence ID" value="CAE1286997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D482"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1286997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="196" mass="22218" checksum="B44145DEC7F5F6BC" modified="2021-09-29" version="1">MSFKSEFFSSSSSSPFSLFLSFFLSFFLSFFLSSSSSLLFPPLPSSYFFFFSSSPFSFFLSFFLSFLFFSFLFLSFFFFSPFSFFLSFFSSSSSSSSFFLFFLFILSSFFFFSSSPFSFFLSFLFFLSSSSSSSSSSSSSFLSFFLSFFFSFFLSFFLSFFLSSSSSSSSSPSRHPFAQAHQVSLISLAPNMPHGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D6M8</accession>
    <name>A0A812D6M8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_50848</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003024">
        <property type="protein sequence ID" value="CAE1295297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D6M8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134:SF22">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134">
        <property type="entry name" value="OS08G0543275 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1295297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="340" mass="39978" checksum="323EA572F39D4F3C" modified="2021-09-29" version="1">MYIGICNSHVWCVNLNIYLLGISTRFLARPRNLPHSIYLSIYLSIYLSIYLSIYLSVCLFISSIYLSIYLSIYLSIYLFISVYLSIYLSIYLSQSVHIYLSIYLSIYLSLYLSIYLSISSVHYLSIYLSIYLSIYLSISSFISVCSIYLSIYLSISSVHFLCHCLISYLFIYLFLSFFLSFFLSSFFLIFIIYLSIYLSIFYLSIYLSIFILSMYLCMYVCMYVCMYVCMYVSIYHLSIYLYTYLFIYLSISVTSLFIYPSIYRDLIPYFPPSLSLSLPSFLPSFLRLFSPFFLNSHRQTYVELKPRKCLSKHSECHASVSGRHSYLLIVTHPTAPHPRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D8J2</accession>
    <name>A0A812D8J2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_51373</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003108">
        <property type="protein sequence ID" value="CAE1296266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D8J2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1296266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="207" mass="24324" checksum="3D459F0186958C64" modified="2021-09-29" version="1">MFHTDQDDADQKVVHFFRKVTSVVHCFLILAFHIICPFCFFFFPCYSFLRTPLSLSLSLLSFILSSFIFCFLLLFFISISFPHSPIFDFSFLSKPLSLSLFLLSSSLFSQFFFFLFLQIYLSFPLSSFLLTRSLFLSFWLSSFSKSHFISLYHSLLSPLSLFFYVFLQIIFFTSHPFSVPFFSHLLLSLDFTNIYIYMLDTPVVSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D8X2</accession>
    <name>A0A812D8X2_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Integrin beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">SPHA_48232</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 18">Cell membrane</location>
            <topology evidence="1 18">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 18">Belongs to the integrin beta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002666">
        <property type="protein sequence ID" value="CAE1290483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D8X2"/>
    <dbReference type="OrthoDB" id="410592at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008305">
        <property type="term" value="C:integrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033627">
        <property type="term" value="P:cell adhesion mediated by integrin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000036">
        <property type="entry name" value="Integrin beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000002">
        <property type="entry name" value="Integrin beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.100">
        <property type="entry name" value="Cytochrome c1, transmembrane anchor, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1680.10">
        <property type="entry name" value="ligand-binding face of the semaphorins, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1510">
        <property type="entry name" value="ntegrin, alpha v. Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040622">
        <property type="entry name" value="EGF_integrin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057073">
        <property type="entry name" value="EGF_integrin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033760">
        <property type="entry name" value="Integrin_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015812">
        <property type="entry name" value="Integrin_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014836">
        <property type="entry name" value="Integrin_bsu_cyt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012896">
        <property type="entry name" value="Integrin_bsu_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002369">
        <property type="entry name" value="Integrin_bsu_VWA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032695">
        <property type="entry name" value="Integrin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057243">
        <property type="entry name" value="Integrin_I-EGF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10082">
        <property type="entry name" value="INTEGRIN BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10082:SF60">
        <property type="entry name" value="INTEGRIN BETA-PS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23105">
        <property type="entry name" value="EGF_integrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18372">
        <property type="entry name" value="I-EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08725">
        <property type="entry name" value="Integrin_b_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00362">
        <property type="entry name" value="Integrin_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17205">
        <property type="entry name" value="PSI_integrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002512">
        <property type="entry name" value="Integrin_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01186">
        <property type="entry name" value="INTEGRINB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00187">
        <property type="entry name" value="INB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01241">
        <property type="entry name" value="Integrin_b_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01242">
        <property type="entry name" value="Integrin_B_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69179">
        <property type="entry name" value="Integrin domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103575">
        <property type="entry name" value="Plexin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00243">
        <property type="entry name" value="I_EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="11 18" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15 17" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13 18" id="KW-0401">Integrin</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="5 18 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="660"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="20">
        <location>
            <begin position="111"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="21"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="166"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="219"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="389"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="419"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="442"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="447"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="471"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="473"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="478"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="495"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="516"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="518"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="523"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="534"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="555"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="557"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="562"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="582"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="588"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR002512-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU000633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CAE1290483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="735" mass="82828" checksum="CB761927ACA5F024" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D9C8</accession>
    <name>A0A812D9C8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_51815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003164">
        <property type="protein sequence ID" value="CAE1297020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D9C8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="297"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="330"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="369"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="394"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="426"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="460"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1297020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="527" mass="61832" checksum="419E5D6452BE9FDC" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D9I3</accession>
    <name>A0A812D9I3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RINT1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_48300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RINT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002674">
        <property type="protein sequence ID" value="CAE1290624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D9I3"/>
    <dbReference type="OrthoDB" id="2189254at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070939">
        <property type="term" value="C:Dsl1/NZR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060628">
        <property type="term" value="P:regulation of ER to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.670:FF:000003">
        <property type="entry name" value="RAD50-interacting protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1420">
        <property type="entry name" value="Dsl1p vesicle tethering complex, Tip20p subunit, domain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.670">
        <property type="entry name" value="Dsl1p vesicle tethering complex, Tip20p subunit, domain D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042044">
        <property type="entry name" value="EXOC6PINT-1/Sec15/Tip20_C_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007528">
        <property type="entry name" value="RINT1_Tip20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042042">
        <property type="entry name" value="Tip20p_domB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13520:SF0">
        <property type="entry name" value="RAD50-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13520">
        <property type="entry name" value="RAD50-INTERACTING PROTEIN 1 RINT-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04437">
        <property type="entry name" value="RINT1_TIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51386">
        <property type="entry name" value="RINT1_TIP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00061158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1290624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="796" mass="92233" checksum="18CB090D8804EF34" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D9U5</accession>
    <name>A0A812D9U5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_50213</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002933">
        <property type="protein sequence ID" value="CAE1294033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D9U5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="356"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="390"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="419"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="442"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="470"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="498"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="531"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="562"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="596"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1294033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="630" mass="76026" checksum="169933610E967DA5" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DCF3</accession>
    <name>A0A812DCF3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_49786</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002888">
        <property type="protein sequence ID" value="CAE1293399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DCF3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1293399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="228" mass="26749" checksum="774BAEDCB29D0098" modified="2021-09-29" version="1">MIGPPHFLLLHYYHHWLSSLSSHSVSSFTHSTGITLYINLLFLLPTFFIFYQHHHYHHYSFLSHIFSHSLTLSLSLSLSFTHFISITITPFLSPSLSLYCFHLFLQCLYFSSLFTLLFSFPSQLNCHKSLTLSNPLFFSLFLFHIYLSIYLSIYLSIYLSIYLSICLNACICFISIYLSIYLSIYLSIYLSMFMLTFVLSIYLSIYLSIYVFFFLFFPILPLSLSLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DDV5</accession>
    <name>A0A812DDV5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SPHA_51023</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003054">
        <property type="protein sequence ID" value="CAE1295645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DDV5"/>
    <dbReference type="OrthoDB" id="28045at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035023">
        <property type="term" value="P:regulation of Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13329">
        <property type="entry name" value="PH_RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041020">
        <property type="entry name" value="PH_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051632">
        <property type="entry name" value="Rho_GEF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13944">
        <property type="entry name" value="AGAP007712-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13944:SF21">
        <property type="entry name" value="CYSTS, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17838">
        <property type="entry name" value="PH_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="568"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="610"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="695"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="722"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="747"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="777"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="812"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="869"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="10">
        <location>
            <begin position="87"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="9">
        <location>
            <begin position="317"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="492"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="256"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAE1295645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="892" mass="103831" checksum="27F8537E00F18A3E" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DFV3</accession>
    <name>A0A812DFV3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_52729</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003317">
        <property type="protein sequence ID" value="CAE1298713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DFV3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1298713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="341" mass="36909" checksum="BC239F7BA8144394" modified="2021-09-29" version="1">MGDSVAALWSSNPNLGGGRFMRYAAQARERANARRRKRDRAARLLAFNTRWQPLLDTASSRGLAWLVMSFLSGCCLMIIWVRSAKQGSARPRRNTGRVCPPGALLVLALAALGAMFTGGAPMAASLHNGPAGVFRDPRRFLRRSGYGARNPCFVVGGLGGSILLAIGIALPVSVAAGLPFSTRVRSSFWSEGYAKPAGLLMLWVSTATLLFLVLAINLDSVLRLQFGGASHLRSRWRSGRADDPMLLTATGLGTGARFLGSAQPRHARLHHRSLAPHGGLAASDMRLGRRFSLIRVNTQPADHRLWITHGKPVATDPHPVIMVAFFAPTFCHSSMGERRRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DKE6</accession>
    <name>A0A812DKE6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_55307</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003667">
        <property type="protein sequence ID" value="CAE1302917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DKE6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1302917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="341" mass="39726" checksum="88BB3707DF99B81F" modified="2021-09-29" version="1">MFHLSPFFTTLQYSRSPDPCPSRPYLYRRGPASHHLYAESFAPPQPIVPSPNRTSPYNSPAKALMRDQHELFPVFIRRSLKARWSIFSFGAGGVGVGTWLSRFSSSYQSRFLYFSFYLSIYLSIYLSIYQPVYIYLYIYLSKPVYIYLAVHIYLSIYLSIYLSIYLSISICLHLSIYLSIYLSIYLSIYLNLFTSIYLAVHIYLTIYLSIYLSIYFNMFTSIYLSIYLSIYLSIYLNLFTSIYLAVHIYLSIYLSIYLSISTCLYLSIYVSLFLSLSLSLYLSIYLSITVASLSIYLSIFLSITVTSYLSIYLSIYLSIYLSIYLSIYLSLSLLYLSIYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DKL2</accession>
    <name>A0A812DKL2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_54842</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003613">
        <property type="protein sequence ID" value="CAE1302199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DKL2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1302199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="247" mass="29617" checksum="9260CDA8576DBB8E" modified="2021-09-29" version="1">MSCKKISHSRLSLFLSLSLSLFCLSVRSLTFSFSSCFVILVSLASHSLLFPLFLQPHSDSILSPLVFFYKPFISPLLSSVSLSCSSLFLPPILSASLDFSLSPHSFFLFSLFLLSFYHLIPFTFSFLFFSFTEFFLSFSLFFSFLRSFSQFFFFFSFFPFSFILFFLFLSLLFLAYHLMSFYFFIFFFLSFLLNSLFKFSLFLSFHFSFFLSSFFFLSFYFFFFFFFSFFFLFLFFFLSFFLFFFQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DM89</accession>
    <name>A0A812DM89_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_55514</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003702">
        <property type="protein sequence ID" value="CAE1303296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DM89"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1303296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="282" mass="32338" checksum="98846471664643F5" modified="2021-09-29" version="1">MFLLSLMFHFSPLLFVYSILLSFFLCFRLFAYLLHSLSLSLSLSLSLSLSLSLNYLARNAFQSLRQNISITIEGISVEIQMSQPPSTDLSTTAHFISHHSTPLLLNNKNKTQTILEFGTEIYLSIYLSIYLSIYLSIYLSIYLSLIIIYLSIYLSIYLSICEVTERLFAINLSALIRTFFRNDLLILFFRLSFTSQKNHLLLAICFQIIFCDKIILLKCLKLASYPADIQLNIWTLQSQDRIPPPSNNSSSRLDEDHYLAPVASMGETNLSIYLSIYLSIRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DMQ0</accession>
    <name>A0A812DMQ0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_56491</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003733">
        <property type="protein sequence ID" value="CAE1303706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DMQ0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1303706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="219" mass="26524" checksum="1CFD4A6C356A3ACF" modified="2021-09-29" version="1">MDSFPLYLLSLFPLFPCMHRLFSPIFTVSFQPFPVYSFLTLSLDMYGHSSPFSRIFRLFHQFPYIYCLFSPFFPYIYSLSTVFPYIYSLFTLFPYIYSLFTLFLNIYCLFSHFPVYLLFLFTRFLYMYSLFSLFSRIFDFFSPFFLDMYGLFSPISRILTFSFHPFLRMFSLFSPLYPYMYGLFSTLPRIFTVTLQHFVRIFSLFSPFSRIFTVSSTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DNA5</accession>
    <name>A0A812DNA5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_59370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004111">
        <property type="protein sequence ID" value="CAE1307353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DNA5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1307353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="363" mass="40520" checksum="F80D8703FC52B9E1" modified="2021-09-29" version="1">MRHLLGHFVSHSIIRGSFVSFPEPTHRTGPDPGHNRFLETRKSTCLNLHHITSSIASSLPLSLVRSLSLSLSLSLSLSFALSRSLSRSLSLSLSRSLSFALSLSLSLLLSLFRHLSLSLSFALSLSLSFSLSLSLFHSLSLSLSLSLFLFLFLSLFRSFTLFRSLFLFRFLSLSLSPSLSFFRSLSLSLALSRSLSLSLSLSLSRSLSLSFALSLSLSLSLSLSLFICLPVFKICSFCLTCFSLVRQTYKNAVHSLVFVLPTEFVILFKLNYLSIYLSIYLSIYLSIYLCIHVNIYLPFYRSSILEERHAVRAKSTVDRRPRPAKLKGSPTRLQPESSKPTLQRSSAHLPTATSIPSKKSRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DPI3</accession>
    <name>A0A812DPI3_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HYDIN/VesB/CFA65-like Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SPHA_58903</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004061">
        <property type="protein sequence ID" value="CAE1306732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DPI3"/>
    <dbReference type="OrthoDB" id="6286344at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053879">
        <property type="entry name" value="HYDIN_VesB_CFA65-like_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45912">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45912:SF3">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22544">
        <property type="entry name" value="HYDIN_VesB_CFA65-like_Ig"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14874">
        <property type="entry name" value="PapD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="727"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="783"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="domain" description="HYDIN/VesB/CFA65-like Ig-like" evidence="7">
        <location>
            <begin position="109"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="HYDIN/VesB/CFA65-like Ig-like" evidence="7">
        <location>
            <begin position="388"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAE1306732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="819" mass="92354" checksum="A9A67726FFCD0DBB" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DPU5</accession>
    <name>A0A812DPU5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_60171</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004170">
        <property type="protein sequence ID" value="CAE1308285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DPU5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="319"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="380"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="409"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="437"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="465"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="500"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1308285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="545" mass="62893" checksum="80747D5E93949159" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DQV9</accession>
    <name>A0A812DQV9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_60718</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004234">
        <property type="protein sequence ID" value="CAE1308911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DQV9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="319"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="356"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="398"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="455"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="587"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="616"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="648"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="654"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="701"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="707"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="739"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="794"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="801"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="837"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="877"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="947"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="974"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1008"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1037"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1071"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1097"/>
            <end position="1115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1308911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1129" mass="136898" checksum="81905E0313AA7F54" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DU32</accession>
    <name>A0A812DU32_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SPHA_59852</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004148">
        <property type="protein sequence ID" value="CAE1307878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DU32"/>
    <dbReference type="OrthoDB" id="21525at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01374">
        <property type="entry name" value="KISc_CENP_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000177">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF75">
        <property type="entry name" value="CENTROMERE-ASSOCIATED PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5 7 8" id="KW-0505">Motor protein</keyword>
    <keyword evidence="2 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
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            <end position="327"/>
        </location>
    </feature>
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            <end position="396"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
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    </feature>
    <feature type="coiled-coil region" evidence="9">
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    </feature>
    <feature type="coiled-coil region" evidence="9">
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            <end position="854"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
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            <end position="93"/>
        </location>
        <ligand>
            <name>ATP</name>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAE1307878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="906" mass="104025" checksum="299543319D1C5E3F" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DU99</accession>
    <name>A0A812DU99_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_62437</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004467">
        <property type="protein sequence ID" value="CAE1310952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DU99"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="280"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="310"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="340"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="398"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="431"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="467"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1310952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="515" mass="62115" checksum="31920180B65A5B2F" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DWP3</accession>
    <name>A0A812DWP3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_61235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004316">
        <property type="protein sequence ID" value="CAE1309552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DWP3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="452"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="482"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1309552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="523" mass="59953" checksum="E68A66741B83F1AE" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DZ68</accession>
    <name>A0A812DZ68_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_64242</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004626">
        <property type="protein sequence ID" value="CAE1313100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DZ68"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
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            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        </location>
    </feature>
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        <location>
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            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="391"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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            <end position="443"/>
        </location>
    </feature>
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        <location>
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            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="506"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1313100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="528" mass="65346" checksum="7786F073D0DFA581" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DZG7</accession>
    <name>A0A812DZG7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_63510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004549">
        <property type="protein sequence ID" value="CAE1312240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DZG7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
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        <location>
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            <end position="51"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1312240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="320" mass="37430" checksum="5B1AD6FFEC0E9F63" modified="2021-09-29" version="1">MLNVLVNHNSNSVSAITTTRLEKSVFLKNCVPVSYSFFLSIYLSIYLSIYLSPHIFSTFHYVFTSLFSFLFSFFLSFFLSFCHILSVYLSIYLSIYLSIYLSPHIFPSFHSVVTELFSFLSSFLLSFFLSFFLSFFLSFFLSFTVYLSIYLSIYLSIYLSIMTCSLSIYLSIYLSIYLSIFFHMFAILSLSIYLYASNHSAFFPSLLSFFLHSDVSVSRCLAFVLMFSTRWRDKRVSKYKNESLSQHTSLVGQRQSLTFTEMLFFLSIPSCFFLISLCVTSLFLFLLFSFLFFSQFLFLFRLSLDFIFLSRLKYLVGVVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DZH6</accession>
    <name>A0A812DZH6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_63486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004549">
        <property type="protein sequence ID" value="CAE1312207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DZH6"/>
    <dbReference type="OrthoDB" id="1728974at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492:SF95">
        <property type="entry name" value="HELITRON HELICASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1312207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="213" mass="24064" checksum="D773486DA3D7F379" modified="2021-09-29" version="1">MIHGPCRSQYNYTSCHNSDGKCTRQYPPDFVSETITGSDGYPLYRRRSPAEGGFTAVVKGQQVDNRWVVPYCPLLTKAFNAHINVEYCHSFRFINYVCKYINKGTDCAMFGISQEGSVDEIQDFLAGRVISSTEDPWHIFSFPIHKRFPAIVQLAVHLENDERHNTYRVLQTVDRTSLLGRYCTQTCLHTTSGQKRTPGLGGSAEPTSRAIQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E3D0</accession>
    <name>A0A812E3D0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TFPI2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SPHA_63648</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004566">
        <property type="protein sequence ID" value="CAE1312378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E3D0"/>
    <dbReference type="OrthoDB" id="5950222at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00109">
        <property type="entry name" value="Kunitz-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.410.10:FF:000020">
        <property type="entry name" value="Collagen, type VI, alpha 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020901">
        <property type="entry name" value="Prtase_inh_Kunz-CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050098">
        <property type="entry name" value="TFPI/VKTCI-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10083">
        <property type="entry name" value="KUNITZ-TYPE PROTEASE INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10083:SF328">
        <property type="entry name" value="TISSUE FACTOR PATHWAY INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00759">
        <property type="entry name" value="BASICPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00280">
        <property type="entry name" value="BPTI_KUNITZ_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032632931" evidence="4">
        <location>
            <begin position="20"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="5">
        <location>
            <begin position="19"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="5">
        <location>
            <begin position="80"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="5">
        <location>
            <begin position="143"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAE1312378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="191" mass="21600" checksum="16405C54571F9D4A" modified="2021-09-29" version="1">MNLPLLLLMPAVYIMKEYCFQPKDAGTCQEYTSRYYYNSETGICEEFNYGGCKGNKNNFLTEKSCQLICIEGSINRPVECKLPLALGNCPLSLVRYYFNLTSEKCEQFIYTGCNGNLNNFFSLEKCKSQCLNVRPSNLNEAMCSSNPDPGPCMAEIERFYYSSKTGKCYPFTYGGCGGNTNNYNSKESCLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E4F2</accession>
    <name>A0A812E4F2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_67627</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004896">
        <property type="protein sequence ID" value="CAE1316925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E4F2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1316925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="163" mass="17893" checksum="753864E7B9F09B31" modified="2021-09-29" version="1">MLNTPTHRPTDFVQTSSSPRDKCDLTVDRCLSLFFAAPLSLAALSYPSLPSRYPSLPYPIPRCLILSLSALSISLCLLAIPRCLILSLVAFSLSLAALSYLSLPYPISLCLILSLSAFLLSRAALSYLSLPSRYPSLLYPISRCLLAISRCLSLYLAAFIRKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E5K6</accession>
    <name>A0A812E5K6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_65096</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004686">
        <property type="protein sequence ID" value="CAE1314072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E5K6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1314072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="224" mass="26637" checksum="C0DF00607CD3BF50" modified="2021-09-29" version="1">MQVFFSDIASLFQSIYLSIYLSIYLSIYLSIYLSIYLSMFISVYLSVCLSISIYMYVYISSVHIYLSIYLSIYLSIYIYIYICLIDLSIYLSIYLSIYLSIYIYHSNYQSVSIYLSIYLSIYLSLFIHIILFIRLFLSFFLSIYLSIYLSIYLSIYLSMYLCSYISFYLSVCFYLSIYLSIYLSIYLSLSLYLSIYVHIYHSIYPSVSIYLSIYLSIYLSICLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E696</accession>
    <name>A0A812E696_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_65117</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004691">
        <property type="protein sequence ID" value="CAE1314121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E696"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="265"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="517"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="579"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="715"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="844"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="929"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="539"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="554"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="606"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="869"/>
            <end position="882"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1314121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="971" mass="106266" checksum="FFCE5441F9E769A4" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E7R2</accession>
    <name>A0A812E7R2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_69635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005098">
        <property type="protein sequence ID" value="CAE1319250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E7R2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="340"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="376"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="400"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="432"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="459"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="493"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="532"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="558"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="582"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="614"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="650"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="676"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="700"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="735"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="786"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="913"/>
            <end position="935"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1319250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="943" mass="106919" checksum="4FF38A5292D043FC" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E963</accession>
    <name>A0A812E963_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_66726</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004817">
        <property type="protein sequence ID" value="CAE1315872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E963"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1315872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="274" mass="31506" checksum="BE326CE68051C029" modified="2021-09-29" version="1">MPSISLSINISIYRILFIPVSFIFISIYLSIYLSIYLSIYLSLFISISFCYLSIYLFISLYLCVLSIFSLYLSLSLISIYLSIYLFVYLSIYLSIYLSISRCYQSLYLYLSESCVKISLSLSISLSLSVRFSSFLSIYLSIYLSIYLSIYLSILVSSYLSIFLSLLSITVSQCIINLSLSLSVCLICFISIYLSIYLSIYLSIYLSIYLSNVVSRNSKNIYLSIYLSIYLSIYLYQSVHIYLSIYLSISICSYLSIYLSIYLSIYLSVYLSISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E9K9</accession>
    <name>A0A812E9K9_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G-protein coupled receptors family 3 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SPHA_68579</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004998">
        <property type="protein sequence ID" value="CAE1318088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E9K9"/>
    <dbReference type="OrthoDB" id="6133044at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050726">
        <property type="entry name" value="mGluR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24060">
        <property type="entry name" value="METABOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAE1318088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="163" mass="18389" checksum="99B4682E396EEF97" modified="2021-09-29" version="1">MICAYYAFRSRKLPDNFNESRYIAFCVDTTLLIWLSFLPTYFITSRAYHKVLVMSSALIINATVNLICLFLTKLCALYKYRSEYRKNLLQEQELFRVIRSIASDNLDLHSANQKRLGASTGESASVGAPLAQSQSCNNLQQQSLDVPLNTVSLCKSDSNLKAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EAU3</accession>
    <name>A0A812EAU3_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BLOC-1-related complex subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SPHA_69924</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BORCS7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005110">
        <property type="protein sequence ID" value="CAE1319630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EAU3"/>
    <dbReference type="OrthoDB" id="5567844at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099078">
        <property type="term" value="C:BORC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032143">
        <property type="entry name" value="BORCS7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31397:SF1">
        <property type="entry name" value="BLOC-1-RELATED COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31397">
        <property type="entry name" value="BLOC-1-RELATED COMPLEX SUBUNIT 7 BORSC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16088">
        <property type="entry name" value="BORCS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0458">Lysosome</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAE1319630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="195" mass="21843" checksum="F8121CA5F2736312" modified="2021-09-29" version="1">MNDLGSLARQIVRGSHSSELLAQAAKNFAFQENTINNSLDTLKKMDMIKSQLEFQLAAVERSTITLDDIQDHSSFSCSFLSLSLFPFSTTCSFTLLRQSVPFLNASFHFLPKSPASLLSLLSFSSFSEQNFLWVVSILVQTRLLRDSGDWLVDESFLQFRSLRVGCFPSFLLLFASVSTTWKLVLIIGAQFVTCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ED48</accession>
    <name>A0A812ED48_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_71323</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005219">
        <property type="protein sequence ID" value="CAE1321192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ED48"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1321192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="225" mass="26718" checksum="1DD29F0662355B8A" modified="2021-09-29" version="1">MFRLLHLHLMNLIVSSFEHFLLSCLFFVAFFFFFFFSLFYPTDFFFITSHFFVSSPLLLFVFFLFILLISALRCRIFSALPLLPIFQSFYFYILSFLFLCCLSIKCFKVSYFFSPSPSPYISIFLLLYSLFSLSLLFVYKVIRDVVFFSPSPLFLYFNLSFYFYILSFLFLCCLSIKCFEMSYFSALPPLPIFQSFFLLLYSLSSLFLSIPIVSLSDFFLSRCIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EEQ8</accession>
    <name>A0A812EEQ8_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SPHA_73850</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005398">
        <property type="protein sequence ID" value="CAE1324099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EEQ8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="255"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="289"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="313"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="354"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="146"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAE1324099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="422" mass="49679" checksum="316D956BEB72D4AB" modified="2021-09-29" version="1">MTTSPSFFIHMFSSARRAENEHIPSFLIFFFFFRSSSSSSSSSSSSSSSSFVLLLLSFFFFFFLFFIFFFFFRSSSSSFSSSSSSSSSSFVLLLLFLPLLLFLLSFFYFCCCSSSFLIRLLLSFVLSSFSSFVLLLSFFFCCCCSSFILLLLLLLLVPFFFFFFFRSSSSFVVVVLSFFFFFFFFFRSSSFVAVVLISFFFFFFFFFFHSSSFVVVLLSFLFFFRSSSFVLLLLSFFFFFLLFFFFLFRSSTFVVVLLLSFFVFFFRSFVLLFLLSFFFFFFFSFRCSSFVVVVLSFFFFFFFFFFRCSSFVVVLLLSFFFFFFPSSSFVVVVLLLSFFLFFFHSSTSSSHSSFVLLLLSLFFFCWCSSFILLLLLLSFFFFLLLLQSLSLTVTESCLVTNFSIARDDNYSLPLPEISFGSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EFQ3</accession>
    <name>A0A812EFQ3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_73615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005382">
        <property type="protein sequence ID" value="CAE1323757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EFQ3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="286"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1323757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="331" mass="38820" checksum="03B1F0F42E74AD4F" modified="2021-09-29" version="1">MNARKASSYLSIYLSIYLSIYLSIYLSQPPVHNLSIYLSLFIIYLSIYLSIYLSISACSLSIYLSIYLSIYLFIYLSQPVHYLSIYLSIYRSIYLSLFIIYLSIYLSQPVHYLSIYLSIYLSIYLSIYLSQPVHSSIIYLSIYLSIYQPVHYLFIYLSLFIISIYLSQPVHYLSIYLSIYLSIYLSISTCSLSIYLSIYLSIYLSISACSLSIYLSIYLSSVHNPIYLSIYLSYVHYLYLLFYSSIYLSIYQSISACSLSIYLFYLSIYLSIYLSLFIIYLSNSLVYFLSACIFIFILKPPFFQKLVTRSQTSFLFPSSRIVTLQWTMVLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EFR9</accession>
    <name>A0A812EFR9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_74536</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005433">
        <property type="protein sequence ID" value="CAE1324784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EFR9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1324784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="160" mass="18820" checksum="933AE445FFC2778B" modified="2021-09-29" version="1">MFARSVSISLHQAFINVGRPFRLFIRPSFAKKKTCSNCITYATFFFFSLVIVSCFIDIYLSIYLSIYLSIYRLILSSHFFYLLSIYLSIYLSIYLSINSFTSFYLSTPFYCNLSPHSYLSISLLHIYQSFKCHNRFIAIYPSIYLLFKSIYLSIYLSHTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EFS2</accession>
    <name>A0A812EFS2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">PAX2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SPHA_72253</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005305">
        <property type="protein sequence ID" value="CAE1322291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EFS2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001523">
        <property type="entry name" value="Paired_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043565">
        <property type="entry name" value="PAX_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636:SF41">
        <property type="entry name" value="PAIRED BOX PROTEIN PAX-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636">
        <property type="entry name" value="PAIRED BOX PROTEIN PAX-6-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00292">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00027">
        <property type="entry name" value="PAIREDBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00351">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51057">
        <property type="entry name" value="PAIRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0563">Paired box</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EG54</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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        <dbReference type="NCBI Taxonomy" id="158019"/>
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                <person name="Bekaert M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
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</entry>
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</entry>
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    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_75503</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005460">
        <property type="protein sequence ID" value="CAE1325886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EKV3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="279"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="339"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1325886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="365" mass="44223" checksum="A4DB0FD50279DD2E" modified="2021-09-29" version="1">MHTDFFRRFTFLVLLIRFHFLFVLWSYLMFDSFLFSFFFLYFNCRFSPLLFSPLLSPFFSVHFFLFLFLFLNLVSSFSSFESLIDLPFLYILQHYQPFFLHSPFIFLSNFDQFSPSTFLFLLTCLSFRRKSVNITFIRNLVYCKYSLVKFIIYLSIYLSIYLSEFVHIYLSVYLFIYLSLLKSLFYLSIYVCSYLSIFLSNYLTLSHSIHIYLSIYLSIYLSIYLSLLKSISFYFYLSIYLSIYLSIYLSIYLSIYLSLYSHPERFYRDFHIFSCPCNIIYLSIYLSIYLSIYLSIYCFVCSYLSIYLSIYLSIYLLLCLFIIYLFIYGFTCSYLSIYLSIYLSIYLSVCLFYLSIYLSIYLSIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EMZ4</accession>
    <name>A0A812EMZ4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_76995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005500">
        <property type="protein sequence ID" value="CAE1327513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EMZ4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="584"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="611"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="652"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1327513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="689" mass="78070" checksum="6CA906179606955E" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EN91</accession>
    <name>A0A812EN91_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_79122</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005558">
        <property type="protein sequence ID" value="CAE1329702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EN91"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34723">
        <property type="entry name" value="PROTEIN CBG17025"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="339"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1329702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="372" mass="43179" checksum="2BC79261C44EC213" modified="2021-09-29" version="1">MYVFFSIFFFESNPPKSSFFFLSFFLSFFLSFFLSFFPSDPSNLSLNQTIHLFNFFLSQALVFLPGFHESSFFIDIVFHPTSSCLLLPSLFYQFIDQSFQSFDLSIFLSFLSNECIRLCYPMRLCHPALSFVHSLLRSFSFFCSFLCSFLPSFLCSFLPSFLCSSSFLPSFLPSFLPSFLPSFLPSFLCSFVHSLLSFFLPYIHSFRRSFLFFFICSWSFLPSFLPSFLPSFLPSFLPRLSFFLSFFLSFFLSFSILLLSFIFCLFLPSFFHRPPFVRSPFVRSFDPSSSFLPSFLPSFLPSFVLSFLPYFLPSSSFLPSDLVIPSVFVFPSFLDRPSFLPSFLPSFLPSFLSSVAINQIQERVNFFFTQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EQN8</accession>
    <name>A0A812EQN8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_80500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005600">
        <property type="protein sequence ID" value="CAE1331319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EQN8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="314"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="343"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1331319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="367" mass="42074" checksum="E050AD703A59CDE3" modified="2021-09-29" version="1">MLITNAFEESGKIKAAASLNELKYGSTGLLRFFSDEKNFIQDQTSNRQDDSVRSFPSPSWFLASSPARGDVFFQKGLRVTAEIYQEVPRNVQDSASAHKAKTTQPRLLNNVPHHWLSDLWLPSSLDCKYLDYFFWVVIEAKTKKHAHNTVDSPKAAIVEAFAAMDKDMVAKASYLSIYLSIYLSIYLSISVCSLSIYLSQFISIYLSIYLSIYLSIPIYSIIYLSLFISVHYLSYLSIYLSHLFISISVYSYLSIYLSIYLSIYLSIYLSISSIHYLSIYLSIYLSSSIYLSLFIIYLICSIYLSIYLSIYLSHFLNLSLSHSSLSLILFMSTNISTPIYPRLFLSIYLSIYLSIYLSISIYLIPFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EW98</accession>
    <name>A0A812EW98_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_78476</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005540">
        <property type="protein sequence ID" value="CAE1328844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EW98"/>
    <dbReference type="OrthoDB" id="6153212at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="324"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="389"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="421"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="457"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="481"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="515"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="542"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1328844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="565" mass="66991" checksum="F271A56169CB1083" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812F112</accession>
    <name>A0A812F112_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_80785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005610">
        <property type="protein sequence ID" value="CAE1331598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812F112"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1331598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="411" mass="46361" checksum="141B1CD2294311E1" modified="2021-09-29" version="1">MSAHLSIYLSTYTSKYIYIYIIYLSVCLSIYLNIIYLNIIYLSIYLSIFLFTSFYIYLSVCSSLSLSLSLSIYLSMFAHLSIYLSMSVHLSIYLSICSHCFISIYLCLFIYLSIYLSIYLCLLIYLSPIKNAVVIFSLLNLPRENGLSFHRQCPEGFLVYAFNINILSLSLSIYLSEFSHLSGRVYSYLSIYLSIRLQSLFGSLSLSLSLSLYHSPSLSLYLSLYLNLVISLAESIRLSLSLSLYHSPLSLSLSLSISLSEFSNFSSRVYSDLSLSLSLYHSPLSLSLSISLSEFSNFSSRQSLFGSLSLSLYHSPLSLSLSIYLYLNLVISLAESIILSLSIIPPLSLSLYLSLSEFNNFSSRVYSDLSLSLSIIPPSLSLSLYLSLYLNLVISLAESIRIYLSIYLSMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AKE3</accession>
    <name>A0A812AKE3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_696</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000018">
        <property type="protein sequence ID" value="CAE1140828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AKE3"/>
    <dbReference type="OrthoDB" id="8194427at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1140828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="364" mass="43762" checksum="2E0F39BFDA219280" modified="2021-09-29" version="1">MRWGPKLVPRGEMLIGRYQQPDLPLLSARRERRHLSIYLSIYLSIYLSIYLYSLLTSASLPRPRSVSLHQYTNEFYLLQNQEARAEISGIYKERGPGKYLPHFLSLSLSFLPSLLSFLLPCLPVFLSFSQLTLSFSLSFFIFIDDTHCPRKFQPFHFNVLLCFTDCDLSSVEYELSYVYYESSRVDNELFCVDKLFRVDYELFCVDYKLFCVEYKLFRVDYELFRVDYELFCVGYKLFPVDYELFRVDYELFCVDYKLFRVDYELFCVDYKLFPVDYELFRVDYELFCVDYKLFRVDYELFCVDYKLFRVDYELFCVDYELSRVEYELSHVYNELSRQSFSFSLSLSLSLSLSLSIYLSIYLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AM95</accession>
    <name>A0A812AM95_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_3049</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000089">
        <property type="protein sequence ID" value="CAE1150946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AM95"/>
    <dbReference type="OrthoDB" id="10537896at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1150946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="285" mass="31850" checksum="B49BF7C8CBEA9D93" modified="2021-09-29" version="1">MFSVHLIVSVCLYLSIYLSISIYLYIYIYIYIYIYIKSSIHLSLPAFLSFFFVSELFSFIQIYIILSLSLSLSFSLSLSLSLSLVTSCFHLSKYILFSLCLSLSFLSLFLSLSLCLSLSLSLSFSLSLTSSPISFFFSLSLKINLSLSLSLPLSISPSLYFPLSLSPPPLSLSLSLSLSLSLHVCMGSSLDNYDINPRQTHVGFDEQELSVDMYNDDVDYMTKTPVSVLSSSDVLLDSALREHEASKNTRNKHSTFYGELPAYPYVNGTAILSPQNLEHMNTTDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ANU0</accession>
    <name>A0A812ANU0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_2366</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000065">
        <property type="protein sequence ID" value="CAE1148160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ANU0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1148160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="238" mass="29117" checksum="92C414B7E4A15F9F" modified="2021-09-29" version="1">MQNFLFFFKLLFFFLLFSLNFFFSFFFFNFLLFFSFLYSFNLFFFLFLIFSFSLLFNLLFYIFTIFFLFLFSLNFSFLFSFILFQFSLALIFYSFLFSFLHCLVTFSICFYLFSVCRPFSLSFLLVKRPSPFISLSFTASFPFSFLEHFSFFFLSFFLSFFLSFFLSFFIIIFILFILNISSFIYSFQFSSCFYHIFNILFFPFTLFSLLLSIYARFSLFLSIYLSIYLSIYLSIYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ARJ9</accession>
    <name>A0A812ARJ9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_3754</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000113">
        <property type="protein sequence ID" value="CAE1153240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ARJ9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1153240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="161" mass="17619" checksum="92BFE4F92853DF18" modified="2021-09-29" version="1">MSHYITHICVSLFFSFSAGNIILSLSLSLSLSLSLTLSLSLFLCMCLSLIFVSMFCSFSSLFLSYPLLSAVNTMKSVSAFYILSVCLSVSVSVSLSLSLSLSLCHSLSLFLSLSLSFSLYLPLYRSRSHLLFPQHSQKGFERRAGALETSESIIGMSKSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ASB0</accession>
    <name>A0A812ASB0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_5843</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000191">
        <property type="protein sequence ID" value="CAE1159110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ASB0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1159110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="206" mass="23247" checksum="1AE1B86B2CB00756" modified="2021-09-29" version="1">MHRQNHISASIRRSPTQHSLAEPHHIILWQTHISASVRIISSQHSLAEPHLTCIGSTTSQHPYVEAHLIIRWQTHISASVRRSPSKHSLAEPHFTCIGRTISQHPSVEAHLSIRWQNHISSSVGRPTSQHLSAEAHLSISWQNHISSSVGRTTSQHLSVEAHLSIRWQNHITASVRRSPSQHSLAEPHLIIRWQKHISASVRRSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AT73</accession>
    <name>A0A812AT73_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_4233</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000132">
        <property type="protein sequence ID" value="CAE1154538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AT73"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1154538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="277" mass="32976" checksum="2521DD333ECF2A9D" modified="2021-09-29" version="1">MYLCIYLSQPVKIYLSIYLSIYLSIYISIYLFLFSLVSIYLSIYLSIYLCSNVSIYVSQSVTIYLSIYLSIYYDYCFSYLSIYLSIYLSIYSSISRSTYILHYLFIYLYIYLWQLKSLSLSLSTSLPLSFPHSVSHPPLSLKIFITNLISFFLSFFLSLFLSFFHLSDLNSRSIYLSIYLSIYLSIYLSIYLSQFVHYLSIYLSIYLSIYPSLSLSIYLSIYLSIYLFQLVHYLSNYLSIYLSIYLSIHIIQRIVQVKQTYYWLREQREKNIPPLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ATF2</accession>
    <name>A0A812ATF2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_5383</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000180">
        <property type="protein sequence ID" value="CAE1157785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ATF2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="308"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1157785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="365" mass="43077" checksum="739F590EA5B25136" modified="2021-09-29" version="1">MTFTENRRNSLFLVKLHNGVYFFIEETYLAQTLKQLIYLCFLSIYLSIYVSYLSIYLSIYLSIKYKYKISISILPLSISINLSISLSLCLYLSIYLSIYLSIYLSHIHLAIIMSISIYLSIYLSIYLSHNHLAIIMFISIYLSISYPFSYHYLSLCSYLSIYLSHIHLAIIMSISIYLSIYLSHIHLAIIIYLSIYLSHNHLAIIMFISIYLSIYLSHIHLAIIMFISIYLSISYPFSYHYVHIYLSISYPFSYLSISYPFSYHYVHIYLSIYLSIYLSHNHLAIIMFISIYLSIYLSIYLSHIHLAIIMFISIYVSHIHLAIIMFISIDLSIYLSISYPFSYHYVHIYLSIYLSIYLSIYLISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AVL5</accession>
    <name>A0A812AVL5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_5895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000193">
        <property type="protein sequence ID" value="CAE1159296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AVL5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="308"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="337"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1159296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="361" mass="41096" checksum="A30E4F0DCADE892E" modified="2021-09-29" version="1">MILLSFICRETNHRFTSVSFLILSFSLSTYSLSLLILTLSLFILSYSLFSYSRSLSPYSFSLYSYSVFLSLFILSLSLFSLSLFLFCLALSFLILALSFSLFLLSLFLFCLSLSLYSFPLFILALSLFILSYSLFSYSRSLSPYSFSLYSYSVFLSLFILSLSLFSLSLFLFCLALSLFLFALSFPYSPLSILILSSLSLFFSLFILALSHFILSCSLFLILSLFLLILLSLFLFCLSLSLFLFSFYSLSSFILSCSLFSYSALSLLIPPLSILILSSYSLFSLSLFLLSFFCLTLSFLILSPLLILLSLFLFFLLLFFFSLLFSLSLFLFCLALSFLILSLFSLFLLSLFLFCPFSLFIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AWL9</accession>
    <name>A0A812AWL9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_6955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000224">
        <property type="protein sequence ID" value="CAE1161522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AWL9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="309"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="341"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="376"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="402"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="431"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="457"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="489"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="520"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="576"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="608"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="637"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="663"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="690"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="723"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="768"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="794"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="821"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="911"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="945"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="973"/>
            <end position="995"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1161522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1019" mass="118069" checksum="B10210AFF0DA706E" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AY29</accession>
    <name>A0A812AY29_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SPHA_5892</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000193">
        <property type="protein sequence ID" value="CAE1159286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AY29"/>
    <dbReference type="OrthoDB" id="332281at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009316">
        <property type="entry name" value="COG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024603">
        <property type="entry name" value="COG_complex_COG2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024602">
        <property type="entry name" value="COG_su2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12961">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12961:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12022">
        <property type="entry name" value="COG2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06148">
        <property type="entry name" value="COG2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 2 N-terminal" evidence="10">
        <location>
            <begin position="18"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="COG complex component COG2 C-terminal" evidence="11">
        <location>
            <begin position="373"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="462"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="476"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAE1159286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="736" mass="83740" checksum="668B9BF67F530954" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AYI8</accession>
    <name>A0A812AYI8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_6709</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000219">
        <property type="protein sequence ID" value="CAE1161127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AYI8"/>
    <dbReference type="OrthoDB" id="10584171at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1161127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="186" mass="20816" checksum="D76A826DD0124F1F" modified="2021-09-29" version="1">MKVTYIPQKQISTSWVPTHEDNCPLELKPNALTTRPSFCNLLLISSSNEGYLYSAKNKLARVGFRTHEDNCPLELKPNALTTRPSCCNLLLISSSNEGYLYSAKNKLARVGFEPTRTIVHWNLKPNALTTRPSFCNLLPISSSNEGYLYSAKNKLARVGVRTHEDNCPLELKPNALTTRPSFCNLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AYK1</accession>
    <name>A0A812AYK1_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">guanylate cyclase</fullName>
            <ecNumber evidence="2">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SPHA_7133</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="2"/>
    <dbReference type="EMBL" id="CAHIKZ030000230">
        <property type="protein sequence ID" value="CAE1162070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AYK1"/>
    <dbReference type="OrthoDB" id="1890790at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06352">
        <property type="entry name" value="PBP1_NPR_GC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000030">
        <property type="entry name" value="Si:ch211-215j19.12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF501">
        <property type="entry name" value="GUANYLATE CYCLASE 32E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="414"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="474"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="11">
        <location>
            <begin position="801"/>
            <end position="930"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAE1162070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1006" mass="115435" checksum="9341E190BA552C22" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AZP1</accession>
    <name>A0A812AZP1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_7390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000237">
        <property type="protein sequence ID" value="CAE1162645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AZP1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1162645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="157" mass="18781" checksum="8F84A89BABB84982" modified="2021-09-29" version="1">MIHICLSFFLSFFLSFSFFSVIFTITSLYYSSFFLPIIFVMTHICLSFFSFFLFSFFLSVIFTITSVCYSSFFLPIIFVMTHICLSFFLSFFLSFFSVIFTITSVCYSSFFLPIIFVMTHICLSFFLSFFLSFFLFRYLYHHFCLLFFLFSFPLSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B0E0</accession>
    <name>A0A812B0E0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_7739</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000249">
        <property type="protein sequence ID" value="CAE1163592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B0E0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="136"/>
        </location>
    </feature>
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        <location>
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            <end position="175"/>
        </location>
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            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="243"/>
        </location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="306"/>
            <end position="333"/>
        </location>
    </feature>
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        <location>
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            <end position="393"/>
        </location>
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        </location>
    </feature>
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        <location>
            <begin position="439"/>
            <end position="464"/>
        </location>
    </feature>
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        <location>
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            <end position="492"/>
        </location>
    </feature>
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        <location>
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            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="524"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="553"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="579"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1163592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="628" mass="75768" checksum="30B1113EEC02A567" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B1K4</accession>
    <name>A0A812B1K4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_9234</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000294">
        <property type="protein sequence ID" value="CAE1166993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B1K4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="290"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="326"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="376"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1166993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="399" mass="46933" checksum="1A918E4446FCA1F1" modified="2021-09-29" version="1">MISIRSIFILLFSLCFIDFLNQSFLFSSLIWRSTFLFVINIVQISSYLSIYLSIYLSICICSYLSQNVHNFISISICSYLFIHLNLFVSIDLIPSIYLSIYLSIYLSIYLSIYVNLFIPTCLSIYLSIYLSIYLSIYLSIYLSQFLHIYLSIYLSQSHDVFHYLSIYLSIYLSISVYPSISVFSVSTNLSIYLSFYISQYFYYLSIYLRLFIIYLSLSIYLSHSFYLSIYLSIYLSIYLSQSFHYLSIYLSLFTIYLSIYLSIYLSIYLSICVCLYLSQTSLHFLSIYLSIYLSIYLSIYLSIYLSISICSYLLNHFNLLVSLDLIPYLSIYLSIYLSIYLSIYLSISVSSFFIYLSQYVPIYSTISTCSYLLISFHIYLSIYLSIYLSIYLSIYPLLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B287</accession>
    <name>A0A812B287_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_9256</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000296">
        <property type="protein sequence ID" value="CAE1167163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B287"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="302"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1167163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="328" mass="38418" checksum="B6EA3388A4446AE0" modified="2021-09-29" version="1">MIYNQICFCRDLPYLSIYLSIYLSIYLSIIVCSSTYHRVFISLSLSLSIYLSIYLSVFRYLSIYLSIYLSIYLSIIVCSSFSLSLSLSIYLSIYYALTFYLSIYLSIYLSIIVCSSTYHRVFISLSLSLCVQASIYLSIYLSIYLSIYLSIYLSIFLSIYLSIMACLSIYLSIYLSINQSIYLSIYLSHMWFPFGPIFANSLLRWVAHYSPFLLLLHLHLLLLPRKRQRYASCLTCGQNVTHEFLRPYVFDNVFLFSFSHCIKFSRWYGPFLSVCLSVVLSIYLSIYLSIYLSIYLSQSVHIYLSIYLSIYLSIYVCLLIIYFSFFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B634</accession>
    <name>A0A812B634_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SPHA_13666</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000458">
        <property type="protein sequence ID" value="CAE1175409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B634"/>
    <dbReference type="OrthoDB" id="2021138at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF54">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="40"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAE1175409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="311" mass="35109" checksum="5EB4CE89C6B7B1BC" modified="2021-09-29" version="1">MAFFQEFLSELLPLIIVSFHCFLSFAVYLLVILSPPTFPIFLFSSSFILFLVSNMILYSYPLFLFLSLSLSHFLSFFLSLSLSLSVFPLLYLSIYLSIYLSIYLSIYLSITLYAFNNRLKKLSHDVGNLHKLENLDIKNNILGSLPSSVSRLVNLQILDVGNNLLKSLPAALHKCILLRKMFVSRNRIKKLPPSLQKIQTLETVEASNNLIRSLKKTIYMSPAEFNLSHNRLQQLPDVAAKKKKTSMAFLNSAGSSLCASGACSYDGRLCVAIWRFDRHQVPSMPRTGIDGDTRQYISRRARITTTATAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B8W8</accession>
    <name>A0A812B8W8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_12900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000432">
        <property type="protein sequence ID" value="CAE1173979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B8W8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1173979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="233" mass="28022" checksum="B13F3E7917C3BC88" modified="2021-09-29" version="1">MLSFFLSLISFFFLFLSFFKFSFLRFYLSYIFPFSFFNFYISFTHLLMHWSFTHLFIHSFFFSFFLFSHVHFLCVFFTFFLPFCCYLFNCLLPSFLPSFLPSFLPSFLPSYSYSNPHLLFLSLLNFSPCMIFTFLSFHFHFSFLPSFLPSFLPSFLPSYSYSNPHLLFLSLLNFSPCMIFTFLSFHFLFPSFLPSFLPSFLPSFLPSFFPSFLPILTLILIYCFYLYSLFPRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B9Z0</accession>
    <name>A0A812B9Z0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_13013</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000435">
        <property type="protein sequence ID" value="CAE1174211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B9Z0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1174211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="253" mass="27825" checksum="81D9FAA97E7EED1D" modified="2021-09-29" version="1">MPFRPLSVLSTLNHISRLFPFCLLLIPLSPLFYFYLLIPFRLFLFCLLLIPISFPFCLLLIPRFASFLFCLLLIPPFASFRSALNPRSPLSVLSALNPVSPLSVLSALNPLFLGLFLFCLLLILFSPLSFCLLLIPVSSFSVLSALNPVSASFFPSFPFCSVLSALNPLSPLSVLSANPRFASFCSVCSLIPFASFCSVALNPLSPLSVLSPLSVLSALNPLSFLSFCSVYSFFRLFLFCLLIPVWPLSVLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BAQ7</accession>
    <name>A0A812BAQ7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_13935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000471">
        <property type="protein sequence ID" value="CAE1176015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BAQ7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1176015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="223" mass="25744" checksum="29CFE3307928415D" modified="2021-09-29" version="1">MDLSIYPCPSLSHYVWIYLSMSLCMDLSIHVRLSHYLSIYLSIYLSIYLSMCGFVYLSAAVFSYLSIYLSIYLSIYLSIYLSIYVCLSLSLSLSSACVDVCIYLSQSFHIYLCPSLSLSLSLSFPLSLFPSLSVYGYIYLCPSISLYLSMYGFVYLSQSIHIYRSLFISIYLSIYLSIYLSIYLTFTISIYLSIYLSIYLSIYYRSYISVYSLLFCLSFSTNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BFR4</accession>
    <name>A0A812BFR4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_14785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000508">
        <property type="protein sequence ID" value="CAE1177697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BFR4"/>
    <dbReference type="OrthoDB" id="1421090at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1177697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="178" mass="20772" checksum="FDFB52B6F0219C48" modified="2021-09-29" version="1">MYISMCVDLSIYLSIYLSIYLSIYLSMSVYSDLSLYLCQSIQIYLSKSIEIYLSIYLSIYLSIYLSQSIQIYLSMYLSQSIQIYLSIYLSLFRSIYLSIYLSLFRSIYLSISVYSDLSIYLSIYLSISVYSDLSIYCVPFFDGIKSLYYNWFNSDSLSLSLSLSLSPVRESEMRVSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BG15</accession>
    <name>A0A812BG15_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_15978</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000558">
        <property type="protein sequence ID" value="CAE1226350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BG15"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1226350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="311" mass="36710" checksum="254B72DF7E7F44CC" modified="2021-09-29" version="1">MWHSFRRSNLSDKLDLPSRLPSSYLPLSEHHKIRETHVFICHPFCSSSSFFFLFLFLLFFFFLFCFRLLFPSFIFLYLFVILSVPSFSSSSPPPPPPPLLSLFQTPFSFFYLFIFICHPFCSSFFFSSSSFSSSSSSSSSFFVTDSFFFFYLFIFIWHPFCSSFFFFFFFFFTSSSSSSSSSFFVSVSFFLLLSFYIYLSSSLFFILLLLAFSFLLLLLLFQTPFSFFFLFLYLFVFLSFFLLLLLLLLHLLYWNACFTFFYIVIFIKICSSSSYLILIPLLLLFQVKTSFYVVIFLCISSSPSLLLFLFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BGP2</accession>
    <name>A0A812BGP2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_16309</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000570">
        <property type="protein sequence ID" value="CAE1227159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BGP2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1227159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="233" mass="27616" checksum="C0928764477B3430" modified="2021-09-29" version="1">MYAQHFSLIFFLLQYIYLPRLLSIYLSMNINVSVRDNMYIFNIKSIYLSIYSSIYLSIYHRMVKYCESIYLSIYLSIYLSIYLSIYLSHSVLSIYLSIYLSIYLSSIYLILFFIHPSIYLIQFLSIYPFIHLSIYPSIYLSISFSFIYLSIYLSIYLSIYLIQFYLSIYLSISFCSLSIYLSIYLSIYLSIYLSIYVCIIAFTHARTCTYLSIYANFLRLACAKSQWCGPQIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BI46</accession>
    <name>A0A812BI46_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_18036</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000646">
        <property type="protein sequence ID" value="CAE1231051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BI46"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1231051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="158" mass="18634" checksum="CD144582E9E22AF9" modified="2021-09-29" version="1">MYTSLFQSITVCLYLCLGHCLFRCVHTYPFLLSSVCMSLSVSHFLSVSLLSAYLSIYLSIYLSIYLSIYLSIYHNVFLSRPGLLINFFLSFFLSFFLSFFLSFYHSLFISNYSYLSLYLCLFISIYLSIYLSYFIYSYLSDSIHYLSIYLSIYLSIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BI61</accession>
    <name>A0A812BI61_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_20714</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000760">
        <property type="protein sequence ID" value="CAE1237313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BI61"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
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        <location>
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            <end position="328"/>
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        <location>
            <begin position="378"/>
            <end position="400"/>
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    </feature>
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        <location>
            <begin position="412"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="442"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1237313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="533" mass="61803" checksum="027111C7748EE7E4" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BJR6</accession>
    <name>A0A812BJR6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_18024</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
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            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000597762">
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        </location>
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        <location>
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            <end position="628"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1231046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="630" mass="74035" checksum="88EC006A066FFC17" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BKJ4</accession>
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    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
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        <dbReference type="NCBI Taxonomy" id="158019"/>
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            <strain evidence="2">Farmed</strain>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="456" mass="52220" checksum="2E572F638CE2DF36" modified="2021-09-29" version="1">MPIYGTNLSIYLFSTICLFISIYPSIFVSLSIYLSQSLHIYLSISVSLSIYLSQFISIYLPSLFIMYVSIYVSNLFLSLSLSLSLSLSIYLSIYLSIYLSQSVHYLSLFISISLSLSLSLSIYLSISVSSYISIPLSLFLCLSIYLSQSLHIYLSIYLSHSSLHIYLSIYLSQSVHYLSLFISITLSLSLSLSLSIYLSIYIYIYRYRYLHIYISLYLCLSVYLFISVSSYLSICLCLFISVNSYLSIYLSIYLSIYLSIPVYSLCMYLIYSYLSLSLSLSLSNYLSISVSSYLSISLSLSLCLSIYLSQSLRIYLSIYLSIYLSIYLSSIHIYHSLSLSLSLSLCLSLSLSIYLSIYLSIYLGLFISIYPSLSIYLFISVCSYLSIYLSIYLSIYLSIYLSLCVCLYIHKRRDVWLSFFFYLLLMDPTEILSLMVFPVQSPYTKTDSSSEGRITF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="2">OLFR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_18983</name>
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    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
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        <lineage>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
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                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
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    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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            <begin position="180"/>
            <end position="201"/>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAE1233504.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="203" mass="22861" checksum="C1EDC15979D93892" modified="2021-09-29" version="1">MVEVHHPRQDPASTFTLHLSLFVLVYLLSVSALSLSFSLSLLVLLYLLSAPLSLFVLVHLLCVHPDPSLSFCSSAFILCSLLALFWYIYCLFLLHTLSLFSYIFSLAHCLLICPFLLLSLSLSLCSGISTLCLPHLFFYPPFLVYRISVTPSLSLSLFILVHLLSILFYKLLTIFLIDRYGVGAISIYLSIYLSIYLSIYLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
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        </submittedName>
    </protein>
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    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
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        <dbReference type="NCBI Taxonomy" id="158019"/>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
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                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    <dbReference type="Proteomes" id="UP000597762">
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            <begin position="39"/>
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        <location>
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        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1236188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="208" mass="24323" checksum="0462547A95439673" modified="2021-09-29" version="1">MLGHPINGSCVILTRFIYLSIYLSIYLSIYLSISICSYLSIYLSIYLSIYLSIYLSQSVLNYLSQYIAYVYPYVSIVYVYMYVCMHACIYLSIYLSIYLSIYLSIFIICALIYLSIYLSIYLSIYLNLLLSIYLSIYFNLKLLSIYLSIYLSIYLTDLVQIQVSTVKPLHNTILICSYLSIYLSIYLSIYLSILIYSYLSIYLSIYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BMX6</accession>
    <name>A0A812BMX6_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VWFC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_19607</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000711">
        <property type="protein sequence ID" value="CAE1234976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BMX6"/>
    <dbReference type="OrthoDB" id="6516201at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008201">
        <property type="term" value="F:heparin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051586">
        <property type="entry name" value="PKC-binding_NELL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001007">
        <property type="entry name" value="VWF_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24042:SF5">
        <property type="entry name" value="EGF-LIKE CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24042">
        <property type="entry name" value="NEL HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00093">
        <property type="entry name" value="VWC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00214">
        <property type="entry name" value="VWC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57603">
        <property type="entry name" value="FnI-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01208">
        <property type="entry name" value="VWFC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50184">
        <property type="entry name" value="VWFC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFC" evidence="2">
        <location>
            <begin position="38"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1234976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="164" mass="18883" checksum="5149A632F1F0E844" modified="2021-09-29" version="1">MCSLCKCTNGVTKCEPKECKCNAPDVNLNCCPQCTKKGKCEHQEEPRLMAHGEKWIFQCQTCECLNREIDCWPLECPQLTCSQIIKVPGDCCPRCVNDEPCHENDRYSIVNVGLPVEVCRYRGRRYQNNEIWKLDGDRCTSCKCKRGHICCSFNQTCTDLERFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BNP3</accession>
    <name>A0A812BNP3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_20076</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000735">
        <property type="protein sequence ID" value="CAE1236087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BNP3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1236087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="233" mass="26282" checksum="AAB4B0EB9E6F8DF2" modified="2021-09-29" version="1">MAHNYLKSEQLTIIHQPRGRTKKQNKTIPTFTSFRVLCRLLLMSSTTVAAYHEKKSFFYVERPLSTSLLSTYALGKCFLSLCFLDVWGGVEVDGWECVKVEGDGALAREVGKLLDLGQIASSSLFFFFDAHLFLLFKEEDDGRAFHQCPYRNAAAFSVSLRRIPSSKEISRLVAKVRCKWARLRPGSGKRSWCRPMTVPVTVFFEDEEILILSLSLLSHSSLSLSLSLSLSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BPG2</accession>
    <name>A0A812BPG2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_19768</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000719">
        <property type="protein sequence ID" value="CAE1235406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BPG2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1235406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="150" mass="17555" checksum="929900EE10ECF376" modified="2021-09-29" version="1">MERDKLLCCQICYFRFVPLIGTPFGNTGFCLTRVYQLLFLNIISLSFLPSLTGGVLSQQDTRSDFCAHTSFILHNNLIRSLVIYFGSYLSIYLSIYLSTQDFIYLYLFIIYLYIFVHIYLSIYLSIYLSVYLSIYLSVLVHIYLSIYLSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BSL7</accession>
    <name>A0A812BSL7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_22190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000818">
        <property type="protein sequence ID" value="CAE1240218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BSL7"/>
    <dbReference type="OrthoDB" id="2020457at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1240218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="155" mass="17433" checksum="ACB65717A924305C" modified="2021-09-29" version="1">MVRDAIVCYAIVRDAIVWDAIVCYAIVRDAIVWDAIVCYAIVRDAIVWDAIVCYAIVRDAIVLDTSNLLSCLGSQMVRDAIVCYAIVRDAIVWDAIVCYAIVRDAIVWDNCLLRNCPGRDCLGRNCLLRNCPGRDCLGRNCLLRNCTGRNCLRHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BSX8</accession>
    <name>A0A812BSX8_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_24707</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000926">
        <property type="protein sequence ID" value="CAE1245386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BSX8"/>
    <dbReference type="OrthoDB" id="6277218at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF74">
        <property type="entry name" value="POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="2">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1245386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="350" mass="38605" checksum="EB1E00B38C82F5F2" modified="2021-09-29" version="1">MNEDLFVDYMLHFIEHTRCTKERPVLLILDNVETHITINTIDLARENGVVLLTLPPHTSHRLQPLDRTVYGPFKKAYNAAMDGWIHSHPGRTVTNYDIPTIVSEAQLCAMSQRSIKTGFAATGIYPYNKDIFVDADFASTAVTDRQNPEANADAADLDPIPGPSSGAVGSPPIPRPSSCGMGQQPVSSSCEYVSPSAIYPFPRAEPRKTKGGRKKRATKILTDTAVRDELAAEKAKVKPTKDIKKKLFSQTSQKTTANVTSDDDSDDEDCESMAMNDSDDDDVSDDELIEGDFVVVSVNGKKTTRRYIARVDVIDGDELEGVFLKRIQGRKPMDGRQAFIIDPDSLDKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BU21</accession>
    <name>A0A812BU21_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_26934</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001030">
        <property type="protein sequence ID" value="CAE1250048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BU21"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="279"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="310"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1250048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="386" mass="45527" checksum="7D78B89E3DA9C7F5" modified="2021-09-29" version="1">MIFYPYCFFFFFFCFAPPFFVFPFLLLCFLHISVLLHHLFFYQHSSFSSSSTLFLLLLLLLLLLLLLLLLLLSFYFSFPFSLFYLYPFLCSFFLSFFLSFFLSRFLLYFILFFLFCQYFFSFFFSPFTSISVFFPSSFYLYLYFPILPIMTQHSQEKKISTTHRLFLSLSPYFLNSVTSLSLSLSLSLSLSLSVFCSFFLFLALFLLLSFVQRLLILYFCLSLFLTFSHLFSPPPPLSLSISFMCFLRVYSVFFFHSILFTLTISSGLSLSIPTLPFSLHVIFSLIVVFLFKSAKFILFLFLIFSVHIYLSIYLSIYLSIYLSIYLSIYLIFTSVSSSIYLSIYLSIYLSIYLSIYLSQSVHYLSIYLSQSVHYLSIYTLSVYLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BU59</accession>
    <name>A0A812BU59_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Spectrin beta chain, non-erythrocytic 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Beta-III spectrin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">SPHA_23649</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">Farmed</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Probably plays an important role in neuronal membrane skeleton.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cell cortex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the spectrin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000875">
        <property type="protein sequence ID" value="CAE1243140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5865767at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051693">
        <property type="term" value="P:actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd21246">
        <property type="entry name" value="CH_SPTB-like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21248">
        <property type="entry name" value="CH_SPTB_like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10571">
        <property type="entry name" value="PH_beta_spectrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000020">
        <property type="entry name" value="Spectrin alpha chain, non-erythrocytic 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000003">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000004">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000011">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000018">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000019">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000028">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000033">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000049">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000059">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000083">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000106">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000024">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002017">
        <property type="entry name" value="Spectrin_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11915">
        <property type="entry name" value="SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00435">
        <property type="entry name" value="Spectrin"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00019">
        <property type="entry name" value="ACTININ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00020">
        <property type="entry name" value="ACTININ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0117">Actin capping</keyword>
    <keyword evidence="9" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="2312"/>
            <end position="2337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="2344"/>
            <end position="2366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="2372"/>
            <end position="2398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="2405"/>
            <end position="2431"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="18">
        <location>
            <begin position="50"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="18">
        <location>
            <begin position="168"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="17">
        <location>
            <begin position="2666"/>
            <end position="2774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="2091"/>
            <end position="2110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="2117"/>
            <end position="2291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="2772"/>
            <end position="2813"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="452"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="779"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="991"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="1243"/>
            <end position="1301"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="1627"/>
            <end position="1654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="2119"/>
            <end position="2129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="2168"/>
            <end position="2187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="2213"/>
            <end position="2225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="2278"/>
            <end position="2291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="2776"/>
            <end position="2790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="2801"/>
            <end position="2813"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00054264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00070730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00077032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CAE1243140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="2813" mass="322111" checksum="E2B326CE5EFB2522" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C124</accession>
    <name>A0A812C124_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_27862</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001092">
        <property type="protein sequence ID" value="CAE1252178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C124"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1252178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="203" mass="25027" checksum="EE61BA1E47D78AA9" modified="2021-09-29" version="1">MCFLSANQTKLSFFLSFFLGQNGSFHSFFQGFSFFLSYFFFLSFSRAFLLSLDRLFFFPFFFFGFFILPLLFFQSFILFFFLSFFFFHILSFLSFTFLSFHFQFFLSAVFIFLFFLSFFTSTFIFLSFFFFSFFRSFFCFFTLIFLSFFLSLFFFLSFFLHLTFLSFFLSPRRFSFCLKISFFFLSFSFFLFSFFSFFLSFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C1J7</accession>
    <name>A0A812C1J7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_28112</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001106">
        <property type="protein sequence ID" value="CAE1252738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C1J7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="361"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1252738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="386" mass="43986" checksum="DE01822D865D5064" modified="2021-09-29" version="1">MTLYRTLNQKPQEASTNLSIYLSIYLSIYPSLSKPIYLSLSRSIYLSIYLSIYPSLSKPIYLSLSRSIYLSIYLSIYPSLSKPIYLSLSRSIYLSIYLSIYLSIPVYLSIYLSIYLSIYPSPSKPIYLSLSRSIYLSIYLSQSIYLSIPVRPNLFILACPDLSIYLSQSVQTIYPNLSIYLSIYLSIYPSPSKPIYLSLSRSIYLSIYPSPSKPIYLSLSRSIYLSIPVRPNLFILACPDLSIYLSILVRPNLFILACPDLSIYPSPSKPIYLSLSRSIYLSIPVRPNLFILACPDLSIYPSPSKPIYLSLSRSIYLSIYLSIPVRPNLFILACPDLSIYLSIYLSIPVPLSSKNTLADSFYTLFLSIYLSIYLSVFCFFFIIINQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C2I8</accession>
    <name>A0A812C2I8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_27213</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001046">
        <property type="protein sequence ID" value="CAE1250608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C2I8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="273"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1250608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="306" mass="35091" checksum="855EF83BA30709CD" modified="2021-09-29" version="1">MSSKYTGCRNTQSITIQISRNHINMAVMPLNLSTFIYFLFISFNFSINYSPLSIPLLYPFPLFIYSSPLSIHTHYLFILSLSITPHYQFLSIYSYSFSILPLYLYLLSIYSFSIPLSYLFPLYLFLLSIYSSPLSIPPLYLFILSISSFLSSSCLFFLSIYSFSLSIPSLYLFIPPLYSSSLFLFSIYSPSLFPLSLFSSSLFLLYLFNPSIFSFSLSIPLLYLFLLSLYSSCLFITPLYSSSPFISPLCLFLLYLFIPSLCSSYLSIPPLPLFLFSIYPSSPSILLLSYSLLPIFRFRFPAILAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C566</accession>
    <name>A0A812C566_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_29837</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001196">
        <property type="protein sequence ID" value="CAE1255833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C566"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1255833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="185" mass="21448" checksum="27E6CDAC06E72E0D" modified="2021-09-29" version="1">MSSIDEKPLSWFIRLIHDTCIHLNKSMLLLCLFNSNSTMSSIDEKPLSWFIRLIHDTCIHLNKSMLLLCLFHSNSTMSSIDEKPLSWFIRLIHDTCIHLNKSMLLLCLFNSNSTMSSIDEKPLSWFIRLIHDTCIHLNKSMLLLCLFHSNSTMSSIDEKPLSWFIRLIHDTCIHLNLCCSSVIPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C701</accession>
    <name>A0A812C701_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_28847</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001136">
        <property type="protein sequence ID" value="CAE1254213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C701"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1254213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="281" mass="32524" checksum="8977105392E1E68C" modified="2021-09-29" version="1">MSPFFFQRWLRIPTEIYQEIFDEYGEALDGRDRRRMPLRLSAGLLHTRPRRPSSGCSTMFLTTGRRTCGRFPHPTAIPLTISSGGVIAAKTNKNAHNTVDSLKAAIVEAFAAMDKDILILVYTINLSIYLSRTFSVSTIFFLSFFLSFLVIISYCLHDSTFFFLTIYLSIYLSIYLSICLSIYLFQFIHFLSIYLSIYLSIYLSWTFSFFLCLSVISVIIFFVYMILSSFFPSFYLSIYLSIYLLQSYTITCSDQWLKMASSELTSIYLSIYLSIYLSTNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CA56</accession>
    <name>A0A812CA56_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_35521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001531">
        <property type="protein sequence ID" value="CAE1267262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CA56"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052394">
        <property type="entry name" value="LRR-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114">
        <property type="entry name" value="LEUCINE RICH REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="353"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="383"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="414"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="444"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="487"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="517"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="544"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="569"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1267262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="592" mass="67565" checksum="06F195A6351469EA" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CBG6</accession>
    <name>A0A812CBG6_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Tyrosine-protein kinase BAZ1B</fullName>
            <ecNumber evidence="3">2.7.10.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">Bromodomain adjacent to zinc finger domain protein 1B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="32" type="ORF">SPHA_30364</name>
    </gene>
    <organism evidence="32 33">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="32" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="32">Farmed</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 24">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the WAL family. BAZ1B subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="32">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="3"/>
    <dbReference type="EMBL" id="CAHIKZ030001221">
        <property type="protein sequence ID" value="CAE1256757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="784962at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090535">
        <property type="term" value="C:WICH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140801">
        <property type="term" value="F:histone H2AXY142 kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15628">
        <property type="entry name" value="PHD_BAZ1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15541">
        <property type="entry name" value="PHD_TIF1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22249">
        <property type="entry name" value="UDM1_RNF168_RNF169-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000131">
        <property type="entry name" value="tyrosine-protein kinase BAZ1B isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047174">
        <property type="entry name" value="BAZ1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047256">
        <property type="entry name" value="BAZ1B_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018501">
        <property type="entry name" value="DDT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028942">
        <property type="entry name" value="WHIM1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028941">
        <property type="entry name" value="WHIM2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013136">
        <property type="entry name" value="WSTF_Acf1_Cbp146"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46802">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE BAZ1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46802:SF1">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE BAZ1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10537">
        <property type="entry name" value="WAC_Acf1_DNA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15612">
        <property type="entry name" value="WHIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15613">
        <property type="entry name" value="WSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00571">
        <property type="entry name" value="DDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50827">
        <property type="entry name" value="DDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51136">
        <property type="entry name" value="WAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14 22" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="13 25" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17 24" id="KW-0539">Nucleus</keyword>
    <keyword evidence="33" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0804">Transcription</keyword>
    <keyword evidence="12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="15" id="KW-0829">Tyrosine-protein kinase</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 23" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="WAC" evidence="31">
        <location>
            <begin position="22"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="DDT" evidence="30">
        <location>
            <begin position="451"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="28">
        <location>
            <begin position="1035"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="29">
        <location>
            <begin position="1038"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="28">
        <location>
            <begin position="1125"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="27">
        <location>
            <begin position="1373"/>
            <end position="1443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="149"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="395"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="969"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="1093"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="1191"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="25">
        <location>
            <begin position="707"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="26">
        <location>
            <begin position="395"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="26">
        <location>
            <begin position="424"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="26">
        <location>
            <begin position="971"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="26">
        <location>
            <begin position="1097"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="26">
        <location>
            <begin position="1198"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="26">
        <location>
            <begin position="1262"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="26">
        <location>
            <begin position="1283"/>
            <end position="1307"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011903"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
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    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00051245"/>
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    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00061696"/>
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    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00069894"/>
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    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00076449"/>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00475"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
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    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="PROSITE" id="PS50827"/>
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    </evidence>
    <evidence type="ECO:0000259" key="31">
        <source>
            <dbReference type="PROSITE" id="PS51136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="EMBL" id="CAE1256757.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1491" mass="171814" checksum="958A8219BE75A73D" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CBX9</accession>
    <name>A0A812CBX9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_31972</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001326">
        <property type="protein sequence ID" value="CAE1260032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CBX9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="342"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="378"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="403"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="432"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="464"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="493"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="526"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="561"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1260032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="590" mass="69427" checksum="8D73816DC59D4BC4" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CDB6</accession>
    <name>A0A812CDB6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_33911</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001429">
        <property type="protein sequence ID" value="CAE1263868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CDB6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="12"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="322"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1263868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="487" mass="57836" checksum="147F932B773D79B0" modified="2021-09-29" version="1">MSRSFIFISTFAFLFFFSVHLSFFHFLIFFLILLFYYISFYYFPYFNSFLFILFYTNFSSSFFPSFFLATLHPLFNIIYVSVLPPFFLRCFDVVKRLSFISFISVASSLYIQTFFPSLNPFFGLAIFFFSFFSSQLLIIVFFLSFFLSFFLSFFLPSSILRHYCLLFIFLSFFSIISILIAYSLYLQSLLPFIFLCFLCLSSIFILSFFLSFFLSFTHMPFLFNLFSFNYFFISFFHSPVFSNFPPFLSFFLSFFLSFFFLPPSFRLQHFCAPFFFLSFFLSFFLSFLLFPFKLPLFLSTIFSSIFLYFFLYSFIPSFLNIIVFFFLSFFLFFFLSFFLSFFLSFFLSNLIPTLNQLSTYSSIILPLAKHPTEIFYSQLNKYQSSLSFFHLFRSMQDYTTGFFSYLDHENNNLEQIGCDRGGSGTYNNCSAINNKTTRSSEQDGFLENGKEEKWRENDSGCGVLVKWESDEGNLHKGEEIRLGVGRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CEJ1</accession>
    <name>A0A812CEJ1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_34573</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001470">
        <property type="protein sequence ID" value="CAE1265200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CEJ1"/>
    <dbReference type="OrthoDB" id="8957827at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21698">
        <property type="entry name" value="PROTEIN (PUTATIVE)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21698:SF4">
        <property type="entry name" value="PROTEIN (PUTATIVE)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="307"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1265200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="331" mass="36983" checksum="6BCF48047B93FEA4" modified="2021-09-29" version="1">MKNAFTSPFNFLFLTINRFIFFVLIDIYHYVCFFLSVCLSLRDPVCLSLRDSVCLSLRDSVFLSLRDSVCLSLRDSVCLSLRDPVCLSLRDSVCLSLRDSVCLSLRDSVFLSLRDSVCLSLRDSVLLSLCDSVLLSLRDSVCLSLRDSVFLSLRDSVCLSLRDSVCLSLRDSVFLSLRDSVCLSLRDSVFLSLRDPVCLSLRDPVFLSLRDPVFLFLRDPVCLSLRDSVCLSLRDSVCLSLRDSVCLSLSVYFCLSSSLYVILSYSLYVILSASLYVILSASLYVILSASLYVILSASLYVILSSSLYVILSASLYVILSSSFYVILSAFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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    <name>A0A812CH01_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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            <taxon>Coleoidea</taxon>
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            <taxon>Sepiida</taxon>
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            <taxon>Sepiidae</taxon>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001625">
        <property type="protein sequence ID" value="CAE1270042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CH01"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="204"/>
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    </feature>
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    </feature>
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            <end position="281"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="315"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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    <feature type="transmembrane region" description="Helical" evidence="1">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="433"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1270042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="458" mass="54876" checksum="EBF4DC94DD0027C7" modified="2021-09-29" version="1">MTLVSIECDVIFDSVAVSDVLYVCPLLHSLSLSLSLSLSISLSFFTLSVSHSHFPFSTNSTISIFYMLCLSSLFHFSFFSFILSFSFANFCHFTFLFLSRSHFLQPLLFVLHNFTFSSFHFYDLSRYFYLSPIFSFFASFSFLHYISLFFRLGMHSFFFRFCLLAVYLFFDFSNLHSFILSFFFSFLFKIFLTAFFLSFFIQLFLLAFFFFFLVSVFLICIFSFLFHLSYLHSFILFFFQLFIPVFSFFLSFFLSFFLSFFLSSTFLTCIPSFCFFFQLFLPAFFCLSYFLVSTFLICIPCFFSINFFSPVFFSFFLLSYSFFSFLFFFLSFFLVSTFLTSIHSFYFSFFISFFIYLFLSFFLSCFNISNLHSSFLFLSTLFISILFFLSFFLSFFLFSTFLTAIRSFFFFLCNFSHQHSFFLSFFNISNRHSFFLFFLSTFLTSILSFFLSFFFQHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CJL3</accession>
    <name>A0A812CJL3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_38210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <source>
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</entry>
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</entry>
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    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1269992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="862" mass="97112" checksum="4EC5C72B49B7A7A0" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CPF3</accession>
    <name>A0A812CPF3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_41110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001968">
        <property type="protein sequence ID" value="CAE1278255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CPF3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1278255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="229" mass="26134" checksum="8FCB1A349506C77A" modified="2021-09-29" version="1">MSLLFLSLSISCHFCRLFSVAFFSRRFSFVAPPIFPAIFSDALTSGASFLFWFISNSLLSLLSFVFFFIHLLLHFNPTLILLLLILLHFPSSLCFFIFYLTLHLLYSSSTPSLLLIILPSSSSSSVLSLLIPIHIIFRLVYISLSFPSLTSHPSYKCNSLLLSTYLTPSLRFLFILFSYQFPPSRPSSSSSSSSSSSSSSSPPPPPSFFFFFFFFFFFFFFFFTRCLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CPV2</accession>
    <name>A0A812CPV2_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_42772</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002107">
        <property type="protein sequence ID" value="CAE1281250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CPV2"/>
    <dbReference type="OrthoDB" id="6042110at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-type lectin" evidence="1">
        <location>
            <begin position="130"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1281250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="237" mass="26441" checksum="C2B1FBBFEF9C1EF1" modified="2021-09-29" version="1">MRYFRLLRWCRRPFPLHSTSLSLSHSLSLPLSLIISLHISLPPFFSLPSLSSHPFSPPLSLSLDLSLIISLPISLPPSLPPSLSLPSLSLLSPFISPPLCLSPSHSFFLGINIYICIHVRVRLYEWLEGYLASLSNTSATWWTGLNDRNVEGVWKWADDSQTPPDMSLIKWNGQPDNKNGNENCAAIFYEGRYADLNCNTPASFICKKSLTGGANKIQTNTFSFLFLVTAFSTLLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CRD1</accession>
    <name>A0A812CRD1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_40750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001935">
        <property type="protein sequence ID" value="CAE1277590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CRD1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="222"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="70"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="239"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="294"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1277590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="314" mass="35757" checksum="65F94069A169B2D7" modified="2021-09-29" version="1">MDNDKLSSIIKETEANLMRLKQQYRSREPQISTYKHTGARNLPPPIEMDTPANRSSSLFLGFLNQIKGQLDEQSQTLHKINSTVQKLEAENALYKQELMTAHTNIHQLSSLLDNERRKSHLSLERHFIQMQEMLRLSQNATYLRPQNDVYEDALKFYQKVKKRPTTVASTDFQNPLNSSSNLQQMSTKCKSAPCPQPFVPEPQVMSSLNSIQKMLHLRQSRKKIHNKTSRTDASHSKMSNTSSDQDLDSSSNQTITISSTQNLTLQSDEDLHSDDSNFDLLDSRSFGKSEDGLESSSSEDLMSECESYCSEKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CS85</accession>
    <name>A0A812CS85_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MAK11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SPHA_40740</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Farmed</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Negatively regulates the PAK1 kinase. PAK1 is a member of the PAK kinase family, which has been shown to play a positive role in the regulation of signaling pathways involving MAPK8 and RELA. PAK1 exists as an inactive homodimer, which is activated by binding of small GTPases such as CDC42 to an N-terminal regulatory domain. PAK1IP1 also binds to the N-terminus of PAK1, and inhibits the specific activation of PAK1 by CDC42. May be involved in ribosomal large subunit assembly.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001935">
        <property type="protein sequence ID" value="CAE1277595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CS85"/>
    <dbReference type="OrthoDB" id="308449at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051959">
        <property type="entry name" value="PAK1-Kinase_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44675:SF1">
        <property type="entry name" value="P21-ACTIVATED PROTEIN KINASE-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44675">
        <property type="entry name" value="PAK1 INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="38"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="80"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="121"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="314"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="339"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00045213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAE1277595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="365" mass="41049" checksum="94F39243B146D3E9" modified="2021-09-29" version="1">MAEYADLEIIVGTYEEILLAYRVTVVGEEWQMEESFTDHSHLGSIRNVAVSKRRGFLASGGTDETVWLYSLKSRRLIGSLTQHTGSVTYLQFHQGSHLFSCSEDGTLCLWKTFTWECLRTFKGHKGGINCVAVHPSGKLALSVSKDKTLRAWNLLKGRRAYVTNLYRVADLVIWSPTGDNYILVFGNKIEVYLTENAALTRIIEASGRVNAVLFVTDSLIAFAGESSEIEFYDIVKDASQHKITFSSTRTRGLCFKKLPSGKEILISACSDGFIRIWNVSLTTDGITTKCLLQHNSTFRLTCLDAFVNVPKQPSATRELKTKNEEQQSEEETLSPLPVKSKEHLSKRARHEEGVEITKKKKKKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CTI4</accession>
    <name>A0A812CTI4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_44630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002280">
        <property type="protein sequence ID" value="CAE1284184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CTI4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1284184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="179" mass="21360" checksum="0E63E3E2370198B0" modified="2021-09-29" version="1">MIDIIYLSKPVHKPVLLIYLSIYLSIYLSIYLCFILFIIYLSIYFVLFISIYVLFSSYLCFIMFIIYLSIYLSIYLSIALVFSTSFFFFSFFLSFFLLLPLLLLNAISISFRMITFSLYLFQYLSIYLSIYLSIYLSISDRKIHLYHNTIYLGQCISIYLSIYLSIYLSIYLSIMEPYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CTY8</accession>
    <name>A0A812CTY8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_43228</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002157">
        <property type="protein sequence ID" value="CAE1282098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CTY8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="313"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1282098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="377" mass="43518" checksum="58BF952E0E9529B7" modified="2021-09-29" version="1">MTLYFLTFLFLYIYLSICSAYIVSLSIFLFPMISSIFFCILFFLYLSFLAFTLPPSKSSFSFFSFFYFRHSHSPLVNLHSSLFFISGSIHTPPSNSSFSFLFFLAFILHSSLFFLIQAFTLPPSNSSFSFFSFFFTSGIHTPSFFNSSFQHSAFPSSNSSFSFFSFFLLQAFTLPPSKSSFSFFSFFYFRHSHSPLLILHSHSSLLFTSGIHLPTSNSSFSFFSFFLLLAFKLPSSHSSFSFFSFFYFWHSHSLLLILHSHSSFFFYFKHSHSLLLILLSHSSLFLLQAFTLPPSNSSFSFFSLFYFRHSHSLLLILPSHSSLSFFFFSFSFIHIPPPSNSSFSFFSFFTSGISPPQPNSSFSFFSFFTLAFKLPPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CXL3</accession>
    <name>A0A812CXL3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_42832</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002112">
        <property type="protein sequence ID" value="CAE1281311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CXL3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1281311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="160" mass="19047" checksum="FF39861BE931C3ED" modified="2021-09-29" version="1">MAIAWGNLFKIYLPTSVSYIFPNAVIEFFDDSTQRNHREKAMPPFLHFFVIKAKIEHQRRISVGHLCHIYLSIYLSIYLSIYLFNCLSIYISIYLFFYVCLHLSIFVRLYTSIHLIYPRLFTSIYLSIYLSIYLSIYLSIYVHYLSISRSALYVAVIYET</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D3T5</accession>
    <name>A0A812D3T5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_48179</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002656">
        <property type="protein sequence ID" value="CAE1290404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D3T5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1290404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="218" mass="27098" checksum="2C49C0D6B00E6023" modified="2021-09-29" version="1">MLNWKKDRRNVLFYFSFLKFNIYLYIDKLIVSIYLSIHLSIYLSIYLFIYLSIYTFYLSIDKYSLSIYLFIYHSFNIIYLFIHHWIYLSIYLKFIIHSFIYLSIYIYIHIYIYLSIYLSILLYLSIYIYILCISILFIFYSKLSIHMSIHIILFLSINSFIYWFIYLSIRLFIIYIHLYNLYIYLSIYWSIIIAIIYINLSIYSVHIYLNSIYKFSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D4Q1</accession>
    <name>A0A812D4Q1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_48697</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002722">
        <property type="protein sequence ID" value="CAE1291222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D4Q1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="322"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="355"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="384"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1291222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="464" mass="52648" checksum="C3CEE164E96FF158" modified="2021-09-29" version="1">MIVWFIMSFLNANIVAILTSLIFSFESVCLSLSLSLSLSLSLSLLNFYWFTLSLSLSLSLSLSLKHTQKHALSLFYFLPNLLKGSLSSFFHFLSLTLNPSFLSISTSLSFSSLSLSLSLSLIFTRSLSLPYYHSFFLFLFIFSLFLPYRFFLSSLSLSLSLSLSALFSFFNPCFYSSVSFPYSLSTSSFHSFSLSSLLSIFLSPFLFPLFLSFYSFIFTLSLSINLNCLFLFSPSPYISVFLSLLILHFYLSLPPSPSPLSLSLFLSLCLSLSLSFPLSLPSYHEKQKSTTKPFNIHVYLFIFSSCFLIFFLRPLLSLSLSFFLYLSFSFPLSHFIFLPLSLFASHTFYSSLSLFFSFFPPSLSLFHAIVTVSLFFVISDILSFCYYFLSLFLSLSLFFQFIHFSSNAAELKVVSTQHHPGLITREILSGISTRPQYAVRSDRTITMEECTCLKAVAKTCLQET</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D4W1</accession>
    <name>A0A812D4W1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SPHA_47118</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18703">
        <property type="entry name" value="MALT1_Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50208">
        <property type="entry name" value="CASPASE_P20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="112"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="206"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="282"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="Caspase family p20" evidence="1">
        <location>
            <begin position="389"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1297159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="775" mass="88481" checksum="E3A4F735860BB5F9" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DEC0</accession>
    <name>A0A812DEC0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SPHA_51852</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003174">
        <property type="protein sequence ID" value="CAE1297181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DEC0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052258">
        <property type="entry name" value="Diverse_Func_Domain-Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37612">
        <property type="entry name" value="FIBROIN HEAVY CHAIN FIB-H LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37612:SF19">
        <property type="entry name" value="FIBROIN HEAVY CHAIN FIB-H LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="196"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="277"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="370"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="228"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="204"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="294"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="311"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="323"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAE1297181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="513" mass="54842" checksum="4DC57FF88E274FFF" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DEY7</accession>
    <name>A0A812DEY7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_54963</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003632">
        <property type="protein sequence ID" value="CAE1302346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DEY7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="13"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1302346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="325" mass="37993" checksum="777FC56758AA4F3D" modified="2021-09-29" version="1">MFYFTSVFLYSSLYAYLSIYLSIYLSIYLSIYLSILLGKKNKQFFHVSSSRLSFFSFFLFFNSYLSIRVYPILSIYLSIYLSIYPSQFIYLSIYLSIYPSQFISVCTYLSIYLSIPVSSSQSAHIYLSIYLSIYLSIYLISHLSSIYLSIYLSIYLSIYHVLFIIYLFSTLSIYLSIYLSIYLSIYLTIPVSSSQSAHIYLSIYLSIYLSIYLSICKSIFFHPPLSLCCTLLSYWLSGNIELKYIRSSVVEKHRRFFRLLYNFLSSTSLTIAFISDMFRTIRLGTANTNTKLCFIIENIVYCLPLFTPFTGGKNGFFFFFPFNTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DI57</accession>
    <name>A0A812DI57_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_56854</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003794">
        <property type="protein sequence ID" value="CAE1304194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DI57"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1304194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="338" mass="37837" checksum="D2D7FCEF03E271AD" modified="2021-09-29" version="1">MTPRRFPPARLSSFFLSFFLPSFLPSFLSFFLSFFLSFFLSFFSVSSSLIDVCTSFSFSFSSYYPLSFLPDTPLCLISVHHSLPPCPHTTPFAFFLLPPLCLISVHHSLPFCPHTTPIPFFLIPPLCLISEHHLLPPSPHTTPFPFFLLPPLCLISVHHSLPPCPHTNPFAFFLLPPLCLIPVHHFLPPCPHTTPFTFFLLLPLCLISVHHSLPPCPHTIPFAIFILPPLCLISVHHSLPPCPHTIPFAIFILPPLCLISVHHSLPPCPHTTPFIFFLLLPLCLISVHHLLPPCPHTTPFAFFLLPPLCLISVHHLHPPSPHTTPFSSSSLFDSCTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DJD7</accession>
    <name>A0A812DJD7_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein SEC13 homolog</fullName>
            <ecNumber evidence="6">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="28" type="ORF">SPHA_54007</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="28">Farmed</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="23 30">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22 30">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Autophagosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Lysosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat SEC13 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="28">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="6"/>
    <dbReference type="EMBL" id="CAHIKZ030003464">
        <property type="protein sequence ID" value="CAE1300726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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    </evidence>
    <sequence length="1693" mass="192264" checksum="BD4BD5FDAA8C5368" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="3" type="ORF">SPHA_58132</name>
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        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
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            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
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            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="914"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="939"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="966"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1056"/>
            <end position="1069"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1305753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1595" mass="177259" checksum="8406927A0B71F813" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DKI6</accession>
    <name>A0A812DKI6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_55295</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003667">
        <property type="protein sequence ID" value="CAE1302946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DKI6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032589091" evidence="2">
        <location>
            <begin position="27"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="290"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="334"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="364"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1302946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="383" mass="43486" checksum="30F21AAFA8C413E0" modified="2021-09-29" version="1">MRNRTFFPSSSSSVLILLLLPLFVSSSFCYLPHPSHSVFFIIFSFFFSSSFSLPHSSSSSSVLLLLLLLLLITSSSSSFGSPPVPRLSSFTVHLLILLPSSSFCPPPPPLPFSSLPLPPLPFLLLSSFSFFLFCSPLPPPPPPPSFSVLLILILLLFLLLHLLFLFIFFCSPPSPPSFVFLLLLLFVFCHCCCCSSFFSSSAPLPFLLSSSSSSSSFCSPPLPSPFSSSSVLLLRLFLLSLFFCCLLFPSCFVLFFLLLLLLFLFSFFFFFFFFFFFSTYPFSSFLSSSCFLLLFLLLVLLLPFLFSFFFFFFFFFFFSTYPFSSISSPPPPPLFVLLLLLLLFFFSSSSSSFLFTLSSTLFIFLRYTDVNLFFYYISFFFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DL13</accession>
    <name>A0A812DL13_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_58306</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003978">
        <property type="protein sequence ID" value="CAE1305979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DL13"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1305979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="235" mass="28283" checksum="0600CB6C0FD0E25B" modified="2021-09-29" version="1">MLYIIIYPSIYLFDIIFIHPSIHLSYLSSYHIFNIYLSFIYYLCIYLFIPFIVQLFIYYPVYHIYLSISSVVHIHLSIYLSIISFIYLSSIVYLFIFIHSSIYISFIYLSIIYLSHIHHLSVHLSIYLSIHIMIYSSIISIYLLSIYLSIYPSIYLIYSLFIYLSIIYLSIYLSIYHLSSPYIHLSIIHIHLFIYSFIIISIYLSIYLSIYLSIYLSSIYLSIHIIYLFIIYHYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DLM9</accession>
    <name>A0A812DLM9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_54505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003542">
        <property type="protein sequence ID" value="CAE1301617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DLM9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1301617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="275" mass="29414" checksum="D09F0F5D123916CC" modified="2021-09-29" version="1">MKIRSEESKFSLSLSLPTLSLSLSLSSSLSHSLSLFLSPSSSLFLSLLLSLSLPLSLLSPLSLFLSPLPLSTPPSLSFFLSLSLPLSLFSSLSLFLSHSLSLSVSLRLSLPTVSLFLSLFLSLLLSLSFPLSLPSISLSLPPSLSLHSSLSLSLSLRLSLPLRLSLPLSLSFSPSLSVPPSLSPPPSLSPLRLSLPLSLSLSLSLFLPLFLSLSLRLSLFLSLSFLLSLFLPLSISPYLSPPLSLPLSLSLSLSLSLPAPETLGIRHSRNYKHVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DMK1</accession>
    <name>A0A812DMK1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_57168</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003842">
        <property type="protein sequence ID" value="CAE1304606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DMK1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1304606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="259" mass="30488" checksum="354A346264AFD3ED" modified="2021-09-29" version="1">MLFFVVVAFSVTCSLKPQMYTLPLVEFSVEGNSLDTCTTRHLKRLPVGNNYFSCLLFFLFLLISLSLSLSLSFFLSFFLSLSLSFYFFMSFTFFFRDHMFKSSSHSFLNTNVFIYIANQLHYLSIYLSIYLSIYLSIYLSIYLSIYLSIYLSQPVHIYLNLFISIYRFIYLSQSVHIYLSIYLSIYLSIYLSISICSYLSQSIYLSIYLSIYLSIYLSSHSRMFINIYTPTTTVCSYLPVCLHKYLYLLIFFSFCQSPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DN79</accession>
    <name>A0A812DN79_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_54852</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003615">
        <property type="protein sequence ID" value="CAE1302231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DN79"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1302231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="265" mass="32037" checksum="C6D3EA87F50A560B" modified="2021-09-29" version="1">MILNLLSLILLFSIVFYFLSSIFSFLPLASYFLFFFYSFPFCLFILFHYIFPLFLSFILFLFFIIWLLPVIFSFFHSFPFCVFMLFYYFFSLFLYHLFFLFFSSIFFFAHDFFSSTTFFIFYPYSQKELLVLLSLSIFQKYLSLLFITNICPVFLSHFHNLLFFFLLSTLSFHLLIFFTNPLFASSSHPSNPLLSFFFLSFFLSFFLSFFLSIVVAFLFVLHFLFLELMNLTFLSLCPLISFFLSFFLSFFLSFFSDTYHSFFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DNU1</accession>
    <name>A0A812DNU1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_57749</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003908">
        <property type="protein sequence ID" value="CAE1305287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1305287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="2233" mass="255981" checksum="205C21BCE364A4C4" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DQW3</accession>
    <name>A0A812DQW3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">LHX3_4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SPHA_57470</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003877">
        <property type="protein sequence ID" value="CAE1304949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DQW3"/>
    <dbReference type="OrthoDB" id="10068367at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000219">
        <property type="entry name" value="LIM/homeobox protein Lhx3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050453">
        <property type="entry name" value="LIM_Homeobox_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208">
        <property type="entry name" value="LIM/HOMEOBOX PROTEIN LHX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208:SF128">
        <property type="entry name" value="LIM3, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="76"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="78"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="136"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="204"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="206"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="226"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="277"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAE1304949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="295" mass="32428" checksum="D05582900B40C18D" modified="2021-09-29" version="1">MVVFSIIRHSIFLRSPLSAETFFGLHSLVCFPLVHFLRCCLLPPLLRVDRCKGTLLDVVSNDIVVLFAFSEYDLDGGNKRPRTTITAKQLEALKRAYNESPKPARHVREQLSVETGLDMRVVQVWFQNRRAKEKRLKKDAGRQRWSPYFRQMKRNGDPDSSLSADDRSDDGLTEASYASEYPYYGRIKIILKILLPVAYPRQIANSSSSSSSSFSSSADDDDDDSSPPPPSSSPPPPSSSSSSSLPPPPPPSSSSSSSTPPPPSSSSSSSTPPPPSSFLLLLLLNNNNNNNDAKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DTY2</accession>
    <name>A0A812DTY2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_62149</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004414">
        <property type="protein sequence ID" value="CAE1310569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DTY2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032745859" evidence="2">
        <location>
            <begin position="21"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="311"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1310569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="412" mass="48324" checksum="DFAAFF55F5498AF7" modified="2021-09-29" version="1">MFHSLVLTFLLPISPPLSLSFRAFNNYLCFGLDKTNIYLLSPLVSLSLLPPFRSVLFPFPGPLLSLSTSPHQRSVFSLFRPTFVPFSLSSPPSFRFLSLLPLRSVFFPLSPPFVQFSLPFRSLCSVFSPLSFALFSFLSLSPPFVQFSPPFSFALFSFLPPFVRFVQFSLPFRSFVQFFSLSFLCSVFSPFRSLCSVFSLPFSFLCSVSLPFRSLCSVFSPLSFALFSFLSPFVRFVQFSLPFRSLCSVFSPLSFALFSFLSFILLPFRFSRLFPMIIFHFSLHLSFFPLFLSFLFFFLSFHSFFLFSFSFFLSTLSFFSLFLSFFPLFLSFLFLSFHSFFLFSFSFFLSTLSFFLSFLCFHFRFFPLSPYFYTFSNFYFVVFFFFFFYHYEDILFSFHFFLYSELAYSSFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DUF2</accession>
    <name>A0A812DUF2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_60999</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004276">
        <property type="protein sequence ID" value="CAE1309229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DUF2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1309229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="230" mass="26800" checksum="0F19EC9C3D6CDAFA" modified="2021-09-29" version="1">MSFIKSVHLSAYIYFCLFFFIQSLFLILSLSLHFLISVSVKLFTTLSMSFISVHLSAYIYFCLFFFIQSLFLILSLSLHLLISLSVKLFTTLSMSFISVHLSAYIYFCLFFFIQSLFLILSLSLHLLISVSVKLFTTLSMSFIKSVHLSAYIYFCLFFFIQSLFLILSLSLHLLISVSVKLFTTLSMSFISVHLSAYIYFCLSFFIGSYHIFCLPFCFKYKKNKRFLNSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DW60</accession>
    <name>A0A812DW60_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_59631</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004126">
        <property type="protein sequence ID" value="CAE1307623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DW60"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1307623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="238" mass="27875" checksum="EDD2B8BCF73185D3" modified="2021-09-29" version="1">MDSISSFHFTSIYLSIYIKILTIYIDDRFLSHTLSLYVYLSIRDCSYLSIYLSIYLSVCLSVHIYLSIYLSIYLSIYLSIYLCSSSIYLSVCLFISYLSSVCLFISIYLVSPHIYLSIYLSIYVCSYLSIYIYIYLSRSVHIYLSLLISLCLSHSVYIYLSISIYLSIYLSIYLYIYIYIILLYSFISIYLSRSVHIYVSLLISIYLILFPSIYLSIYLSGIGCARCSFTQYRKLLQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DZE2</accession>
    <name>A0A812DZE2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SKP2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_65037</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004683">
        <property type="protein sequence ID" value="CAE1313976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DZE2"/>
    <dbReference type="OrthoDB" id="2095648at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="187"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="250"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1313976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="295" mass="32941" checksum="72C5FE731B9E07D5" modified="2021-09-29" version="1">MVNQKESHKSKNTDQEKENAPNRKRKSSDSHSGSAAQKPKTKWTADGDNYPCIYNELGAPRVMVTSHIENHPTKDSPKKNQTSKYAFLKGDDDFIRRRKKVPEVSRNKSESLWKRLDLGNKSLKEGILGQILNRGVVILRLSRAQISSPIYTGLTSVFSSTKLSKLQYLDLSMTCVSVQELYQSASLFIIAAFSLSLSLSPILFSLSLSLLFSSLSPILFSLSLLFSLSLSLLFSLSLSYSLSLSLSPILFSLSLSPILSSLSYTLFSLLYSLSLSYSLLSLHHPHPKYIFFPPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E031</accession>
    <name>A0A812E031_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_62250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004436">
        <property type="protein sequence ID" value="CAE1310727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E031"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="419"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="503"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1310727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="525" mass="58357" checksum="B61E8958E0E5F0E3" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E380</accession>
    <name>A0A812E380_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_63534</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004553">
        <property type="protein sequence ID" value="CAE1312285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E380"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="301"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1312285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="419" mass="49948" checksum="27333FCE9C83CC58" modified="2021-09-29" version="1">MTPPPICLLLRITGSPFLDHVHHPSGPSNLKRFSSVNITFLKSTWFVIHLLALPSLASLCFLVSVILFLILASSSSISCSFFCTVRTLTSSSHFSFTFFAVIFSPDDNNLCFPFFSSFFLSFFFIFPSFFLLFHSSSSSSYYYYYYYSLTFLSFLSSDTLLLSLSTSPCCSHLRLHFFRSFFFITCYLLLRRRLLLWFHFPFLLLLLLLLLLLLLLLLLLLLLPFPFLLLYFFFFFDSPSHFFFFFFFFFFFFFFHFPFLLLHHLLLLYFFFFFDSPSHFFFFFFFDSPSHFFFFFEPPSIFLLLLLLLLIIPFPFLLLHHLLLLLLFFFFFFCKQLFQTIFSHNFKPHIPNNYSFFHFFLQFTIFCKPPYCTFGFQLPPQNSYPTLILPNIPHATCHLISVDKEPGNLDARRRSDVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E3I3</accession>
    <name>A0A812E3I3_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_63976</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004601">
        <property type="protein sequence ID" value="CAE1312805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E3I3"/>
    <dbReference type="OrthoDB" id="10070415at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1312805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="221" mass="25472" checksum="D77A6614CB6D6E6B" modified="2021-09-29" version="1">MQKYRMQRSLKNENHISLNVLSIYLSIYLSIYLSACLSVYLSISVCSYLFESTPVYSVFVDFQKVFDNVNKDVIWRLVHHYGLPPKLVNIIQQLYEDATCQVIHDGTILRAHWSSSGISAVVDDHFSGGRLNNAAGQDRQENCLLFFIVSLFLISPLSPPPPLSLFNYFINPFSFSFFLSVIIITFHASFSLFLSFSFFFINNSTRVFFSSFFLSSFFLYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E5L3</accession>
    <name>A0A812E5L3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_67628</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004896">
        <property type="protein sequence ID" value="CAE1316879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E5L3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="323"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1316879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="353" mass="42766" checksum="DAC88F58C3DA5D2A" modified="2021-09-29" version="1">MISTRQSQMEENEDCVTPMQNPDIFLHDSSIVLTLPPALQLLLYSLFVFSHVIINICSFFLLSIICFLFSIISFFFLFLRFSLIKACLFYYFRIFYSKYFLFFSLILTIVISFFFFHSLNLCVFLSFFLSFFLSFVFLSFFLSFFLSLITFSIYYFLYLFLIFLFFFFVSFCYSLYLLSSSFFLSVIIFYSFSLSLFLLSFFLSFFLFHSLLLIFFVTFIFFCILLLLLFILLSFFLFFFLSFFLSLIYIYFLIFYSLFFILHSFFISFFSLYRLFLYPSSSLAPFIHHWYIFISSFYSLSYRIFLSFLSFSSPLIFRLFLNFYPLFLNTFLSFSFILGFSFLPFFTYITNLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E5V7</accession>
    <name>A0A812E5V7_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SPHA_68956</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005039">
        <property type="protein sequence ID" value="CAE1318512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E5V7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="212"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="248"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="315"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="351"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="379"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="412"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="436"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="137"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAE1318512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="461" mass="56064" checksum="2378F0AD6275FB3B" modified="2021-09-29" version="1">MLLSFFLSFFLSFFLSFFLSFVLSFLFVIGPFSKECPPFLSSYNLFSLLHTFNVSFSFFFSFFFDFFLSLFYIIIFLDSYFTNFFLFLCSFHLLSFVFFSFFTFSIFFHFIHMLSFFHFLLSFFLSFFLSFFLSFFLSFFFLISVVFIPMLFSFLSFFFFLSFLSFLFLSFFLSLLFLSLCSFPFFLSFFLSFFLSFFLSFLLFLSLCSFPFLSFFLSFFLSFFLSFFLSFFLSVLISVLFIPMLFSLSFFLFSFFLSFFLSFFLFFFIPLSFFLFFFFFFSPCFFPFFLSFFLFFFSSLFFSLLFFPFSFFFPFLFLSFFLSFFLSFFLSVLISVVFIPMLFSLSFFLSFFLSFFLSFFLSFFLVLISVLFIPMLFSFLSFFLSFFLSFFLSFFFFLSFFLVVFIPMLFSLSFFLSFFLSFFLSFFLSFNFVLFFIPMLFSLSFFLSFFLSFFLSFLNRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E5X9</accession>
    <name>A0A812E5X9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_64949</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004679">
        <property type="protein sequence ID" value="CAE1313931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E5X9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1313931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="302" mass="34234" checksum="DB1BA86F6C3D3699" modified="2021-09-29" version="1">MWGLERTNKLHTHTHTHTHTHTHTHTLISINLSISSFLFFLSIYLSIYLSVSSFLSFSHSISSFLSIYLSITLFIFSFLYPSVSSVPYLSIYLSIYLSIYLSISSFLSLSHTLSLSLSLSIYLPEVVGGKKIILNLRHLYIHSYNYYYYFIFFVYLFIYPSSLSLCVSLSVYSPSLCLSVCVSIHPISLCLSICLPFFLSLYISVYLSIFSHSICLSIHPSLSICLSTLSLSVYLSVYLFILSLSLYLSVSPSIPSIYLSIYLSIYLSIYLSILFLSLSVYLFVYLSTHPLSLSVCFISGCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E8A1</accession>
    <name>A0A812E8A1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_66537</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004804">
        <property type="protein sequence ID" value="CAE1315686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E8A1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032451034" evidence="2">
        <location>
            <begin position="17"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="290"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="318"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="374"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="407"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="435"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="473"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="499"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="528"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="555"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="591"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="627"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1315686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="655" mass="77556" checksum="6495F5EDBBBA2AAC" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E8F2</accession>
    <name>A0A812E8F2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_67609</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004896">
        <property type="protein sequence ID" value="CAE1316926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E8F2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032694033" evidence="2">
        <location>
            <begin position="21"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1316926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="296" mass="33494" checksum="4436003E82D32B3D" modified="2021-09-29" version="1">MQTFLASCLSLFSLAGGVHSDQYFHLFLSFLSLSLSLFLSVNLSVCLSVSTSSFFSKMPIRPHSLPAALATPSPHPTSSCSLLAWYFQPARAWPNAGCLLFDGVIILGVGVRGPQDVAKKKACIIVRKLGLSKRTGHSWLKLHQTISVRRIFRLNSLSLSLLLLSLVVMAAAALIFSFFFFFFFFFFFFFFINNSHILFRYFALLTFVPLDIIISCEPILSLSLSLSLSLSLSLSLSLSLSHKYISFFPGCFLFFFLFFYSSISTLIGVPFIFFHFLSFFLSFFIYLFIYLFIFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EAU8</accession>
    <name>A0A812EAU8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_70983</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005201">
        <property type="protein sequence ID" value="CAE1320810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EAU8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="315"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1320810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="402" mass="46207" checksum="C94D0F3EB38DEFA6" modified="2021-09-29" version="1">MINPFFSLIFSRSPFYDVCLHCHPFNSFVNHISVVLPLLLLSPCLSLSLSLSLSTHLSIYIALPPQSTFIESIHFPLRLPLFCFSIFSLLFFLFFILFRFPPFLPFFFVYHFLLSPTFFLFLHCFHLTLSLFDFFFSSISFSFPYLFYFFIFFFFSSSFFILFFFCTLHGFIFLLYIILFIFIYSIFQFLFFINFLYFALPFSSFSSSSTSFSSSTSFSSTSYFSSFSTSFSSTFSFPSSSTSFSSFSSTSSTSFSPSTSFSSSTSFSSFSSSSTSFSSASFSFFSSSSASFSSFSTSFSSSTSLSSSSACFLRIVYFFYFLFHFLFSFYFLAISSFLSLATSSSRPTSFSRLFLIHFLHHTFVICFPSHHRPIISLLPLSITPSHFLYFSLYPSLSFSLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EBS3</accession>
    <name>A0A812EBS3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_68033</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004932">
        <property type="protein sequence ID" value="CAE1317434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EBS3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="401"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="440"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="477"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="512"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="558"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="592"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="624"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="659"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="684"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1317434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="712" mass="81618" checksum="0A09DB8F0DE122C9" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EBV4</accession>
    <name>A0A812EBV4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_69814</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005106">
        <property type="protein sequence ID" value="CAE1319397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EBV4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1319397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="229" mass="26683" checksum="BC19F5B594CEFBD0" modified="2021-09-29" version="1">MVIFFIYLSIYLSIYLSIYLSISVYIDFIDGNIFYLSIYLSIYLSIYLSIYLSQIFTLFLLLLLLLLLLLLLLLLLFLPLFFCSSTSIISSFSSFLFLIVSSSSSSSSSSSSSFLLLFLLNYFYFFFFFSSFSCSYSSSSSSFIHPPFSSALRLQLFLLFSSSFLFLLFFLFFFLLLDLLLLLLLFFPILLRLLHLYFSLNSFNITFPFFLSFFLLPLLLLHLYPGFIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EF42</accession>
    <name>A0A812EF42_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_69756</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005103">
        <property type="protein sequence ID" value="CAE1319366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
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        <location>
            <begin position="594"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1326849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="627" mass="74033" checksum="FE70DCBADB74932D" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EMJ0</accession>
    <name>A0A812EMJ0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">OLFR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SPHA_76412</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005489">
        <property type="protein sequence ID" value="CAE1326874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EMJ0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="271"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="63"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAE1326874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="296" mass="35227" checksum="D5C653A031C78E2A" modified="2021-09-29" version="1">MALKELPFCDRRLPHFSYLSLSLSHSPLSLSLSPLSPLSLSLSPLSLSLSLPSLSPLPLSLSLSLSLSDFILVTIFLLTYIFFFFFFFLFSFFLTFFLPSFFLSFFFHFSFFLCPLFSFFISTFSFLSFFLSFFLSFFFFSVVLSFSLSFPLSPPPLSYSFLLYFLLFVISFLFLFSFFLSFFLSSVFLSFFIFFLLYFSLHSFLFLSFFLLSFFFHFLSFFLSFFLSFFLLPTFFSFLSFFLPFFFLSSFFPFSCFSLSFFFLPFSFFLFFLSFFLSFFFLSFFLLSCLFYLSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ENI7</accession>
    <name>A0A812ENI7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_77273</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005511">
        <property type="protein sequence ID" value="CAE1327857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ENI7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="226"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1327857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="348" mass="40634" checksum="E421DFB0A2BA4288" modified="2021-09-29" version="1">MTQAKKLTSQHTDTAAPLSLSLSLSLSPFLLILFFRSLLFIIFVSLFLFVALSFPPLFTTSLISYSTFSHPEILSTRYFLLPPYASLSLSLSPSLSSLPFPLSLSLSLSLSLSLLERHTKKINKHFLLFFYSAPCYFLSILLSWLLLLFLLIFFKIFLFSFFFSSSFLFFFLFAFINLFFFYLSFLFLFYFSLSTFSFCILFFSLSLPFFLSFLFFIIFISTFSFLFQFLFFLFLFFLILFYLLFFFFSFFFLSVLHFYHIYAFPILINSAKYQPGVLCIKETKLPLSFQSTKKLVAQPNLPFYPHLFFCPLSFSRSFHFFPSITSPTPSSSYTSSSRSSNPSDNNYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ERE1</accession>
    <name>A0A812ERE1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_77157</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005506">
        <property type="protein sequence ID" value="CAE1327732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ERE1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1327732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="247" mass="28643" checksum="4D339FABB99BBE5E" modified="2021-09-29" version="1">MLLSGFSLFSTLPCPSHFSLPLSISNDLLTLSVSFLSFMQGCKSYHFSSLFSLYGAYNFLPYFPPPPFIICLSFLVISSSFDFIQRISRYFLLYLCFYYFFHPLHFITFLFSSSSFLAFFIPSFINLLILFLPSFLPSFLPSSSFSLFSTSLSLLFFHPLYSIFTYSLPYFFLSFIFFSPHPLIFFFHLLSSFSYSFFLHLLSASPLFFYSYFSSSSPFLPFFLVLFSFSSLLTSFISFSPSSLFFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ESJ3</accession>
    <name>A0A812ESJ3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_76680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005495">
        <property type="protein sequence ID" value="CAE1327171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ESJ3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="305"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1327171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="400" mass="46774" checksum="4325B22C4BE30262" modified="2021-09-29" version="1">MERFAFIFFFFNLCISFYLFCWLIFFFFSFCSFFLFSLSLSLSLSLSRLFFYSLLSPIFFLFRTFFHSFFFFNLLYFVYFVSLVLFLLVLSQSIYLSIYLSIYLSIYLSLSLSLSHYLSISHILSVYFFFHILFFIVIFYRCIFFLLIALVVFLSFSSVVRLFFSFILFLSFTLKAPTSFSFFHFFQIFPIDFHLFSVYLLLHSNDVKIELTLSLFLSLSLSLHEETPPPHRYNVKRGLFISFCVHYLSIYLSIYLSQSIHIYLSIYLSNYLSTIYLSNIIYLLDCLFTAADIIQNIHLNSSRDIFTSFLSLFFFSSCPGAWQHSLLMSLSIFLSFCLRTWVTIKLKLLSLSLSLSLSLSLSLSLSLSSRSSGLGIQVTDKSKLSSISLSSRCSDIPRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EWE8</accession>
    <name>A0A812EWE8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_80695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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            <strain evidence="2">Farmed</strain>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <source>
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</entry>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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            <dbReference type="EMBL" id="CAE1148089.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AL77</accession>
    <name>A0A812AL77_ACAPH</name>
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        <submittedName>
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    </protein>
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    <organism evidence="8 9">
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        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="CAE1142795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="259708at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12429">
        <property type="entry name" value="RRM_DNAJC17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034254">
        <property type="entry name" value="DNAJC17_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052094">
        <property type="entry name" value="Pre-mRNA-splicing_ERAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44313">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44313:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="11"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="79"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAE1142795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="331" mass="37771" checksum="EAB429E8AFD9506F" modified="2021-09-29" version="1">MPSSNDITKLDLYALLEVTDNATKKEIVSAYRKKALKCHPDKNPDNANAAVEFQQLSSALQILTDVAAKAAYDKVWKAKKAAKVRHKELDSKRKKLKEDLEAREKAYDEKKSKEELSQKDLQAEIERLQKEGSRLLEQEQQLLKEQMRKEHQETSTAQSVPGALPRLKYQSNFILYLIKWKAAKGDKTNGGYSLEILEKIFSAYGEVTALVVSSKKNGSAIVEFPTTTIAQKVLLCEHGHEENPLTFSWIDAATGPKVTPPPVPSKWDNDDEDDNFLIHKTPTQFGQQTYMYQPMTAQERDYESLVLRKLRQAEERKRLTEQIMKEDQESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ALH0</accession>
    <name>A0A812ALH0_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7041 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_2596</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000073">
        <property type="protein sequence ID" value="CAE1149040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ALH0"/>
    <dbReference type="OrthoDB" id="6231004at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055469">
        <property type="entry name" value="DUF7041"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327">
        <property type="entry name" value="ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327:SF3">
        <property type="entry name" value="RNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23055">
        <property type="entry name" value="DUF7041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7041" evidence="2">
        <location>
            <begin position="24"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="210"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1149040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="276" mass="31107" checksum="6340C45754F03032" modified="2021-09-29" version="1">MADYAPPTQATFRIELPTYNTSVQTWFVQLGAIFQARYITSQQSKFAYVVEKLPADVASEVADILNDIPPDKPYEVLKQVILQRTACSEEHKIKELTNVTLGNNKPSQLLRKMQTLVGTNSMSEAVLKQMWLDKLSPDTVQILATLTDEVFIQKLAAIADKISDTRPTHLIASVALSSDSTPGTNQQLQTLASEVRKLSLRINEIQYIPSRSRSNSTNRNSVHRRRSTSRRPQHQPRSVCWYHEVFSARAKKCQPLCSYPSIFAPKQQGNDQPGNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AMK9</accession>
    <name>A0A812AMK9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_2200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000062">
        <property type="protein sequence ID" value="CAE1147727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AMK9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="346"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="381"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="408"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="438"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="496"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="522"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="551"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="591"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="628"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="667"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1147727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="695" mass="79751" checksum="AD873E1359955725" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AN01</accession>
    <name>A0A812AN01_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_3411</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000102">
        <property type="protein sequence ID" value="CAE1152415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AN01"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1152415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="157" mass="16849" checksum="33B37887FF4CC610" modified="2021-09-29" version="1">MLSVGVYSCPSCSCFTHRPPIDVRRVTIVCPPVGFPTYNCTLQIPVVVCRVAVVLPPSVGVKLCSCFTHRLAIDVRRVAAVSAVLSLDVHRVAVFTFPLNVDVRSVAVVSSVISVDVRRVAVVSSVISVDVRRVAVVSSVISVDVRHVTVLHPPVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AN03</accession>
    <name>A0A812AN03_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_2089</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000059">
        <property type="protein sequence ID" value="CAE1147382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AN03"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1147382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="262" mass="31871" checksum="BD2E0E3579E79BDC" modified="2021-09-29" version="1">MYISIYLSIYLSIYLSAYDFFISIYLFIYLSVNLFNARFVSFFFIFFFHHLFHLSFFLFRSFLFLFISSILVFISVFFLFVFLFVSLVLFLFLPFSFLLTFSFFSFSICFFHFSFYLFLFFLSLFLSMYLCFFYFSFLLSSSFLTFVSFSIILSFFIPFCLSFFFMPLFLFLFHFFNLLNRLSLLFLSLLFLIFLISLSFSLSFIFFDFFFISPSHIIFFLSFFLSFFLSFFLSFFLSFFCFSIISLALCLKPLHFPLHSYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AQ18</accession>
    <name>A0A812AQ18_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ubiquitin-conjugating enzyme E2 G2</fullName>
            <ecNumber evidence="2">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">E2 ubiquitin-conjugating enzyme G2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Ubiquitin carrier protein G2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Ubiquitin-protein ligase G2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SPHA_4570</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Farmed</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Involved in endoplasmic reticulum-associated degradation (ERAD). Required for sterol-induced ubiquitination of 3-hydroxy-3-methylglutaryl coenzyme A reductase and its subsequent proteasomal degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.23"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Interacts with AUP1 (via C-terminus); the interaction recruits UBE2G2 to lipid droplets. Interacts with ubiquitin ligases AMFR/gp78 and RNF139/TRC8; recruitment to lipid droplets by AUP1 facilitates interaction of UBE2G2 with AMFR and RNF139, leading to sterol-induced ubiquitination of 3-hydroxy-3-methylglutaryl coenzyme A reductase and its subsequent proteasomal degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="2"/>
    <dbReference type="EMBL" id="CAHIKZ030000146">
        <property type="protein sequence ID" value="CAE1155773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AQ18"/>
    <dbReference type="OrthoDB" id="19692at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23796">
        <property type="entry name" value="UBCc_UBE2G2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000008">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 G2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 14" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="15">
        <location>
            <begin position="46"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="13">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00055690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00063420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00073285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00076340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00079258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00079959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAE1155773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="207" mass="23232" checksum="52C4FCF8936237CF" modified="2021-09-29" version="1">MDEIIKTIIDIFFSLSLSLSLKDARALPFLQENFGGIDIFQDFFFFFSLSLSLSLVKLTLNPPEGIIAGPVSEENFFEWEALIMGPEGTCFEGGVFPARLMFPPDYPLSPPKMKFNSEIFHPNIYVDGRVCISILHAPGDDPMGYETSAERWSPVQSVEKILLSVVSMLAEPNDESAANVDAAKTWREDRQRFNDIARRTVEKSLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AS65</accession>
    <name>A0A812AS65_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_5761</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000189">
        <property type="protein sequence ID" value="CAE1158976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AS65"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1158976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="266" mass="31806" checksum="95E08B2E7C25A83C" modified="2021-09-29" version="1">MYLSQSVRIYLSIYLSIYLSIYLSIYLSIYLSPSFLHFSLLYIYLGLLSFLSIYLYIYLSSSIYSYLSIYLSVYLSIYLSISVYSYLSIYLSQFIHIYLSIYLYQFIHIYLSIYLSSYLSIYLNLFISIYLSIYLSLFISIYLSISIYSYLSIYLSIYINSFISIYLSIYLSIYLSIYLSSYLSIYLSIYLNLFISIYLSIYLSIYLSQFIHIYLSIYLSIYLSIYLSIVIRLFFLSHLILTYLFIFITHPRSILQKPLIMTKPIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ASI7</accession>
    <name>A0A812ASI7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_4648</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000149">
        <property type="protein sequence ID" value="CAE1156057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ASI7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1156057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="202" mass="24260" checksum="0BFCAF4BC19E5B89" modified="2021-09-29" version="1">MLMRFYSDSDDEPLFMLAVTNLYAYEDKFMDCTHVSCYYSLSLSLSLSLSLSLSLSEHHAEVYITLTLKISTLAGNGVYLYLIDNSLTSIFVLTILLFHPSLSYRYYLYFTDTYFSSIQLYLILLFHPSRFYRYFSFIHLYFIDTSLLIHLFFLLILVFHPSLFYRYSSFIYPYFIDTSLLIHLFFYRYFTFIYLYFIDTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ASX5</accession>
    <name>A0A812ASX5_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_4858</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000158">
        <property type="protein sequence ID" value="CAE1156604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ASX5"/>
    <dbReference type="OrthoDB" id="6088476at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF73">
        <property type="entry name" value="PROTEIN PDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="2">
        <location>
            <begin position="82"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1156604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="162" mass="18265" checksum="099EED46440E91EB" modified="2021-09-29" version="1">MSASQRKTLSISEQLELIDDVKVKKLKLAAAAKKYGIGYSTAAKILKKEDDLRSCMQMNGNTNRKRKRQSVHKDVNEALTQWFTQACAHGATVVNEALTQWFTQASVHGATVADHVIRQKASQLALNLEVDFEPSNGWLMRWKQANNVSFKKFTANQRRPCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AT28</accession>
    <name>A0A812AT28_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_3758</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000113">
        <property type="protein sequence ID" value="CAE1153160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AT28"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="297"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="401"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="441"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1153160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="466" mass="53997" checksum="0D57E040725C942A" modified="2021-09-29" version="1">MLAHKIFFLLARLYATSIAKIAVLLFSWLSFLLFLIFHFTVSVILTLCYSLCLSCFSDDLFTFFIFRHFLTHSHSLFSMFTYLLFRFPLLIYLIFFLSVSAMSLPLFISQWYISLSLSLSHTHTQWYLSHFHNGLFLSHSGISLFLFHSGISLSFTVGFLSLSLSQWYLFLSLSLSQWYFSLFLSVISFFLSLSLLFFLSLPLCAISPFLCHFTFSLFVISFSFISLFLSFFSFSFIFYLSLYFLSPSFCHFSLSIFLLFFSLSPSFCHFFSLSLFLSFFLSPPSFCHFSLSLPLSVIFSLSLSLFLSFFLSLSLFLSFFLSLLFLSFFLSLSPSFCHFFSLSLPLSVIFLSLSPSFCHFFLSLSPSFCHFSLSLFPFCHFSLSLPSFCHFFSLSPSFCHFFLSPLFLPFFPSFLSCHFPYFRCLSLSHFPLSRSVISLTFSLFLFISFLSFSFCHFSSLSVSLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AUJ0</accession>
    <name>A0A812AUJ0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_5409</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000180">
        <property type="protein sequence ID" value="CAE1157774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AUJ0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1157774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="233" mass="27830" checksum="BB08BF3B6A733C9F" modified="2021-09-29" version="1">MFIIYLFIYLSIYYLSHLSILFVYLSIHLSIIYLSIYLSFSLYLSMFINIHYYLYLSTHPLLSIYLSHLYHISFHYYLSIYLFLIYSFIYLSSIHLSIYPSIYLSIYLSQSFISLLSIYLSIYLSIYISHYFLFSSIYLSMLLMYLSIYLSFPHPWGIYLSIYLSEIIYLEVHSLDLFIISIYLFIHLIYLSIYLSFSLIYDSSIYLSIYLSLSISFPYLSIYLSISRAATSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AWE5</accession>
    <name>A0A812AWE5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ALPK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SPHA_6359</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000208">
        <property type="protein sequence ID" value="CAE1160277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AWE5"/>
    <dbReference type="OrthoDB" id="301415at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048029">
        <property type="term" value="F:monosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002753">
        <property type="term" value="P:cytoplasmic pattern recognition receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.200.10">
        <property type="entry name" value="MHCK/EF2 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004166">
        <property type="entry name" value="a-kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043529">
        <property type="entry name" value="ALPK1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46747">
        <property type="entry name" value="ALPHA-PROTEIN KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46747:SF1">
        <property type="entry name" value="ALPHA-PROTEIN KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02816">
        <property type="entry name" value="Alpha_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00811">
        <property type="entry name" value="Alpha_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51158">
        <property type="entry name" value="ALPHA_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Alpha-type protein kinase" evidence="4">
        <location>
            <begin position="1"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAE1160277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="232" mass="26578" checksum="7D32542D2962F5A7" modified="2021-09-29" version="1">MRNRLLNKFQRQESLTEEPLVNISRADDIYQESLSSFIGKLLQEHLKPNILSSETCFHLPISKLNVNSANQNETINKIQKATLYQYNPVTYVWSGQDTIVCTGKELTLGKGKKGSFRNVYQITFLHQDEPLGKYVSKRYRQQREPLQYMDDVVSQMQAGLYSGGKLMVSDLQGWLPSGTQNLIYLTDPQFHTDSGDSSPFDFGQDGMKVFFDVVHPECNEICKTLKLERPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AWQ0</accession>
    <name>A0A812AWQ0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_6690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000219">
        <property type="protein sequence ID" value="CAE1161068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AWQ0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1161068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="151" mass="17750" checksum="E6F2C6FBDC64B55E" modified="2021-09-29" version="1">MGLGELTVYLHLPFCQVSQESIYLSIYLSIYLSIYLSIYLSNYLSMSFTIYLLIYVAYYLCILISIHVLTIYLSIYLSIYLSIYLSVSLHIYLFLSLHIYLSIYLSIYLCLLISIYLSIYLSIYLSMSLIYLSIYLSIYLSIYLCLLLSIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AWS1</accession>
    <name>A0A812AWS1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_6562</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000214">
        <property type="protein sequence ID" value="CAE1160751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AWS1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1160751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="239" mass="28834" checksum="1A0D45D99D1C84BE" modified="2021-09-29" version="1">MILLRGHDNIEEKSASSHNIYFRLVSIYLSIYLSIYLSVPSFSFFLSFFLSFFLSFLRIYLSIYLSIYLSIYLSIYQVLSFFFSHSFFHSIVFSFPISFIFSITFFFFRTFFSLSFFFLSFFLSFFLSFFLSFAFVSLFLFWLFLSFAFTLSFSCFRFFSFFFFFFFFFFLFSFFLSFFLSFFLSFFLTSECFFSYMLLSLSLDIYLLFSLFLSLSLSTSIYLSSEKSKYRLSEFSDGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AZ46</accession>
    <name>A0A812AZ46_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_7424</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000238">
        <property type="protein sequence ID" value="CAE1162769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AZ46"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="279"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="341"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="371"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1162769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="406" mass="49894" checksum="50B4AAFBFC35A99F" modified="2021-09-29" version="1">MFSFNSFVLSILLFTVFFSFLILFFSFNFILPFSFSRSFFVLITFCSSIPYFSFFISVVLFLLLFFLLCFLKSYFSLSFIFRYIFFGCILIRYFLFFCIFPFVLFFFLLSFLFSFFLLSFLFFPSFLSFSSFFLTFFFFFFSFLSFFFFLLFIIFLFYFLFLCLFICYLSFFFSFFFSFFLSLIHSIFFEAFVLPLIYFHIITFFFFHSFYICISSFSFYHIFCNFLQHLYFDDFLFFLDIVLNPFLFYLLSFYFFLFFSFGLSAYFHRYSHSFAFVNSFFFFFICSPFYIFSFFYLIFYILLYPFLSTFLPLSVTLYFLSFFLSFFLSFFLSFFSFSLSLSLSLSLSFAHLVFFLIIFSDYFSHSCQLNLFFYLSCLFLKIFYSFSLCFILSFFLSFFLSFFLYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B1C6</accession>
    <name>A0A812B1C6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_8473</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000274">
        <property type="protein sequence ID" value="CAE1165471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B1C6"/>
    <dbReference type="OrthoDB" id="6241411at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1165471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="157" mass="17375" checksum="A5E042A7DF269DDD" modified="2021-09-29" version="1">MPSTVSPAGGPWEGRDPIGGKTALLRHLHGLLCLRWEKGHVRRHMRDANIVTLYKNKGDRSDCNNYRDISLLSVVGKVFARIVLPHLQSLASSSPCFSSTPSTTARWASTSALEEAANFTTSPDCALRPRSVRSSFVRCCLPTTLRLRPTRRTVCKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B1Z4</accession>
    <name>A0A812B1Z4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_8829</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000286">
        <property type="protein sequence ID" value="CAE1166329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B1Z4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="304"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="329"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="360"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="416"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1166329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="435" mass="50981" checksum="7331DBD80F668237" modified="2021-09-29" version="1">MLLHGSFFHRRAVASLCLFYKYFHVLRVSIYLSIYLSIYLSIYFWAHNLRLSSIHCVRIYLSHGLHIYLSIYLSIYLSIYLRDATASNFFFFRPATLLAKVRTLLSALFCLSGLQLFCLSGLQFFGLSGLQFCSNFSAAFEQFSSLRLGCNFSAYWLAGSYPRAPPSRPDSPFVSRFSIPEAHRRQQIPTHAHGQRTSDKFKSIYLSIYLSIYLSIYRSISICFYLSIYLSIYLSIYLSIYLSITICSYLSIYLSIYLSIYLSITICSYLSIYLSIYLSIYHNLFLSIYLSIYLSIYLSHSDRIYPSIYLIYLIYLISDRIYLSIYLSIYLSIYLSTQSIYLSIYLSIYLSIYLSHSDRIYLSIYLSIYLSIYLSIHPSHSDRIYLSIYLSIYLSHSDRIYLSIYLSIYLSIYQQSIYLSIYLSIYLSIYLSISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B2M7</accession>
    <name>A0A812B2M7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_9446</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000302">
        <property type="protein sequence ID" value="CAE1167463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B2M7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1167463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="254" mass="30076" checksum="2589626EB96E4EA5" modified="2021-09-29" version="1">MSHVTRRKHNDVIKTFFSFHSFNVSFSLSFSLSLSFHSVTVSFSFHLGICLSLSLSLSLSLSLSLSLFIHKFRATCFLRCRQSPFIFFYLFLSPSMVVHVKDEFLSSSLFFFFLLHFLSHFFFLFPSCFFIPSLYSLSFSLFLSFSFFTLLLAFSLLHFSLSFSLFLSFSFTLSFSLSLSFTFLFRSHFFFPFPLHLRSRFFIPPSFLFHPRFFFHSPLLLRCCFIFPSPFIPILKTYLFFFIFFFYVPCPFTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B2S0</accession>
    <name>A0A812B2S0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_8881</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000287">
        <property type="protein sequence ID" value="CAE1166385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B2S0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1166385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="407" mass="47313" checksum="5A0A4AC82265378E" modified="2021-09-29" version="1">MSFFLSFFLSFLFPYVFLSFFLSFFLSFFLSHLNFLSFFLSFFLSFFLSFFLSFFLSSFLSFFLSFFLSFFLLSFLSFFLSFFRIIFHYSFHLSFLSPLTINVILSVFLSFCLSFFIYFFLSFFLSLPLFVTLHFLSFFLSFFLSFFLSFYSYLCLFVCLYLSFFLSIPIFVCLFVCIFLSFFLSFFLSFFLSIPVFLSFFLSFYFCLVFFGPISYFIILIFPSSLSPSLSVSLSLSLCSLLSAFKLSPCLSLNFLVNIFLRSLYLTPINPPSLSYIPFLPSCTPFVCYNATTIQPSIYLFGCSPNHRTELLFMTAFTTDIDSVLTTPPQFPPAIQEENVILFPSAHFLNQTLTSVRKPSPCIHLEVPFLQKPLPEPLASCFFHCRVMHNIAPIIFLVTPVCLIFSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B5I3</accession>
    <name>A0A812B5I3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_11444</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000377">
        <property type="protein sequence ID" value="CAE1171133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B5I3"/>
    <dbReference type="OrthoDB" id="10039170at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1171133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="303" mass="34149" checksum="921F0EC28CB90150" modified="2021-09-29" version="1">MVGSSTSALSETSLDINSLQQIKEKIFSARECVSSESNKQRRTRNLLIQDRNEISDIHVRAENIVYFPHNRQHHYLNDVELSTEIFHDVDLRFGCPTKTSLLRSRQRAASTCVLSKQLKAQILKIQLKTPVFQKALSSERVRPASGVADNSYHGFLTGGRYNWAHLIDGKSRTDLGLYIPRSNPQRSFFVAKINKKEKKTIERVTLGCCTNKMQDTECQCCWPRQSLQPQPLSIQDASDNVPDLNMEEPGQAPPPTPVSVHPVAKSKKLTRVMTATAVHLKEKESNKQGLKEGGQNIWINTIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B6J8</accession>
    <name>A0A812B6J8_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase</fullName>
            <ecNumber evidence="4">1.1.1.179</ecNumber>
            <ecNumber evidence="3">1.3.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">D-xylose 1-dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">D-xylose-NADP dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Dimeric dihydrodiol dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SPHA_11649</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Farmed</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(1R,2R)-1,2-dihydrobenzene-1,2-diol + NADP(+) = catechol + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16729"/>
            <dbReference type="ChEBI" id="CHEBI:10702"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18135"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.3.1.20"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-xylose + NADP(+) = D-xylono-1,5-lactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22000"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15867"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.179"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.179" evidence="4"/>
    <dbReference type="EC" id="1.3.1.20" evidence="3"/>
    <dbReference type="EMBL" id="CAHIKZ030000385">
        <property type="protein sequence ID" value="CAE1171556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B6J8"/>
    <dbReference type="OrthoDB" id="2129491at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047837">
        <property type="term" value="F:D-xylose 1-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047115">
        <property type="term" value="F:trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050984">
        <property type="entry name" value="Gfo/Idh/MocA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604">
        <property type="entry name" value="OXIDOREDUCTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604:SF105">
        <property type="entry name" value="TRANS-1,2-DIHYDROBENZENE-1,2-DIOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="11">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="12">
        <location>
            <begin position="130"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00042988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAE1171556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="333" mass="37723" checksum="AF71A4F3EC8D1A1C" modified="2021-09-29" version="1">MKWGICGTGKICNDFCGALQLLNHDDHQITAVADRDIDSAQKFAEKFKIPKAFGCYEDFAREPTVDIVYIGVVSFEHCRLSIMMLNNGKHVLCEKPVTLNLKELEKVLKVAKDKQLFFMEALWSRFFPAYEKVRNAMDSKSLGEVRYVQAEFCLPVFNCEQVKKRELGGGGLLYIGIYAIQWALLAFKEKPDKIFAVGHLHETGVDQSATIIFKYKGGQMANLTYNTEIQSECTASICGTKGRIQLPYPFWAPTKVTINEEEMEFPLSSGEFKFNLVNSAGLSYEAECVRKCIEKGQLECPLFPHSESITIMTIMDEVRRQLGVKYDVDDIEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B745</accession>
    <name>A0A812B745_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_12696</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000424">
        <property type="protein sequence ID" value="CAE1173510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B745"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="302"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="385"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="410"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="442"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1173510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="466" mass="56737" checksum="E408D4BD86C9945B" modified="2021-09-29" version="1">MIRATHSDPLLSFFLSFFLSFFLSFSDIIQDMIHSEHFFLSFFLSFFLSFFLSFSDTFLLFFFSFMISFFLSFFLFLSFFLSFFLSLIPTSFFLFFLSFFLFFLSFLTTSFFLSFFLSFFLSFLSFLSNNTIRPLFFFFDLSFFLFFLSLDLLSLKLFFLFSFFLSFFLFFLSFFLNTIGLSIIPLDPFFFLSFFLFFLSFFFLSSVPALLHSNFFLSFLFFLSFFLSFFLTFLTFFLHTLTSFFLFFLSFFLSFFSFYFSFFLSKHYFSFRPFLSFFLSFFSFFSACFLHTLFFLSFFVSFFSFFLSFSVLSLHTLSFFLFFLSLSACFLPHPLTSFLSFFLPFFLSFFLSFFRHDPFYIPFFPLSFFSLTPFLSSSFFPFYDFYMLHISTFLSFLSFFYFFLSFFNLFSFFLSFLFFSFFLFFSSFFGSHRDIVMLTQTTFFLSFFFFYISFLSFLFLFFLSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B9K1</accession>
    <name>A0A812B9K1_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Transmembrane protein 106B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SPHA_13366</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM106 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000447">
        <property type="protein sequence ID" value="CAE1174963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B9K1"/>
    <dbReference type="OrthoDB" id="508875at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009790">
        <property type="entry name" value="TMEM106"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048509">
        <property type="entry name" value="TMEM106_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048511">
        <property type="entry name" value="TMEM106_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28556:SF4">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 106A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28556">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 106B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07092">
        <property type="entry name" value="TMEM106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21002">
        <property type="entry name" value="TMEM106_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Transmembrane protein 106 N-terminal" evidence="9">
        <location>
            <begin position="83"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Transmembrane protein 106 C-terminal" evidence="8">
        <location>
            <begin position="160"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAE1174963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="288" mass="32922" checksum="949DD4BE4A03157E" modified="2021-09-29" version="1">MQPTSNGRPNPRTQGYQTFENEGTSIQFCPEEIENLRNNSRQDIDKEPSESNTSPNRNQQTAVGSPEPSSFNNRYEELMKGEQCPTCRGLGRIPRHDAEQLVALIPVGDKRLKPRRTAQWVMLSVLVCSVIASLILFFLFPRNVRAISNQPYLEPLELNINVTSQYVFVSFVNRYNFSNENYVPVTVTGVTMAVQYDMRVLNKVVNTTNLIIPHLSLKEYYVAMNLTLSGDEGYLAKFCNDPRRWVHDMFMQFDLTANYSYLGHTEQTTLTTYQHVSCGNDTKSHSWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BAB4</accession>
    <name>A0A812BAB4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_12584</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000420">
        <property type="protein sequence ID" value="CAE1173363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BAB4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1173363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="217" mass="25473" checksum="5507A096883C39D8" modified="2021-09-29" version="1">MSLSLSLSLSSHSFTVACFPSFFLFCKLPDSIGFFFLSFFLSFLSFFLSFFLSCKLPNSIGLLYFFLFCSYQPLFILILFIYLSIYLSIYLSIYLSIYLSLFISIYLSIYLSIYLSIYLTCPFIAPLIPPLRARHFSITSTAYNSYFIFLSFFLSFFLSFFLSFLFSFFLSFFLCCVLFSFSSFFLSPLSFSSFFLTRGHFLCFNHCFFLLHRLHTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BAC8</accession>
    <name>A0A812BAC8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_13026</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000435">
        <property type="protein sequence ID" value="CAE1174277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BAC8"/>
    <dbReference type="OrthoDB" id="6161790at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1174277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="242" mass="28172" checksum="7D0E9E0350353396" modified="2021-09-29" version="1">MSVLFYLSIYLSIYLSIYLCLFFIYLSIYLSIYLCLFFIYLSIYLSIYLSIYLCLFFIYLSIYLSIYLSIYLNLFISGYLSIPVYSYLSLFPSIYLSIIHPSIYLSNYLSIHLSIYVCSLSIYLSIHLSISNLFISLSSIPVYSYLSLFPSIYLSIYLCLFFIYLSIYLSIYVCSLSIHPSIIHPSIHLSIYLSMSVLYPSIHPSIYLSIYPSIYLNLFTSGHPSIPVYSYLSLFPSIYLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BEH4</accession>
    <name>A0A812BEH4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_15198</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000527">
        <property type="protein sequence ID" value="CAE1178428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BEH4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="402"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="486"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="518"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="558"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="586"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="615"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="644"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1178428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="773" mass="91400" checksum="94C776A37990C5C7" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BEK7</accession>
    <name>A0A812BEK7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_16914</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
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    </organism>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000600">
        <property type="protein sequence ID" value="CAE1228693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BEK7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0472">Membrane</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="7"/>
            <end position="27"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1228693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="170" mass="20138" checksum="01A087C581D651CF" modified="2021-09-29" version="1">MRPFFFFCFLYTISFVNVLAFFFRLFFFSLPFIHSSTLSFFLSFFLSHFLSSPLSLFYASIHLSSNLSIFLPLFLSFTLHLLQSFILSVFITLGDMFSFIISGFFSSFFPFFFRWRTHASFVENFSHLFFSTVSSSPFFLLPLLFLFFLFFSICKFFSLYVDLSFALFIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BFV1</accession>
    <name>A0A812BFV1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_16568</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000585">
        <property type="protein sequence ID" value="CAE1227870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BFV1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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            <begin position="51"/>
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            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="262"/>
        </location>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="305"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="374"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1227870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="408" mass="45842" checksum="14889CCC25EE96F1" modified="2021-09-29" version="1">MAAVDIFVFVFTHFCFIIFCIFSVIIIIVSVRFLTFVIDLSYYPATVRRRLLLSLVLFCFTLSSLYPRGHVSHICSDDYLSIYLSIYLILHSLFQDFSVSLSPSLSLSLFVSLIDVSLYFSLCLYLCPFLRLYLSMCLFVSLRLCFCLYQSLCVSFSLSLSLSLSLSLCIYFYFYHDLYLSPSLPFFIFLTVSLSLSVSLCVTIHCLSQSLSLSIYLSIYLSIYLSIYVSLHLCISCRSLSLSLFVSVSSNYSLTLSLSLALSLSASISVPSSIILCLCLSLSLCLCVSASLSPSLSLSLSQVSLFVSPLLWLRLSHSVCVSLFLSVSFSLSESISVSVSLSLTVSISLCFYFYTDFHLFPYLSLSLSFTLKTLLNYLSIYLSIYLSIYLSIYSSLSIPIYNFFSSNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BJK2</accession>
    <name>A0A812BJK2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_17254</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000613">
        <property type="protein sequence ID" value="CAE1229355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BJK2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1229355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="278" mass="34087" checksum="647D9AADA14248AE" modified="2021-09-29" version="1">MRYHLIWLKFGLLHSFFLSYSLLSFFLSFFLPFFHSIFLISTYASNCRIRFSFFLSFLSIVFFFLSSFAENCANIFLSHLLICLKFGLFAFVLSIFRLFAFFFFHSFFHISSPHLLKIWLICFFSSSFRTSFLRLLKIWLIRFNSCIRFSSFFLSFFLSFFLSFFLENPPDFFCFLFLTSSSFSFFFLSFQVFYSFFFKYPFSFFPLIFLSLVNRLSADAYYISLNHFFLFYLLRLSFFLSFFIYLFIYLFIYFLLSFRTCYLLFYLDFFLIRFLSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BKU0</accession>
    <name>A0A812BKU0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_19415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000705">
        <property type="protein sequence ID" value="CAE1234640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BKU0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1234640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="221" mass="25419" checksum="2B775C4E68505E47" modified="2021-09-29" version="1">MISLSLPSDSFSFLYLSLFIISSLSLVFFRSLSLSLSLFFFYCTLFSIFILSFPSFFSIYKICLSLFNFFLSFFLSFFLLSVFSLTLSLLSLFPFLVTPTFFSLSLFLPFSLSLSSNFHPAPILSLDCRLYVPFFHISFTYYLFLAVFHSLPLSPLLKDVYSQFQSILFLYIYLSIYLSILSICLSLPISIYLCLYISIYLSIYLLSVCLSTDCSLSEIPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BLR6</accession>
    <name>A0A812BLR6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_21194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000779">
        <property type="protein sequence ID" value="CAE1238198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BLR6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1238198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="166" mass="20857" checksum="8F5AA6BBC4AB0926" modified="2021-09-29" version="1">MLLSILLLSSFTLFLNLTFFLFSFFLFLFFSSFSFSFSFLFLFSFFVPYFLSFFFYFSFFIFFLFYFFSFFFSFIVIFWVFFCSFIFFFIFSLNFSFFLFFFLPFFLFCFFSLFPPYFLLSFFHFALLFLSFKFFSFLYLSLFFFVLFSFSFFTRFFFLSFSLNSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BRK8</accession>
    <name>A0A812BRK8_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SEA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SPHA_20887</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000766">
        <property type="protein sequence ID" value="CAE1237692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BRK8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000082">
        <property type="entry name" value="SEA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46662">
        <property type="entry name" value="DI-GLUCOSE BINDING PROTEIN WITH LEUCINE-RICH REPEAT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46662:SF104">
        <property type="entry name" value="GPI-ANCHORED ADHESIN-LIKE PROTEIN PGA55-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50024">
        <property type="entry name" value="SEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="454"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="521"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="826"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="854"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="884"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="910"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="935"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="962"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="997"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1025"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="domain" description="SEA" evidence="3">
        <location>
            <begin position="1052"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1061"/>
            <end position="1098"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAE1237692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1098" mass="128155" checksum="6552953558F10C88" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BS58</accession>
    <name>A0A812BS58_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_25877</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000985">
        <property type="protein sequence ID" value="CAE1247863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BS58"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1247863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="391" mass="44373" checksum="DCEA05AE7D945DBB" modified="2021-09-29" version="1">MPLKIFSGKFLQDVNDEDSTEILFSSSPSENLDTRFCVLISTSSPLYLSRTHTQNSIFSIPPISDFLSFPFSLPSFAPSHFRFSPSYYHSHVLPLANSFLSLLLHHTHSLDVCLSIYLSLTLRNTHSLSLSLFFYSIIHSHSRRVYASHPHTTLFSFLSLSLPISIFLSFPLSIQPSFPHFPFSASCHLTPFLCSHSPLISFFSLLLHYTLSLSICQSLSLSHTQTHNFPFSFFRYFLTFSLSLHPFANSLFLPLSSSLSTHPSSSSSRFFSIPYCVCLPVSPSVCPSLSLSLIHTQYFPFSRYLYVFSHFLPFISPHLFVPSLFLPLSLSLIFYPLLHLFISFHSNLLHHPLTLTSSSLFTFVLPHSPYFPLLPTLSRSMHSFNPHLLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BSR4</accession>
    <name>A0A812BSR4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_22901</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000846">
        <property type="protein sequence ID" value="CAE1241543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BSR4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1241543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="230" mass="28177" checksum="E28D3368E50DAF49" modified="2021-09-29" version="1">MYFIFFYYYYFFVLLFITFSLFSFLPPFFFISLLFFLFFSYLVFPFLFNNFRFTPFHLMFIMFLLPSFLPSFLPSFLPSFLPSVLSFFLLFSHFLIFSDFFVNSFFLSSFFSSLLSSFLPFFSYFPQSKISLRPFSSYSFFYSFFYFYPLNLFFPCKHSLFNLSLSFIFSYLFIVFFPFLFNNFCFIPFHLMFIVFSFLSFFLSFFLSFFLSFFLVLSHFHNFSCLHLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BV28</accession>
    <name>A0A812BV28_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_27473</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001068">
        <property type="protein sequence ID" value="CAE1251333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BV28"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1251333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="217" mass="24916" checksum="48AAFF757F4EDE1F" modified="2021-09-29" version="1">MILSFFLSFFPFLSFFQSSHLSFILSFFLSFFLSFFHSFFFLSFSFNLLIFLSFFFLSFFHSSHLFSFFLSFFCSPYPALSLLLSLDLPLQISLLLFLIPFHLYPSSSLSLSFFAKSSELLRCHTSIIYSDNKRGMHRFFSARLFSSTSPENIRDSFAFVAINISILMQTFPICLCLSPMALPVILLHNSLSLSLSLSAPPHTHSFVFLSLPDCQAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BYJ2</accession>
    <name>A0A812BYJ2_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Exostosin-2</fullName>
            <ecNumber evidence="6">2.4.1.224</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">SPHA_26458</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">Farmed</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the glycosyltransferase 47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.224" evidence="6"/>
    <dbReference type="EMBL" id="CAHIKZ030001012">
        <property type="protein sequence ID" value="CAE1249180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BYJ2"/>
    <dbReference type="OrthoDB" id="5954868at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050508">
        <property type="term" value="F:glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015012">
        <property type="term" value="P:heparan sulfate proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000035">
        <property type="entry name" value="Putative Exostosin-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004263">
        <property type="entry name" value="Exostosin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040911">
        <property type="entry name" value="Exostosin_GT47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015338">
        <property type="entry name" value="GT64_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48261">
        <property type="entry name" value="ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48261:SF5">
        <property type="entry name" value="EXOSTOSIN GLYCOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03016">
        <property type="entry name" value="Exostosin_GT47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09258">
        <property type="entry name" value="Glyco_transf_64"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 22" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="14" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="18" id="KW-0464">Manganese</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="8 22" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Exostosin GT47" evidence="20">
        <location>
            <begin position="24"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase 64" evidence="21">
        <location>
            <begin position="326"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00069568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF03016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF09258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="CAE1249180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="586" mass="67822" checksum="FB2EEBE5FC8AE0B8" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C0I2</accession>
    <name>A0A812C0I2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="14">ATL</fullName>
            <ecNumber evidence="14">3.6.5.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SPHA_30249</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Farmed</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="14"/>
    <dbReference type="EMBL" id="CAHIKZ030001214">
        <property type="protein sequence ID" value="CAE1256560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C0I2"/>
    <dbReference type="OrthoDB" id="7788754at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01851">
        <property type="entry name" value="GBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003207">
        <property type="entry name" value="ATLastiN (Endoplasmic reticulum GTPase) related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:004169">
        <property type="entry name" value="Atlastin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.420:FF:000001">
        <property type="entry name" value="Atlastin-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.420">
        <property type="entry name" value="AHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030386">
        <property type="entry name" value="G_GB1_RHD3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003191">
        <property type="entry name" value="Guanylate-bd/ATL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036543">
        <property type="entry name" value="Guanylate-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015894">
        <property type="entry name" value="Guanylate-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10751">
        <property type="entry name" value="GUANYLATE BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02263">
        <property type="entry name" value="GBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02841">
        <property type="entry name" value="GBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48340">
        <property type="entry name" value="Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51715">
        <property type="entry name" value="G_GB1_RHD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="422"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="447"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="GB1/RHD3-type G" evidence="13">
        <location>
            <begin position="36"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAE1256560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="516" mass="59090" checksum="4F89BADEFAC9843B" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C0Z5</accession>
    <name>A0A812C0Z5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_27408</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001062">
        <property type="protein sequence ID" value="CAE1251154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C0Z5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1251154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="165" mass="18112" checksum="B42C3411526EC0A6" modified="2021-09-29" version="1">MSELAEDAPADSALIKQLFFSMLPQNVKAILAPMVEISSAHHLATSADRIVDILKQPAFSATLQPQAEFSSFSPASAHDTIQSLVILQALERLTKELGDMRGRRLIDVNTALKSTVPSISPLVFIAASDDPFQALLAFFPEFCGEQTYSIHKTSYRDHWSACVFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C1F8</accession>
    <name>A0A812C1F8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_27883</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001094">
        <property type="protein sequence ID" value="CAE1252228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C1F8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1252228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="215" mass="25680" checksum="7877FA9C3F7C22BA" modified="2021-09-29" version="1">MSFGVLRSLCLKDKIFVFLNIFSPFLLSIYLSIYLSIYLSIYLSMFIFIYLSFLFLHSSEKVATEAYHILSICLSIYLSQFVHIYLSIYLSIYLSIYLSLFISIYLSIYLSIYLCQYIHIYLSIYLSIYLSIYLSIYVSIFRAIYLSILHSSLCFFLSFFLSFFLVSFFLPSFLSLFLYFFHSFLFFFIYSILFLFPSFLSFFFLSSFLPLFLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C2H4</accession>
    <name>A0A812C2H4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_28648</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001122">
        <property type="protein sequence ID" value="CAE1253860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C2H4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="322"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="366"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="393"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="425"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="495"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="531"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="615"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="659"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="692"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="727"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="765"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="804"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="846"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="893"/>
            <end position="916"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1253860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="918" mass="107472" checksum="FA650554CA2DD21C" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C4Z4</accession>
    <name>A0A812C4Z4_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SPHA_28283</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Farmed</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001112">
        <property type="protein sequence ID" value="CAE1253279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C4Z4"/>
    <dbReference type="OrthoDB" id="1875589at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23702">
        <property type="entry name" value="eL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039660">
        <property type="entry name" value="Ribosomal_eL14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002784">
        <property type="entry name" value="Ribosomal_eL14_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11127">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11127:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01929">
        <property type="entry name" value="Ribosomal_L14e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL14" evidence="7">
        <location>
            <begin position="50"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="135"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="150"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAE1253279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="188" mass="21406" checksum="ECF52B0E95C7F63E" modified="2021-09-29" version="1">MVFNKKFVEIGRVAYIVSGPFSGRLCAIIDIIDQNKALVVGPVTGVPLLAINFKSLHLTRFVLNFRHSAKSHEVKTAWERKAINRRWAQSQWAKKIECRKKKAKMTDFDRYKLMRAKQSRNKIIRLEVGKLRKKPLRDVLPKTSPPKPKAVYKPRPKSKKLVITKGKDTKGKAASTTEVKSKKSVAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C5G4</accession>
    <name>A0A812C5G4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_30471</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001224">
        <property type="protein sequence ID" value="CAE1256818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C5G4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1256818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="173" mass="21037" checksum="D1015ED96BA16735" modified="2021-09-29" version="1">MSFCFSFFFSFFLSFFFTFCLFNLLFLPFSFFFFPLSFFLSFFDNSSFLFLSFFLSFFLSFFLSLFFLFSFFLIFFFLFLSIFTLILFISFLSFFFIFSLFFLSFFISFLFLILSLFFLSFFFSSSYFFLLLNRHLPHTKKEIFIIICSKPEAPDTKKIPADFCRLADDVTTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C7U4</accession>
    <name>A0A812C7U4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_29297</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001165">
        <property type="protein sequence ID" value="CAE1255032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C7U4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1255032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="399" mass="42324" checksum="1F4E23F4EC877CA4" modified="2021-09-29" version="1">MLAANPSKRHTAVQITTCFNCQIASNILRTPASPGIIKRIDRLPLSSPAPSYPSHPLHPLTYVASCTLLPLSPPAPSYLCHLLHPLTSLTLCTLLPLSPSAPSYLCRLLHPLTSLTPCTLLPLSPPASSYLPYPLHPFTSVASCTLLSLSPPAPLSSPAPSHFSHPCTLLPRSPPAPSYLSHPLHPLTSVTSCTLLPLTPPAPSCLCHLLHPLTSLTLCTLLPLSPPAPSYLSHPLHPLTSFNPCTLLPLSPPAPSHLFQPLHPLTSVASCTLLPLSPPAPSYLSSCTLLPLLPPAPSYLSPLHPLTSLIPCTLLPLSPPAPSYLSHLLHPLTSLTLCTLLPLSPPAPSYLSHPLHPLNSFNPCTLLPLSPPAPSYLSHPLHPLTSLTSSHINPKKNSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C7Z7</accession>
    <name>A0A812C7Z7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_30099</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001209">
        <property type="protein sequence ID" value="CAE1256307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C7Z7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1256307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="152" mass="17453" checksum="C390993356C3187E" modified="2021-09-29" version="1">MSRSHPIYLSIYLSIYLSIYLSGLIYLSIYLSIYLSIYLSMSVCLQSHLSIYLSIYLDNLFTILSINQSIPISLSSHLSIYLSIYLSIYLSIYLSMYLSIYLSIYLISLHLSIYLSIYLSIYLSRSFSPSIFLSLSLSLERTKPPHSTGFVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C879</accession>
    <name>A0A812C879_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_34462</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001462">
        <property type="protein sequence ID" value="CAE1264996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C879"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1264996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="234" mass="26962" checksum="BEAD5BCBAFB18BF7" modified="2021-09-29" version="1">MTLFSLFLSLSFLSLSLLSLSLSIYLSISIYLYIYIYIYIYIYIYIYIHIYILSLTPLYLSNFSLSQSQSLSLSLSISLSIPLAIPVYSYLYDILSLFLTPLFSLSLSLSLSLSLLHSEEFLCTHSLSIYLSIYLSIYLSIYLSICFSLSIYLSIYLSIYLSISAIPYNISTDLSIYLSIYLSIYLSICFNLSQPVHIIYLSIYLSIYLSIYFRSLKSLSIYLSIYVDVYEGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CBC2</accession>
    <name>A0A812CBC2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_31703</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001308">
        <property type="protein sequence ID" value="CAE1259450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CBC2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1259450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="251" mass="29546" checksum="EAF8D2591C18F165" modified="2021-09-29" version="1">MNKVPKIHSFLILFLIDNSTKHFYSFQHYFLFLSLFSFLSFLSFFLSFFLSHSFIPFFSFFLFLFSFPCFLFSAFFPLFFLFLFHSFIISFYLFFFALPCEPLLLAWHLSSFESCKSWSHAGLEFSEFLTVRESFLSLGLSVNLSLSLFSRRKRMSLFFRSLLSSPLSVSLSLSLSISKSSSSMLEVLQMLFSQLFLSLNIFFLFVLMSIFSISFLFLLLCLFLDFCLRSFPRNGHIKSIYLSIYLSIYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CC75</accession>
    <name>A0A812CC75_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_36681</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001613">
        <property type="protein sequence ID" value="CAE1269663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CC75"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="310"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="372"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="401"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1269663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="463" mass="56095" checksum="4013F30EA9458345" modified="2021-09-29" version="1">MKIGGKKLTCVKLILPLSLSLSLSLFFRHFPVFSSFLFCFSHFLPPFLVCSSLSFYLSHSLHLFPVNSYFFYRYYFLFFPFTSFYIGLSFLSLFLVFFSSFLLSFLLTSDHSCSLFFFSFCLLLPFSALSCFLFNHLSFSLFSYFLVFSSFFTFIFSLSLFRSLLSFLLFPFSLFFLFSCHFFFFSLRLFSAIFSFTFVLFIPFCIYSFRLFIFISLIYFFFILLLQLFDFLLIIFLFLCLFASLIIYSFTLLFFSVFSFSFASQHHLLLFLFLILILFPVDIGLLLHMFAYSQLLHLIYSFLSLFIFHFIYFCSFFFFFFFFFFFFFFFFLFNIFFFQFKFTRFLIYLVTFIFSFLNVDFFSFFHVHRYNFSGYMFYFLSFSTLFSFFVYSSFSFFHSFVFFFIFPFISILFSISFLFFFLFFFLLSFPTLYHSSFISSFPASYSPQLPFSLYFNLPLDIFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CDU2</accession>
    <name>A0A812CDU2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PPP1R2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_33390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein phosphatase inhibitor 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001398">
        <property type="protein sequence ID" value="CAE1262797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CDU2"/>
    <dbReference type="OrthoDB" id="551302at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004864">
        <property type="term" value="F:protein phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1050">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007062">
        <property type="entry name" value="PPI-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12398:SF20">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY INHIBITOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12398">
        <property type="entry name" value="PROTEIN PHOSPHATASE INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04979">
        <property type="entry name" value="IPP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="42"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="100"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="115"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1262797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="230" mass="26336" checksum="E24ED5C3AD094F99" modified="2021-09-29" version="1">MATDEKRPKKGILKNSSSFDKPENSSRKEMKWDEMNILATHHPADKDYGHMKVDEPPTPYARLSDQEDDDDVEDGDIPNRKHLKKKQSLEELDGLNPEDLAERLRDPKSAKVFDSQDDDEEEESEEETEEMRAKRKVFEKKRKLHYNEFQAVQIAKQLMQLEEDDSEEDNTETNNIAETPHHPPSLSLSLSLSLSLSLSKVICDFICCCCLGFFFSLTSLSLSLSLSSPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CGQ2</accession>
    <name>A0A812CGQ2_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Arsenite methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.137</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SPHA_34403</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Farmed</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>arsenic triglutathione + 2 [thioredoxin]-dithiol + 2 S-adenosyl-L-methionine + H2O = dimethylarsinous acid + 2 [thioredoxin]-disulfide + 3 glutathione + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:69464"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:23808"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:183640"/>
            <dbReference type="EC" id="2.1.1.137"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>arsenic triglutathione + 3 [thioredoxin]-dithiol + 3 S-adenosyl-L-methionine = trimethylarsine + 3 [thioredoxin]-disulfide + 3 glutathione + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:69432"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:27130"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:183640"/>
            <dbReference type="EC" id="2.1.1.137"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>arsenic triglutathione + [thioredoxin]-dithiol + S-adenosyl-L-methionine + 2 H2O = methylarsonous acid + [thioredoxin]-disulfide + 3 glutathione + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69460"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17826"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:183640"/>
            <dbReference type="EC" id="2.1.1.137"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. Arsenite methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.137" evidence="2"/>
    <dbReference type="EMBL" id="CAHIKZ030001458">
        <property type="protein sequence ID" value="CAE1264884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CGQ2"/>
    <dbReference type="OrthoDB" id="8300214at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030791">
        <property type="term" value="F:arsenite methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018872">
        <property type="term" value="P:arsonoacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009404">
        <property type="term" value="P:toxin metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026669">
        <property type="entry name" value="Arsenite_MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43675">
        <property type="entry name" value="ARSENITE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43675:SF7">
        <property type="entry name" value="ARSENITE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="7">
        <location>
            <begin position="88"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00034521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00034545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAE1264884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="379" mass="42980" checksum="C1BC470B47457263" modified="2021-09-29" version="1">MSVSAVSEISKDTNSWNVKRKNAKRVYAEVEDYYGKKLKKSEDVKIVNCSVKAGTACTKLIKEALSSVHPEVSSRYYGCGLTIPTKLSGKKVLDLGSGSGRDCYAISKLVGETGQVIGVDMTESQLSLARSYIDYHMKEYGYKTPNISFVKGYLENLTDAGLKEDFFDVIVSNCTVCLSPDKRKLLTEAYKVLKFGGEMYFSDLYADKVVPETLHDNAEMWGEGMTSALVWTDFYKIAKEVGFTQPCLVSISPLPICDKKYREALEDIHYVSATYRMFKLPTDEEKLNFTYKGTVPENEDQLLFDHRTVFKCHEKKCNDFKMAAILKNSRYSEDFDFEDCSNLDEHEAVCYKPVNPFEYLAQLKSENRMPSPPPCSKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CHU8</accession>
    <name>A0A812CHU8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_34990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001502">
        <property type="protein sequence ID" value="CAE1266039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CHU8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="304"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="335"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1266039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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</entry>
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            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001722">
        <property type="protein sequence ID" value="CAE1273282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CM31"/>
    <dbReference type="OrthoDB" id="5593012at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.100">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042222">
        <property type="entry name" value="Dynein_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703">
        <property type="entry name" value="DYNEIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703:SF1">
        <property type="entry name" value="DYNEINS HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08393">
        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein heavy chain linker" evidence="3">
        <location>
            <begin position="180"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="250"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAE1273282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="387" mass="45081" checksum="A34B01EAF88E9FD7" modified="2021-09-29" version="1">MSVDNSECPSPPKLHRLLPSLPPLPSTVKEPSTLYQIVVKNGTHPPIMDDMSWTLASPFKEQKHSVKPSDSIVNDDYEFSLRKAIVDYILKDPKEKARLHIAWIPQSFPQRVIRSPVPWHFTYIQMKEFNKQCLFYFLKFLEIHIKIDSYQDLMNEIALLYITVPLSMFCLDSTELNESLHNKANNLKQRIISFEVDENRRINKSICKRYDEISDKVSIIPTTTKELVETQAFLQQIMSSDEMKANVEHLDYLHKNLEAAQNELDDINTQEQLLGLEEIGVAAAKEYSLEKALSKMKSEWKDMYFEMVPYRETGISILSGIDDIQLLLDDHIVKAQTMKGSPFIKPFENEMKDWEEKLVSMFDIIEEWLKALTHHIHFLLCSLIHHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CPF2</accession>
    <name>A0A812CPF2_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SPHA_40963</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001952">
        <property type="protein sequence ID" value="CAE1277981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CPF2"/>
    <dbReference type="OrthoDB" id="6414306at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF49">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21549">
        <property type="entry name" value="PRDM2_PR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="220"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAE1277981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="524" mass="58103" checksum="66FB6EF51AFF9D2C" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CPY3</accession>
    <name>A0A812CPY3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_39967</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001879">
        <property type="protein sequence ID" value="CAE1276391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CPY3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1276391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="192" mass="22474" checksum="CEFE04D5752E7B4A" modified="2021-09-29" version="1">MLSAKYLKEEALNVNLFISIYLSIYLSIYLSITLFADLSMCVSTSIYLSIYLSIYLSIYHAVCRSIYLCEDIYLSIYLSIYLSIYLSRCFQIYLFEHIYLSIYLSIYLSIYLSIYHAVFRSICLSTSIYLSIYLSIYHAVFRSICLSTSIYLSIYLSITLFSDLSICLSTSIYLCRFQIYLAIHLSFKIFRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CQE0</accession>
    <name>A0A812CQE0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_40292</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001902">
        <property type="protein sequence ID" value="CAE1276811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CQE0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1276811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="242" mass="29658" checksum="D1AA62D786E3CEC9" modified="2021-09-29" version="1">MFVSFFLFRMFLSLFLSFFLSFFLSFFLFLIFLFFFSEYFFLSFFLSFFLFRIFLSFFLSFPNISFFLFRIFLFFFLSFFLSFFLSFFLSFPNISFFLSFFSEYFFLSFFLLRIFLSFFLSFFLSFPNISFIFSFFLSFCLSFFLSFSFRSSFIYLSIYLSIYLSIYLSISFLSFFFFISICVFSFDLVHFFLSKNYPFFLFSVIIYSSFFLSCFYLVLLFYTHKCSFLFFSSFLPASSVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CQK6</accession>
    <name>A0A812CQK6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_41684</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002013">
        <property type="protein sequence ID" value="CAE1279240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CQK6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1279240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="255" mass="29481" checksum="78E373A4F8CCCED6" modified="2021-09-29" version="1">MIYPQGIISLSLSLSLTIFLFIFSIYIAYFFFFTFFFLSQLSLSQFSLSLFTFLFSLNCHYHNSLPLFFTFFFSLNFHYHNSLSRFFYFSFLSQMSLLQFSLSLFYSPFLSELSLSQFSLSLSLLISFSFSTDTITILSLSLSLFYFPFLSQLSLSQFSLSFLLSFSLSTVTITILSLSFFYFPFLSQLSLPQFSLSLSLLISFSLSTVTITILSLSLFYFPFLSQMSLSQFSLSLFYFTFLSQLSLSQFSASLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CRV5</accession>
    <name>A0A812CRV5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_42248</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002057">
        <property type="protein sequence ID" value="CAE1280330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CRV5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1280330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="292" mass="33436" checksum="B4EB90674C235513" modified="2021-09-29" version="1">MLSDACSSFVFLFVNDVCKYKALSSFYILFLFLSSSISFSSLLLFISQSCFLFMIFYSLFFISLDLFSTLSYSFFSFIIFIKHFLYVGFVSLYFHLFLFLSFVFLSLVFLSFSYFSNLLCILCLHHYNDRIFSFYHCPPLSLSPSLPCFIFLFSTLTKIHFPAILPCFSLCIITPSFNFSHVFTFLLSPYLQNSRNNLSYSLSLSLSLSLSLFLSLSLSISFALSLSLSLPPSLSLPLHSLCLHLFLCHLLSFCLLLSLCFLLSLCLSLQNVQADAIAKHTRVTEFRSNHSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CUM5</accession>
    <name>A0A812CUM5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_40922</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001946">
        <property type="protein sequence ID" value="CAE1277845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CUM5"/>
    <dbReference type="OrthoDB" id="10322434at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="578"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="589"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1277845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="604" mass="67699" checksum="ED0136F7F4DD9D88" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CW62</accession>
    <name>A0A812CW62_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_41691</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002013">
        <property type="protein sequence ID" value="CAE1279197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CW62"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1279197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="188" mass="22491" checksum="C466389F1EDBED23" modified="2021-09-29" version="1">MPKRFVPYVYFIDIMNICRKGILFGIISECSSLEATDFHSVLVSLRCSFVFNTLVVSIACFFSFFSKLLLLSYFRSFFLLFIHFFLFFLFLFLSFFVSFFFCFFLSSILSFFLSFVLSFFRSFFLSFVLSFFLSFFNTILLSPFLSFFSLFLSFFLSLILFFLPSFLVTYKPFLSFFFLSFFLSFFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CZ92</accession>
    <name>A0A812CZ92_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_42460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002082">
        <property type="protein sequence ID" value="CAE1280686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CZ92"/>
    <dbReference type="OrthoDB" id="7468475at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1280686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="329" mass="37750" checksum="862830D3DF1BA428" modified="2021-09-29" version="1">MSIMNVEDDGSLFQALLIMSTVNDEDDGRAFQALFDMSIMNEEDDGRIFQALLIMFIMNEAEDGRVFQTLLIMSNMNEEDDGRVFQALLIMSNMNEEDDGRILQTPFIMSIINEEDDGGSFQALFDMSIVNEEVDGRVLQALLIMSIMNEEDDGSVFQAVFIMSIMNEEDDGIIFEALFNMSILNKEDDVRAFQGLFNMSIMKEEDESRVFQALLIMSIMNEEDDGRVFQGLFNMTIMNEEDDGTVFQALFTMSIMNEEDDGTVFQALFNVFMNEEDDCRVFQALFNMSIMNEQEVGRSFQPLFKMSIMNKEDDDRVFQALFTMSITTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CZF2</accession>
    <name>A0A812CZF2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RLBP1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_47396</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002560">
        <property type="protein sequence ID" value="CAE1288937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CZF2"/>
    <dbReference type="OrthoDB" id="75724at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902936">
        <property type="term" value="F:phosphatidylinositol bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.20">
        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174">
        <property type="entry name" value="ALPHA-TOCOPHEROL TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174:SF200">
        <property type="entry name" value="RETINALDEHYDE-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00180">
        <property type="entry name" value="CRETINALDHBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="50"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1288937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="228" mass="27113" checksum="CFE1134D2BBFE612" modified="2021-09-29" version="1">MFNKKDDDYLMRFLRARKFDVKKTYTLMKGHVKFHNNYPQLTSKLTLDSVRSCLENGYPCLLPVRDKQGRVTFLFSIENWDMTEFPFHVIMRSYLYLLERLMISEKSQITGCVLIENFHNYSLKQALGLRPSELRMFVDILQGSFPARFKGVHFVHQPWYFSWTYAMVKPFLKRKLTKKVFIHGYNLENFWENFDMESIPKELGGSGASYDSQELIKALERLEKQENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D0I9</accession>
    <name>A0A812D0I9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_43622</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002201">
        <property type="protein sequence ID" value="CAE1282716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D0I9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1282716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="180" mass="20807" checksum="7D2F4783015EB61F" modified="2021-09-29" version="1">MSPSSEQHIHLDRFFHSIFPPEILSTSSGQKLFTPLSLHYPLSAHKPRPVSRILIRSLVSSIDHKTTVPCHLVFHFPSLYFDPKTRRQNLSIYLSISLSIYLSIYLSIYLFVCLPVCLYICLGLLFISPFQSVHYLSIYLSIYLSLLLSSFSSVPIFDESLWDSPSFRMRVKMFSFSECE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D147</accession>
    <name>A0A812D147_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_43356</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002171">
        <property type="protein sequence ID" value="CAE1282282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D147"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1282282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="210" mass="24690" checksum="A9D797689E935A64" modified="2021-09-29" version="1">MCVKALNCTIDRWFLYINRAGGQGLSIYIYLSIYLTVYLTVYLTYLLISIYLRFHIYLNLFISIYLSIYLSIYLSVYLSLSLSNCLSNCLSNLSVDIYLSQFSYLSLFVRIYLSIYLSIYLSIYLYVSPQIYLLVSRWLFISIYLAIFISIYLNFFIIYRSIYLSISVFSNLSACLSLSIHIYLSIYLSIYLSIYLSLFIYFSLSLPTMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D502</accession>
    <name>A0A812D502_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_47621</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002595">
        <property type="protein sequence ID" value="CAE1289354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D502"/>
    <dbReference type="OrthoDB" id="6161790at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1289354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="256" mass="29896" checksum="001CB63AA3E7BCF4" modified="2021-09-29" version="1">MSSEKIFFQNNNNQYISFFFLAIYLSIYLSQPVHTYISILVCSYLSIHLSIYLSISACSYLYIYLSLFTSNHLSIYLSLFTSIYLSQFVHIHPSIYLSISVCPHSFIYPWYLSISIHLSISACSYSSIYLSLFTFISIYPSEKSIYLSLFISSIYVYLSIYHLSIYLSLFIPRNLSQFVHIYLNLCLSIYIYLSIYYLSITACSYHLSIYLLSISACVYLSIYLSIYLSIYLSLRENISLFVPISFHIYKIYSTPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D6E3</accession>
    <name>A0A812D6E3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_48229</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002666">
        <property type="protein sequence ID" value="CAE1290501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D6E3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1290501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="291" mass="35488" checksum="D881AA11FDA1B3E5" modified="2021-09-29" version="1">MRFLRPISILLRSIYVFFVIYAFSSSYIHSSSFYIRFLCYICVFFVLYPFFFVLYPFSLLYMRFLRPISILLRSISVFFVIYAFSSSYIHSSSFYIRFLCYIFLRPISILLRSISVLLYMRFLRPISILLRSISVFFVIYAFSSSYIHSSSFYIRFLCYICVFFVLYPFFFVLYPFSLLYMRFLRPISILLRSISVFFVIYAFSSYIHSSSFYIRFLCYICVFFVLYPFFFVLYPFFSFYVFSLFYIRFLRSISVYFVLYPSSSLEIRFLRSIPVSFVLYVLFKIIQYEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D6U0</accession>
    <name>A0A812D6U0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_48488</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002702">
        <property type="protein sequence ID" value="CAE1290936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D6U0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="84"/>
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            <end position="122"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="162"/>
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    <evidence type="ECO:0000256" key="1">
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAE1290936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="216" mass="24501" checksum="E996B30501841D4C" modified="2021-09-29" version="1">MDFVAEVTNYQWTQVTPALEAAHLLAFLFLSLLLYLPPMSSLSLPFSVFLPFSSPSPSTLSNQIIAFPSLFLPISSFLLVSLTFQPHHLPHAMRLSLLSLFLFPPLSSSCLNPAYASFSFFSSPYLILFSSYHFLSTNLSPLLPYFVFPSVHLSLLFLYFLLSTQLSLHSSLFSLCRPLFFSHLFLFSSLCLNQFSPSLFPLPDIRNRVWRPSDKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
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    <name>A0A812D7V3_ACAPH</name>
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                <person name="Bekaert M."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">Farmed</strain>
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    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <source>
            <dbReference type="EMBL" id="CAE1294261.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DA92</accession>
    <name>A0A812DA92_ACAPH</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
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            <taxon>Sepiida</taxon>
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                <person name="Bekaert M."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_53234</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003379">
        <property type="protein sequence ID" value="CAE1299462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DBG4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1299462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="265" mass="31147" checksum="50BD09B9F49350C6" modified="2021-09-29" version="1">MLYFTYIFASLLIILTFLFTSLFFSVSLSLSLSHTLPPYITFFFLSHYTGLILNLFLYFISFLLNHFYFLSYRYIFPLLFFFFYNFLCYLLLQSLSLSLSLPHFLFISLFLSVFLYCLLSLSLSKLFSLLFTFFFSLCHSLSSFLYCSLSHLLTAFNLLLPFSLTLIFSSFLPLFLFFSFCRVLLPLILVFQFTTLSSIYFYHSLLISLYQSPFSPFTLTLSFFLFSTGFFITLFFPLSFYHSLFSLSHYHSLSSPPPFISALLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DCP1</accession>
    <name>A0A812DCP1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_50513</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002987">
        <property type="protein sequence ID" value="CAE1294688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DCP1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1294688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="277" mass="34536" checksum="85F4DF6BA81A2B1B" modified="2021-09-29" version="1">MITPHPFVPTFFFFTQLLVLFSLLNDLPMATSTSVRIFSLLSFYLHSHFLLLNFFFFSLSFFYEFFFHYIYFKFFYYLFIYLFIILFPFFLFLLFLSFFVPSCFSIVVLSFLVFFSVFHLFAPSFFFFFNLLVFLSFFLSTFFFFLFFIILLILFVFYLFSFFFINFATSFFRFFFLFAYFVFFFFFSLLLAFLSLFLNSNLMPIFFIFFIIINYFFLFNYLVFLIFFFLSDNPPFFLSYSFICFSFFFFIFGFLFFFFFFVLFFFFLFFFVFVFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DF12</accession>
    <name>A0A812DF12_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_51739</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003157">
        <property type="protein sequence ID" value="CAE1296971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DF12"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1296971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="212" mass="24832" checksum="965406FEE86F74D7" modified="2021-09-29" version="1">MIARSRSMGPLPYLLVSTSVKSRANCVITIFFFFLLSFVLSFFLLKLLFFPCLFLSCFESFVTSFFLSVFLFALLLSFVTFCLVLLLSFFLSFFLSFFFLVLFLSFVISFFLSFFFLVLFLSFVISFFLSFFQTKLFPYFSLTFFYPFSPLISIFFLTCHPVYSFNSLTQSWLYSFTSIGSNYYLLFLPPPSVCFFFCLLSFKQILSACFPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DFB2</accession>
    <name>A0A812DFB2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_51865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003174">
        <property type="protein sequence ID" value="CAE1297196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DFB2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="266"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="296"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="321"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="351"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1297196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="444" mass="53361" checksum="47AD12C02F384579" modified="2021-09-29" version="1">MSLIFSLDIYSFSFFSACYPYIYFLFFLFLLGISTFCSFLFYFLAIYTSLFFPFFFACILFFHLCLHFSLIFTCEPTSFFFTFIFACDPYILFAFFFIYLPSLHSFSFLLYLLVILTSFFFFFFLAYDPYILFLFFHLFLRSLHTFSFLSSFLIPTYFFISFIFSSLHPFSFLSSFLMNPIYLFFSFLLANPWILFFIFVYNTYIFFLFFLIYFLCVHTFSFLSSFLVIPTYFFFSFIFSCKPYIIFHFFYLFLSLHPFSFLSSFLMIHTFFFLSYLLAIPTYVFFSILFTPIPSSFFFISFLLICSVFFFLAWDSFLHFHFLYFLLAIPISFLFFFLLYLLFAFDTFTFLSYLLVMITSFSFHSYLLATPAYFFFPSISACNPFIHFLSFHLCLQSIHPFSFLPSLLAIHSSIFFPSICACNPFIHFLSFHLCLQSIHPFSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DJC7</accession>
    <name>A0A812DJC7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_54010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003464">
        <property type="protein sequence ID" value="CAE1300707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DJC7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1300707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="287" mass="34554" checksum="F6478033805B97EF" modified="2021-09-29" version="1">MKDVTFCFFVSYLLQPHLLSPSTSPAIFFSLTRYPLPLNLISSSASPAILFRLTFYPLPPHLLSSSASPVILFRLTSYLLHPHLFSFFLSFFLSFFLSFFLSFFLPSFFFLSIYLFPSFFLLLSFYFFLSFFLSFFLSFFLSMYLFPSFFFLTSFFLSFFFSFFLSFFLSFFLSFFLSVCLSFFLSFFSSLFLSFFLFSFFFSFFFHSFFLSFFPSFFIFFFNNHLFLLSFFLPFFLNFLSFFLSFFLSFHLILSIFIIIFFFLFSYPSFLTFLSSFSFYHSHSFFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DKJ9</accession>
    <name>A0A812DKJ9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_58420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003993">
        <property type="protein sequence ID" value="CAE1306118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DKJ9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1306118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="268" mass="31742" checksum="A4BD7906F541A9E5" modified="2021-09-29" version="1">MQVRTLSKGTIYLSIYLSIYLSIYLSKSVPIYLSIYLSIYLSMSVPIYLSIYLSIYLSIYLWSKNRASPIHQWSGQARRQIYLSIYLSIYIYGGFLPSLLILISHNLSFFFFSISHFDFPLFLDQMLLFGFLFISFEIAFFFFFSSSVLFSTPLYPLVFLDLSTFFSFLSLLSTYHFWHASFFLLILSLSFFLLFLFSSISFFPFFSLFFYHFLFAFLFYFVIHLSLSLLISLYRRCTILSTYIASFLFTSLYRSRFLTRFLSLSVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DNM0</accession>
    <name>A0A812DNM0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">EIF2D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SPHA_57276</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Farmed</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF2D family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003856">
        <property type="protein sequence ID" value="CAE1304714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DNM0"/>
    <dbReference type="OrthoDB" id="199771at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11608">
        <property type="entry name" value="eIF2D_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11610">
        <property type="entry name" value="eIF2D_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21156">
        <property type="entry name" value="PUA_eIF2d-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.400.20:FF:000002">
        <property type="entry name" value="Eukaryotic translation initiation factor 2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.400.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039757">
        <property type="entry name" value="EIF2D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048247">
        <property type="entry name" value="eIF2D_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039759">
        <property type="entry name" value="eIF2D_SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041366">
        <property type="entry name" value="Pre-PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048248">
        <property type="entry name" value="PUA_eIF2d-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058886">
        <property type="entry name" value="SWIB_eIF2D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036885">
        <property type="entry name" value="SWIB_MDM2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003121">
        <property type="entry name" value="SWIB_MDM2_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004521">
        <property type="entry name" value="Uncharacterised_CHP00451"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057429">
        <property type="entry name" value="WH_eIF2D"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00451">
        <property type="entry name" value="unchar_dom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12217">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12217:SF4">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17832">
        <property type="entry name" value="Pre-PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26292">
        <property type="entry name" value="PUA_elF2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26291">
        <property type="entry name" value="SWIB_eIF2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25304">
        <property type="entry name" value="WHD_eIF2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47592">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51925">
        <property type="entry name" value="SWIB_MDM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DM2" evidence="5">
        <location>
            <begin position="388"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="SUI1" evidence="4">
        <location>
            <begin position="494"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="184"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="236"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAE1304714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="587" mass="66195" checksum="BAC2FFBB8F20831F" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DUP4</accession>
    <name>A0A812DUP4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_62757</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004489">
        <property type="protein sequence ID" value="CAE1311240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DUP4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="358"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1311240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="402" mass="46201" checksum="1139A2A0371E5187" modified="2021-09-29" version="1">MHSFILEQCFFLYACFFKKFRLSIYLSQFIYLAQSVLIYLSKSVLIYLSIYLSIYLSIYLSQPSIHYLSIYLCQSIHYPSILVRSLSICVSPFIIYLSMSVYSLSIYLCQFIHYPSILVHSISISVSPFIIYLSIYLCQSIHNPSMSVYSLSIYVSPFIIYLSLSVYSLSIYLCQSIHYPSMLVHSLSIYLSMSVYSLSIYLCQSIHYPSMLVHSLSIYVSLFIIHLSMSVHSLSIYVSPFIIYPFIYVSSFIIYPFIYVSSFIIYLFIYLYMSVYSLSIYLYQSIHYLCQFIHYLSISIIHLFHFVFFALLSLPLSLSLSLPLSLSMQICSSPIILFFYPISSLLSHVSPGLCSYCFVLNNWFSLLSVTLSFTVTVTHSLSLSPSLSPSLSPSLSLSLSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E2B6</accession>
    <name>A0A812E2B6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SPHA_66969</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004834">
        <property type="protein sequence ID" value="CAE1316197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000597762">
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    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1313629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="220" mass="26222" checksum="968446C43CD0CDFF" modified="2021-09-29" version="1">MSSSFSFYILSLSYLVFHLSIYLSIYLSIYLSIYLSIYQPIHIYLSIYLSIYLSIYLSYLSIYLSVRQFISIYLSIYLSIYLSIYLSIYLSIYLSINLPSYLSQPIHNAIYHIILNGSFILILVYLIYLSIYLSIYLSIYLYIHTYTHRFTGVNQRDLISIYLSIYLSIYLSIYEIIIYIFIYQKGSYTQFIKCLKLFLAQTHFSHDLSIYLSIYLSIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E7E8</accession>
    <name>A0A812E7E8_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">p53 and DNA damage-regulated protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SPHA_65807</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Farmed</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May play a role in chaperone-mediated protein folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the PAQosome complex which is responsible for the biogenesis of several protein complexes and which consists of R2TP complex members RUVBL1, RUVBL2, RPAP3 and PIH1D1, URI complex members PFDN2, PFDN6, PDRG1, UXT and URI1 as well as ASDURF, POLR2E and DNAAF10/WDR92.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004736">
        <property type="protein sequence ID" value="CAE1314805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E7E8"/>
    <dbReference type="OrthoDB" id="20282at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22860">
        <property type="entry name" value="PDRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030482">
        <property type="entry name" value="PDRG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21162">
        <property type="entry name" value="P53 AND DNA DAMAGE-REGULATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21162:SF0">
        <property type="entry name" value="P53 AND DNA DAMAGE-REGULATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="62"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAE1314805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="162" mass="18569" checksum="04174FEDC6506590" modified="2021-09-29" version="1">MKSNLLPPRAIILVSDIGIDRRSQLLTIGSGMAAQLSTANLISDLTEIEETAEKILTDKQQIVDLDKKRQQTREAIRVLNKDKVNNKCWVCIGNMFLKLPKKSTKNLLENDFNQLDREINSIRNDLKPKMNKLRDLENKDDLKGFNLEPLTKDEIRAIENLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E9D2</accession>
    <name>A0A812E9D2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_70903</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005193">
        <property type="protein sequence ID" value="CAE1320688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E9D2"/>
    <dbReference type="OrthoDB" id="1919336at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1320688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="322" mass="37318" checksum="40CA95A304D83DB9" modified="2021-09-29" version="1">MVLPDDDIYDDLEIMLPGHRKRLERAVVRLQKQSQSSNDVEYPVAYGKWMKPNYLEYAKFDFLCIDATIFSTKDKGQQEEIVFMVDSGSDVVTLRPEIVQRLNLVKKCTVRSQGVHVAKEKTLYEAKLKIGSVELKIELIPEEYNSLGNRVFRHFRHYINGSRHVWLKGDYMDPSMEVTTPEQHYNKEKFNNQSDLDDSTKLETELETETASSLKNECYKTLCKDSNLIEQSRSKDGTEEENEDEKMENAKLGESCRLEIGKCPDKDTASVENFLPSTSPKDELSPPVKTNPKQCFFSRKRQRATITSHFNKKARRKIKRND</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EAV6</accession>
    <name>A0A812EAV6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_71024</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005201">
        <property type="protein sequence ID" value="CAE1320825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EAV6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1320825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="217" mass="25771" checksum="604E8F96212D01CE" modified="2021-09-29" version="1">MNHVYDILYLSQSVHIYLSIYLSIYLSIYLCSLSIYISISLFIYLRTLQCVIFFFSSVSFFSLFSSFSSSFFPFRNYTSMRHFLLFHVLSLFLLLLHLLLHSFRHFNGSFSSSFLLLLLLLLLCKHLMYHFLLFHLLLFLRNCTLLVKLSVCSYLSIYLSIYLSIYLSIYLSHLFIIYLSIYISLFIIYLSIYLSIYLSIYLSIYLSIYLSVMGPYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ECQ6</accession>
    <name>A0A812ECQ6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_71079</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005202">
        <property type="protein sequence ID" value="CAE1320942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ECQ6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1320942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="292" mass="31486" checksum="975C37D3F689DC4C" modified="2021-09-29" version="1">MAIGCHEDGDLLSSTMNSGMNLSLSLSLSLSLSLFLPSLPLSLFQLFLWGDDDVDSHGESFYANESNDDDEVFADTIPADMLTHTAPLLTEAPSTLHPNFSTSDSNSLSRDDVHGTALSCSHSSLSSSLQTDDNGSSPCDVCTSSSRHCTFCNRNNANSNQLAHQSSNMTSQSTDNDRDRLENDQPLAGRRRHCSSDTDEDSLGGNATSGQDSVASGNQLAVTKKKQPPPKGQRKRPPRKTIDHTGGVLATTFMLSSFTFCALCIDTSPEIFIVAIFMAAFMFQVIQQLNSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EDU5</accession>
    <name>A0A812EDU5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_71728</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005255">
        <property type="protein sequence ID" value="CAE1321665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EDU5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1321665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="166" mass="19567" checksum="EC495E4D765FAB4A" modified="2021-09-29" version="1">MSRFVGRIKNKCLCVETKAPRSCCCRRTRRSIDSFDSVRGNDVTWDGHGRVCLSIYVYKLNLSIYLSIYLSIFFSLFIHHYKSRSIYLSIYLSIYLSIYLCVCVFVSIYLSMCVCVRIYLSIYLSIYLSIFISLIFFLSFFLSFFFFLFSLPYALTLLSFFPFSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EEZ5</accession>
    <name>A0A812EEZ5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PPP2R5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SPHA_73993</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Farmed</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphatase 2A regulatory subunit B56 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005404">
        <property type="protein sequence ID" value="CAE1324238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EEZ5"/>
    <dbReference type="OrthoDB" id="10264446at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072542">
        <property type="term" value="F:protein phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002554">
        <property type="entry name" value="PP2A_B56"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE 2A PP2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257:SF5">
        <property type="entry name" value="WIDERBORST, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01603">
        <property type="entry name" value="B56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="137"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAE1324238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="185" mass="20918" checksum="AF85FA2974FD3B6C" modified="2021-09-29" version="1">MIDPFTSKAAIKSKRQKRSQGSSHYRTKNAPELQALPHLKDTSPAEQQDLFIKKLQQCCLVFDFMDPVSDLKSKEIKRACLNELVDYITATRGVLTEPVYSEIVRMVVFSASSVLDCGMYAACLPDTKGMHYTTRDLLRIVLTAIFHLAAYNFITYPPLPPHISLSPSYIHQSLDEIVIFIPTHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EFY2</accession>
    <name>A0A812EFY2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_71832</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005269">
        <property type="protein sequence ID" value="CAE1321798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EFY2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1321798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="266" mass="32276" checksum="91FC79F6B284E77D" modified="2021-09-29" version="1">MQRPNLSKIFLLTLSVCLSLSLSLFLRTKYQESILLNKRHGRKEYIKKYYIIPLHRNYIYLSIYLSIYLSIFLTASIALLLPLIVDGSCKREFEVTTQYLFVVRTRRHQIESYLHFLFFSLWRFRLLPSFVTFFLSIYLSMYLSITIVFFFLSFFLSFFLSFFLSFCLWYLSFFFFLFSFNRFILCLWYLSIYLSIYLSIYISIYGSIFMFFLYVILSFFQLQVFLSFRSFTYFLFTFFFVSLFIFLSFCFSLFLACSISSFVVIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EI89</accession>
    <name>A0A812EI89_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SEA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_75940</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005477">
        <property type="protein sequence ID" value="CAE1326368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EI89"/>
    <dbReference type="OrthoDB" id="9908153at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.960">
        <property type="entry name" value="SEA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000082">
        <property type="entry name" value="SEA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036364">
        <property type="entry name" value="SEA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01390">
        <property type="entry name" value="SEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00200">
        <property type="entry name" value="SEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82671">
        <property type="entry name" value="SEA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50024">
        <property type="entry name" value="SEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEA" evidence="2">
        <location>
            <begin position="31"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="173"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="216"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1326368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="266" mass="28790" checksum="E0E93D889B580D66" modified="2021-09-29" version="1">MGVLLTTATALSVIFVRDDVTTSSDDNQKYKMVKINGDVKFEETWKSIYSNHSSPEYRIRSQLFIKKMDNYFKNSSLANLYNRTEVINFRKGSLVIKFNSFFKKSKPTVSTTFIMDTVLKIIQIVFPKSHVIISDSTTSSTLSTTMVTTTTPLEITTTSTEAPSPTTVTTVAVTTTSPTTTSPTTASPTTTATTMSSSLKPSTAIKTTKAISSLSMTTTSPKSPGTMTTTKTTAEKQSSPAAGPATSKTTTIPSGKTFLYFSKAFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EJG4</accession>
    <name>A0A812EJG4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_72000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005285">
        <property type="protein sequence ID" value="CAE1321984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EJG4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="285"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1321984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="304" mass="37171" checksum="03ED7F703D7DC2A0" modified="2021-09-29" version="1">MDRKYAESFTHERKHYKTSDDRSIISTRVRISFKSFLNHIDILSFFLSFFLSFFLSFHYNNHSVQKYLSSASYEYLSFFLSFFLSFFHSFIFLLTFIFLYHLNFFLSFFSFFSFFFHYNNHSIQSFVFGFFILLLYHFLSFFLSFLFSFHYNNHSSSVSLEYLSFFFLSFFLSFLFIIHSVQSPLVIHANLHFFVSSLSFFIFLFFLSFFLSFHYNNHSVQIFCIHLNFFLSFFLSFHYNNHSIKSLFFLSFICYSLLYLPFFFLSFFLSFFSFFIINNHSVKNLLYHLNIFFFLSFFLSFFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EKF5</accession>
    <name>A0A812EKF5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_74724</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005438">
        <property type="protein sequence ID" value="CAE1325083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EKF5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="352"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1325083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="376" mass="41313" checksum="3C70BE056136397D" modified="2021-09-29" version="1">MSSLSIYLSIYLSICLENNHIYLQYFPSFLTSLNSFSISIPSFSLFISISTPYLTFRPHPLSLSYPPPTYFTIFCLVPLSQFTPSIFTSSLSLSLPLPPSLSLSLSLIVAILCSNLPLCDGMLLSLSLSLSLSLCPFISFLLSTNLSQLSLSSSLFFSLSLSHCRYLYLIPTFSLFFSLSFPLSLSLSLPLSLPLSLPPSLSLSLSLSLSLSLIVVICPHIQKALQSILYTIISLFIILCSVSYSSSVAICYTFFVSFLLQITSSLFSHSPSLSLFLFFYHANLSTLQKNSPTILWSTISLFDIYCSLSLSLSLSLSLSLSLSLSRYITPLYSFVSFRFSTILIRLSPSSSLYLTSLCLSVSLSLSVCLSLSLSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EL80</accession>
    <name>A0A812EL80_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_74499</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005433">
        <property type="protein sequence ID" value="CAE1324831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EL80"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="377"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1324831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="403" mass="47561" checksum="37A664DD39A23E37" modified="2021-09-29" version="1">MRKKSQFYSYIFVFPPHIYLSIYLSIYLSISHKSIYLSIYLSIYLSICLSIYLSQSLHLSIYHNLSIYLSIYLSIYHNLFIYLSITIYLSIYLSITISSSIYLSQSIYLSIYLSIYLSQSLHLSIYHNLSIYLSIYLSIYHNLFIYLSITIYLSITIYLSITISSSIYLSQSIYLSQSIYLSQSLHLSIYHNLSIYLSIYLSIYHNLFIYLSITIYLSIYLSIYLSQSLHLSIYHNLSIYLSIYLSIYLSQSLHLSIYHNLSIYLSIYLSISLSLFLFIYLSIYVVSFYLSISIYLVSFFYYLSFFLSFLLSFFLSFSNNGGPLYLSIYLSIYLSMSFIYLWIKLSKSLISIYLSIYGTSYLSIYLSIYLFRSFISIYLFIYLGTSYVSRHFISIYLSIYLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EM07</accession>
    <name>A0A812EM07_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_73684</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005385">
        <property type="protein sequence ID" value="CAE1323884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EM07"/>
    <dbReference type="OrthoDB" id="300855at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1323884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="291" mass="33712" checksum="71EECE9FD3860C8F" modified="2021-09-29" version="1">MNSGNIEYYSGEVELNAKFRTFAKNANLVFCGHNTVAAQLKINSKREYTDIGGNEELPLGEEFNSHVKCFMNLQEKKVEKRFEPAAILIEQLHISAKETRLNEVKRKEMDELNIKCLQVLRALIHNEERKLSEDWEIRTGETKIIKQLKIIATLQRFYDRCGAMNKCLPHLASRNDDIAKEVLGFLCIMLFNANQTVQHSMLEYFLSTREEVFFMAVRDRMQLSINSIKEKRSLQAQQKARQQEAADTFGFTSTDYSFTVSKLAIKQIKAYEDALREQRLSGWVSLSFHSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EM56</accession>
    <name>A0A812EM56_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_77086</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005504">
        <property type="protein sequence ID" value="CAE1327663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EM56"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34723:SF7">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34723">
        <property type="entry name" value="PROTEIN CBG17025"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1327663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="286" mass="33276" checksum="D8C2B26A33B650FF" modified="2021-09-29" version="1">MLFLSFFLSFFLSSQFFLSFFLSFFLSFFLSFFLLSHLLTLLYIELENAYQYFSHFYIHTYISFSSSLFRFILFVLSFSLFHFFVCLLNFLFPFFLILIYLLFLPFFVSFFFFPCLFHLLFSFLSFYIIFLPSYLPSFLPSSLPLFLPSFVPPSLPSFLPSFLPSFLPSFLPSLPPFLSSFLPSFRPPFLRSFIPPSLHSFLHSSLPSYVPSFFLSFLSPSLPSFVPSFLPPSLSSFLPSALPSFVPSFLPFFLCPFLPSFFSSSLPPFLPSFVSLPFFFASSQKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EN24</accession>
    <name>A0A812EN24_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ANO10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_78877</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005552">
        <property type="protein sequence ID" value="CAE1329314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EN24"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1329314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="204" mass="23274" checksum="E8C4F19A584565C5" modified="2021-09-29" version="1">MDADICDTQVITIQHPDNNGHRRNGLLLVYRRGTPRYARKGCFLILFTYSHLSLSHFLSVSFSFLQFATDSLLPHSLPISVHLSFPLLLLVRHSLSFSITHTHTLSLFLSLYVPVRLFLFSTFFYYSLSLSLSLYFSHSLCLCLYLSLFPCIVYFFLYISHPPSLMISFSLSFSLCSIPLFSTGLLNFISHSLPVRLSIFPAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EN84</accession>
    <name>A0A812EN84_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_78897</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005553">
        <property type="protein sequence ID" value="CAE1329413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EN84"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1329413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="249" mass="29300" checksum="7D42586B192EB58F" modified="2021-09-29" version="1">MSLSLSIYLLSIRLYIHSFIFPSLSVLSCKSFLFLLQLYLNIKSGFLPEFFSNFLCLTAAILVYLPYFHIYLYICLLSFHIYLSIYLSIYLSIYLSIYLSLSLYIYIYIYIYNEFSHLSTVFSYSSVCLSLYLSVCLSIYLSIYLSTLYSYLSTVYSYLSIYSSIYLTTLYSYLSTLYLYLSTVYSHLSIYLSIYLSIYLLFIFVCLSIYLSVSLSIYLLSFHIYLSIYLSIYLSIYLSIYLSMCVSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EQL6</accession>
    <name>A0A812EQL6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_76777</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005497">
        <property type="protein sequence ID" value="CAE1327277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EQL6"/>
    <dbReference type="OrthoDB" id="6153892at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786:SF74">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786">
        <property type="entry name" value="DNA BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1327277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="333" mass="37597" checksum="CA968414959F2435" modified="2021-09-29" version="1">MSVVCGHCNAKNWPGESAGLCCSDGKVQLPPFQELPAPLKSLLEGSSPDSKHFLAKIRQYNCTFQMTSSGGNAFREVSWNPTFKFQGQVYHRIGSLLPETAIDSAFPQIYFIADYNQQGDARIGIILENDTGQHNHPRRDIIMCLQQMLHEINSYVRSFKYALKNNTSSDFIIVIDADKWPQREHVCKYINKETDAAMFGIRQEGSVDEIQDFLAGRVISSTEGPWHIFSFPIHERFPAIVQLTVHLENDELRYFSADAAMHVAARTKDTTLTAFFKLCRQDEFARTLLGSAEARGQRRGLSRRQKRRHTRKGIHGSPIATGMSLLATPFARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EUY3</accession>
    <name>A0A812EUY3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_78240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005532">
        <property type="protein sequence ID" value="CAE1328599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EUY3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1328599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="157" mass="18479" checksum="AC139575C85D7289" modified="2021-09-29" version="1">MISLILMIYIIPFYLSIFLSVHIYLSIYLSIYLSIYLSIYLQVATYALISIAVSIYLSIYLSIYLSIYLSITNKELYQLTVTTSEMSTLAIIYLSIYLSIYLSIYLSILVFSLSIYLKLFIIYPSYYFHYLSIYLSIYLSIYLSIYHVNIFASIFCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AL73</accession>
    <name>A0A812AL73_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WDR45</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SPHA_951</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Farmed</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat PROPPIN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000026">
        <property type="protein sequence ID" value="CAE1141798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AL73"/>
    <dbReference type="OrthoDB" id="1667587at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048720">
        <property type="entry name" value="PROPPIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11227">
        <property type="entry name" value="WD-REPEAT PROTEIN INTERACTING WITH PHOSPHOINOSIDES WIPI -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21032">
        <property type="entry name" value="PROPPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="256"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="286"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAE1141798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="314" mass="33910" checksum="554ACC2FB41AFD83" modified="2021-09-29" version="1">MCPNSNNSLLAFPGRKTGHVQLVDLANTEKSPLDIPAHEAALSCIALNLQGTRLGTASEKGTLIRVFDTSDCTQLHELRRGANSAHIYCLNFNQDSTLLCVSSDHGTVHIFSCEDPKKNKQSSLASASFLPKYFSSKWSFSKFQVPGAATQCICAFGSDNNSVIVVCADGSYYKFSFNNKGDCTRELFLLVISFSQFLHLTTPPSPSLSLSLLSSPLPLSLSLSSPPPSLSLSPPSLPSLHLPTPPLSPPLYPPSLIYISLSLSLFLCLSFFVSLSLSFFTLTISLSLSLSLSLSLSLSLYPCLLSLSIYLSRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AMD3</accession>
    <name>A0A812AMD3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_1144</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000031">
        <property type="protein sequence ID" value="CAE1142926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AMD3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1142926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="196" mass="23054" checksum="EB87AE5BD2E3D4DD" modified="2021-09-29" version="1">MSLYSSHLTVYLSLFFFFLFVSFFHYFSFVSLFLLLSLSVSPFVSLCFSLFLFFSISFCFSLFLSFLLLFIFSFLLLSSFLLLSSFLLSLFLFPSLSISLSFSLYFSFLLSLFLFLSLFLFLSLFLSVSVIREREIEKQKIFLLFFNFSLSLSLSLSIFPSFFTFPFLFLSFFSLFKSFYPCLSFTLYNLFMSGCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AP97</accession>
    <name>A0A812AP97_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_2960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000086">
        <property type="protein sequence ID" value="CAE1150614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AP97"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1150614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="341" mass="37900" checksum="918B6BB830FA1737" modified="2021-09-29" version="1">MEVRKRLRSIEEVFQGNNCPYTFRVPRSALAIIEKSALPTKLVSAIKGWRDPRKDEWVLVELYRYPRVETLFTGDFFSAISHISLKLSEEQSYLTNFRGFRYNGDKICIISADISTNIEAFERTHKCTQLCTMEMPVNQSIPIAIPANASFDNGLNYPASAPVLGDFHFWSREPIPMPPPYSKHPPPLSLALSLTRSLTLPPSLTLSLSHTHSLTLYLSISHSLFLSLTLPLSHLLSLTLSNSLTLSLSLSLSLTLSLTFSLSHSSSLSHFSLSLLTLLYLSHSLSHSLSHSLFLSLSLSHSLLSLSLSLSLTLSLTLSPSLTLSFTHTHTMFSKNVLIGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ATN2</accession>
    <name>A0A812ATN2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_4960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000163">
        <property type="protein sequence ID" value="CAE1156879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ATN2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1156879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="270" mass="31601" checksum="CB5BE939C0A0F0C3" modified="2021-09-29" version="1">MGYLSIYLSIYLSIYLSICFKLFISIYLSIYLSIYLSIYLSIYLSASNFSYLSIYLSQTFHIYLSDSNFSNLSIYLSASNFSYLSIYLSIYLSIYLSIYLSIYVEVIIHLSIYLSIYLSIYLSIYLSIYLSLFLYDLAIYHKISAQFGWETTYLSYVFIVNIILYLSLCLPLSLSIYPCQYFNICTSAHLSIYLSIYLSIYLSIYLSIYLSMCISFFFSLFLTMFIIYLSIYLSIYLSISVYSFPIGLLVFITVSIHPHFLFLQIFSCID</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ATT9</accession>
    <name>A0A812ATT9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_4908</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000161">
        <property type="protein sequence ID" value="CAE1156770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ATT9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1156770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="151" mass="18459" checksum="B8F6B3EC68A11FC9" modified="2021-09-29" version="1">MQTQQKFLLRYLKQNHEEMNLFFVCLHFFLHFSLNFCDTFILNFFECPYDVYFKLFSFFRHFSHYFLSFCSFLFFLPFFLCFLFTCFFFNLFLLFSPSKLKVDCLDSAQEYFLAVYPHVLITTNKQKHLSIYLSIYLSIYLSMHGRVSGYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ATV4</accession>
    <name>A0A812ATV4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_5552</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000183">
        <property type="protein sequence ID" value="CAE1158383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ATV4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1158383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="168" mass="19284" checksum="831E4B599FD16D8A" modified="2021-09-29" version="1">MSHSLSLFIYFLSLPLSENSINMYVFSPIVVLSLMRFICSLFTTSFLSFFLSSFIYFSSPFFSKILFLLLSLLLSLPLSLFHSTVYPLILKYSLLLLSLEAFHFSFLSSVFSNLHTNFAYLGIHLRVTYRFTRGSVSKILRFSPAMLLLVFSDEGDVDRGEEEEEEDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AUQ5</accession>
    <name>A0A812AUQ5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_6092</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000200">
        <property type="protein sequence ID" value="CAE1159681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AUQ5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1159681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="380" mass="41111" checksum="9B0A9EECF843E516" modified="2021-09-29" version="1">MLLPSTLFLSSSNSLTFFLPATLPLSLFLQLFLIFSISVTLSLSLQLSLSSYSCKYFSSFLPANLSLSLQLSLSLFLPFFLQLSLSSFLSSSSFLSSSNSLSSFLSSSNSLSLPSFLPPTLSLPSFLPPTLSLPSFLPPTLSLFLPFFLQLSLSSFLSSSNSLSLSSFLSSSNSLFLPFFLQLSLSLFPSFLPPTLSLSLPSFLPPTLSLSSFLSSSNSLSLSSFLSSSNSLSLSSFLSSSNSLSLSPSTFFLLLSLSLPSFNTLSPFLQHSLYLPSCNSLSLPSFLQLSLSPFLPATLSLTLPSTLSPFLHLFHSSLLANLSLSLLSSCKSLSLSLLLSTFQQHSLSLSTFQQLPLFLSLSFHNPLLKSFLLCHFLLNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AXH9</accession>
    <name>A0A812AXH9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_7118</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
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    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <source>
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        <source>
            <dbReference type="EMBL" id="CAE1162011.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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                <person name="Bekaert M."/>
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    </reference>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Acanthosepion pharaonis</name>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </evidence>
    <sequence length="2019" mass="235874" checksum="9ABC034C4092E50B" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B1B7</accession>
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        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <dbReference type="GO" id="GO:0048788">
        <property type="term" value="C:cytoskeleton of presynaptic active zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098982">
        <property type="term" value="C:GABA-ergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098882">
        <property type="term" value="F:structural constituent of presynaptic active zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904071">
        <property type="term" value="P:presynaptic active zone assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035418">
        <property type="term" value="P:protein localization to synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06714">
        <property type="entry name" value="PDZ_RIM-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052098">
        <property type="entry name" value="Presynaptic_Scaffold_Bsn/Pclo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14113">
        <property type="entry name" value="PICCOLO/BASSOON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14113:SF6">
        <property type="entry name" value="PROTEIN PICCOLO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="3">
        <location>
            <begin position="817"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="29"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="333"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="277"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="62"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="114"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="128"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="159"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="207"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="346"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="411"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAE1170175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="946" mass="104122" checksum="26D05B28C2AC64CE" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B6J1</accession>
    <name>A0A812B6J1_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_11621</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000383">
        <property type="protein sequence ID" value="CAE1171519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B6J1"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS"/>
    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF284">
        <property type="entry name" value="EG:103B4.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="195"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAE1171519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="341" mass="37891" checksum="878CC4DE007B8DDD" modified="2021-09-29" version="1">MLPHDLVIFTITPIIYLSIYLSIYLSIYLSIYLSIYILFISIYLSIYLSIYLSHSVHIYLSIYLSIYLSIYKYRIGFASCFCYVNSFILAGLEFGNAGKYLIAALSLASPVCSIAYPNLIPVFVEKYTWRGSMLMLAGINLQTIPFALFLLLSHKYRKNNQTKIDAGTKKASSEPIPLTASKTAFDISLFKIPIYVAYLCAVTFTLTGSNAMYSLLASFFHKKGLSLKDAAMLYSVYCVIFFVPRASIGFLQRWIKIPFIYIFIALSLLSGSLCILIIQAESYFALLSFAIVLSLCLGGPSGLYSIGTLEIVGIEKYSFATSVIETSYGVGTAVFGYLAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B6T5</accession>
    <name>A0A812B6T5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_12079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000402">
        <property type="protein sequence ID" value="CAE1172403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B6T5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1172403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="173" mass="19773" checksum="8CC500B6E840AB2C" modified="2021-09-29" version="1">MSYVCFERLAYNNNYVEFVFEIILIYLSIYLSIYCGLFIFIYLSTYQSIYRSICLGLFISIYLSIYLSIYLSIYLSIAFIASSTHCAKFVCVCVCVCVCVCVADCSYISIYQSIYRSICFGLFISIYLSIYLSSAFIASSTHCAKFLCVCVCVSVCLYLSIYLSIYLSIYLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B7D0</accession>
    <name>A0A812B7D0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_12197</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000405">
        <property type="protein sequence ID" value="CAE1172654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B7D0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="284"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="313"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="348"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="400"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="433"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="508"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="542"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1172654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="572" mass="69708" checksum="C4C8A8DDA6A996C6" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B8G3</accession>
    <name>A0A812B8G3_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Meiosis-specific nuclear structural protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SPHA_12131</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Farmed</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating. May play a role in the control of meiotic division and germ cell differentiation through regulation of pairing and recombination during meiosis. Required for sperm flagella assembly. May play a role in the assembly and function of the outer dynein arm-docking complex (ODA-DC). ODA-DC mediates outer dynein arms (ODA) binding onto the axonemal doublet microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Flagellum axoneme</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MNS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000402">
        <property type="protein sequence ID" value="CAE1172474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B8G3"/>
    <dbReference type="OrthoDB" id="197839at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044782">
        <property type="term" value="P:cilium organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026504">
        <property type="entry name" value="MNS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043597">
        <property type="entry name" value="TPH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19265">
        <property type="entry name" value="MEIOSIS-SPECIFIC NUCLEAR STRUCTURAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19265:SF0">
        <property type="entry name" value="MEIOSIS-SPECIFIC NUCLEAR STRUCTURAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13868">
        <property type="entry name" value="TPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="7 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0282">Flagellum</keyword>
    <keyword evidence="11" id="KW-0469">Meiosis</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trichohyalin-plectin-homology" evidence="15">
        <location>
            <begin position="112"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="57"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="271"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="417"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF13868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAE1172474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="495" mass="60980" checksum="4D025479B7B2717F" modified="2021-09-29" version="1">MAHVRRYTLQQREKLLQSQHRADEERKAILKQLELENMAQSHKNIEAMSEERRYNRRLAMERKERELEEGILQAERNQIAHKQQVEQEERLAQEIKRRNLEKMRDEKMRQQIRENSLEIRELEEKLKAAYLNKARAAQIAEKELQRLQQMKAETILFHEMNKELEKAKCEEQVKEEERQKLQMVYQQQLEKQLEEQEQKKQQAYEDFLHEKRMIDEIVRKILDEDQKERERQMAKQQETQAYITEFLEARECWKEQERLKMEEENKKILEYAQLQSERQHQQKQQKAEREAILSKTHQVLSEQIAREEREREELEKIRLELCLEEQEEKTRQEEMATLEKKIRARLELQRINEQQMALRAAQKVAEEEEERRFREMMMAKFAEDDRLEQMNAQKRRMKQLDHRREVERIIEERRVKRIRERHEEDEMQRELRQLEELKKAIVEEERQKLLKEHAQKLIGYLPKGVIQSEKDLDMLGEDFKKVYSKRERDPFDEEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B920</accession>
    <name>A0A812B920_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_13748</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000461">
        <property type="protein sequence ID" value="CAE1175633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B920"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1175633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="191" mass="21758" checksum="0208472F65567747" modified="2021-09-29" version="1">MQSQEEAILVSGQQEKTTEFAKTMKIGHLMIGGKIVWSDESNFEKSLHLSFSLSFFLPFFLSFFLSFFLSFFLSFFLSLSLSFFLFCLVFPLSLSSHNFPLSFSLSFSHSLSLSFTFSLVFLFLFIPSTRVVGTVRYLTAKRDIPISNGIRGLHLEASNYSCRHGKVCLFFASKERRQGEVGSIRVREGWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B9V2</accession>
    <name>A0A812B9V2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_12344</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000413">
        <property type="protein sequence ID" value="CAE1172947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B9V2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1172947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="166" mass="19994" checksum="CEEF750AC35DCF3C" modified="2021-09-29" version="1">MFLSIYVSGCASSHLSIYLSIYLSIFIYFHVSIYISTYLSIYVYSDLAIYLCTYQYTLYHCTYRFIYLYHCWLSMLTSIYLSIYLTEYLSIYLSIYLSIYDLSIQPFMFFSFYLSMYVLIYLFIYLSMPSLRSEFTVFLIIQLNSSGPFFSLSSRFLYFYFLPSYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BAY4</accession>
    <name>A0A812BAY4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SPHA_13969</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000472">
        <property type="protein sequence ID" value="CAE1176050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BAY4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033065281" evidence="3">
        <location>
            <begin position="24"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="226"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="346"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="375"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="407"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="440"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="479"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="543"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAE1176050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="566" mass="67179" checksum="169864596E325E58" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BFF5</accession>
    <name>A0A812BFF5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_15784</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000552">
        <property type="protein sequence ID" value="CAE1225687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BFF5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="335"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1225687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="427" mass="50675" checksum="646774F37EC456B3" modified="2021-09-29" version="1">MYLLSIYPHFTLFLSIYLSIYLSIYLSIYLSISILLSSYLSIYLNFTLFLPTYLPTYPIYLSIYLSIIYLSIYLSIYLSIYLTLSLSIYLSIYLSIYLSIYLSIYLSIYLSQFNSLRIYLSIYLNFTLFVPTYLPTYLPTYLSIYLSIYLSIHIYLNLTHLLSIYLSISIYLNFISLHILPTYLSTYLSIYLSQFYSLRTYLPTYLSIYLSIYLSIYLSIYLSIYLNLTHFVSIYLSISILLSSCLPTYLPTYPSIYLSIYLSIYLSNLTHFLLVHLSRNLSISYFLNLSFLFTYLLFPRLFSYGHLSIYLFLYFQSIFKTHTLSHTHSSIYTSIYLSIHISIYLTTLYYLSIYLSSIDFYLSKTSDKIHYLTSLTRMEHTHTHHTHITSHLSIYLSIYLSIYLLYSHNYSYNIYSFSLSIYFLLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BFP8</accession>
    <name>A0A812BFP8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_15988</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000558">
        <property type="protein sequence ID" value="CAE1226298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BFP8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="247"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="277"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="403"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="441"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="471"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="496"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="531"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="568"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="600"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1226298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="631" mass="76226" checksum="70C431AF4B572D33" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BJ00</accession>
    <name>A0A812BJ00_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 11">Annexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SPHA_17558</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Farmed</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in reproduction of the worm. Involved in host-parasite interaction. Delivered into the host cell by means of parasite exosomes. Binds to acidic phospholipid membranes in a calcium-dependent manner in vitro. Causes aggregation of liposomes in the presence of calcium, but not in its absence. Likely to promote membrane fusion. May provide structural integrity within the tegument.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Host cell</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Extracellular exosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Tegument</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">A pair of annexin repeats may form one binding site for calcium and phospholipid.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the annexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000628">
        <property type="protein sequence ID" value="CAE1230049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BJ00"/>
    <dbReference type="OrthoDB" id="37886at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043657">
        <property type="term" value="C:host cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000001">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000002">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000003">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000004">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.10">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001464">
        <property type="entry name" value="Annexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018502">
        <property type="entry name" value="Annexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018252">
        <property type="entry name" value="Annexin_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037104">
        <property type="entry name" value="Annexin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502">
        <property type="entry name" value="ANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502:SF102">
        <property type="entry name" value="ANNEXIN B11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00191">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00196">
        <property type="entry name" value="ANNEXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00335">
        <property type="entry name" value="ANX"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47874">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00223">
        <property type="entry name" value="ANNEXIN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51897">
        <property type="entry name" value="ANNEXIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0041">Annexin</keyword>
    <keyword evidence="5 11" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 11" id="KW-0111">Calcium/phospholipid-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="125"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="138"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="179"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="226"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00059330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00060393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00077076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAE1230049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="588" mass="64930" checksum="D19B63E80F14C01B" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BKC0</accession>
    <name>A0A812BKC0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNAJC16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_18233</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000657">
        <property type="protein sequence ID" value="CAE1231747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BKC0"/>
    <dbReference type="OrthoDB" id="10065037at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052448">
        <property type="entry name" value="DnaJ_C16_autophagy_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44303">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44303:SF2">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="348"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="90"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1231747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="413" mass="47593" checksum="F9C18D261EA0B06C" modified="2021-09-29" version="1">MDRFTKINEAYETLGDPEKRSLYDMHGYTVTQEEPHPRKSSSNNNRGYTNFRSGPFGSYNLISGAESIIDKYMITQRFYETRIQLESFRVPYFIYAYADGCLICLHYEPLIEKLIKEIVKVGIGIGTIHVSSNRALGSNLRINEVPQIMAVVNGRITYFKRQVSMQNLRDFIRNLFPPSTIQLITDKNFDEFLHSWSDNRMRALFFSPREKPPLRFLMPAFSRREKIASRFVNTRSPLVEGILRRYNVNKAKDTLLMVGESSNSTVAVVTMRTLSKGSIDEVMEANQYLTLPRLSSQVFFDELCPVEIRVKRRKLSLIILLLSFLLSYSLFLLFLLPNLSSPTPSISFFLPLLSTIPTALIIYFFSSHSYHLLIFFPSSLQHFTSSSLSSPHSYNFFSFYLDTLPPPHSLPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BKF7</accession>
    <name>A0A812BKF7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">SPAG1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SPHA_19052</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000690">
        <property type="protein sequence ID" value="CAE1233679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BKF7"/>
    <dbReference type="OrthoDB" id="2942533at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006626">
        <property type="term" value="P:protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051982">
        <property type="entry name" value="CiliaryAsmbly_MitoImport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45984">
        <property type="entry name" value="RNA (RNA) POLYMERASE II ASSOCIATED PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45984:SF1">
        <property type="entry name" value="SPAG1 AXONEMAL DYNEIN ASSEMBLY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="790"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="892"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="929"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="975"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1003"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="220"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="287"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="735"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="8">
        <location>
            <begin position="880"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="128"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="365"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="668"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="142"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="391"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="418"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="674"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="721"/>
            <end position="739"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAE1233679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1029" mass="115485" checksum="11CBD14BC6D32674" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BLB5</accession>
    <name>A0A812BLB5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_19720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000716">
        <property type="protein sequence ID" value="CAE1235280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BLB5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1235280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="289" mass="33358" checksum="BF0681F87200F2BB" modified="2021-09-29" version="1">MSGRVVTTALFTGGGKGWYFPCWDSTISAPSFSFLFLFPLFNLSRLNELLADFERTGPNIRRLALIDQMAHHCFKQIFLLSRSFLLVLYRSYSRRTEIKKTFLFYLNLLTKKSRRNHFFLLRKSTITCINSSFASFLFFSFPLFFFFLFTKSSLLLSDLLSPAFFSFLFSLLSFSPIIPSYTPLSLFLYSQCFFSSHPCFSSFVLTFPFSNSPDAPSLSFFFLSFLLTSNFSDGPGSFRVVSLPLEYQALNIESGLFFSKFFFFISFQALFLLSLLLSWISSFLLFIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BLI9</accession>
    <name>A0A812BLI9_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Retropepsins domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SPHA_19561</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000709">
        <property type="protein sequence ID" value="CAE1234877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BLI9"/>
    <dbReference type="OrthoDB" id="5918705at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018061">
        <property type="entry name" value="Retropepsins"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00077">
        <property type="entry name" value="RVP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Retropepsins" evidence="3">
        <location>
            <begin position="51"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAE1234877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="271" mass="29512" checksum="CA4274F87E006E7B" modified="2021-09-29" version="1">MREQPMEPSTTTLLSLQRVRPCSKGLLGKGVRGQGAVATLAPSRSVNVALPVVNVCVEGKRCSALIDTGCSRSIVSVDRCVTWSNQQIEIRTIDGVSQACCGVGTVSILTDGGNHAKVDVLVARQRPLGYDLLLSIDAIRALGGMIITPAGNGKVNCPHQNGQRGILTTPPFSLFYFLSLLSLSLSILHFFPISLSRLNSFLLSFPLYHYYIFHPSSSFAHLPSLSHSFSHNYFFFLSPTTCQMTFVSPPHSFLLSLTYLTLPLCIPELLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BNV9</accession>
    <name>A0A812BNV9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SPHA_24031</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000891">
        <property type="protein sequence ID" value="CAE1243869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032865695" evidence="3">
        <location>
            <begin position="16"/>
            <end position="1802"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="95"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="152"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1246"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1273"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1323"/>
            <end position="1344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1356"/>
            <end position="1374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1380"/>
            <end position="1406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1413"/>
            <end position="1436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1448"/>
            <end position="1468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1475"/>
            <end position="1496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1502"/>
            <end position="1522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1534"/>
            <end position="1557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1569"/>
            <end position="1601"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1622"/>
            <end position="1643"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1649"/>
            <end position="1671"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1683"/>
            <end position="1705"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1717"/>
            <end position="1740"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1752"/>
            <end position="1771"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1777"/>
            <end position="1800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="418"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="699"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="914"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="708"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="916"/>
            <end position="930"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAE1243869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1802" mass="208653" checksum="0B088DA5A337E2E3" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BP08</accession>
    <name>A0A812BP08_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_21268</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000780">
        <property type="protein sequence ID" value="CAE1238367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BP08"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1238367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="254" mass="31223" checksum="9CA21BD185E093CC" modified="2021-09-29" version="1">MIVLLLLKFCFGTFVFIPSFFHLTHFPSFFTIIFYLLYLFTFSILLSLFLFCQLLSFLSYFYLFNFTLFSIFFYFYNLNFFLHFSLFRSYFLSFCFTLSILPSFIFYFFHLTPFFFFILFPSYPLSFFFYFFHFTHFDFLFLFFPSYFLAIFVILIRFFLIFNYSILLPFLLFTFPSCFLSFKFYFFHVTYFPSSFFHFHLSSFPSFLSLLPFLLFFFYRLISSSSVSLYLLSFLLTFSTLLLFSLCHLTFFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BQ66</accession>
    <name>A0A812BQ66_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_24790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000931">
        <property type="protein sequence ID" value="CAE1245572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BQ66"/>
    <dbReference type="OrthoDB" id="1919336at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1245572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="254" mass="29207" checksum="ABEED622917B4E08" modified="2021-09-29" version="1">MLNSDNCLIPLKEDSLSEVEHLPGLSLADEEYFHEPFLCYLKNKNPATEGFNSVFDNSSGLQLFDPINESNVPENNQSTDDVFPELNDVVPVCKQAYPNLLNGDPMLPQVMDCPRIKCTKNRKYEVNLVESAEELQFVPPDSVTPVGLITFHPNAPVSHELNNNCQMLPEKNIKEENESPNKPSLQRPLRGVVGKKGDDQFESYCWKFHEIANIRRQKVELTAVKEERFDQIEEKMEKVVERLLFLFNYCQKYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BQD0</accession>
    <name>A0A812BQD0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_24893</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000937">
        <property type="protein sequence ID" value="CAE1245828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BQD0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1245828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="154" mass="19269" checksum="E994BCDCF8492948" modified="2021-09-29" version="1">MFSFFFSFFPSFLSFFLSFPLSFFSFFLFFFPFFFLFLLLSSFFSFFLSFFLSFFLSFFYSFFLSSFLFYFLFFLFLILFSFFLFYFLFFLFLILSFSLFSFFLSFYFLFFLFLILSFSLSFFLSFFFSFLFLVLYLFIYSLSFFLLFLSYSTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BQE7</accession>
    <name>A0A812BQE7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_22041</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000813">
        <property type="protein sequence ID" value="CAE1239904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BQE7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1239904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="216" mass="23610" checksum="79FC42CBFF9F51F1" modified="2021-09-29" version="1">MIFFSFKSQLLSQFCFHFYSSFSFSNLILLLLLLLLLLLLLLLLFASYLFYFPFSSSLFAWSSFFLPFSFFSLSSPFSSSRFSSSSPYASFSSSPISFSPFASSSSFPFSSSSFSLFSSFLFSSSSSSSSSSSSSSFVFIFSLFFFFSPCFVFISFSLSLSFRFVSLSSSSFYSSSLFASSSSSPFSSSFSSSSFSSSSSSTSFSPFSSSSSLASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BS57</accession>
    <name>A0A812BS57_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_21910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000806">
        <property type="protein sequence ID" value="CAE1239661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BS57"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1239661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="274" mass="30717" checksum="FF8F666663BFDECA" modified="2021-09-29" version="1">MSKTKRKKSNTERNPVITFFSFSSVYLLSIDFFAVFVSCVYRILRCKRKRENEKCKWRDERGRGGNPATYEEDLSVCLYVCLFLSHSLSLSLILFLSLSHSLSLSHSLSLSLSFTFSLSHSLSLSFSFSLILFLALSHFLSLSLSFSSSLSLSFSFSISHSLSLALILFLSLSIILFLYLSFSFSRSYSLSLSHSHSLFSLSFSLSLFLFLSHSLSLSFSFSLSHSPSLSLILLLSLILFLSHSLSLSLCLILFLSSLSFSFSAILYASFFSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BS91</accession>
    <name>A0A812BS91_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_21986</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000811">
        <property type="protein sequence ID" value="CAE1239806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BS91"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1239806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="214" mass="26429" checksum="F73CF6CE400F64B9" modified="2021-09-29" version="1">MVFCHCASPWLTTLPTLLFVRLALLFLFFALLSFCLPFFFYIFSFLGFSFFLFFFFLHVLFFFTLFLDFVFSLSLFFFFFFFFFTLFSLLFTFLFFTRLPFSFLHFLFFKTLSFLFFFKLFLFLCTSFFHTSLFGLFSCLFYTFVFYTLFSLHFSLRFKLFLFLYFSVFFSFCTFLYFFLSFLFYTFSHVFCALFSYFYSFSSCFLTFSLFFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BTB0</accession>
    <name>A0A812BTB0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_21822</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000802">
        <property type="protein sequence ID" value="CAE1239350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BTB0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="286"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1239350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="309" mass="37052" checksum="A9647208010E9836" modified="2021-09-29" version="1">MCFFCFVLFSLFFLLYSYLKFSFFLFVYQLHFVCLFVFSNHFIYIFILSFLLFSFIHSYFLSLFISLFLFIHITVPLYFTFFHSYNRFISFFLFSLLLYQNISFFLSFLSHINLLSLFLSLFFLSFFLSFFLPNFIRFIALLLNGHFYNVNFFLHFFVPSPPYVVFSFKFQPPKISSFNFFLSFFLSFFLSFFLSSLQNPIISFFLSFFLSSLQNPLISFFLSFFLSLPSFFVTLFVSFFLSLRKLLLFFLSFFLSFFLSFCYYLNFSFSSVFLTSGLLPLSSVSFDFFLLSLFPVHWPIIVLLSHSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BTM0</accession>
    <name>A0A812BTM0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_26641</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001017">
        <property type="protein sequence ID" value="CAE1249527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BTM0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="612"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="279"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="375"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1249527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="693" mass="73052" checksum="FBEAA5B4A565FFF2" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BWT8</accession>
    <name>A0A812BWT8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_23136</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000857">
        <property type="protein sequence ID" value="CAE1242114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BWT8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="297"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1242114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="317" mass="37799" checksum="D119138B342C9015" modified="2021-09-29" version="1">MFLFLILDLFFLSFVLFFFFLSFFFLFFLNISKSYHIFSFFSFLHLIIFFLSFFLSFFLSFFLKYFKFSSSFFLSYKKLDVCFPVLSIYLSIYLSIYLSISVDSNLSIYLSIYLSIYLSIYLSIFGFALCNTGGVAFFIFFHFSSSFLLSVFPSSKSSLFSFLTFFFYFFHFSPYFCCFFIFSPTFYLSLFFSLFSSFSHVIPFYFALLFSFFTFSSFSFSPSKLSFFLSFIVSLTPFPFSLFIFPFSLHLIFHTFIFLFLFYFSVFSPSSPLLLIFPSLLTIFLTCYFLFLLFFPLLFFTIFLLSFLFCLSFSRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BZJ2</accession>
    <name>A0A812BZJ2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_28506</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001114">
        <property type="protein sequence ID" value="CAE1253474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BZJ2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1253474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="153" mass="18197" checksum="1E2DF24F4837F846" modified="2021-09-29" version="1">MYLPIYLFISISICSYLSKSAHISLNLFISIYLSIYLSIYLSIYLSIYLSLFICMYVCTYIRMYYVCIYLNLFISLSICSYLSHSVHTYHNLFISIYLSIYLSIYLSIYLSIYLLQSVQDLSIYFLLAFFCLIEYIFFVEKMSPYISGIVRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BZL5</accession>
    <name>A0A812BZL5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_27021</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001037">
        <property type="protein sequence ID" value="CAE1250274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BZL5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1250274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="331" mass="37102" checksum="4BA07F020CDFE289" modified="2021-09-29" version="1">MPAGRLLFVDTFCRLSDESRGRLTGGKMPTVQRTLNGCSFQNAQAASQTSGGVFALKQQGFLPIHFKANVGKRLAAFRCRTNQTCKRFIAAPCILIADITFHCKLKCTAFTTLLQLPFDSPRRPRLRKQHVTQRRLRQRPFDGAGNPWLRRPHAMQPTPLQLLLKVCRKVPRTGRQRDAISTSADRAVEGPTKRLERLQTVNQRRHAQRGLCSPPKQFWFKLAFNYEPELRLLCRKDLQIGSMSVVCGHCNAKKCPGESADLCCSDANEPKLLIGQRATYDAILASTRQDTGSISFLDAKNVRNKNDAGDENARSCNEAFARLICATTKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C369</accession>
    <name>A0A812C369_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_30466</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001224">
        <property type="protein sequence ID" value="CAE1256877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C369"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1256877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="166" mass="19683" checksum="E6E0B4EE32BB0F5E" modified="2021-09-29" version="1">MNILEKIFLLFFFFLFFFLLLLLLLLLSFVSFLFYFFFSPPYNFFSHFLFILSSLFFFLFFILLSFLLFTSFFLLFSSSLLSFFFLFSSSFLSSSSFFSFLFLLFSFSPLFSSPYSSFSSSSYFGFFCSPSPLFFFSFVVPFFFYCFLLSYFSPQSSSSFSSSFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C4A6</accession>
    <name>A0A812C4A6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_28049</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001104">
        <property type="protein sequence ID" value="CAE1252621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C4A6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1252621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="192" mass="23398" checksum="3949318CAE22F7B8" modified="2021-09-29" version="1">MFVLSFQPFIFSFQPALFFYLQTFFLFFPTFLLVFLTIHFFPSNLFFYFQLFFPVFSILSTFFSFQPFIFSFQPFIFSFQPFIFFLPTFHFFIPTFHFFIPTFYFFLPTFHFFIPNFHFFIPTFHFSNPSVFSNIFPSKYSFFFRTFYLFVLITFLFFFPNFIFSNFFSILTFCLLSAIQLVSCASFSSSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C7M9</accession>
    <name>A0A812C7M9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="22">ADGRL1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">SPHA_34172</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001446">
        <property type="protein sequence ID" value="CAE1264301.1"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="entry name" value="Gal_Rha_Lectin_dCirl"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GPCR_2_extracellular_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003924">
        <property type="entry name" value="GPCR_2_latrophilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
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        <property type="entry name" value="GPCR_2_secretin-like_CS"/>
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        <property type="entry name" value="Ig-like_dom_sf"/>
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        <property type="entry name" value="Ig_I-set"/>
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        <property type="entry name" value="Ig_sub"/>
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        <property type="entry name" value="Lectin_gal-bd_dom"/>
    </dbReference>
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        <property type="entry name" value="Lectin_gal-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="ADHESION G PROTEIN-COUPLED RECEPTOR L2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="SUEL_Lectin"/>
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        <property type="entry name" value="GPCRSECRETIN"/>
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        <property type="entry name" value="SUEL_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0297">G-protein coupled receptor</keyword>
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    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
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    <keyword evidence="6 16" id="KW-0732">Signal</keyword>
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    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 15" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032907815" evidence="16">
        <location>
            <begin position="28"/>
            <end position="1323"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="732"/>
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    <feature type="transmembrane region" description="Helical" evidence="15">
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    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="802"/>
            <end position="825"/>
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    <feature type="transmembrane region" description="Helical" evidence="15">
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            <begin position="837"/>
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    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="876"/>
            <end position="901"/>
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    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="922"/>
            <end position="944"/>
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    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="950"/>
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    <feature type="domain" description="SUEL-type lectin" evidence="19">
        <location>
            <begin position="39"/>
            <end position="130"/>
        </location>
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        <location>
            <begin position="117"/>
            <end position="222"/>
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    <feature type="domain" description="G-protein coupled receptors family 2 profile 1" evidence="18">
        <location>
            <begin position="328"/>
            <end position="382"/>
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        <location>
            <begin position="508"/>
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        <location>
            <begin position="733"/>
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        <location>
            <begin position="1024"/>
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            <begin position="291"/>
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        </location>
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            <begin position="1312"/>
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        <source>
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        <source>
            <dbReference type="PROSITE" id="PS50227"/>
        </source>
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        <source>
            <dbReference type="PROSITE" id="PS50228"/>
        </source>
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        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
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        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAE1264301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1323" mass="148340" checksum="C73295EF35C3DB56" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C807</accession>
    <name>A0A812C807_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_28602</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Spiralia</taxon>
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            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001118">
        <property type="protein sequence ID" value="CAE1253760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="6"/>
            <end position="22"/>
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        <location>
            <begin position="34"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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        </location>
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            <end position="290"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAE1253760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="307" mass="36470" checksum="D59385C357DC76EA" modified="2021-09-29" version="1">MNEIKYFALIIYLSIYLSIYLSPKGLLLRLNLRFPLLILSLSLSLYLSIYLSLFISIYLSIYLSIYLSIYLSQPFYIYLSIYLSIYLSIYLFQSVPPLSLSLSLSIYLSIYLSQPVFIYLSIYLSIYLSIYLSFISSLFIYLSIYLSIYLLYLTMFISIYLSIYLSIYLSIYLLQPVCLSFFHSVHIYLSIYLSIYLSHSVLSIYLNLFFLSFFLSFFLSFFLSFFLSQPLLSSFLSFYSFQTLLSFFLSFSLCPYLSIYLSIYLSIYLNLFFLSFFLSFFLSFFLHALTYTHTHTLKYMVQYDHRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C8Q7</accession>
    <name>A0A812C8Q7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_30445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001224">
        <property type="protein sequence ID" value="CAE1256870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C8Q7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033060581" evidence="1">
        <location>
            <begin position="22"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1256870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="373" mass="42324" checksum="025DB1D3B6D02CDE" modified="2021-09-29" version="1">MNTRNLLVSIILIAFQCRNNALLLGVQQKAVFNKNLTSRSFAVGDTLISRTRPTLPPGRCHVSLTVNPSPAILGSLVTFYSMLNCSVIPPIEYQCCYYFWQDNFSENTSMTVGLMTSFLSKIYEPRSIMRNKYIMEVMVCWKKILVKSQRKDLKNSVCNYSVALNTTVFELTVTLNGFLKFKQDRDYRGSPSVLMVGKESVAMFVPTDQRLEMLTYKWRVNASIYMESRNSSIHFIPANVGMISVEVHVFDNVSHNIGHFKHSIQCKDPILDAFIKGDKQLLVESNGTFIVTYVGSAPFSFCWRVEPSDYSEDWTCMYNLSNTVGNVMGSAVFSVQANRQSGQQKIIANLTNDVSKKVLTFQFRVFPTGEFFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C9W1</accession>
    <name>A0A812C9W1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_32862</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001369">
        <property type="protein sequence ID" value="CAE1261683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C9W1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="274"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="309"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1261683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="333" mass="40181" checksum="0E6727F475DD85AB" modified="2021-09-29" version="1">MHSVVHSVLHFVVHSVLHSVVHSVVHSVMHSVVHSAVHSVVHSVLHSVSLFCLSLILLISFILPLFFLSFFLSFFQHHELFIHFILFSYLSFLLAFFLLFPSIFIFLENFPSFCFFLFFLSRFLFSALHLSFFLSFFLSFFLSSLHFSSVHYASLSFFLSFFLPAYCTFFQRLSHVFLSFVLFFIRSFFLCPPLFFFLKTSFHFPCFFLLFIFSSVHYAVLSFFLSFFLSFFLLMHFLCFKSSSYILSFFLSFFLSFLFFLESFFSFFYRSRPFFFLASALYPFFFFFKHTFIFLLFRFIYFILSFFHSFFHSFFLSFFHSFLLSFFLTFFYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CB13</accession>
    <name>A0A812CB13_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_31757</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001313">
        <property type="protein sequence ID" value="CAE1259646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CB13"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1259646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="347" mass="40236" checksum="DFD2032C89B16C37" modified="2021-09-29" version="1">MSFQGIGNGVVAGCPPCASSIRLTTHQTTCSISKLIEIEDLTTDRRCYVERLNINRNICIFEILLVLNFPSSSFSPPLYLPLYFPLSISPFLVNSFSFSLTHSLTFFSHNFSHTLYAPHTLVSSHILLRSLFLSRYLLTLAHLLISRVYHELEYNFFFICLYKCCSQSIYFCSYLSIYLSIYLSIRINLSQFIRIYLSIYLSIYLSIYLSIYLSIYLSIRHVPSSINLYIYLSIYLSIYLSIYLNLIYLSIYLSIYLSIYLSIYLSKSFLSISVFSLSIYLSIYLSITIYLSIYLSIYLSIYHSAFESFILIFLSLSLSLSLYLSIYLSRTHILVRLYAVETLPVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CBQ6</accession>
    <name>A0A812CBQ6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_32201</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001335">
        <property type="protein sequence ID" value="CAE1260358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CBQ6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1260358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="244" mass="28425" checksum="9B001785985E6500" modified="2021-09-29" version="1">MKDYLNPTEPELLGFFFQGLNYWPLISAVRARTTGHSSLPSGRELLDTHLCRQGANYWTLIPAAEARTVFCLNSHFYLSIYLSIYLSIYLSISNCLYLSIYLSIYLSQTVYIYLSYSVHIYLSIYLSIYLSIYLSPKLFISIYLSIYLSILFCSYLSISLSISNCLYLFIYLNLFISIYLSIYLSIYLSKSVHIFLPQSIYLSIYLSIYLSILFCLYLSIYLSIYLSILFCSYLSIYLSIYLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CE34</accession>
    <name>A0A812CE34_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">OA1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SPHA_33133</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001387">
        <property type="protein sequence ID" value="CAE1262300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CE34"/>
    <dbReference type="OrthoDB" id="10069455at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035240">
        <property type="term" value="F:dopamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072544">
        <property type="term" value="F:L-DOPA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035643">
        <property type="term" value="F:L-DOPA receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072545">
        <property type="term" value="F:L-tyrosine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032438">
        <property type="term" value="P:melanosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050848">
        <property type="term" value="P:regulation of calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001414">
        <property type="entry name" value="GPR143"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15177">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15177:SF2">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02101">
        <property type="entry name" value="Ocular_alb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="31"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAE1262300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="279" mass="32423" checksum="BCD76C14BDC1475E" modified="2021-09-29" version="1">MFFLFKQFSKRNVEEIPCLILCSEYNLKKFLHEILTTILFQTTLLIPGLKLPKPQPLNEVIRWLAVADILMALGFFTRSIVWLLGQTPYPQIPKVSVKHEVCVAVTVWIEFCCISTYMWNFTYGLDVFLVTHNKSRLKFLWPVLNWIIPGLLTGVGAFYIYYPSLSQCGGPNMKEVVNYVAYFFPMSLVIVFKSIVIRQHGRYSGAEQTLVQNAKRKFYLIMTVFIACWFPNVINAILDAFQFTNSLGKAMWAMWVLKTKRPTIQQETKNPIIHRMIEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CEA8</accession>
    <name>A0A812CEA8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_34436</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001460">
        <property type="protein sequence ID" value="CAE1264934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CEA8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1264934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="234" mass="28184" checksum="765AB64985DF0993" modified="2021-09-29" version="1">MSAVIFFMLNRSIYFCIRFFLVFLEKNFPLAFCICRFIFFLSGFSLIFSGFYISSCCSFFLSFFLSFFLSLFLSFFLSFCSSFLSFSFIYSPHSVFLYFLDSAFPHFLSFSFCYVHAFFLFYILHFPIFFVSLSLSFTYIISFFFFLYLKCFPIYSLFLFSVFIFNSFISPLSFFSFLLNVPVSHSFFDTFHHISFFFFVLFFFLNFYSFCQNQHQNINIIFRALTIDCLHLLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CHM4</accession>
    <name>A0A812CHM4_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Proline-rich transmembrane protein 3/4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SPHA_35440</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001524">
        <property type="protein sequence ID" value="CAE1267006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CHM4"/>
    <dbReference type="OrthoDB" id="10066605at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059081">
        <property type="entry name" value="PRRT3-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052836">
        <property type="entry name" value="PRRT_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35578:SF6">
        <property type="entry name" value="PROLINE-RICH TRANSMEMBRANE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35578">
        <property type="entry name" value="PROLINE-RICH TRANSMEMBRANE PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25987">
        <property type="entry name" value="PRRT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="255"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="284"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="351"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="388"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Proline-rich transmembrane protein 3/4" evidence="9">
        <location>
            <begin position="128"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="51"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="527"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="108"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAE1267006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="722" mass="80893" checksum="792C7530B383568E" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CL51</accession>
    <name>A0A812CL51_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_36108</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001571">
        <property type="protein sequence ID" value="CAE1268502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CL51"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="329"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="365"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="412"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="442"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="477"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="509"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="534"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="561"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1268502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="584" mass="68959" checksum="9FBD41E73AC0EAC8" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CN88</accession>
    <name>A0A812CN88_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_40326</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001902">
        <property type="protein sequence ID" value="CAE1276942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CN88"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1276942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="202" mass="24242" checksum="D32564D9D28CAD04" modified="2021-09-29" version="1">MFISIYLSIYLSIFQICSSIYLSIYLSIYLKIYLSIQIFFIYLSIYFYLSIYLSISMFMSIYISKMFPYLSIYHLSIYLSIYLFYLFISIYLSKCSLSIYLSIYLNVYVYLYIKMFFLSIYLSIYSYLSIYLSSIFYPNYVLYIYLSIYLSAMQKFEAILGRLFLFHNISRALSQSIFHSLSLFLPLSLIPPLSELKPFKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CNU2</accession>
    <name>A0A812CNU2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_40678</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001928">
        <property type="protein sequence ID" value="CAE1277475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CNU2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1277475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="231" mass="29029" checksum="6A2A3FDB3731B121" modified="2021-09-29" version="1">MLKFFFFSFFVKKKKLFYQSYSLLFFLFSFLLYCSFFLSFFLSKCFFFLFLFYFSFLHSSFLIIFSFFFSFFLFFLSFLSFFSFFLFFFFFFFFLFFFFLFFFFFFFFLSLNFYFSLFFFFSVVTIRTLTFLSFFLSFFFLFFCYELSSFFLSFFLSFFFLFLSIFIVNSLKFHFKIFTFFFFLFLSFVFFLCFQVIFLILFLSLLFFFLSTSKDGCRPICRGSSHSFFPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CPI8</accession>
    <name>A0A812CPI8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_38621</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001761">
        <property type="protein sequence ID" value="CAE1274064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CPI8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="327"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1274064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="346" mass="41431" checksum="ECB9131AB3DDD784" modified="2021-09-29" version="1">MMEAGDYGSPAQSSTSAAFQNPVSANRTSRLTIYCVSIQNINYLFFLSFFLSFFLSFFLALCFPSFVFFICLFLLRPFVFLLSILYASLSFFLSFFFFFLSFFYLFVPFFSFFFFLLYMLPPSLLSFFYFPFFFLFFFPLATFRLPFLAFYMLPFLSFFLSFVCFSFFFLSFFLSFLSFFSFCFLSFSFFFFLSFFFFPPSVFFFCFFSFSDLSSSLLSILYATLSSFFLSFFLSFFLSFFLSFFLSFFLFPPFVFFICFFSFSDLSSSLLSILYASVSFFLSFFLSFFLSFFLSFFSLLRLLYFFFLLATFRLPFLAFYMLPFPSFFLSFFLSFFLSFFLILHPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CQ68</accession>
    <name>A0A812CQ68_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_38644</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001766">
        <property type="protein sequence ID" value="CAE1274127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CQ68"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="337"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="393"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1274127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="415" mass="47776" checksum="0BB58FD93EC0C26B" modified="2021-09-29" version="1">MIYIYLYLSLSISISIYLYISLYIYLYISILPYFTHHVGWIFNMTKTRVLNSCALSLSIYLSLSISIYLYLSLSISLSKHLSIYLISISISLSISISLYLSISIYLYLSISPIYLYLSLTLSISLSLSISISYLSLYLSLSISISIYLSLSLSLSISISKSLSLSLSLSIFISISFSLYLYLFISLSISIYKISRTIYILSIYLNSTSHIYLSILSIYLISIYLSQPIHLYLSISRSIYLSLTPASSYHLSIYLSFSISVLFISICLSQDLSIYLTIGILIYLSIYLSPNLSRFSSLLPSISKIYLSSFLTHLPSTILLSIYLSIYLKLFVFFYLRFIYIFISTFLEYLYILSIIYLSIYIIHLNVKFKILYLSFLSPPYLSIYLPINLSIHHFNFLTLFLSIYLKSIYVSIYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CRF1</accession>
    <name>A0A812CRF1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_38670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001768">
        <property type="protein sequence ID" value="CAE1274199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CRF1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1274199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="224" mass="27149" checksum="7ADE88E3B7AD1F81" modified="2021-09-29" version="1">MVIFNFFLLEFVCFNNHSFVRHFFFITSNQYCLLFYLFCLLFLLLYSIFLSFSFSFSFFLFFCHFSSHYISVCWFPPTNTFSLLKSYLFIFNLLSFITYTFSRLSYFPYLSFCVFSFLLFFILFSPSFIYSFLLLLLLLLLLLLLLSIALIYSLFLFFFYFSFTLLYILFLSFIPHFVYFYEILYSFSLVFIHFSSLNLISFLLLLLSFQIKMITHAFFSVCFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CT67</accession>
    <name>A0A812CT67_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_41634</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002010">
        <property type="protein sequence ID" value="CAE1279158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CT67"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="312"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="340"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="379"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="408"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="435"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="469"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="496"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="541"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="568"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="594"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1279158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="616" mass="75894" checksum="5D462737053602AB" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CTL7</accession>
    <name>A0A812CTL7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_41466</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001990">
        <property type="protein sequence ID" value="CAE1278776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CTL7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1278776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="250" mass="28634" checksum="E130E830BE54818E" modified="2021-09-29" version="1">MEVKFVKACRCEKNQGSTRKEYDVERTKILEIPRNITSLTTFFSLSKRSILRNIVIASTVYVCACVRNSFLSCNDLKVADLGTSPPKKKYLRPYFVLSLSLSLSLSLFSLIFIQILTFFLSLGRCFDGSIVFESTFKIITLPQTTNLFILPFPLCFFFSLSMISLSIYIYLPIKHFLITANLFPSPYALSTGVLSVRDSPLISIYLSIYLSIYLSIYLSIYLSIYLSLILIYLSIYLSIYLSIYLSIYLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CZ73</accession>
    <name>A0A812CZ73_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">VPS9 domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_43587</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002195">
        <property type="protein sequence ID" value="CAE1282644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CZ73"/>
    <dbReference type="OrthoDB" id="10264848at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045046">
        <property type="entry name" value="Vps9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101">
        <property type="entry name" value="RAB GDP/GTP EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101:SF98">
        <property type="entry name" value="VPS9 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00167">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VPS9" evidence="2">
        <location>
            <begin position="488"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1282644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="649" mass="74058" checksum="D76DBD96967E1D53" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D083</accession>
    <name>A0A812D083_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_46972</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002517">
        <property type="protein sequence ID" value="CAE1288190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D083"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1288190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="249" mass="28555" checksum="54D6480C29CFD8B5" modified="2021-09-29" version="1">MKILHTDDTSIYLSIYLSIYLSMSVCSYLSLSLSLTLSLSLFSRTRVVYFPLFIPIYLSLYLYPSVHIYLSIYLSIYVSLFIFVSLFHSLSLLSLSHARCLCPSVHIYLSIYVSLFIFVSLSLSFSLSFLMHARCLFPSVHTSLSIYIPLFIYIYLSIYGSLYIFVSLFHSLSLSLTHERFLSPSVHVYLSIYLSIYLSISILASKERPWRIGHGKPLAFCQSDQPSVSEFVIARKSVIARPCHLLKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D1D5</accession>
    <name>A0A812D1D5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_44119</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002236">
        <property type="protein sequence ID" value="CAE1283485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D1D5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1283485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="221" mass="25261" checksum="930AE22ECE19FE81" modified="2021-09-29" version="1">MNVRPFLVESLKSMMVTPFLLESLKSMTVTPFLVELLKSMKVRPFLVESLKSMMVTPFLIESLKSRNVRPILVKSLKRMMVTPFLVESLKSMTVTLFFDESLKSMKVRPFLVDSLKSMTVTPFLVDSLKSMMVTPFLVESLKSMTVTPFLVESLKSMKVRPFLVESLKSMKVRPFLVESLKSMKVRPFLVESLKIMTVTPFLVDSLKSMTVRPFLVESLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D1N8</accession>
    <name>A0A812D1N8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_47185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    <dbReference type="AlphaFoldDB" id="A0A812D1N8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
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        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
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        </source>
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        <source>
            <dbReference type="EMBL" id="CAE1288542.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D344</accession>
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        <submittedName>
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        </submittedName>
    </protein>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">Farmed</strain>
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    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAE1285028.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Acanthosepion pharaonis</name>
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            <strain evidence="2">Farmed</strain>
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    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <source>
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        </source>
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        <source>
            <dbReference type="EMBL" id="CAE1287239.1"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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</entry>
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    <name>A0A812D3N3_ACAPH</name>
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    <organism evidence="7 8">
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    <comment type="subcellular location">
        <subcellularLocation>
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        </subcellularLocation>
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    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
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        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAE1286497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="613" mass="73578" checksum="4DF9A52D6AA56328" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D452</accession>
    <name>A0A812D452_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_46295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002445">
        <property type="protein sequence ID" value="CAE1286947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D452"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1286947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="195" mass="22865" checksum="B0B1B7EF144144FA" modified="2021-09-29" version="1">MIYLSIYLSIYLSIYLSIYCESLVCLPRFCSQVILGLIEFSDVFFFTVYYFLFILYFPLLFLYSSVSLLLFSFLLLLYFTPFHFEDATLPLSLSLSLPLSLSHSLPHSLSHSLSLPLPPSHSLHCLEITTMKHLSDNLLYLSDSFYLSDSLLYLFIYLVLFFMCLILFIYLSIYLSIYLSIYLSIYLSIYLIRFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D7L5</accession>
    <name>A0A812D7L5_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SPHA_48723</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002730">
        <property type="protein sequence ID" value="CAE1291363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6092644at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01644">
        <property type="entry name" value="RT_pepA17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040676">
        <property type="entry name" value="DUF5641"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008042">
        <property type="entry name" value="Retrotrans_Pao"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF6">
        <property type="entry name" value="DOUBLECORTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18701">
        <property type="entry name" value="DUF5641"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05380">
        <property type="entry name" value="Peptidase_A17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="2010"/>
            <end position="2032"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="2039"/>
            <end position="2055"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="2093"/>
            <end position="2110"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="4">
        <location>
            <begin position="1689"/>
            <end position="1883"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="262"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="544"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="214"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="284"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="330"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="547"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAE1291363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="2116" mass="240501" checksum="8615E3834BAF115C" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D8N8</accession>
    <name>A0A812D8N8_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SPHA_48143</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002655">
        <property type="protein sequence ID" value="CAE1290250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D8N8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="190"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="252"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAE1290250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="335" mass="40267" checksum="D4DCF860304E6738" modified="2021-09-29" version="1">MIIAPFLLLLLLIIIIIIIIIIIIIIISPLFVLLLIIIAPLLVLLLIIIIIIAPLFSSSYYHYYYCYLLSFPSLLSLLLLLPSFLPIIIIIIITATFFPSHHYYHYYYSSPSSSHTYYYHRYLLLLQPFSFSSSSSFSHYYYYCSPYSSFHYYYYYYYYYYYYYYYYCPLLFLIIIISFPLLVLLLLIKIIIIIIIIASFLFFSLSLLLLLLLIPFSSSFHYYYYYYYYYCFPSFLLIIIIIIIIDPILLLLLVLLIIIIIAPLFFYLLLLLLLPLLVFSLLLLLSSSSSFFFLLLLLIIIITIIVPLFSSPSYFYCYPSSSSHYYYYYYYYYYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D9S2</accession>
    <name>A0A812D9S2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein MON2 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_48743</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002733">
        <property type="protein sequence ID" value="CAE1291413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D9S2"/>
    <dbReference type="OrthoDB" id="294853at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032817">
        <property type="entry name" value="Mon2_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16206">
        <property type="entry name" value="Mon2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mon2 C-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1291413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="372" mass="41455" checksum="6251BC7DF46D6607" modified="2021-09-29" version="1">MCLFSKLGELCVDQRPATRKSAGQTLFSTLSAHGSLLQKDTWKKVLWQVLFPLLEHVQKLSSKASTSKDESSGGNILIHHSRDTAEKQWAETRVLTLAGVARTFNSKRMILQTIGDFPRAWSLLLEHIEYSALCPNAEVSLAALKSFQEIIQINKDSKEKGDDLRISRGSVTPPGEEVMNRSSEDGHDAPNKPVQNDSGKVEYNLTLWSTAWRVWLNIGMLSTKPPEGKSQKPYIPSQAFVTALAQTFPPLFHHIKSRFVAADLQKLSTVLRSALSVPVHGDMSPFIIPTYPDLTITPLQESTLNAVQVLIKAIKNGSESMQNMYPDLFDQLLIYIEYGVKPPKYGDVETKNFGSVKGPQVSMIILIKKFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DBN4</accession>
    <name>A0A812DBN4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_52943</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003327">
        <property type="protein sequence ID" value="CAE1298978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DBN4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1298978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="224" mass="26144" checksum="055BEB8A6C4E279C" modified="2021-09-29" version="1">MFSFFLSFFLSFFFLSFFLSFFVFFKLRFFLSFFLSFFLFTSLTIIFFSFLVYRFHLFILFLFLTFPLIHISFAFLSPLFSSPFCLPPYFIHFLSSNNHSVISSSSSSSSSSSSSSSSNISFPLFLLLFLLSSFLFFLSHLLLISSSILSFFLSFFLSFFLSFFLKIYLSIYLSIYLSIYLSIYHSVHIDLSVYNYLPISLASYLSSFLSITVCSCLSQSLYIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DEW7</accession>
    <name>A0A812DEW7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_54901</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003625">
        <property type="protein sequence ID" value="CAE1302293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DEW7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="308"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="351"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="382"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="421"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="448"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="477"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="502"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1302293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="521" mass="61385" checksum="76FEDEE05A4623FD" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DF82</accession>
    <name>A0A812DF82_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_51742</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003161">
        <property type="protein sequence ID" value="CAE1296986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DF82"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1296986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="241" mass="28704" checksum="DEA2DD79F5B20A31" modified="2021-09-29" version="1">MFSYLFFFWVRLRTFERSIYLSIYLSIYLSIYLSIYLSNFLIFIASIYLSIYLSIYLSIYLSAKNFERISYLSIYLSIYLSIYLSDLSIYLIVSIYLSIYLSIYLSIYDSLSNIGISTHRIYLSIYLSIYLSIYLIYLSIYLSDSRAIVHIGILSMSTISLNDTNFSYPSIYLSIYLSIYLFFHQTHRFRAIVHYTIHHFSITVHYFTTWCTNFYLSIYLSIYLSIYLSIYLSISDSLSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DFS7</accession>
    <name>A0A812DFS7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_52081</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003209">
        <property type="protein sequence ID" value="CAE1297585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DFS7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="179"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="232"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1297585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="246" mass="26255" checksum="91B4DCDDFAA04478" modified="2021-09-29" version="1">MAPRPADERQALGAHPSGSAPPRTEGAASSPPASRRYPRAAILVSNTRHDELGPASARDDRHIAKRPRRPPAASAASTPRNNALPAGRPCAALIRSSRDSATMMAMRLVPIDDIGDQRCGSPPRHRHGCAAAVHRAFDAHDARQLDRGVDHRRIRIHRQQMRRPAARKARSVSGAPSGQRAISIAAPVAANPPPQRQAARRAESAAPRASINATRASLAGRTRPAYRPPAAPHRAAPSTRSPSRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DQG4</accession>
    <name>A0A812DQG4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_60300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004187">
        <property type="protein sequence ID" value="CAE1308405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DQG4"/>
    <dbReference type="OrthoDB" id="8957827at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="313"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="399"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="430"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="455"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="483"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="515"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="549"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="575"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="617"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="647"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="675"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="697"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="729"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="753"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="792"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="898"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="924"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="956"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="984"/>
            <end position="1004"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1308405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1007" mass="113887" checksum="E8B6EB5BE19D4A91" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DRB0</accession>
    <name>A0A812DRB0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_58854</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004051">
        <property type="protein sequence ID" value="CAE1306648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DRB0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="273"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1306648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="305" mass="35392" checksum="5D4345D8DDA8D5C9" modified="2021-09-29" version="1">MSIYLSLIHHSSIFHFSSIHLIHLSIPSIYLSHLSIYPSIFISYSSIYHFQSFHLSISSIHLSIHPSIHHHLSIHIHLSIISIYPSIHSSIHLSKSIHLSIHQSIHPSIHLSIHPSIIHPSIHPSIHPSIHPSIYLHPSIHLIYLSIHPSIHLSCSYLSIYLSIYLSIYLSFPNIFSIYLSESACLYLYLSIYLSIYHKHVHVLSIYLFIYLSIYFYLSILFISIYLSIYLSIYLILRSKGSVHIYLSLHLSHSVHIYLSLHLSHSVHIYLSIYLSIYLFIYLSIYLSIYLSIYLSIYLSILSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DRI2</accession>
    <name>A0A812DRI2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TMEM126A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SPHA_61345</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004332">
        <property type="protein sequence ID" value="CAE1309666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DRI2"/>
    <dbReference type="OrthoDB" id="6234762at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009801">
        <property type="entry name" value="TMEM126"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16296:SF2">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 126A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16296">
        <property type="entry name" value="UNCHARACTERIZED HYPOTHALAMUS PROTEIN HT007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07114">
        <property type="entry name" value="TMEM126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAE1309666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="218" mass="24211" checksum="295F7449A09E3565" modified="2021-09-29" version="1">MISHAKGGKISQVSRYEELPEGAVPISPDDVLLFQLERLKNWKNGSEVWPLTKGAGICAASTVVSGVLTNNHFRKQFNLRYFGRTSGYLMVVCVPTIVTFLLHTTLVTRRILVADFTCPTCLLTKSSILQALNGAVYPSVISPIMCIIQAKKYLTSPIEPTKRIGDTVKVIARTAIPFKGFILLSILSNMAVGMYITRLEMDTFLNVLMKKDKNKELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DTA3</accession>
    <name>A0A812DTA3_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cleavage stimulation factor 50 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SPHA_62207</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004425">
        <property type="protein sequence ID" value="CAE1310649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DTA3"/>
    <dbReference type="OrthoDB" id="14421at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005848">
        <property type="term" value="C:mRNA cleavage stimulating factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.960.50:FF:000001">
        <property type="entry name" value="Cleavage stimulation factor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000064">
        <property type="entry name" value="Cleavage stimulation factor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001234">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:002475">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.960.50">
        <property type="entry name" value="Cleavage stimulation factor subunit 1, dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044633">
        <property type="entry name" value="CstF1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032028">
        <property type="entry name" value="CSTF1_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038184">
        <property type="entry name" value="CSTF1_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44133">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44133:SF2">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16699">
        <property type="entry name" value="CSTF1_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Cleavage stimulation factor subunit 1 dimerisation" evidence="8">
        <location>
            <begin position="7"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="102"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="167"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="256"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="300"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="391"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAE1310649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="429" mass="47926" checksum="D5FD6862D33B044A" modified="2021-09-29" version="1">MADIEAKVRENLYRLIISQLFYDGHQNIATTLATTVRTYPACPPSDRLMKLLQLGLKAEEAQNPQQQVPTEAVTPGTGIDLEYETDVQTISPEAALYETCYVTAHKAACRAGAFHHSGQLIATGSEDASIKILDVERMLAKSATPAEIIAMETPQQTMENHPVIRTLYDHNAEVTSLDFHPFHQILVSGSKDFSVKFFEFSKPSVKKAYKSIQESAPVRCLSFHPSGDYILVGTQHPVLRLYDVNTFQCFVSGNPADQHVGPITSVKWSPNAHLYVTSSKDGDLKLWDGVSNKCINTFKHAHDGQEVCSAVFSRNSKYILSSGKDSLVRLWELSTNRCLIIYTGAGSTGKMEHRSQTVFNHTEDYVLFPDEKTTSLCCWDSRNAERQRLLSLGHNNVVRTIVHSPTGPAFLTCSDDFRARFWYRKANSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DTN4</accession>
    <name>A0A812DTN4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_60112</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004157">
        <property type="protein sequence ID" value="CAE1308202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DTN4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="357"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1308202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="428" mass="50809" checksum="9DB67ECDCBF611DF" modified="2021-09-29" version="1">MSIYLSIYLSIYLSIYLSIYEFDTYFLEKSDRETCLSSAFSELIWIDNLKKKSMNVLQINPFKNINSINFDKQTSIYQSISAGSLSIYLSIYLSIYLSISICSYLSIYLSIYLSIYLFYLFQSVHIYLSIYLSIYLSISICSYLSIYLFFNLFSLSIYLSIYLSIYLFQSVHIYLSISICSIYFKSVHIYLSIYFNLFIHLSIYLSISIYYLSIYFNLFISIYLSISIYIYLSIYLSSIYLSIYLSIYFICFISIYLSSIYLSISMFISIYLSIYLSIYFNLFISIYLYLSIYLSISFLFISIYLSIYLSIYFNLFIYLSIYLSIYLSIYLSISICSYLSIYLSIYLPVSDYSYVSIYILFILSIPLTLSHFLSLSLSIYLSITQRLFFSYIYFSVYPLLYIQSVTFYESVYLIDQTIYLFLTEIPYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DTP4</accession>
    <name>A0A812DTP4_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">[histone H3]-lysine(36) N-trimethyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.359</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SPHA_60141</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.359" evidence="2"/>
    <dbReference type="EMBL" id="CAHIKZ030004163">
        <property type="protein sequence ID" value="CAE1308226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="422362at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140955">
        <property type="term" value="F:histone H3K36 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19172">
        <property type="entry name" value="SET_SETD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1740.100:FF:000001">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1740.100">
        <property type="entry name" value="Set2, Rpb1 interacting domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044437">
        <property type="entry name" value="SETD2/Set2_SET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042294">
        <property type="entry name" value="SETD2_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013257">
        <property type="entry name" value="SRI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038190">
        <property type="entry name" value="SRI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46711">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46711:SF1">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08236">
        <property type="entry name" value="SRI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00508">
        <property type="entry name" value="PostSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="11">
        <location>
            <begin position="238"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="12">
        <location>
            <begin position="364"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="10">
        <location>
            <begin position="1339"/>
            <end position="1372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
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            <begin position="382"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="581"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="696"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="792"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="964"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1005"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1058"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1176"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1315"/>
            <end position="1345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="15"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="382"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="394"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="422"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="587"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="728"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="792"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1070"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1177"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1201"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1228"/>
            <end position="1249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAE1308226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1515" mass="169373" checksum="930B1285CE3CCEB4" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DTR4</accession>
    <name>A0A812DTR4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_60621</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004221">
        <property type="protein sequence ID" value="CAE1308778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DTR4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1308778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="177" mass="21088" checksum="27FE010BA1B242F0" modified="2021-09-29" version="1">MVTPCYIDSYFYLSIYLSIYLSIYLSIYLFVHINFHEERLPSMYRKHVFPPHYQLFYNLVDLLLDPSKPGRRRQHPPIPPLVEIVPPVSIQPTTGNWMTAASVYKPVMSHHYNTVFLCLLSEKTGPRQHLSIYLSIYLSIYLSIYLSSISIYLPRFIIYLYFIIIYLYFIIYLCHIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DWD6</accession>
    <name>A0A812DWD6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_61754</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004385">
        <property type="protein sequence ID" value="CAE1310117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DWD6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1310117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="191" mass="21473" checksum="3D44083F93A7164F" modified="2021-09-29" version="1">MYLLISYVSLSLSICLSICLSICLSIYPDHIKTLNCELSCSVDSLLDLHIILSIYLSIYLSIYLSLFRSIYLSIYLSIYLSIYLSISVSSGLSISYFRSIYLSIYLSIYLSILVSSGLSIYLSISVSSGLSISVTSDLSIYLSIYLSIYLSIYLSIYLSIFKSIKYHLVSSGLSIYQILLKSYIISYVFVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E2U5</accession>
    <name>A0A812E2U5_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7041 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_64644</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004648">
        <property type="protein sequence ID" value="CAE1313512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E2U5"/>
    <dbReference type="OrthoDB" id="6231004at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055469">
        <property type="entry name" value="DUF7041"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327">
        <property type="entry name" value="ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327:SF3">
        <property type="entry name" value="RNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23055">
        <property type="entry name" value="DUF7041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7041" evidence="2">
        <location>
            <begin position="17"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="500"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="524"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="562"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1313512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="575" mass="64713" checksum="CCDEB7003C492A38" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E4F4</accession>
    <name>A0A812E4F4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_65531</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004724">
        <property type="protein sequence ID" value="CAE1314477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E4F4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00303">
        <property type="entry name" value="SECYTRNLCASE"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="317"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="352"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="381"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="413"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="444"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="471"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="499"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1314477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="626" mass="73405" checksum="A47C2B34CEAE8C07" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E5L6</accession>
    <name>A0A812E5L6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_68208</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004953">
        <property type="protein sequence ID" value="CAE1317687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E5L6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="297"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1317687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="386" mass="46203" checksum="9903E56719DBEE35" modified="2021-09-29" version="1">MFFFLSFFLYFFISHSFLLFLYFFVFIIFSLFSFLTVILSLILPPPSFFFFSHIFLFMCRPFALMHSPFLIFQSFLLFFFSLSSPPSNRTLFHLSCFPIIFCGIFNHRLFLLLYVSNFIWENINFTPRRRNKINDVTLRFNLGFDDAAKKRDLSIYLSIYLSIYLSIYLSIYLSIYLSISVRYRSICIHYLSIYLSIYLCPLCIYLNSLSIYLSIYLSIYLSIYLHYYLSIYLSIYLSIYLSIYFCSLSIYLSIYLSIYLSIYLSISVRYLSICIHYLSIYLCPLSIYLSIYLSIYLSIYLCPLSIYLSIYLSIYLSIYLSIYVHYLSIYLSIYLSIYLSIYLSIYVHYLSIYLSIYLSIYVYYISLFSIYLRSLDWVTGILLNDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E641</accession>
    <name>A0A812E641_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_69189</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005066">
        <property type="protein sequence ID" value="CAE1318700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E641"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1318700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="576" mass="63866" checksum="CD2F7C5189B4C0D6" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E655</accession>
    <name>A0A812E655_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_67298</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004876">
        <property type="protein sequence ID" value="CAE1316642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E655"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1316642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="198" mass="21662" checksum="BDD2E1483F7ECFF4" modified="2021-09-29" version="1">MLLQIPIPSYCFFHLHISPHLLLPLSLSLPPLSLSLSVSAFIFFSFLISISLRLSLLSPSPLSPSLPLSPSIPISLFSLSLSAFIFFIFNVHISDSPSSFPLSPPSLSLPPSLSLSVSAFIFFSFLISISLRLPPSSLSPSLSLLPHLSLFLSLYQLFIFFSFLISISLRLSLLPLSLSPHPPLSVSLFLSLSLSFYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E6P5</accession>
    <name>A0A812E6P5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_69474</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM154 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005079">
        <property type="protein sequence ID" value="CAE1319036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E6P5"/>
    <dbReference type="OrthoDB" id="365640at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005879">
        <property type="term" value="C:axonemal microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036126">
        <property type="term" value="C:sperm flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033336">
        <property type="entry name" value="SAXO1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31516">
        <property type="entry name" value="STABILIZER OF AXONEMAL MICROTUBULES 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31516:SF17">
        <property type="entry name" value="STABILIZER OF AXONEMAL MICROTUBULES 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05217">
        <property type="entry name" value="SAXO1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="99"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="175"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1319036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="442" mass="51585" checksum="F8E3729FD7C72D68" modified="2021-09-29" version="1">MVKCICQICVCGRHHCPHRPANITGMGDFPCRLTEYTTNYKEHKLDKGICIRPQGEPLPQGNMEEKTIYRVDYPPHEPKPPCRHLPEVWKKPPGNIDGLTSYKKDYTNKKSKPAPSMRQDARPLNTGKFHGDPTYSTDYKQWELEPRRIPMVKAWSPPTNKMEGKSTFTRDYSYKEPRPAESFKPEPMRPAEGLFDDSTRYRDEYIEHGLPEKSPREKPLYRLPTVPLDGLTTFKRDYQEKNIPQTKNYAPDNTYKIPEEPIDDLTTFRRDYLNWPPSMPTLHQPEPYKKPPGKMDKDTTHKLAYRYFPTPPAQKYMPKTSATVGGKFNDESSYNTDYKPWKVAQLPMRKQEYIPNTAPFKGISTMKAHYVPHPPVETMTCKPESSWEQDKGPLEDNTMYRLDYTPKEAPLCPAIFLDTNMTPYRFIREEETGHRFYTRNGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E8D2</accession>
    <name>A0A812E8D2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_70278</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005139">
        <property type="protein sequence ID" value="CAE1320012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E8D2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="301"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="332"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="362"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="390"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="424"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="448"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="474"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="504"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="536"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1320012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="561" mass="67661" checksum="F999015ECCC6C13F" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E8J2</accession>
    <name>A0A812E8J2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_68760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005016">
        <property type="protein sequence ID" value="CAE1318251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E8J2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="338"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="373"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1318251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="413" mass="50098" checksum="7D823A993732BF4A" modified="2021-09-29" version="1">MCPFLFLACSFSHIFRASLSLSSLSLSLSLSHSRCSSYFLFSQYLFSLYILYSLFSFLTFTAYFIFVSSKRLSFFHCFFNSYCHLRFNFFGYLSYFLFFFFSFSFLFRLFIHYTFFFSFSIFLSFFFSDVDSFLSLLTVTFYLLLLYDFYNLSYFHASCIFPNFYFLTVTFFFVYYSSFLSFLIFFFILIILVSFFFSFLQSFLSFSTLNFILHLFISFILSVFPSFFHSFFPFPLSSTLQFFLSFFLSYHFFLYYLFSFYFFFFLCSSVSFVSALAFDFFLYFFLSFFLSFYVFLFRSILFSYYYCSFCVNFSVYLFSCKFCLSAFLSFFLSLCISFFLYFPLLIYFIFLLLLLFLCYFLRLPFSCKFSFFLFLLLSFSFSFFLSFFLFVCLITLLLSLFSHLLFFLSFVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E911</accession>
    <name>A0A812E911_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_70330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005144">
        <property type="protein sequence ID" value="CAE1320068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E911"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="302"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="337"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="370"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="394"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="434"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1320068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="462" mass="51391" checksum="32C06690F48A1BB1" modified="2021-09-29" version="1">MCSHLRIHYHVMTSQPNLNSPQFLCHCRHVQRIISLSLLLVQSISLLHTHTHTHTHTPSLSLSLSTFLSAFLFISLCLSLYLSLPFSLSLSAFLFISLCLSLYLSLPFSLSLSAFLFISLCLSLYLSLPFSLSLSLSQPFSLSIVLSLSVFVSCSLSLSLALCLCLLLSIFLLLCLFLLLYLALTPTLCFSLSLALSLPLSPFLCLLLSLSPALLFFVSCSLPLSAILCLLLSPSLCFSLSLALSAFLCFLLSFYVSFSPSVSLSLCLLLSLPLSLSLCLLLSLSLFLFVSCPPSLIYFPIFFLYLSCFYSLLFFYSVTFFTFVLFHFFFILCSLPFLSLSALYICLFLKFFSFFVIVSFTHTPYSHHKSLYHIIIINYINHIINIISKHFLSVFVSCSLCLCLLLSLSLSLALSVFVSCSLCLCLLLSLSLSLALSVFVSCSLHGHLFIFVFSNIPKNITS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EAQ2</accession>
    <name>A0A812EAQ2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_71606</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005241">
        <property type="protein sequence ID" value="CAE1321493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EAQ2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="298"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="385"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="419"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="449"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1321493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="506" mass="63216" checksum="35B8D293BFC12A14" modified="2021-09-29" version="1">MVGLKAFPLTVNGKWRCFLIFFSSSFPHSFVPLSIFSFPFLFLIDFHPPNFLFSSKSESFSSLESFYSSASYFFFTKVPSSSSSSSSSSSSSSSSSESSLGSFSTSFSESSSSSLILFLLLLLLLLLLLLLLLLLLRNLRNLLSFFFFFFFFFFFGIFFFFFFGILNFFTIFFFIIFFFFKFFRNFFFRISFCFFFFLFYFFRNVFSFRIFFSGIFLFFYFFYIFFRNFFYFFRSFFSFRIFFSGMFLFFYFFYIFFRNFFFRNFFFRMFFYSFSSIFFRILFFFYFFNFFFHFFRNFFFIIFFYFFFYFFTNFFTIFFFYFNFFRNFFFTIFALHNLILLLLLQLLFQLLQKHLLQNLLLLLQKLLLQNILLQNLRLLFLRWNILLQNLLLLLLLQNLFSYVRIFFRILFLFLSIRIIFFFRIVFFKILFLFFFTILSFKIFFFFMRIFFRIFFFLFIKIFFSSFLLHQNRLFRIFFFIRCFASSSESSSKSYIFLFIKIFFFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EB62</accession>
    <name>A0A812EB62_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_69455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005079">
        <property type="protein sequence ID" value="CAE1319031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EB62"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1319031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="189" mass="22064" checksum="0DFEFC531D757018" modified="2021-09-29" version="1">MKKDINKSFSEGDTDLCSLHDLSIHLSIYLSIYLSIYLSIITNFFLIYLSIYLSIYLSIYLSIYLSIITSLFMIYLSSIILNLSIYLSIYLSISFSLSIPLSLSSLAFCHYLSLSLYLSIYLSIYLSIYLSIYLSIYLSHSLSLSIYLSIYLSISLSLSLYIYIYIYIYIYIYIYISIHPSIRWLRISD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EB72</accession>
    <name>A0A812EB72_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_71733</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005255">
        <property type="protein sequence ID" value="CAE1321646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EB72"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1321646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="335" mass="38299" checksum="B64414427C9C0482" modified="2021-09-29" version="1">MSCALFKFPQTIRHPFTQAIFLCFRCPVRLKFPKPSDIRSHKLSSFCFRCPVRLKFPKPSDIRSHKLSSFCFRCPVRLKFPKPSDIRSHKLSSFCFRSIFLCFRCPVRLKFPKPSDIRSHKLSSLCFRCPVRLKFPKPSDIRSHKLSSFAFDVLCALNSQTIRHPFTSYLPFAFDVLCALNSQNHPTSVHTSYLPFAFDVLCALNSPNHPTSVHTSYLPFAFDVPCALNSPNHPTSVHTSYLPFAFDVPCALNSPNHPTSVFLMLSSFCFRCPVRLKFPKPSDIRSHKLSSFCFRCPVRLKFPKPSDIRSHATCPFPNHPTSVIYLLLLSMSCAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EE80</accession>
    <name>A0A812EE80_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_71447</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005233">
        <property type="protein sequence ID" value="CAE1321335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EE80"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="170"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="206"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="270"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="300"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="340"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="377"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="414"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="440"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="471"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="503"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="535"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1321335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="577" mass="66562" checksum="0D9F185B393FF5BE" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EG50</accession>
    <name>A0A812EG50_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_71931</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005273">
        <property type="protein sequence ID" value="CAE1321921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EG50"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1321921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="171" mass="20730" checksum="12B64C7A1979D4BA" modified="2021-09-29" version="1">MKNKSVYIYLSIYLGYFQSIDLIFFIFFFLSRSISICLYDFQFVLLSFLLSLILSIYLIFFLFFLSLFLSFFLSFFLSLSLSFFLSFFDYFYLLIESFFLGLSIYLSIYLSIYLSIYLFHLYFYFPLLNFFFFPFLCFSFFISFSSSISCCRSYICISYVGIFKLFLNTFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EG83</accession>
    <name>A0A812EG83_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cationic amino acid transporter 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SPHA_74710</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005437">
        <property type="protein sequence ID" value="CAE1325046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EG83"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061459">
        <property type="term" value="F:L-arginine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015189">
        <property type="term" value="F:L-lysine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000064">
        <property type="term" value="F:L-ornithine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097638">
        <property type="term" value="P:L-arginine import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029485">
        <property type="entry name" value="CAT_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43243:SF105">
        <property type="entry name" value="CATIONIC AMINO ACID TRANSPORTER C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43243">
        <property type="entry name" value="INNER MEMBRANE TRANSPORTER YGJI-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13906">
        <property type="entry name" value="AA_permease_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="248"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="322"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="494"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="520"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="548"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="578"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="domain" description="Cationic amino acid transporter C-terminal" evidence="6">
        <location>
            <begin position="554"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAE1325046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="656" mass="72168" checksum="F1DE115CDC45E2E6" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EK22</accession>
    <name>A0A812EK22_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_77060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005503">
        <property type="protein sequence ID" value="CAE1327603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EK22"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1327603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="291" mass="32765" checksum="E1D6507B451EFB54" modified="2021-09-29" version="1">MSSFLLTCQILHAPFLMTCQILQALLSYDVRFSRPAFLITCQILQALLSYDVFSRAAFLITCQILQALLSYDVLDSQTLLSYYVSDSPCPLFSSDVSNSPCPFSYDVSDSPGPPFYDVSDSPGPPFLSRVRFSRLFFLMILQGRLSYDVSDSPGQPFLITCQILQALLSYDVFSRAAFLITCQILQALLSYDVSYSPGQPFLSRVRFSRLFFLMTCQILQASLSYHVFSRPAFLITCQILQVLLSYDVSDSPGQPFLSRVRFSRLFFLMTCQILQASLSYHVSDSPGSSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ELN0</accession>
    <name>A0A812ELN0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_76291</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005487">
        <property type="protein sequence ID" value="CAE1326703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ELN0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="329"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="361"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="419"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="447"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="476"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="508"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1326703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="543" mass="68413" checksum="A02AB2A6AEB8DE57" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EQ20</accession>
    <name>A0A812EQ20_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_77276</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005511">
        <property type="protein sequence ID" value="CAE1327824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EQ20"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1327824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="210" mass="24522" checksum="93F4EBE9223F1C67" modified="2021-09-29" version="1">MPFHHDFLFHFHHIYSYLSIYPSIYLSIYLSIYLSIYLSLLKSINLFHYSFLSLFVSIYLTLFDLSIYLSHYSYLSAIYLLSLSLHIYLTIPFYLSIRIYLPHPICIYLSLFTSISQFVSIYLSIYLSINLSIYLSIYLSIYLSIQKQKIKCSFLFGWGTHSFSISLSPLFISPIYLSPSLFLPITLFLPLPLSLSPLLSFSLTLSFSTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ETP5</accession>
    <name>A0A812ETP5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_76858</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005498">
        <property type="protein sequence ID" value="CAE1327348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ETP5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1327348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="244" mass="28658" checksum="ADF7580219CBD12A" modified="2021-09-29" version="1">MISTVIFKGCFMPCNKRRLLPGVMEATLWSATGRRRNLYFFSSCNVTVSSARERQKTRRRCDVFRFSTTFVLSYLSPCCCRGLVVRWRPSRDRGGQWQHCLWLQRDISKIVHICLPQSVQIYLSIYLSIYLSIYLSIYLSISVYIYLSIIDYLVFLSIYPSIYLSISVHYLSISVHFLSISVYLVFLSIYLSIYLSIYAHIYLSIYLSIYLCLLSIYLCSYLSIIVYLVFLSIYLSIYLSKYSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ETX4</accession>
    <name>A0A812ETX4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_78705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005548">
        <property type="protein sequence ID" value="CAE1329157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ETX4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1329157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="219" mass="25912" checksum="8C2D12962C0D6B6E" modified="2021-09-29" version="1">MQVISIICTIFRSYLIEILSFFLSFFLSFFLSFFLSHSISIYLSYPLISYLFICLPFLFLFSSFSLSLSLSLSLKWNPLIFLLSGINLSQSFPIYLSIYLSIYLSIYLSILVLRSFFSLFLSFFLSFFLFISSFFFLSSFFLSFFLSFPTFFVVLSFLDLFCLFVSFFLSPLCLFVCLFVCFFLSFFLSFFLSFAFSFFFLNNSFFLCLPFILSFFFFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EWI1</accession>
    <name>A0A812EWI1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_80729</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005609">
        <property type="protein sequence ID" value="CAE1331554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EWI1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1331554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="248" mass="29104" checksum="75570C3F2A87D436" modified="2021-09-29" version="1">MPIYSEKHTEPNFNLRSVQRTAEFLSKWGVTDSYSSQGCTRLVSTEVFSYLSIYLSIYLSICVSSFISIFFSIYLSIYLSIYLSIYLSHSIHIYLILFLSIYLSIYLSIYLSAFVHIYVNLFIITISIYLSIYLSIYLSVLVRSYLCKSFIIMISIYLSIYLSIYLSIYPIFSYQYKLNRNGLCLTSSLSIYLSIYLSIYLSISAYFIYLSISLSLSLSLYIYIYIYIYIYISAYLYLSHPIYIYLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AKB5</accession>
    <name>A0A812AKB5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SLC22A15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SPHA_993</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000027">
        <property type="protein sequence ID" value="CAE1142042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AKB5"/>
    <dbReference type="OrthoDB" id="10021984at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="202"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="225"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="132"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAE1142042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="338" mass="38212" checksum="3A47815103DF99E1" modified="2021-09-29" version="1">MLPLKNQFLDEFTNNQHLFISLHPIFIGRRRSWRFWCAPCICNRNYIHEVSIPTSTGNTNWVSCCFCFDFSDRVLHKSLETINDRHLSTINTIGIINDMACPRVAPLVDESEHGIEISKSNNRNVKLWKIFTVRALLKKTLVMMFNWGTMIFVYYGLTLNIGVLAGNVYLNLVLNSIVEISVILFAVIVVDRFGRKKLTLSFMAISGITGILTLFPYLYASKDQYWTITALTTFSRMCVSGASSIIYLYTCELYPTCIRNSSVGFFGAFARVGGVLSPYIMDISSLVPGRVGKSLPLMLMGITCFVSGILLIFLPETTNKPMQDTLDELTKSKHTNNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ALD6</accession>
    <name>A0A812ALD6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_1592</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000045">
        <property type="protein sequence ID" value="CAE1145231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ALD6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1145231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="195" mass="22249" checksum="3E0AEA79A8ECBB15" modified="2021-09-29" version="1">MEKKRIPCSFSFFLSFFLSFFLSFFLSFFLNKASILLSTTPPCIPSFIHSFLSIYLSIYLCSINIYLSIYLSIYLSIPVYLYLSIYISIVSFDIYLSIYLFTSSYLYTSIILVCYLSQCFYLSIYLFTLNQTSPSSAIAATVASLKKPARTFHRLVTFLNPSNSILSISLLTSATKCKPASLKFDSLLDSYVVIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AQN3</accession>
    <name>A0A812AQN3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="23">FAT4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">SPHA_3749</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">Farmed</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Cadherins are calcium-dependent cell adhesion proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Cell membrane</location>
            <topology evidence="1 16">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000113">
        <property type="protein sequence ID" value="CAE1153155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10071831at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016342">
        <property type="term" value="C:catenin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045296">
        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000020">
        <property type="entry name" value="Dachsous cadherin-related 1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000116">
        <property type="entry name" value="Dachsous cadherin-related 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000031">
        <property type="entry name" value="neurogenic locus notch homolog protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000109">
        <property type="entry name" value="Notch homolog 4, [Drosophila]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000123">
        <property type="entry name" value="Protocadherin beta 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.900.10">
        <property type="entry name" value="TCF3-CBD (Catenin binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039808">
        <property type="entry name" value="Cadherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000233">
        <property type="entry name" value="Cadherin_Y-type_LIR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027397">
        <property type="entry name" value="Catenin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013032">
        <property type="entry name" value="EGF-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027:SF438">
        <property type="entry name" value="CADHERIN 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027">
        <property type="entry name" value="CADHERIN-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01049">
        <property type="entry name" value="CADH_Y-type_LIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12661">
        <property type="entry name" value="hEGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 14 16" id="KW-0106">Calcium</keyword>
    <keyword evidence="9 16" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 15" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4 16 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="247"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1089"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="22">
        <location>
            <begin position="278"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="22">
        <location>
            <begin position="367"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="22">
        <location>
            <begin position="468"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="21">
        <location>
            <begin position="641"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="21">
        <location>
            <begin position="680"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="21">
        <location>
            <begin position="717"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="20">
        <location>
            <begin position="754"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="21">
        <location>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
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            <taxon>Mollusca</taxon>
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            <taxon>Sepiidae</taxon>
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                <person name="Bekaert M."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
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</entry>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1102"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1152"/>
            <end position="1171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1173546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1210" mass="139347" checksum="7D3F0B5414D60FEF" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B9W5</accession>
    <name>A0A812B9W5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_13543</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000457">
        <property type="protein sequence ID" value="CAE1175279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B9W5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1175279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="161" mass="19162" checksum="04301B1D0FDC8D6A" modified="2021-09-29" version="1">MFSFVFNPLSCFLLRLLIYSPYLFLIFFLRHFTSPFTLSLSPFSLSFCFFYINFFLLPSPFFFLFPSFFIIFFHLFSPSFSIFPPFFLLFSSSFFSLLLHFPFLFSFFFHHLFSSSFFSLLLHFSFLFSFLSHHLFSPSLSIIGITSHFSGGMHLLRISRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BAH4</accession>
    <name>A0A812BAH4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_12145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000403">
        <property type="protein sequence ID" value="CAE1172578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BAH4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1172578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="342" mass="39745" checksum="45B5A7304F2A3A28" modified="2021-09-29" version="1">MVSKCVSIWISSSRMLGMVAVFPPDQPPLSLSLPLSLYLSLSLSLFLSLSLSLSLSLISLFLSLSISLFSLSLFLPLSLSLSLSLSFSFSLFSFLFLSLSFSFFSPLFSLSFFLSLSLSLSLPLSLFLSLSLSLSHTHTHTEAGSFLSFPFFLLPFPSIIFSLFLLPVPSLFFLFVLSFFLFVPFAFCFSSRFFFFLSVFSSFFSFFFFFLFFSLFLLTVLSLSFLLSFLPFFLSFFPSFFLSFISFFFFLLLSFFSLFPSFLRSSVPFFLSFVCFFHFAAFFLFFLFFLSHFGSFFLFVFFFFALLFFFIFVFFPFYLFFLNSFFSFFFLSFFSLFLFAIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BCS3</accession>
    <name>A0A812BCS3_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thyroglobulin type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SPHA_14392</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000491">
        <property type="protein sequence ID" value="CAE1176952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BCS3"/>
    <dbReference type="OrthoDB" id="1725934at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00191">
        <property type="entry name" value="TY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.800.10">
        <property type="entry name" value="Thyroglobulin type-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000716">
        <property type="entry name" value="Thyroglobulin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036857">
        <property type="entry name" value="Thyroglobulin_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00086">
        <property type="entry name" value="Thyroglobulin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00211">
        <property type="entry name" value="TY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57610">
        <property type="entry name" value="Thyroglobulin type-1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51162">
        <property type="entry name" value="THYROGLOBULIN_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thyroglobulin type-1" evidence="3">
        <location>
            <begin position="119"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAE1176952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="236" mass="27116" checksum="E3C15619950F2C8E" modified="2021-09-29" version="1">MDILDTRWLFHTPTSSYPHFFKQSVICYCPFRREFYHEDRDSFCFDTCSRINCRSVTACNGRISKGLCGCCDVCIVTLREGEVCNPYPFLGLPPHSECGFNLVCSKHTMTCIKPLNLFVDKCNEERSKAMLKMLPGAFLPRCSADGSYAPVQCRGSVCKCVTKDGEEINGFQGRIHDNDMNCNCARDQSDYQKEQLLDWLFWSSHQQNKLAQLLDKRRLPKPQMTDDFLVLSNKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BDN5</accession>
    <name>A0A812BDN5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DKC1</fullName>
            <ecNumber evidence="6">5.4.99.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SPHA_15477</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Farmed</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase TruB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="6"/>
    <dbReference type="EMBL" id="CAHIKZ030000538">
        <property type="protein sequence ID" value="CAE1224641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BDN5"/>
    <dbReference type="OrthoDB" id="10250002at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000495">
        <property type="term" value="P:box H/ACA sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031118">
        <property type="term" value="P:rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02572">
        <property type="entry name" value="PseudoU_synth_hDyskerin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21148">
        <property type="entry name" value="PUA_Cbf5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2350.10:FF:000001">
        <property type="entry name" value="H/ACA ribonucleoprotein complex subunit CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012960">
        <property type="entry name" value="Dyskerin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004802">
        <property type="entry name" value="tRNA_PsdUridine_synth_B_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032819">
        <property type="entry name" value="TruB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004521">
        <property type="entry name" value="Uncharacterised_CHP00451"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00425">
        <property type="entry name" value="CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003280">
        <property type="entry name" value="PRK04270.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00451">
        <property type="entry name" value="unchar_dom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23127">
        <property type="entry name" value="CENTROMERE/MICROTUBULE BINDING PROTEIN CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23127:SF0">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT DKC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08068">
        <property type="entry name" value="DKCLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16198">
        <property type="entry name" value="TruB_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01136">
        <property type="entry name" value="DKCLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dyskerin-like" evidence="5">
        <location>
            <begin position="38"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="PUA" evidence="4">
        <location>
            <begin position="287"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="415"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="440"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="459"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="483"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAE1224641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="496" mass="56071" checksum="9492A873484594D4" modified="2021-09-29" version="1">MGENIKKKKKKMSESNIADIQHSSSFSVAPSDHGEKLDASDWPLLLKDVDRLNIRTNHFTPIPCGCSPLQRPITEYVGCGFINLDKPSNPSSHEIVAWLKRILRVEKTGHSGTLDPKVTGCLIVCIERATRLVKSQQSAGKEYVCIFKLHSVVEEEKKVIQCLERLKGALFQRPPLISAVKRQLRIRTVYECKMLEYDKENAFGIFWVSCEAGTYIRTMCVHLGLMLGVGGQMQELRRVRSGIQSEKSGMVTMHDVLDAQWLYDNHKDESYLRRVIKPLEALLVSHKRIILKDSAVNAVCYGAKIMLPGVLRYEDGIELNEEIVMVTTKGEAVCLALAQMTTAVMATCDHGVVAKIKRVIMERDTYPRKWGLGPKAAVKKEMISKGLLNKYGKPNEKTPEKWLELLYSLKPEVKEEFPPRKRKREAGSSSEEEPVAVSSVKEESGDEQKKKKKKKKKKAALEEEKKASPEEETATESTETPVKKKKKKKHKEEKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BHJ0</accession>
    <name>A0A812BHJ0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_17504</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000624">
        <property type="protein sequence ID" value="CAE1229874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BHJ0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033010178" evidence="1">
        <location>
            <begin position="24"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1229874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="367" mass="39424" checksum="00712D424622D166" modified="2021-09-29" version="1">MFSKSLVSLSFLSVSLLFSLSLSDSSICLSVASSVSLSLFMIHYSFPSIRVASSSLPLSELHLPLSLYQSCIFLSPSIRVASSSLPLSELHLLSPLSELHLPLSLYQSCIFLSPSIRVASSSLPLSELHLPLSLYQSCIFLSPSIRVASSSPSIRVASSSLPHQSCIFLSPSIRVASSSLPLSELHLPLSLYQSCIFLSPSIRVASSSLPLSELHLPLSLYQSCIFLSPSIRVASSSLPLSELHLPLSPSELHLPLSLYQSCIFLSPSIRVASSSLPLSELHLPLSLYQSCIFLSPPSPSLHLSPPLPLPPSPPPSPPLPPLSPLPLSPTLPPLPSLPSVFNLFPFCFSFSLSLLHFSYFSSLSSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BIU5</accession>
    <name>A0A812BIU5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_17490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000624">
        <property type="protein sequence ID" value="CAE1229854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BIU5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1229854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="153" mass="17877" checksum="B1E6207E09FC927C" modified="2021-09-29" version="1">MIMFIIKCASVFLRRGMDLSLTDDSTANKQNRHNRIRILTELICVHSNITTFSSQIRAAGTISLISIYLSIYLSIYLSIYLSIKHCPNICSLSISIYLSIYLSIYLYYHPQTDCFAWLAWGDTYQKSIYLSIYLSIYLSIYRRINYKAEIFFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BN01</accession>
    <name>A0A812BN01_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_19592</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000711">
        <property type="protein sequence ID" value="CAE1235006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BN01"/>
    <dbReference type="OrthoDB" id="2384430at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052748">
        <property type="entry name" value="ISR_Activator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45011">
        <property type="entry name" value="DAP3-BINDING CELL DEATH ENHANCER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45011:SF1">
        <property type="entry name" value="DAP3-BINDING CELL DEATH ENHANCER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1235006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="515" mass="58313" checksum="317B677A105E5988" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BQU6</accession>
    <name>A0A812BQU6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_25172</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000953">
        <property type="protein sequence ID" value="CAE1246484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BQU6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="317"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="351"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1246484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="378" mass="44292" checksum="CDE15615E809FABB" modified="2021-09-29" version="1">MCSYLSIYLSIYLSSSFHIYLSCPLCSSLSILLCVSIYLYIYLSIYLIVRIYLSIYLSLAISIYFICLSVSLSIRIYLSIYLSIYLSYCSYLSIYRSIYLSLAISIYFICLSVSLFVSIYITVRIYLSIYLSILLFVSMYVSSYVYIYLSIDLSICQSVAIYLSVCHLFISFLFIYHGYSYLSPFIHIYLSIYLSIYLSIYLSISIYLSLFISIHLFITAIHIYLSISVYSYLSIYLSIYLSIYLSIYLSISVYSYLSIYLSRLFISIYLSIYLSIYLSIYLSPFIHIYLSIYLSIYLSIYLSQSIHIYLSIYLSRLFISIYLSIYLSIYLSISVYSHLRLSIYLSIYLSIYLSIYLSIYLCLHLSVCLSIYLSIYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BSE2</accession>
    <name>A0A812BSE2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_21887</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000805">
        <property type="protein sequence ID" value="CAE1239607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BSE2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1239607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="201" mass="23228" checksum="3B9A99EA94F10A57" modified="2021-09-29" version="1">MIHSQISLVSVLHVNMKLTKHLLFLIHPSSSSFSSSPSFTIFLLIIFLLFSLFSFCTSPFSPRPSHSFLLLLLLFLLLLLLLLLLLLLLIIIIIIINVFLMETRFLAILQNVFTSHFFFVFFFSHHSLIYFLSLNVFPIIYHFFLFAFPPFALKPFPFLFLNAFVFSIICSYIVVVVVVVVVVVLLLLLLLLLLLLLLIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BTP2</accession>
    <name>A0A812BTP2_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein rogdi</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_23840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the rogdi family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000884">
        <property type="protein sequence ID" value="CAE1243481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BTP2"/>
    <dbReference type="OrthoDB" id="66510at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043291">
        <property type="term" value="C:RAVE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028241">
        <property type="entry name" value="RAVE2/Rogdi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13618">
        <property type="entry name" value="LEUCINE ZIPPER CONTAINING TRANSCRIPTION FACTOR LZF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13618:SF1">
        <property type="entry name" value="PROTEIN ROGDI HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10259">
        <property type="entry name" value="Rogdi_lz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1243481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="275" mass="31790" checksum="FCCD20B4252C2A0B" modified="2021-09-29" version="1">MMADADLDEEISALRKELNWLLNEELQHVLQQVQYTLAECSQRFLTEKDKESEESNFSCIKPQRILLSGPNGASHIRCVLTLHGDNITEADINFKHKQGNHHSLFKTSIHQSLPWKLQQIQDASNHLRCAAFCISTKDDYAFKSVREVTLFLDEVMESIKKGRTCLTFPRRKSVEELLNNQNMQVFQPSIPNSVSLSFYIHTSKLILALYQLHHNAQLQKMEVSARHQVECTVKWLNEAVMLFTLAIQQIQQLKDKFQALQCFEELENYVNEGPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BUU2</accession>
    <name>A0A812BUU2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_23209</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000858">
        <property type="protein sequence ID" value="CAE1242227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BUU2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1242227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="178" mass="21229" checksum="54DEC763FD7C6F82" modified="2021-09-29" version="1">MFHLLIYTFNARVWCFFVSFSDFVYFSVIAISLVIIYLLFIFIYLVISIYLVISIYLSIYLSILSYLSIYLFISIYLSIYRTLFSYLSIYWVISIYQTLWSYLSGHYISICSSLPISFWTLLYISLSFCLSPLSLLLYTRLILCRDYNLFHIKHLLHLPLSISPLSFFSLFFISRSLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BWC1</accession>
    <name>A0A812BWC1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_23336</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000864">
        <property type="protein sequence ID" value="CAE1242544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BWC1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1242544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="322" mass="37597" checksum="4F74154D81E8F642" modified="2021-09-29" version="1">MLNLFPLSLFLSIYLSIYLSIYLSILIMSNLFPFYIYLSIIYLSIYLSIYLFSLCFNLFPLSLFLFIYLSIYLSIYLSILIMLQFIPILYLSIYSSIYLSIYLSIYLSILIMLQSIPIKFISIYLSIYLSIYLSIYLSIYLCIYLHYAPIYSHFISIYLSIYLSIYLSIYLSSLCLYKSILFLCLSLCLSVCLSLSLSLYIYIYIYIYYIYICIYLSIYLSIYLSIYLSILVLIYFQFLYEFLTVPYLSTLPPPPDFFCVGPPCANITPLPLAPAYAGEKKNKTSHCNLQRFIIAGKIYLSIYPSLFLTLSLSLSLSIYLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BWD6</accession>
    <name>A0A812BWD6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_24035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000891">
        <property type="protein sequence ID" value="CAE1243895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BWD6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1243895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="335" mass="41507" checksum="D8C260D58A13CDEC" modified="2021-09-29" version="1">MYPYTCSHFFFLLFANFTILAFPLLFFFFFFLFYFPSFFSLLSISYHSFLSSFLYLPLFFFSSFLFTLFFFFFAFHFFFLPFFPFLYFSFSSSFLFHLLHSFLFSSFLSFLLFPLFLFYNYFSCFSFLTIFCFLLIFFLLLFFLFSFFPLFFFFHSSLFYYFLKIFPLLSFLFTLLFSFFRLFLLLCFFLFCFPFLTILSFRLFYSFLFSSSIFYFSFLSISYNSFFSAFPFHPLAFLTYLFSFFILNLWLSFHYTCYLSRFLSFVFFLLFFFLFFLIISFPLYPICYNIFRIFLFFSTFVVLPFRFFFFCIFSNYFWICICASSICLLSNHVFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BWJ7</accession>
    <name>A0A812BWJ7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_25410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000962">
        <property type="protein sequence ID" value="CAE1246964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BWJ7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1246964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="274" mass="32408" checksum="67483CD2BE0A5215" modified="2021-09-29" version="1">MKTEQVSLSYYFFFSNRIFIFSLCLSLSLSLSLSLSLSLSLSVSVSLSLSLLEFLNDFFLFRFQHFLFLFPLPLLLIFAFLIDGPFGFFFSLLPFSRFLINFPSSHFPILYFFSRHLLFPPFPPLSLYIPFFLFLFLPFFLFLSLFLLLALFPSSFLSLSLFFLSLSFFIYFSLFFLSLSFFIYFSLFFLPFFLFISLSLSLFLSLSLSLFLSSFFLSLFLHSFSFSLSLSFFSFLSFLFFLSFPWVLLSPVFLIFHTFFLQCEFFFYSNVHSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BWT7</accession>
    <name>A0A812BWT7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_24983</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000945">
        <property type="protein sequence ID" value="CAE1246092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BWT7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1246092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="276" mass="31137" checksum="0004D4E4934B29A6" modified="2021-09-29" version="1">MSLFLSHTFYLFLSFHFSHLLCFSYPVFQCISISFLLLFLFLTLSLCQSISFFLFFFLPVYYTYFIILFMTFSLFQSLSHIKHILSLSLFLSVNLSLFQFFLFLPSLSFILYLSLLLSVSLSLSTLLFLYLSQFVCLFVSLSLSIPLSLSLSFTHKTHSLTISLCQSISVSISVSLIPALSLSLIHFISVSFTFSFSLSLLASLCLYCSLCLSFFFSLSLFLFLCQSLSHSLFLSLSLTPPLSHSISTSLAHLFNLSFSSSVCLPVCLPVSLDKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BYN0</accession>
    <name>A0A812BYN0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_25222</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000954">
        <property type="protein sequence ID" value="CAE1246521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BYN0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1246521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="281" mass="30799" checksum="3E929F5BA7301284" modified="2021-09-29" version="1">MHSTNQIVFGCVATCIKLFGRPLKRPRKKTATVAATTTTPCGNTKSRCHIWTHHCQIAHLTGCFLLLCLRLHRQPVPGAGCPESEQLPSANVARVRTAPKRKRCPSPRVQTAPERKRRPSPCVQTAPERKRRPSPRVQTAYKRKRRPRPRVRTAPKRKRRLSPNRSRAQTSPKPPSPNSAHAQTSPKPPSPNCSRAQTSPKPPSPNSAHAQTSPKPPSPNCSRAQTSPKRKRHPSPNSSLAQTSPKPPSPNIAQVQTSPKPPSANVAQAPSSRIRTAVTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BYU7</accession>
    <name>A0A812BYU7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_25322</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000957">
        <property type="protein sequence ID" value="CAE1246714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BYU7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1246714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="268" mass="31652" checksum="FE3019F862EF3D32" modified="2021-09-29" version="1">MSTSLNISALFTLGYNSHFSFNFTRALFIILFIIYNRVLFTLLFIIYTRALFAILFIIYTRALFTLLFIIYTRALFALLFIIYTRALFTLLFIIYTRALFALLFIIYTRALFTLLFIIYTRALFPPLSLYTLGHYLLSSSLCTLGHYLHSSSSYAFWYKLLSSSSYTLGLIYSHLHYIHSGITYTNIIIYTRTLFTIGHYSHYSSLFTLGRYLHIIIHAIHHYMHSDIMYTHDPYLHAGIIIFTWTLFTPIINIFFLTLFTLPHHYLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C057</accession>
    <name>A0A812C057_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_25905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000986">
        <property type="protein sequence ID" value="CAE1247918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C057"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1247918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="401" mass="45674" checksum="B5CD41B162F3EB9B" modified="2021-09-29" version="1">MRTKFEDSCDDLYNTRPGKKPWDLGRKYTLYSTRLIKTKILSTIVNIIFFFFFFFFFFFFFSASSYSPFPPPPLLFLLLLLLLFFFPPPPLLLLLHLLLLFFFFSSSSASSYSSSPPPPLLLLLLLLFFFSSSSSSPFSTPPPPLLFLLRLFLFFFPSSSSSSSTPPPPILLLFLLLLLLFFFFFFFSSSSSSSFSSSLPLLHLLFLLLFFLFFFSAKIYDFYLMEQSKSKKDVLNLFYIYLSIYLSIYPVCSYLHIFLFISIYLSIYLSYQVDLTLRSIETKPSTDSISVPRGTNNADTGNVVNTCQSVNTYVPSRGPIRQELTRFLPVGRSRTGDDVQPVVRHSHMVGRVSERRWTKFMVISQPASVRRDGDASAAGTAAGGRAPTARLMVHPSNSLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C0H4</accession>
    <name>A0A812C0H4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ArgH</fullName>
            <ecNumber evidence="5">4.3.2.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SPHA_27134</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Farmed</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.1" evidence="5"/>
    <dbReference type="EMBL" id="CAHIKZ030001043">
        <property type="protein sequence ID" value="CAE1250482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C0H4"/>
    <dbReference type="OrthoDB" id="2561043at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004056">
        <property type="term" value="F:argininosuccinate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:L-arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01359">
        <property type="entry name" value="Argininosuccinate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.40.30:FF:000001">
        <property type="entry name" value="Argininosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.200.10:FF:000002">
        <property type="entry name" value="Argininosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029419">
        <property type="entry name" value="Arg_succ_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009049">
        <property type="entry name" value="Argininosuccinate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00838">
        <property type="entry name" value="argH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814">
        <property type="entry name" value="ARGININOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814:SF1">
        <property type="entry name" value="ARGININOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14698">
        <property type="entry name" value="ASL_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00145">
        <property type="entry name" value="ARGSUCLYASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarate lyase N-terminal" evidence="3">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Argininosuccinate lyase C-terminal" evidence="4">
        <location>
            <begin position="190"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="289"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAE1250482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="362" mass="39812" checksum="8769A9862475C419" modified="2021-09-29" version="1">MLQRDLERLMEVEKRVNKLPLGSGAIAGHPFNVDREFLAKELGFAEITGNSSDSVSDRDFILEFMFCGSMVSTHLSRWAEDLILYCTKEFNFVHLSDAYSTGSSLMPQKKNADSLELIRGKSGRIFGYCSGFMMTVKGTPSTYNKDFQEDKEAMFEVYDTLTGILQVATGVLSTLTINKEKMYEALSPDMLSTDLAYYLVRKGVPFREAHSLSGKCVALAENKSCLLTNLTVKELKSVCDHFDDDVQEVWNYTNSVEQYNCNGGTGKKSPGVDSSDVICSQSGVDSSDVIRSQSGVDSSDVIRSQPGVNSSDIIRSQPGGDLSDVIRSQPGVDSSDVIHSQPEVDKFDSLSPILSLVLTRPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C0J9</accession>
    <name>A0A812C0J9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_27541</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001073">
        <property type="protein sequence ID" value="CAE1251511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C0J9"/>
    <dbReference type="OrthoDB" id="8052860at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327">
        <property type="entry name" value="ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327:SF3">
        <property type="entry name" value="RNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="375"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1251511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="419" mass="47822" checksum="0CDF84069907F574" modified="2021-09-29" version="1">MSAAVAPFPLFHEGNIKNWFLQMEAIFTVSLLVSNPSKFGHVVAVLPPAIVDEVSDFLEAVPEDSLPTPSLYEKPTRQKNTMADSILKSLWLDRLPTTITQILAPMSENTSIDQLADAADRIFSQLDNQTMPVHSAEATRDHSSLEKTVEDLQRQVKDLTLAIESHGRSRFPSRRRFRSRPRSSSRNKDATPTMCYYHRRFGSAAHYCTKPCSYTAVAGKQNRQRVKATNLAGKAFSPKLSRLFYVTDTRNNLRFWLTPALPLVSYPCVIKHVNNLFSSAYKQQMVPDLRLKMANLCYTPPRHCPSDIYLPHQLKDCEFVFVRNDSVKRPLTPAYTGPYRVLKRADKYFQIQKGIHTDNVSIDRLKPAFIEKPSSHTTSQSTPQVQENFKTPVSLDKPKYTSSGRKVTFPKKFETFYYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C3P1</accession>
    <name>A0A812C3P1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_26525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001013">
        <property type="protein sequence ID" value="CAE1249305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C3P1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1249305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="260" mass="30543" checksum="94D3D870213601CC" modified="2021-09-29" version="1">MFLSSSSSSSLSLSLSLSLSLSFYCSFDFPPFSSFYPYYESFILRCFFLTVIHIANPFFFFFLLLTLFRLRKLLFLSSLRLFILRNRSSFSFSLKVIHLAKPFSFSLKVIHPSKPFSFSLNVIHLAKPFSFSHNLIHITKPFFFFLSPLTLFILRNLSLSPLKLFILQNIFFSFSLNVIHLAKPFFPFSLNVIYLAKLFFSFSLKVIYVTKAFFFFLSPLTLFILRNLFLFPLTLFILRNLSFFPSPLTLFILRNIFFLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C514</accession>
    <name>A0A812C514_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_28419</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001113">
        <property type="protein sequence ID" value="CAE1253406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C514"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1253406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="226" mass="27402" checksum="BAACD19C46842B52" modified="2021-09-29" version="1">MVPFFDVCSISSTLKVPTPLTALVVFFLSFFLSFFFFHFSFFLSFFFLSFFLSFIFLSFFLSFFFLSFFLCFLYLFSLLSYLSLPFTLSNNNKIIRTSCKTSSRFSFCISNIFFLFFFLSLFLSFFLFYFFLFLVLSFFFFLSFFFIFSSFSFFLSFSFFLSFLFFPLSFFLSFFLSFFLSFFLSFFLSFFLCSLRSWRSTFNLKRKFAFVLFVFDFNGLKDKNFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C538</accession>
    <name>A0A812C538_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_27875</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001093">
        <property type="protein sequence ID" value="CAE1252201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C538"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032701417" evidence="2">
        <location>
            <begin position="26"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1252201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="309" mass="34690" checksum="6FB097C8AECC3867" modified="2021-09-29" version="1">MLFRYFCRKTLILLCITFNICLANGSDEENRKKRQWSKSTINYTDAFQTPTSITTGTSADFTSNHRLSSKRFISKPKNERDLEAFTSKKIKNQPQVNSINRERSNLEHSKGSSANEMASSRDDTEAEFNHIKRDTGLNNYPNVTADSSTGSHSNIEASLSNTKTAQLADNGDQISSNAWPQPIETGSGLSGGNDSEILEWTDSTPVSLVSGETSPSAVKNEELSTYQLHSFETTKPLNISADHTSPIFRTKHPDETEASSVGQSSISGWNWSFPASSYQNYRRSEIIFFRCYTNARNRKRIITSKKYYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C5G1</accession>
    <name>A0A812C5G1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_28658</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001123">
        <property type="protein sequence ID" value="CAE1253868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C5G1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21698">
        <property type="entry name" value="PROTEIN (PUTATIVE)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21698:SF4">
        <property type="entry name" value="PROTEIN (PUTATIVE)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1253868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="208" mass="24236" checksum="B33B1E08F14C55F6" modified="2021-09-29" version="1">MATENLIIISFFCLSIYLSIYLSIYLSIYLSIYLSISVCSYLSIYLGVFLSIYLSIYLSRCVRTYLSIYLSIYLSIYLSIYLSMLVCFYLSIYLSVYLGVFLSIYLSIYLSIYLGVFLSIYLSIYLSIYLSIYLSIYLSVYKPIFDFKSNQSIKNDYRILIGTKIKVNVSHSSNIDIFHKIIVDGKINEDRILDIDAMAKDLLIYFFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C5P8</accession>
    <name>A0A812C5P8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_30551</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001226">
        <property type="protein sequence ID" value="CAE1257036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C5P8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1257036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="222" mass="26628" checksum="DECCD6AF632D2416" modified="2021-09-29" version="1">MSGKIHFLPCSRLCSIPGYSPGLLILRNFFLSFFFLSFFHSFFPFFILSHFPNFFFLSFFSFFVVSQILYSFFLSFFILSHFLSFFLSLFLSFFLSSFLSFFLLFVRSPVLSSSFHSFFLLFFSLSSLSHVLRSFFLSFFLFKFFSFFHSFFPFSFFRTLFISFFLSFFFYTFARFEFFLSFFLSFFRFFPSLFLSFASLLTARPTNVIASLPWGPTLRFYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C6P9</accession>
    <name>A0A812C6P9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_29303</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001165">
        <property type="protein sequence ID" value="CAE1255024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C6P9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1255024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="245" mass="28958" checksum="4E7480D4504D8316" modified="2021-09-29" version="1">MNTDIRHDCSTKVPVSLTVDRSTCSSYHSLFFYHCPFFSLSRFLFSFPFFFLTQIRFHTLSAVTEIYTFFLSLVFFFLSFFLLLYTVQSNTIQLQQVYTLSSSLWLSSFFLSFFLSSLHNSACNRDIYFLPLWFSLFFKRSLYSQRTNSFASSVINNAGYRLQFGVIELKYMFLYFLSGVAWDESDKFHHYQMSLIFPFISYQRFDFESCSFKDKTATDSNFLTLTCPAFWREFQLTPVLCLASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C7Q5</accession>
    <name>A0A812C7Q5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_29980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001202">
        <property type="protein sequence ID" value="CAE1256033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C7Q5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1256033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="248" mass="29339" checksum="3CE0190D679363DC" modified="2021-09-29" version="1">MPNPKMVRYITLSIYLSIYLSIYLSIYLSIYHGLSLSVPLYPSRAINLYSLFMFKSVLISIYLSIYLSIYLSIYLSIYVCLSSIYLSIYLSIYLSIYLSISISSLSIYLPRYYCNNCIIISITNNSNTKRNDLRISIRLYAYLSILNNFSPPLYLLLNLTLFDSLFHFIYLSIYLSIYLSIYLSIYLSIKFLKKNFVFFSYLSIYLSIYLSIYLSIYLSIYLSLFHIYLSIYLLPVFYVCVRLDVYRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C7T2</accession>
    <name>A0A812C7T2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_30093</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001209">
        <property type="protein sequence ID" value="CAE1256289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C7T2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1256289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="259" mass="30834" checksum="346E446551F844BA" modified="2021-09-29" version="1">MKSLLISIDELLADGVDWERLICVAARNVNQRKTYFFQSVASYSFYSYITLILLIIYLSIYLSIYLILFIFYLLYISAHISSSFLFLPLLLLPTFFSFIVFFFNLFYLSLILSFFSFNFIHFFFAISLLFNVIHYFSLLSVFLLLLLLTFPYLSIYLSIYLSIYLSIYLSVRLFRSIYLIPVYRAISLSFYLCLFRSYLSIYLSIYLSIYLITSIYLCIYLSIYLSIYLSHSVTHLSIYLSIYLSISEKCFIYFKLTFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CAA1</accession>
    <name>A0A812CAA1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_31217</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001273">
        <property type="protein sequence ID" value="CAE1258391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CAA1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032418069" evidence="2">
        <location>
            <begin position="36"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1258391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="284" mass="32482" checksum="F9E0381A3E0EA0E9" modified="2021-09-29" version="1">MFRQPPHPSFSSYSFLRPHLSLLFFYFLLSPPTTSFSTCTSLFLNSSPLPSTFSPHTPSPVSTYFLLFFLFLHNLSTLTSPHFFLPAYPLPPIFFAYPPTTTSPSHLPPTFASFPHPPPTSFPHLSSISSFFFYIRRLLLSFFYIFLLLLHLSIFPSSYYYYFPTPSSYFSSFPQLPPTFPFSLYSPTITSPHSLPATTISLLFHPLLLLLIVTNILLLLRLSQHSPPHSLFLLLLLLTTTILSLPSSSFSHPFLPFYFPHFLLPLLLLLISSSNYYLFFHTPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CAD2</accession>
    <name>A0A812CAD2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_32268</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001338">
        <property type="protein sequence ID" value="CAE1260590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CAD2"/>
    <dbReference type="OrthoDB" id="6144264at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1260590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="370" mass="42245" checksum="E0434F67D597701E" modified="2021-09-29" version="1">MPEAAKPSTTKSKPYLQLKSRTEKQCGRMLVPPNLRHQRDTTHQQIRLETYLIPTSSGKWRHHRNLWDQGAYTNWSFTVADVKTPLLGADFLAHYNLAVHMKARTLSDNTTSIKITGIPSSFNTTRISVATQHDPRYVEILRRYKHLTQPIKPTDAGDHQTQHHIKTTGQPASSRPRRLPPHKLAYAKKAFEEMLADNIIRPSDSPYASPLHLATHCPLSSSTKGDSLSFIFNHKRRLTVLYFQPLKATHCPLSSSTKGDSLSFIFNHKRRFTVLYFQPLKATHCPLFSTTKGDSLSFIFINKRRLTVLYLQPQKAIHCPLFSTTKGDSLSFIFINKRRLTVLYLQPQKATHCPLFSTTKGDSLSFIFNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CB95</accession>
    <name>A0A812CB95_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_32897</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001369">
        <property type="protein sequence ID" value="CAE1261523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CB95"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="320"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1261523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="349" mass="40219" checksum="37C429D5A671C6BF" modified="2021-09-29" version="1">MLSLRIKARNFVATDTTKGPYQTLGTLSNVVVASYSILFCFPLYFRILIFPLFYTSFSSFLFLIIFNGLFFLSSFPLRVLLFSFSRPLSSFLMHLSFLFLSFSLHTSSFTSLTSFSLSIRARRYTTLKSLLRQMLIHLYINNQFSLSPHLYLSLTLSFSHYLTPPLSLSHTHTLSLSRSLLLYLSLSYSLAFESFIFFTPVFSLILSFFPFSPFPPALALHLTFFFSPLIFSCLKPSSFAFHISSSFSLTLHLTLLPSAISHSHLFPLPFPVFDLSPASFVLSFFFLSSFFLSFYAYLFIAFHRLDISFHLPMLTVSDFLFFLLHTYSFFSIFFSFFILSFFSFSSISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CC79</accession>
    <name>A0A812CC79_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_31567</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001300">
        <property type="protein sequence ID" value="CAE1259142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CC79"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="322"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="359"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1259142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="474" mass="55606" checksum="E0F369531DBDCBC0" modified="2021-09-29" version="1">MGSLYFVLSFLLSFFLSFFLSFFLFLIFFQFFHFLSFFRSFFRSFFFRSFFLYFLLFLFFFFLSFFLFFLSFKFSFLSFFSFFLSFFRSFPISFLIYLSINLLFSSLHISLSLNIYLSIYLSIYLSIYLSISSVNVLLISLYLSIYLSIYLSIYLSICFICSLSVSFYSLIYLYIYLILFIIYLYHSFHSPFHVHYLSQSGHYLSIYLSIYLSIYLSIYLSHSVHLLSIYLSIYLSIYLSGIQSIYLSLLISYSSIYLSIYLSIYLSIYLSIYLICSLSVLFYSLIYLSIYLSIYLSISVCSLSIYLSIYLSIYLSQSVHYLSIYLSISSLFIIIYLSIYLSIYLSISFCSSLSISSIYLIYLSIYLSIYLSFNLSISDPLEQDSHLSFRAVVSCTGRSSLSVPVGSIASHIAKAFRHTHFIDHAEAADWLSGRVLHMRRRTSPIFLSFNCSATPWFFFGHDVEYLAHDNHSPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CD59</accession>
    <name>A0A812CD59_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_37121</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001646">
        <property type="protein sequence ID" value="CAE1271137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CD59"/>
    <dbReference type="OrthoDB" id="10288056at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22823">
        <property type="entry name" value="Gal_Rha_Lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="377"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="469"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="589"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="329"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="519"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="617"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1271137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="643" mass="71036" checksum="6B6428D239F59409" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CIN4</accession>
    <name>A0A812CIN4_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Superoxide dismutase [Cu-Zn]</fullName>
            <ecNumber evidence="7">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SPHA_34357</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Farmed</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="7">Binds 1 copper ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the Cu-Zn superoxide dismutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="7"/>
    <dbReference type="EMBL" id="CAHIKZ030001456">
        <property type="protein sequence ID" value="CAE1264788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CIN4"/>
    <dbReference type="OrthoDB" id="2015551at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00305">
        <property type="entry name" value="Cu-Zn_Superoxide_Dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.200:FF:000001">
        <property type="entry name" value="Superoxide dismutase [Cu-Zn]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="entry name" value="Superoxide dismutase, copper/zinc binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024134">
        <property type="entry name" value="SOD_Cu/Zn_/chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018152">
        <property type="entry name" value="SOD_Cu/Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001424">
        <property type="entry name" value="SOD_Cu_Zn_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10003">
        <property type="entry name" value="SUPEROXIDE DISMUTASE CU-ZN -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00080">
        <property type="entry name" value="Sod_Cu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00068">
        <property type="entry name" value="CUZNDISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="Cu,Zn superoxide dismutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00087">
        <property type="entry name" value="SOD_CU_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00332">
        <property type="entry name" value="SOD_CU_ZN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="6 7" id="KW-0186">Copper</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Superoxide dismutase copper/zinc binding" evidence="8">
        <location>
            <begin position="15"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAE1264788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="153" mass="15997" checksum="7EA624E3D2DA1A37" modified="2021-09-29" version="1">MSIKAVCVMKGDRDVSGVIHFTQESPTKPVKLTGEIRGMADGKHGFHIHEFGDNTNGCTSAGPHFNPDNKEHGAPTDENRHVGDLGNVDSSGGIANVNIEDKIINLTGPHSIIGRTVVVHADIDDLGKGGHELSKTTGNAGSRLACGVIGITK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CLC1</accession>
    <name>A0A812CLC1_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SPHA_38058</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001721">
        <property type="protein sequence ID" value="CAE1273268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CLC1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="54"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAE1273268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="246" mass="29314" checksum="CDE6E581152B8183" modified="2021-09-29" version="1">MSFHIYLSIYLSIYLSIYLSIYIRMFFFISIFVLSYLSIYLSIYLSIYLSILDSSLFIYLSIYLFLSLHYLSIYMSFHIYLSSSFHIYLSIYLSIYLSISLSSYVFHIYFRPFIPIYISIFSYLSIYHFISISVLSYLSIFSYLSSSFHIYLSIYLSIYLSIYLSIYLSIYLFISIFVLSYLSIYLSIFSYLSSFFHIYLSIYLSVSVYLSIFSCLSSSFHIYLSIYLSIFLLSYLLISLRLFISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CLL7</accession>
    <name>A0A812CLL7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_38200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001729">
        <property type="protein sequence ID" value="CAE1273494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CLL7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1273494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="168" mass="19672" checksum="8FF4302327897FE4" modified="2021-09-29" version="1">MKPFHTISSYFLSLSPSFSTSIFLPSLVFFLNLPRFLPPDFPLSTSTFSTSLVFFLPLFLFPLSFYLYFSTLPRFLPTSLFISTFFLPLLFYPPSFSFYLYFSTLPRFLSTSTFLPSLVFFLPLFLFPLSFYLYFSTLPRFLPTSLFISTFFLSIFSILLHCIPYLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CS06</accession>
    <name>A0A812CS06_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_38956</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001791">
        <property type="protein sequence ID" value="CAE1274589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CS06"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039715">
        <property type="entry name" value="ZCCHC10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13491">
        <property type="entry name" value="ZCCHC10 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13491:SF0">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="368"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="399"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="423"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="448"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="475"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="510"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="543"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="625"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1274589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="659" mass="75788" checksum="87F4EA514AF00876" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CUU2</accession>
    <name>A0A812CUU2_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Ubiquitin carboxyl-terminal hydrolase 48</fullName>
            <ecNumber evidence="5">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SPHA_41994</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Farmed</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 17 18">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="5"/>
    <dbReference type="EMBL" id="CAHIKZ030002031">
        <property type="protein sequence ID" value="CAE1279833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CUU2"/>
    <dbReference type="OrthoDB" id="289038at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02668">
        <property type="entry name" value="Peptidase_C19L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000029">
        <property type="entry name" value="ubiquitin carboxyl-terminal hydrolase 48 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033841">
        <property type="entry name" value="Pep_USP48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF722">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="14">
        <location>
            <begin position="89"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00035173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAE1279833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="613" mass="70830" checksum="6CD509D5AACBA35A" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CW20</accession>
    <name>A0A812CW20_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_44704</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002286">
        <property type="protein sequence ID" value="CAE1284368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CW20"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="282"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="367"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="429"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1284368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="468" mass="56307" checksum="83F6E07619A0B877" modified="2021-09-29" version="1">MHCCLHSSYLSIYLSIYLSIYLSIYLSLFIIYLSIYLSIYLSIYLSIYPFLHISIFLSHLLSSMLSFYLPYPFSFFLSILSFFYLLSFLSFFLSFFLSFFLSFICYPFFLSFFLSFFLSFFLNFFICYPFFLSFFLSFVILSFFLSFFLSFFLSFFLLFVILSFFLSFFYLLSFLSFFFSFFLSYLLHFKPYRQTFFLTFLPFFLSFFLSFFLSHLLSFSPSFFYFASNLSFSLSFFLANFLSHLSSILSFFLSFICYPFSFFLSFFLSFSPSFLHSFTPSFFYFASNLSFSTHLPFFLSAISFFLSFIFSFLSFFLSFFFFLSFFSFFLSFFFSFNSYYFIFFYLSIYLSIYLSILSIYPIVSAYLSIYLSIYLSIYLSIYPYLSAYLSQSPYLSIYLSIYLHIYHTLSIFLSIYLRRLTIEFEHESHFPYLSIYLSIYLSIYHTFLIYLSIYPSLDSLCIQASDTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CXR4</accession>
    <name>A0A812CXR4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_46655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002479">
        <property type="protein sequence ID" value="CAE1287551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CXR4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1287551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="300" mass="34354" checksum="3937B2B8BC6EBC55" modified="2021-09-29" version="1">MVGSSVEDLGWLLLRGCARFSRAFRGSAAVTLSFSAGSLNLFYVWRALQFGPFRLPPANGATSPPIRAHARPLDRDCTRHGNLTGETYIILSFSISIFSNLSIYLSIYLSIYLSIYLSIYQILFIAIKSCLSDLSIYLSIYLSIYLSIKFCSYLSNPLSNPVHIYLSIKFCSYLSNPVHLSLSLPLSLSIYLSLYLSIYLSIYLSNPIHIYQILFISIYLSNIDSYSDEQFFLDDPQENPTLNLSSYNLSIYLSIYLSIYLSQFLHIYQSIYLFSFFLSIYLSIYLSIYLSIYLSVPYFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CYS7</accession>
    <name>A0A812CYS7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_42872</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002113">
        <property type="protein sequence ID" value="CAE1281449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CYS7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23304:SF189">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23304">
        <property type="entry name" value="SPOT2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="159"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1281449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="250" mass="29705" checksum="8BCF671A24D4CE1D" modified="2021-09-29" version="1">MTWHGGSEEEEEEEEEEEEEEEEEDDDDEFVHYLSIYLSIYLSIYLSLFIIYLSLFIIYLSIYLSILVCSLTIFVYYLSIYLSFFIIYLSIYLSIYLSIYLSIYLCLFISIYPPLTCVCLDFRKSLLFQPLIYLSIYLSIYLSIYLSICGSYHNTICPLSIYLSIYLSIYLSIYGSSFFLSFFVFSSVITCNLSLLSFFLSFFLSFFLCLFIFFFLSFFLSFFLSLSFHLLLSFFLSFFLSFFLSLSFHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D251</accession>
    <name>A0A812D251_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_47375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002557">
        <property type="protein sequence ID" value="CAE1288899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D251"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1288899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="256" mass="30403" checksum="47840F1A02F86A62" modified="2021-09-29" version="1">MNFPCLSQYAYTHFILTTLIIVLSQSLPLPPYLSIYLYIQIYIIYLSIYLSIYLSIYLSLSFYIYIYIYIYIYIYIKFIYFIFLNVYNSSYLSIYLSIYLSTYLSICHFISIYLNFLSWHRLNISIFSIIYLSIYLSIYLSVMHKLNVSIFSIIYLSLSLSIYLSIYLSIYLSIYLSVSSYLSIYLSIYLSIYLSIYLNFFYNYVSHQSVSTNFLDLPMSVSVCLYPFYINTSLINALSHSLPIYLSIYLSIYLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D3N6</accession>
    <name>A0A812D3N6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_45488</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002346">
        <property type="protein sequence ID" value="CAE1285532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D3N6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1285532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="199" mass="23212" checksum="981D5CAFAF1BE88E" modified="2021-09-29" version="1">MNFLASSYIYLSIYLSIYLSIYLSLFTSIYLSIYLSIYLSHLSWYVSIDLFIPASSYLPILVGLYLSIYLSIYLSIYLSIYLSLFISIYLDLFIFIYLSKPVRIYLPTYLPTYLSIYLSLITSILSLHINLNLFIYLSQNLSQSIYLSLYLSKMFSHSYYFLNSFSLSLSLSLSSLSFTLFSLFLSFILSFYLSFPISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D5F2</accession>
    <name>A0A812D5F2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_47843</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002633">
        <property type="protein sequence ID" value="CAE1289777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D5F2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1289777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="315" mass="36080" checksum="AA861F9153814D41" modified="2021-09-29" version="1">MDDSRIPKRFLYLSIYLSIYLSIYLSIYLSLIHFAQDCTTVQFISIYLSIYLSIYLSIYLSLIHFAQDFHLSIYLSIYLSIYLSIYLSIYLSLREFVQDCTLHIYLSIYLSIYLSIYLSSSKTFRPRLFISVRFTLLSNHGRNACITTPNRRHERNACITTPNRRDGRNACITTPNRRHDRNACITTPNRRHNRNACITTPNSRLDRNACISTPNRRHERNACITTPNRRDDRNACILTPIRRDDRNACMSTPNRRHDRTPASQLPTVDTTRTPASQLPTVDTSGTPASQLPTVDKTGTPASQLPTVDTTGTPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D635</accession>
    <name>A0A812D635_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_46779</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
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            <authorList>
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                <person name="Bekaert M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">Farmed</strain>
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    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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    <name>A0A812D6X7_ACAPH</name>
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        <submittedName>
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        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">SPHA_48553</name>
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        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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            <taxon>Lophotrochozoa</taxon>
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            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
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            <taxon>Sepiina</taxon>
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                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
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</entry>
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    <name>A0A812D6Y7_ACAPH</name>
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        <recommendedName>
            <fullName evidence="6">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
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            <taxon>Sepiina</taxon>
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            <authorList>
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                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAE1290231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="2306" mass="278825" checksum="6F0E9679829EC0D2" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D7U1</accession>
    <name>A0A812D7U1_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Iron-sulfur cluster assembly 2 homolog, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">HESB-like domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SPHA_46769</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Farmed</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway. May be involved in the binding of an intermediate of Fe/S cluster assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterotetramer; forms a dimer of dimers with IBA57. Interacts with [2Fe-2S]-ISCA2 forming the heterodimer [2Fe- 2S]-ISCA2-IBA57 complex; [2Fe-2S] cluster binding is absolutely required to promote the complex formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HesB/IscA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002491">
        <property type="protein sequence ID" value="CAE1287783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D7U1"/>
    <dbReference type="OrthoDB" id="1938621at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120510">
        <property type="term" value="C:mitochondrial [4Fe-4S] assembly complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.300.12:FF:000006">
        <property type="entry name" value="Iron-sulfur cluster assembly 2 mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.300.12">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016092">
        <property type="entry name" value="ATAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000361">
        <property type="entry name" value="ATAP_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00049">
        <property type="entry name" value="iron-sulfur cluster assembly accessory protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43011">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY 2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43011:SF1">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY 2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01521">
        <property type="entry name" value="Fe-S_biosyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core" evidence="10">
        <location>
            <begin position="52"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00057540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00073313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00077082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00093471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAE1287783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="156" mass="17244" checksum="D76E7443F6AEBBEC" modified="2021-09-29" version="1">MIMAVLRSTVRQAVKPFTSLPINLRAFHSEFIKCSSTTSNLDSTNKTEDSLIISDRCVLKMKKMGSPHCFLRVSVEGGGCSGFQTKFDLDTAVKEDDRLFERDGVKVVIDVDSLEFLKGSTIDYEEELIRSSFAITKNPQADQGCSCGASFSLKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D8A2</accession>
    <name>A0A812D8A2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_48333</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002678">
        <property type="protein sequence ID" value="CAE1290677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D8A2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1290677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="219" mass="26426" checksum="2E3AD6E4FAB89C50" modified="2021-09-29" version="1">MNIVQTYSWQSGNIIYLSIYLSIYLFLSRVNRYLSIYLFLSRPNRYLSIYLFLSRPNRYLSIYSYFGLIVIYLSIYSYLGLIVIYLSIYLSIYLSIYLFLSRPNRYLSIYLSIYSYLGLIVIYLSIYLFLSRPNRYLSIYLSIYLSIYSYLGLIVIYLSIYLSIYLFLSRPNRYLSIYLSIYLFLSRPNRYLSIYLSIHNEIKMLTSHTTSNKRFKKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D8M2</accession>
    <name>A0A812D8M2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_51800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003164">
        <property type="protein sequence ID" value="CAE1297044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D8M2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1297044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="295" mass="35558" checksum="D9034DF6EF9FC206" modified="2021-09-29" version="1">MNTVIRLALRKEQFRQLAYCCHVEGLILSFHFLSFSFVVDFFFLFFVLSSFFFCFVSTYLLSTFIVMLINKNTFLSFYISVFVLPACLFDSFFLYRTIFFLFFKSFVCLFVCMLLSFVHFLSFFQFLCFFLCSFLSISFFLSFSFQFLSVSFLQFLCLFICLLRNSFSLFFNNFIHSLSFISRFLSVCLTVFLSIFILSRSFFLSFFLSFFLSFFYLCTFLYHLLDLLKFLSIPFSLHPFVSFAFRSSHSFIRSFIHSFVRLFIHIFFRKLNLFSFFFKKKNPSYSFVYSYLSHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D998</accession>
    <name>A0A812D998_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_48478</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002700">
        <property type="protein sequence ID" value="CAE1290879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D998"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1290879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="294" mass="34617" checksum="55C0921714461B97" modified="2021-09-29" version="1">MSLASSICTYLHQTNCPAFHSLIGLNPLILHLLYISSHPDHYHTLPLDHTLSISHILLLVLLPGGSFFLFQVSFDPLFLFFLLVLLTHPFLLNFYIAFFTAFFVHLLSLSFSLPLTVCSYLSIYITHFLYLSYYLFPLLFYFLLCLFFLLPHPLQISLSASSIHYFSYYFSLYFPCFIFLLLLLYFSSSTCYTLYISFIFLYFSHSLIFFLLFLLYFLIFYSSSAFAISLSFESCFLPFLSSYLFFFSSCFPPPFTHNMDRKYLSIYLSIYLSIYLIRTLMEKKICISTFENTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DAB8</accession>
    <name>A0A812DAB8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_51570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003131">
        <property type="protein sequence ID" value="CAE1296662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DAB8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1296662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="186" mass="22209" checksum="7F34FA314FF40F8C" modified="2021-09-29" version="1">MRRRPWRKGTFIYRGVGVCSRHSFDASGSLTELVCCKSVSIYLSIYLSIYAYSLSILSIYLSIYIYIYIYIYIYLSLFIIYLSLFRSLYQFIISIYLSIYLSIYLSIYLSIYLCLFIIYIYLSIYIYIYIYIYIYIYILFIIYLSIYLSIYLSIYLVHYLTAYGYQALKTAQSIVHGYANIGKLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DCS5</accession>
    <name>A0A812DCS5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_52934</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003327">
        <property type="protein sequence ID" value="CAE1298997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DCS5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="409"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="437"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="466"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="498"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1298997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="519" mass="62009" checksum="262016BD3270A632" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DF79</accession>
    <name>A0A812DF79_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_52591</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003292">
        <property type="protein sequence ID" value="CAE1298452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DF79"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1298452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="156" mass="18828" checksum="88A7E8238EA93EA7" modified="2021-09-29" version="1">MTFLSFFLSFFLSFFLSFFLSFFLSFFLKFSLYITFPFLSFFLSFFLSFFLSFFQEGLAFNGRRRQADWKESRPDITEDVSRFSSNATTVGSHCFVPLSGKKLIVQSFFFFSFLHFFHVFAWPILFYLFICCFHSFFFTLISDMFLFFFLILFCHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DHI1</accession>
    <name>A0A812DHI1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_53155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003358">
        <property type="protein sequence ID" value="CAE1299253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DHI1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1299253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="243" mass="28375" checksum="DA97A47586F7CD23" modified="2021-09-29" version="1">MECGFLRIFFVELHINIYLSIYLSIYLSIYLSIYLSVTFFLSIYISISVTSYLSIYLSIYLSISVTSLSIYLSIYLSIYLSVTFYLSIYLSIYLSNYLSIYLSIYLSACVPTYLSVTSYLPICINHFLSIYLSIYLSIYLSIYLYQSLTIYLSIYLSISLSIFLAICDFLSCYLSIYLSIYLSIYLSIYLILFSSSLDSISQFFILFSSSNSFQSVCFFFYSLLLFFTAFHFHQFILQFFSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DHM3</accession>
    <name>A0A812DHM3_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SPHA_54323</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003526">
        <property type="protein sequence ID" value="CAE1301286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DHM3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="222"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="259"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="321"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="345"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="376"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="402"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="169"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAE1301286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="428" mass="53017" checksum="BFB8E81DB5E446D3" modified="2021-09-29" version="1">MLSSNLDERERLKRRQPKTRALLNLLLFLFLSFSLSAHSCFGKIWIMIMIKFYLLIFHHVFLVFLFLFSFLASCFFFFFFFTFFFFTFFFFSFRIRFSTSLIYLLFFYISLSYHKILSFFSFFLSLIFFLSVFLLSVVLSFFLSFFNFLFFRFFLFLLVLISLTYFLSSNEPIYFVLLIVLILCFFYVFFFFTLSFYFFVFSLFYVLSFFNLLFFLQQTLNYYFHFYLFFMVFFLTFFLLIHSFYYFYLFLISILRFNLFSFVFFFFPLVYVLFFSSSFLTYVLFFLFWLSSFFHFFLSCLVLSFFFFLFFLSFVMSFSAFLYHCLFHFFSLLSCPVFLSFFLSFFFLFVMSFSVFFFIIVFFTSFLLSCPFFLSFFFLSFFLFFLFVMSFSAFLYHCLFHFFLSFLSFFLSFFLSFFLSYQTFLSHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DIQ3</accession>
    <name>A0A812DIQ3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_53056</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003348">
        <property type="protein sequence ID" value="CAE1299175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DIQ3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032670801" evidence="2">
        <location>
            <begin position="18"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1299175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="204" mass="23992" checksum="C7957157B8B2F62C" modified="2021-09-29" version="1">MFLPFFIFFFIFDQASNGTIQRKLSCSSVWPYWLSGHLPFFSFNHFPDLTINVRFSYNFPSFTSIYLSIYLSIYLSIYLSIYLSICGSGYVNLHLSHLPIVCSFLSIYLSIYLSIYLSIYLSSYENINLSIYLSMILFFSIFLSSRFSFYLSIYLSIYLSIYLSIRYLSIYLSIYLSIYGSGYEICIYLSIYLSIYLSIHHLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DJ74</accession>
    <name>A0A812DJ74_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_52730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003317">
        <property type="protein sequence ID" value="CAE1298714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DJ74"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1298714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="240" mass="26305" checksum="74BB5162AC990B5A" modified="2021-09-29" version="1">MRRAAATYRIDKLIGRPRRRSITRIRSALSGSSYVSASPEKPNSSASTCVRRAAARCIDNAGTYPVEPRCNVRKHVLIWANVDLVDRVAPARARPVSSRLSMHSKMVFALVCAKGVGLQLLSVSHTDTDPDAVIPDAPLASPVSAIRSSSNYREHAQSSSFPSLSFNGLARLRDARGPFSDWFQCYHSGQHYGPHCPVPNTHAPSCEFPHQTTFQSVAEQGRTSPQTLIRVLLKRMPTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DJE2</accession>
    <name>A0A812DJE2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_57808</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003916">
        <property type="protein sequence ID" value="CAE1305371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DJE2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1305371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="320" mass="37536" checksum="A7CE1B7CBDAACBC4" modified="2021-09-29" version="1">MFSISFHSLFQSHLRELFSYLSIYLSIYLSIYLSIYLVPHFIKTLSLFFFFPFIFLPPLSLSQFLSHLICISLNLSLFLSLSLLLSLSLLLSLSLLLPLSLLLSLSPSFSLYLSYLSYLFSFSLCRYSHLLFRSFFITPLSRSYFLSLSLFLSLSLFLSGYYLFSRLISLFSKTSLSLSPPLSLFLSLYIYLYLPSRSFIHILLYLVSVFYITICLSLSLSLSLSHCTHLTFRSFYPPFLFLSFFLFFFLSILLFLCTSSFSFIYSLLFFPSFLFLSIYLSIYLSIYLSIYLSIYLYLSLSLYIYIYMNYDIYLFSYLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DK57</accession>
    <name>A0A812DK57_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_55189</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003651">
        <property type="protein sequence ID" value="CAE1302697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DK57"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1302697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="235" mass="26939" checksum="7AFAD4AE36AF4DFD" modified="2021-09-29" version="1">MTGNNFCVILITIFILIIFLVIIIFILIAIFIVITIIIVITIFLVITVFILIAIFIVITIIIVITIFLVITVFILIAIFIVITIIIVITIFHVITVFILIAIFIVITIIIVITIFILITIFILITIFILIANFIVIAIFLVITIVILISIFLVITIFIAIAIFIVITIFIFIIIFILITGIFILIAIFILIAMFIVITIFIVLLSLFLFSKEKVIDSDMFLYWLKQLFSIYWNKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DL30</accession>
    <name>A0A812DL30_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SPHA_58720</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004034">
        <property type="protein sequence ID" value="CAE1306458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DL30"/>
    <dbReference type="OrthoDB" id="6088609at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050569">
        <property type="entry name" value="TAAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249:SF372">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249">
        <property type="entry name" value="HISTAMINE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="270"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="354"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="98"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAE1306458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="416" mass="47020" checksum="5077839EA145638E" modified="2021-09-29" version="1">MLVAKLFSIRKVVTRANHPFSPLPTSFHLSPLPTYTSVAASELEASVLSTINKMTDFEFEYPSYGLRNRYGSDKLGRPDQEFNYYLLHIGVSILVTVPNLFLFITLMSKSGTGNMRPLDKILLNYTINGILWGVFGHSLFTHTYFFNWSFGIIACRIYHTLMVAFDFAFQFHMFVVSVDRVLQAISPYRYLQRVNSVGCGILLAFPWVSTILVTLPIYFVGFASNSTTPSLALLPVTTITNGYPDAVTEISLPAPNPVCSSALIPPANRAFHLFTFIICLFTVASTFIVIYFLLKSRGLQSYRLLTSVDRRSIRSSLTAGIVVNLMFAATMFVLKCFHQHIMDNGYRQHDERFWIALDVFAYLAVSSAGIIPVLWFVDSDVRKALYTLYRRIVPEPSEESKLASKSKRDSFELIND</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DM35</accession>
    <name>A0A812DM35_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_54767</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003595">
        <property type="protein sequence ID" value="CAE1302052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DM35"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="322"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="363"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="389"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1302052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="563" mass="62048" checksum="50E478A2C9DA5037" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DNH8</accession>
    <name>A0A812DNH8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_55060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003633">
        <property type="protein sequence ID" value="CAE1302456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DNH8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1302456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="259" mass="26775" checksum="4BD21DA594CC4872" modified="2021-09-29" version="1">MHLKDSSALSHILLSLSLSLSLSLSLSSTLSLCLPLPRSYCLSLSLCLCLSVSVSLIVYLSACLSLSSLSFCFSVCLSVSLSVFLSLSVSVCLPSVFRSVLTNASLSLSLSLSLSLSLCPCLSASVSLSSSLCCSLCLPIFLSLFVSLCWSISVSVSASLAFSLSHSLSLSLCPYLPVSLPVSLSFCLSECPSLSLSLSLSVGLSLFLSLPRCFPLSLSASLSASLSLSLSLSLLSACLSLSLSLSFSVSLSVCLPVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DT16</accession>
    <name>A0A812DT16_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_60199</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004174">
        <property type="protein sequence ID" value="CAE1308304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DT16"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1308304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="253" mass="29293" checksum="916EE529BB020EBD" modified="2021-09-29" version="1">MRRAGEQPDIPQSFGLLLSIYLSIYLSIYLSIYLSIIVSSCFVILVLVYLSIYLSIYLSIYHSIFLFRYLSYRFLFIYLSIYLSIYLSIYLSIIVCSCFSILVCSSFAILVCYCSFIYLSWFMSIYLSIYLSILAGSRLSILVGSWLSILVGPYLSIYLSIYLSIYLSIYLSRFSFIYLSRFLVIDLSRSLSIYLSIYLSKIFSPSLYTFKNKTIAPGANTADYTVLFYFRLQTSRNIYEYASSNSADVFCRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DT72</accession>
    <name>A0A812DT72_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_62140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004414">
        <property type="protein sequence ID" value="CAE1310589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DT72"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1310589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="303" mass="35806" checksum="E7847B3B824C2069" modified="2021-09-29" version="1">MTSDIVGRTHGYWQLSACKLISSCSMNLLMFALSLAEIRNEDIAVYCKVHATYYSPTRPFSFSCLSFSFLSLFLLSLFFLSFFLSFFLSFFLNLCLFRIPSRFPPFFVLNSYLFFILFPFPIHFVSSSSSLFFSLFLSCIISFFLFFVSRFFLFSFLLYIFLPPFIHLFLNFSFLPSFLPSFLPSYFSSTFLPYIPSFLLSLIRSFLSFAYLLFPISLPPFFLSFIHPSLLSSFPHFLPIIFFYSFRNFHYNFLFRSISLSMVFIFIYPLAYPVSFFLSFFLSFFLSFFLSFFLVLLFVFLLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DVS1</accession>
    <name>A0A812DVS1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_59445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004115">
        <property type="protein sequence ID" value="CAE1307392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DVS1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1307392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="227" mass="26144" checksum="47EA6AD9F5EA58FB" modified="2021-09-29" version="1">MLSFLTFLLPPCYLFIALFLILLLFFLPPFLHSSMLSFLFLFLLLTLFIALFLPSFSFLHSLMLSFLPSFLPSFYLPSYTLHCSLSYFLFSPFLHSLLLSFLPSSLPSFYLPSYTHQCSLSYLPFTFLVTLFIALFLILLLSLFLPPFLHSSMLSFLPSFSLPCYTFHCSLSYLPIPSLLTLFIALFLTLLLTLFLPPFLHSSMLSFLPSFYLPCYTLYCSLSYPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DXG0</accession>
    <name>A0A812DXG0_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">LicD/FKTN/FKRP nucleotidyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_61684</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004384">
        <property type="protein sequence ID" value="CAE1310055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DXG0"/>
    <dbReference type="OrthoDB" id="444255at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009100">
        <property type="term" value="P:glycoprotein metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007074">
        <property type="entry name" value="LicD/FKTN/FKRP_NTP_transf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052942">
        <property type="entry name" value="LPS_cholinephosphotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43404">
        <property type="entry name" value="LIPOPOLYSACCHARIDE CHOLINEPHOSPHOTRANSFERASE LICD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43404:SF1">
        <property type="entry name" value="MNN4P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04991">
        <property type="entry name" value="LicD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LicD/FKTN/FKRP nucleotidyltransferase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1310055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="201" mass="24107" checksum="E20404ABCEE12B61" modified="2021-09-29" version="1">MNNINFFLYDGSLIGSYRHHGFIPWDDDVDVFVNSSQKHLLAKEGAKLPGFQVFTPKNFQWKFFHRNLSTSIGDKEFRWPYIDIFFWEVSSTHLYDYTRLQRGMSYEKAIVFPLQFRPFEGALLKAPINTEAFLKKKYDIAECQTNTYSHRYEQPNRWSRQVPCEKLEKFYPFVKHERKTRCEEHLIDKGHVIRTFTLNDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DZY4</accession>
    <name>A0A812DZY4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_65253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004704">
        <property type="protein sequence ID" value="CAE1314281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DZY4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1314281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="162" mass="19969" checksum="0E5065F2F4F627E4" modified="2021-09-29" version="1">MTINPSDIDDTQTHNHRPVFISLYVSIVGGFRFFRFFFLSFSFIFFLLLFLVFSFSFFFHFVFFLSFFFLSFFFFSFSIFLFCFPVFPSYLFSFPYGFHFFFLPFIFFSFVSLYLLLSWLHFCFFFSSFFLSFFLSFFFFLSFFLSFFLSFFLSFLPFLLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E091</accession>
    <name>A0A812E091_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PXDN</fullName>
            <ecNumber evidence="5">1.11.1.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SPHA_63515</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.7" evidence="5"/>
    <dbReference type="EMBL" id="CAHIKZ030004549">
        <property type="protein sequence ID" value="CAE1312248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E091"/>
    <dbReference type="OrthoDB" id="6160029at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140825">
        <property type="term" value="F:lactoperoxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475:SF4">
        <property type="entry name" value="CHORION PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475">
        <property type="entry name" value="OXIDASE/PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00457">
        <property type="entry name" value="ANPEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <feature type="binding site" description="axial binding residue" evidence="4">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR619791-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAE1312248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="150" mass="16909" checksum="8221F544FCE2CB77" modified="2021-09-29" version="1">MTMALHNLFFREHNRIADALSAAHPNWTDEILFQEARRIVVAEIQHITYGEYLPKVLGDDYMELYSLKPLQNGTAQYSRNVNPNTRNGFAAAGVFHSHSGIRSTVTIGNIEYPLSSIFFNPDVFYEGSEAPTAIFQGLLNDLSQMIDRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E0J0</accession>
    <name>A0A812E0J0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_64944</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004679">
        <property type="protein sequence ID" value="CAE1313913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E0J0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="19"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="293"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="381"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="405"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="447"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1313913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="480" mass="57572" checksum="2D88C43EE5AA6C66" modified="2021-09-29" version="1">MLQCPTSVSTFLCLYIDPFLFFILPLLLMLLLLLLLLLLLVSFSFNLLVFLLFFSDVLFHLLFSIFFYTSSNSIHLSLFFFSLIYTLFFFFPIFSLFFSFSLFVLLSLSLFFLFLLFDYCSFSFSFFSLFFSFALIYLPFFIPSFFPFLLFLLFHLHFAFLFPFPSFFSFLSFSINPRLSFILLLLFSFFFSFIYPIFFSRSFLFFLTLPSSRSHISFFLSFFFLSHLCFLFHLFLLFHLPIIYFSISVFFFPFFHLHFVLLEFIFLSFFCFFLLFDLLFIFLSLIFPFFNSFIYISFFCFFFFFFSLFFDLLLFFPLFLLFLFFLRFGLLIVLSPSLFFFFISLIHLSSFLSFSISFFFSSSWFSYTFLFFFLSSSSIPPLLLLLSFFLLIFFLPSFLSSFLSFFFLSFFLSFSFSSSASSLLILFSKNLIQSIFFRHLKSCSNQFLPLSIYVCSYLSIYLSIYLSIYLSIYLSNQLCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E3Z2</accession>
    <name>A0A812E3Z2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_66195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004770">
        <property type="protein sequence ID" value="CAE1315213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E3Z2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1315213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="172" mass="20414" checksum="D8C8A57B079375C3" modified="2021-09-29" version="1">MWKAVSCLNTYRCGEQNPARIRTDVESSILLKYVQMRRAFAFFLVLFFIFDYSLSTSFLFRSSFFFITFFFISLRPSISSVNPYFFLLFLLLLFLLFSPHTSPLASPPTPCSLSYFYYLLIPRLFSFSPFSFSFFIDIFIFFLSFFLSFFLSFFLSFFLSFLSILLFPCSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E4N1</accession>
    <name>A0A812E4N1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CSMD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SPHA_65445</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004724">
        <property type="protein sequence ID" value="CAE1314595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E4N1"/>
    <dbReference type="OrthoDB" id="6162941at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051277">
        <property type="entry name" value="SEZ6_CSMD_C4BPB_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45656">
        <property type="entry name" value="PROTEIN CBR-CLEC-78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45656:SF4">
        <property type="entry name" value="PROTEIN CBR-CLEC-78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0768">Sushi</keyword>
    <feature type="domain" description="Sushi" evidence="5">
        <location>
            <begin position="10"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="5">
        <location>
            <begin position="68"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="5">
        <location>
            <begin position="192"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="5">
        <location>
            <begin position="301"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="5">
        <location>
            <begin position="359"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="5">
        <location>
            <begin position="520"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="97"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="217"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="329"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="388"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAE1314595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="631" mass="70224" checksum="D45E10CDF46B3373" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E4U4</accession>
    <name>A0A812E4U4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_67143</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004855">
        <property type="protein sequence ID" value="CAE1316427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E4U4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1316427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="347" mass="40946" checksum="58DDBB31F54CE80A" modified="2021-09-29" version="1">MFPELSLKNLSIYLSIYLSIYLSIYISIYLSQSLHFISYLSIYLYPLHLSIYLSIYLSVVHLSLFIVYISLPVITLHISHLSIYLSITVVTFHFLSIYLSIYLSIYLSIYLSIYLSQPLHLISYPSIYLSITVVTFHFLSIYLSIYLSIYLSIYLSMFIVYLSLPPLHLITHLSIYLSQSLHFISYSSIYLSIYLSIYLSIYRSIYLSIPAITFNLHLSIYLSIYLSIYLSIYLSISPSHYITHFIYLSSYLSIYLSIYSIYPSIYIYLSIYHSRYIPFPIYLSIYLSIYLSIYLSIYLSQPLHLISHLSIYLSIYHSRYISFPIYLSIYLSIYLSIYLSIYSSHYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E6G3</accession>
    <name>A0A812E6G3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_67183</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004867">
        <property type="protein sequence ID" value="CAE1316506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E6G3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="286"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="315"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="352"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="412"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="444"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1316506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="463" mass="57102" checksum="08AE6AABBFE85AFD" modified="2021-09-29" version="1">MQFCIKKSGFVFLFLHSSIYLSIYLSIYLSIYIYIYMSNSVCLNRTLIVSIYLSIYLSIFYLFLFISNCSSHFSGFILFIHNPRSFSLFDYFIFFIIPIVVLSFDFVLIFACFFFHFFHAFFLSLSSFFHPFFLFLDLVKFVLFFFYFFLHLFLFLLLFFFFFFLSFFSSFFLLFSFLLSNLSRPIFFYIYFLLFSFMYSFSFYFAPLFLLKVYLSFGFFVIRLSYFIFCLSNSPIFLFPTFFLSFVVSFVLSFFPFYFLWIYFHYSFSIFPFIFLSLHSSNHFSVTIFLSFFLSFFLSFFFPFLFYLVFFFPVLFISIFSCIHLFSIFSFFLSFFLSFFLSLDLVIYFPIFIYRFFHLYFFLFLFDHFFHVFIINLHSFYLFYFIFLWIYLLLTYYLFFRSFINSFFATCLSFLVSFYSFFLSLDLLIFFLFFFLFFLSCINYYSTFSFLSFFFFYSIFLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E7A2</accession>
    <name>A0A812E7A2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FBXL17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SPHA_68001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004932">
        <property type="protein sequence ID" value="CAE1317402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E7A2"/>
    <dbReference type="OrthoDB" id="550575at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057207">
        <property type="entry name" value="FBXL15_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318:SF190">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25372">
        <property type="entry name" value="DUF7885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="3">
        <location>
            <begin position="185"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="146"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="146"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAE1317402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="557" mass="62802" checksum="F087EABDA53880A8" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E7Q7</accession>
    <name>A0A812E7Q7_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD(P)H-hydrate epimerase</fullName>
            <ecNumber evidence="3">5.1.99.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SPHA_68044</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Farmed</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6R)-NADHX = (6S)-NADHX</text>
            <dbReference type="Rhea" id="RHEA:32215"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:64075"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(6R)-NADPHX = (6S)-NADPHX</text>
            <dbReference type="Rhea" id="RHEA:32227"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:64077"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.99.6" evidence="3"/>
    <dbReference type="EMBL" id="CAHIKZ030004932">
        <property type="protein sequence ID" value="CAE1317408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E7Q7"/>
    <dbReference type="OrthoDB" id="10064708at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052856">
        <property type="term" value="F:NAD(P)HX epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10260">
        <property type="entry name" value="YjeF N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004443">
        <property type="entry name" value="YjeF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036652">
        <property type="entry name" value="YjeF_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032976">
        <property type="entry name" value="YJEFN_prot_NAXE-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00197">
        <property type="entry name" value="yjeF_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13232">
        <property type="entry name" value="NAD(P)H-HYDRATE EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13232:SF10">
        <property type="entry name" value="NAD(P)H-HYDRATE EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03853">
        <property type="entry name" value="YjeF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64153">
        <property type="entry name" value="YjeF N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51385">
        <property type="entry name" value="YJEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032688584" description="NAD(P)H-hydrate epimerase" evidence="10">
        <location>
            <begin position="19"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="YjeF N-terminal" evidence="11">
        <location>
            <begin position="32"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAE1317408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="296" mass="33841" checksum="65B0E84D2FFBA08D" modified="2021-09-29" version="1">MIHLSSVAFLILLGLCRGHLLKENTILNQEESQKIEEELLTEYAFSLEQILELEGYSCAVAIAQVYPLDKMSKDNGAILVCCGPGNNGAHGLVCARHLKHFGYKPSIFYPKTSNKQIFENLRLQCERMDMPFLSFFPSEAHLIDSAYNLVIDAIYGIQHAGPVKGDFGVLLETLKKVENPICSIDIPSGWDNENDNPDALQPAMLISLKAPKLCARHFHGTHHYLGGRYIPRTLELRNNRQAQLIRFQPIHRNAQKFCFHFWFFRWTHRELPAFSMEQSLCRVSLFLSHIQTKCLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EAK4</accession>
    <name>A0A812EAK4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_69166</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005066">
        <property type="protein sequence ID" value="CAE1318710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EAK4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="312"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="366"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="409"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="446"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="476"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="507"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1318710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="542" mass="63608" checksum="3917EE911DA77D8F" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EH52</accession>
    <name>A0A812EH52_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_70807</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005183">
        <property type="protein sequence ID" value="CAE1320565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EH52"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="350"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="393"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="439"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="471"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="527"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="615"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1320565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="641" mass="73244" checksum="621AEBD92F2EC410" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EHG3</accession>
    <name>A0A812EHG3_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Armadillo repeat-containing protein 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_75467</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005459">
        <property type="protein sequence ID" value="CAE1325861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EHG3"/>
    <dbReference type="OrthoDB" id="6145023at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1325861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="238" mass="26597" checksum="501D90F874B56274" modified="2021-09-29" version="1">MPVSTTVSIILNTTDSDAAISFNYMENGVVEFMKKNCCWDHYLSVNNERVTEILLYSVAIIQNISRFFSVKSRCGDSVNWLIPLLSVTKGNIHIHSVMLLANMVDANNNAVLINAQGCINDIIHISNAAVPDMEHKGYHLWELLLAIGKLAKNDSIRKKLKKCGMLDLLMTLIQKNDDNIQALALNIMLTMILDDDILSFCHSSSVTKDLRPILESIKDTDDFMLSNNAKSALQIINN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EIV4</accession>
    <name>A0A812EIV4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_73352</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005375">
        <property type="protein sequence ID" value="CAE1323474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EIV4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="342"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="367"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1323474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="398" mass="46382" checksum="02C78151FEAD450C" modified="2021-09-29" version="1">MYFYFHGKYFHAMYLSANHSYFFHIRLCNLSIYLSIYLSIYTSMSINNDLYIYLSIYLSHFSLFLFISISLFLLIYSYLSIYLSQYISRFLSIYLSIYLSILRSHRATARTGSQPASAATTSRATGTTVRGCQLARRPAVSPARQADRFDFDFLQRSLEIRQTIIDGFVCIILFGISIPSFLPSYLSIYLSIYLSIYLSIYLSIYVCPFSIYLSIYLLGRTHLLTRNGLFVWHIYSFLPPFISIYLSIYLSIYLSIYLSMSVHFPSIYLSILFSSTTVFVLIHTPTREKLTTSQHYLSIRSFIPIYLSIYLSIYLSIYLSIYLCVNSRTILFDLLADTKQSIYLSIYLSIYLSIYLSIIVCPFSFYLSIYLSIYLSIYLSIYLSHTMHCALFDPLPKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EKV5</accession>
    <name>A0A812EKV5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_72714</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005341">
        <property type="protein sequence ID" value="CAE1322794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EKV5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1322794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="248" mass="28523" checksum="526EAE0AF1A6DEDD" modified="2021-09-29" version="1">MCIFTTNIIYLSIYLSIYLSIYIYILFISIYLSIYLSIYLSIYLSIYLSVFISNCLSIDIYLSVSISIYLSIYLYIYICVCVCVCVCLCVCVFISLSIYLSIYLSIYLSNYLSNYLSVFISNCLSIYIYLSAFIAVYLSLYLTVYSYLSIYLSQFAHIYLSICLSVYLSQSVYLSLYLIVYSYLSIYLSIYLSIYLSIYLSICLSPPVVTISLFCVSSPFCFPSSSSPLSISSSLFSSFSFPYFFLVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EPG2</accession>
    <name>A0A812EPG2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_77441</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005518">
        <property type="protein sequence ID" value="CAE1328019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EPG2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1328019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="180" mass="21361" checksum="20AB232B57A27A1C" modified="2021-09-29" version="1">MREENEVYKQIYVHLKTTIILSIYLSIYLSIYLSQSITIYQLVCSYLSIYLSISVYYYLSISLFISIYLSIYLSIYLSIYLSIYLTQSITIYLSVSLFISIYLSIYLPIYLSQSIPIYLSIYLSEPDNNTIYLSIYLSVYLSTYLYLSIYLSIFFYLSIYLSIYLSIYLSIYLSIYLFPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EQ05</accession>
    <name>A0A812EQ05_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_80127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005591">
        <property type="protein sequence ID" value="CAE1330885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EQ05"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="314"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="343"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="371"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="405"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="431"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="458"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="492"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="525"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1330885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="544" mass="66747" checksum="78111DB310F63024" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EQI9</accession>
    <name>A0A812EQI9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_77592</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005519">
        <property type="protein sequence ID" value="CAE1328078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EQI9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1328078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="297" mass="35072" checksum="8717662A06918DAD" modified="2021-09-29" version="1">MSLCHPSQSQTVFLLSDTLYINGYLQLPVLCRSKQRMPVYHSSQSLAFFFFQEPSDITVHHGFLYFIDLSNVCPFTTPLSPWCFSSFRSLLTSRSKQDMSLYHPSRALGFFFFQALCPLTVLHSFLLSFYFLLSFFCPAPIIIYSFLLVFSFFLSFFLSFFLSFFLSLYFSLCYLFRSSLFMTSFRHISPPFSFSPSFFFFFVYFFLSFFLSFFLSFSLSFIIIYCFFLLFYFLLSKEQRDLLFFSFSLSLSLFAGRKTALLDDAYTDELQISHSPRNDVQRSKECIERHVTDRLTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ES25</accession>
    <name>A0A812ES25_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ciliogenesis and planar polarity effector 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">REM2- and Rab-like small GTPase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SPHA_77726</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005521">
        <property type="protein sequence ID" value="CAE1328128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ES25"/>
    <dbReference type="OrthoDB" id="10266641at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030030">
        <property type="term" value="P:cell projection organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039677">
        <property type="entry name" value="RSG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14983">
        <property type="entry name" value="CILIOGENESIS AND PLANAR POLARITY EFFECTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14983:SF1">
        <property type="entry name" value="CILIOGENESIS AND PLANAR POLARITY EFFECTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0969">Cilium</keyword>
    <keyword evidence="7" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAE1328128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="166" mass="18977" checksum="9567458473770388" modified="2021-09-29" version="1">MEIMSSLQRGDMSHKTFGLLEHPHLPPMVTTEEVQYKIMLVGKNGVGKTATAANLTGYSPMENYYETPGIQVWQTYWPARIRQLNKVMLFHLCLWESGTTAMRKFDHILPALKENVDCILLVFSLLDKSSFDELPHLISRLTEPNDNVCKIAIGTKYPFIIIYKAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ESB3</accession>
    <name>A0A812ESB3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_76533</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005493">
        <property type="protein sequence ID" value="CAE1327038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ESB3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
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        <source>
            <dbReference type="EMBL" id="CAE1327038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="151" mass="18494" checksum="20454E00EE36016B" modified="2021-09-29" version="1">MFFFFPSKCILLLSSFFLSSFLSFFLSFFLSISRHSFSLSFFQYVFFLSYFLCFFVSFFLSFNIATFFLSFFQYLVFLSYFLCFFLSFFQYRDILSLFLSFFFGMLSGAFSSKYLFFFVFFKIVLSFFLFFFGIFLSFFIYIKIFIFLLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EWQ1</accession>
    <name>A0A812EWQ1_ACAPH</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">SPHA_80803</name>
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        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
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    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000597762">
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    </dbReference>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
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        </submittedName>
    </protein>
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    <organism evidence="4 5">
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            <taxon>Coleoidea</taxon>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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            <begin position="428"/>
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    </feature>
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        <source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
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        <source>
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    <sequence length="636" mass="71149" checksum="1586A0897F92457C" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ANU6</accession>
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        <submittedName>
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    </protein>
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        <name evidence="4" type="ORF">SPHA_2556</name>
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            <authorList>
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                <person name="Bekaert M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="4">Farmed</strain>
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        <text evidence="1">Belongs to the cytochrome b5 family. MAPR subfamily.</text>
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    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
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    </dbReference>
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        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050577">
        <property type="entry name" value="MAPR/NEUFC/NENF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281:SF4">
        <property type="entry name" value="NEUFERRICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="100"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="3">
        <location>
            <begin position="122"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAE1148866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="313" mass="36767" checksum="EB087374F98A88B5" modified="2021-09-29" version="1">MLDSFLSCFLFLFFFLFSLFFFFFSFFLSFFLFPSLFSFFLSFFLSFFLSFLFSPFSLFSFSFFLSFFLSFFLSFFLSFFHPPSFFLSFFFPPSFLSFFFFLSFFLSFFLSFFFLFSFFLSFFLSFLKKNTIFGQVYDVSKGRRHYGPGGAYSFFSGIDGSRAFVTGDFTEEGLTDDIESLMSSQLADLSNWMLYYNENYKLLGYLAGQFYDSNGQPTKVLKKIKYEIKEFRNKQKILKAAENLLPPCNTEWKPSGSRVWCSKNSLYLLILSLISSNITRVIHYLMPLLVSHSLPGSSHSFLELNTPALHYSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812APU2</accession>
    <name>A0A812APU2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_4472</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000141">
        <property type="protein sequence ID" value="CAE1155356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812APU2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="285"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="369"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="399"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="431"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="495"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="522"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="549"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="579"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="608"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="641"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="666"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="699"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="726"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="753"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="781"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="812"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="837"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="863"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="890"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="917"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="944"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="975"/>
            <end position="1003"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1155356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1004" mass="125394" checksum="414A516ACD546371" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ARZ3</accession>
    <name>A0A812ARZ3_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7042 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_3960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000121">
        <property type="protein sequence ID" value="CAE1153643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ARZ3"/>
    <dbReference type="OrthoDB" id="9979716at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055470">
        <property type="entry name" value="DUF7042"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22255">
        <property type="entry name" value="LP06548P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22255:SF9">
        <property type="entry name" value="LP06548P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23069">
        <property type="entry name" value="DUF7042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7042" evidence="2">
        <location>
            <begin position="34"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1153643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="265" mass="31171" checksum="59AD8755C914352C" modified="2021-09-29" version="1">MFESLSLSHTHTHTIYLSIYLSIYLSIYLSIYLTMHECADNSRYKFRFKQCPGIPRTSDLEFDFQCLATWNNGDKMLYGKFTGKSLAPNENMYRCMIHEFWGSEGDLSMSVDASCQGPQSAHVGPFTMDLKRIHDNIYHSASIYSYLSIYLSIYLSIYLSIYVFMRVFLMYVCVSFSISVYLSIYLSMPDFSYINLYKYLFVYACFFHISIYLSIYLSIYLSIYLSIYSCEFFNVCLCQFLDIYLSIYLSIYLSIYASFFLYLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ASG6</accession>
    <name>A0A812ASG6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_3573</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000107">
        <property type="protein sequence ID" value="CAE1152778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ASG6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1152778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="271" mass="32382" checksum="5875A21F4843AA4A" modified="2021-09-29" version="1">MKVIILPLLLSCPTHYLSISLSINEGAENNIFFLTFPSFVRSFFFFFFLPFVLSCFLTFVLSSVRSFFLSFFRFISFFLLFIRSFSRSLIHSFFLSTVRSFLLSFFRSFVLSFFRSFFLSIVRSFFLLFLLSFVLLFCFVFRYFVLFLPFVLSFFLSSISSFFLSFRSFFIFLYSACSFVLSLFRSFVLSFFLSFFLPLVLSFRSFFRSFCHSFLCSFFLSFFQAPIWDEFCFLMHLNLFLCRHLNTNPFLSIYLSISGCRHLSIYLSIDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AW58</accession>
    <name>A0A812AW58_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NPHP3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SPHA_6367</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
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</entry>
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</entry>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="546"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1164769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="615" mass="72647" checksum="CDE2195E2820254F" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B0D9</accession>
    <name>A0A812B0D9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_8832</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000286">
        <property type="protein sequence ID" value="CAE1166293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B0D9"/>
    <dbReference type="OrthoDB" id="6161701at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1166293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="155" mass="16757" checksum="118EC56878A22BD4" modified="2021-09-29" version="1">MDILFPTSEVSFTIDAKALITATSLPDSVTLAFTGILENGGRFSPDSTLCTTPIVSSCACLTTEMASAGGDLSSRMVSVSRELTVDKKQLSVYKRKRSSAPDDRNSAKAIGFVALLVLAFPVAYIILTDLSNYRKFLPGNELKRISTKEKQIENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B2W1</accession>
    <name>A0A812B2W1_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7041 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_11884</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000396">
        <property type="protein sequence ID" value="CAE1172047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B2W1"/>
    <dbReference type="OrthoDB" id="192611at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055469">
        <property type="entry name" value="DUF7041"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327">
        <property type="entry name" value="ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327:SF3">
        <property type="entry name" value="RNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23055">
        <property type="entry name" value="DUF7041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7041" evidence="1">
        <location>
            <begin position="129"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1172047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="253" mass="28571" checksum="176E13EC2F482EDD" modified="2021-09-29" version="1">MFSCSFETYGLNSTTLSLPMCEYSTLCYFNCTKTEKDIPYQTLRRLLGIASLSSLLGTTESSGHALSRVCELKCKNCPQLQFCTGEVVKDHCGCCQMCSSDLYQPHVRLTPLPNKNNACEKVKCPKFKTWFLQLDAIFQARHITSLQSKFASVVEKLPAKVVAEVADILTSLPIDKPYETLKQAILHRSGFSEERKIRDLLTNVSIGDSKPSQLLRRMQQLLGDNNISATVFRQMWLDKLPSDMVLGCINRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B3M5</accession>
    <name>A0A812B3M5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_10739</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000351">
        <property type="protein sequence ID" value="CAE1169784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B3M5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="333"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="385"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="414"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1169784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="449" mass="54621" checksum="05C04A6C93B2FD7B" modified="2021-09-29" version="1">MPRNNSQLFDYLICCIHSFDSTVSLSSYSSDFLFFFFLPIFLRLNHSFFLIILYYFSFFLISFLLKQLQLINDFLLFLFHILLLVPFYLTFSFISGFLFFSFLFNLSLVFLSFIIAYSFIFLSAFCHSVILSFFFLSVIYSFFFLSSFLSFFTYVLFLFLFLTFLSSFLLTFFAHLIFLFRFYLSFFLSFFFLSFFFLSFPFNCPLSFLVSLFSRFLHIIIFIRFFIFLSFFFDFTFSFSFTITFFLSFFLVLVYKTLFICFAFDFVFLFLYFSFSLSYFLPYFLHAFFPFFPFFSFFLSFFNHLTRFFFLSFFLSFFLSFFLSFFLRSFDPILLSFFLSFFLSFFLSFVRSFFLSFFLSFFLSLFLRPFDPILLYSFFRSFVRSLFHSFFLSFFLSFYLSFFLSKTTCPDSSFFLSFFLSFFLSFFLSFFLSFFLSKTTGPHSSFFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B3U0</accession>
    <name>A0A812B3U0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_9740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000312">
        <property type="protein sequence ID" value="CAE1167959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B3U0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1167959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="229" mass="27838" checksum="EC7679487EC73A9E" modified="2021-09-29" version="1">MLTWQVLRICRLIQRLSEYFSFFLSFFLSSFLSFFLSFFLSIILSFFLSHLLSFFLSFFLSFFLSFFLSFFLLFFLSFSSAFFLSFFLSFFLSFFLIYHHFSFFLIYYFLSFFLSFFQCIPCLSLSFSFFLSFFQCIPCLSLSFSFFLSFFLSFDAFLVCRHFLSFFLSFFFLSMHSLFFVCHFSFFLSFFLSFFLSFLLSFFLCTPCLLLSFSFSFIYSLFLFFLSQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B4E6</accession>
    <name>A0A812B4E6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_11208</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000370">
        <property type="protein sequence ID" value="CAE1170720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B4E6"/>
    <dbReference type="OrthoDB" id="8197512at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1170720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="232" mass="26511" checksum="F811FE1E825E3197" modified="2021-09-29" version="1">MVRTERELIFLDVQIRPDSVVCSLNTCNKEKINKYNQPYFLNAVRDRYGSDLPIRVVALTRITGVRLPRTKVFDGLRHLMIRRTYALTFQGALRVFSAQGISPAHTTISYVCKIGRGKKPDLRTCLSKRITGVRRPQRVFSAQPFLLGTTNISRQFGRPSKRTNRFGRGLNLNRSQCGGRSTKNDTPSLKSSGPQAIPRLALHGGFDIRRRRQNPVCRGCQIGWPFRERRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B625</accession>
    <name>A0A812B625_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_11160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000366">
        <property type="protein sequence ID" value="CAE1170543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B625"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1170543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="256" mass="27751" checksum="1E6C4AA937A1691B" modified="2021-09-29" version="1">MKAQAAATTSAPRASETHHQRLLHNARNAAATAKSRAIETLDHRHDGQSRDAAATARARAAETLLHMSVRNAMNAATIARLRAVETPAHMRAHQSRDADATATARAAETPLRRSVRNATTAATTARSVRNARNAATTARLKAVETFNRRRARQSRDAAATASVKAAETLLCRSKAAETFHRMRTHQSRDVAATARSRESETELQWATCNARNAAVTSAARNSEGPQPNGAGNKLPNGCYKHGRFLVFLGFQLQPRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B9D2</accession>
    <name>A0A812B9D2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_12554</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000419">
        <property type="protein sequence ID" value="CAE1173305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B9D2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1173305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="285" mass="32958" checksum="62F1C79E153BBDEC" modified="2021-09-29" version="1">MVNLTGPFMGIGWSIHTGPFKNGQSIPDRSWDHWMVMIHRGPFWNWIIHLIMVNPYRTVLGWMVPIRHQPFNGQSAPDRSCLVNQPDRSWDNPCRTVLKLDGQFGWSMRRTIHEVGDFIGFRTVRQELDGQSNRTVLSIHTRTVHGNWMVNSRHNPRTFQEIGRPMVNPYQAVHELDGIHTGPFIGQSRLYNICIIHTGRSLWELDGQSSRPFIGIRWSVNQSITAFAGIGYNSSPYQAVHRKLKSRNLFGWSQMSLLVLVNSWEIIHSSVKIQPPEWSITRDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BCU4</accession>
    <name>A0A812BCU4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_14347</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000490">
        <property type="protein sequence ID" value="CAE1176845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BCU4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1176845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="209" mass="24444" checksum="43642E87F78C814C" modified="2021-09-29" version="1">MDASLVMLDTRKLLFYFLQLNSRNYLSIYLSIYLSIYLSISFYSDPEHKKLSIYLSIYLSIYLSIYLSNESPSYLSIYLSIYLSIYLSIYLTNLLPIYLSIYLSIYLSIYLSIYLTKSVIYLSIYLSIYLSKVSFLSIYLSIYLSIYLSTWSQLFFFIRFVSYFLSASKWTEFCGGCGHFSRIPPSLAPAHALSHSLFRFVFAPEKISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BF37</accession>
    <name>A0A812BF37_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">pseudouridine 5'-phosphatase</fullName>
            <ecNumber evidence="7">3.1.3.96</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Pseudouridine-5'-monophosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SPHA_16328</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Farmed</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>psi-UMP + H2O = pseudouridine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10944"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17802"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58380"/>
            <dbReference type="EC" id="3.1.3.96"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.96" evidence="7"/>
    <dbReference type="EMBL" id="CAHIKZ030000572">
        <property type="protein sequence ID" value="CAE1227252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BF37"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990738">
        <property type="term" value="F:pseudouridine 5'-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07529">
        <property type="entry name" value="HAD_AtGPP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.240:FF:000001">
        <property type="entry name" value="Haloacid dehalogenase-like hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000055">
        <property type="entry name" value="Haloacid dehalogenase-like hydrolase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045228">
        <property type="entry name" value="Gpp1/Gpp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18901">
        <property type="entry name" value="2-DEOXYGLUCOSE-6-PHOSPHATE PHOSPHATASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18901:SF38">
        <property type="entry name" value="PSEUDOURIDINE-5'-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01135">
        <property type="entry name" value="C1.5.6:_HAD__Beta-PGM__Phospha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00052504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00066578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00083904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAE1227252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="392" mass="44441" checksum="E80984B2C873BFB2" modified="2021-09-29" version="1">MATYKPVTHVIFDMDGLLLDTERLYTEVTQKICDDYGKTFTWEIKAQLMGRKEHDSAKITIDQLGLPLTVEEYLKRLRQEEKLVFPSVKFLPGVKKLLTHLHKHNIPMAIASGSCSMKYKWKIVNHQEMFSLFNHVVLSTDDPEVKNGKPAPDCFLIAAKRFPDKPEPEKVLVFEDAPNGVQSGYAAGMQVVWIPDPQADRSLLKDEATLILDSMEDFKPELFGSKVFVFFLFFLCRQSSLPGDQSPFFLHLFSSRPPGYYAFLLRPLEGGNLLKHAVKYFLKAYVFALSSSSQMALAPNSTYGLLFKHSLLELLREDFSKLSLKGKLALSNLLPKHPSLMGKLCLPFQQAERKTPVSQRSRFQLLLRSSPSSPFPFKSGGRSPLNRPITVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BFY7</accession>
    <name>A0A812BFY7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_16082</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000561">
        <property type="protein sequence ID" value="CAE1226580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BFY7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="139"/>
        </location>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1226580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="193" mass="22671" checksum="473C8073A57C069D" modified="2021-09-29" version="1">MIINPSLFYVIRIIFFDNFSVASVLRVLNRFIISSSINIPHYAPLFFLLKKYSLSLSLSLSLSLSLFHFITEFFFSFLFFINVYFIFFRFSSSIIFSILPFIDHIFVSSSSASFFFFLFSSSFFSFFFVLLFFSFFLLFSSSHRVFCKCRIIMHGFRFLSPVSQLGVRLSIYPEAIRDTHPLTSLRQHMTSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BGB7</accession>
    <name>A0A812BGB7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_16135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Lophotrochozoa</taxon>
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            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000563">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BGB7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        </location>
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        <location>
            <begin position="436"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAE1226675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="458" mass="54268" checksum="1CFBD5470155EFF0" modified="2021-09-29" version="1">MSFLQQSSSNKQFLYYVDSSIERIHIFNVIFSYLSIYLSIYLSIYLSYIIIYYIYCLALFIYLCRIPSTESTTSIYLVLVIILSYYNTIYSIYLSIFYYILYYIYLSIYLSIYLSIYLSRSVLNYLSIFLSIYYLYFSLSISLFIYPSHSIHIYLSLFFSLSLFLFLSLSMLGFIILYFYFNYCRFPSLSFFSSSPPPVSSILILFLGLVSLLSPTPSFFLLFLNPPTSHPPFSFCIFLSRTSHLVYSSSFHILAFHKCETHSLFRSIYLSIYLSIYLSIFLSLFLSHFFFLFSHVGLILCLLYEVVLDFKPFFFFLLLFPFLLTCSAFFIFLSFSFINQKFFFENSSSSSSSSLILYFRPLFDSFFFSSSSFFSLLFLHTTLFLFRSMSIPIYPTPHHYFFFFNLFFIFALFSIHIIIIIIIIIIILLLLLLLLLYIYLSIYLSIYLSIYLCVYIGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BGT1</accession>
    <name>A0A812BGT1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BGT1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="667" mass="76583" checksum="E0B454458EE31F6C" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BJX8</accession>
    <name>A0A812BJX8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">SPHA_21809</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
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        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
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    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000802">
        <property type="protein sequence ID" value="CAE1239338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </evidence>
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        <source>
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    <sequence length="413" mass="48209" checksum="0C4819F7BD334DDF" modified="2021-09-29" version="1">MLSKKRPSSEVITKRGFLSCLSTSFPPHSHIYLSIYLSIYLSIYLSIYLSIYLSLFIYVSELISIYLSIYLSIYLSVSEFISIYLSIYLSIYLSIYLSYSHLSIYLSIYLCSYLSIYEREGEIINSGDMKNNSNGQKYTIHYHSLSLSVGMLTIFLFFFLSFFLSFFLSFFLSFFYSYLSIYLSNSVYSYLSIYLSISIYAQITVGLSHLAITISASLLMKAPRYSRPPLPHILRTQDEWHWNYCISSSSSSSSSSFSLDTRLFLPPSFSPARLSSFFFLTFTLYSFILSSPVLSFIYLTFFFLSPRFIPPPSRFFFHLFFFPAPCRRHHNFPFTPHLSALLFLLVSLTFLSFYLRRSCSRVPRRLPIGGPPIVPLNHVLPKSRRNVMVKKVVFYYTYYHFSFSYLSIYLSIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BNP0</accession>
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        <submittedName>
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    </protein>
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    <organism evidence="2 3">
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        <lineage>
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            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000887">
        <property type="protein sequence ID" value="CAE1243620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1243620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
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    </evidence>
    <sequence length="363" mass="43444" checksum="2BF67CE178750424" modified="2021-09-29" version="1">MFLSVIFWLATLYSLFLSQLDTLFASFHLLLAAFRFSFARLRSLLLCSSFFLFSFVRLRFLLFCSSSFSSPLIVFVFFSFARLFSFSPLFVFFPFLLCSSFFLFSFARHFSFLLCSSFFLFSFARLLSFLFCPPPFISSFVTFFLSYFPCFVLFPCFFLFLVFFFLFIVFFLFLVLCSLPCHFFPPFVFLSFFFFFFVFGFYLNNVYPPSLSQLLEFIIFLISHSPLRHFFKPSPFAPCSFLFSFVRFSLLFFPPPCHFQRNFVAFSLSFSFSLCFFLFFSLFFSLFLFVFFSFSLFFSLFLILFSLFFSFFFSLFLILSLSFFLFFSFFLSFLLSFSFSLSFFSFLSFSFYFSFSFFFSFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BNX7</accession>
    <name>A0A812BNX7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_24077</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000893">
        <property type="protein sequence ID" value="CAE1243937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BNX7"/>
    <dbReference type="OrthoDB" id="2140079at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000421">
        <property type="term" value="C:autophagosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106300">
        <property type="term" value="P:protein-DNA covalent cross-linking repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15949">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15949:SF3">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="236"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="327"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1243937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="381" mass="41417" checksum="0A031FF60CA3E7BC" modified="2021-09-29" version="1">MKAEGYNVTRFPEISHAVKTTFPFKCTFSIFIAFIRVYRQLGLYLKERRLCAHPILEVYDDRNIHFIAPLAKQNDFYVEEAKSCATEEQGSDEEDSTNETVSNYSCSASEQSGRSFSTFSTEASDLSTTTTATGTACFNSSSLSGFTDSSKSVSREKSLTPAMENPIKEEQQEMVEAISVASPLLVKAESSPVSVDDDQEWENLGDFRPQDEEELEASIPPAQEIATTPATPDSADLVLLGNLQDGQLQDEDVSPSKEMTPLLQQEDKNLLQNSVASNLEESGFSESVMSTLQDSGLGTEESSATDPQLAAAGRSNTPVDVVAPATLPLQLPLQPSSPPQQQQQQQPQSPQLVEIESDTASEHSTGSSSYEEVKLAEVTDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BQL2</accession>
    <name>A0A812BQL2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_21038</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000775">
        <property type="protein sequence ID" value="CAE1238038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BQL2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1238038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="253" mass="29479" checksum="C3D7A7337FF6783F" modified="2021-09-29" version="1">MCAWVNYHNTIYLSIYLSIYVSVHIYLSIYLSIYLSIMALLGPEINTQERKGLGGSMCAWINYHNTIYLSIYLSIYLSIYLSMSLFISIYLSIYLSIYLSIYLSIYYGLLGGSMCAWINYHNTIYLSIYLSIYLSMSLFISIYLSIYLSIYLSIYLSIYLSIMALLGPEINTQERKGLGGSMCAWVNYHNTIYLSIYLSIYVSVHIYLSIYLSIYLSIYLSIYLSIYLLWPLLYLSIYLSIYLSIYLSIYLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BS17</accession>
    <name>A0A812BS17_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_21844</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000802">
        <property type="protein sequence ID" value="CAE1239316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BS17"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="324"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="419"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="443"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="483"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="523"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1239316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="577" mass="67257" checksum="839B4456703621FA" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BTV0</accession>
    <name>A0A812BTV0_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SPHA_23982</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000890">
        <property type="protein sequence ID" value="CAE1243757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BTV0"/>
    <dbReference type="OrthoDB" id="9998912at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056737">
        <property type="entry name" value="Beta-prop_ATRN-MKLN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051568">
        <property type="entry name" value="LZTR1/Attractin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016201">
        <property type="entry name" value="PSI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46376:SF2">
        <property type="entry name" value="DISTRACTED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46376">
        <property type="entry name" value="LEUCINE-ZIPPER-LIKE TRANSCRIPTIONAL REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24981">
        <property type="entry name" value="Beta-prop_ATRN-LZTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23106">
        <property type="entry name" value="EGF_Teneurin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00423">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="694"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="732"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="762"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="796"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="824"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="856"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="887"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="922"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="956"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="996"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1030"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="7">
        <location>
            <begin position="42"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAE1243757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1053" mass="113144" checksum="93E5280003A21F86" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C178</accession>
    <name>A0A812C178_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_26597</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001016">
        <property type="protein sequence ID" value="CAE1249470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C178"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="307"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="382"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1249470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="425" mass="49138" checksum="FB060BAB1566C4FB" modified="2021-09-29" version="1">MRLLCRNRYLRKILFVRFINKIRLIFAAHSVSLSIFLSLYPSLSLFFVSRCLLRHLLSLTFSSSIKSTPLSIYLSLLNIYLSIYLSIYLSIYLSIYLSESVQYLSIYPSIYLCLLNIYLSIYLSIYLSIYLSIYLSIYLHLLNIYLSIYLSQSAQYLSIYLSIYLSIYLSQSAQYLSIYLSIYLSIYLSLLNIYLSISVCSIFIYLSIYLSESVQYLSIHPSIYLCLLNIYLSIYLSIYLSIYLSISSAQISIYLSIHLSIYLSIYLSQSAQYLSIYLSIYLSIYLPFSVSLSLTCPFSFYSPFLSLYLSLTLLRSFSIFALFTFLSLPLPLPLSIFRFHLLSLSLSLSLSLSFSLSVHLIFQSSFPFFFTVPPSLPISLTPSLSLSNFLPFSLSIYISHSTTHIHFSHTHTKTEREREREGMCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C269</accession>
    <name>A0A812C269_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_29957</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001202">
        <property type="protein sequence ID" value="CAE1256020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C269"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1256020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="197" mass="23190" checksum="E0B900DBB7765659" modified="2021-09-29" version="1">MHLILILLQLVFSFPSYLYFSLFFSPILPFCLSLNLFLFLLTFSLLLPALYLSFFLFLSFFLFHSSPIIYLTPSLLPRFLSLFFSPIFSIIFSLYLFTSLSFFLLLSQLLSRFFLSFALSLSFPILLFLFLFFFHLPFLSLSFSFSLSSLHVFFSSFSLFLSFSSFFFVFLFVFLTYFLSILLFLSHLILSPRQISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C4B6</accession>
    <name>A0A812C4B6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SPHA_29242</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001161">
        <property type="protein sequence ID" value="CAE1254905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C4B6"/>
    <dbReference type="OrthoDB" id="6126739at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050579">
        <property type="entry name" value="PMP-22/EMP/MP20-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004031">
        <property type="entry name" value="PMP22/EMP/MP20/Claudin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10671:SF108">
        <property type="entry name" value="CLAUDIN FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10671">
        <property type="entry name" value="EPITHELIAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13903">
        <property type="entry name" value="Claudin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAE1254905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="210" mass="23988" checksum="0057AAC2266AB302" modified="2021-09-29" version="1">MSQGQKTWAFISIFLCFVSFGLICTSIGTSEWFQTTQNTTNYTVVTDIGLWKICVSEIKQDGWTRKICTYRDLTESRDKTSSGFLQLRLDQCFVIFICLCAFIQLLTHLILLWSLPGCCKSMKKTHLFFIVSVTQLLAVLVGIIGCISFIALQDEIHKSDSSQQYTYQWSFILAWISIALCLLESGIFVVLVKVCFDNVFQSGKFNYYSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C4Y3</accession>
    <name>A0A812C4Y3_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SPHA_28367</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001112">
        <property type="protein sequence ID" value="CAE1253256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C4Y3"/>
    <dbReference type="OrthoDB" id="10011262at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14978">
        <property type="entry name" value="7tmA_FMRFamide_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052954">
        <property type="entry name" value="GPCR-Ligand_Int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641:SF2">
        <property type="entry name" value="FMRFAMIDE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641">
        <property type="entry name" value="FMRFAMIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAE1253256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="388" mass="44349" checksum="452B69425CD1542C" modified="2021-09-29" version="1">MRSSTNCYLRALAVWDSVVLIVTLFLIGIPSVSESYDANIKPFVVVYIYPAALVAQTATIWLTVSFTVERYIAVCHPLRAASMCTIARARIVILAVSVFSFIYNASRWFEYEIVYQLDPNNETLQVMGSMTDMGRSKVYHKVYFLCLYLPIMCFIPLTSLAVINIFLILAVKRSQRQRRDMNVRQSRENNVTLMLVSVVVVFMICQVPALIYNMAYAIDTKTVAEKYAWRIVSILRNYLVTLNSAINFMLYCAFGQKFRRIFIRTFCQCLLSEEDFSSLTYHGTVINQHSTTGKYCKMQKGNRTTPDVIDMTSSTTAAHASVLSRYSSHSSFDANSLFRKNLLNKSGNEHRVKTDDREDIFCDKNGIDEKEILKDDKAEIIDSDKNDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C5Y4</accession>
    <name>A0A812C5Y4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_29022</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001147">
        <property type="protein sequence ID" value="CAE1254459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C5Y4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1254459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="265" mass="30751" checksum="53F986EF4D762BFC" modified="2021-09-29" version="1">MHTVSIRFKKTKKKKHRFKESVHNFPKSSIQSAPSVKALIQEDGAPSVKRSIQEDGAPSVKRSIQKRFDSRVHPPCASIQGRCTLHLSLRFKRTVHTPEIQGARCTFRQRRFKENMHTPLKRFDSRGRCTSVKRFRFKRTVHLRETRLFKDGAPPLNARFKRTVHPPNKSIQEGRCTLRETLDSRGRCTLRETLDSRGRCTLRETLDSRGRCTLRETLDSKHSIGPSIQGIVDTSLYGCRIFQSQLSMKLPKRSWDIKKSRNFQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C6C2</accession>
    <name>A0A812C6C2_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Mediator of RNA polymerase II transcription subunit 14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">Mediator complex subunit 14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">SPHA_27831</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">Farmed</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Mediator complex subunit 14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001090">
        <property type="protein sequence ID" value="CAE1252089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="205099at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056877">
        <property type="entry name" value="Med14_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055122">
        <property type="entry name" value="Med14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055113">
        <property type="entry name" value="Med14_RM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055114">
        <property type="entry name" value="Med14_RM6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055107">
        <property type="entry name" value="Med14_RM8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013947">
        <property type="entry name" value="Mediator_Med14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056879">
        <property type="entry name" value="RM3_Med14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056878">
        <property type="entry name" value="RM5_Med14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12809">
        <property type="entry name" value="MEDIATOR COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12809:SF2">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08638">
        <property type="entry name" value="Med14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25069">
        <property type="entry name" value="Med14_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22981">
        <property type="entry name" value="RM2_Med14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25065">
        <property type="entry name" value="RM3_Med14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25067">
        <property type="entry name" value="RM5_Med14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22984">
        <property type="entry name" value="RM6_Med14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22983">
        <property type="entry name" value="RM8_Med14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0010">Activator</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit MED14 N-terminal" evidence="13">
        <location>
            <begin position="13"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Mediator of RNA polymerase II transcription subunit 14 RM2" evidence="14">
        <location>
            <begin position="280"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Mediator of RNA polymerase II transcription subunit 14 RM3" evidence="17">
        <location>
            <begin position="360"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Mediator of RNA polymerase II transcription subunit 14 RM5" evidence="18">
        <location>
            <begin position="642"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="domain" description="Mediator of RNA polymerase II transcription subunit 14 RM6" evidence="16">
        <location>
            <begin position="768"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="domain" description="Mediator of RNA polymerase II transcription subunit 14 RM8" evidence="15">
        <location>
            <begin position="1224"/>
            <end position="1297"/>
        </location>
    </feature>
    <feature type="domain" description="Mediator of RNA polymerase II transcription subunit 14 C-terminal" evidence="19">
        <location>
            <begin position="1313"/>
            <end position="1457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="949"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="436"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1011"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1040"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1123"/>
            <end position="1135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF22981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF22983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF22984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF25065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF25067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF25069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CAE1252089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1460" mass="162383" checksum="E40B60F9038A6A7C" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C7A1</accession>
    <name>A0A812C7A1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_30886</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001247">
        <property type="protein sequence ID" value="CAE1257606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C7A1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1257606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="415" mass="49502" checksum="4E0EDB9F08B7F45B" modified="2021-09-29" version="1">MFHLLLYFFFLFFFFLSFFLSFFLSFFLSFLFPTLHSFLRSFVFFFFFFLHPSFFFTFLLKSFSYFLLSFLSFFLLLFFLCILSPYLSFLFSFFPYFLFLSFFLSFFLYFSLPFFLSFFISFFLSFFLFLSFFLRSFVFFFFFFFLHPSFFFTFLLKYFSNFLLSFLSFIVFLCILSLHLSFLFSFSSLLSLSFFLSFFLSFFLSFIAPYPSSFFFLFFFFFILLLLLSYFFLTSVFLFYPLSNCLLWLSPIVFCPSSLLLFLFYLIIIIIFNHPLFPFYLFLPSFLPSFLPSFLPSFLPLDFSRHPFPHPSIQNNIHKKNFPSTLASFHIFPSTPSVQRPLEADEELLRSALSPIDRTKDFFFIVFCQFVPSAAAGECALVKVPAAELSSPSLFRGKQPPSAPIFLVCFQPSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C9N0</accession>
    <name>A0A812C9N0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SMEK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SPHA_30869</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMEK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001247">
        <property type="protein sequence ID" value="CAE1257652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C9N0"/>
    <dbReference type="OrthoDB" id="27483at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030289">
        <property type="term" value="C:protein phosphatase 4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072542">
        <property type="term" value="F:protein phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000051">
        <property type="entry name" value="Serine/threonine-protein phosphatase 4 regulatory subunit 3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055236">
        <property type="entry name" value="EVH1_PP4R3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006887">
        <property type="entry name" value="P4R3-like_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051137">
        <property type="entry name" value="PP4R3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23318">
        <property type="entry name" value="ATP SYNTHASE GAMMA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23318:SF0">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22972">
        <property type="entry name" value="EVH1_PP4R3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04802">
        <property type="entry name" value="PP4R3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="PP4R3 EVH1-like" evidence="7">
        <location>
            <begin position="62"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Serine/threonine-protein phosphatase 4 regulatory subunit 3-like central" evidence="6">
        <location>
            <begin position="189"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="623"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="785"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="623"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="642"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="711"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="803"/>
            <end position="813"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAE1257652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="813" mass="92393" checksum="21A01C2284021F5C" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CAY6</accession>
    <name>A0A812CAY6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_32562</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001358">
        <property type="protein sequence ID" value="CAE1261177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CAY6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1261177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="226" mass="27066" checksum="5F23081C24B1F186" modified="2021-09-29" version="1">MSVCPRRNDSSTPTRVYLSLFPSTFFLLCLFVCLFLSFFLSFFLSFFFPISSFFSFCIKFFLSFFLSFFLSVRFSLFVLNSFFLSFFLSFFLSFFLSYKHLSLLFISIGILYSFLHQSLSLFFPLLSFFLSFFLNFVFLSIRFSICINHFLSFFLSFFLSLFLSFFLSFLILFFYQFVSLFASIIFFLSFSLSFFLSFFLSFFLSSHMSSRLSRVYSLTFYKQLQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CDF0</accession>
    <name>A0A812CDF0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_32251</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001335">
        <property type="protein sequence ID" value="CAE1260299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CDF0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1260299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="196" mass="23861" checksum="82F0CA2F9A1096E1" modified="2021-09-29" version="1">MRTCTQNKSTYSFFLFPFAYFYLYFCCFFFFFLLFFVFCLYSFTHFFLSFVSIILSLFSTFFLFTFTFSFSLHCLFFLTFLPLSLFILELSFLLLLFILPTSHKPYIITLVKQLCINHLSFFHSLFTTFFIFSLSHFLFYLLCFFLSYCFLFFASLFFLSLFLSFFLSFFLSFFLSFFFISFFLSFFLSFFLSTLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CDK0</accession>
    <name>A0A812CDK0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_33290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001392">
        <property type="protein sequence ID" value="CAE1262547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CDK0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1262547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="205" mass="24782" checksum="1EABB53AF8BFC054" modified="2021-09-29" version="1">MLFLSTSLLSFIFSFFDFIASFFLFIFIFFFLFRIFIFENSLLFLILFSFHLKLNYCFLSVLFPFIHVHFFSFSSVPRFLFCVSFNCCFILSFIIYFFISFFHFCSSFLFYLALCAFLSFHLSFFHSSFYFKFISFFLSFFLSFFLSFFLPSLFPHVHSVFGVSFLVSFFLSLLDLFLIYFFTPVILSFFLSFFLSFFLSFFLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CFN5</accession>
    <name>A0A812CFN5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_38350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001735">
        <property type="protein sequence ID" value="CAE1273636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CFN5"/>
    <dbReference type="OrthoDB" id="6132405at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032832479" evidence="2">
        <location>
            <begin position="23"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1273636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="224" mass="24897" checksum="ECD346560CAA27B4" modified="2021-09-29" version="1">METVRAVMLVAIAFSLIVGINGYCNLQHELQDCVDILQPGIQFKDITGNQPTWNRTQLDHACSHLTGFFQCYDDTVIKCNDESLRKVKIIFTKTFGYICGDGRELYLKTHVCLNQEPVKSNVKECMSYAHSPHFIQTKDDACDKINDLTRCVERAAAPCGEDSKAFLTGFIKRILDGLINCGGLSHGIIAAIIAAVCVTVVLIAFVIKALIQRKSNTSFERMES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CH17</accession>
    <name>A0A812CH17_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_33445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001401">
        <property type="protein sequence ID" value="CAE1262878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CH17"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="370"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="400"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="430"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="462"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="490"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="517"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="552"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="576"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="603"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="634"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="665"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="691"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="716"/>
            <end position="736"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1262878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="737" mass="90030" checksum="1979D17D6D752278" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CJC2</accession>
    <name>A0A812CJC2_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="2">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">SPHA_38628</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">Farmed</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="2"/>
    <dbReference type="EMBL" id="CAHIKZ030001763">
        <property type="protein sequence ID" value="CAE1274088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CJC2"/>
    <dbReference type="OrthoDB" id="546826at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00603">
        <property type="entry name" value="IPT_PCSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000554">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1680.10">
        <property type="entry name" value="ligand-binding face of the semaphorins, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002165">
        <property type="entry name" value="Plexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016201">
        <property type="entry name" value="PSI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036352">
        <property type="entry name" value="Semap_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF564">
        <property type="entry name" value="MACROPHAGE-STIMULATING PROTEIN RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01437">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01833">
        <property type="entry name" value="TIG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00429">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00423">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103575">
        <property type="entry name" value="Plexin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101912">
        <property type="entry name" value="Sema domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="760"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="865"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="898"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CAE1274088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1150" mass="130888" checksum="1F8F8717C40CCD0D" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CL43</accession>
    <name>A0A812CL43_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_36687</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001613">
        <property type="protein sequence ID" value="CAE1269604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CL43"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1269604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="214" mass="25480" checksum="AEDFEDB8EE817B39" modified="2021-09-29" version="1">MRMYTLLLLFSVQFFLSFSLSLSLSQCFFFFLDFYLSIYLSIYLSIYLNSISFLISIYLFKVFSFLIFIYLSIYLSIYLSLSYHLSISYYLIYLSIYLSTYLKSISFLIFIYLSIYLSISFLPSISYYLSVYLSIFLNQSIYLSSIYLSIYLSMQGAVRASHLSIYLSIYLSIYLSIYLSIYLLGILSIIQSIYLFIFFLLHIYLYVCFFTMFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CL96</accession>
    <name>A0A812CL96_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_36682</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001613">
        <property type="protein sequence ID" value="CAE1269711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CL96"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="280"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="310"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="334"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="369"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="393"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="459"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="485"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="512"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="545"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="574"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="602"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="625"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="657"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="689"/>
            <end position="717"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1269711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="719" mass="86800" checksum="9B320A905D7B6B47" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CPK8</accession>
    <name>A0A812CPK8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_39442</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001832">
        <property type="protein sequence ID" value="CAE1275397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CPK8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1275397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="187" mass="20864" checksum="FA8AAC5F62A7BA50" modified="2021-09-29" version="1">MRDKPVASVCLFSLFPLSCRYTNRRGLYFFVFDCLCTGTSDLQKYSSHDGSAPLLKTLSPFLSFFLSLSLSLSLSLTLSISLFLTLSFSPSLCIIWTTKRKIKAKHPFVMSVCVSSSIVTLPRPILNCSLSLSLSLSLSLSLSLSFFLAHFVSNYLFYLPTKLSVCLSMLLRGKGLNKINSWSLRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CPU4</accession>
    <name>A0A812CPU4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_37784</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001692">
        <property type="protein sequence ID" value="CAE1272664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CPU4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1272664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="244" mass="29608" checksum="7080E4E8A76975EC" modified="2021-09-29" version="1">MSRNLLSLSLSLSLYLSIYLSIYLSIYLSTFYFKKTLTSYFPTQYLSIYLCIYLSIYLSVCLEHTHILPLSPYLYFFLSLSSLSLSLSLFFILSLLLCILSIVFYIFFFFFLFFLRFCLFFSTFLSFFYLSDFLSFFFILFLSFRFSFMLILRCLYIFFSFFGLFILFFFFSYHLSFTFFLSFFFVSLFFLSFSRHLLSFFFSPLFQCLYPLLVTFKNFSFFPTFFLSFFFSSSFFLSFFCFIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CR93</accession>
    <name>A0A812CR93_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_39577</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001849">
        <property type="protein sequence ID" value="CAE1275625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CR93"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1275625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="305" mass="36050" checksum="2F9233A63AB98438" modified="2021-09-29" version="1">MKVVRFFTLPAHFCHLHPPCLSTIVTFTLPACPHLSHSPSLPVHICHIHPPCLSTIVTFTLPACPHLSPSPSLPVHYFTFTSLPVHYCHIYLPACPLLSFHPPLPVHYSHIHPPCLSTFVTFTLPACPLLSFPLPSLLFSFLTNLHYYKFLSFLFQNSFEDPLHFFFFFSFSSFLFSFFPLFSFPLFLFFSFPLFSFPLFPLFFSFLSFFLFSSFFSFLFSFFFLFSLTSLSSFLFFLFSFLFSLFLFSFLFSSFFIFSFFLFLFLFSLFPLFLSLFFFSSFFFFFFFFLFFLFLFPLLPLYILF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CS69</accession>
    <name>A0A812CS69_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="13">TMEM38</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SPHA_40736</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM38 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001935">
        <property type="protein sequence ID" value="CAE1277564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CS69"/>
    <dbReference type="OrthoDB" id="195817at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005267">
        <property type="term" value="F:potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007866">
        <property type="entry name" value="TRIC_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12454:SF11">
        <property type="entry name" value="GH25683P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12454">
        <property type="entry name" value="TRIMERIC INTRACELLULAR CATION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05197">
        <property type="entry name" value="TRIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="6" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAE1277564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="201" mass="22724" checksum="BA862C27BB1FBD25" modified="2021-09-29" version="1">MIPFKNHRDILTATAVWYLIFYSPFDIVYKLVKFLPFKLCIGTLKETQRAHKVYHGVTHTAKLYPQAYLLIVIIGTVKGAGSGIMKTIDRLIRGVWIPGSNEFLQPSFYTKACLIASIIFVLERTAVIVAPHAFIYFGVVIFFVYFKLSSLLLGIHDPFIPFENLFCAIFLGGMWDALRRAISKEAPEDANGKSKADKKND</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CS81</accession>
    <name>A0A812CS81_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_42450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002081">
        <property type="protein sequence ID" value="CAE1280671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CS81"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1280671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="173" mass="20212" checksum="A294E8439425CEB5" modified="2021-09-29" version="1">MFQCIYLCIYLSIYQSIDLSILVPMSTYLATFDCTLLSTDLCIIEHGHLSIYLSIYLSIYLSIYLSLSLSLYIYIYIHILNCFYLSIYLSIYLSIYLSIYLSIYLSLFILSLSTDPTSIFLSLIFPFPLFLIPFHFSDLLIHFFTILSSICLSFVEAVLSHYCPFFFPLHFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CTE0</accession>
    <name>A0A812CTE0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transmembrane protein KIAA1109,Transmembrane protein KIAA1109 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_40699</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001932">
        <property type="protein sequence ID" value="CAE1277521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6151673at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048488">
        <property type="term" value="P:synaptic vesicle endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033616">
        <property type="entry name" value="BLTP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056742">
        <property type="entry name" value="BLTP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31640:SF1">
        <property type="entry name" value="BRIDGE-LIKE LIPID TRANSFER PROTEIN FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31640">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN KIAA1109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25040">
        <property type="entry name" value="BLTP1_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01220">
        <property type="entry name" value="FSA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <feature type="domain" description="Bridge-like lipid transfer protein family member 1 C-terminal" evidence="2">
        <location>
            <begin position="788"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="683"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="738"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="412"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="683"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="706"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="760"/>
            <end position="769"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1277521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1376" mass="151086" checksum="1E4F0159FF116A18" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CUI4</accession>
    <name>A0A812CUI4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_42234</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002056">
        <property type="protein sequence ID" value="CAE1280282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CUI4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="461"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1280282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="531" mass="60426" checksum="5FC380D391FF64D2" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CVB4</accession>
    <name>A0A812CVB4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_40849</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001940">
        <property type="protein sequence ID" value="CAE1277760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CVB4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="286"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="318"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1277760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="336" mass="39190" checksum="4B087F00F7FBA3D9" modified="2021-09-29" version="1">MDYITFSYLFRFNHLFSHPKKKCFVCYGKENLCRLSLSLFHLFSSSSGSINSKWQKIRILTVASSSSSHLNVYFNAIYLLSINSYILFNLLFLLFPIRRVSIYLSISSLSIYLSIFLSIYCIYIYIYLLHIYLSSSFLLLSLSLVSSSVYRLSSSSIYLNILTVLSLFFFQTIHSSIYLSQILVHCLSIYLSIYLSIYSFFLSRISLFFICEKYLSFTSLSRTDLSIYLAYFLCFSFSSLFYLYLSLFLCLFIHLSIMSAFKIIYLSYNSSSFSLFLLLPISSSSLFNFTAISISSFHFLFSFLYCFSLFFICEEYSIHLHLSVLSFSLLFPLLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CWF5</accession>
    <name>A0A812CWF5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_44915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002304">
        <property type="protein sequence ID" value="CAE1284718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CWF5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1284718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="255" mass="30601" checksum="862CEE7F4B926EF7" modified="2021-09-29" version="1">MHINISSFFFFFPVYFFSHSTLSYFHSISFLFLSFFLTFFLSFFFLTFSLSLSFFLSFFLLSFFLSFFLSVFLSFFLHFSVSLSFSLSFCLSFSLSFSFFLSSFLTFCLYFFLSAFFLSLCLSFSLFFFLSFFLSLSLFFLSFFLPLFLSYFLSYLLSVCISFFLSAFFLSFLLSLFLLFFLSFFLSLSVFLSFFLTYFLSVFRSFCHFVCLSFFLSFFIYLFRSFILSFFLSFFLSVFLSVFLPYFLSFFFLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CY61</accession>
    <name>A0A812CY61_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_42369</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002068">
        <property type="protein sequence ID" value="CAE1280473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CY61"/>
    <dbReference type="OrthoDB" id="6425635at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786:SF74">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786">
        <property type="entry name" value="DNA BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1280473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="476" mass="52716" checksum="80EFD7D5DF72AF62" modified="2021-09-29" version="1">MGAFSGARVIPPLLPLRTASIHALTQQDTQYSLRETGHCHSLFIHLMFVWGGHGHSYRFFPPPLITAISTLKCKCTQGQPPLLRDSGVPLSLADRFNRGWTHLSLSLSLRESGHCHSLFIHLIFTLFDVFTVWMSPKRRKLLGRLTAAASTARTARASETPEQTSLCLSWMALSSAACLSTESAAVRTERLASVASTMSARCTRLSVEERSLQNSQGAVRVARLRASQSPAQKTLRHLRDAIANACSSGLESPKQTTSHHHRNTRATVASRASEQPQETAHCRVINACSTASARALESLAQTTVRRVRNAHPTASARAAENSEGEPPQFLQIYFLADYNEQVDACLGILPTDFSVGRRRDILFHLQDMLHETNSYIQSLKFVLQNNSSPSFSVVIDADRPLHSEHERRFIAPACNEVATVIHGEKHNSRDIVIKYQSGGLRASVKPTVHRLSPVPLLFSIRKRWIPLQNPNIPGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CYY6</accession>
    <name>A0A812CYY6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SLC7A4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SPHA_43440</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002179">
        <property type="protein sequence ID" value="CAE1282384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CYY6"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029485">
        <property type="entry name" value="CAT_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43243:SF4">
        <property type="entry name" value="CATIONIC AMINO ACID TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43243">
        <property type="entry name" value="INNER MEMBRANE TRANSPORTER YGJI-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13906">
        <property type="entry name" value="AA_permease_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="346"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="430"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="461"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="495"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="520"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="domain" description="Cationic amino acid transporter C-terminal" evidence="7">
        <location>
            <begin position="493"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAE1282384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="542" mass="58826" checksum="A97FEDBB8767166C" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D1M9</accession>
    <name>A0A812D1M9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ALKBH8</fullName>
            <ecNumber evidence="5">1.14.11.-</ecNumber>
            <ecNumber evidence="5">2.1.1.229</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SPHA_45857</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Farmed</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.-" evidence="5"/>
    <dbReference type="EC" id="2.1.1.229" evidence="5"/>
    <dbReference type="EMBL" id="CAHIKZ030002390">
        <property type="protein sequence ID" value="CAE1286191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D1M9"/>
    <dbReference type="OrthoDB" id="271595at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032451">
        <property type="term" value="F:demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106335">
        <property type="term" value="F:tRNA (5-carboxymethyluridine(34)-5-O)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070988">
        <property type="term" value="P:demethylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032857">
        <property type="entry name" value="ALKBH4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12463:SF1">
        <property type="entry name" value="2-OXOGLUTARATE AND FE-DEPENDENT OXYGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12463">
        <property type="entry name" value="OXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="268"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="346"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="44"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAE1286191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="371" mass="43042" checksum="84DDB0285FA8C339" modified="2021-09-29" version="1">MAAPIVVNAAYSVDKKIIKKLNRCRHTLRKLDNIDISEEATNILCVFNGGLDTGVCREELEQIFSQDASIENIIMLPKRPYSFVYYLQVEEAVQVCNKLNGARLSNGSHLYISYVKQVPVCSYPSGDFPPGLILKKDLISENYEKQLLELANWDYQDLKAENTLKHRRVKHFGYEFKYGINNVDPDNPLPERIPKECDAILLQLQRLGLISHYPDQLTINQYLPGQGIPPHIDTPSAFEDGIVSVSLGSQVVMDFQHPDGRHRSVPSFFLLLFLFSYSLFLIHFLSFSFILSIFPLIFSFFPTDSFFSPFPFTHSFFSFLFFFHLFFYSFTFLIHSFFSFLFYPSIFFFSSSLFVLFFLLFPFTFIIFCTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D215</accession>
    <name>A0A812D215_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_44642</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002280">
        <property type="protein sequence ID" value="CAE1284206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D215"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1284206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="312" mass="36383" checksum="66C63CD09B4CE521" modified="2021-09-29" version="1">MSLVDRRPFQDSRGRMAHYTITPAQRVLDSLSLSLSLSLSLSLSLSLSVHRPLVRHSIPIDNVSLSFFRLIRNLHSGEVSIITTLFTGFLSPLSTILFFQTNEIFLFPFLFLFSFLSPYFFYFLQLLNLSLLPRFLSLAFNFPFICDFLIFLVIFSFTFNLIFSSSFFFVVVFRSLCSISFFLLFLSFFSFFLSFFLSYFSQYICVQFLCLIFSFFSLFFSLLFDLSWFNIFFFLSFFIFSLLFCSYPCLFVIYLSIYLSIYLSLSLRYLSIYLSILVSSLSIYLSQFLHISPSIDLLPSPPVPNFLAISLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D3B3</accession>
    <name>A0A812D3B3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_44488</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002277">
        <property type="protein sequence ID" value="CAE1284121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D3B3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1284121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="196" mass="21270" checksum="D5683EE6BF355F8C" modified="2021-09-29" version="1">MAILCAFDKDLFFDKFFFKKNFFILYISLYTASSNIFPLSLRCLPLSLSLSISLCSLSLSLSPSISLSLLNSLSLSANKFSLSLCLPTFSLSALPCFSLSAFFSLSLPLSLSLFPSLSLSAFYSLSLCLPRSLSLCLPRSLSLCLPRSLSLCLPFSLPPSLSLSLSASLALSLSLCLPRSLSLSRFCFIRICMGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D531</accession>
    <name>A0A812D531_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_47670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002605">
        <property type="protein sequence ID" value="CAE1289464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D531"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
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        <source>
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        <source>
            <dbReference type="EMBL" id="CAE1289464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="284" mass="33453" checksum="EE58B10F9BB1D061" modified="2021-09-29" version="1">MPSFLSSLSFSFFFFFSSFLSNSILLSFFLFHIISFIPSFFLIFFLFICFFLSFFFILYILSLFLPSSFLLSSFSFLFLSFFSYSFFLSFFSPKFFLSFFLSFFLSFFTYSFVLSFFLSFNFSLLFLSFFHFFFFSFPPFLSFFSLFTVSLAISIYLSIYLSIYLSFSRRNSLAVRSQTAIRSPSEADLLLFRKNVLLTSIWLSHLSIYLSIYLSIYDINKLIATSGTASVFTLILPMFVFVLVASVYRKIFLLWLLTPCQQLDKYHLPLSASRYFAGDRQRPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D715</accession>
    <name>A0A812D715_ACAPH</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_47344</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
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            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="CAE1288719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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            <end position="56"/>
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    </feature>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="109"/>
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    </feature>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="162"/>
        </location>
    </feature>
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    </feature>
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    </feature>
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        </location>
    </feature>
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    </feature>
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        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
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    <sequence length="699" mass="83248" checksum="CF16DF480C5FEB8F" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D749</accession>
    <name>A0A812D749_ACAPH</name>
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        <submittedName>
            <fullName evidence="5">CALM</fullName>
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    </protein>
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            <authorList>
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                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="5">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002722">
        <property type="protein sequence ID" value="CAE1291246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:calcium ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="CALM/Myosin/TropC-like"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
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            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
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        </source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
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    </evidence>
    <sequence length="244" mass="28128" checksum="5820C6947A2D2F27" modified="2021-09-29" version="1">MFQVNKLSKTEIAAYKEAFRMLDRDHDGRLTAKELGSVLRSLGQHAAESDLRDFINEVDIDGNGTLEVDEFLEMMSKRQWEVNHLEEIMDVFKVLDKNGDGFINAAELRHIMSKLGVKISDQEAQDMINEADEDGDGKLNNVEFAIYLSIYLSIYLSIYLSIYLSIYLSIYLSIYLSIYLSIYLSIYLSITVCSYLSIYLSIYLSIYLSIYLSQAVHIYLSIYLSIYLSIYLSIYLSTDYLNII</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D754</accession>
    <name>A0A812D754_ACAPH</name>
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        <recommendedName>
            <fullName evidence="2">Heme-copper oxidase subunit III family profile domain-containing protein</fullName>
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    </protein>
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    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
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                <person name="Bekaert M."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </dbReference>
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        <property type="entry name" value="Cyt_c_oxidase-like_su3"/>
    </dbReference>
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        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
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        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50253">
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    </dbReference>
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    </feature>
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            <end position="466"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
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        <source>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="562" mass="68037" checksum="4A5323855FCA903B" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D7W2</accession>
    <name>A0A812D7W2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MMAB</fullName>
            <ecNumber evidence="8">2.5.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SPHA_50296</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Farmed</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the Cob(I)alamin adenosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.17" evidence="8"/>
    <dbReference type="EMBL" id="CAHIKZ030002944">
        <property type="protein sequence ID" value="CAE1294280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D7W2"/>
    <dbReference type="OrthoDB" id="549173at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008817">
        <property type="term" value="F:corrinoid adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1200.10">
        <property type="entry name" value="Cobalamin adenosyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016030">
        <property type="entry name" value="CblAdoTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036451">
        <property type="entry name" value="CblAdoTrfase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029499">
        <property type="entry name" value="PduO-typ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12213">
        <property type="entry name" value="CORRINOID ADENOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12213:SF0">
        <property type="entry name" value="CORRINOID ADENOSYLTRANSFERASE MMAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01923">
        <property type="entry name" value="Cob_adeno_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89028">
        <property type="entry name" value="Cobalamin adenosyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="263"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="401"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="452"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="517"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="551"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="575"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="606"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="643"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="671"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="domain" description="Cobalamin adenosyltransferase-like" evidence="7">
        <location>
            <begin position="12"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAE1294280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="693" mass="80753" checksum="A89F94129EBAADCD" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DBT0</accession>
    <name>A0A812DBT0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_49452</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002833">
        <property type="protein sequence ID" value="CAE1292785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DBT0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1292785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="336" mass="39116" checksum="86E9A1DFAB87E1E7" modified="2021-09-29" version="1">MWGFRNIYYSFINPFLLYLQSASFFSASFSFFCLSFIYHPLVVISPFLLNLSFFFLFSVLLSSIFLDLPFQSVLSLFFSLSLSPFLLLVSLLSFNIYQFNAFLFFSLLLFRSVYLFIIGVTVHSLCMSIFFFSDSIFFIYQSLSEAPLACRCLFILPGFITLSQLTLSFYYFSLSLPLSLSLFLLTQSFVYVYFLHCCPYFVCLYISIFLYWIYLSFIYQSLSRLSILLLLLLPRYIATLSSHFSVSLPSSLIERGNILVLFLLSVRLSIFFSSIHSLSPVNLLQSLFFFPTLSFIYLHFFYRVFLPLSFPPPITISSVIPSFPSIFYLILTFHCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DCG4</accession>
    <name>A0A812DCG4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_50844</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003024">
        <property type="protein sequence ID" value="CAE1295304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DCG4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1295304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="152" mass="17244" checksum="8A3CA2D216F9AB9C" modified="2021-09-29" version="1">MSVYSSTESQNIRIYLSIAAYPHLSIYLSIYLSIYLSHSAHIYLSIYLSIYLSISLFISIYLSIYLSHSAHIYLSIYLSIYLSIYLILFISIYLSLFISIYLSISVCSHLSIYLSIEDCSYLSIYLSIYLSVCLSVSAIPLALSPPSFTQST</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DDI5</accession>
    <name>A0A812DDI5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">KRAB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SPHA_49858</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002892">
        <property type="protein sequence ID" value="CAE1293504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DDI5"/>
    <dbReference type="OrthoDB" id="3437960at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001158">
        <property type="entry name" value="zinc finger protein 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001289">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF29">
        <property type="entry name" value="MYONEURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="10"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="66"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="91"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="124"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="140"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="164"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="181"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAE1293504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="213" mass="22438" checksum="1456FEE7B27AE55A" modified="2021-09-29" version="1">MRTHTGEKPFQCEVCQKCFSQRGNLKIHRRRHTGERPFQCDICWKSFSQKGNLKTHVRNHAHKKSFCCDLCGKVFLHRSILKCHEKAHQVQRLSSLSPSNNSGGNGHPTSSPTSPALPLPIPPSSSSSPGSSTARSASTGTGGSSGVVGEKGAGFYSNTTSGYSGSGGPHSHGGGRSGPANPGPPTNQPPPHPNSNPNANNPNPNNPSNSVFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DDS2</accession>
    <name>A0A812DDS2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_51565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003131">
        <property type="protein sequence ID" value="CAE1296640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DDS2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1296640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="259" mass="30725" checksum="DFC70D9A9B9F6AAD" modified="2021-09-29" version="1">MPTRFLLLVILFIYLSIYLSLFSIYLSIYLSIYLSIYLSLFLFLSIYLSIYLSIYLSISFFLSFYLYLSIYLSIYLSQSISFFLSIYLSIYLSISVYFFLSFYLSIYLSIYLSIYLSQSISFYLSIYLSQYTLIFIAVILFIYLSIYLYIYLAIYLMNQSPLIFQLICCSIFLFISVCLSIYLSIYLSIYLSIYFSLFIICLSVCLSISFYFISIYLSIYLSIYLSIYLSICLSQPVLFSFLFHIKNIFVVYTRSYAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DFW3</accession>
    <name>A0A812DFW3_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Box C/D snoRNA protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Zinc finger HIT domain-containing protein 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SPHA_51542</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Farmed</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for box C/D snoRNAs accumulation involved in snoRNA processing, snoRNA transport to the nucleolus and ribosome biogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with FBL, SNU13, NOP58, NUFIP1, RUVBL1, RUVBL2 and TAF9. Interacts (via HIT-type zinc finger) with the RUVBL1/RUVBL2 complex in the presence of ADP.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the BCD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003125">
        <property type="protein sequence ID" value="CAE1296601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DFW3"/>
    <dbReference type="OrthoDB" id="272357at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070761">
        <property type="term" value="C:pre-snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048254">
        <property type="term" value="P:snoRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23023">
        <property type="entry name" value="zf-HIT_BCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.190:FF:000001">
        <property type="entry name" value="box C/D snoRNA protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051639">
        <property type="entry name" value="BCD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057721">
        <property type="entry name" value="BCD1_alpha/beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007529">
        <property type="entry name" value="Znf_HIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13483:SF3">
        <property type="entry name" value="BOX C_D SNORNA PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13483">
        <property type="entry name" value="BOX C_D SNORNA PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25790">
        <property type="entry name" value="BCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04438">
        <property type="entry name" value="zf-HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51083">
        <property type="entry name" value="ZF_HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HIT-type" evidence="14">
        <location>
            <begin position="23"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00068630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00077531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAE1296601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="311" mass="36038" checksum="D930266BBD80F251" modified="2021-09-29" version="1">MDAVQTQTEEISDNNNTLHKNLCEQCHVQPSKYTCPRCEIRTCSLGCVKSHKVDSGCDGIRDKTAYIPLEDFSDINLLSDYRLLEDVARVAEHGKRDILMKQHRKPPFLQYLTKAAYKRNIRFRTMPFPMYRRKKNNSIYYRKIDSILWDITWVFPHSAVLHTEKRTSEKLLVSEAFQNVLNPNTANAILLYKLKAYRTVDVKTLSFYMKQELRSKEKNKYYNLCAEESLEKNLSGKVVLEHPIIHVLFPEETSKYSLVSDTENLHSNNVPTSHSGEILQGSEMTKDKHIVPENEVTEAAPDELPIMKINN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DHR9</accession>
    <name>A0A812DHR9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RP-S7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SPHA_51985</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Farmed</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003198">
        <property type="protein sequence ID" value="CAE1297419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DHR9"/>
    <dbReference type="OrthoDB" id="10257314at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="entry name" value="Ribosomal protein S7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_uS7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_uS7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327">
        <property type="entry name" value="ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327:SF3">
        <property type="entry name" value="RNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="Ribosomal protein S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Small ribosomal subunit protein uS7" evidence="5">
        <location>
            <begin position="38"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAE1297419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="314" mass="36366" checksum="7136B01A68E46898" modified="2021-09-29" version="1">MWSPRYLNPTLSKEELAQELDEIDARKYQPIKAAQNNQTTSIFYNPTIVKFTNMIMKDGKKQVAVSIVDKMLANIKTVQILKYHSASDIEKAGIVLNPILIFFSFLFSPLFIFTPLIFALFLLFFLLIFILLYFRFYIYLRFLYFVTPVCDSLRKLPPDIASEVSDLLDNVTTENPFDVLKEAIIYRTAKSEERRINDLFNTLQLDQNKPTQLLRDEKPSETLIQSETLIQKLWLDKLPTHTVQILATLPEDLDLLRVAEIADRIVQARTHISSADSTPRDDTLKKMQQQIVKLSMQLERAFASNIQRIQISTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DI77</accession>
    <name>A0A812DI77_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 13">Ribulose-phosphate 3-epimerase</fullName>
            <ecNumber evidence="8 13">5.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">SPHA_54080</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Farmed</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>D-ribulose 5-phosphate = D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:13677"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="EC" id="5.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="15">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Carbohydrate degradation; pentose phosphate pathway; D-xylulose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 13">Belongs to the ribulose-phosphate 3-epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.1" evidence="8 13"/>
    <dbReference type="EMBL" id="CAHIKZ030003474">
        <property type="protein sequence ID" value="CAE1300809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DI77"/>
    <dbReference type="OrthoDB" id="1927044at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004750">
        <property type="term" value="F:D-ribulose-phosphate 3-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00429">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000074">
        <property type="entry name" value="Ribulose-phosphate 3-epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02227">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026019">
        <property type="entry name" value="Ribul_P_3_epim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000056">
        <property type="entry name" value="Ribul_P_3_epim-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004076">
        <property type="entry name" value="PRK05581.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01163">
        <property type="entry name" value="rpe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11749">
        <property type="entry name" value="RIBULOSE-5-PHOSPHATE-3-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00834">
        <property type="entry name" value="Ribul_P_3_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001461">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01085">
        <property type="entry name" value="RIBUL_P_3_EPIMER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01086">
        <property type="entry name" value="RIBUL_P_3_EPIMER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="15" id="KW-0170">Cobalt</keyword>
    <keyword evidence="12 13 17" id="KW-0413">Isomerase</keyword>
    <keyword evidence="15" id="KW-0464">Manganese</keyword>
    <keyword evidence="10 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="14">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="149"/>
            <end position="152"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="200"/>
            <end position="201"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00009541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00013188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00013920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR001461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAE1300809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="231" mass="25279" checksum="8F54EFA3BBEFF78A" modified="2021-09-29" version="1">MAASFGYTCKIGPSILNADLSALAEECQRMIDSGADYLHLDVMDGHFVPNLTFGHPVVKCLRPKVPNAFFDMHMMVANPERWIEGMADAGANQYTFHIEATDDPQGCVRKIKETGMKAGIGIKPNTSVETVLPYVDMVDLILIMTVEPGFGGQKFMENMMPKVRLLREKFRDLDIEVDGGVGTSTIQCCADAGANLIVSGSAVVGSDNPRQTISYMRMVVDEAIQKGQLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DK93</accession>
    <name>A0A812DK93_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_54462</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003537">
        <property type="protein sequence ID" value="CAE1301545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DK93"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="302"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="352"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1301545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="383" mass="45803" checksum="13020021D09B8133" modified="2021-09-29" version="1">MFLPFPKNDRLSFFSCHVHSLSFSISLLLLIRYLHTFFFFLFFIYMAIHSFLFLLFLSVFSFSSYFILNLFHFVLFIFLHVQISLSFSTLSSSSQSKFFLYFSFFFLYLFYRLSRKYLFSKSIVSSSFVLSFSSLFLFYLFSSFAFLFFFIFPSLFLTLSLALSLCFFLSLSPISLFFLSKKNETKWKTIYLIFFLTDFLFLFCLSFLLLCHFFLFLSSFNISFPLFFFLTYFLFLDVFSLSFSSLFLDLFSIPSLFYFSLLFILSRLFSFLPFLYLFIYALSFSFFIFYSSLLSFRFTSRLFSFVTLSFLLLLLLLLFQFSFLFLAFLFCLPFFLFSAVFSLFFPFPFPFLILFSFSLFLFLSLFSLLPSAILSIFLSFFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DMS1</accession>
    <name>A0A812DMS1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_57858</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003920">
        <property type="protein sequence ID" value="CAE1305452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DMS1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1305452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="290" mass="33672" checksum="FFDD8055117B6573" modified="2021-09-29" version="1">MSHLNGAFSRLSSFIIIGAWVGTRRGDNKIYLSIYLSMSIHYLYMSIRSLSLSLSLSLSIYLSISIYKCGRDSLGGAKKIMHFNMWCACRRQNSVIPTSLSIYLSIYLSIYLSISIHYLYMSIRYLSIYLSIYLSIYLSKSIHCLFTIYLSIYLSIYLSISIHYLYMSIRSRSIYLSIYLSIYLSIYLSIYLSIYPSLFTLYSLSIYLSIYLSIYLSIYLSKSIHGLFTIYLSIYLSIYLSLFTIYICLFTFDISIYLSIYSLSLSLSLYLSVCLSIYLYYSSNILSLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DQ01</accession>
    <name>A0A812DQ01_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_57005</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003813">
        <property type="protein sequence ID" value="CAE1304366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DQ01"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="247"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="287"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="322"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="381"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="411"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="436"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="473"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="535"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="543"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1304366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="601" mass="73199" checksum="630A8FA3FB6A1E4E" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DS86</accession>
    <name>A0A812DS86_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_61234</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004316">
        <property type="protein sequence ID" value="CAE1309551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DS86"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF4">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1309551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="357" mass="37092" checksum="A97E07F8B9C7E8EA" modified="2021-09-29" version="1">MYLSACVCVALSLSLRVSVSLSLSLRVSVSLSLSLCVCVCRSLSLFVCVCRSLSLCVCVCRSLSLCVCVCRSLSLCVCVSLSLSLRVCVSLSLSLRVCVSLSLCVCVCRSLSACVCVALSLRVCVSLSLWVGVCRSLSACVCVALSLSACVCVALSLRVCVALSLSACVCGALSLRVCVALSLCVCVCRSLSACVCVALSLRVCVSLSLCVCVCRSLSLRVCVALSLRVCVSLSLCACVCRSLSLSACVCVALSLSLCVCVCRSLSLSACVCVALSLSLRVCVSLSLSLSLRVCRFLSVSLTRSVCVCVCLSLDDSLSLDDSLSLDDSLSLDDSLSLDDSLSLDDSLSLSMTLSPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DSB9</accession>
    <name>A0A812DSB9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_58221</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003967">
        <property type="protein sequence ID" value="CAE1305869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DSB9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052505">
        <property type="entry name" value="Fungal_Heme-Binding_RBT5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35607:SF11">
        <property type="entry name" value="CELL WALL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35607">
        <property type="entry name" value="GPI-ANCHORED PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="151"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="291"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="330"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="367"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="401"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="425"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="459"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1305869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="531" mass="61215" checksum="7BED6CA9ED061A42" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DSU6</accession>
    <name>A0A812DSU6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_58523</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004007">
        <property type="protein sequence ID" value="CAE1306208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DSU6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1306208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="215" mass="24055" checksum="057E158A7E7DA1CD" modified="2021-09-29" version="1">MENNLYFIEFSNVDGMWFCEVFFHVYQLIIFFSSPFWLLTLSLFTPSLFIHLSSLYSPLLSLFTSPLFIHLSSLSLSLLSFSLPPLFLSPSSLSLSLLSFSLPPSLSLSLSSSLSLSLLFSFSPLLFLFLSSSLSLSFSPLLFLSLSLLFSFSPLLFLSLSLLFSFSLFLSSSLSLSFSLFLSSSLSLSFSLFLSLSLLFSFSLFLSLSLFFRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DUM1</accession>
    <name>A0A812DUM1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_61918</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004391">
        <property type="protein sequence ID" value="CAE1310158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DUM1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="332"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="362"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="470"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="510"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="537"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="573"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="657"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="683"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1310158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="704" mass="84564" checksum="195A0A1FA9AB7B67" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DXS1</accession>
    <name>A0A812DXS1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_64458</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004634">
        <property type="protein sequence ID" value="CAE1313274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DXS1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="330"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="358"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="391"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="423"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="454"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1313274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="472" mass="55273" checksum="5E321D08F8D90688" modified="2021-09-29" version="1">MSYSAQRHSFAEISNVFATNTTNEQHKCPESYSVENRVTFYTGLFFGIILFLSLSLSLSLSLCSILINALKHKSISSRDLSIYLSIYLSIYLSISLSLSLSINLSHSIHQFQRANSIVIYVSIYLSIYLSIYLSILFCSYLSIYLSIYLSIYLSICYLSIYLSIVCFYLSIYLSIYLSIYLSIYLILFISIYLSIYLSTYLSNSVHIYLSIYLSIYLSYSRKQIQNFYLSIYLSIYLSIYLSIYLSIYFNIGFSIFNSPVVIYLSIYLSIYLSIYLSNSVPFFLSFFLSFLYLSTNSLLRSIYLSIYLSIYLSIYVFVNICITECVPPNAHPPIYLSIYLSIYIFLKISSIKSNHSVYYLSIYLSIYLSIYLSIYLSIYLSIYLYSVHIYLSIYLSIYLSIYLFYLYHILFISYSKKKNKYKIIYLSIYLSIYLSIYLSIHIPNIHKKQIQNTLSIYLSIYLSIYLSIYLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DYZ3</accession>
    <name>A0A812DYZ3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_65085</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004686">
        <property type="protein sequence ID" value="CAE1314065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DYZ3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039715">
        <property type="entry name" value="ZCCHC10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13491">
        <property type="entry name" value="ZCCHC10 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13491:SF0">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032267183" evidence="2">
        <location>
            <begin position="43"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="296"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1314065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="327" mass="36338" checksum="C49D10FCC26FB54B" modified="2021-09-29" version="1">MIMPSIRSVSITVEHLAPKSDYDNLLLLLLLLLLFHPPSSFPHPPTPSFPLPSSLFSSSSSSSSSSSSSSSSSSSFLLPHPFPPPPTFFFSFSSSFFFFFFIIIIIIIILLFFFFLLLLLFLLLLLFLLLLLFLPPLQLPSLLPSFFSSSSSSSSSSSSPPPPFLPPPSSFLLPPHPFPPPPTFSFPTRPLSSSSSFSSSSSSSSCRFSSGCGFLSPFSFLYLPFGCELFILFSETPTFLISLSIVFSSNPILFLFVIKNSYFFLSPDPSGMSLHIYLSIYLSIYLSIYLPDSSYLSIYLSIYLSIYLSIYPYFAKLTLPCQSRYTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DZK5</accession>
    <name>A0A812DZK5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_63514</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004549">
        <property type="protein sequence ID" value="CAE1312253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DZK5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1312253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="249" mass="27890" checksum="335DEF7C56B86984" modified="2021-09-29" version="1">MSRRHAEDVESTALYYIRPAEDVEFTALKSRRNLRTLKPQLACPVDTLRALNPQLSHPVDTLRTLNPQLSHPVDPLRRLNPQLSIPVEKLKTLNPRLSRPVDTLRTLITQLSNLVDTPRTLNPQLLRAVDSTFSACLRNCGYIIRNEVTELESFGPQEVTGLERYRSIVLHSSKFLRAKALKFRNLIADYVATALNAPYTPLMTIRQQLSGSVGSLSSMLSHFSCPLHSLKIIVLQFSSAIASLGSIEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E096</accession>
    <name>A0A812E096_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase A2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SPHA_61817</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004391">
        <property type="protein sequence ID" value="CAE1310342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E096"/>
    <dbReference type="OrthoDB" id="6144264at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06094">
        <property type="entry name" value="RP_Saci_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000130">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon opus-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001995">
        <property type="entry name" value="Peptidase_A2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018061">
        <property type="entry name" value="Retropepsins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034132">
        <property type="entry name" value="RP_Saci-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327">
        <property type="entry name" value="ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327:SF3">
        <property type="entry name" value="RNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00077">
        <property type="entry name" value="RVP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50175">
        <property type="entry name" value="ASP_PROT_RETROV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A2" evidence="3">
        <location>
            <begin position="189"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="87"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="87"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="104"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAE1310342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="286" mass="32485" checksum="81086ADCBE8B669B" modified="2021-09-29" version="1">MSDTVLRKLWMDKLSPQTSQILVSLPDDLDLQRLAEIADKIYENKPPGNASATPLQPIVSSVRDSQELSKIKDCIAELTSQLQALQTAMHQQNRTPNNFTSRPRPSHHTSRRSRSTSRSRPIFNTCWYYFKYGQQARHCTKPCNFDINAAKDNKHSSRETTIPATSRDVCCRRDAKSRLFYIRDENSGYLFLVDTGAQISVIPAKPNMLNRKTDYTLQAANGSSIQTYGETSLTLNLGFRRSFPWVFTIAQVRTPILGADFLAHFNLFVNMSSLSLEDKTTNITRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E0M1</accession>
    <name>A0A812E0M1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_64085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004613">
        <property type="protein sequence ID" value="CAE1312926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E0M1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1312926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="279" mass="33631" checksum="F2E8134AF24BF8B8" modified="2021-09-29" version="1">MMIGSGFSSSGIFSVCVGEGIISPNILSFFFPQKETFSSLSLSLSLSRSLSFSLYFFLFSFLKIHYFFFLLFFSILSFFFSFFLKIYSFFFFLFSFCLFFFEKIHSFFFLSFFLSFFLFSFLLKNPLFLFLFLSFFLKIHSFFFPVILFFLSFFLSFFLSFFQLHSFFLSFNSILSFFLLFSSFFLSFFHSFFLSFFLSFFLSFFSLFNSILSLFLSFFISFFLSFFLFFSFFLFLSFFVISSFNFILSFFLSFFLFSFFLSFSCYSLLSFFLSFFLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E405</accession>
    <name>A0A812E405_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_66767</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004818">
        <property type="protein sequence ID" value="CAE1315936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E405"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="335"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="357"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="391"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1315936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="417" mass="48886" checksum="7620876AA9C7CF85" modified="2021-09-29" version="1">MSIIQGFKWYVKGKPFSFFLLAPSLYHPKREGNAPISVQISPSIYSETRHQSRFNLSIYLSIYLSTKVFDQYLSIFYLSIYLSIYKVYLSIYLSILSSKSVNLCSIYLSQSLFISIYYKAVHIYLSIYHIYPSIYLSIYLSLSIQVFNLSIYLSIYLSITKSVHIYLSITNPSTVPSIRSMIYLSIYLSIHLSIYLSITKSVHIYLSISIYLSQSIYIYLSISIIHPSQSIIKNLFISIYHLSIYPFIYLSHLSLYLSITKLFISIYLSIYLSIYLSIYPSIYPSIYHIQSLFISSIYLSIHLSIYLSQLIYLSPFISIYLFIYLIHLIYIDKEAVYIIYLNLSIIHLSITKPVHIYFIYLFIYLSIYLSSPVCSYFSIPIYLFIFSIKDIHVFVGFHIYLSIYLSIYLSIYLCEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E5G3</accession>
    <name>A0A812E5G3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_68166</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004949">
        <property type="protein sequence ID" value="CAE1317601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E5G3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1317601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="246" mass="28929" checksum="106B3EC18C800680" modified="2021-09-29" version="1">MLTLHYTFFPSFFLSFFFYLLSFFLSFFLSFIFLFLSFVLFFLNPISTSTNISFLLSLILTSPINAFYLSIYLSIYLSIYLSIYLSIYLILIYRSVYSVRIHLSIYLSIYLSISSLHLSIYLSIYLSQSLHIYLSIYLSIYLSIYLSIYPSVYIIVLIYLSIFKSIYLSIYLSIYLSIYLSNIFKSIYLSIYLSIYLSVCLSVYSNKLICLLSIYIHIYPSLLIYLSLSVNLSIYLSIYLSIYLSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E5W3</accession>
    <name>A0A812E5W3_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_68983</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005042">
        <property type="protein sequence ID" value="CAE1318541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E5W3"/>
    <dbReference type="OrthoDB" id="10030815at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1318541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="180" mass="19436" checksum="4D282C2E9025A48B" modified="2021-09-29" version="1">MTHHVACWNALTLKLEETQALTVHALHQYKVDVACLSEVKLADHGHKSIKVPLSDAAYHLYYSGPTDGSGRHGVALVLSDQANNALLAWELVSPCLARVHLRGALFNISIIAVYTPTLDADEVTKASFYDRLQAVMDGISPRDFVVIAGDFNARTGTVTPITDILSDHSLSVTAARTESG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E6X5</accession>
    <name>A0A812E6X5_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Molybdenum cofactor biosynthesis protein 1</fullName>
            <ecNumber evidence="6">4.1.99.22</ecNumber>
            <ecNumber evidence="7">4.6.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">SPHA_67599</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">Farmed</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Isoform MOCS1A and isoform MOCS1B probably form a complex that catalyzes the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP). MOCS1A catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate and MOCS1B catalyzes the subsequent conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cPMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic pyranopterin phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:49580"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:59648"/>
            <dbReference type="ChEBI" id="CHEBI:131766"/>
            <dbReference type="EC" id="4.6.1.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>GTP + AH2 + S-adenosyl-L-methionine = (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine + L-methionine + A + H(+)</text>
            <dbReference type="Rhea" id="RHEA:49576"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:131766"/>
            <dbReference type="EC" id="4.1.99.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="20">Isoform MOCS1A and isoform MOCS1B probably form a heterooligomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the MoaC family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the radical SAM superfamily. MoaA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.22" evidence="6"/>
    <dbReference type="EC" id="4.6.1.17" evidence="7"/>
    <dbReference type="EMBL" id="CAHIKZ030004896">
        <property type="protein sequence ID" value="CAE1316846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E6X5"/>
    <dbReference type="OrthoDB" id="429626at2759"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061799">
        <property type="term" value="F:cyclic pyranopterin monophosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061798">
        <property type="term" value="F:GTP 3',8'-cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21117">
        <property type="entry name" value="Twitch_MoaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000117">
        <property type="entry name" value="molybdenum cofactor biosynthesis protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01225_B">
        <property type="entry name" value="MoaA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013483">
        <property type="entry name" value="MoaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040064">
        <property type="entry name" value="MoaA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000385">
        <property type="entry name" value="MoaA_NifB_PqqE_Fe-S-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010505">
        <property type="entry name" value="MoaA_twitch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050105">
        <property type="entry name" value="MoCo_biosynth_MoaA/MoaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02666">
        <property type="entry name" value="moaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001199">
        <property type="entry name" value="PRK00164.2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22960:SF0">
        <property type="entry name" value="MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22960">
        <property type="entry name" value="MOLYBDOPTERIN COFACTOR SYNTHESIS PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06463">
        <property type="entry name" value="Mob_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01383">
        <property type="entry name" value="cyclic_pyranopterin_phosphate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01386">
        <property type="entry name" value="main_SPASM_domain-containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01067">
        <property type="entry name" value="SPASM/twitch_domain_containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01305">
        <property type="entry name" value="MOAA_NIFB_PQQE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="15" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="13" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="17 23" id="KW-0456">Lyase</keyword>
    <keyword evidence="21" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="21" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="394"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="427"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="22">
        <location>
            <begin position="89"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00015273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00054222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00063038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="CAE1316846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="488" mass="56587" checksum="4F1880832A646E9E" modified="2021-09-29" version="1">MVFWGCWRPGRKFVLSHFSRKTVSNNLRTNKWNRNEIFNCTNPKNSSSSSTSYASSTITVTNQVNHLKPSKKYFENVDVLPFSAFLTDKYGRHHSYLRISLTEKCNLRCQYCMPEDGVKLTPAEHLLTTKEIITLSSMFVKNGIKKIRLTGGEPLIRRDLPHIVREMDHLKAEGLETIAMTTNGVTLYRVVSELKKAGLDLINISLDTLVPQKYTFISRRNGLDKVMKSIQKCLEVGFRPLKINCVVMKNLNDDEICDFVQLTQNMDLDVRFIEFMPFDENRWNYDKMVSYKEMMKTITAKWPDIQKLEDGLSDTSKAFKVPGFQGQIGFITSMTDHFCGTCNRLRITANGNLKVCLFGNEELSLKDLLRSNLPEEEILEKIEIAVKGKRKQHAVSFFISLFFVSYSFLLIFYPLSSSLFIPFSFLFIFPLFCLFFLSFSFSFLSFFIHCFSFLLSPQYSQHEKPSNDLDWWMKKLEKTTAFIIQYGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E719</accession>
    <name>A0A812E719_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_67309</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004876">
        <property type="protein sequence ID" value="CAE1316641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E719"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1316641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="208" mass="24171" checksum="E4E7C5241D5C540A" modified="2021-09-29" version="1">MSVRMHGSCFVSVCVFCYLSSVYCISMTIMTLIIYLSIYLSIYLSLLISITVSLSIFISLSDYNLSIYLSIYLSIYLSIYLSISDYSLSLSLYLNISLRLQSIYLSIYLSIYFSSHDTPLSPWFESLPNYSFTQVKHFKNCFKYLSIYLSIYLSIYLNMFFLSIYLSIYLSIYLSILIYSISINTLPHFTSLAIPIFVFVCFICFHLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EAY1</accession>
    <name>A0A812EAY1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_70325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005144">
        <property type="protein sequence ID" value="CAE1320027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EAY1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1320027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="196" mass="23466" checksum="35FA593A54180485" modified="2021-09-29" version="1">MHVSKADLFSLFLLKLPLYISCYLSIYLSIYLSIYILFYYKQECRFYLSIYLSIYLSIYLSIYPGREHYEIDLSIYLSIYHFQSIQFLSISFCPYLSIYLSIYLSIYYIQSLQFLTISFCPYLSIYLSIYLLANTAYKGRRNKINLSIPFCSYLSIYLSIYLSIYLSNSFHYLSIYLSISFFHYLSIYLSFMGSYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ED52</accession>
    <name>A0A812ED52_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="13">CTSD</fullName>
            <ecNumber evidence="13">3.4.23.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SPHA_70887</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Farmed</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.5" evidence="13"/>
    <dbReference type="EMBL" id="CAHIKZ030005192">
        <property type="protein sequence ID" value="CAE1320666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ED52"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000009">
        <property type="entry name" value="Aspartic proteinase A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000002">
        <property type="entry name" value="Vacuolar aspartic proteinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="6 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 10 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 10" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032613983" evidence="11">
        <location>
            <begin position="21"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="12">
        <location>
            <begin position="72"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="103"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAE1320666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="392" mass="42756" checksum="4C8D2E94760C0718" modified="2021-09-29" version="1">MKAALLITLAIWCFVAHCEALQRIQLHKMTSVRKNLLESGSSNITRKMVVELQQKYKGPTPEPLSNYLDAQYYGVISIGTPPQKFKVVFDTGSSNLWVPSKKCEIKDIACLLHNKYNSDKSSTYKANGTEFHIQYGSGSLDGFLSTDVVAIGSAVVKGQTFAEATNQPGLVFVAAKFDGILGMGYDTISVDKVKPVFYSMISQKVVDKSVFSFYLNRDPNGKEGGELILGGSDPKHYSGNFTYVAVTRKGYWQFKMDKVSVGSLVLCQNGCQAIADTGTSLIAGPTKEIKMLNEAIGAHLIPGGEYIVDCNDIPKMPNVDFMLGGKTFTLKPSDYVLTVNSMNKTVCMSGFMGIDIPEPAGPLWILGDVFLGPNYTEFDLGNNRVGFATTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EDS4</accession>
    <name>A0A812EDS4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_70756</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005175">
        <property type="protein sequence ID" value="CAE1320483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EDS4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1320483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="350" mass="39849" checksum="75941D76AF081190" modified="2021-09-29" version="1">MTGRAYTASGSHRYRYLSIYLSIYLSVYLAICLSIYLSICMICRSEIRQGRIRRRGRRERMDGYRHRNKGFHRLAQNYIQQHSFNRTFKSFIKTTGMNSVKGTFTKYQGQTKPTGSIESIGHFVWAQPESGDVLPDDDKERNFIQSDKTGVQDRQHYSGRVDDQGQRGGVRSESAAVLRALQIQAGYPTAWDGGLDVATGPKFGTLDDESNWMHEKNRKRMRADNQDIAMLEHRQKLIQMRIGFLLRTKQDSNKQDTVHVKGQSRDGADTRTTTQQPIGDSLLYFRVDLHVGGGWFHESLQHPQKVPVTNKVCSEAAVGPDITLRPTADRPDQQATLRPDTEGIGPRKDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EGP2</accession>
    <name>A0A812EGP2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_72802</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005344">
        <property type="protein sequence ID" value="CAE1322850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EGP2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1322850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="197" mass="23218" checksum="18BEBC733FEC9DFD" modified="2021-09-29" version="1">MFISIYLSIYLSIYLSIYLGCSYIFNNVRLFKSVHLHSLFISIYLSLYLSIYLSIYSSVHIYLYQSFHIYLSIHLSIYSSCSYLSIYLSIYLSIYSSVYIYLSIYLSIYLFFCSYLSISIFSYLSVYPSVYLIFLFISIYLSSYLLFCSYLSIYLSIYSSVRIYLSIYLSIYLSIYLSQSVHIYLSFCSAVAAYTEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EI97</accession>
    <name>A0A812EI97_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_74169</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005408">
        <property type="protein sequence ID" value="CAE1324374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EI97"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1324374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="352" mass="40947" checksum="EF09ECF7BC7E1F87" modified="2021-09-29" version="1">MSFVTIDCYVVKWVRLDGESFANAGGDNPFPRFNFSLSIYNSVHLSQSAHIYLFISTFSYLSISLYLSIYLSIYLSISVYIYLSIYLYLSISLYLSIYIYLSVYLSVYTYLFIPIYLFNFIPIYLSIYLSICLFNFISIYLSIYLSISLYLSIYVYLLFISISLSIYLAIYLSVHIYQFISVYLYLSIFPHLSVYTYLFTSICFCLSIYLFTSISLSIYNISLCLSINLSNCLSIYLSIYLSLSISVHIYLIYLSIILFISPAVAFVCLSIYLSIYLSIYHDALPILFLYNNNHRRTVFFSNIKTNGIYCSTTRKTDSPDEYKRIHEKSEKCLRACCKTSTKSIVNLMIEIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EIB7</accession>
    <name>A0A812EIB7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_71710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005255">
        <property type="protein sequence ID" value="CAE1321661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EIB7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1321661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="232" mass="26703" checksum="EEFC8EF7FA0B692A" modified="2021-09-29" version="1">MGPNILYFISQPASLIRKGSASKSRSHIPIFAFSPSSCDLETHLNHLSIYLSIYLSIYLSIYLSICSNLSLSLSIYLSIYLSIYLSIYLSIYVQISPFCLSIYLSIYLHHYIITKSIYLSIYLSIYLSIYLSMYVNAFRSFYLSIYFSIYICSNLSIYLSIYLSIYLSIYLSMFKSLPFIYLSIYLSIYLCLLTSIYLCSLISIYLSIYLSIYLSIYLSNNNIADATGNLPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EJM2</accession>
    <name>A0A812EJM2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_73739</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005388">
        <property type="protein sequence ID" value="CAE1323910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EJM2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1323910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="263" mass="31718" checksum="EB91226E3FD88F09" modified="2021-09-29" version="1">MTSFLFSSNSSVFRFLFVLHVSFFIFLDKRKRHLNSMKYLSLLYGFFPFSIPAIYYHSASFFLSFFLSFFLSFFLSYSYIFHIFSDFDLSVHHFFKLTFYFLSFFRSFVLSFFSQHSVYLSFLRLSSFASKSLTFLSYFRNHSLPLPVFFEYLSFFPNHLSLPRFMPLSLPSLYQTALIFHFFLSELIIHKNLSNNQNFVSTCRLFLPHYLAFFFPDVINSLYIFFHSFILSFFLSFFLSFFLSFFLNKLAANHFACFIRFYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EM33</accession>
    <name>A0A812EM33_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_75662</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005468">
        <property type="protein sequence ID" value="CAE1326092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EM33"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1326092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="187" mass="21697" checksum="9F47B648F9A2C832" modified="2021-09-29" version="1">MRPEIFSLSLYTCFLFSLLHYIPLSFCRHDTLISPFIYVYLSLVSLVFIESHHSFSLSLSLSVSLSPSILFSSSFRSLSLNNYLAFSLHHTRSHTIYVSIYLSFFLCLSVCMSVSPPLSFSLSLSQLFFSNNSSDHITLSLFSFFFSFLSFFFLSFFFLFFLSFFFLSFFFLSFFFLSLLRVNATCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ENI9</accession>
    <name>A0A812ENI9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_75848</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005475">
        <property type="protein sequence ID" value="CAE1326306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ENI9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="341"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="392"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="425"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="494"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="551"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="579"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="611"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1326306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="650" mass="76569" checksum="6554C77CE84DBC00" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ENT1</accession>
    <name>A0A812ENT1_ACAPH</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_76603</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005494">
        <property type="protein sequence ID" value="CAE1327076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ENT1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="6"/>
            <end position="33"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="297"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="388"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="419"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="447"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="480"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="505"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="532"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="560"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1327076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="759" mass="82282" checksum="C5A43DE3A480BBAF" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EPV0</accession>
    <name>A0A812EPV0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_76439</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005489">
        <property type="protein sequence ID" value="CAE1326876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EPV0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
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        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1326876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="273" mass="32800" checksum="E2490B33E861A058" modified="2021-09-29" version="1">MVITTTNKNFNSSFLLCLFVSFFLLLLLLLLFFFFFFFFFFFFFFFSSSSSSSSSFLCPVFLEDMGERHDQCWSHICFLISIFLPLLFSIYLSIYLSIYLSIYLSICRCLFISIYLSIRTFPSIFFFRSFFSFTIYLSIYLSIYVSLSLFIFLFLSFFLYLYLFFISFSLFIYISSYLSIYLSIYFSLFLSFFLNLSIYLSIYLSIYFIFLSLFLTLYLFLLISFYLFLIRPIYLSIYLSIYLSMLVSSFLPSFLPFFLSFNLSISLIFFVVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EQQ5</accession>
    <name>A0A812EQQ5_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_80540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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            <taxon>Metazoa</taxon>
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            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005601">
        <property type="protein sequence ID" value="CAE1331356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EQQ5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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            <begin position="64"/>
            <end position="83"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1331356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="285" mass="31955" checksum="110D6363D7D8B7CC" modified="2021-09-29" version="1">MLSENGSALSSPFSNSLNLFPATQTRRGVFALKQQGFLPIHFKANAGKRLAAFRCRRKQSSKRFIAAPCILIAGITVSLLFNLQRFHVLVQISPTRRTSARQQLKTPNTVNVTHAEQATAEEHIITPVTDDHIASTSNSALHSSAYRDDDQPDSSAKAAKTPRRGNLSRRSKKASPAKRKREQDSIECASLGEKRLASTSNTDLHSSECRGDDRPGSVSKRAKIPWRGNLNRRSKRTSAAKRKREEETEVEVHLRLSSQSQRRQYILSHETLGERNNRLYCKSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ESY1</accession>
    <name>A0A812ESY1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_76850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005498">
        <property type="protein sequence ID" value="CAE1327398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ESY1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="297"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1327398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="313" mass="37921" checksum="51C16E1857B15125" modified="2021-09-29" version="1">MTIILQKLQRNVFVIIYATSTAAFQLCLTILFFKLFHFSFFLSFFLSFFLSSVFHFISSSVSLLLFHSFFLSFFLSFSIKAFSFFLSFFLHHFSFLCILLRFYLILLIFLSFFLSFFLSSLHLFLSFLVHSCFFFLSFFFFIFSFSVFIAPLSFFPSLLSFFLSFFLSFFLSSLFFFFFFLHRFHICFLFLSVFFIIVFLFSVSFIFVLFYCFFFLSVFLSFFLSFFLSFLVHKIYIYYKFLSLSFLSFFLSFFLSFFLSFSFFLSFLVAIYSFFLSFFILTFIHSFFLFSSFLPDFYHSLFFLSFFLSFFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EUP1</accession>
    <name>A0A812EUP1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_77424</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005517">
        <property type="protein sequence ID" value="CAE1327945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EUP1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="282"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1327945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="310" mass="37069" checksum="895E6D59C867FFF1" modified="2021-09-29" version="1">MPSGLQYKHQYWKKADDFKIIHLFITRFFFLSFFLAFLLAFFLFSFFLSFFFLSFLLPFFLSFLLSFFLSFLLSFFLACFLACFLSCFFFFLASLLSFFFFLSFFLSFLFVCFLSCFLSFFLFFFLSCCLSFLLAFFLAFFLASLLSFLLPCFVSFFLSFFFSFLLSFLFAFFLASLLAFFLSFFSFFLAFLLACFLFFSFFLSFFLYFFLSCLLAFFIAFFLACFLSCFLTCFLSFFLAVFLACLLSFLLSFFFFYLSCFLACFLFSFFFLSFFLACLLAFFFLFSFFLSFLLACFLSFFLSSFYVRVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EW62</accession>
    <name>A0A812EW62_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="18">CPA2</fullName>
            <ecNumber evidence="18">3.4.17.15</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">SPHA_80546</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">Farmed</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Involved in the digestion of the blood meal.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the peptidase M14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.17.15" evidence="18"/>
    <dbReference type="EMBL" id="CAHIKZ030005601">
        <property type="protein sequence ID" value="CAE1331354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EW62"/>
    <dbReference type="OrthoDB" id="3626597at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03860">
        <property type="entry name" value="M14_CP_A-B_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000040">
        <property type="entry name" value="zinc carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.340">
        <property type="entry name" value="Metallocarboxypeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036990">
        <property type="entry name" value="M14A-like_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003146">
        <property type="entry name" value="M14A_act_pep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705:SF140">
        <property type="entry name" value="FI02848P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705">
        <property type="entry name" value="PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02244">
        <property type="entry name" value="Propep_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 18" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 16" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032627453" evidence="16">
        <location>
            <begin position="21"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="17">
        <location>
            <begin position="133"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="433"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="14">
        <location>
            <position position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00057299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CAE1331354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="453" mass="52794" checksum="7E22F99896105E99" modified="2021-09-29" version="1">MRKVIFSLCFLFLSFSFCTADQSIEGHPTTGRNVSYYGHQVLEIYPNTLSKVQHFLNFGRKENLDIWKHAAHANDSIHVLLSPEKLRLMKIELEKMKTQFNVLIPDVEQLMHTERDNTHHRHKRSSNHFNLYSYQSTKQIYAFLDSVCSESKALCNIFSIGRSSEGRDIKMLRLSAPKKRYQKLIILIDAGMHGREWISISVILYFIYELAINPTNKRVNKMLLNYFDWFFVPILNPDGYEYTRNYDRLWRKTRSRSSNYYNCIGVDINRNFPNHWNEIGSSEDPCSVEYAGVTALSEPESMALANVMRMNEGDIVAYISLHAYGQLWMYPWGYTLKPPNDLTDLFRLASRATNAIRHYSKREYAVGPSSHILYIASGASDDYAKADRHIKYAYTVELPDDGLYGFLLPSRLIPKTSEETFVGLKAFTKGLAKKTRRERNKRAKRQKRRLRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ANF5</accession>
    <name>A0A812ANF5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_2508</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000069">
        <property type="protein sequence ID" value="CAE1148547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ANF5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1148547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="207" mass="24017" checksum="784219194A3150A3" modified="2021-09-29" version="1">MLFSSSFPPFHLEFSFLGAAHFVPHPFGFKHVASVTTPLSVVHGYYKRIEKDLNLSIYLSIYLSIYLSIYLSVRQCQPVSIYLSIYLSIYLSIYLSVRQCQPVSIYLSIYLSIIQSQSVSIYLSIYLSIYLSIYLSYSLSLFLSIYLSIYLSIYLSIYLSVRQSQPASIYLSIYLSIYLSIYLFYSYSYCVYVHACVDSDYFIINPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AP19</accession>
    <name>A0A812AP19_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_2955</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000086">
        <property type="protein sequence ID" value="CAE1150592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AP19"/>
    <dbReference type="OrthoDB" id="6162664at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033058183" evidence="2">
        <location>
            <begin position="22"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="293"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="316"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1150592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="510" mass="55478" checksum="2F75B2C7C4D10992" modified="2021-09-29" version="1">MSTFLIYLFSLSLSTFFFSLCLNSTMNGAWPFMSCIHIQDNVLNMWHRIQGQFRHIQIKDDDSSNLKHSIVQTLVSPPGPLPSTSSRTPASPARGSFSRKYSLIKEESVEEEGSCEEVEFKSVRSAENLMDSNKRASSVEHMFSLDTSAVRRPLHSVASSPQLLNQISEERESDEEEDIPLTMLPTSLSSSASSKVASRNIYGCRANMASPEVLHKYEQHKKRRGTGQRGTSCSSSDASDTDDTDSIARKDKLKHKFATRRDSSDHSSDNDGPGGIGGMSGGPRPLGQGGTTGSNRQNNKPNNSNQQDKSSDNKGNRGSSGKSSKGNDPNSESCNHDCDSNGDSNIGGGNQPQAVLANSNSGCSSRLSGISINSCEMKNSNSLVSSNNSFSKLCIEDNLCSEQQDCKRVKQGPPNDLDVNYLNELNAQIWEVKSRANNDCKETSKAPLPEDVLSICSADCSLHIRKGKRFGRRIKTDINRNGLKPGFCKMAGSSKSSNSVKVETKCCSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AP92</accession>
    <name>A0A812AP92_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_4160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000129">
        <property type="protein sequence ID" value="CAE1154325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AP92"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1154325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="160" mass="19576" checksum="57C5F17324D7BB8B" modified="2021-09-29" version="1">MVDRSISGRGRFRVLLFLPIFFLSYIRVFFLFSFFLSFFLSFFLSFFFRILVFFSFSFFFLGFAFSFFPFLSFFLSFFFFLSFFLSFAFSFSFHFLSFIVFGSSFLFLFFLSFFLFLSFFLSFFLSCSFFFPFSFFHSLIRSLSFLFLLSFFFSFFILSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812APE3</accession>
    <name>A0A812APE3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_2236</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000062">
        <property type="protein sequence ID" value="CAE1147814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812APE3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="291"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="373"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1147814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="404" mass="47655" checksum="4D81C7224F7C2BC2" modified="2021-09-29" version="1">MATSIPSTKYLIHLSIYQNQFCFYEYLIYLSINSFYSKYHLSIYLSISPNILSPTLSYVIHENIIYRGFVKTWSIYPLSNYSYIKILINIYLSIYLYHLSIYLSLFFIYRQSMSFSAWILTKSPSTCPTRHESPSCSQRPISHRLFPQFGRPMGAPRDSSLLANIAIFSPNRCTQLSILLSISFQSPLYLSIYLSIYLSIYLSIYLSIYLNLFPIHLSHSIPIYLSIYLSIYLSIYLSIYLSIYLTLFPSISISLYSHIYLSISSIPIYLSIYLIYSYLSIYLSSIYLSIYLSIYLSIYLSIYLTLFLSIYLSISLYSYLSIYLSHSIPIYLTLFLSIYLSHSLYSYLSIYLSIYLSIYLSILVPYYQMFTPIFVPFFFLVLFLLFFLHFFLPFFLVCQFFYFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812APW1</accession>
    <name>A0A812APW1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_4460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000141">
        <property type="protein sequence ID" value="CAE1155409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812APW1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="308"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="339"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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    </feature>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        </location>
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        <location>
            <begin position="530"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="554"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="582"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="610"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="640"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1155409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="689" mass="81599" checksum="81694344D9F184FF" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AS42</accession>
    <name>A0A812AS42_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_3238</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000095">
        <property type="protein sequence ID" value="CAE1151841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AS42"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="332"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1151841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="355" mass="41918" checksum="090AC361EAE78B59" modified="2021-09-29" version="1">MNWPPSHLANSDINYLFLLSISAPDSETIGRRPSISIYLSIYLSIYIIKTFIYLSIYLSIYLSIYLSITVFSYLFCLYLSIYLSIYLSIYHCSLSIYLCSLSISLSLFIICLSFSLCSYLSLFIIYLSIYLTISFCSLSMFVIYLSMHVYYLSIIVHCLSMLIIYLSIYLSIIVHHLSMLIIYLSIYLSIIVHYLSMLIIYLFIYLSIYLSIIVHYLSMLIIYLSIYLSIYLSIYLSLFIIYLCSLSIYHCSLSIYAHYLSIYLSIIIIVHYLSMLIIYLSIIVDYLSIYFFIMFISIIVRYLSFLSIYVYHSVLSIYLSIYLSLFVHYVSYLYSFFFSFFLSFFLSFFLSFFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AST3</accession>
    <name>A0A812AST3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_4778</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000155">
        <property type="protein sequence ID" value="CAE1156434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AST3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="315"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1156434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="353" mass="39598" checksum="A60C8B3E8E7443EB" modified="2021-09-29" version="1">MPLFFSLLSFFPLLFIFSLSLFLHFYTLFFLPAYSLFYISFQLASSTCFCAFFPPVLCMLSLPNPLFCVCSLFPPPFCLCSLFHPPFCLCSLFPTPFCLCSLPPFCLCSLPPFCLCSLPPHSVYARSSPHSVYARSSPPILSMLSLPPPVCLCSLFPPVLSMLSLPPRSVYALSLPPVLSYALSSPPFCLCSLFLLLLSYLHPSTSCFAFSFHFFCHISFSFILFFPCLPPPSHFHIFLVFFLPLFHTLFSMPASLSLHFILSLPSLLPSPSLFSYLPLFPLFIHPLLVFSPFAFYTIIISCLCTSNFSFFHTYLFSISLFSSLLGSSSLTFILSSTVASFSFLFRLSLPLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AT38</accession>
    <name>A0A812AT38_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_3752</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000113">
        <property type="protein sequence ID" value="CAE1153178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AT38"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1153178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="225" mass="26531" checksum="A4BD0A9F9639BE3D" modified="2021-09-29" version="1">MGKMAKPICKTPSPKSESVCYTRIYLSIYLSIYLSQAFNYLSIYLSIYLSQAFNYLSIYLSIYLSIYLSQALHYLSIYLSIYLSLFTIYPSIYHRRFIIYLSIYLSIYLSQAFIYLSIYLSIYLSQSLYYLSIYLSIYLSISDLLLSIYLSIYLSIYLSITGAPLSIYLSIYLSIYLSIYPSLFTIYLSTYLQKVVRHKKFLFDICESLLKTVQDEIELKILRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AVB2</accession>
    <name>A0A812AVB2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_4875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000159">
        <property type="protein sequence ID" value="CAE1156665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AVB2"/>
    <dbReference type="OrthoDB" id="7468475at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1156665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="240" mass="27224" checksum="91D06DD7CDBBF5BE" modified="2021-09-29" version="1">MRPTTLQLRDQQTHIEGIMSPTILQLRDQQPHIEGYMSPTTLQLRDQQSHIEGSTSPTTLQLRDQQHHIDGNMSLTIFQLPDQQSHIEGSMSPTTLQLRDQQPHIEGSVTPTTLQLRDQQPHIEGSMSNHIRDQQPHIEGSMSPTTLQLRDQQPHIEGSMSLTILQLRDQQHIEGSMSQPYCNYVTNNLHIEGCMSPTILQLRDQQPHIEGSMSPTILQLRDQQPHIEGSMSPNHIATTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AVC7</accession>
    <name>A0A812AVC7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_6205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000203">
        <property type="protein sequence ID" value="CAE1160017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AVC7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1160017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="150" mass="17710" checksum="297CC4BC9026D179" modified="2021-09-29" version="1">MSVHIYLSIYLSMYLSLLITYLSICLSISICSYLSIYLSIHIYLSQSIHMYLSQSTHIYLSIYLNLYTSIYLSISIYSYLSQSIHMYLSQSIHIYLSIYLSICLLIYLCFRLKCYFEATKVVMIYKVLSKSPQQKPIFLLNLSHLHCRPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AVV6</accession>
    <name>A0A812AVV6_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Vacuolar-sorting protein SNF8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SPHA_6206</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Farmed</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the endosomal sorting complex required for transport II (ESCRT-II).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the SNF8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000203">
        <property type="protein sequence ID" value="CAE1159980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AVV6"/>
    <dbReference type="OrthoDB" id="283883at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000814">
        <property type="term" value="C:ESCRT II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000085">
        <property type="entry name" value="Vacuolar-sorting protein SNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000397">
        <property type="entry name" value="Vacuolar-sorting protein SNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016689">
        <property type="entry name" value="ESCRT-2_cplx_Snf8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040608">
        <property type="entry name" value="Snf8/Vps36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12806">
        <property type="entry name" value="EAP30 SUBUNIT OF ELL COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12806:SF0">
        <property type="entry name" value="VACUOLAR-SORTING PROTEIN SNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04157">
        <property type="entry name" value="EAP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017215">
        <property type="entry name" value="ESCRT2_Vps22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0967">Endosome</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR017215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAE1159980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="250" mass="28444" checksum="272AF2FEC0C3E407" modified="2021-09-29" version="1">MTFMYPLPVSVSLSLLCMPPHRPATKIKGNVIAEDQLAQMAKQMETFKVNLEEFATKHKDQIKKDPEFRVQFQEMCASIGVDPLASSKGFWSEMLGVGDFYYELAVKIVEVCMATSHRNGGLIRLDELKSRLEVSRHKNTQEISIDDLLRAIRKLKTLGNGFTIHPIGKTFLIQSVPGELTMDHTTVLQQAQKSYYVTVSGLVDTLKWEKERAIKALEYMLKEGLAWVDDQAEGERQYWFPTLFPDAQTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AVX8</accession>
    <name>A0A812AVX8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_6062</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000200">
        <property type="protein sequence ID" value="CAE1159645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AVX8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1159645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="262" mass="31682" checksum="F3BB786322DA9139" modified="2021-09-29" version="1">MFFLFSLFSHSLLFISIYDAFFYFLSFQMTFSFFLSFFLSFFSSKHLKSYQLSIMFFLSFFLSFFLSFSFIFHAAIFHFFYFYFSLLSYFASIIFFLSFFLSFFLSFKMHFLSFFFSFNITYPSFLPFFSFSRSLPVQNPPEVILSTNFISFFSLLYSYQSLLISIYLSIYLSIYLSIYLSIYQSFAHIYLSKTAHIYLFVSLSLLISTHLPQFIYLLIYISLFISIYLSIYLSIYLSIYLFIYLSIYLSHSHFDHKCWVRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AWL7</accession>
    <name>A0A812AWL7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_5720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000188">
        <property type="protein sequence ID" value="CAE1158852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AWL7"/>
    <dbReference type="OrthoDB" id="10064731at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042756">
        <property type="entry name" value="Sel-1L3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44444:SF6">
        <property type="entry name" value="LAMININ G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44444">
        <property type="entry name" value="PROTEIN SEL-1 HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="330"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1158852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="347" mass="40719" checksum="5F9D6FDA46D100ED" modified="2021-09-29" version="1">MDFKYNFRPFIYITVIFLRFSLIPGKRPEEISVVLNDAYFTDKQDYIKVLNVPPKLTKSMVLVTEYKCHEESMVGLQIIVDTSAHIQKTIFRDNWNCIPEKKLKTHNTVVILPDYFVYRPDIFNPHSKLIANVKLRGWLHDMKHWPSYLSLDMEYEESQVRVSYNIATDPPYSRLPKPANGCAVWYYDVLSNRSVKRIPKCPAEAVRAYHKIPVAEEDIAKTTVTTPFGLFVFVRFPFGLRNAAHVFVSIYLSIYHLSIYLSIYLLNTIYLSIYLSIYLSLSIYLSVRIYLSSIYLFIYLSIKYDLSIYLSIYLSIYLLNKSIYLLNKSIYLSIYLSIYLSIYLSIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AWP3</accession>
    <name>A0A812AWP3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_5173</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000172">
        <property type="protein sequence ID" value="CAE1157360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AWP3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1157360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="223" mass="24668" checksum="F3C0B34ECA9CEFA7" modified="2021-09-29" version="1">MLSIVKYRLPPPQSTFFFFFSVATELFLSITAPTKYLFLSLSPSLSISIYPSLNLSYLLSLSLSLTYKHSSSFSHPCFSISRTFMILSLTFVCFSPSLSLSLSLLHTHTSVFLSLSHPSLFSYSHPFPFSISLYHPLFVLLLSFGLSLCFSLSLHTVTFLKGVAYLIGNWCIECLLVSRLRHCSHPLHPPSLSLSLPLSLPPSLSLSLSLPSLSLSPSLPLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AZ62</accession>
    <name>A0A812AZ62_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">GDP-D-mannose dehydratase</fullName>
            <ecNumber evidence="5">4.2.1.47</ecNumber>
            <ecNumber evidence="15">7.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">SPHA_8400</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">Farmed</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>leukotriene C4(in) + ATP + H2O = leukotriene C4(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38963"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57973"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:38964"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Vacuole membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.47" evidence="5"/>
    <dbReference type="EC" id="7.6.2.3" evidence="15"/>
    <dbReference type="EMBL" id="CAHIKZ030000271">
        <property type="protein sequence ID" value="CAE1165293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000323">
        <property type="term" value="C:lytic vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015431">
        <property type="term" value="F:ABC-type glutathione S-conjugate transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008446">
        <property type="term" value="F:GDP-mannose 4,6-dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042350">
        <property type="term" value="P:GDP-L-fucose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18595">
        <property type="entry name" value="ABC_6TM_MRP1_2_3_6_D1_like"/>
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    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GDP_MD_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000020">
        <property type="entry name" value="ABC metal ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000924">
        <property type="entry name" value="GDP-mannose 4,6 dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Multidrug resistance-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Multidrug resistance-associated protein 5 isoform 1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
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        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
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        <property type="entry name" value="ABC1_TM_sf"/>
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        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
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        <property type="entry name" value="ABC_transporter-like_CS"/>
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        <property type="entry name" value="ABC_transporter_C-like"/>
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        <property type="entry name" value="NAD(P)-bd_dom"/>
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    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="MULTIDRUG-RESISTANCE LIKE PROTEIN 1, ISOFORM I"/>
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        <property type="match status" value="2"/>
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        <property type="entry name" value="ABC_tran"/>
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        <property type="entry name" value="GDP_Man_Dehyd"/>
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        <property type="entry name" value="TMD0_ABC"/>
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        <property type="entry name" value="AAA"/>
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        <property type="entry name" value="ABC transporter transmembrane region"/>
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        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="3"/>
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        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABC_TRANSPORTER_2"/>
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    </dbReference>
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    <keyword evidence="14" id="KW-0456">Lyase</keyword>
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    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
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        <location>
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            <end position="57"/>
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    </feature>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00024220"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00031085"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047523"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAE1165293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="2230" mass="247198" checksum="1E9BD6E5C03DB128" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B1P4</accession>
    <name>A0A812B1P4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_9697</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <location>
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            <end position="167"/>
        </location>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAE1167888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="196" mass="22833" checksum="30219D32E7BB97CE" modified="2021-09-29" version="1">MTLKCEIDCPDSVSISLSRLSIYLSIYLSIYLSIYLYDKEDTYHPLFSSPPLSLSLFLSFSSSLSLSLSFFLFSIWKILYLSIYLSIYLSIYLCLFSFFLSFFLSFFLRLLLCTASLYLSIYLSIYLCLLFSFFFLSSFFSFFLSLLLSIYLSIYLSIYLSVSFFLIRIRLHFYEQTRALSLSLSLSLSLSLSLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B1X1</accession>
    <name>A0A812B1X1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">SPHA_9310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
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            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="CAE1167255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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        <property type="entry name" value="OS08G0543275 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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            <begin position="20"/>
            <end position="38"/>
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    </feature>
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        </location>
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="357"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="391"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1167255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="424" mass="49422" checksum="D1A50EBBDBDC6A84" modified="2021-09-29" version="1">MTHLAMTPPVGEILSIYLSIYRYLFLSIYLSCSYLSVYRSRSFLSIYLSIYLSVCLSQTLSIYLSIYLSIYLFIVACFYLSMYPFEPVPFYLSIYLKLYLSIYLSIYLSIVASNSFLSIYLSILAVLMYLSIYVPILSIYLSIYLSIYTRSFLSIFLSIYLSLFVSIYLSIYLSISACSYLSISVCSYLSIYLSIYLSIYLSIYLSIYLKLYLSIYLSIYLSIYLSQTVCIYLSQTVCMYLSIYLKLYLSIYLSIVAFFICLSIYPFEPVLFYLSIYLSIYLSIYLSIYLDLFLSIYLSEAFPIYLSIYLSIYLSIYLSHSQHISLFLTLIDRSIYLSMSVSSYLSLSLSLSLSLSLYLSIYLSIYLDLFISIYLSIYLSQSVHIYLSIDLSISVCSNLSIYLSLFISIYLYVYMRLYQHVSIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B3H7</accession>
    <name>A0A812B3H7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_12176</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000404">
        <property type="protein sequence ID" value="CAE1172623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B3H7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1172623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="924" mass="103828" checksum="3E6D628ACE1C0AA6" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B4P0</accession>
    <name>A0A812B4P0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">B3GNT5</fullName>
            <ecNumber evidence="11">2.4.1.206</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SPHA_10836</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.206" evidence="11"/>
    <dbReference type="EMBL" id="CAHIKZ030000355">
        <property type="protein sequence ID" value="CAE1169937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B4P0"/>
    <dbReference type="OrthoDB" id="6047661at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047256">
        <property type="term" value="F:lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF314">
        <property type="entry name" value="HEXOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01762">
        <property type="entry name" value="Galactosyl_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="224"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="256"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="317"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="382"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="417"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="462"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="491"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="540"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="565"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAE1169937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="589" mass="69861" checksum="83C01C4899C1874B" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B948</accession>
    <name>A0A812B948_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_13782</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000464">
        <property type="protein sequence ID" value="CAE1175728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B948"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23304:SF189">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23304">
        <property type="entry name" value="SPOT2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1175728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="234" mass="26765" checksum="15A20C364DCC5AC5" modified="2021-09-29" version="1">MCLQIHLPVARLVLDEILFVREEPQHPVEPVLGDIRDEHAARLAVGGVTNVLLCPSVYVRGDLGVALASIFVDCLLDGGDEHVGLNDRRTNVVGLSFGSKFVLVLTRLTLPPNLHDHGLLETKPGHHFRRLLHVRLSVCLSVYLSIYLFLFIMHVCMYVSIYLFIFSFQFVLYLTIYLRLLSMYVCTYLSFSIYLSIYLSIYLSIYLSISVCVCMYLSIYLSIYLSIYLSIYVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BAA6</accession>
    <name>A0A812BAA6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_13706</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000460">
        <property type="protein sequence ID" value="CAE1175582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BAA6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="384"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="417"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="449"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="490"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1175582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="597" mass="70270" checksum="05AC719467D3A5A3" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BBH4</accession>
    <name>A0A812BBH4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SPHA_16729</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000593">
        <property type="protein sequence ID" value="CAE1228257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BBH4"/>
    <dbReference type="OrthoDB" id="75801at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18870">
        <property type="entry name" value="PROTEIN TAG-278-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18870:SF9">
        <property type="entry name" value="PROTEIN TAG-278-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="468"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="19"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="253"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAE1228257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="487" mass="57709" checksum="10FF31B117767F14" modified="2021-09-29" version="1">MKMAQCEKSFQESVKQICEEAEKKSKENIRIECERVQQEVSHAKDRERELLLQQMDFEKRQEMKAIHDRWSKEEQQMQNEISSLQNELQQMSSVWSAKLEEEKAKIRMEADQLEKTSQLTVSNLVEDIKQLEKSHEESVARLMDQHEANIKEMQESQLSEHKNAIEALQIAHQAVLNQLKEEHCQALKLQQEQLQQEYEQNKELLKEQLYQKHRQELCHQIEIQVKEMAAIKSDLDQLAEISKKKERDYLQDTDKLKEEIEKKEKYVKNLKCEVEKLQQTTDQLLSELDAKKKDLADTKIEQQLQLEQMEDRLIANAEKEKENIKEDHIQEMHQLVSEFSRAQQLLKNKISVLNMELLQSEERYKNRESRAEDLEEICRLRNTITDRETQMKKFQEEKRFFQMELINRETNFNKIFGSTPQVGVINPLNKKTKGGEKILRKFTSAPSLQQSLHNRLEHLPGSPVHEEHLNPIRPLPPMPPSAKKYVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BCP1</accession>
    <name>A0A812BCP1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_14950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000515">
        <property type="protein sequence ID" value="CAE1177963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BCP1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1177963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="176" mass="20220" checksum="A5CC487B9D91E64F" modified="2021-09-29" version="1">MIMMDQVTPPPALSLALSHFVSLYLLLSLTHTHTQSLSLSLSLSLSLPPSCSLCSASVIIAAVILQVFRNESIYLSIYLSIYLSIYLSIYIYITHLNQKLFLLIYLSIYLSIYLSIYIYPYKVLSFHSPSYFFAFSFPFHPVVRLHNSSSHCRHFPYRHLSSCFLHLPSCLSFQCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BD37</accession>
    <name>A0A812BD37_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ADCK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_15168</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000526">
        <property type="protein sequence ID" value="CAE1178408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BD37"/>
    <dbReference type="OrthoDB" id="427480at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13969">
        <property type="entry name" value="ADCK1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045307">
        <property type="entry name" value="ADCK1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051130">
        <property type="entry name" value="Mito_struct-func_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173:SF28">
        <property type="entry name" value="AARF DOMAIN CONTAINING KINASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173">
        <property type="entry name" value="ABC1 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="2">
        <location>
            <begin position="170"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1178408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="580" mass="66559" checksum="3DDA15867D70B987" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BEE5</accession>
    <name>A0A812BEE5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_18424</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000667">
        <property type="protein sequence ID" value="CAE1232221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BEE5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1232221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="260" mass="29826" checksum="76DA384EFF53E7F8" modified="2021-09-29" version="1">MQTIYNGRQEYLSIYLSIYLSIYLSIYLSIYLSIKVCSLSIYLSIYLSIYLSKLVSIYLSIYLSIYLSLAYFTHFFFVSLSGSLSSFSLSPLSLYYFSLCLSLSYRSQFPPLSSLISLLSLSVGLSLSLISYLSLCFSLHSLSSCFSLLCLSFSLSSLSLSLFLPYLFITYIYLSIYLSIYLSIYLSIYLICSYLSIYLSIYLSIYLSIYLSHSLSLYIYIYIYISVCSYLSLSVHTIYLSIYLFISFSVKANLQGCRQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BIB4</accession>
    <name>A0A812BIB4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_17147</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000609">
        <property type="protein sequence ID" value="CAE1229164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BIB4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="447"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="479"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="507"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="537"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="572"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1229164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="618" mass="68849" checksum="249CC13AB397C610" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BIJ1</accession>
    <name>A0A812BIJ1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_18235</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000657">
        <property type="protein sequence ID" value="CAE1231636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BIJ1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1231636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="336" mass="39011" checksum="4B4D05D39FA5AD4E" modified="2021-09-29" version="1">MFFARYLISLILSLRKKTRYCLHILSEKNFLQRYLIKNRLSRIISPELFSKISISLSQNWLSLGNVLARYLISLSIENRIVSRYLISLSLVLSLGRISLASPENNCLVLSLGKMFFARYLILSIENRIISYYLSNVLASYLIILSIENRICLVLSLGRMLALENLPSISPRYLISLHRKQNCLVIYLSEECFLQAISLVSLHRKQNCLVVSRKMFLQRYLIKCSCKDISLVSPDKKNCLVLSLGRMFLQDLISLSRKQNCLILSLGRMFLQDISLVSLQKTELSLVLSLGRMFLQRYLISLSIENIGELFLYYSRKNVLCKISHYSLHRKQNCLWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BIV3</accession>
    <name>A0A812BIV3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_18223</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000657">
        <property type="protein sequence ID" value="CAE1231616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BIV3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1231616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="328" mass="38230" checksum="8AA8F8B3201FD3C3" modified="2021-09-29" version="1">MGNSLRQSTDDDLSIYLSIYLSIYLSIYLNLLKFVSRFIHIYHSVFISIYLSIYLSIYLSIYLIRIDIYLSIYLSIYLSIYLSIYLSRNRYINGRAHNYLHIISYLSIYLSIYLSIYLSQPIQIYLSIYLSIYLSIYLSEPIHNHLSIYLSIYLSIYLSIYRSLFITIYLSIDLSIYLSIYLSITTYSDLSIYRSIYLSISTCSYLSIYHNLFISIYLSIYLSITIYAYLPISACSYLSIYLSIYLSIYLSIFPQPVNILSTYPNFCISLSLSIYLSIYLSIYLSIYLSIYLRLLSYSGASRPQLCLYVYVAPITASVEDLPSGLPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BJ30</accession>
    <name>A0A812BJ30_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_17027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000602">
        <property type="protein sequence ID" value="CAE1228775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BJ30"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="337"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1228775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="415" mass="47767" checksum="80BB57C8A41C4F3D" modified="2021-09-29" version="1">MFLCFSLCIFLYLYFHYPFCNILLFFFIGIIRTPNPPKYIFSSSSSYLFLSLSLPLYLSVFLCHAIYLSIYLSIYLSIYLSIYLSIFYSFSNIPTFYSISSPSFARSFPPVSLILCLSFSVSLSLSLSLSLSLSLSIYLSIFFIFFFFLEYSHIYSFSSPTFLPLTPARLSHSLSIFLCFTFSLSLSLSLSIYLSSYLLFFLEYSHILFLFITDIRPLTPARLSHSLSIFLCFSLSLSLSLSLSLYLSIYLFISFIHSRIFPHFIPFHHPHLPAHSRPSLSFSVYLSLFLSLSLSLSLYLSIYLSSYLLFFLEYSHILVLFITVIRPLTPARLSFSLFLALYLSIYLFLSLHIAYPFSNILLFCPSSSPSFTQSHAHSLYFSFPSSSLSPLFVFLPLCHYFSESLPPSFFLSMVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BKI7</accession>
    <name>A0A812BKI7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_17257</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000613">
        <property type="protein sequence ID" value="CAE1229335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BKI7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="333"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="396"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="427"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1229335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="460" mass="51434" checksum="82792EE62250F183" modified="2021-09-29" version="1">MSSIKLSFSFMRFVLCSFFRHKFSFAFIYSPSLIFIPSLTRLPSCQFFFSFSLFIHFFLFLLFFLLFYVSLFGPFFFSLAFPLSFSVHCPLSLFLSALPSLSLSQCIALSLSFSVHCPLSLFLSALPSLSFLSALPSLSLFSVHCPLSLSQCIALSLSFSVHCPLSLFLSALPSLSLSQCIALSLSFSVHCPLSLFLSALPSLSFSVHCPLSLFSQCIALSLSFLSALPSLSFLSALPSLSLSQCIALSLFSQCIALSLFFLSFLSALPLSLSLSALPPLSLSLSVHCPLSLSLYPPLAALGVFSSLFYTVIAFCLLPLLFTSCFSFLSLLDLLLLSNSFLLFLFLSLSFCFFSSIFPSVSFLFHHVCLYYFPISFPCFFFSVTILQHSHFINHSFFLLTSVFFLSTFHYPFSFSLLSYLFSYLFSYLLNIFMLLLLIFNCLFFHFNFSFSFLSSLLHSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BMB8</accession>
    <name>A0A812BMB8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_19978</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000728">
        <property type="protein sequence ID" value="CAE1235925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BMB8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="397"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="453"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="493"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="524"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="559"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1235925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="585" mass="65438" checksum="751CD31664EC3FCA" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BNA0</accession>
    <name>A0A812BNA0_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.143</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">Beta-1,2-N-acetylglucosaminyltransferase II</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">GlcNAc-T II</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Mannoside acetylglucosaminyltransferase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">SPHA_23660</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="27">Farmed</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>an N(4)-{beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = N(4)-{beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12941"/>
            <dbReference type="Rhea" id="RHEA-COMP:13526"/>
            <dbReference type="Rhea" id="RHEA-COMP:14369"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:60615"/>
            <dbReference type="ChEBI" id="CHEBI:60651"/>
            <dbReference type="EC" id="2.4.1.143"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 24">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 16 (GT16) protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="27">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.143" evidence="5"/>
    <dbReference type="EMBL" id="CAHIKZ030000876">
        <property type="protein sequence ID" value="CAE1243178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BNA0"/>
    <dbReference type="OrthoDB" id="6019616at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008455">
        <property type="term" value="F:alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009312">
        <property type="term" value="P:oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007754">
        <property type="entry name" value="GlcNAc_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12871:SF0">
        <property type="entry name" value="ALPHA-1,6-MANNOSYL-GLYCOPROTEIN 2-BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12871">
        <property type="entry name" value="BETA-1,2-N-ACETYLGLUCOSAMINYLTRANSFERASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05060">
        <property type="entry name" value="MGAT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15 25" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 27" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="17 24" id="KW-0464">Manganese</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 24" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="26" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="8 27" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="26">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032426025" description="Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase" evidence="26">
        <location>
            <begin position="18"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <begin position="64"/>
            <end position="68"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="31"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="118"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="213"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00029663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00031203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00032552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00032915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00093257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRSR" id="PIRSR607754-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PIRSR" id="PIRSR607754-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PIRSR" id="PIRSR607754-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="CAE1243178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="284" mass="33300" checksum="B6B44B451914F857" modified="2021-09-29" version="1">MFLLFQVIQIFFPHSLQLHPQEFPGEHPNDCPRNVNKAEAMKIDCNNAASPDRYGHYREAKYCQTKHHWLWKLSHVFEKIKVMKGYEGIVLLLEEDYYVSEDIITVLQMLQNLRKKDCKDCKILTLGNYDKTQNYALNAGKVEIARWVSSRHNMGMAFTRQMWEDIKKCGVDFCHFDDYNWDWTLQHLSMKCIPGTVKVMKMKATRVFHMGACGVHHKGKNCSPESKKKAVEKLLWDNKQNFFPNVLNLAGYSGLRLHHFSFFLPLTLQPAHMKLIFLYLLKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BNB0</accession>
    <name>A0A812BNB0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_22062</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000813">
        <property type="protein sequence ID" value="CAE1239922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BNB0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1239922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="405" mass="45214" checksum="359D77020B2DB04A" modified="2021-09-29" version="1">MHSIHPSTYLYIAMFTHIYLSIYLSIYLSIYLYVYSYLSIYLSIYLSIYRYVYSYLSIYLSIYLSIYLSIYHHVCSYLEVVHIITCDITILIFACINHILILGLFRASSNHICIRGLFPASSNHIRILDLFPASSNHIHILDLFPASSNHIRIPGLFPASSNHIRILGLFPASSNHIRILGLFPASSNHIRIPGLFPSSSNHIRIPGLFPASSNHIRILGFFPASSNHIRILGLFPASSNHIRILGLFPASSNHIRILGLFPASSNHIRILGLFPASSNHIRILGLFPASSNHIRIPGLFPASSNHIRIPGLFPASSNHIRILGLFLLQTYIRILGLFPASSNHIRIPGLFPASSNHIRIPGLFPASSNHIRILGLFPASSNHIRIPGLFPVSSNHIRILGLFPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BT46</accession>
    <name>A0A812BT46_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PITX2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SPHA_22264</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000822">
        <property type="protein sequence ID" value="CAE1240328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BT46"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003654">
        <property type="entry name" value="OAR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45882">
        <property type="entry name" value="PITUITARY HOMEOBOX HOMOLOG PTX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45882:SF3">
        <property type="entry name" value="PITUITARY HOMEOBOX HOMOLOG PTX1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="OAR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="OAR"/>
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        <location>
            <begin position="145"/>
            <end position="166"/>
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        <location>
            <begin position="178"/>
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        <location>
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            <begin position="241"/>
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        <location>
            <begin position="102"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAE1240328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="347" mass="39708" checksum="136258DAC2952D5E" modified="2021-09-29" version="1">MQPTFDDSLYTGYSYNNWATKVPSPLGPKGFSWGLNSVNHLPSVVTTQPMCFSSPASSISNSMVPGGVPSVASMGNVASPTTPCPYAPPAPPYIYNRDQCSTSIASLRLKAKQHSPFNYPTVPPRQPTLSACHTDSSFFLIFPSYFPSLLLFFSFYACLLHSFILFHILPSFPSLLPYLLLSFSLSFPLLFSLLLCFFLFFFTSFFTSFFSSFYSSFSSLLSLLLSFLLFLLYFFLFFFSFFTSFFTSFFASFFLTLFQFISLSSFPSLPPPFLFFFLFFFFLLYFLLYFFLCFFLSNFISVYLAFFFSFFTSSFPFFLSFLLFPSLLPSLLLSLLLSFFHSAYLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BW57</accession>
    <name>A0A812BW57_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_25126</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000950">
        <property type="protein sequence ID" value="CAE1246391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BW57"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="215"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="245"/>
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        </location>
    </feature>
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        </location>
    </feature>
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            <begin position="304"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="431"/>
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        </location>
    </feature>
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        <location>
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        </location>
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        <location>
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        </location>
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        <location>
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        </location>
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        <location>
            <begin position="1177"/>
            <end position="1198"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAE1246391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1223" mass="140795" checksum="C01DFD412BE9E380" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BWN6</accession>
    <name>A0A812BWN6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_25489</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Sepiina</taxon>
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            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000966">
        <property type="protein sequence ID" value="CAE1247101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
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            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="248"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1247101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="276" mass="32068" checksum="0C51B1F3CF312930" modified="2021-09-29" version="1">MPSSGQTNKIIEKLHHMHVPVYLSLLFKAQLVPIYLSIYLSIYLSIYLSIYLSLFISKFLKIYLSIYLLSLYSYLSIYLSLFSVHICIYLSIYLSIYLSIYLSLLKSIYISIIFSLFVSISVHLYLSIYLSISSVSAFTYMANYLSIYLSVCISIYLSIYLSVCISIYLTISVFHAIFSLFIFISVFSYLSIYLTFSYLSQFFHVYFSFSYLSIYLSIYLSIYLSQSFHIYFSLFISIYLLQRNDQDERVGDDDDGDSHAGGDDGGSRETQPKHHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C062</accession>
    <name>A0A812C062_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_27267</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Lophotrochozoa</taxon>
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            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
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            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001051">
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    </dbReference>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1250809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="285" mass="34710" checksum="6F49EFB854807B61" modified="2021-09-29" version="1">MFNQCGDETRLPVSLRRMFNQCGDETRLPVSLRRMFNQCGDETRLPASLRRMFNQCGDETRLPVSLRRMFNQCGDETRLPVSLRRMFNQCGDETRLLFVFFRAFSFYFFFLISSLHFRLSFPYIITLSSIRFFNRILSPFHFLIVFFRPSIFYSFSFVLPFFNRILSPFLFLFVFFRPSIFYSFSFALPFFIHFLSSFHFLFVFFRPSIFYSFSFALPFFIHFLSSFHFLFVFFRPSIFYWLVFFRLYIFCSLSFILYLFSTFFLLTFLFYSLSFVLSFFFAYSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C1D0</accession>
    <name>A0A812C1D0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_27624</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Coleoidea</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001079">
        <property type="protein sequence ID" value="CAE1251656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C1D0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134:SF22">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134">
        <property type="entry name" value="OS08G0543275 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
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            <end position="348"/>
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            <end position="218"/>
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            <end position="250"/>
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            <end position="275"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="287"/>
            <end position="310"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="322"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1251656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="348" mass="41595" checksum="0FBA00ECF2013907" modified="2021-09-29" version="1">MLNFSFFLSFFLSFFLSFFLSFFLSLNPTRATSTEPNHAHFRCFPTIKSIYLSIYLSIYLSIYLSYSINIYQSISFYSYLSISFYSYLSIYLSIYLSISFYSYLSIYLSIYLSILFYSYLSINLILFISIYLSIYLSIYLSIYLSRLFFFFFLFPVQQLILFFSSTKSAYNLSIYLSIYLSIYLSIYLRLFLTLYTHLCMYVCIYVCMYLSIYLSIYLSHSLHKNLCSYLPYSIHIYHILLISIYLSIYLSMYVCMYVSIYLSIYLCIYLSISLCSYLPHSIHIDHIVLISIYLSIYLSIYLSIYLSIYLCLNFSLFLLPRFFFVYTPFLSIYLSIYLSIYLSIYLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C2K2</accession>
    <name>A0A812C2K2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">SPHA_27319</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
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            <taxon>Eukaryota</taxon>
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            <taxon>Sepiidae</taxon>
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            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
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    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001054">
        <property type="protein sequence ID" value="CAE1250912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
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    </dbReference>
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            <begin position="47"/>
            <end position="71"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1250912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="163" mass="18370" checksum="17902006C572CCED" modified="2021-09-29" version="1">MFTLKPGFFFFSLSSLSFSFSVCLSLSLSLSVSLSLCISHAFYLSRFLSFARAISLYLSLSLSLSLAFSFSLSLSHTFSLFRFLSRLLSISLFLSLSLSHFLSLSLSFFLSFSLCLFFSLSLFMIAPPSSLTHIHTYTLVSAHAHMVSTKTWKSVRTRYMKHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C4T3</accession>
    <name>A0A812C4T3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_28274</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Lophotrochozoa</taxon>
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            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="488" mass="57086" checksum="89FF20C479DB0E1C" modified="2021-09-29" version="1">MGIKQNSLKNVTYFKIIYLSIYLFIYLFIYLSIYLSIYLSQSIIIFFLSFTYYLSIYPSLFISIYLSIYLSIYLSIYLSISVYYYFLSFFLSFFLSFFLSFFHLLSWSVTIYLSIYLSIYLSIYLWEQFITVFPPLNLLTLHRHFTFFQLFTFLFSSFIIFSLHHYPIIVSSFSLPCFNRSPNNLLSLISFFYFNTSFLSTAQIFTAVLFSSVSNILFFFITIISFILFLLFLFISISSFFLVLSFFFKLLFICFFFLFVLHFKSLFVLFASPSSANLLLIFSLLILSPRLSLPTPPSSPSFFLSIDLHFFFSFEKKTDNINITIFIRILFSLYSSSGLTFILFLHFICIFPPFFFFCFFLLFLTCLPSSLYLSTLFSLFLPYISLIPSVAFHITFLLFRRSVVLSLSLSLSLPLDLSCYQNVLLPFHLMSSLPSLFIRVLHFHRIFPAIATYAILGGLAAEEMSTDKPDSICRPLLISARIFLSLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C562</accession>
    <name>A0A812C562_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_29770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
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        <dbReference type="NCBI Taxonomy" id="158019"/>
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            <taxon>Acanthosepion</taxon>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001191">
        <property type="protein sequence ID" value="CAE1255656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C562"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134:SF22">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134">
        <property type="entry name" value="OS08G0543275 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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            <end position="34"/>
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            <begin position="615"/>
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        </location>
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        <source>
            <dbReference type="EMBL" id="CAE1255656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="637" mass="76472" checksum="D7A643517839C6B7" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C5C8</accession>
    <name>A0A812C5C8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_30337</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
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            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001218">
        <property type="protein sequence ID" value="CAE1256702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C5C8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="334"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1256702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="352" mass="40777" checksum="4EC16181BA3750CC" modified="2021-09-29" version="1">MNRNRLIANSNIYLSASPSLIYLSIYLSIHLSIYLSIYLSLSLLSLSISAFSNLSIYLFIYLSISVFSLSLSIYLSIYLSIYLSISSYSNLSISQRSSIYLSIYLSIYLSIYLSVLIYTYVSMSLSPEQRDAMAFCPLPYSFPFLVRWPVTRLLLDHCHLAEPRHHVCFSCQSDKSIGDVSPLSLGFQPIHLVCSMLLTAQLSVNISSKPYDKNGQLLSQRQFHWSRILTHKKKTYMCAYTCASYYLSIYLSIYLALFTIDLLRFITYLPMYLFIYHCSLSIYYDSLYIYLSIYLLVNIEFYIHTESIYLSIYLSIYLSIYLSIYLSQPSPTNLPIYLSIYLSIYLSIYLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C621</accession>
    <name>A0A812C621_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_33280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001392">
        <property type="protein sequence ID" value="CAE1262544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C621"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1262544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="222" mass="25089" checksum="0131613FB2F56B04" modified="2021-09-29" version="1">MEWSRQLIKQGIVRSITWVDKNLSIYLSIYLSICFTLLLSYFNSSFPSVFATVSFFLFYGLSYSFAVCKFVSSFLSLFILLSPLLRSTGASLSPPSLSLSLALWMQTLPPALLQKEADSKSFPVTTSHVDHLSLSSHTQLHKVSHLVLSPLTRYLSIKFVLYNQSKSINLSSPSSIYLSNTICGQSIYLSIYIYLYLYIYGYGLILLSLSLYLSIHFGLNYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C8A6</accession>
    <name>A0A812C8A6_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SPHA_29607</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001180">
        <property type="protein sequence ID" value="CAE1255453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C8A6"/>
    <dbReference type="OrthoDB" id="6162784at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099503">
        <property type="term" value="C:secretory vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052095">
        <property type="entry name" value="UNC-13_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45999">
        <property type="entry name" value="UNC-13-4A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45999:SF4">
        <property type="entry name" value="UNC-13-4A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="316"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="360"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="395"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="434"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="463"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="495"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="526"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="556"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAE1255453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="591" mass="67163" checksum="5E79E7D34CCD9BD8" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C9Z9</accession>
    <name>A0A812C9Z9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SPHA_32923</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001371">
        <property type="protein sequence ID" value="CAE1261842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C9Z9"/>
    <dbReference type="OrthoDB" id="6162141at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06263">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000998">
        <property type="entry name" value="MAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051560">
        <property type="entry name" value="MAM_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23282">
        <property type="entry name" value="APICAL ENDOSOMAL GLYCOPROTEIN PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23282:SF142">
        <property type="entry name" value="MAM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00629">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00137">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50060">
        <property type="entry name" value="MAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0768">Sushi</keyword>
    <feature type="domain" description="Sushi" evidence="4">
        <location>
            <begin position="7"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="3">
        <location>
            <begin position="52"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAE1261842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="229" mass="26147" checksum="EA848FD55CF5B880" modified="2021-09-29" version="1">MLATCASSCPRIRRNKNLRLKYRSNKRIVYFACRSGFKIIGATSAICNKNTWSTDSPICVAPGCPLLEYDDNVLDVTYTYRHYIYIEASAPRRPGDQARLLSPLYNFKMQAVCFEFWFHMWCPSLTKETGSLQIYAISKKQLLSNLAPLMTLTGDYGNSWKRKRIQLEPMQDTFQIILHATRGQNHQNDIAVDDIQLWAGLCDGNIQHINGGLSEDWFMISNVVDSFGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CBJ9</accession>
    <name>A0A812CBJ9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_36412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001591">
        <property type="protein sequence ID" value="CAE1269023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CBJ9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1269023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="259" mass="30827" checksum="FBB375091B92556C" modified="2021-09-29" version="1">MQRNVHVPLFIATFEIFSSFEIFVPFDFSFFLSFFLSFFLPSFLSFFLSSTLFLSFYIPLFFAFLYIHYFFLPTFISSFFYFSLFLSRGCFPFPFLLFIFLFFFLSFFLNSCSTFFNFILPLYFFYRSLFLTSLCLSFTFGFPFSLLSFFLSFLLCLFSFHSCRVDSQIIRPLQAKVLRVNVIIISVFSFYACRSWRNCSIDLSIYLSIYLSIYLSISVCSYLFISVCSYLSQSVHIYLCMYLSIPVCSLSIYLHIYLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CCS0</accession>
    <name>A0A812CCS0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PCYT1</fullName>
            <ecNumber evidence="2">2.7.7.15</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_31091</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.15" evidence="2"/>
    <dbReference type="EMBL" id="CAHIKZ030001264">
        <property type="protein sequence ID" value="CAE1258150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="17102at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004105">
        <property type="term" value="F:choline-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="359"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="454"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="496"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="528"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="559"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="586"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="639"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="679"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="704"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="730"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="762"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="800"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="835"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="963"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="986"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1018"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1052"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1088"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1130"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1273"/>
            <end position="1293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1258150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1297" mass="144127" checksum="CA71DB4BBD9D4AAE" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CEB9</accession>
    <name>A0A812CEB9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_32641</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001360">
        <property type="protein sequence ID" value="CAE1261284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CEB9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1261284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="210" mass="25417" checksum="47FC4FDC8C297198" modified="2021-09-29" version="1">MVFIPSSYFSQIHFLSLYLYFCRSPLFISIYLSIYLSIYLSIYLSISVCSYASISVCSYLSIYLSLLYISLYLSLLISIYLSIYLSIYLYTASFFLSFFLSFFLSMLESLYLFNSLPLITHFVHYFFLSLFFFFFLSFFLSFYLSIYLYTFYSKYNVFNNINQSNKKFFTASIYLSIYLSIWLRVCIYWIIYLSIYLSNFIHMYLSIYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CEJ2</accession>
    <name>A0A812CEJ2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_32850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001369">
        <property type="protein sequence ID" value="CAE1261509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CEJ2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="86"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="210"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="309"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1261509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="329" mass="38677" checksum="059FD354F20E0334" modified="2021-09-29" version="1">MKYRVPNIYGGVGKCGGNIFFLLNTSFETDFRRTFYVSNISHLEILLLYLSLFIFSSIYLSIYLSNSIHIYIAYLSITSIYLSIYLSHHLSIYLSFNSIHIYISSSIIYPYLSIHLSHSIHISHSIHFSHYLSILISIYLSIYLSIYLSIYLSIIQFTYIAFSSLSIYLSIYLSIYLSIYLIQFTYIAFSSLSIYLSIYLSIYLFTYIAFNSYLTHLIIIIHSSIYLSIYLSIYLSILRFISIGFNLYLNLFTIYLSIYLSIYLSIYLIQLISIYLSIYLSIYLSIYLSIYLIQFTYIAFNPYLAQSDHYLSIYLSIYLSIYLSIYLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CG50</accession>
    <name>A0A812CG50_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_36418</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001591">
        <property type="protein sequence ID" value="CAE1269056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CG50"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032543468" description="NADH dehydrogenase subunit 6" evidence="2">
        <location>
            <begin position="17"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1269056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="218" mass="24074" checksum="FAEEFB5B3CBF9FC3" modified="2021-09-29" version="1">MISYFALSLSVSLTLALSVCLSRSLSVSLSLYLSLSLSLCVSLLLSLTLSDCLSFSLSLSLCLSVPLSLSLSRVLSVSLSLSLSACLSVSLFHFSLSLSLSVFIIIVIIIVIIVVIIVIIIVVIIIVVSFHIFIFFSFSILSFLLPSFSFSFFFSHQFFFSLLSHHLLLFTSLLSHRHKHFLSHHHFLSIISLSLIYFWNSLSLSLSLSLSLSLSLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CG61</accession>
    <name>A0A812CG61_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_35151</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001510">
        <property type="protein sequence ID" value="CAE1266398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CG61"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1266398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="184" mass="21774" checksum="04D9A54DD35B6B38" modified="2021-09-29" version="1">MLHSYQEAGHRRQIESMLHSYQEAGHRPQIESMMHSYQEAGHRRQIESMLHSYQEAGHRRQIESMLHSYQEAGHRRQIESMLHSYQEAGHRRQIDSMLHSYQEAGHRRQIESMLHSYQEAGHRRQIESMLHSYQEAGHRRQIESMLHSYIGAKSILCCILIKKLAIGAKIDSYMLHVHLSRSWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CI19</accession>
    <name>A0A812CI19_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_37395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001668">
        <property type="protein sequence ID" value="CAE1271786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CI19"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1271786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="280" mass="32081" checksum="857E221669E186D3" modified="2021-09-29" version="1">MYRLPLQVYYLSFSLSLSLSLSHSLFIWKTVSSNPLFIHLSIYLSIYLSIYLSIYLSNSVHVYCILNVCGHAHIGFRCDIYFSPSNSFILSLIFSLLAHSSLFINLSLSLSLSSLSTLLSSPSHSLPFLSLPFPITFSYYFPLRHFCYFPPSLSLFYLSLLYYSLLVYSFPAFLSRYIFRNSLLFYFSLSLSLSLYLSLTPLSCSSVFLYLSIVLFSLSLHASSLSTIFSLHPLFLSSFPSTLARECSFFLSFFLSFFLSFFLSFFLSFFPFSLPLILTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CLN0</accession>
    <name>A0A812CLN0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_37840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001701">
        <property type="protein sequence ID" value="CAE1272821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CLN0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1272821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="210" mass="25348" checksum="2B7C105871906C68" modified="2021-09-29" version="1">MQVQINLSSKFFSNFSSLLSNAFIYFFFIIIFPLFSPFFYLIPSSFILFFFIFTFSFKNSHFLFSMFLSSHFLFTFLSFHQLSFFVHFFLFFITIFFSFCYLTDSFCFIFHFSDNFFSLSHLIPAPFFSLSSLFLHIHTFPSSKYVSFLFNLIFSFILFLPSVIHIFSFSLKFFLSFFFSFLSFTHSTVAIFYQPHWSYLNKIHFKYIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CPQ3</accession>
    <name>A0A812CPQ3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_39401</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001825">
        <property type="protein sequence ID" value="CAE1275328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CPQ3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1275328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="195" mass="23051" checksum="E2FE7693452E2020" modified="2021-09-29" version="1">MRRVVCILHRIFSIFHLSLLSSLRLPLSHLLSDALLHCQHRFPPSHSVCRFLFSSLYSPSLTLFLFISLFLSLCLYLYRVLSFLLSLSRLHSLTLYYSLCYHSLFLFVIFYFHLSPYPLSLSIYLTLSFFLSVSLSHCVYTPFHFLNISTPFSSCLSLSETESKRERNKWKKKRGNRHSVIERQKESVRQTNKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CQ73</accession>
    <name>A0A812CQ73_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_39839</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001868">
        <property type="protein sequence ID" value="CAE1275973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CQ73"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="287"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="312"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1275973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="348" mass="41470" checksum="BC9206DC64089841" modified="2021-09-29" version="1">MAFAVIPNPTFCSHISPHAGKATSSLEYNNNLGLFSFFSSVSDFISSLVYTFFHPFFHSFVHSFFLSFFLSFLLFFLHFFLVLITFFYFVHLISFFLSFFLSFLSFFVSFFLSFFLFVFCPLHPSLLSFFLSFFLSFFLSTLKIINLFVLSSSLLFFLSFFLSFFLSYHFFLFIHDHNTFFLSFFSFLLTISFSLSIKIILFFLSFFLSFFLSFCLPLVSLHPSLFFLLLILSFWLTTSFTLSMFVDLLPLLCFHYYPLIFHSFFLSFLLFHNSFILSLFLENYYPFLSFFLSFFLSHTSHYFIFSIFHCKFFLSFFLSFLLSYLLSFFLSFLSFFLSLCILLTFSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CRM7</accession>
    <name>A0A812CRM7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_38821</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001780">
        <property type="protein sequence ID" value="CAE1274336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CRM7"/>
    <dbReference type="OrthoDB" id="6131137at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="195"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1274336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="218" mass="24564" checksum="88316CF4220BCCEC" modified="2021-09-29" version="1">MHRLVKRYLFKLERAKDEKENVKDVANIRAEEIELFETPPDGPPPVPETPSRIPYATPPIPEDEDVEAKLSAKNASHLRKKGASRCLNRRSSVCNSGPIATTLAIPQLDAIQRQQKLLDVRLQHLQSNTRENNKMMDDVEFIRRLMTENQKALFNVIQALANIQTEIVNLAQCLRPPSPKPQLKQGSTHSRGGQSNSTNTSSNSAQPRRQSKEEESKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CT73</accession>
    <name>A0A812CT73_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">poly(A)-specific ribonuclease</fullName>
            <ecNumber evidence="5">3.1.13.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">SPHA_40197</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">Farmed</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage of poly(A) to 5'-AMP.</text>
            <dbReference type="EC" id="3.1.13.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CAF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.4" evidence="5"/>
    <dbReference type="EMBL" id="CAHIKZ030001897">
        <property type="protein sequence ID" value="CAE1276727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CT73"/>
    <dbReference type="OrthoDB" id="1164111at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000005">
        <property type="entry name" value="CCR4-NOT transcription complex subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039637">
        <property type="entry name" value="CNOT7/CNOT8/Pop2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006941">
        <property type="entry name" value="RNase_CAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10797">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04857">
        <property type="entry name" value="CAF1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0678">Repressor</keyword>
    <keyword evidence="13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="15" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="16" id="KW-0804">Transcription</keyword>
    <keyword evidence="14" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="12" id="KW-0810">Translation regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="307"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="307"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CAE1276727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="330" mass="37740" checksum="178EB4306E6F0EC1" modified="2021-09-29" version="1">MCDTDFYQIPKDINEVVYSQVNDHSGQYNVRMPSVAQADYSIRDVWQSNLEQEFRTIRQIVQSYKYVAMDTEFPGVVARPIGEFRSNADYHYQQLRCNVDLLKIIQVGMTFLDEYGHTPTPISTWQFNFKFNLTEDMYAQESIDLLTNSGIQFKKHEEEGINTDDFAELLMTSGVVLTDEVKWLSFHSGYDFGYMLKILTNSNLPAEEADFFELLRIYFPNIYDVKYLMKSCKNLKGGLQEVAQQLEIPRVGPQHQAGSDSLLTGAAFFNMREMFFEDNIDDAKYCGHLYGLGSNYIMNGSSNYENHVSQTNSSVAPNNDEAGPSHSNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CUM4</accession>
    <name>A0A812CUM4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_40222</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001901">
        <property type="protein sequence ID" value="CAE1276796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CUM4"/>
    <dbReference type="OrthoDB" id="5980721at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF284">
        <property type="entry name" value="EG:103B4.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="433"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1276796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="465" mass="51969" checksum="E7106A3080A7F352" modified="2021-09-29" version="1">MLKIQMQVSSLQEACTSCVCFQWFYWLIRLKSLSLMMTNNTYIHHSYIFCMYILSLSLYLSIYLSIYLHIPMFETVWKTRRLDSIRFRQFSCLCGERPKTVVASRCFHSHCLSLSLSLSLSLSTAWLQNTAGFIRYTLLQNADPNETRYITWITSIYAGMVNAVAPIASLFVYKYGCRTSVIVGGTFETLGFVISYFTREKWVYFISYSLMSGLGSGLTFITAMVILNFNFERYLSVASGISCSGQGIGLTFMPIITNFLFEKYGLQGTFLLLGGITLQKCIFGGLMRPSALELDQISKFGKTKTIKNPKCLKDLPKSAEFEDQVSVGADTENAQIQEEFRQSCISDILPNEHEIEEEGKSGQSFIVSAVLEDEAEAKDWSVHVISGEENMAITGIDNSTAAFGFVIFTKAVAGIFGPPLADAIAASAQDSNACFFLSGCMYIICMLSMILLNDGSERFVNNDIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CUW5</accession>
    <name>A0A812CUW5_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">tRNA:m(4)X modification enzyme TRM13</fullName>
            <ecNumber evidence="12">2.1.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SPHA_45323</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Farmed</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>adenosine(4) in tRNA(His) + S-adenosyl-L-methionine = 2'-O-methyladenosine(4) in tRNA(His) + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43196"/>
            <dbReference type="Rhea" id="RHEA-COMP:10401"/>
            <dbReference type="Rhea" id="RHEA-COMP:10402"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74477"/>
            <dbReference type="EC" id="2.1.1.225"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>cytidine(4) in tRNA(Gly)(GCC) + S-adenosyl-L-methionine = 2'-O-methylcytidine(4) in tRNA(Gly)(GCC) + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43192"/>
            <dbReference type="Rhea" id="RHEA-COMP:10399"/>
            <dbReference type="Rhea" id="RHEA-COMP:10400"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.225"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>cytidine(4) in tRNA(Pro) + S-adenosyl-L-methionine = 2'-O-methylcytidine(4) in tRNA(Pro) + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32767"/>
            <dbReference type="Rhea" id="RHEA-COMP:10397"/>
            <dbReference type="Rhea" id="RHEA-COMP:10398"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.225"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the methyltransferase TRM13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.225" evidence="12"/>
    <dbReference type="EMBL" id="CAHIKZ030002334">
        <property type="protein sequence ID" value="CAE1285257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CUW5"/>
    <dbReference type="OrthoDB" id="258806at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106050">
        <property type="term" value="F:tRNA 2'-O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007871">
        <property type="entry name" value="Methyltransferase_TRM13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039044">
        <property type="entry name" value="Trm13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022776">
        <property type="entry name" value="TRM13/UPF0224_CHHC_Znf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021721">
        <property type="entry name" value="Znf_CCCH-type_TRM13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12998">
        <property type="entry name" value="TRNA:M(4)X MODIFICATION ENZYME TRM13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12998:SF0">
        <property type="entry name" value="TRNA:M(4)X MODIFICATION ENZYME TRM13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05206">
        <property type="entry name" value="TRM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11722">
        <property type="entry name" value="zf-TRM13_CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05253">
        <property type="entry name" value="zf-U11-48K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51800">
        <property type="entry name" value="ZF_CHHC_U11_48K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 12 14" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 12 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="8 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CHHC U11-48K-type" evidence="13">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAE1285257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="464" mass="53418" checksum="9370AB11B5657BDA" modified="2021-09-29" version="1">MASASTSSKKEVIPACSFFLTKKKRYCRFRPCNDQKYCSEHIYLLNDESDRKRIPCPLDPNHTVYEDNVDTHIKKCNKRQHTLPPYYVAGINSGNTAKEKIQENKLTVLTASSNEISQAITKVKQLYQKYLSGIKKEELWHECMTKEMANPYYGIQAQRQRKQQASLVSHLEKNYLLKTGSIYVELGAGKGQLSHWVQKATSDDKNSLFILVEKGHIRHKFDRQHHYEEGGPKFQRLNIDLEHLNLAKVEDIANSEQPVVGMGKHLCGAGTDFALRCLIESMRNKQNIMSNSETKISHSSQLAGVVLAPCCHHRCSWTAYVGKKFFQENNLTSSQFHLMSSMCSWATCSWKGWREQEMTNSKHNDMQDDAMEDAIKENDQFYSINEHENNKDEQNLESKIRTNLKFSVEEREQIGRNCKRLIDYGRLQYLKEAGLEVSMKEYIDGNLTPENIVLIAKNVLKLCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CY80</accession>
    <name>A0A812CY80_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_46856</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002502">
        <property type="protein sequence ID" value="CAE1287965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CY80"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1287965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="256" mass="30147" checksum="BA12187665982793" modified="2021-09-29" version="1">MGWKNPNSSSYSLFANSCREKHIYLSIYLSIYLSIYLSISVCSYISIYLSILVCSYLSIYLINYLLSIYLSIYLSNISMFIFILSIYLLFIYLSQYVMIYLSIYLSISVSFINIYLSQYVYIYLSIYLPIYLSIYLFVCLYPSVSYLSIYQIYLSQYVRYLSGISIYLSINLSIIYLLNMYLSYLNSIYHLSISLLFISIYLSIYVSIYLSMCDIYYLSIYLSIYLSQYVSSIYLSISVCSDASIYLSIYLSIYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CZH2</accession>
    <name>A0A812CZH2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_44649</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002280">
        <property type="protein sequence ID" value="CAE1284244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CZH2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1284244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="201" mass="23756" checksum="324B35992E337D76" modified="2021-09-29" version="1">MFSFFCGESKYCSNLFLSFFFFFFFFFFFFFFFFFYVPYTLLSLSLSLSLSLSLSLYHTGTPLHAAFDTCIQDLSLSNGGNFIFFFLLRFFFIVLVFFFSLFLLSCPLHSSLVTLFKNFMHPFTFHLLLLSFHTSFSRYFFLPLFTIFTFFPLLLPSYLSRLLKSSLIQTSQNRGKSSLSPPKFIRKSLDSPRRQSRDSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D0V5</accession>
    <name>A0A812D0V5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_47342</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002556">
        <property type="protein sequence ID" value="CAE1288787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D0V5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1288787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="277" mass="31671" checksum="9AD7C6C0BB5884C7" modified="2021-09-29" version="1">MVAIILLCSYLSIYLSIYLSIYLCVYIYWSKTFVPPLNFTPFYFLTYLFSIFLFLYLCSSLNVPHSLSFSFSLSLSHTHTVFPYHIFYSLIVSPHLSLPLLLFLNLSLFYYFLLSECLLDSLFTTLSLFLILFCFSLLISHSFSLLICCFTCFFLSFLLSTKLSLSPTAFTFLFSLSVCLTPFLTLSLSLSLSLSLSLSLSLLQAPLSFTRSFFLATLSLFFNLRFSASLFCHSLILSLSPRPFLLSFFLSFFLSADYIFVNSLPLSLSSHLDVYIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D1P1</accession>
    <name>A0A812D1P1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_45855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002390">
        <property type="protein sequence ID" value="CAE1286210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D1P1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1286210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="168" mass="19263" checksum="837AFB158601E801" modified="2021-09-29" version="1">MTTFFLSIYLSIYLSIIACLRLYSLFKLSIYPSSIYLSIPVLSIYLSSIYLSQFYLSIYLNLSQFNLSIYLSQFNLSIYLYQSVQSIYLSIYISQFNPSIYLSISVSSIHLSIYITSHARVHLFRTCAAVILRISTITMLSSSLFLSSSLISATHAWYLLPSPLEKRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D2L1</accession>
    <name>A0A812D2L1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_47617</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002593">
        <property type="protein sequence ID" value="CAE1289341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D2L1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1289341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="277" mass="30748" checksum="2E023EDBB1A5931A" modified="2021-09-29" version="1">MMLRCNRSMVLAGRDSIRISSNVASTNTVFFLGPCDMVFCLVFATPCFRKAILHRSIEGILALLEAASTISRTKLCLKVYQPFCSAFWQDDSIWRRFPYAPQNRQDHPQNTFSTPWTSFQVTGDSSKATSGAPGLNKTGITSAGTSLLASEYVLIRCLSSSSRSTLNVPRVFSLNNCFVKWKGLSVKDFWALVAFYFFLASCSALLNLPMCFLMPSRIELIFTALCSSLACIAARNLLSSMTGWFSAADFSCTAHFLQSKLYFPIVTDHVLKLADHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D4M0</accession>
    <name>A0A812D4M0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_45945</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002401">
        <property type="protein sequence ID" value="CAE1286358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6260718at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327">
        <property type="entry name" value="ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327:SF3">
        <property type="entry name" value="RNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="142"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="205"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="241"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="290"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="355"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="463"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="773"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="828"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="853"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="880"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="909"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="941"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="971"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1001"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1027"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1058"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1133"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1164"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1194"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1226"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1251"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1281"/>
            <end position="1301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="628"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="658"/>
            <end position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1286358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1302" mass="152933" checksum="9E7F9BD857A18E53" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D519</accession>
    <name>A0A812D519_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_47167</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002545">
        <property type="protein sequence ID" value="CAE1288558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D519"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="287"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1288558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="385" mass="46470" checksum="1A843E4F97D92509" modified="2021-09-29" version="1">MHHYFFLFSFIDHYFFILRIVLIFSLSFMLLKKSVFGEILPSFLPFFLSFFLSFFSVSFFFLLIFCLSFFFLFLCPYFLHCFPSFLFHKLFKLFTKSVLGNSFFSFFSFLLSILYHSFYLLLFLCFALFFFFSPFINLLDYLRNFLGNDFLPLPFFLSFFFLLFFLSFVIPSFFPLPFFFLLLPCCLFLPLTLFLLPFFLSFLPFFIPSSFLPSFFLSFFFFYYSFFHLFTLILLSFIFFLSVFLSAFFGFIFFFYHKPRFTLFFLSFFLTFFSPVLAVGYVFPHFFFYVCFMLFIYLSLEINFFLSFFSFFFLSFPINRFKSLISQSVSTAHLSQVPTHHISLLLCYKSRLPPPPPPLFLRPFHTTKHSFDLRHLYSHSLGDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D711</accession>
    <name>A0A812D711_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_47757</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002618">
        <property type="protein sequence ID" value="CAE1289638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D711"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1289638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="210" mass="22797" checksum="F319C888C64DA269" modified="2021-09-29" version="1">MVAMKQRYIRRFFFFHVLKLPIKINFDQHITIVPSNLSIYLSIYLSIYLSIYLSVCLSVCLSVGLRKPNSNCNFSSGLLLPVGLQLFCLPACNSSGLQRSLSLGATASFFFFVRGANPTLQLQLLSRRPPCNSSACPPCSSSACPPCNFFFFLPAATPTSLPKQLRLLLASSSSSSFSSSSFSSSSSSSSSSSSMSLVHSARVCFAIRAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D970</accession>
    <name>A0A812D970_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_47519</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002578">
        <property type="protein sequence ID" value="CAE1289142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D970"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1289142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="198" mass="23966" checksum="9579A9134E9D9051" modified="2021-09-29" version="1">MLKISVNNNNNNNNNNNSNNNYNIYLSIYLSIYLSIYLSIYLSKIHIVSFCLIHSYYSFFLSFFLSFFLSFFLSFFLSHSRIPSTCPEVLSLPYFYHLISFLLSSTLSITFEAIFFTFTSYRSFFFIIINFFLNTHHFNPIYSYPVFIFILIFSFNLSPLRSFHYYYPHLSQVILYFVSYKYPIFFFFDFFTIFHIFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DBB0</accession>
    <name>A0A812DBB0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_53165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003358">
        <property type="protein sequence ID" value="CAE1299308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DBB0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1299308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="168" mass="19206" checksum="9CCD5942C1AD9078" modified="2021-09-29" version="1">MATNLIHRETPKMEVYLSIYLSIYLSIYLSILTKVHSPPKANALFFASIYLSIYRKSIYLSLSLPLSLSLSFSLSLSIYIYSHPQTDCFAICSKSWGWHNTVFIAHVTRTITVVANKTNIIQPISSMTKSVHLQTCKIYKTYMIDLSIYLSIYLSIYLSIYPVIVVLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DBQ4</accession>
    <name>A0A812DBQ4_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heme-copper oxidase subunit III family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_53365</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003391">
        <property type="protein sequence ID" value="CAE1299639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DBQ4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000298">
        <property type="entry name" value="Cyt_c_oxidase-like_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039715">
        <property type="entry name" value="ZCCHC10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13491">
        <property type="entry name" value="ZCCHC10 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13491:SF0">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50253">
        <property type="entry name" value="COX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="325"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="365"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="430"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="463"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="495"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="529"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="578"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="617"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="650"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="677"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="719"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="750"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="782"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="domain" description="Heme-copper oxidase subunit III family profile" evidence="2">
        <location>
            <begin position="339"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1299639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="818" mass="94317" checksum="2D67DEBBF8F6E15D" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DCB6</accession>
    <name>A0A812DCB6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_49731</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002879">
        <property type="protein sequence ID" value="CAE1293300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DCB6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1293300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="229" mass="27372" checksum="F5AC6FD72D9A6B67" modified="2021-09-29" version="1">MYELNICNKLILSKSNALSLSLFLCLFFSVLNFFSFFLFSCLFSVSFSPSQMEFSFCLKKLFSFFLFLLLFLSFFLYFSFFFFLLLSFLSFLFSLSFFLLLSFFLSPSLFLSFSFSLSFFLLLSFFLSPSLFLSFSFSLSFFLLLSFFLSPSLFLSHYNGFQHNWYFGKVVYLVNGSNGPKSPLYYRYYHRLIYFLNNFYHFQILLKDRVGFLMKSYWSIDAFHRLKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DCK9</accession>
    <name>A0A812DCK9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_50489</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002977">
        <property type="protein sequence ID" value="CAE1294587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DCK9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032501057" evidence="2">
        <location>
            <begin position="24"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1294587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="245" mass="27539" checksum="6628CDE540E69C3D" modified="2021-09-29" version="1">MRVSTKNLLSLLIFLFRIPSFLYHSCFSFSPLCYSIAYPLSSSSSSSSSSSSSSSFLSHPFPFYFSLSLVSILLFLILVSPSLLFSPILFLIHFFSFYLSHSLLSLSYLFLIISRIPSSRSHSCISSSSYSLSIYLFISIYLSPLLSLSVSYHLSLFLILYYPFPISFSFSLVSPFLFLILLFFSFSSHFLNSSLSSLTFSFPLPLPTLPSPTCFSINFPLAFSLSCLLSIIILHFFFFSSCSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DDG8</accession>
    <name>A0A812DDG8_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Copper transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SPHA_53857</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003443">
        <property type="protein sequence ID" value="CAE1300458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DDG8"/>
    <dbReference type="OrthoDB" id="6158546at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483:SF115">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="4" id="KW-0187">Copper transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAE1300458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="214" mass="24339" checksum="90209F316ED8B5BB" modified="2021-09-29" version="1">MIFLEVLISDSPLDRLTATAVSLSLSLSLSLSLSLSLSLSLIIFTLRTTADFIIKGWHIDSYFGLSITILLIIIIGMVFEGFQSFRFVHFMARAERYRRCCSSPKKQRALALRTHLERSFLHMFQVLVGYMLMLCAMSYNVWIMISVVLGAGLGYFFLRPVVLHWLEQRKKNREKGKEKWSELKVQFLNGVNVKAESKGCQSAKIDGEKAETCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DHK5</accession>
    <name>A0A812DHK5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_52407</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003254">
        <property type="protein sequence ID" value="CAE1298084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DHK5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1298084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="182" mass="21256" checksum="00C8916321DE6E8C" modified="2021-09-29" version="1">MSLHSFLTLAMSLYPFLTPATSLYPFVTPATIVSYDIPVLSLILSIYLSIYVCHGLFIYISIYPFRSFHIYLSIYLSIYLSIYLSHNTIYLSIYLSIYLSIYLSLFIIYLSIYLSIYLSISVCSLSIYLSIYLSIYLCQSVNYLSVNLYVCESIYLSIYLSIYLSIYLSLSLYIYIYFQSMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DJ15</accession>
    <name>A0A812DJ15_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_53881</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003443">
        <property type="protein sequence ID" value="CAE1300445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DJ15"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="328"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="355"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="422"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="464"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="492"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="525"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1300445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="550" mass="68399" checksum="C0B38A05C5B3EDD3" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DJM9</accession>
    <name>A0A812DJM9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_54885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003625">
        <property type="protein sequence ID" value="CAE1302274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DJM9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1302274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="263" mass="31683" checksum="C6BBB18AB150BE9F" modified="2021-09-29" version="1">MFFYSFYHYFTPIIALFIRFYHFCSPIPLLSALLTLQFFLSFLSFYLSLLIFPFFLSFLVFHFFFSFFLSFFLSFFLSFFLSFFLSFSFLSFFLIFSFFLSFFLSYFVSFFLSLKKVYSPAGIKCASAYLSKFKISIYLSIYLSIYLSIEIQISIYLSIYLSIYLSIYLSIEIQISIYLSIYLSIYLSKFKYLSIEIQISIYLYIYLNSNIYLSKFKYLSIYRNSNIYLSIYLSIYLSIYLSIYLSIEIQISIYLLKFKYLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DM93</accession>
    <name>A0A812DM93_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RSF1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_54335</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003529">
        <property type="protein sequence ID" value="CAE1301324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DM93"/>
    <dbReference type="OrthoDB" id="6152395at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15517">
        <property type="entry name" value="PHD_TCF19_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="464"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1301324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="857" mass="95465" checksum="8C56F7F58F0E9E47" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DWI0</accession>
    <name>A0A812DWI0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_60374</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004198">
        <property type="protein sequence ID" value="CAE1308525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DWI0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="317"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="374"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1308525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="397" mass="47512" checksum="4AAFD0DF3FFFB916" modified="2021-09-29" version="1">MSEQMITFWNVRDSSHSTHFFLFSFFLSFFLSFDASFVSIYLSIYLSIYLSIYAIFVSIYGIFLSIYLSIYLSIYLSIYDISYLSMRFHLSIIYLSIYLSIYLYVSRSLSIYIHLSCHFNMSIYHILSISVCLSIYLSSPISGYSSIYAILKFHFSVYLSIYLSIYLSQNVHYLFHLSIYLSIYLSMTFHISIYLSVYLSIYLSIYRISIYLSIYLSIYLWHFSIYLSIYLSIYLSIYVSPFIIYLSLFIYLCHFKYAIFVSIYLRMYIIYFSLFIYLSISLFITYLRIFIYLCHFKYSIFLSIYLSIYLSIYLRMFITYFTLSIYLSIYLSIYLSMTFSYLPISIYLSIYLSIYLSIYLSVHLYLSIYLSIYLSIYLSIYLCSYEIPIAITLVIAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DXK1</accession>
    <name>A0A812DXK1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_63347</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004540">
        <property type="protein sequence ID" value="CAE1312071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DXK1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1312071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="153" mass="18772" checksum="819AD3034A7074A9" modified="2021-09-29" version="1">MPAINFFSLTVCEMCSQFNTTVNHLFLQYHLLCFYFSFFLLPFFLSFIAIISLFVLFYHFFFFSIILPLCFLPIIFFSFITFISLFSSTVVFFTFFNLLFYHLFHYHSYFLLYYSFSFFFFFSLSILTNLFLSFLFLFCYHFLLLLRFLFLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E294</accession>
    <name>A0A812E294_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_63034</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004519">
        <property type="protein sequence ID" value="CAE1311691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E294"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1311691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="298" mass="36158" checksum="69B32A069F2F3CC0" modified="2021-09-29" version="1">MIRLFVSFFAKIIKKKILGTVFLSFFFFFFHARSFLLRFFSSFFSLFSFLFSFSFSRFSFFLSFFLSFFLSFFILCSFFLFLSNISLIFTFNFFFTFFLFFFGSVFSFLLFIFFLFFWSPSIVFFLLFFCLFFFLCSFFFHPFLFFFLCIHPFIFCRLFFVSFFVSFFAFILSFFLPLHSSFLSFFLSFFLCSSLLFVSYSSDLSLPFIVSFFLSLLLFVCFFLSFFLSFFLSFYAPLCCLFLTSLIFLSLLFFLSFFLSFFFPFYSFFLSFFLSFFLSFFLSFFLSMLLSVVCFLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E404</accession>
    <name>A0A812E404_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zinc finger PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_65206</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004700">
        <property type="protein sequence ID" value="CAE1314219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E404"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15489">
        <property type="entry name" value="PHD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1314219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="173" mass="19155" checksum="12A3A1D8E87DB222" modified="2021-09-29" version="1">MSLPSSLLECDRCFSCGSINKRKSIRICSNYQRSFHLSCVGLTRKASASLVVWNCSYCLSLSALQDSVIHQPNEPSQRDTSEVLRATLLLRQFRKVPLKIPKSVRIPAADALATAIDQALNLNSSLDRDHLFSFATIVLGIPYNKDPTSSVSSILKNNISLFNSSKINATEFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E455</accession>
    <name>A0A812E455_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_65948</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004744">
        <property type="protein sequence ID" value="CAE1314940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E455"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="313"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="389"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="420"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1314940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="440" mass="52125" checksum="04AC4E0F986116AA" modified="2021-09-29" version="1">MLEWLFYYSTGHKDDDLFSIYLSIYLSTFSSLSSLISSIYLSIYLCSVSSDFSFNLSIYLSIYLSIYVQFSLIFNFFDLSIYLSIYVQFPLIFHLIYLSIYLSIYLSIYLSLFISSHFSFNLSIYLSIYLSIYLSISVQFPLIFHLIYLSIYLSIYLSIYLISIYLSIYLSMFISSHFSFNLSIYLSIYLSIYLSISYLSIYLSIYLSIYLSIYVQFPLIFHLIYLSIYISIYISIYLSSLVQIYLFAYLAPFFFPKHNFAVILRPKRSSLFKCLLLQAISMLPANVIYSMVTPHTHLVFVNWILTQTDFSDLYPFLIFFFFFFFFFFFFFFKLLNSFGYFLCTMVFLTRLFFCRFLLSFLSLFLDLMVPISFDLFRFRASFIINSQSISLSLSLSISLFLSLLLFILSFSFSYRCSLSLSLSLPIVFLSFYFCLSHYII</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E666</accession>
    <name>A0A812E666_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">KRAB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SPHA_68544</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004991">
        <property type="protein sequence ID" value="CAE1318044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E666"/>
    <dbReference type="OrthoDB" id="6591996at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Zgc:162936"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002349">
        <property type="entry name" value="Zinc finger and BTB domain-containing 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000145">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Classic Zinc Finger"/>
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    </dbReference>
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        <property type="entry name" value="Ikaros_C2H2-ZF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404:SF114">
        <property type="entry name" value="KLUMPFUSS, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
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    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="170"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
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            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
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            <end position="253"/>
        </location>
    </feature>
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            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
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            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
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            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="30"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="50"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="116"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAE1318044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="336" mass="38753" checksum="89EDA982B6766495" modified="2021-09-29" version="1">MQFSQQSNHGLQLQVGEQVFPETISQYHHHKQNLPQNHHRHNLRGHSKQFDANSNNYASTNSRNNSKLKHPVLPPSSSPGSSTATPQGVLSQAHMSSSSTQKSAHMHNNGDGPAKNSPSRLSQPTLSINTDSNLNINADLLNASPLNSKQFYVRKNVHDQNQANIRKKPFRCPICGNPFLRRRTMEVHEKTHSGIRPFSCSYCPQRFFQKDKLLIHERTHTGERPFECNICSKQFARKDTLNIHRRMHSGERPYPCEHCHKRFAQRDKLLIHERTHSGEKPYQCLICSKQFARKDTLNVHHRTHTGEQPYRCDNCGKRFSQRDKLALHKWKCNNNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E769</accession>
    <name>A0A812E769_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_67612</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004896">
        <property type="protein sequence ID" value="CAE1316995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E769"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="179"/>
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    </feature>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="351"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="396"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="431"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="472"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="573"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="596"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="629"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1316995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="659" mass="76092" checksum="4AD38CCE1220D7A3" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E7F0</accession>
    <name>A0A812E7F0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_67052</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004841">
        <property type="protein sequence ID" value="CAE1316288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E7F0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1316288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="290" mass="34283" checksum="973B5057D9480C37" modified="2021-09-29" version="1">MEDKLRLTGLISPPLSLCLSFSLSLFLSLSLSVLSLSLKIAVLQIHFSSNLSFRFFSLFLFVLSFLKIYFVIFTVLTALSVPISLSFPLFIYVFFYRLFYLASLFFLASICFNLSLFFSSRSYDTLHCFFFFLFFVSYRSYYALFLASFPSIFLCYYTLFHFPFPPFSFLSYYSLSFFISFFSFLFYYPNSSLSSLLSCSLFAFITPALSITFPFFLFSLTTPSLIHFFLLFCTYYSLFSFLFHSYYTLCFFLSFFSYRLIIPYYAFFSFLILFSLITRSLFPFFFSFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E944</accession>
    <name>A0A812E944_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondrial cardiolipin hydrolase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Mitochondrial phospholipase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SPHA_67941</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Farmed</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the phospholipase D family. MitoPLD/Zucchini subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004929">
        <property type="protein sequence ID" value="CAE1317365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E944"/>
    <dbReference type="OrthoDB" id="5205528at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016891">
        <property type="term" value="F:RNA endonuclease activity producing 5'-phosphomonoesters, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034587">
        <property type="term" value="P:piRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051406">
        <property type="entry name" value="PLD_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43856">
        <property type="entry name" value="CARDIOLIPIN HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43856:SF1">
        <property type="entry name" value="MITOCHONDRIAL CARDIOLIPIN HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipase D-like" evidence="8">
        <location>
            <begin position="93"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00043167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAE1317365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="221" mass="24982" checksum="5040DEDC3D98D95D" modified="2021-09-29" version="1">MPSMVSFFLGAITSGVVFGALYTTYGYAIKKLRSKKGSNDDDGSSDVEETFTDILMFPDISIACKDNFILDTGCIRPKCRQSHEKTSLSEIYRHLCNAKLSICVCVFHITYSDLAEVLIAMHKKGVQVKVITDDENVNEESQVAKLKDNGIVVRTDNSSSFMHHKFTVIDHQIVIHGGSQGNYRCRIRKRQQLTYLETSKLRDSSAHRQFTLLYAPQVCYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E982</accession>
    <name>A0A812E982_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_68410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004979">
        <property type="protein sequence ID" value="CAE1317879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E982"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1317879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="197" mass="23561" checksum="810ACC5C225CEECF" modified="2021-09-29" version="1">MHIFFFLFFSFFLSIYLSIYLSIYLSIYLSIYNLGPFLLSIYLSVYEFGHIYLSIYLSIYLSIYLFVHIYLCMYVCMYLSIYLSIYIYMSLSTSIYLSIYLSIYLSIYLSIYLCINWCISIYLSIYLSIYLSIAVFSYPSILLYISGHIYLSKKFFTIRSINKLSQTTQDNLMYIHSIILSIYLSIYLSIYLCRAYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EAQ1</accession>
    <name>A0A812EAQ1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_71437</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005233">
        <property type="protein sequence ID" value="CAE1321337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EAQ1"/>
    <dbReference type="OrthoDB" id="9635126at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134:SF22">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134">
        <property type="entry name" value="OS08G0543275 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="311"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="339"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="387"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="415"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="442"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1321337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="462" mass="55067" checksum="D0207C83449F13C4" modified="2021-09-29" version="1">MDVRKLLLWFLFLFCSVYSNLSIYLSIYLSIYLSIYLSLYLSQSLHIYLSIYVYSNLSIYLSFFISIYVYSNLSIYLSIYLSIYLSIYLSIYLSIYLSLFISIYVYSNLSIYLSIYLCMFIQIYVYSNLSMYVYSNLCLFKSIYLSIYLSIYLSIYLSISVSSYLSIYLCLFKSIYLSQSLHIYLCLFKSIYLSQSLHIYLSIYVYSNLSIYLSLFISIYLCLFKSIYLSIYLSIYLSIYLSQSLHIYLCLFKSIYLSIYLSIYLSIYLSQSLHIYLCLFKSIYLSIYVYSNLCLFKSIYVCLFKSMSIQIYLSIYLSIYLSIYLCMFIQIYVYSNLSIYLSIYLSIYLSIYLCMFIQIYVSIYLCLFKSMSIQIYLCQFKSIYLSIYLSIYLSIYLSISYCLFLFIPIFRPLPLFLYLSIYLSIYLSIYLSIYLYASSLALFKSIYLSIYLSIYLSIYLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EAR8</accession>
    <name>A0A812EAR8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_70954</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005198">
        <property type="protein sequence ID" value="CAE1320755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EAR8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1320755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="206" mass="25148" checksum="7A18C3B720ABB034" modified="2021-09-29" version="1">MRIFLFLSFFLSFFLSFFLSFPFFFIDHLFIRLSFYSFLKTSLFVCLFVCLFLSFFLHWLNLSLSFFLSFFLSFFLSFFLSSFHSSFLSYFLSFFLSLTLNIYLSIYLSSFPLSFINPIIFSYYQTIFFFIGFLFLFMLFKHLSFFLSFFLSFFLSFFLHWLDFSLLSFFLSSLAESFSSFFLSFFLEQFFMSSFQALFYHYSRQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EBJ2</accession>
    <name>A0A812EBJ2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_69662</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005098">
        <property type="protein sequence ID" value="CAE1319225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EBJ2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="229"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1319225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="302" mass="35763" checksum="8A35EC2AD4452412" modified="2021-09-29" version="1">MSIKSYWDDISKTIYCSLLKDECYDRRNHHCYFRRLSLHRYFFLFIFLFCLFLFIFPRRSGDIPPDFLRGFLLLLFIYSFLSVFLDIARSHLPFFLSSLLISFFFLVFLILFLSLSLSLSLFVSLIFLVSLFSFILLSNIPLITFSSCILIFFLFSSSHFFTYSSYIPFISSVCLFFLLHFFSSIYFSSVFPHSFLHPPFLHFIFLIIYPFTFILSPIFFFFFLNPCSLFLLFLLPSILNSSSSLIPRTFSLFFSLSDTFPFFTVSIVPFFRFFQFRCPHPPHHHSKSDLRASTTSNIISSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EDJ4</accession>
    <name>A0A812EDJ4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_71573</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005241">
        <property type="protein sequence ID" value="CAE1321476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EDJ4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="101"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1321476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="164" mass="18338" checksum="42AEFB392935A086" modified="2021-09-29" version="1">MHDVSYLSIYYILLTSNYLSIYLSQSLLSIYRYSLYKCLIQVISIYLSIYLSIYLSIYLSIYLNYPSIISPRPLHSLPNGPADSEAASYNREGQRNHPNISSSSSSSSSSSSSSSSSSFLFISFYSSYLSAYLSFLFSLTPFLNTSPIASLAFFFPLPLFLSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EH01</accession>
    <name>A0A812EH01_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">E3.2.1.14</fullName>
            <ecNumber evidence="7">3.2.1.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SPHA_75274</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Farmed</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="7"/>
    <dbReference type="EMBL" id="CAHIKZ030005454">
        <property type="protein sequence ID" value="CAE1325565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EH01"/>
    <dbReference type="OrthoDB" id="76388at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF248">
        <property type="entry name" value="CHITOTRIOSIDASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="6">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAE1325565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="158" mass="18885" checksum="C5BC91A5FD0DDC46" modified="2021-09-29" version="1">MYKQFTRLKKKNPNAKTLLAVGGWSMASQPFTAMVRSKESRRDFIIHAIRYLRTHNFDGLDLDWEYPANRGSPPEDKQRFVELVKSFFLSVRLCFFLLPFFFFLSFFLSFFIFYLILSVFLSFYFLSFFLSLFLSFFLSFFLRTCSCSSSVFTYLIIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EM89</accession>
    <name>A0A812EM89_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_73510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005380">
        <property type="protein sequence ID" value="CAE1323585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EM89"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="305"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1323585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="325" mass="38256" checksum="0695CB636F057411" modified="2021-09-29" version="1">MHGYMGAYAAFGQTEVRSSRENHQERHVGNCNSHIPEINSMFDSLIKVCTLFHRHLFIPTHFSFHFIYSFPLISLSPPFILSTSFFFPLHLFFPTHFSFPFIFLSLSFFLHFIYSITLIFLSALFPPLILLSASFSPLIFLSHSFFFPLIFYPLHLFFPPHFSFPLIFLYTSFILSPSFFFPTHFSIHFIYSFPLIILSTSFILSHSFFFPLHFSFPLIFITSSFFLSPSFFFPLHLFFPLIFPSTSFILSLTLFFPLHLFFPTHFSFHFIYSFPLIFLSPSFFFPPHFSYTSFNLFPSFFSASFPPLIFLFLSFFFSTSFILSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ETJ4</accession>
    <name>A0A812ETJ4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_78964</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005555">
        <property type="protein sequence ID" value="CAE1329546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ETJ4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="284"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="339"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="460"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="490"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="519"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="549"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1329546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="570" mass="65845" checksum="8830461F0E0FC95D" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EU87</accession>
    <name>A0A812EU87_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">EMX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SPHA_79398</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005566">
        <property type="protein sequence ID" value="CAE1330018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EU87"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007420">
        <property type="term" value="P:brain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000081">
        <property type="entry name" value="Empty spiracles homeobox 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050877">
        <property type="entry name" value="EMX-VAX-Noto_Homeobox_TFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24339:SF28">
        <property type="entry name" value="E5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24339">
        <property type="entry name" value="HOMEOBOX PROTEIN EMX-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="208"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="231"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="272"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="333"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="375"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="409"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="434"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="463"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="486"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="518"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="543"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="98"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="100"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="157"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="165"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAE1330018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="568" mass="67616" checksum="453519D8ABA9C076" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EUX7</accession>
    <name>A0A812EUX7_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Otopetrin-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SPHA_81348</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the otopetrin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005631">
        <property type="protein sequence ID" value="CAE1332313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EUX7"/>
    <dbReference type="OrthoDB" id="6429739at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015252">
        <property type="term" value="F:proton channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004878">
        <property type="entry name" value="Otopetrin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21522:SF32">
        <property type="entry name" value="OTOPETRIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21522">
        <property type="entry name" value="PROTON CHANNEL OTOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03189">
        <property type="entry name" value="Otopetrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="393"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="427"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="468"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="500"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="539"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="570"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="269"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAE1332313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="611" mass="69423" checksum="D0A75E4F91F0F228" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EXK2</accession>
    <name>A0A812EXK2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_81250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005628">
        <property type="protein sequence ID" value="CAE1332166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EXK2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="307"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1332166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="328" mass="38647" checksum="3A193A3C7617590B" modified="2021-09-29" version="1">MLINGPASLSPVQRTVFLENPVALALILLFYLSPAILSTFKLNSTAMASLSSGEGYFVSNLLSSFFLSFFLSFFLSFFLSFAILILIYCLLSFFLSFFLSFFRLFFLHFSFFLSFFLCLDSNRLSFIYFLCFFLCFILCLFVSLFVSLFVSLFHTLFVCLFLCFFLFCFILCLFVCLFVSLFLSLFHTLFLCLFVCLFVCFFVCFFVSFFVSYFVCLFVCLFLSFFVSYFVCLFVCFFISFFVSFFVSYFVSLFVCFFLCFFVCFFVSFFVSYFVCFFVSLFLSLFHTLFVCLFLRPMHILYASLNLRRLHISFVFLYFMLTASSFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EXY2</accession>
    <name>A0A812EXY2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_81466</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005633">
        <property type="protein sequence ID" value="CAE1332409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EXY2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1332409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="290" mass="34216" checksum="706BC8A998487096" modified="2021-09-29" version="1">MFQDIPSYLSIYIVLSSYLFNSFYSYLSIYLSIYLSIYLSHSVLIYLSIYLSIYLSTKVCLWMTISIYLSIYLLLSLHLSIYLSIYLSIYLSIYLFMALRYIYLSIYLSIYLSMAPDVCLIINIYNIYLSIYIYLSIYGTSILLNHYNNNNLSIYLSIYLSIAPRYYNNNNLSIYLSIYLSIYLSTMSSISIYPIFSHLRLLNHYHLSIYLSIYLSMAPRCLLLNHYNNNNLSIYLSIYLSMAPRCLLLNHYNNNNLSIYLSIYLSIYGTSILLNHYNNNNLSIYLSIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EYD8</accession>
    <name>A0A812EYD8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_79981</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005586">
        <property type="protein sequence ID" value="CAE1330709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EYD8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1330709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="168" mass="18579" checksum="F5ECE4202A385990" modified="2021-09-29" version="1">MLLKISSRFLYFAIFSSFPFTASRFLSPTSIPHSLSLTLSFSLPIDSFLVRSFSLSLSLSLSLSHSLSILFCYSSLSLSFGFSFSLSLSLSLSLSLSLTHTHTHILYGFSSVSSLSISFSSYVDSLFFLLCLSLTFCINSLLFPTFSFSVHSLPLFPPFLSLSFSFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EYK5</accession>
    <name>A0A812EYK5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_79511</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005570">
        <property type="protein sequence ID" value="CAE1330152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EYK5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032945639" evidence="2">
        <location>
            <begin position="21"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="301"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="337"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1330152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="395" mass="44454" checksum="BA67AB1C91E9EC80" modified="2021-09-29" version="1">MNFFPSFFAIFLSLFHSFFTNLLSPSLPSFAFSHACFNLFPSYTFFHNFSFTLSVDFSTDLACFLLLNSFTLFPLFSFLCTVSLALSPLHSFLYPLSFVLFSSPSLLHTPSFALFPSPSFLSSLSFTLFPSPSFLCSLPFALFPSPSLLHPLSFTLFPSPSFLSSLSFALFPSHSFLHPLSFTLLPLPSFLCSLPFALFPSHSFLHPLSFTLFPSPSFLYPLSFLLFPSPSLLHPLSFTLLPLPSFLCSLPFALFPSPSLLHTPSFTLFPLFSSLRTLSFTLSPLHSFLCNSFLHTLFLPFFPLLSIILLSFTFFVILFFILILLQVIFQTFLPFTFLNFFPSSLTFSLSSCLFLCLPLFVFLPLFFMSLSISLCFSSSLFHVSLSPPTLFSFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AJ05</accession>
    <name>A0A812AJ05_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_1174</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000032">
        <property type="protein sequence ID" value="CAE1142980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AJ05"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="354"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="388"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1142980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="432" mass="52130" checksum="DECD0CB7DC351900" modified="2021-09-29" version="1">MASFFSLTFLFYFYLSYYLTRFRSSRFPSLAFFLSVSFLSFPMSFFFSFSFLFSFPFFYYLLSLCYFLLFLSSLLFLSFNLILHFSFPFLSFFLSPFYHFLPRFCVFLFFPLPLSFSFPIFSYFFRFPLFPLPLVFFFLSFFLSFFLSFFLSFYLLFYHFLPRFCVFLFFTLSLSFSFPIFYFFRFPLFPLPLVFFFLSFFLFISFLSFSPSILCFFSSHFHYLFRFLSSSISFFFPFSLFPWSFLSFFLSFFLSFFLSFFSSFFLSSFLSLFRFLSRSFRFIRRYLFSLSLSHSLLSLSYSFLSSVSVIISFYFLIFLYLLLFTIFLSLSLSLLSLSFSSTLSLFLTSPLPSFLLSLILLSLFLFSFSLFYLSLSFITFSIVSLSSFLFYICFSFLSFFLSFFLSFFLFFFLHICFFLYLSMLREHTDGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ALA2</accession>
    <name>A0A812ALA2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_227</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000002">
        <property type="protein sequence ID" value="CAE1138286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ALA2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1138286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="268" mass="31692" checksum="7DE55B5FF7C876EB" modified="2021-09-29" version="1">MTTTANCYVWPSCHDCSASVSLSSSQFGVQQCPLQVQAALACHRAHQVQCQQCLGTTHFHKSFHFIKIQLFFFFFFFFFFSSSLFSPLLLPYTFSSFFFLPSSFSSSSSSFIFLYLFSFFLRFLLLLLPDPYSSSFSSSSHFCFLFFLLFSSSSFFFLLFFLLPSSSSIFFFLFFLFLPSSFFPLLPFFFFFFFLSFYSSFFFFLVLFLFLLIILFLLPFCLLFLILLHLLSSFPPSSYYFSFFFLHIFFFFFFFLLLLLLLLLLLLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AMG1</accession>
    <name>A0A812AMG1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_2112</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000060">
        <property type="protein sequence ID" value="CAE1147484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AMG1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1147484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="344" mass="41906" checksum="01A0F28FE10FC771" modified="2021-09-29" version="1">MLFSFFHSFFLSFFLSSCYVIFFLFSSFLLYYFLSFFLSFFCAMLFSFFFFLSFFLSFFLSFMLCYFLSFFFLAMLFSFFFLSFLCYIFFFFPFFLFSFFLSCYVIFFLFSFFSYYFLSFFLSFLFYVIFFLSFFFSFFLFLSFMLCYFLSFFFFLAILFSFLLSFFLLCYVIFFLSFFLSFFLSFFHAMLFSFFFLLSCYIIFFPSFFLSFVLCYFLSFILSFYVIFLSFVLSFFLLLFLLLIYFFIISVSLSFFSLSLQVKHWVTSPITQQIVFFLPLTVHIFLSTCLCSSIYFSLIRSIYLSIYLSIYLSISLIISTFLSQSNHVYLSIYLSNHIYLSISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812APF4</accession>
    <name>A0A812APF4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PATL1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SPHA_3042</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">P-body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PAT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000089">
        <property type="protein sequence ID" value="CAE1150933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812APF4"/>
    <dbReference type="OrthoDB" id="74835at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033962">
        <property type="term" value="P:P-body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039900">
        <property type="entry name" value="Pat1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019167">
        <property type="entry name" value="PAT1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21551:SF0">
        <property type="entry name" value="PROTEIN ASSOCIATED WITH TOPO II RELATED-1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21551">
        <property type="entry name" value="TOPOISOMERASE II-ASSOCIATED PROTEIN PAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09770">
        <property type="entry name" value="PAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="mRNA decay factor PAT1" evidence="8">
        <location>
            <begin position="582"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="29"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="292"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="299"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAE1150933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="874" mass="97708" checksum="F994902A893EF518" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AQI0</accession>
    <name>A0A812AQI0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_2088</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000059">
        <property type="protein sequence ID" value="CAE1147400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AQI0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="26"/>
            <end position="47"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1147400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="191" mass="21947" checksum="8F5F18CF7D9BA11D" modified="2021-09-29" version="1">MLLWAQHGLLPPPSILLRELPCPSSLVFTLFTYCIYNFLIHCIYLSLIHCIYSSSSPSLYLFLSHSLSIPLYFFLSSLLYLLIYVSPPYLLIHVSPSVFINLSLFSTLSISLSSPPHYLLFSHSLSFYLFFTCSLSNFIYFSLSLPHFIHFSLFLSLSVSLILFIFLSLVLSPSHYIHFLSLFLFIFLSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ARL9</accession>
    <name>A0A812ARL9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_5486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000181">
        <property type="protein sequence ID" value="CAE1157956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ARL9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="286"/>
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        </location>
    </feature>
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    </feature>
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        <location>
            <begin position="338"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="375"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="442"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1157956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="468" mass="54866" checksum="ED530CC4857DBAF8" modified="2021-09-29" version="1">MMIEFVFIESESIFKSTIFKYTLSWITYIYYLSIYLSIYLIYLNLFIIHHLSIYLSIYLSISVCSLSIYLSIYLSIYLSITHSSLSIYHTLLSIYLSIYLSIYLSIYLSQSAHYLSIYLSIYLSIYLSIYLSICSLSIYLSIYLSIYLSIYLGMFIIYLSIYLSIYLSIYVHYLSIASIYLSIYLNLFIIYLFVVSLLSIYLSIYPIYLIYLSIYLSIYLSIYLSIYLSLFLSIYLSIYLSIYHTLLSIYLSITVHYLFAPLFSFFLPSVHPSFLPSFLPSFLPSIPFFLSFFLSSFICSCLTFFFSFLLHLYFLSSFLSSFLSFFFVPRGHSYTSPLFILSFIFFFFLSFFLSFFVRSFFFFLPSFLARRSNFYSTLVFILALKLCFLSISILSSLYTRSLSLFLSLSLSLSLTHTNTYTLTCVQNYIYACKCSSFPCVHIYLSIYLSIYLSIYLSVCLSATQIFPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ATM4</accession>
    <name>A0A812ATM4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_4059</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000124">
        <property type="protein sequence ID" value="CAE1153890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ATM4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="268"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="304"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="358"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="382"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="416"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="449"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="481"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="505"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="534"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="562"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1153890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="584" mass="67201" checksum="A9E8FA6D6715BB66" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AU24</accession>
    <name>A0A812AU24_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_3842</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000115">
        <property type="protein sequence ID" value="CAE1153395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AU24"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="372"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="411"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="486"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="539"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="568"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="665"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="697"/>
            <end position="721"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1153395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="730" mass="82873" checksum="AB27C5C1D7ED3D07" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AV68</accession>
    <name>A0A812AV68_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_4788</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000156">
        <property type="protein sequence ID" value="CAE1156457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AV68"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134:SF22">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134">
        <property type="entry name" value="OS08G0543275 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="326"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="356"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="392"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="417"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="452"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="491"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1156457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="528" mass="61961" checksum="C20F725255443698" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AVW0</accession>
    <name>A0A812AVW0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_5626</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000185">
        <property type="protein sequence ID" value="CAE1158594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AVW0"/>
    <dbReference type="OrthoDB" id="10046650at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35313">
        <property type="entry name" value="NO EXINE FORMATION 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35313:SF1">
        <property type="entry name" value="NO EXINE FORMATION 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="303"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="333"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="357"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="381"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="411"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="444"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="477"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="515"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="575"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="606"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="646"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="686"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1158594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="686" mass="76753" checksum="9FAFAD0ED7395433" modified="2021-09-29" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AW14</accession>
    <name>A0A812AW14_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HSPA1s</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SPHA_5321</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Farmed</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000178">
        <property type="protein sequence ID" value="CAE1157631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AW14"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10233">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000172">
        <property type="entry name" value="Heat shock 70 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000001">
        <property type="entry name" value="heat shock 70 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000026">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAE1157631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="611" mass="68115" checksum="826081404108A6AC" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AX75</accession>
    <name>A0A812AX75_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_8610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000280">
        <property type="protein sequence ID" value="CAE1165825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AX75"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1165825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="211" mass="24652" checksum="701B4BAF5081F95D" modified="2021-09-29" version="1">MHSTNIYLSIYLSMHVNIYVNISLSQSLNIYLSIYLSQLISIYLSIYLSIYLSIYLSLLISMLISVYICYLSIYLSIYLSIYLSMHVNIYVNISLSQSLNIYLSIYLSIYLSMIFECTTTNIYGFLSIYLSIYLSIYLSHLLIISLYLSISLSLYIYIKQSVNYLSIYLSIYLSIYLSIYLCVQKLIWQLLCSLSLSYLSIYLSIYLHTLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AY56</accession>
    <name>A0A812AY56_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TRAPPC8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_6517</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000213">
        <property type="protein sequence ID" value="CAE1160625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AY56"/>
    <dbReference type="OrthoDB" id="203724at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990072">
        <property type="term" value="C:TRAPPIII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024420">
        <property type="entry name" value="TRAPP_III_complex_Trs85"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12975:SF6">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12975">
        <property type="entry name" value="TRANSPORT PROTEIN TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12739">
        <property type="entry name" value="TRAPPC-Trs85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1160625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="256" mass="29716" checksum="2E1B24B5E3542CAA" modified="2021-09-29" version="1">MLSNSSIYSISLTQLSQPVISFSPFFFFFFSLFPPFFLYSPFFSSPFSPLFPFFSLFPFFFILFFSLFPFFSLFPFFSLFPFFLFPIPPFSLFFSFLPFPPHIRDPNNVPHSMHNLKITVKDLNTPPPQQAVARKMMTDTVASAQPQLMDGNQRNVITIGDYDLQLSATTPWFEAYRECFLHLLPPSDHEFLNHCLACMFVVSSGHTDPLGVFNTLSQQQSQQHNQFPNKLPKWFCPNILKYYVLLHDVVEGEQAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B1Q8</accession>
    <name>A0A812B1Q8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DYNC1I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SPHA_9067</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein intermediate chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000291">
        <property type="protein sequence ID" value="CAE1166779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B1Q8"/>
    <dbReference type="OrthoDB" id="4189at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045503">
        <property type="term" value="F:dynein light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010970">
        <property type="term" value="P:transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000781">
        <property type="entry name" value="Cytoplasmic dynein intermediate chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025956">
        <property type="entry name" value="DYNC1I1/DYNC1I2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050687">
        <property type="entry name" value="Dynein_IC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442:SF22">
        <property type="entry name" value="CYTOPLASMIC DYNEIN 1 INTERMEDIATE CHAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442">
        <property type="entry name" value="DYNEIN INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11540">
        <property type="entry name" value="Dynein_IC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="104"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="112"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="148"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAE1166779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="638" mass="71773" checksum="0EF3036DEBD4811C" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B2Y2</accession>
    <name>A0A812B2Y2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_9561</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000305">
        <property type="protein sequence ID" value="CAE1167713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B2Y2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1167713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="187" mass="19991" checksum="4336A297B6679016" modified="2021-09-29" version="1">MPAASPLLLYEPSYLDARDFAAVFSRPRKQPVLRSSRPSPAADGTQHHQQQLFKQSFSGLTSESHSITTLRGPTRFTLCYCLPSETPAHSCSFQPTPAAFSTPAASSSLLQLPALLQLSAHSCSFQHSCSLQLTPAASSTPAASSSLQLTPTASSSLLQLPALLQFPAHPCGALLTSRYLFQHPLTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B4G3</accession>
    <name>A0A812B4G3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_11257</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000372">
        <property type="protein sequence ID" value="CAE1170797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B4G3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1170797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="205" mass="24721" checksum="6BE9B2F8A8AD4416" modified="2021-09-29" version="1">MVVSLLKDQITSRYRSQLFHIYLSIYLSHLSFLLLLHYFLLLQFFILLLLHYLFFFFVVVVVFFFFFFFFFFFFFFFSSFTCSSSSSSTSTCSSFTSSSSSFSLVRIYLSIYLSIYLSIYLSQSVYYLSHSVHTYLSIYQFYSVHIYLSIYLSHSVHIYLHFFLIYIYLSIYLSIYLSIYLSIYVIPFISIYLSIYLSIYLFISY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B6J5</accession>
    <name>A0A812B6J5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_12341</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000413">
        <property type="protein sequence ID" value="CAE1172952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B6J5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="422"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="449"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="488"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="521"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="544"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="606"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1172952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="648" mass="76866" checksum="3368C60F856E36E2" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B979</accession>
    <name>A0A812B979_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="16">ITGA4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SPHA_13191</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Membrane</location>
            <topology evidence="1 13">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the integrin alpha chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000441">
        <property type="protein sequence ID" value="CAE1174645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B979"/>
    <dbReference type="OrthoDB" id="5317514at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008305">
        <property type="term" value="C:integrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033627">
        <property type="term" value="P:cell adhesion mediated by integrin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.930">
        <property type="entry name" value="Bicelle-embedded integrin alpha(iib) transmembrane segment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1460">
        <property type="entry name" value="Integrin domains. Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1510">
        <property type="entry name" value="ntegrin, alpha v. Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1530">
        <property type="entry name" value="ntegrin, alpha v. Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000413">
        <property type="entry name" value="Integrin_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018184">
        <property type="entry name" value="Integrin_alpha_C_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013649">
        <property type="entry name" value="Integrin_alpha_Ig-like_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048285">
        <property type="entry name" value="Integrin_alpha_Ig-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032695">
        <property type="entry name" value="Integrin_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220">
        <property type="entry name" value="INTEGRIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220:SF83">
        <property type="entry name" value="INTEGRIN ALPHA-PS3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01839">
        <property type="entry name" value="FG-GAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08441">
        <property type="entry name" value="Integrin_A_Ig_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20805">
        <property type="entry name" value="Integrin_A_Ig_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01185">
        <property type="entry name" value="INTEGRINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69179">
        <property type="entry name" value="Integrin domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51470">
        <property type="entry name" value="FG_GAP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00242">
        <property type="entry name" value="INTEGRIN_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 13" id="KW-0401">Integrin</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 13" id="KW-0732">Signal</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033097504" evidence="13">
        <location>
            <begin position="20"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="882"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="943"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="975"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1002"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1035"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1066"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1099"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1124"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1161"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="12">
        <location>
            <begin position="233"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="12">
        <location>
            <begin position="297"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="12">
        <location>
            <begin position="358"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin alpha first immunoglubulin-like" evidence="14">
        <location>
            <begin position="405"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin alpha second immunoglobulin-like" evidence="15">
        <location>
            <begin position="550"/>
            <end position="686"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF20805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAE1174645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1188" mass="136226" checksum="959AB4DF8AF7C9E7" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BA90</accession>
    <name>A0A812BA90_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Diisopropyl-fluorophosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SPHA_12126</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000402">
        <property type="protein sequence ID" value="CAE1172383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BA90"/>
    <dbReference type="OrthoDB" id="423498at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051262">
        <property type="entry name" value="SMP-30/CGR1_Lactonase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47572:SF4">
        <property type="entry name" value="LACTONASE DRP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47572">
        <property type="entry name" value="LIPOPROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032915547" evidence="2">
        <location>
            <begin position="28"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-30/Gluconolactonase/LRE-like region" evidence="3">
        <location>
            <begin position="96"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAE1172383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="390" mass="43384" checksum="C7D94697159431C3" modified="2021-09-29" version="1">MVFDFDIAIISRVFVFLLPSFLNPATATQSTHSQQITDPKTDLVLARCQYLNTCDFWWTSRRPVSLPTTTSEFDGIVTPVIEPVFSKVTEDVPGAEGPVFDKKGDFYVVAPGVENEGKPAGEILRIDLNTGKKTVICKPKVDDFGGIPAGCQCDRENNQLFVADMRLGLLIVQTDGSFEQIAKKDADDRVMQGCNDCAFDYRGDLWITAPAGDIAPAKYTRSMQEKFGSVYCFTTDGEMIRIDTGYQFPNGIAVQHMNDGRPRKLIVAETPTKKLWSYDIKGPGKVENKKVWGNIPGTHEGGADGMDFDEDNNLLVANWGSSHIEVFGSDGGEPKLRIRCPFAKPSNLQFKPQSKTVFVTEHDSNSVWKFEWQRNGKKQFSETMSSFGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BAF9</accession>
    <name>A0A812BAF9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_13687</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000459">
        <property type="protein sequence ID" value="CAE1175554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BAF9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="317"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="348"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="389"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="420"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1175554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="445" mass="53471" checksum="81C67EBBB55EB1DE" modified="2021-09-29" version="1">MLILFHYLFIILKFFFLFSFSLLIPHFFISFFPLSLFTIFSFPLSLIFLFLYFISSLSLSLHFFLSFSVFHFHFSHFYCFLFLFPLSFYFSFCFSLNHALIYQFSFLLPNVFSFILSFSFLYAFSFLPPFFSLHLSSLPFSFLYTFLLFSFLYARSPFFLLLRFFLPFFLSLRIFLPFFFLYSFSSFFPFFTLFPFSSFFLSLRIFLPFFFLYSFSSFFPFFTLFPFSLSFFLSLHIFLPFFLSLRIFLPFFLSLRFFLSPSLFSFLYTSSSLFPFFYSFSPFFLSLRFFLSPSLFSFLYTFSSSILYAFFFSPFSFLYASSLFFFTLFLPFFFTLSFPFFMLPLPPFFFLSAFSFPYFFLISNTFCFLSSALPPIISVLFSFILSSPFFLFAFIFISTFLFFSSVFIFPCFLSFLSYSLLILLHSSLFFLSPSLICFYVYLPDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BAK9</accession>
    <name>A0A812BAK9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_13149</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000438">
        <property type="protein sequence ID" value="CAE1174564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BAK9"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1174564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="351" mass="40470" checksum="07DF6E5152C70B81" modified="2021-09-29" version="1">MYAILWPLFLDSKSLTLVVYNHSTYTSNRFFDSIGRWLRLAWFYMPETTVKITGTHSETMTTEQVEKTLSLVKADVSEYIERHRQNIQKEMADILSLISSSNQPKENLDKKLLYSRQEKLSYILQIPKVQSNPSAVSCDTCKDGVGNLVKELETLTVIRSSFPHIHQRVHSSWHLFRVAIKKRTDRLFLSWEEILEITEEFPPLDHDNDSLYECLRHLHNTGEILWYSSEEDVSQFIFHQPQMFANLLADLFRNDLSDWLTETNKVLACRGVRKQDTNLKLIPFSPMPYFTWGHTHTLSLSPLSLPLSLSLFPSLSSLSLPLSLSPLSPLSLLPLSLYLSLPLSLSLSLIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BBZ9</accession>
    <name>A0A812BBZ9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_13859</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000467">
        <property type="protein sequence ID" value="CAE1175871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BBZ9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1175871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="233" mass="26080" checksum="2CBBEFBE8675240F" modified="2021-09-29" version="1">MGQVTRERFSLGRRGCIDERKLTDWIIKVKSAITQKAKKRKCNLMLPLRFRLWAKFLFITCSSVCSFFLLSLSLSFCFFPPWVLSSSSPACALLLPNLNLKFLLTLGLSHFLSSPFGFFLSSLLLTLLSLSLSLLLLLPTLHSVFSPFCTLSPFSLLHFVLPLILLLPLFGFSLTPLFPTLSLSHLLTYLGSFFLLSSPPCSLSPLLLHPHFALSLLPLFHTLCSFSHISSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BCP7</accession>
    <name>A0A812BCP7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_13222</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000442">
        <property type="protein sequence ID" value="CAE1174700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BCP7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1174700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="256" mass="30181" checksum="174BFF7746A3D0C6" modified="2021-09-29" version="1">MCLFSLLSLYELLTIFFICPSLFFQSLTSSILPDWSFSVFLSFSWSACIFVISYPSSSSSSPSSSSLSPSLALIYIFIYLSIYLSINHETVYIYYHEIVFIIYLSIYLSIYLSRDVLIYLSISKWSIYVYCDMVSIYLSIYLSIYLSIYLSITKLSISTIYHEMVFIYLSIYLSIIYLSRNVLIYLSISKWSIYVYCDMVSIYLSIYLSIYLETVYIYYLSITKRSLSIYLEMFYIYLSIYLSIYLSIYLSIYLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BCQ6</accession>
    <name>A0A812BCQ6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_13721</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000460">
        <property type="protein sequence ID" value="CAE1175589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BCQ6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1175589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="174" mass="20337" checksum="B9F4584DAD52D1D5" modified="2021-09-29" version="1">MFYPQYLSIYLSIYLSIYLSIYLYIYIYIYIYSVFLTLLFFLIAFLHFTGGHISSAILLLDLLAILFLIDFATTFEKETENDLRYFGGFSLFFNGSLLIQLSLSLSLSLSLSLSLSHTHTHTHTLSVIFFNLFFFLHYIVLFFISFSSSLSPFLFLYFFFFSLIVFTSSISLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BEP6</accession>
    <name>A0A812BEP6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_16076</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000561">
        <property type="protein sequence ID" value="CAE1226598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BEP6"/>
    <dbReference type="OrthoDB" id="9635126at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1226598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="190" mass="22252" checksum="5BA08700779F05D5" modified="2021-09-29" version="1">MLLTKNLSQPLPISIYLSIYLSIYLSISLWLYLVIYRILSISIYLSIYLSIYLSISPWPYLSIYLSHPVNIYLSIYILHPVHICLPIYLSHPGHIYISMASCKYLSIYLSIYLSIYLSIYLSIYLTLAIFIYLSHPVIIYLSIYLSIYLSIYLSIFILTTDEVVYSSALVYLEKKTLINCFKLFRSHSIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BF01</accession>
    <name>A0A812BF01_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_18863</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000680">
        <property type="protein sequence ID" value="CAE1233063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BF01"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1233063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="220" mass="26013" checksum="D68BFD1085F68DD0" modified="2021-09-29" version="1">MFLFIYEFLHLSIYLSIYLSIYLSVHIYLSLNLFISIYLFIFINLKLFVSIYLSIYLSIYLSIYLSICLSVGSYLSLLNCSYLSVSSLSIYLSIYLSIYLSIYLNLFISTYLIIFINLKLFVSISQSVYIYLSVHIYQSQIVRIYLSIYLSVSVCSYLSIYLSIYLFIFIYTKFVRTYVFMYVSIDLSLFIIYLAQSVHIYLSIYLSIYLSIYLSIYLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BGJ6</accession>
    <name>A0A812BGJ6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_16278</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000569">
        <property type="protein sequence ID" value="CAE1227041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BGJ6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1227041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="231" mass="26060" checksum="918D3B91BEC9DE06" modified="2021-09-29" version="1">MGSALVKDCSKSKTRSFVYRSKRSNESLVAVGGDVVSLNAIHRYLILFHNTKERPVCFFLLPICSHFFSFFLSLFTCLLLLSLSLSTTFSLCFPYPSLSPSHTSIPKAALVSSLPPDFLPLDYSGVYSRRLLHLSAGPSIVGITQHNAEKIISILFLSLYWRTFLGLLFIAFSLFKPIFVFFLFLLLLKHLLFDILHPLICRFHAINPICPFCIPLDTPAALRCLDCRNGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BM04</accession>
    <name>A0A812BM04_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_21324</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000781">
        <property type="protein sequence ID" value="CAE1238464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BM04"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1238464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="233" mass="28273" checksum="06952FEE8A4B047D" modified="2021-09-29" version="1">MYIYLSIYLSIYLSIYLSIYIYISISIYLYIYIYILYIYETMSGLRRDSSLSIKAAFRIWSCDMSILSIPLCIVRTFQVPGRQQLFVFLFLTTNYFEFLLPYFFFFFSHPFFNLINFVVFTFFLCTHLIILTFLSFFFYFFLILFIYLNFLLACFFILSYNLFDSPFCLFSLFFSLHIDISSKTSSIYIFLHAIDYVIYYIFFLSFFLSFFLSFFISFFLSFFLSFLPADFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BPJ6</accession>
    <name>A0A812BPJ6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NBAS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_19355</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000703">
        <property type="protein sequence ID" value="CAE1234400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="19988at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070939">
        <property type="term" value="C:Dsl1/NZR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054751">
        <property type="entry name" value="NBAS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029145">
        <property type="entry name" value="NBAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15922:SF2">
        <property type="entry name" value="NBAS SUBUNIT OF NRZ TETHERING COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15922">
        <property type="entry name" value="NEUROBLASTOMA-AMPLIFIED SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22913">
        <property type="entry name" value="NBAS_11th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15492">
        <property type="entry name" value="Nbas_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Neuroblastoma-amplified sequence N-terminal" evidence="1">
        <location>
            <begin position="4"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="NBAS subunit of NRZ tethering complex C-terminal" evidence="2">
        <location>
            <begin position="1723"/>
            <end position="1846"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF15492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1234400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="2093" mass="239693" checksum="1861C0922C1DD0CA" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BQR6</accession>
    <name>A0A812BQR6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_23456</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000868">
        <property type="protein sequence ID" value="CAE1242790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BQR6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="391"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="429"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1242790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="448" mass="51934" checksum="E1327F43E60293FC" modified="2021-09-29" version="1">MSLASASSSPPRSLSSPITHFSLSALYFFVPDTSFSPPTVSSLSTPPFTFLPLTLTPLFAPTLLHLLSPCRLFNAILSSSFSFLINHPLSHYSLHFSSSFTHFHSFVLFFFFFFFFFFFARSSSTSSSFADYLHHNGKCRDVCIFRRQDEEKDDDSDSFSFSSSSSSSNLLISLNFFFFFPSVLSFFLSFFLSSSSSSPHPPANLHISLNFLFFFTSDFSFLSFFLSFFLSFFLSSSPPPANLLISLNFLFFFTSVFFFFFFFFFFFFFFFFFFFFFSHCSLQSTQFSLLLYQSYLPLKMFFFFFYYTPYSSLIFKFYFFNSVFSSIASKFPLILYQFLLCSNTLFFSSTLSSSSSNLFLLLLLLLLLLLLLLFYIYLFYSTSSSSFSSSFSSSSLLLLPLHIYLLYSISSFLYPPPPTSSDLLILPNFFLFFFFFFVSVFTPNLILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BRE6</accession>
    <name>A0A812BRE6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_20366</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000746">
        <property type="protein sequence ID" value="CAE1236597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BRE6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1236597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="163" mass="19206" checksum="B29BD959DEE1A646" modified="2021-09-29" version="1">MRPVFLPQRLNINAFALCSSGSIMTEHKFQVRFIYYEASIFFFFLSFFLFSFFNRFIICLSFLISSFYSFPRFLPISNTLIIYFFFSLFSFYSSLFIFLSFCLSFYLFSLTCIYGSHFSAVIASLLSNNEHFKEHAHRRSLVGRSASIPGQFSEKNKIYSKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BRZ4</accession>
    <name>A0A812BRZ4_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mediator of DNA damage checkpoint protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">SPHA_20639</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000758">
        <property type="protein sequence ID" value="CAE1237199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="342264at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17744">
        <property type="entry name" value="BRCT_MDC1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18441">
        <property type="entry name" value="BRCT_MDC1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22665">
        <property type="entry name" value="FHA_MDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051579">
        <property type="entry name" value="DDR_Transcriptional_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23196:SF34">
        <property type="entry name" value="MEDIATOR OF DNA DAMAGE CHECKPOINT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23196">
        <property type="entry name" value="PAX TRANSCRIPTION ACTIVATION DOMAIN INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16770">
        <property type="entry name" value="RTT107_BRCT_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
    <keyword evidence="13" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="FHA" evidence="15">
        <location>
            <begin position="70"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="16">
        <location>
            <begin position="1168"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="324"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="424"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="575"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="737"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="906"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="263"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="351"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="372"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="399"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="429"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="489"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="619"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="740"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="758"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="799"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="827"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="856"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="871"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="906"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="932"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="946"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1099"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1130"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1149"/>
            <end position="1167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAE1237199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1381" mass="151989" checksum="FA64F0EA34C783C3" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BSL0</accession>
    <name>A0A812BSL0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_21391</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000784">
        <property type="protein sequence ID" value="CAE1238575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BSL0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1238575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="202" mass="23974" checksum="D56C55E50465135E" modified="2021-09-29" version="1">MTRLSIAASASLHLLRYFTPVFLSSASAFILSFILFTLFLFPFLSFYFYFYFLSFFFLSFFLSFFFFLSFFLSFFFLFFFLFFVLHSFFFSFFLSFFLSRFFLPSSSFYRVLVLSPPLPAMYHFSSSISRHFFIPFHCLTCFSFPLYVRSAVIMNVLCAFYYIPIFIQTAFILKSVSFSFCYSQVMPLPSSFMDSQLIGTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BU63</accession>
    <name>A0A812BU63_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_25429</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000963">
        <property type="protein sequence ID" value="CAE1247016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BU63"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1247016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="353" mass="40924" checksum="1EACCFC3134620BC" modified="2021-09-29" version="1">MTQVYTSFTYITFKVSPPAVSQCVFVVCLSRLGFSLSLSLSLVCTCSFSPPANINLPLQSAAAAVIAPPLLILAPFISPLRHFSRSPDGSIYPHRHYGFFTLLGFFFLSFFLSFFLSFFLSFFLSFCCFLFIQLFFLFSFFISRSAFYFSFFLSFFLSFFLSFFLSFFLSFSLNLSIYLSIYLSIYLSIYLSILVYLINSFFFLSFFFLSFFLSFFLSFFLSPQIIPIYLSIYLSIYLSIYLSIYLKSVNLSLSLSLYLSTYLLVCLLPCFSFFSSDFILMLYACMHASIYLSIYLSIYLSIYLSIYLSISVCSYLSIYLSIYLSIYLSQSVHYLSIYLSIYLSIYLSIYLCM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BYV4</accession>
    <name>A0A812BYV4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_26609</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001016">
        <property type="protein sequence ID" value="CAE1249479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BYV4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1249479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="313" mass="36972" checksum="BFCA1677CF2F4FB5" modified="2021-09-29" version="1">MRFTMATVLSSNSKYIQFSSAAARHIGGSVHECAFFFLFLTEYAHNTSPSPRYLSIYLSIYLSIYLSIYLSLFIYLSIYLSIYLSIYLSIYLSHFIQIHLSISIYSYLSESVYLSIYLSIYLSHFIQIHLPISLFISIYLSIYLSIYLSVYIIYLSIYLSIYLSIYLILFKSIYRSQFIHIYLSIYLSIYLSIYLILFKSIYRSQFIHIHLSISIYSYLSIYLSIYLSIYLSIPFYSNPSIDLSLFISIYLSIYLSIYLSIYLSIYLSLFIIYLSIYLSIYLSIYLSIYLSQSVHYLSLSLSISIYSYLYIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C5V3</accession>
    <name>A0A812C5V3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_30210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001213">
        <property type="protein sequence ID" value="CAE1256438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C5V3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1256438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="158" mass="18873" checksum="0CE9475BF647F969" modified="2021-09-29" version="1">MLNKINEIKIRIRFLHYINQYLSIYLSIYLSIYLSHSVVIHLSPSVCPLSFLSFHLLLTIYLSIYLSIYLSIYPILWLSIYLLPLAHSLSFLFILFYLSIYLSIYLSIYLSISFRLPTLFPFFSFLFHYLSIYLSINLSIYLSIYLSIYLTLFMYNLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C6V4</accession>
    <name>A0A812C6V4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">TNPO1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SPHA_28067</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001105">
        <property type="protein sequence ID" value="CAE1252643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C6V4"/>
    <dbReference type="OrthoDB" id="951172at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058584">
        <property type="entry name" value="IMB1_TNPO1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057672">
        <property type="entry name" value="TPR_IPO4/5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25574">
        <property type="entry name" value="TPR_IMB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25780">
        <property type="entry name" value="TPR_IPO5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="9">
        <location>
            <begin position="31"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="326"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="326"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="336"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="350"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAE1252643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="886" mass="99985" checksum="E095C1A89257AB80" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C7K3</accession>
    <name>A0A812C7K3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_29206</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001158">
        <property type="protein sequence ID" value="CAE1254792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C7K3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1254792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="157" mass="17957" checksum="8CD86B918228D76D" modified="2021-09-29" version="1">MEKKVPAWLRRSTLLSIYLSIYLSIYLSIYLSQSVPFYLSIYLSIYLSISVCSFLSIYLSIYLSQSVPFYLSIYLSHSVPFYLSIYLSISGSLHFNIRGTPIQLALSLSSDFGSQFLGEVSRFLEVSYSDVTKSLMLSIYLSIYLSIYLSIYLSILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C806</accession>
    <name>A0A812C806_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_29382</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001169">
        <property type="protein sequence ID" value="CAE1255183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C806"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="281"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1255183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="370" mass="43237" checksum="49D41A45B5947B69" modified="2021-09-29" version="1">MFTEMSKSLFLLFNISFFLSFFLSFFLSFLTYPTNRRALSRSKKHVPPQQQCFPTFKRAKEGRARKVLGFAKVLEISLTLNFFPLATGGLYKKDGIKIFATNAIDKFVSAHLGAVGATFYPPFFLLANCLLLDDQQPPLFFKPQTLQLSLHSPTPRSVLPLASSSVFCCTGLPHLLVEHCRCRLRPRQLDCLFSFLPYSIHFSLLLSFFLYFIAHFSSFFTIFSCALPFFLFCVLPFFFDFFHLYCLLLAFIIFSHFFFFPLSFFFHSFFPFVLFPSVSQFLLYICTHSISFLSLFCFCDFLSFVALHFILPHSFYNVCFFSFRYFSSSLLFVFLCLISSFLSLLFPYFVFSSFFLLYLFIFISFRFSSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C8S4</accession>
    <name>A0A812C8S4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_31572</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001300">
        <property type="protein sequence ID" value="CAE1259154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C8S4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1259154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="230" mass="26516" checksum="D1314399D0F8FB21" modified="2021-09-29" version="1">MISSSVSVSPVISSSVSVSLMISSSVSVSLMITSSVSVSLMISSSISVSFMNSSSISVSLMISSYFSVSFMISISASVHDLFICFYLTYDHYVFCLTHTLYICFFFTHEHYICFCLTPDHYICFRLTHDHYICFCLTPDHYICFCLTPDHYICFCLTPDHYICFCLTPDHYICFCLTHDHYICFCLTPDHYICFCLTHDHYICFCLTPDHYICFCLTPDHYICFCLTHTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CE10</accession>
    <name>A0A812CE10_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GAS2-like protein pickled eggs,GAS2-like protein 2,GAS2-like protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_34293</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001450">
        <property type="protein sequence ID" value="CAE1264619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CE10"/>
    <dbReference type="OrthoDB" id="206130at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035371">
        <property type="term" value="C:microtubule plus-end"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001725">
        <property type="term" value="C:stress fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008093">
        <property type="term" value="F:cytoskeletal anchor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051764">
        <property type="term" value="P:actin crosslink formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001578">
        <property type="term" value="P:microtubule bundle formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904825">
        <property type="term" value="P:protein localization to microtubule plus-end"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031110">
        <property type="term" value="P:regulation of microtubule polymerization or depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21268">
        <property type="entry name" value="CH_GAS2L1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46756:SF18">
        <property type="entry name" value="GAS2-LIKE PROTEIN PICKLED EGGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46756">
        <property type="entry name" value="TRANSGELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="1">
        <location>
            <begin position="39"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1264619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="210" mass="23657" checksum="22BDFE48AD8E3106" modified="2021-09-29" version="1">MDCADAEPSTTIVGTGSDTILVLEPKSFKPFKSKDEYLYAMKEDIAEWFTCLYNCCITVDNFFEVLETGVELCKHANAVRKFALERQDQLGNKSQFVRHIPNGEIQYKKAVKAQTFQARDNVSNFISWCRDIGVPEVLRFETDDLVLRKNERSVVLCLLEVARVGAKLGMLAPTIVQMEEEIDAELAGEPPPPTKQIITCDLKSLDEMVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CEA1</accession>
    <name>A0A812CEA1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_35312</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001515">
        <property type="protein sequence ID" value="CAE1266746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CEA1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1266746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="260" mass="29690" checksum="25A7EB2401E93A23" modified="2021-09-29" version="1">MIKREGGNAKDGSKNKHAISFCTSPSSSRSSHSFLLSSSPFALQYPSPSSIRFAVEQDNVSSSFSFLLCLSISAKITTHHNRPSVMLNHESKYANFTYLIHSLTHHSLTHSLTHSFCLSLYLSIYLSIYLSIYLSIYLSQHVHNLSIYLSIYLSIYLSICLLTHSNAHPLTHYLSIYLSIYLSIYLSIYLSIYLFTYSLKRTPTHSSLSIYLSIYLSIYLSIYLSIYLSQFVLNQSIDLSIYLSIYLSIYLSIESVHIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CHP5</accession>
    <name>A0A812CHP5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_33825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001424">
        <property type="protein sequence ID" value="CAE1263647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CHP5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1263647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="162" mass="19119" checksum="227A084E27A0A8FE" modified="2021-09-29" version="1">MPPSPVDAGTEYALTVFFLSFYSPFNLSSCCILLFPSPFLSFFLSFFLSIHLLIYLHAVSSCFLLPFFFLRFFLSFFLSFFLSFFLSLYSPINLLSCCFQLFSFSFLSPFFLSFFLSFFLSFFLYIPLLIFFHAVSCSIILFLSFFFLFFLSFFLSFFIFAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CHS6</accession>
    <name>A0A812CHS6_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 11">Adenylosuccinate synthetase</fullName>
            <shortName evidence="9">AMPSase</shortName>
            <shortName evidence="9">AdSS</shortName>
            <ecNumber evidence="9 11">6.3.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">IMP--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SPHA_35527</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Farmed</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.</text>
    </comment>
    <comment type="function">
        <text evidence="11">Plays an important role in the de novo pathway of purine nucleotide biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9 11">
            <text>IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15753"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="6.3.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9 11">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 9">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 11">Belongs to the adenylosuccinate synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.4" evidence="9 11"/>
    <dbReference type="EMBL" id="CAHIKZ030001531">
        <property type="protein sequence ID" value="CAE1267240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CHS6"/>
    <dbReference type="OrthoDB" id="10265645at2759"/>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004019">
        <property type="term" value="F:adenylosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046040">
        <property type="term" value="P:IMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03108">
        <property type="entry name" value="AdSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.170.10:FF:000001">
        <property type="entry name" value="Adenylosuccinate synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.300.10:FF:000002">
        <property type="entry name" value="Adenylosuccinate synthetase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.440.10">
        <property type="entry name" value="Adenylosuccinate Synthetase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.300.10">
        <property type="entry name" value="Adenylosuccinate Synthetase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.170.10">
        <property type="entry name" value="Adenylosuccinate Synthetase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00011">
        <property type="entry name" value="Adenylosucc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018220">
        <property type="entry name" value="Adenylosuccin_syn_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033128">
        <property type="entry name" value="Adenylosuccin_syn_Lys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042109">
        <property type="entry name" value="Adenylosuccinate_synth_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042110">
        <property type="entry name" value="Adenylosuccinate_synth_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042111">
        <property type="entry name" value="Adenylosuccinate_synth_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001114">
        <property type="entry name" value="Adenylosuccinate_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002223">
        <property type="entry name" value="PRK01117.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00184">
        <property type="entry name" value="purA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11846">
        <property type="entry name" value="ADENYLOSUCCINATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11846:SF0">
        <property type="entry name" value="ADENYLOSUCCINATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00709">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00788">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01266">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00513">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 9 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 9 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 9 11" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="89"/>
            <end position="95"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="90"/>
            <end position="93"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="115"/>
            <end position="118"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="117"/>
            <end position="119"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="374"/>
            <end position="380"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="378"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="380"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="406"/>
            <end position="408"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="488"/>
            <end position="490"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00050432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAE1267240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="500" mass="54947" checksum="1B1F7E027973A146" modified="2021-09-29" version="1">MFNERGGGASPTPPDFALNSLRMRTTCKQAMATEGGKVNSSGVNVSHSITESNGSAPSDNLNGEVNCQTKRAKMSSTEVVTVVVGTQWGDEGKGKVVDMLAQSAEVVCRCQGGNNAGHTVVVDDIVYDFHLLPSGIVHPTCDVVIGNGVVVNLPELFNEIEKNEGKGLTNLEKRLKISNRAHLVFDLHLKLDGVQEMKRGRNSIGTTKKGIGPTYASKATRNGLRICDLVGDFEYFAEKFRNLMEYHKTSCPELEIDVEVELIKYKKLREKVMPFVVDTVLYMNKAIESGRKILIEGAQSTMLDIDFGPYPYVTSSNCSVGGVCTGLGIPPRNIGNVYGVVKAYLTRVGSGGFPTELLNETGELLQKRGHEFGVTTGRKRRVGWLDMVMLRYSHMINGFSAVAITKLDIMDVLEEVKIGVSYKLNGKPIESIPASDEDLKRVEVEYITLPGWKTSTEDVRKFSDLPENARTYVRTIEELLKVPVKWIGVGKARASMIQVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CJG6</accession>
    <name>A0A812CJG6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_38673</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001768">
        <property type="protein sequence ID" value="CAE1274177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CJG6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1274177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="196" mass="23630" checksum="AC678091027EE6CD" modified="2021-09-29" version="1">MSSSSLCPRVARTYLAKISSLFFLYLSLSLSLSFSLSLSFHTLLLSVFVFLFFARDFLDVLILFLFFYHSSLFFFLSSFISFSSYSLFPLSSFHASSFSFFNLISLCSFLYIYIFCLFIQNTFFFQTLFQFSMLSTDSLRFSFFSRFILFFSFFFRFHFVFYLFFDYLFFFLSHSFNHFWYVTLFSFHNKNVDKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CMU5</accession>
    <name>A0A812CMU5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_36952</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
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            <taxon>Mollusca</taxon>
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            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001632">
        <property type="protein sequence ID" value="CAE1270197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CMU5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <begin position="20"/>
            <end position="41"/>
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    </feature>
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            <begin position="75"/>
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        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
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        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
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        </location>
    </feature>
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            <begin position="278"/>
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        </location>
    </feature>
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        </location>
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            <end position="369"/>
        </location>
    </feature>
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        <location>
            <begin position="389"/>
            <end position="416"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1270197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="421" mass="48764" checksum="55F5491868878FEE" modified="2021-09-29" version="1">MFSFMIKLVFSHLYRSLSLSLSLFLSIYLSIYLSIYLSIYLSRSSQDLSIYISISVFSGSIYLSIYLSIYLSIYLSIYLTFLFSLYCTISSFVSFYLSIYLSIYLSIYLSIYLSISVFSGSIYLSIYLSIYLSIYLSISISVCSYLSIYPAIHLSIITIFSIKAFLFSLYCTISSFVSFYLSIYIYLSIYLSIYLSIYLGLFRIYLSIYLSIYLSIYLSIYLGLFRIYLSIYLSIYLSIYLSRSFQDLSIYLSIYLSISVFSGSIYLSIYLSIYHIQFSSISITAYSLSVYLSIYQSRPSSIIIFSFSFYYTFSFSASFNLSIYLSIYLSIYLSIYLSISVCSYLSIYLSIYLSIYLCISVCSYLSIYPSIHLSIIDILSTPSLSIAEFLPLFLFIYLSIYLSIYLSIYLSIYLSIIDILF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CNZ6</accession>
    <name>A0A812CNZ6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_40913</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001946">
        <property type="protein sequence ID" value="CAE1277874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CNZ6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="109"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1277874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="263" mass="30118" checksum="ECF2779864F3D612" modified="2021-09-29" version="1">MNRKKNFFLSSLLTAEITSNTDSYVYNIYLSIYLSIYLSIYLSIYLSIYLSILINSFLLEITSLQNNLLLFFSFSFSHSLSLSLFLYLILSLSISFSISLSFSFSSLCIPSPSFSLSFSLYLSLLLFLSLLLYLSILLFLLTLYPISLFLSTTFSLYFSILPFLSISASISLSTLFLSLLLSSLCRFSPNLSLSLSLRFFILSHSFSSLALFLFLSLYLLPLCLNLILSFSFTLFLFPYLLHSSFPKTCVDDFTFFFNRQLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CUC0</accession>
    <name>A0A812CUC0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NEBL1_2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_41837</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002023">
        <property type="protein sequence ID" value="CAE1279539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CUC0"/>
    <dbReference type="OrthoDB" id="6157334at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046852">
        <property type="entry name" value="Neurobeachin_a-sol"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20425">
        <property type="entry name" value="Neurobeachin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="329"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="407"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="430"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="456"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="482"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="510"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="Neurobeachin alpha-solenoid region" evidence="2">
        <location>
            <begin position="832"/>
            <end position="970"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1279539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1059" mass="127109" checksum="B0D8759610E5A851" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CV04</accession>
    <name>A0A812CV04_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_40393</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001903">
        <property type="protein sequence ID" value="CAE1277060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CV04"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1277060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="204" mass="23776" checksum="E16F28E6F2033FE5" modified="2021-09-29" version="1">MTFSLSFSEKSKSALSIYLSIYLSIYLSIPSSLSSFFFLSVSLISSSISIYLSIIYLSIFIILFSIYVNPSFCSIYLSIYLSNSIISIYSNLSLSYLSKFLFISMKFCSYLSIYLSIYLSIYLILFISMKFCSYLSIYLSIYLSKSIFVLYLFLFIYLSIYLSIYLSIYLSICLILFIYIYQSICIILLIFIFIILFTSIYLKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CVM6</accession>
    <name>A0A812CVM6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">P4HA</fullName>
            <ecNumber evidence="2">1.14.11.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_41040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.2" evidence="2"/>
    <dbReference type="EMBL" id="CAHIKZ030001958">
        <property type="protein sequence ID" value="CAE1278078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CVM6"/>
    <dbReference type="OrthoDB" id="420380at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013547">
        <property type="entry name" value="P4H_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08336">
        <property type="entry name" value="P4Ha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prolyl 4-hydroxylase N-terminal" evidence="1">
        <location>
            <begin position="20"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1278078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="217" mass="25385" checksum="F172ECFC0E2E3060" modified="2021-09-29" version="1">MEEVNCPDCESDNNTEVFVTKFKKIQESLWPTEKDIKGAALAIFRIINLYRLNITELMLGNIKNYTTSPMTTKEVFQISHVASDENMIYDEIVWLQALYKLFKENRIEKGVYSLEHIDRSLASAYSRYGMPWESLKYIQECLETKPDNKGCLRDKVYYEMKVKDIPATSREKKLEKENKTEDKIKYEALCRGDKLLSDTAVARQNVSFVQCRFLTKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CWI1</accession>
    <name>A0A812CWI1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_42987</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002124">
        <property type="protein sequence ID" value="CAE1281597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CWI1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1281597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="157" mass="17978" checksum="600CA491E1E3CD67" modified="2021-09-29" version="1">MLCVSLVPKVAVTRAVEDTRDISCMREFSLFAKNYPYLSIYLSIYLSIHFLKFLTSLRMCSYIAFSYTVSTLYTSRAPLYILHFVLLHISFNFTAFSLFFPFSLSLGLTLHYALFLLSRVITKVILPFTLPLSPSPCPTYSIFLFPTPQKISSASFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CX71</accession>
    <name>A0A812CX71_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_41484</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001993">
        <property type="protein sequence ID" value="CAE1278845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CX71"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1278845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="308" mass="36075" checksum="8E0CD259CB1E1CA8" modified="2021-09-29" version="1">MAVCLFFFLLHPFFLSYLFLLHCSFKVSFLILSFSSDFLSTFSPPPLISFSLLLHHTVLFIGNKSVNIYLSIYLSIYLSIYLSISPDLSIYLSIYHIIYLSIYLSISVCSIFKSVTIYQYFYLSIYLLIYLPLTSSYVSIYLSNDFYCQLSILSMTRIYLLSLSLPLSLSLCLFTHYISLSFSLSFSLTRAHTHSYRYTFNFSWISIYLSIYLSIYLVYCSYIINSYLSIYLSIYLSIYLSISPFSNLSIYLYIYLSSLLFLYQLISIYLSIYLSIYLSIYLSSLLSVHIYLSIYLSIYLSIYLSIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CXD6</accession>
    <name>A0A812CXD6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SLC12A8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SPHA_42741</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002101">
        <property type="protein sequence ID" value="CAE1281126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CXD6"/>
    <dbReference type="OrthoDB" id="2020542at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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    </protein>
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        <dbReference type="NCBI Taxonomy" id="158019"/>
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                <person name="Li R."/>
                <person name="Bekaert M."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">Farmed</strain>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">Farmed</strain>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <sequence length="997" mass="115579" checksum="CCA88CBE649BEF3D" modified="2021-09-29" version="1"> </sequence>
</entry>
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    <accession>A0A812D5N7</accession>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="307" mass="37059" checksum="68D7080B1DDEFBFC" modified="2021-09-29" version="1">MALFLHSFFDLISFFLSFFLSFFLSFFLSFFFFFFYPSLLPSFSFFLPFLFLFSFFFYFLRPYHSFFLSFFLSFFLSFFLSFFLSSFRIPIFHLSIYLSIYLSIYLSIYLFLMNYSPNTRPKTHSSIFKSIYLSIYLSIYLSIYLSFSVYIYLSIYLSEFISISIYLSLYLHISVSLFLSFLLSIYLSIYLSIYLSIYLRTFLQCFIYSLYSYLSIYLSIYLSIYLSNLICLNLSIYLSDIFKSIYLSIYLSEYIHIYLSIYLSIYLSLFISIYLSIYLSIYLSIYLNLSKSIYLSIYLSIYLSIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D5V2</accession>
    <name>A0A812D5V2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_46573</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002468">
        <property type="protein sequence ID" value="CAE1287413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D5V2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="287"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="338"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="374"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="433"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="463"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="547"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="578"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="612"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="641"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="682"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1287413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="719" mass="87001" checksum="A911B2AA8F40184F" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D6X8</accession>
    <name>A0A812D6X8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_48330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002678">
        <property type="protein sequence ID" value="CAE1290691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D6X8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1290691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="216" mass="25189" checksum="ACC2B8360A7F1C4D" modified="2021-09-29" version="1">MLDKPARTERLTAGSERECSQGANEGFLDVCDSISFRYKYFLDNEVHRSNNQSIYLSIYLSIYLSVCLLLISSYLSICLCLLISISVYLSIYLSICLFIYIYVNFISIYLSIYLSIYLSIYLFICICLFHIYLTIYLSIYLSIYLSICLFICIYAHFISIYLSVCSYVYMSISYLSIYLSIYLSIYLSIYLFSQPLSLPLSITFSLFMFVSHSILY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D8M4</accession>
    <name>A0A812D8M4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_50698</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003005">
        <property type="protein sequence ID" value="CAE1295011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D8M4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="86"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="137"/>
            <end position="158"/>
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            <end position="211"/>
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        </location>
    </feature>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="277"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="298"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="327"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="372"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1295011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="393" mass="47190" checksum="E3E2A8BA57033634" modified="2021-09-29" version="1">MIFLFSFFLFQKQFFLFFLSFFLSFFLSFFLSNQVRHSFFLSFFLSFFLSFFLSFQPIPDSPSFFSISIHSFFLLIFFLSFLSFFLSFQPILIPLLTCPSPCSFHFFLSFFLSFLSFLSFFLFFSFFLSFISNQVRHFFLFLLFFLSFFLSFFLSFFFKTIQTSFFFLFLSFFLSFFLSFFPTNSDSPSNLSISMFFHFFLSLFLSFFLSFQTIQTLFLSFFLSFFLSFFLSFQPILIPLLTCPSPCSFISFFLSFFLSFFLSFFLSFFLSFQSSQTFFLSFFLSFFLSFFPNNSDTLSFLSFFLSFFLSFLFSTNSDSPSNLSISMFFHFFLSFFLSFFLSFFPIKSDILSFFLSFFLSFFLSFQTIQTLFLSFFLSFFLSFFLSFFLSNQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D950</accession>
    <name>A0A812D950_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_49476</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002837">
        <property type="protein sequence ID" value="CAE1292830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D950"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="291"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1292830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="392" mass="45562" checksum="27814152958D564F" modified="2021-09-29" version="1">MTLSYSLFLKTIYSLSIPFFLSFDWLTNEIFSYLSIYLSIYLSIYLSISIFSYLSIYLSIYLSIYLSISVCSYLSIPIYLTLFLSVYLSIYLPVHFRLFISIYLSIYLFISLSILCVLIYLSHPVLIYFTLFLSIYLSIYLSIYLSIIVWTLLFIYLSYSVHFLYLYIYIDSLFLSFFLSFFLSLSILSECFIRSFLITSSIYLSQLISIYLSIYLSIYLSCHSLSFFLSYSAHLSFFLSFFLYLVRMFHWFFSNHFIYLSIYLSIYLSCHSLSFFLSYSAHLSFFLSFFLSFFLSFSILSECFIGSFLTTLSIYLSIYLSIYLSQPSKDSRKMSGFLGEHHTQDLGPSAAIEVVQSVVRHGDSGSENIAKKERSDKIPAGAVLIDVATVCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DB02</accession>
    <name>A0A812DB02_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RPC2</fullName>
            <ecNumber evidence="1">2.7.7.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_49438</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="1"/>
    <dbReference type="EMBL" id="CAHIKZ030002827">
        <property type="protein sequence ID" value="CAE1292744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DB02"/>
    <dbReference type="OrthoDB" id="10324762at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1292744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="150" mass="17613" checksum="F8FB19878B39F7DA" modified="2021-09-29" version="1">MFNLFFFSLQGVQGVCETNVEETAKRCLSRSMTPTISSGDLLRKDITSLTPGQMKELCQLFRNFEDCIQEELYACIDNKHELKKILESFEHSFNYICHEGFELLMKIKPCTEKPEFKKQMGQCSESAIYRFNETKMRLMTNYMIKEKACR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DB90</accession>
    <name>A0A812DB90_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Signal peptide peptidase-like 2A,Signal peptide peptidase-like 2B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SPHA_50255</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase A22B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002940">
        <property type="protein sequence ID" value="CAE1294214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DB90"/>
    <dbReference type="OrthoDB" id="29661at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098554">
        <property type="term" value="C:cytoplasmic side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030660">
        <property type="term" value="C:Golgi-associated vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098553">
        <property type="term" value="C:lumenal side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042500">
        <property type="term" value="F:aspartic endopeptidase activity, intramembrane cleaving"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033619">
        <property type="term" value="P:membrane protein proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007369">
        <property type="entry name" value="Peptidase_A22B_SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006639">
        <property type="entry name" value="Preselin/SPP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12174:SF103">
        <property type="entry name" value="INTRAMEMBRANE PROTEASE (IMPAS) FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12174">
        <property type="entry name" value="SIGNAL PEPTIDE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04258">
        <property type="entry name" value="Peptidase_A22B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00730">
        <property type="entry name" value="PSN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="261"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="292"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="339"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="426"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="461"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="488"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="576"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="661"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="702"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="731"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="9">
        <location>
            <begin position="97"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="617"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="768"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="768"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="786"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="799"/>
            <end position="808"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAE1294214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="808" mass="90865" checksum="4FEF46DDB0927FFE" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DBV5</accession>
    <name>A0A812DBV5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_50096</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002926">
        <property type="protein sequence ID" value="CAE1293956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DBV5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1293956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="183" mass="20908" checksum="9B5766424DAFAE61" modified="2021-09-29" version="1">MLSYRGTLPLSRKIVVTGVVSASSQSSLHCWRVSNKSRGSKTMCDKSQDGELSPLSLFGKIFARDCHDDLIKLSGVKCGRKNLPTCLSVYLSIYLSIYLSIYLSIYLSQSLEIYLSIYVSLWSIYRCTLSISIYLSIYLSIYLSIYLSIYHRDFPITEINSVHIYLSIYLSIYLFLYFSISLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DCG9</accession>
    <name>A0A812DCG9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_49327</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002811">
        <property type="protein sequence ID" value="CAE1292557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DCG9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1292557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="202" mass="23849" checksum="0E01CAA65EFCC16A" modified="2021-09-29" version="1">MKKISEIFIYLSIYLSIYHSLFIVYHNFSLHIYLSIYLSIYLNFFFYLSIYLSIYLSIYLSIYLSRSVHIYLSIYLAIYLSISGCSDLLIYLFQYIHIYLSIYLSSFLSISVCSFSFFLFLILSIYLSIYLSIYLSIYLSLFVHTYLPVYLSISSCSDLPICLFLSISVYSYLSIYLSIYLSITLFISTLYLSLFISMYISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DDN7</accession>
    <name>A0A812DDN7_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase A2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_49936</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002906">
        <property type="protein sequence ID" value="CAE1293653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DDN7"/>
    <dbReference type="OrthoDB" id="6144264at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000130">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon opus-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053134">
        <property type="entry name" value="RNA-dir_DNA_polymerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559:SF435">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559">
        <property type="entry name" value="TRANSPOSON TY3-I GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1293653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="174" mass="19727" checksum="C29B7C1B51D5889E" modified="2021-09-29" version="1">MSFLIDTGAQLSVVPPSPNFTKTNSSVTLRAANGTNIKTFGEQSLTLDIGLRRTYQWIFTIADVKFPILGADFLAHYQLIVDLSQQPVKHNTVHRIRTTEQPVYSKPRRLAPDKYKIARAKFQHMLDLGIIRPSSRPYASPLHMVTKAQQGAWKPCGDYRRLNSQYPISTQFPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DDR7</accession>
    <name>A0A812DDR7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SDK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SPHA_51830</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003165">
        <property type="protein sequence ID" value="CAE1297112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DDR7"/>
    <dbReference type="OrthoDB" id="6158926at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000028">
        <property type="entry name" value="Neuronal cell adhesion molecule"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170:SF6">
        <property type="entry name" value="CONTACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170">
        <property type="entry name" value="PROTEIN SIDEKICK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="588"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="611"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="642"/>
            <end position="664"/>
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    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="670"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="698"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="730"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="852"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="886"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="917"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="958"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="987"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1021"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1051"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1084"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1113"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="122"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="217"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="6">
        <location>
            <begin position="274"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="6">
        <location>
            <begin position="381"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="6">
        <location>
            <begin position="483"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="358"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="364"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAE1297112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1136" mass="126119" checksum="B48FBD2886787380" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DE73</accession>
    <name>A0A812DE73_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SPHA_50750</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003010">
        <property type="protein sequence ID" value="CAE1295077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DE73"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51225">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="291"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="320"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="353"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="377"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="408"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="439"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="476"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="502"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="529"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="7">
        <location>
            <begin position="28"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAE1295077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="561" mass="70946" checksum="E5B300C3776A16FA" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DEP9</accession>
    <name>A0A812DEP9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RPS6KB</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_52386</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CAHIKZ030003250">
        <property type="protein sequence ID" value="CAE1297979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DEP9"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="305"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1297979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="351" mass="39217" checksum="B90B1A272E6FE692" modified="2021-09-29" version="1">MLSYTVKIESVVDGDFIVYLLNLPNLSKIFFLSFKHLEYYFRISPNRLKLKKPTIFKKILPSFPPLLPLLPFLPPSFLPSSSFLPPLLPPPSFLPSFLPSPSSLLPSFLPPSLPPSFPPSFLPSLLPPSFLPSLLPSLHPSLHPLPPSPFPSLPLPPSFLPSFLPPSSFLFPPFPSLFPSLLPFPSFSFPSLPPFLFLPPSFSLPSFPPPSFSFLPFFLPPSLPSFFFLPSFLLPFPSLPSSFPFSFSLPPPSFSFLSFLFLPSDLHELDAPPSKHLEMNGDMETVELSDETVNPGQHKVGPQDFQLLRVLGKGGYGKVFQVRKVSGDDKGQIFAMKVLKKVTFFIFWYHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DH71</accession>
    <name>A0A812DH71_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SPHA_52887</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003326">
        <property type="protein sequence ID" value="CAE1298885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DH71"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="218"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAE1298885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="256" mass="29121" checksum="99345D0B90D6ECB7" modified="2021-09-29" version="1">MSVSFLKKAAEIHDMVAYFPTVVKIQDVDMHFASMHSIYLSIYLSIYLSIYLSIYLSNSVHSLYLFLSIYLCSYLSVNLILFIMSPPPLSINLSLISIYLSIYLSISLILTLFISIYVILFIISPPFSFHEFVCSYLSNSVHFLSFPTSLSQSICSLSIYLSNSLHYLTFLSLSLSVYLSPFISIYQILSIISLYQSLFIPIYLSHSVHYLSSPLSQSIYLTVSFFLSIYLSIYLSIYLSIFSTAAKNSTLLQTKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DHF4</accession>
    <name>A0A812DHF4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">KLHL21</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SPHA_52313</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003239">
        <property type="protein sequence ID" value="CAE1297931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DHF4"/>
    <dbReference type="OrthoDB" id="6418787at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.420:FF:000001">
        <property type="entry name" value="Kelch-like family member 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412">
        <property type="entry name" value="KELCH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412:SF441">
        <property type="entry name" value="KELCH-LIKE PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="321"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="358"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="392"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="5">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAE1297931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="421" mass="49121" checksum="07F9EEFADEA4CE69" modified="2021-09-29" version="1">MFTSDLRESREARVCISEVSPWTLKRVIEYAYSGRIAITDENAQELLAAGSLFEYPDIVGACCEFLRRQLDHNNCLGIERFAQVHSCKELQTDAHKYTLENFSMVVKSDEFLELSPERLLIYISSDLIDVRKEEIVYDAVIRWVRYDLDDRSRHLTSLLQQVRLPIVELSYLREIEADPLIYNQPDCLDLIREAQVQHESVSNQQGKRRRSMQNNNVHPRPSTVAKEALVVVGGLNNYITRSVEMYDLQKDRWTNLPDIPQPISQYSVAMLTNALIVSGGICDGHIVDTVWRFDALKLEWKNMQPMLRPRARHASTSINDYVVVFAKILSVTLSACLSLSFFLSFFSFVLSFSSFFTFFLFCFFFPFVHSFFLFFVFSSVLYFFFFLSFFPFFSFLCFFLSFILSFFLFLFFSFLFVLTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DK03</accession>
    <name>A0A812DK03_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7041 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SPHA_54338</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003533">
        <property type="protein sequence ID" value="CAE1301336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DK03"/>
    <dbReference type="OrthoDB" id="6233583at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055469">
        <property type="entry name" value="DUF7041"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327">
        <property type="entry name" value="ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327:SF3">
        <property type="entry name" value="RNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23055">
        <property type="entry name" value="DUF7041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7041" evidence="3">
        <location>
            <begin position="22"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="210"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="182"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="220"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAE1301336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="281" mass="31949" checksum="092603BDF2C42D16" modified="2021-09-29" version="1">MADPVPITETAIRLEMPVFNSNVQTWFLQLGAIFQARHITSQQSKFAAVVEKLPAEVAAEVADILTSLPIDKPYETLKQAILHRSGFSEERKIRDLLTNVTIGDAKPSQLLRRMQQLLGDNDISTTVFRQMWLDKLPADIVRILAALADDVNIKKLATIADKVADTTPIQHISATETVDGLVPDVNRQIQKLSSELQEISIQLRDLQKSQISRRDNFTKHNNHSSRSTSRHKYQQRRDRYQYANCWYHENFGARAKKCRPPCSYRKLFPSNQAGNEPTGTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DMC7</accession>
    <name>A0A812DMC7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_57014</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003815">
        <property type="protein sequence ID" value="CAE1304441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DMC7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1304441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="363" mass="39543" checksum="43A5854E55B31DAF" modified="2021-09-29" version="1">MQRLRIDKLLGPQKVADVADAIADMERYIPRHAKMAMLDLVLAWARVDTTIAQLATAAFNMDPTVGAIGRSFGKLAVEVIPIAVMKKRRHSRGTSTKKRWRCWMSNGSGKTKTRPGGMRTYLPAPSMTGFPTPPAISLSHGRACWTGRSCVQRVAVCSHDPIVVGPRRYRVEEPQIVRVLPRHRRLAYVTLRRQVGGGRQDSFGGDGGIFISRSATGGDHVAIANRVIHALQQQAADRGVLVDRHRHPRIAIPPVMSETFSPVIAGKRIVPPEPSTTGLVAFASQKRPSAGSDGDSAKGRANAAAVQFYRRSDLKVASNSVVVIELDDPLLAAFQATQADGGAINRARLRPQPYPLARRIARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DPK0</accession>
    <name>A0A812DPK0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HEAT repeat-containing protein 5B,HEAT repeat-containing protein 5A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SPHA_59811</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Farmed</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HEATR5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004146">
        <property type="protein sequence ID" value="CAE1307818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="192608at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000138">
        <property type="entry name" value="Putative HEAT repeat-containing protein 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040108">
        <property type="entry name" value="Laa1/Sip1/HEATR5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046837">
        <property type="entry name" value="Laa1/Sip1/HEATR5-like_HEAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21663:SF0">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21663">
        <property type="entry name" value="HYPOTHETICAL HEAT DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25468">
        <property type="entry name" value="HEAT_HEATR5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20210">
        <property type="entry name" value="Laa1_Sip1_HTR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1581"/>
            <end position="1599"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1606"/>
            <end position="1625"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1631"/>
            <end position="1648"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1655"/>
            <end position="1673"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1710"/>
            <end position="1730"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1742"/>
            <end position="1768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="720"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="729"/>
            <end position="740"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAE1307818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1933" mass="211706" checksum="CB75F90AA6C1DC41" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DSZ0</accession>
    <name>A0A812DSZ0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_58009</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003940">
        <property type="protein sequence ID" value="CAE1305607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DSZ0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1305607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="176" mass="21200" checksum="1773434B73093749" modified="2021-09-29" version="1">MVKPGLTGNGILFLSFFFFLYFLSFFFLSLCLHSSLPFLFAFFVSFSFLLPFFFLSFLYFSFFSFFLPFFLSFFFPFFFFLSFLPLFLPSLLTFFFLSFLFISFFFLSFFRSSFFPSFFFFLSFFRNLFLFSVSPSFHSFFYSFLFLSLSICLSLSPYLSIYLSIYLSIYLSIYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DU45</accession>
    <name>A0A812DU45_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sigma non-opioid intracellular receptor 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Sigma 1-type opioid receptor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SPHA_62361</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the ERG2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004457">
        <property type="protein sequence ID" value="CAE1310843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DU45"/>
    <dbReference type="OrthoDB" id="347124at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005640">
        <property type="term" value="C:nuclear outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006716">
        <property type="entry name" value="ERG2_sigma1_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10868">
        <property type="entry name" value="SIGMA 1-TYPE OPIOID RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10868:SF1">
        <property type="entry name" value="SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04622">
        <property type="entry name" value="ERG2_Sigma1R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032556267" description="Sigma non-opioid intracellular receptor 1" evidence="12">
        <location>
            <begin position="21"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAE1310843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="256" mass="28997" checksum="40BFF4C55C978802" modified="2021-09-29" version="1">MPSIFAWVAYVLLAVGLIHQWLKQKEYVFSHDIIATIANRHIPKTDRDLEASMTSLVSELQSKYPGHILPTKDLQWFFINRAGWMASICILHASLTEYVALLGTAMETSGHSGHYFINISDTLLSGKFHRWKEGEFRSKTFTAGDTIYHLAGEASGVHWTAGTYMIEYGRGFLISALPTAFADVIFSTHDFVSMFQVLKLSYTHLFASEVFSSKADLRNNLHSVKFIEKGFFISKLQTRKSVVIGYFTRIRNITLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DUK9</accession>
    <name>A0A812DUK9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_61743</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004385">
        <property type="protein sequence ID" value="CAE1310128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DUK9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1310128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="227" mass="26796" checksum="2E9A7DFAAB1DFBF6" modified="2021-09-29" version="1">MYNFPFNKRACAKCLPCYNNSHDRLNNLFTRVVSSFLLFLNIGPFYGIEIVITHSFFRFFFFLSFSHPFFNFSFFFLSFIFLSSPFLSFFFFLSFSFFLFSFFFLSISFFLFLSFYFLSLSFCFLSLFHSELFYVCLFLPFFPNSFIFLSFFLSFFLSFFLPNSFSSLSLSLSLSLGSSSALCHQYLSNTFIYLSIYLSIYLSIYLSIYLSISTGNGITQYSSFIKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DV06</accession>
    <name>A0A812DV06_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_61349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004332">
        <property type="protein sequence ID" value="CAE1309643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DV06"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1309643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="275" mass="32756" checksum="8482D6603DAAF278" modified="2021-09-29" version="1">MISKTFFLPNFFVSLHFLTWFLILSLFLPNFSVDLLFLTWFLRASFFSFLISLSLYPFIHGFKDFLPNFSIFLHFLTCLPGFLSFFLISLSLYLFLHSYLFHSISLFHSLFTPSSLFLSSYFHSPIICFEFLFPFIHSLYFSTFSFLHLISLYFFFHGLSVSRIILSFSLISFSLISFILYFLIFFVYFNSLSSTFHTLSLLFIISFFLLFFSSILLSNSLTFFFLDFSFFFICLLQISFNSPFHISHLLTRFFAFSFFLSFFLSFFLSFFLSFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DW36</accession>
    <name>A0A812DW36_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_63302</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004539">
        <property type="protein sequence ID" value="CAE1311940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DW36"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1311940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="206" mass="24312" checksum="29D448AFC0E78149" modified="2021-09-29" version="1">MIKLLSTESSSWNRYYHSFFSYLSIYLFIYLGLFLSIYLSIYLSIYPDFSPLFCTSIYLSIYLSRFLSSLLYLYLSIYLSIYLSIYLSIYLSIYLSVNVDIYLSIYLSIYLSIYLSIHRSLSLSVYLSIYHRQFKSIYLSIDKELSDNTVAILTSFAILVSVFFQSVFISPFFLFFSLSLFAFMRYTFFARSTKLKSQFTNFSSPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DY13</accession>
    <name>A0A812DY13_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_62846</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004498">
        <property type="protein sequence ID" value="CAE1311428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DY13"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032543177" evidence="2">
        <location>
            <begin position="20"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="307"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="361"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="405"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1311428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="432" mass="50992" checksum="D18D5A4A70B088E9" modified="2021-09-29" version="1">MFNLSLSLSLSLSLSLSLSLSLNAIYTLSEVFTLSIYLSIYLSIYLSIYRICLELFEQPSYLSIYLSIYLSIYLSISACSLSIYLSIYLYISIYFMLFISISFWFYLSIYLSIYLFSYLSSYLSLLISIYLSIYLSISDFSYMTCHYVSIYVSRSFPIYLSMYLSIIIYFHLFFIDSLFFFTVYFNFSVRPPTLSGHPCPFFTFFFHFFSLILSIPNLCRCVYVYMFTNICLSLSPLSFFFFFHRIFQFFCPPPTLSGHPCPFFTFFFHFFSLTLSIPNLCRCKYIHPIKIYPTTSPSLSHSLSLSLFLFLSLPFFFSLLFFFLFFFISFSLSFFLSLFISHHKARRTWSSHVEFISLISIYLSIYLSNSVHIYLSIYLSIYLSIYLSESVHYLSDSVHIYLSIYLSIYLSIYLSIYLSLFISIYLSIYLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DZU3</accession>
    <name>A0A812DZU3_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10">Leishmanolysin-like peptidase</fullName>
            <ecNumber evidence="10">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SPHA_65691</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Farmed</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9 10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9 10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the peptidase M8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="10"/>
    <dbReference type="EMBL" id="CAHIKZ030004725">
        <property type="protein sequence ID" value="CAE1314619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DZU3"/>
    <dbReference type="OrthoDB" id="527990at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001577">
        <property type="entry name" value="Peptidase_M8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10942">
        <property type="entry name" value="LEISHMANOLYSIN-LIKE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10942:SF0">
        <property type="entry name" value="LEISHMANOLYSIN-LIKE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01457">
        <property type="entry name" value="Peptidase_M8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 10" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 9 10" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="210"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601577-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601577-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAE1314619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="238" mass="27557" checksum="678C97D495EB5A6A" modified="2021-09-29" version="1">MQYCVGKCAKKTICGDITIPEEHLETCYCVHCDSDGYQQRGTKGPGVNNTDFILYVAALSSERCHHGNTIAYAAYCQQERSLDRPVAGYFSICPNSLSTSPQLLSTIKHEILHALGFTAGLYAFYRDRDGNPLTNRSENLDAFFSPFSFTNFPFSFFDFLFLIFPFLFFLFSIFLCLFSFLFPFLSFFVLFVLFCSFCPFLFFFNFLLFFYFLFLAFFAFFSFFSFPVLLSLFLLFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E128</accession>
    <name>A0A812E128_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_65937</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004744">
        <property type="protein sequence ID" value="CAE1314945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E128"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1314945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="260" mass="30042" checksum="32570E5FC2E2E385" modified="2021-09-29" version="1">MSTDLGVDKNAIYSGQRIELGWSWRFFHLSIYLSIYLSIYLSIYLSIYLSNSVSIYLSIYLSIYLSIYLSISVIHIYLSIYLSIYLSIYLSIYLSISVIQYLSIYLSNSISIYLSIYLSIYLSIYLSISIPQSLYISISVSISVFPVSIYLSIYLSIYHLSIYLTPSSFFFFCCCFFYRIFQIFCPPTDLKRTSVSIFHFIFHFFSLTLRIPNLCRCVYVYMFLNISLSLSLSLSLSSPFGALPPSLPPSLSLSFTHSLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E2Y3</accession>
    <name>A0A812E2Y3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_65232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004704">
        <property type="protein sequence ID" value="CAE1314247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E2Y3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="338"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="367"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="423"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="472"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="497"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1314247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="518" mass="62778" checksum="EB2A4961466E9F3C" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E3C4</accession>
    <name>A0A812E3C4_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_67626</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004896">
        <property type="protein sequence ID" value="CAE1316897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E3C4"/>
    <dbReference type="OrthoDB" id="6142965at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="543"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="651"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="259"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1316897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="673" mass="77362" checksum="3850C1682CF9D76C" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E3M6</accession>
    <name>A0A812E3M6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_63748</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004577">
        <property type="protein sequence ID" value="CAE1312538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E3M6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1312538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="169" mass="19542" checksum="E2DFAAB7E5837AB2" modified="2021-09-29" version="1">MNRECDTRKLARKSFYQSLHTKRHLSLYLSQSVHIYLSLFISLSFSLSLYLSIYLCSFSIYLSIYLSIYLSIYVFHLFISIYLSLIISLYPSKSVQIYLSIYLSIYLSIYLILHIYLSQSLHIYLSIYLSIYLSIYLHIIGGAKKNMASRGLLPSPGTDGHLLIHKVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E3V6</accession>
    <name>A0A812E3V6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_66094</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004764">
        <property type="protein sequence ID" value="CAE1315149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E3V6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1315149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="239" mass="27514" checksum="7A82E4DC9C2355BA" modified="2021-09-29" version="1">MFLFSLFSFLFPSGFFLFFSLSHKFLSHSLFHSFPPMPSLSVIIFIFSLVSHSLSFSPIFFHFLTPFLTLSLFLAFFFLSSPAQSLYFFLSFFLSFFLSLSDSIYFLHTFFFTFSLILFHVNLVSRSSFLYLVSPLYSTSFLCPFFFLLRHFSHSIILSLPLSLPSFLFLAFFLCFSSPVSITIFLSLFSRSGFLFYLSHVLSTSLTHCLSFTLSLSLSLSLIHALSLSLSQFWCVIVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E7I7</accession>
    <name>A0A812E7I7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">SIK2</fullName>
            <ecNumber evidence="10">2.7.11.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SPHA_69580</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Farmed</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="10"/>
    <dbReference type="EMBL" id="CAHIKZ030005093">
        <property type="protein sequence ID" value="CAE1319142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E7I7"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050321">
        <property type="term" value="F:tau-protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14338">
        <property type="entry name" value="UBA_SIK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000156">
        <property type="entry name" value="Serine/threonine-protein kinase SIK3 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057380">
        <property type="entry name" value="UBA_SIK1/2/3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF74">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23312">
        <property type="entry name" value="UBA_SIK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="1"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="418"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="530"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="752"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="799"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="425"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="536"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="799"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="843"/>
            <end position="855"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAE1319142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1043" mass="115778" checksum="08939F8D7B7011B8" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E9B5</accession>
    <name>A0A812E9B5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_70150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005131">
        <property type="protein sequence ID" value="CAE1319839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E9B5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1319839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="256" mass="30306" checksum="2D0DA2E98A6712F5" modified="2021-09-29" version="1">MKNTSIYLSIYLSIYLLSIYLFHSVNIYLFYLSIIYPISFSYLSIYLILLIDHSSIYPFISIYLYLSIYLSIYLSISIYLFHFVNIYLSNSVIIYLSIYLSIYLSIYLSHSVNIYLSIYLSIYLSIYLFHSVNSLFTPITLLLRIYPSPAYLSIYLSIYLSIYLSIYLSHFVNIYLSNSVNIYLSIYLSIPFCYYLSIYLSIYLSIYSILLISIYLSIYYHLSIYLSISKIILLHIIISIYLSIYLSIYLSHLSIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E9L3</accession>
    <name>A0A812E9L3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_71044</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005201">
        <property type="protein sequence ID" value="CAE1320824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E9L3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="374"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="403"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="429"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="453"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1320824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="475" mass="55164" checksum="211E32BA851E259B" modified="2021-09-29" version="1">MDTGMSSHFPFVLPSRNSTNIFFAAICFLPCCFSTHWTLKKNFFSSFSPTMFLDTSSRFSLFFFLFLFFMFFSSLIRLSFSIFLSVFLIISFIFFAFLFLFNVFSFFSQIFGFSIFLFSVISLSFFFSHFFIHFDLLKMDNSAIFAVSRGGSDAGRVCVRGRRAATTPKTISSAAGIQSFFFFSSFHRHHHSFSPPCEHCPRLFHHRLGLAWPYTRVLSVKPKSSIISGILLTQMMKLFKHLSIYLSIYLFISIYLSIYLSIYLSIYLSIAVCSLSIYLSMYVLLPVNDYFHHYYYYLNPFISIYLSIYLSIYLSIYLSIYLSLFISIYLSIYLSISVCSYLSIYVSIYLSLFVSISSVHYLSIYLSIYHSLTYLFWLSATKGFLLDYSIVRIMMRLSLSLSSLSLSLSLSLLFIIYLSIYLYQSVHYLSIYLSIYLSIYLSICLSEPDHNTIYLSIYLSIYLSISGFSLSMDAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EAZ1</accession>
    <name>A0A812EAZ1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_70324</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005144">
        <property type="protein sequence ID" value="CAE1320041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EAZ1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1320041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="257" mass="29930" checksum="CA82373C4B61B2CD" modified="2021-09-29" version="1">MRDRLLLFSFFCYLYPAIGAYISYINITICVGIRDLLFFLFPLLLLLLHLLLFHLFLYLLLFFSYPSFFLSFSILQLVLILFILISQFVWLDMRDLLLLLPPPPPPRLLSFLFSSFFYFNPTISAYIIYINITICRVRYQVFSFSSSSSSSSPILLLLLLLLLILSFFFFPSPPHSSSSSSSSSFPLLRILLLLLLLLLLLLLSLSFAFFFFFFLLFGNSLLLLLLLLMSINSRKMYMYLICLSLHILVMKPSFSSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ECA0</accession>
    <name>A0A812ECA0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_71731</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005255">
        <property type="protein sequence ID" value="CAE1321670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ECA0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1321670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="219" mass="25403" checksum="BBFE8836995A3E2C" modified="2021-09-29" version="1">MDASFFISFYLSIYIIFIYLSIYRSIDVSMPPVHFYLYIYLCKSIPIYSYLSMDESFFISIYLSIYLSIYLSMCQCQSVPIYLSIYLSIYLCVNASLFLSIYLSIYLSIYLSIDVSMPVCSYLSIYLSIYLSIYLSIYLSIDVSMPVYSYLSIYLSMCQCQSVPHLSYLFIYLSIYLSICVNASPFLFIHSSIYSSIYLSIYLSIYLSLFLSSHVSASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EDN5</accession>
    <name>A0A812EDN5_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">glycerol-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="5">1.1.5.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SPHA_71630</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Farmed</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Polyol metabolism; glycerol degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.5.3" evidence="5"/>
    <dbReference type="EMBL" id="CAHIKZ030005246">
        <property type="protein sequence ID" value="CAE1321557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EDN5"/>
    <dbReference type="OrthoDB" id="264015at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004368">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.870:FF:000001">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.9.10:FF:000001">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.870">
        <property type="entry name" value="Alpha-glycerophosphate oxidase, cap domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031656">
        <property type="entry name" value="DAO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038299">
        <property type="entry name" value="DAO_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000447">
        <property type="entry name" value="G3P_DH_FAD-dep"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985:SF15">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16901">
        <property type="entry name" value="DAO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01001">
        <property type="entry name" value="FADG3PDH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00978">
        <property type="entry name" value="FAD_G3PDH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="687"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="711"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="743"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="781"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="812"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="15">
        <location>
            <begin position="581"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="15">
        <location>
            <begin position="617"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAE1321557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="854" mass="97731" checksum="B1D140828D4ACE80" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EID5</accession>
    <name>A0A812EID5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_76055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005479">
        <property type="protein sequence ID" value="CAE1326463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EID5"/>
    <dbReference type="OrthoDB" id="3938623at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1326463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="375" mass="41989" checksum="3134CC2092B4505B" modified="2021-09-29" version="1">MPVGDRFSHIVPQFSVNPTLYNPPSGDSLLPRAHPAFPKPRVPASYGDFFRTLSAPYSMWWMKYAPTMTANYNLNHLSRNPFDMASQVAQPWPANIKRMREPTTSSDESEYKYNGFKMPDQWNGFTFMQPTRTLYTESGTTEKEEVGGSGSPRSQKYAGNETAVDACDYSNNIRDSPDVENVASPNLSDASSNDGVQDHVGPREKYARREHDAADVSSTSSYGPPSPSIQAVETCKQILTDDQQTMVDDKEMGKQCQSSRLLSDEQPLSDGELESIATDNMDLEHISVEKLRNLLTKAKKLKKKAAQNRKRLRCTFEEYYSKEEEIIKDKRPKPVNTKESRDPVNALCSKMAVGERCPKMSAAEMAGAIVNANRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EKN9</accession>
    <name>A0A812EKN9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_76277</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005487">
        <property type="protein sequence ID" value="CAE1326754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EKN9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1326754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="221" mass="25500" checksum="2DD4BEA50400897F" modified="2021-09-29" version="1">MIYLSIYLSIYLSIYLSIYIYIHIYVTIYLSIYLSIYLSIYLSIYLFPVPIYLSIYLSIYLSIYLYIHTYIHTDSSQGALAAVSIDKLNCIPKPLPTDWTDVASSIPTKHPITEEDATLDPLRTIPFQSARPSGALPDFSFPTASAGVVVLTVAPLDQQWGRHPSTFTGTARLHRFFDTGSLVVVLCFFFFFFFFFFFFFFFFFFFSFSSSFSFSSSFYVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ELV0</accession>
    <name>A0A812ELV0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_73277</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005370">
        <property type="protein sequence ID" value="CAE1323356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ELV0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="308"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="330"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="359"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="388"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1323356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="407" mass="47888" checksum="718553D30F0BD2C3" modified="2021-09-29" version="1">MTKTQDEDTKFFSFSLSFLSSFSLSFISEFFTTSHSSFPPFFVYSFIPFFILSFFLFAILAFSFLLFLPISSPSFLFSFFFIILFPLLSVFLPFLHYFFLYFSFSLFLFLFPLSFLYSFSSFSFLFLHICLLPLFLYYTLSFQGCPKFSFCLSIYLSIYLSIYLSQSVHIYLSIYLSQSVHIYLSIYLSIYLSIYLSHSGHIYLSIYLSIYLSIYLSISVCSYLSIYLSIYLSLYISIYLSIYLSIYLCISLFISIYLSISVCSYLSIYLSIYLSIYLSIYLSHSGHIYLSIYLSIYLSKNTLKRSHLSIYLSIYLSIYLSIYLSDSVHIYLSIYLSIYLSIYLSLFISIYLPVHIYLCISLFISIYLSIYLSIYLSIYLSISLSQSVHIYLSIYLSIYLSIYLLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EQ74</accession>
    <name>A0A812EQ74_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_77318</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005514">
        <property type="protein sequence ID" value="CAE1327907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EQ74"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
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            <end position="51"/>
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            <begin position="88"/>
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            <begin position="143"/>
            <end position="168"/>
        </location>
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        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="280"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1327907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="308" mass="36408" checksum="0EC48123368568A6" modified="2021-09-29" version="1">MECQVIISTSIYLPHSRYIYHFLSIYLSIYLSIYLSIYLSISIFITFFLHLSVFSTSIFFPLYLSIYLSIYLSITFYLYHILSTSICFLYIYLFPTISIYLSIYLSIYLSIYLSIYHFLSTSMYVCTYLSIYLFGFLSNSNNIYLSIYLSVYLSIYLSICIDFMYIFINLFHSLSIYQSIYLSIYLSNSLRIYLSIYLIFSTDIHLSNSLRIYLSIYLSIYLSIHLSIYLSIYLSIYPSNSLRIHSSIYLILSIYLSIYPSIYLSIYLSIYPSNSLHLSIYPSISLRIYLSIYPSIYFSPYPSIYLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EQ78</accession>
    <name>A0A812EQ78_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_78066</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005528">
        <property type="protein sequence ID" value="CAE1328408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EQ78"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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            <end position="27"/>
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    </feature>
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    </feature>
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    </feature>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1328408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="261" mass="31422" checksum="901411AB5ADDA357" modified="2021-09-29" version="1">MYFSYFFLPYFSTVLFYSLSYVSLSFFLSCFLSFFLYLFISFFPAFFLPLFLSFFLSVFPAFFLSFFLSFFLSFFLSCFLSFFPALLLSFFLSFFLSFFLSFFLSCFLCFVFFFLSFFLSFFLSFFSFFLSFLFLLSFFLFFFLSFFFLSFFFLSFFLFLLSFFFPALLLSFFLFFFLSFFLPFFIFSTLILLLFFFFFTYLPNSIFLYVFSTHSVTLIFLHPLPSCITVPPYCSLSFSSFSPLTILHISSLILPIFFLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EQN0</accession>
    <name>A0A812EQN0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_79118</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005558">
        <property type="protein sequence ID" value="CAE1329699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <location>
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        </location>
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        </location>
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        </location>
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        </location>
    </feature>
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            <begin position="775"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        <source>
            <dbReference type="EMBL" id="CAE1329699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="799" mass="90187" checksum="737F74323E7D0ACA" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ESA2</accession>
    <name>A0A812ESA2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">SPHA_76580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005493">
        <property type="protein sequence ID" value="CAE1327023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="1421090at2759"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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            <end position="239"/>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAE1327023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="314" mass="36722" checksum="32EF8C4C7736CE14" modified="2021-09-29" version="1">MLLRLYRVSIYLSIYLSIYLSIYLSIASRIAIFSISIYLSIYLSQAVHIYLSIYLSQAVHIYLSIYLSIYLSIYLNLFISIYLSIYLSISICSYLSIYLSQSVHIYLSIYLNLFISIYLSIYLNLFISIYLSIIVCSSIYDIYHSLFIYLSIYFSLFIYLSIYFSLFIYLSIYFIVSHLLIDRIYLSIYLSIYLNLSQSVPIYLSIYHNLFISIYLLNYAVAPSIYLSIYLSIYLSIYLSVSINEREKTSIHTLSLYSSLSPSISLFSFSLSRSFFLSLSLSLQNAVLVFEIVTRRTFLFHSFFLSLAPNDKDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ETG2</accession>
    <name>A0A812ETG2_ACAPH</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <organism evidence="2 3">
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        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
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        <lineage>
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            <authorList>
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                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
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    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ETG2"/>
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
    </feature>
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    </feature>
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    </feature>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="771"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="805"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="836"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="882"/>
            <end position="903"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1330247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="925" mass="111030" checksum="7AD4106B90C34208" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ETY8</accession>
    <name>A0A812ETY8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_79370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005566">
        <property type="protein sequence ID" value="CAE1330033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ETY8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1330033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="157" mass="18344" checksum="7C630F0D1C2DDD41" modified="2021-09-29" version="1">MPEQTISVLQRSHANTELTRRRRERRSVIPLIFPILVFSFFLSFFFLSCFLSSTNVSFLPSSYKLFFFFFFFSFSFILAFPSHFLHLYFPLAFLFFLSFFLSFFFFLSFILSFNSSSSSSSSSSSSSSSSSSSSSVRISFFLSILLFCRTFKLFTFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AIV8</accession>
    <name>A0A812AIV8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_226</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000002">
        <property type="protein sequence ID" value="CAE1138276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AIV8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="112"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1138276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="303" mass="34526" checksum="AC2BE1CE56F6B85B" modified="2021-09-29" version="1">MSINWLVEKVIIYYKTTEVADPILGAHNDAELYELQWWCRKFHCLIGLVILIFASWHYSDINAENNVLLKQIQDFLFNARYRRRVSAVDHLSPEQSQQKEPDIQNGNSSTGYESDSSVSSHTSYVNESSDATYTLNDADSVSTISSHSSWMSLRQELCELDEEAAENEANRLSSPSTSRSNQIYSSTPLRRAPVHMARSADHRYNLRPRTTNNSFNSTKSLTLIDSGIFFLDKVCRRTFHGTACVILTVTGRKSNLIVYSLNSHLASLNFVQHFRTPHHFLPSFVYTGPSLIFFFFFPVNCAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AJH2</accession>
    <name>A0A812AJH2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_95</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000001">
        <property type="protein sequence ID" value="CAE1137485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AJH2"/>
    <dbReference type="OrthoDB" id="6819399at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134">
        <property type="entry name" value="OS08G0543275 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134:SF5">
        <property type="entry name" value="OS08G0543275 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="297"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="346"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1137485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="372" mass="43058" checksum="33CB1878E48FC0F7" modified="2021-09-29" version="1">MYKHVSFRPLSSFSFHFSYELSKEGRRINRLKPCDTDPNKNGFNCRISLSVHIYLSIYLSISVCSHLSIYLSQSVHIYLSIYLSLFTSIYLSIYLSIYLSLFTSIYLSISVCSHLSIYLSLFTSIYLSQSVHIYLSIYLSIYLSQSVHIYLSIYLSIFLIFHIYLSIYLSQSCSHLPDLSIYLSLFTSTYLSIYLSQSVHIYLSIYLSQSVHIYLSIYLSILSLFTFIYLSIYLSQSVNLISIYLSISVCSHLPIYLSISVLFSSSIYLSQSVHIYLSIYLSISVCSHSSIYLSQSVHLSIYLSLFIYLFIYLSQNVHSYLSISVTSLFLYLSQSVHIYLSIYLSLYISIYLSIYLSLFISIYLSLFISIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ALW7</accession>
    <name>A0A812ALW7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_1596</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000045">
        <property type="protein sequence ID" value="CAE1145222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ALW7"/>
    <dbReference type="OrthoDB" id="8040188at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1145222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="211" mass="23883" checksum="BA5D9977883A7C0A" modified="2021-09-29" version="1">MPAPTSDARNSEGPQTRANRPRVATNMADVRLSQTPQARRIRLDGDIQRLAAARGIAYPSSSFWSFLAFNYDPGINLTTRDNINVGSLTRVCQFCNARKWAGDPAGLCCSSGKIRLSMSKFLHLYFIAENNLQAKTWIGILPPSGRVSRRDVILLLQAMLHEFNSYIRSFKYTLEYAPFPSFRIVIDADKRLQCSCVQRSGRYYTWGARLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812APQ9</accession>
    <name>A0A812APQ9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_3035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000088">
        <property type="protein sequence ID" value="CAE1150789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812APQ9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1150789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="188" mass="22252" checksum="181D8162A89B9B51" modified="2021-09-29" version="1">MGHSLFPLKHHSLFLVKSHSLFLLKGHFLFFVKGHSLFLASGQIKSIYLSIYLSIYLSIYLSIYLSLLLCSYLSIYLSIYLSIYLSIYLFLLLCSYLSIYLSIYFFYFVHIYLFIYLFLLLCSYLSIYLSIYLSIYLSIYLFLLLCSYLSIYLSIYLSIYLSIYLSVCFSLFLLVFIILLIKDTLYTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812APS0</accession>
    <name>A0A812APS0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_2058</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000058">
        <property type="protein sequence ID" value="CAE1147057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812APS0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="307"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="336"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="374"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="413"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="469"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="497"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1147057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="519" mass="62152" checksum="F911B71BAFECDF4A" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AQT3</accession>
    <name>A0A812AQT3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">SPHA_2610</name>
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    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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            <taxon>Decapodiformes</taxon>
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            <taxon>Sepiina</taxon>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AQT3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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            <end position="98"/>
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        <location>
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            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1149065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="204" mass="21762" checksum="3332E2BFBBE59075" modified="2021-09-29" version="1">MMSLLANAQICVSPSSLLGILPWPSPSSGHLIIAISFQRREKSSAFPAIPSRPLLLSHLTKTTDARCFPSQGRGPPIPPPDTYGPMCNPTPAPASPGDVLSTPLSPSTNPHCYLLDGHLINPTSVCTGTESTRPIVHGLILFIEILGFPPLSDLILAQFLLPLIVFGVGTEVSRPLPSTHSFPHFRKTSSLTPEPRHTGLSSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AR58</accession>
    <name>A0A812AR58_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_3678</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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            <taxon>Coleoidea</taxon>
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            <taxon>Sepiida</taxon>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
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                <person name="Bekaert M."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
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    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="protein sequence ID" value="CAE1152997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="9635126at2759"/>
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            <end position="306"/>
        </location>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1152997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="309" mass="37001" checksum="25A4741EFFFCBFE4" modified="2021-09-29" version="1">MSREEEALAIQGGISHAELFLSSCSFFFRLICCGMLPTRSCASLSLCHLPMFLHIYLSIYLYRFLHIYLSVYLGFFHIYLSIYLSIYLGFFISIYLPRKPQTAVSYLSIYLSIYLSIYLSIYLSIYLSFEDFISIYLLKTLHIYLSIYLTIYLSIYLSIYVSSYLFFFLHIYLSIYLSIYASSSIYLSIYLSIYLSICLSRLFISIYLSIYLSIYLSIYVSSYLFFFLHIYLSIYLCFFIYLSIYLSIYLSRFLHLSIYLSIYLSICLSRFLHIYLSIYLCFFIYLSIYIYIYIYFFISIYLSIYLSMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ASN0</accession>
    <name>A0A812ASN0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_3936</name>
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    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
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        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">Farmed</strain>
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    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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            <begin position="229"/>
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            <begin position="287"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1153580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="325" mass="38063" checksum="84C1FD613D54C72C" modified="2021-09-29" version="1">MRFLSLYSIVFFFYLIYNFFFLFLPFLLFLPSFPLCFLLSPTLSLPQSLSFPLQFFLSSIFPFITAMLRQASCLSISAHFISIYLASYQFVHIYLSICSNLSVCSYLSIFPSVSSYLSFHQFLHIYLSISFFISIFPSVSSYLSFHQFLHIYLSISFFISIFPSVSSYLSFHQFLHIYLSISFFISIFPSVSSYLSFHQFLHIYLSISFFISIFPSVSSYLSFHQFLHIYLSISFFISIFPSVSSYLSFHQFLHIYLSISFFISIFPSVSSYLSFPSVSSHLSFHQFLHIYLSISFFISIFPSVSSYLSFHQFLHIYQSVSFIHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AU66</accession>
    <name>A0A812AU66_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">SPHA_5747</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
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    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <dbReference type="EMBL" id="CAHIKZ030000189">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AU66"/>
    <dbReference type="Proteomes" id="UP000597762">
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    </dbReference>
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            <begin position="30"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="243"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="363"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="391"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="420"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="444"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1158968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="462" mass="56243" checksum="ACBCBAA1B0E0DD65" modified="2021-09-29" version="1">MPHPVTRPGERNSELTLSYESIFHVPRRSFFSFIGVSLYYSISPIAILRRLFPLSSSIYLSIYLSIYPIDLFVLIYLNAFGQMVIKIFYSHLSIYLSIYLSVCLSTVHIYLSIYLSIYLIPFTSIYLSNFLCIFFFLHFIISLRNINTHLSFFFFLLSSLPFFLSFFFFLSFFLYFSIPLLISFFISFFLFCFLSFFLSFYFFSFFNYIFFLSFILSFFLTFFLSVFLSFNNSFFFLSLFQRFLSFYISFCFLSFFLYFFLYSFSFFLTMIPFSFFPSFFLSFFFLPMIPFSFFLSFFLSFFLYLFIYFSFILSSFLPMVPFSFFPSFFLSSHDSFFFLSFFLSFFLSFFLFHSFFFSSHDSLFFLSFFLSFFLSFFLSFFLLMIPSYLSFYISFIIFSFFFLSFFLSFFLSFFHTFFQIFLYFFVYFLLPFLFLSFFLSFFHAFLFSFLLDIIISFFYFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AUI0</accession>
    <name>A0A812AUI0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_5956</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000196">
        <property type="protein sequence ID" value="CAE1159454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AUI0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1159454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="319" mass="37818" checksum="ED1470257605B10C" modified="2021-09-29" version="1">MIEYCNTSSPPLHTLSDFFIYLSISDSFPPALFLFLSFFSLSLFFFLSLFLSFSLVRFLSLSLSLFFSDIQARAHTYARIKWAAFSLHSKHSKLMASCQVTNQQAFVVFIPKHLFHDAFSYTNSFLFSFHHNTPFLSDFLTHFYVALRSLHSFFLSFYLSFFLSYVPFQQCLFIFPYLPFFVSLPSFLSFFLPNHIPFPFNNSLFITISYSSFFFPNFFIPSPFPSFLHLFLYSILLPFSFINFFFFFTLFFLCSFPPFFFIYSTLSQFLLLSHFLLFLFLDIFFLSFSFFLSLFPYFLISFFFSFVFSPLSLLLSSYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AVZ3</accession>
    <name>A0A812AVZ3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_6245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000205">
        <property type="protein sequence ID" value="CAE1160079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AVZ3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1160079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="204" mass="24502" checksum="20429CF0319F25FC" modified="2021-09-29" version="1">MFLTLFQRYFKSFILSCSLFFSTILQTCLSSLFFFLSFLPVFLSFLPVFLSLFLSCFSFLPFYKPACLPYIHLSFFLSFFLCFFLPFCKPDCQFLSFFLSFFLSFFLSFFCAFFLPFCKPDCQFLSFFLSFFLSFFSFLPFYKPACHLCHFLSFCIPCYLSFFSTILQTCLSSFFCFLSIFHYTFLYFLSFFFLTFFLSFHIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AXM0</accession>
    <name>A0A812AXM0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_6928</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000224">
        <property type="protein sequence ID" value="CAE1161627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AXM0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1161627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="152" mass="17091" checksum="8FEFA8664BE4B6AD" modified="2021-09-29" version="1">MYFKSSLQNRKSIYLSIYLSIYLSIYLSIYLSISAHLSFYVPTYLSISISVSSSIYLSIYLSIYLSIYLSISVSSSIYLSIHLSTYLSTYLSISVNSYVFLSIYLTIYQLSGHGQLLHPPWCLVCAWYPSVVAGTSSSFLDLLSVPVTSTIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AYF8</accession>
    <name>A0A812AYF8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_7432</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000238">
        <property type="protein sequence ID" value="CAE1162765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AYF8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1162765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="180" mass="21864" checksum="6C5E42979CF4477E" modified="2021-09-29" version="1">MYLYLDDLSFLSFFLHLVLLSFILSFFLSLFLLSFFLSFFIPSFLSFFLSLISFSFFLSSLSFSSICFFLFFLSFFFLHLFLSLLSFLSFLSFFLHLLFFLSSLSFSFIPSFILSFFLSTFISFFLYLAFLSFFLSFFIYFLTYFFFHPFFHSFFLSFFLHFFLSFFIYLALLSFLFFFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B0J3</accession>
    <name>A0A812B0J3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_8352</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000270">
        <property type="protein sequence ID" value="CAE1165260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B0J3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="330"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="386"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="451"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="479"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1165260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="505" mass="57567" checksum="8AFFBEA174FB564B" modified="2021-09-29" version="1">MFPSVFLSLFPLLLFYSFFHSLIDCFFLFFYPHFCFLSFSFFLILCLPFIPPSLIACLHSFLCLLSYCLRALFLLPSLFYCLLTLLFCPLFLSLLLFACSLSSTLSLLLFTYSLVLPSLSLSLIVCLYSFFHPLSFIVYLLSCFALSFSLSYCLLVLFLPPSLFIVYFSCFALSFSLSYCLLVLFLLPSLFYCLLLLFCPLFSLSLVFACTLFFHPLSFIVYLLSCFALSFSLSYCLLALFLPPSLFYCLLTLLFCPLSLSLIVCLYSFLTLSLLLFTYSLVFLSLSYCLLVLFLPPSLFYCLLTLLFCSLFLSLLLFACTLSSTLSLLLFTYSLVLPSLSLSLIVCLYSFFHPLSFIVYLLSCFCSFSFSYCLLVLFFFYPLSFIVYLLSCFALSFSLSYCLLVLFLLPTFLFALFLLPLLLFCACSFFTSPPFYIPFSSFLGCSLSTPTFLKIIFLLFCLSLSFFILLSISFSSDQLVIFIYLLGQLQFPPLIVIHGSVPFGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B129</accession>
    <name>A0A812B129_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein C17orf53</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_8657</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000282">
        <property type="protein sequence ID" value="CAE1166006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B129"/>
    <dbReference type="OrthoDB" id="21443at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000725">
        <property type="term" value="P:recombinational repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028045">
        <property type="entry name" value="HROB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058570">
        <property type="entry name" value="HROB_OB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14523:SF1">
        <property type="entry name" value="HOMOLOGOUS RECOMBINATION OB-FOLD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14523">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN C17ORF53 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15072">
        <property type="entry name" value="HROB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homologous recombination OB-fold protein OB-fold" evidence="2">
        <location>
            <begin position="217"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1166006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="371" mass="41071" checksum="3ECFBAA0C29A8C79" modified="2021-09-29" version="1">MFKIPDDDDEDDEFWKDFPLEEFENLPANKGEKRQGSPLQKSQEEYKKLCTRNIENVPVNSGLCSSILLPISNDNLPLQDVTLPHLAGISQKPGCHSENLATSPGTPENHYTKQQQQTPQSDRCPKRKFPGPAGMLPRLVPGQKLTDTVIKLDGRGDSQLQKNENLLSANPVENFFGENPWLKLVSDLGEDSSRILNSFSIKELHLKACKKQLHQGKVLLLFAILETVDLSSIDASVRLRDRTGSIQGTIHRNLVKEYGEHLQPGTVLVLKQVGVLSPNPRTHYLNITANNLVSLYSTLASGQVTVSAGCSRNGVSVSVSAGDKYRLRADNCPNTNITNPTTTIEDTSNMSDIWQDELTDDILSQLSDDLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B138</accession>
    <name>A0A812B138_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_7429</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000238">
        <property type="protein sequence ID" value="CAE1162801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B138"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1162801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="249" mass="29489" checksum="811320834375596F" modified="2021-09-29" version="1">MQSYLSQSVHIYLSIYLSIYLSIYLSIYSFHIYLKLFISIYLSIYLSIYLSIYLSGYLAIYLIYLSIYLSIYLSISLSLSIYIYIYIYIYIYIYISQFISISNCSYLSICLSVCLSIYLKLFISIYLSIYLSIYLKLSISINLSQSAHIYFLNCSYLSIYLSIYLSIYLSVCLSVCLCAREVKHGYILEDYPVYMWFISIYLSIYLSIYLSIYKTCLFLLCYNLSIYLSIYLSIYLSIYLSKIMLIPMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B2W6</accession>
    <name>A0A812B2W6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_9880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000314">
        <property type="protein sequence ID" value="CAE1168133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B2W6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1168133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="257" mass="30244" checksum="13A69D7584F40666" modified="2021-09-29" version="1">MPLTSFSSMPPSSSRFVPRYERFTHEDCGQTSLHIRSHSHYCYFCHPSYHLTPSFLSQPTTLVSNRVSIYLSIYLSIYLSISVYSYLSQSIHIYSYLSIYLSIYLSIYLSIYLSQSIHIYLSIYLSIYLSIYLSQSVRIYLSLFISIYLSIYLSIYLSIYLSQSIHIYLSIYLSIYLSQSIHIYLSLFISMYLSQSIHIYLSIYLSIYLSIYLSISVYSYLSQSVLIYLSLFISIYLSIYFVLKKIHLQNIFFKNVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B528</accession>
    <name>A0A812B528_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_10404</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000335">
        <property type="protein sequence ID" value="CAE1169059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B528"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="290"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1169059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="315" mass="37458" checksum="ED4FA01001A5739A" modified="2021-09-29" version="1">MISFKACSFLWDSSSFRKLQQLTQIYQSISVCSYLSIYLSIYLSIYLSIFTYFSQHLFFVATRLFSVRVFLCIYVFVSVPSYLSIYLSIYLSIYLSIYLSIYLSHDNRKGFDFKLCVSNGLSSYLSIYLSIYLSIYLSLYLFLYLSIFISIYIYIYLYLSIYLSIYLSIYLSIYYLSIFISAYIYIYLSIYLSIYLYIYIYIMLLSIYLSIYLSIYLSIYPRLLSLSSIYLSIYLSIYLSIYLNIKKHIYLSIYLSIYLSIYLSIYLSNKTILSNTSRYLQAFKFSEDRMINLSLSLSLFLSIYLSIYLSIYLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B694</accession>
    <name>A0A812B694_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_10865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000355">
        <property type="protein sequence ID" value="CAE1169967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B694"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <end position="50"/>
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            <end position="79"/>
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            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1169967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="245" mass="28131" checksum="AF23DF1EBA1E8C29" modified="2021-09-29" version="1">MDGQHFVHSSPKFPRAKPCKPLHQLFSDSHSLIQILSFSFIYSPILHTFYPHSLILLSSFRYSLSFSLILFILIFSFLFTHASIFSDSLFFSFPFSHCFILIRSFPHSFSFSNFLIHSLSLSLILSLSLYHSHSLIFSFTLSLHHSLILILTFSSLLVLQLSENPIDQTNMASPYLLSTLIDSDCPAKIKHRDLNLFNYVTKISQRSTETFFLTCHWEIIFPIRYSAVKTSVRGHPSTQPSSLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B9Y0</accession>
    <name>A0A812B9Y0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_13019</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
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            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000435">
        <property type="protein sequence ID" value="CAE1174193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B9Y0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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    </feature>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="439"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="475"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="514"/>
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        </location>
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        <location>
            <begin position="573"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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    </feature>
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        <location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="661"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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        <location>
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        </location>
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        <location>
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    </feature>
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        <location>
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        <location>
            <begin position="949"/>
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        </location>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAE1174193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="988" mass="120032" checksum="D57B41E938FA3B5A" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BAB5</accession>
    <name>A0A812BAB5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_13174</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000440">
        <property type="protein sequence ID" value="CAE1174606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BAB5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    </feature>
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            <end position="180"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1174606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="228" mass="27065" checksum="A10B2FD681CC2967" modified="2021-09-29" version="1">MELIDFFLFIHYRCLAFSSLSIYLSIYLSIYLSIYLSHSAYLSIYLSIAFSLAIFLIINLSINLSHTDSFCLSIYLSISICSYLSISFILNSFYLFSVFFLSFFLSFLYPFLSLFLLFFLFHSFIYLILPSIFHYSLIHLFYLLSLFKTLMHFFLSSFLSFFFPFFLFFFISLYFFYLTISLFSRPFSFFSATLSFLLFFLSFFLSLISTWSFSADTTDDTVQVERSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BCU1</accession>
    <name>A0A812BCU1_ACAPH</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_14466</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Coleoidea</taxon>
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            <taxon>Sepiida</taxon>
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            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000494">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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            <begin position="196"/>
            <end position="220"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1177062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="235" mass="28785" checksum="38B10AB5165DA02C" modified="2021-09-29" version="1">MIFSLSSSFFFFSISFFHHLFSRSVLSQNFKANHFYSFFLISLSSSSFFHHLFFSVCFIRNFKLLSLFLLFFILFFILFFVFFVFLLFSFSSFFFFFFFLFLLFCFSSFFFFFFFLFLFLFLLFSFSSFFFSSFSSFFFFFFFLFLLFSCSSFSISVFISSSFATLSNLFPVPFFFFFSSFYSLFFNLFHPKNFRMFFLIFFSFFFFIYLFSFSILLLSFPFPSVFLRLLSIFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BD71</accession>
    <name>A0A812BD71_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_13496</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Mollusca</taxon>
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            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
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            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
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            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000454">
        <property type="protein sequence ID" value="CAE1175188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BD71"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
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        <location>
            <begin position="51"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1175188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="231" mass="27478" checksum="01244B238CB40021" modified="2021-09-29" version="1">MLTYLLFQTCDNRLINTRKHAYRYKHIYLHAYAYFTEKVILSLKQRPSISWFPLTILSLFLFPPPLYTVYRFLSLPFAPTNVVFDWLSFFFFYYFIETQQLLSLSLSPSFTLSKNSCCTLEGSTPCNWIHGQYEDMQGQYHSQDGADHILHGVICWTIMVSCDRQQEGTRRYCHHRRNSHLSIYLSIYLSIYLSIYLYTHTRGLSLFFFFSLSLSLTHTYTHLFSSLSLYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BDA9</accession>
    <name>A0A812BDA9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WDFY3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SPHA_15283</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000530">
        <property type="protein sequence ID" value="CAE1178572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BDA9"/>
    <dbReference type="OrthoDB" id="10018316at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06071">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01201">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051944">
        <property type="entry name" value="BEACH_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023362">
        <property type="entry name" value="PH-BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46108">
        <property type="entry name" value="BLUE CHEESE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46108:SF4">
        <property type="entry name" value="BLUE CHEESE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14844">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51783">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="866"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="892"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="962"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="domain" description="BEACH-type PH" evidence="6">
        <location>
            <begin position="484"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="domain" description="BEACH" evidence="5">
        <location>
            <begin position="637"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="441"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="465"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAE1178572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="999" mass="114325" checksum="38D5E26B4BF88EDB" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BDC1</accession>
    <name>A0A812BDC1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_15411</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000535">
        <property type="protein sequence ID" value="CAE1178740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BDC1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1178740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="554" mass="62341" checksum="F2F1A456A51B9655" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BFA2</accession>
    <name>A0A812BFA2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_16423</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000577">
        <property type="protein sequence ID" value="CAE1227519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BFA2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1227519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="343" mass="40034" checksum="3948E07AA8E4F65A" modified="2021-09-29" version="1">MSRWGMFSNTVRQLARGTADVIRFRFFSPISFHLSLSTSLFPPLTYHVSLSTSLLSYLSLLLSLSTTLFPPLFIYLPLSTTLFPPLSFHLSLSTFLFPPLSLSTSLFPLLSDCIISLSTLIYLSIYLSIYLSIYLSIYTYRFFISIYLSIYLSIYLSQAIHIYLSLCISIYLSIYLSIYLSIYLSLYLSIYLSIYLSIYIHIHSFFLSSFLSFFLSLSILVPSLHVFFLYFYSFFLYLLISFLTLPLFFLSFFLFIISFSAYILCFFLSSTIFFLYLYSFCFSFSAFILPFFLSPSLFFLSPPLFFLSFFLSFFLSFFLSFFLVHSLNLRTTTCTSSFSLFHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BHD1</accession>
    <name>A0A812BHD1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_18651</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000672">
        <property type="protein sequence ID" value="CAE1232673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BHD1"/>
    <dbReference type="OrthoDB" id="6156386at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004245">
        <property type="entry name" value="DUF229"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10974">
        <property type="entry name" value="FI08016P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10974:SF1">
        <property type="entry name" value="FI08016P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02995">
        <property type="entry name" value="DUF229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1232673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="390" mass="44881" checksum="E93BFB662666377B" modified="2021-09-29" version="1">MRCHILFLKFFFCFKQFPSSLHPVTFSFIHSLSACKISLSLSLSLPYIPSLFLVLASFFCTLTNHFSVLYFLSFGELRLPSFFVSAARPSGRKRLNDDLQPFSFMPRTGKCGPSFSQICLPLLFLCKMSGNLYRKTTNQNVFLVLLDHGSRFGKFRSTYLGKLEERLPFMFLLFPKWFIQRYPEIDKVLKINSYRLTTPFDIYETLVDILYFDGKVQKATIKDRGISLFHEIPEERSCNDASILPHWCTCLQRIPVNTTDVIVEKIALSFVNRINKMTHHVQKKCAFLQLKTVKEAAKMIATDKILRFQKSLNDVLNQQVFYGNRVDAIVDYQLTIETTPGGAQFETTARYDEQEGTFTLMEEVSRVNSYGSQSSCIDILALKMYCFCGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BJJ1</accession>
    <name>A0A812BJJ1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transmembrane protein 104</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SPHA_17238</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TMEM104 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000612">
        <property type="protein sequence ID" value="CAE1229296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BJJ1"/>
    <dbReference type="OrthoDB" id="294541at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16189:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16189">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 104-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="230"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="267"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="296"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="392"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="13"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAE1229296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="447" mass="50966" checksum="284385703A0AF658" modified="2021-09-29" version="1">MPGELTETGSQYSSWVGLIYIFNLIVGTGALAMPKTFYSAGWLMSTVFLIVLAFFSYLTVTFVTEAMGVANFKVKMTRKHSTHKKDLITYEPSEDSPLIEEDTSINRETENAYMFAVTERTEMGQMASMFFNKVGVSAFYFCIIIYLYGDLAIYGVTVPKSIRDIACTYQLNNETKCNRTLKDHDPCWPSLNLNRWHSYQIFIILFALCLGPFTFFNIQKTGLLQIFTSVFRWTSFIIMIVLALLRLSKGEGKGKPATADFTEIPSLFGVSSIRLCVTILYLVSDTNQNKSHIFRLFTGDYILALIFYALLSFTGIFAFQHIEDVYTLNFLPNPCEDSKTAITNIKFIEYFLVLFPVFTLSSNFPIIAVTLRNNLKTLFFNKNRPFSWFVDRIVFPLLALLPPLSIALVTDRVDFLVDGPFIISFSKTNKVILFRSVFSSLFQFVIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BJR4</accession>
    <name>A0A812BJR4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_17913</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000642">
        <property type="protein sequence ID" value="CAE1230908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BJR4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1230908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="233" mass="28446" checksum="66B289A6E8DC3D1E" modified="2021-09-29" version="1">MEMANITACIYGWFLFNDYNYLSFFLSLSFLSLSLCNFLRFPYLTHHSSSTPSNIYVRYIFYPPLVIHIFSLFSFLIFSFFFFLISSLFAFSLFFLTFSLFFLIFSVFFDLSYFLFFSYLFFSLLSLILTPLFFSYFLVSLPYYIFSLLCFLRFSLLCFFIFSLLCFLIFFSFFFFFFSLISSFLCFFHIFFFLCFFLLSYFFFFCFFSLFFFLSSFLMFFSSLLFFFSFAFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BMB5</accession>
    <name>A0A812BMB5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_18164</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000655">
        <property type="protein sequence ID" value="CAE1231560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BMB5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1231560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="205" mass="23244" checksum="BA494DE94BFB417B" modified="2021-09-29" version="1">MLTSSIYLSIYLSIYLSIYLSMSVCSYLSIFVSLFISMSVCSYLSIYLSIYPSIYLSIYLSIYLCHLFITLSLYLSIYLCQSVHISLSLSLSISVCSYLSIYLCQSVHNSLSLYLSIYVSLFITLSLYLSMSVCSYLSLSLSLYLSIYLSIYLSIYVSLFISLSLSLSIYLSMSVCSYLSLSIYLSIYLSIYLSISVCSYLSIYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BMM2</accession>
    <name>A0A812BMM2_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Iduronate 2-sulfatase</fullName>
            <ecNumber evidence="15">3.1.6.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Alpha-L-iduronate sulfate sulfatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">SPHA_18890</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">Farmed</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Lysosomal enzyme involved in the degradation pathway of dermatan sulfate and heparan sulfate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Hydrolysis of the 2-sulfate groups of the L-iduronate 2-sulfate units of dermatan sulfate, heparan sulfate and heparin.</text>
            <dbReference type="EC" id="3.1.6.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="14">Monomer. The 58-kDa mature form is composed of two chains resulting from proteolitic processing, the 42-kDa chain and the 14-kDa chain that remain stably associated and form the 58-kDa intermediate form which is enzymatically active.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Lysosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the sulfatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.6.13" evidence="15"/>
    <dbReference type="EMBL" id="CAHIKZ030000682">
        <property type="protein sequence ID" value="CAE1233243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BMM2"/>
    <dbReference type="OrthoDB" id="96314at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043202">
        <property type="term" value="C:lysosomal lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004423">
        <property type="term" value="F:iduronate-2-sulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901136">
        <property type="term" value="P:carbohydrate derivative catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16030">
        <property type="entry name" value="iduronate-2-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000027">
        <property type="entry name" value="iduronate 2-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035874">
        <property type="entry name" value="IDS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45953">
        <property type="entry name" value="IDURONATE 2-SULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45953:SF1">
        <property type="entry name" value="IDURONATE 2-SULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 20" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0458">Lysosome</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 18" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032551486" description="Iduronate 2-sulfatase" evidence="18">
        <location>
            <begin position="22"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase N-terminal" evidence="19">
        <location>
            <begin position="28"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00050460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00056350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00062513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00066413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00068336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00081076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CAE1233243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="627" mass="71363" checksum="D634E6614E97E4BC" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BSP4</accession>
    <name>A0A812BSP4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_23278</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000861">
        <property type="protein sequence ID" value="CAE1242394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BSP4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="312"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1242394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="346" mass="41963" checksum="46D319777586A762" modified="2021-09-29" version="1">MFLLSIFIFLSHSPIRVLRVFFMSNRKLKTVEQNKIHHILFTFIYSIYLSIYLSIYLSHSANIPLPHSILTSFPFCLSFSLFYESGTVELKPSDGVGWGTNAVKLQVPCIHRDINRAHITVRRFSLFIYFLLLSFVHYFSLPCLSLMLHFCLFFVKFLLSCANFFFIFILFSPGFILVTHIFYSNFECYFAYFLHFSFECFLSGYFKFFYYLPLFLFLFFFAFFLFFLSFFLFFSSFLSFISLLNSFFCDFFHRFFHLLLFFIFSFFFLSFSFFFFFSPFSYYYSFFFLYSFFFLKCLFLLFYLLSFSDFFISYFLISFFLFFSAFFSFFLSSIFFISIFLPGFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BX41</accession>
    <name>A0A812BX41_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RanBP2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SPHA_25690</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000973">
        <property type="protein sequence ID" value="CAE1247474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BX41"/>
    <dbReference type="OrthoDB" id="6288762at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.10">
        <property type="entry name" value="Zinc finger, RanBP2-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46253:SF1">
        <property type="entry name" value="TAB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46253">
        <property type="entry name" value="TGF-BETA-ACTIVATED KINASE 1 AND MAP3K7-BINDING PROTEIN TAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00641">
        <property type="entry name" value="Zn_ribbon_RanBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RanBP2-type" evidence="6">
        <location>
            <begin position="155"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="112"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAE1247474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="187" mass="21455" checksum="5455814767B0B300" modified="2021-09-29" version="1">MAQRSATLFNSIRVCSSDGVQMPRPRNGSLQEDSDYTNALITHQRLRDKKACYSKRNFPTELDVLELRHSIESLRLEIDTMTMELDTHNNGLTPIGILDPLEQQHFYKNMNTGQSGSIFATPQSPQSWNNPPPRPPRYKPESHPVPPSIPDNELVEDTWNCSECTYMNHQALDKCEMCEFPRKHKAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BXK6</accession>
    <name>A0A812BXK6_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Small nuclear ribonucleoprotein G</fullName>
            <shortName evidence="9">snRNP-G</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SPHA_24516</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Farmed</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Plays a role in pre-mRNA splicing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000914">
        <property type="protein sequence ID" value="CAE1244891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BXK6"/>
    <dbReference type="OrthoDB" id="2146at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043186">
        <property type="term" value="C:P granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034719">
        <property type="term" value="C:SMN-Sm protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097526">
        <property type="term" value="C:spliceosomal tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005689">
        <property type="term" value="C:U12-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01719">
        <property type="entry name" value="Sm_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000017">
        <property type="entry name" value="Small nuclear ribonucleoprotein G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044641">
        <property type="entry name" value="Lsm7/SmG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034098">
        <property type="entry name" value="Sm_G"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553:SF2">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="84"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAE1244891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="187" mass="20742" checksum="DC31247438F23494" modified="2021-09-29" version="1">MHCDASAFTWGLSVSISCRFGTASLAAASIPIPLNFQRGSSGMSLISDTEGSWQDSSHPSLLHFGIDKRSKELTSGVLSTMSKAHPPELKKYMERRLSLKLNGGRTVSGILRGFDPFMNLVIDECVEETKSGERNPIGMVAVRGNSIVLLEALDRVFHTTTGMNLKKGFSHYHRYEFEKRFFTLPQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BXX5</accession>
    <name>A0A812BXX5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Reflectin, reflectin 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">REF9.2</name>
        <name evidence="1" type="ORF">SPHA_28885</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001140">
        <property type="protein sequence ID" value="CAE1254311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BXX5"/>
    <dbReference type="OrthoDB" id="3937590at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1254311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="285" mass="37816" checksum="6802468B0726CD85" modified="2021-09-29" version="1">MNRYMNRFRNWYGNNYRGRYRGMMEPMSRMTMDFHGRYMDSQGRMVDPRYYDYYGRWYDYDRYYGRPMFNYSWMMDGDRYNRYYRWMDFPERYMDMSGYQMDMYGRWMDMQGRHCNPFRHWWHQRHGYYPGFHYGSNMFYPERWMDMSNYSMDMQGRYMDRWGRHCNPFSHFYNYWNRYWNHPGYYNYYYMYYPERYYDMSNWQMDMQGRWMDMQGRHNNPYWYNWQGRHMYYPYQNYYWYGRWDYPGMDYSNWQMDFQGRWMDMQGRYMDPWWWNDYYYNYYYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C0Q6</accession>
    <name>A0A812C0Q6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_27657</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001079">
        <property type="protein sequence ID" value="CAE1251716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C0Q6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="273"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="309"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="343"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="370"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="415"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1251716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="483" mass="56156" checksum="059E92D3A1D1B10B" modified="2021-09-29" version="1">MLFRICEFFFFFLSFLSFFFSFFFFFFFSSSFFFFSSSSSSSLPSSFSLPSFSPHSSSSSSLLLGSSSLFGWHPEVGKLTQNGSSLSVVNAMCVLSIVLFFFIICSLACSHSRFNFHLSFIKRILPNASASVLAVYVDVVACLFFVCAGKVSSLFVRSFHRSPLPVPLCSSFSPELSCLGGERLSAPVSQIARATSRNGCRTLFSRKKRNNYLALLPPLFALEHPFTDKGQSCFGRQSLFFLSCFLFFLSFLILGFSCFLFSFFVFILSFSYLFFFLFSSCFVFIPSFFFLLVLFSFLLSFFFLFYHSFFFPSSFFILSLFFLLFFILFFFQHLKLKVSLTSLFFININLVFSFILSFLVGNISVRYRDTLFFFFFFFFFFFFFFFRIPDSIFLFSFFTISRFSFFFPISDHSTFISILFHHFLFFFFVLFTCSRLIFDGFPSGVLMTASETLVPNRKPVVWTSRPLEILKIAKKSKVVRRKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C116</accession>
    <name>A0A812C116_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">3-beta hydroxysteroid dehydrogenase/isomerase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SPHA_27848</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Farmed</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the 3-beta-HSD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001091">
        <property type="protein sequence ID" value="CAE1252139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C116"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000495">
        <property type="entry name" value="3 hydroxysteroid dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002225">
        <property type="entry name" value="3Beta_OHSteriod_DH/Estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050177">
        <property type="entry name" value="Lipid_A_modif_metabolic_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245">
        <property type="entry name" value="BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245:SF51">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01073">
        <property type="entry name" value="3Beta_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="3-beta hydroxysteroid dehydrogenase/isomerase" evidence="4">
        <location>
            <begin position="41"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAE1252139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="330" mass="37104" checksum="D47E85281A0BE48B" modified="2021-09-29" version="1">MIWRQLTKRFLLIPSKCHYSISLYFTQTSKLPTMCKDEVIVVTGGSGFLGQHIVHLLQTQENSIKEIRIFDVKPYKKFLDHDDVKPVREIIGDICDPYEMKNALRGADAVIHIAGLVSFSTFPQFDEMNRINISGTKNVVTTCIEENVQRLIFCSTVDVVIGFDDIVNGTEETTTTPSKFLFPGYPESKHKAEQLVIRSNGTYLTNGQKLHTISLRPNVMYGEGDPFMITAALKSAKETFGWVIRVGDGSALFQKTYAGNVAWAFLKANEALRLNPDSVGGHFFFIPDETPIQNIFDSLHPYLTPAFSVFISFSAFLLFVALRDCPHEDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C217</accession>
    <name>A0A812C217_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DAAM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_28173</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001111">
        <property type="protein sequence ID" value="CAE1252903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C217"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="302"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="335"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="378"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="407"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="435"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="758"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="782"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="821"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="919"/>
            <end position="938"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1252903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="956" mass="111272" checksum="D4A14BCA427B31D0" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C467</accession>
    <name>A0A812C467_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SPHA_26811</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001025">
        <property type="protein sequence ID" value="CAE1249806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C467"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAE1249806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="177" mass="20838" checksum="51DCF255D3D40EFE" modified="2021-09-29" version="1">MKYLGISKYLILLSFSDFVICASGTTIMWTDVVFGINVRSFDKYFCKISVYVNRIFMVYSSWILLVISVDRLDHVFFPLKITRSKRLSLKLGIPFFVIAIWQSYTLYFYELNINSSIYLSIYLSIYLSILLNYSIYLSIYLSIYLSMNLSNLSIYEPFKSIYLSIYLSIYLSIYLSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C6Q6</accession>
    <name>A0A812C6Q6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_32230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001335">
        <property type="protein sequence ID" value="CAE1260431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C6Q6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1260431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="236" mass="27379" checksum="2C2A80D61352DB32" modified="2021-09-29" version="1">MRFSLSLSLSLSLSAILYAFSQFLIALPLLYSQIPSYSFSLYFSSNNTSVFLHHYIFLSIHYHCSLFLSSTVFSLFRFPLSINKSLTILTSISLLHFLLTIHKSLSLLSISHFHCHFSIRIHSLLHFIPLTIHKSLSLLSISLPLSFSIRIINYGFSLFNTCISINISTLHFYFLFTIHKNYHSIFINYGFSLFFTLNYTYYLLFINHYHCSNSFPVTSLFIHGFLYLTLAFSFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C8E5</accession>
    <name>A0A812C8E5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_31987</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001326">
        <property type="protein sequence ID" value="CAE1260036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C8E5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1260036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="260" mass="31682" checksum="B3B40F6CA4225361" modified="2021-09-29" version="1">MQTSAHRNSFLSNRFRSFFLFFLSFFDILYSFFLSFNFISLKFTFLSFFLSFFDIPYSFLLPSFLFHFSEVYFSFFLSFFLSLIFHIHSCCLLFYFISLKFTFLSFFLFYSLIFYIHFCSLLFFILFISLKFTFLSFFLCLISHIHSFYLSSFLVSFSLVFCIFRIHYCFLIFLSFFKTFSHNSFSFVSFFIVLFFIFKILLSYFFSIFHRFFFISFIPLNLQFFLSFFLSFFLSFFLFFCPPTNVIGVGGFLFLLFLHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C9J6</accession>
    <name>A0A812C9J6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_29391</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001169">
        <property type="protein sequence ID" value="CAE1255186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C9J6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="290"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="387"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1255186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="418" mass="49866" checksum="8F802C03525A54E1" modified="2021-09-29" version="1">MGHRKSTKQSAPNRPAHNQFLIGCQLLARLCDCFSYRMSHYSSPPYSSVLDQRVAVLENSEFFLHNVNHFKDDVDYSHIPSPSLLLSIRTTTSYSLIFNISFFPSSSIYYSTFYSLFLSPFPFLFFLLQYFIVFLFPNYLSLFLEYYSIPFSIFQFVSFFLSSSKKVIYAIPFNIFFSFFIYFSLFFFLSFFKSLIIFLFPNYISIIIFLPFFLCLSFFLSFFLSFFLSFFLSFFLSFFNKSFILFLPLFSLFLFFYYLPFPCLHHFSFFLSFFLSFFLSFFLSTNHTFFSLFCISLLSISIYLNNPFLNHIPFFTYFEMVSFLTKFSFSFYYFLTNSIKTTYTLSLHIYLSIYLSIYLSIYLSIIYPGGCIWKQVTTHYLSIYLSIYLSIYLSNSILYLSIYLSIYLSIYLSIYLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C9V9</accession>
    <name>A0A812C9V9_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">NEDD8-activating enzyme E1 regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SPHA_30980</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Farmed</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1 5">Protein modification; protein neddylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001255">
        <property type="protein sequence ID" value="CAE1257914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C9V9"/>
    <dbReference type="OrthoDB" id="1708823at2759"/>
    <dbReference type="UniPathway" id="UPA00885"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019781">
        <property type="term" value="F:NEDD8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01493">
        <property type="entry name" value="APPBP1_RUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000187">
        <property type="entry name" value="NEDD8-activating enzyme E1 regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030667">
        <property type="entry name" value="APP-BP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF29">
        <property type="entry name" value="NEDD8-ACTIVATING ENZYME E1 REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039099">
        <property type="entry name" value="APP-BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="7">
        <location>
            <begin position="72"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="43"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="50"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR039099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAE1257914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="611" mass="69793" checksum="3DFEDA79F1AEAB33" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CAP5</accession>
    <name>A0A812CAP5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">VPS54</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SPHA_30822</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001246">
        <property type="protein sequence ID" value="CAE1257572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CAP5"/>
    <dbReference type="OrthoDB" id="10259024at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039745">
        <property type="entry name" value="Vps54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012501">
        <property type="entry name" value="Vps54_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12965">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12965:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07928">
        <property type="entry name" value="Vps54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="541"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 54 C-terminal" evidence="8">
        <location>
            <begin position="329"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAE1257572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="572" mass="65030" checksum="21479CABD412FB43" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CB27</accession>
    <name>A0A812CB27_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA pseudouridine(55) synthase</fullName>
            <ecNumber evidence="2">5.4.99.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">tRNA pseudouridine 55 synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">tRNA pseudouridylate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">tRNA-uridine isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SPHA_30214</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Farmed</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase Pus10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.25" evidence="2"/>
    <dbReference type="EMBL" id="CAHIKZ030001213">
        <property type="protein sequence ID" value="CAE1256463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CB27"/>
    <dbReference type="OrthoDB" id="271937at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160148">
        <property type="term" value="F:tRNA pseudouridine(55) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2510:FF:000001">
        <property type="entry name" value="tRNA pseudouridine synthase Pus10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3190:FF:000001">
        <property type="entry name" value="tRNA pseudouridine synthase Pus10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039894">
        <property type="entry name" value="Pus10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048741">
        <property type="entry name" value="Pus10-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048742">
        <property type="entry name" value="Pus10_N_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01213">
        <property type="entry name" value="pseudo_Pus10arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21568">
        <property type="entry name" value="TRNA PSEUDOURIDINE SYNTHASE PUS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21568:SF0">
        <property type="entry name" value="TRNA PSEUDOURIDINE SYNTHASE PUS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21238">
        <property type="entry name" value="Pus10_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21237">
        <property type="entry name" value="Pus10_N_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pus10 N-terminal eukaryotes" evidence="8">
        <location>
            <begin position="79"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Pus10-like C-terminal" evidence="9">
        <location>
            <begin position="262"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00075270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00079393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00083669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF21237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAE1256463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="502" mass="58018" checksum="C81CD4C621BE1705" modified="2021-09-29" version="1">MAALMFENEFFSKNEGTLQEATKTLVDIGCCTYCVLRFLGEKQLRFYRRNEKTQTEILIEQLYYGGKPVENISRTEKPCITCLGILQKYCTEAFSQKIIEKVKSSGYVFSTYFCSLMLPVSLIVRQHSVYLQLREKFSEMYHGISDDDIPAVKEVWKWHNGPILSEALGVAFNLKSPFEVHINFTYKHSDRECSFLTDFHPDIFRRRKTKKADWEMYSRANVAKAVCDTVDSIYKRVYNFPPALPSDLAECERISCQHDSVFIAGRYNKYSRLLSQTPWLIEGIKKHETSVQELICTPLMERFQPVECKFSASGREDVDVKMLGNGRPFVIELVNPKKSDFTAEDFLQMQKEINTSTKDIFIRDLQAVSRDEIANLKEGEIEKTKSYSATCWSENCLSQDELDTLSTSKDLVLLQKTPIRVLHRRPLASRQRIIHSISAKKIDDHHFRLQLSTQAGTYVKEFIHGDFGRTQPNLSIIMKTECDILELDVESVDVDWPKQLNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CFK9</accession>
    <name>A0A812CFK9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_33862</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001424">
        <property type="protein sequence ID" value="CAE1263668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CFK9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1263668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="288" mass="32446" checksum="2E846B135313EB8E" modified="2021-09-29" version="1">MLDAILTLVARRRINKQKPFFITKNKQKPFFITKNKQKPFFITKNKKKPFFIIKNKQISFFIIKNKRSVLSLSPSLSLSLSLSLSLSLSPVAGYYGEARMGVVLITDSLPLSRPSPTSKKSEINHCTFLKSCRRHNGILTWHTLGDSRANTLLAGGKKKRLFCLSEFLSLLLHLLLPTTFLRHSLSLSLSLSLPLSLSLTLSYLMTNGEILSHTLSHTNTLPAGGKNDYSVSLYFFLFLFFFSPHHLSLSLSLSLSLSLSYLLTNGEILTLSYMHIYVCMCAMTDKNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CFP6</accession>
    <name>A0A812CFP6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_33957</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001434">
        <property type="protein sequence ID" value="CAE1263998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CFP6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1263998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="392" mass="44276" checksum="9CC0BD1AFC965BDB" modified="2021-09-29" version="1">MTNGWDELCRLTSVSSLVCDSSTNSLRAFVFMDISPNWHGYMANRYPLLLRVVINYSSVSLLITPPCRYHYSTKPLLITPPCLYHYSSVPLSLLLRATIITPPCHYQLILHATIHYFSVPASITPPYRHSLLLRAANYCSSVPLLITLPCRYHYYTVPLCHYQLLLRATIHYLYVPLSLLIRAAIHYFSVPLSNTYRYPLLLRAAIHCSSVPLLITPPCRYPLLLYVIINYFSCCYPLHLNAAIHYSCVPLSITPACRYPLLLRAAIHCSSVPQLITHPCCYSLLLLADIYFSSVPLSISPLCHYQLILRATIHYLSVPRSIAPPCRDKLLLRSVIHYSAVPLSLLHCAAIYYSSVPLSITSPCHFPLLLRAAINYSSVPLSFIPPGDIEDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CLT5</accession>
    <name>A0A812CLT5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_37712</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001690">
        <property type="protein sequence ID" value="CAE1272514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CLT5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="156"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="336"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="381"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="409"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="436"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="477"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="528"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="651"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="698"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="739"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="785"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="831"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="867"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="903"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="930"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="955"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="980"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1013"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1104"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1162"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1198"/>
            <end position="1216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1272514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1222" mass="140254" checksum="5697FCDBAF92A795" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CR80</accession>
    <name>A0A812CR80_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_41862</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002024">
        <property type="protein sequence ID" value="CAE1279757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CR80"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1279757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="248" mass="29588" checksum="67A308BB47F6009A" modified="2021-09-29" version="1">MELAVFTFNFPLFFLSFVFLSFFYCCLSFYFLFSFFLSVFLFLSFFSFLFLSFFSFLFLSFLLPFFLPLFFLCSSYLLSIPPSLSFFLPSFYLTFLCFLLFLLLFFLDFLLASFLPPSFFFFSIFFPCSFLPPLLSSSLHFSFLSFFLSFFLSFFLSFLFSFFLPSFPLSSFFLSFFLSFFLFLSSFLPPFLHTDLASPLFLSFLPCFFPTFLPSFFYSEILSLRIYLFIPFFSLFLFTVAFFGHWCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CU62</accession>
    <name>A0A812CU62_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_40339</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001902">
        <property type="protein sequence ID" value="CAE1276810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CU62"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1276810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="224" mass="26469" checksum="2A7A4CA81C75925D" modified="2021-09-29" version="1">MGIIDRNSDFSSLRFSVFSASLNINNFLVSLSLLLFHSSIVSKTPLLILLFSVFLFFCLSFIFSFFSLSFLFLLFFGSFFLSFVYISFFSSFFLRILSFFSSIFLFFFFSSIYPSIFLFIFLSFRISFFFLSSFSSIFCPILFFFFLTFLPLEFIILFNLFVFFLSFFLSFFLSMIHFDFLILLQFFLSFSLLFSFLMSSSPPLSLFSNLCSNIPSFYFCHIFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CYA0</accession>
    <name>A0A812CYA0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_46888</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002509">
        <property type="protein sequence ID" value="CAE1288033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CYA0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1288033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="273" mass="30908" checksum="712A4B3691D215C1" modified="2021-09-29" version="1">MTALSPSLLHSSSLFFTLFLSLFYTLPLSHSFTLFLSLTLLHSSSPSLFYTLPLPHSFTLFLSLTLLHSSSPSLFYTLPLPHSFTLFLSLTLLHSSSQSSFYFLSLSFSLSHSLNALLFFSLINLSLSLSPRPAPYISPLLKLYFSCKYYVPYYSRSKPPCLLSYNTLSHGAIMFLSSLLLSFPPSFSLSIFVFHSSPPSLFLTLFLFFTLSHSYTFIYHFCLLFINISSFCLLFINISSFCLLFINISSFCLLFINISSFFVVPLLLKTSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D194</accession>
    <name>A0A812D194_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_45290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002334">
        <property type="protein sequence ID" value="CAE1285229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D194"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1285229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="202" mass="22632" checksum="2808613444BA6E14" modified="2021-09-29" version="1">MYSLRFRRELEDLELGFLPAATLKSSPPGPPEMDRSPSSFIVKPLQIQITCATFSSQEMQTDRMSFRNFSSGARLFLFSKFPREVKGELIQLSGDTKKAIKRLPIKGDNSSDTAHNPERSSFRDAESRLRSNPTWKDSSFRVDSASRTYSGSSTNLPPVLCVSFGRNCESVSVMCLLDTGSWRTYLSSEIFEAPQQPGILRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D2P3</accession>
    <name>A0A812D2P3_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein mS33</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SPHA_45522</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002346">
        <property type="protein sequence ID" value="CAE1285598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D2P3"/>
    <dbReference type="OrthoDB" id="5980584at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013219">
        <property type="entry name" value="Ribosomal_mS33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13362">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13362:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08293">
        <property type="entry name" value="MRP-S33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAE1285598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="195" mass="23342" checksum="52C702A278F2B3B6" modified="2021-09-29" version="1">MGYCWPRTLHVHDTGLLQRRIWLCSNDDLPSHNVTEKDLDTFCKEHNFTAWANTSVKNNWLIKESMSYLLREMMNKYKEVNKENSQKTELTSSELYFCQLIVLKKKVPWLPSMLKGCLVWPIVYLDNERPYNMDPHVVEYYPPIREINSLMLRLRAHGLFRDEHLDFKEEMKRLRILRGKVKPKKGEGKRAMKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D3U3</accession>
    <name>A0A812D3U3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_45554</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002351">
        <property type="protein sequence ID" value="CAE1285682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D3U3"/>
    <dbReference type="OrthoDB" id="6142108at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1285682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="227" mass="25296" checksum="B3FFD79B1AF17D3A" modified="2021-09-29" version="1">MASERMDKEDEEERYYGLDGGYLFHNKEQITSLSNNSNLIFPACPRHVPGLSPAWSRLVPGLSPAWSRLVPCLVPACRRLVPCLVPACPRLGPGLSPAWSRLVPTSPQACLLGPGLSPYIGPGLSLLGPVCLSLYLSVHYLFIYLSIYLSTSTNILPRSYLSIYLSIYLSIYLSIYLSLFTSIYLSIYLSIDLSIYLSISICLSISIYLSIYLSIYLSIYLSIYLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D508</accession>
    <name>A0A812D508_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_50046</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002922">
        <property type="protein sequence ID" value="CAE1293864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="327"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="440"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="464"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="490"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="514"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="544"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="577"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="602"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="636"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="667"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="693"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="742"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="768"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="794"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="820"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="848"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="875"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="903"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="928"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="982"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1027"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1061"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1103"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1129"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1154"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1204"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1238"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1264"/>
            <end position="1283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1332"/>
            <end position="1357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1369"/>
            <end position="1393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1293864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1395" mass="166773" checksum="13458E66275D644C" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D5S9</accession>
    <name>A0A812D5S9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_47548</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002579">
        <property type="protein sequence ID" value="CAE1289214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D5S9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1289214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="169" mass="20374" checksum="536D2B2F76B4DF8D" modified="2021-09-29" version="1">MIYIKNIVTFGYEDRKRFLSFYQPYIYLSIYLSIYLSIYLSIYLSIYLSIYIYIYMFYSYLPVYIYLSIYLSIYLSQSVQYPSLSHYLSIYLSIYLSIYLSIYLSYTVYLSIYLSIYLSQSVQSLSLYLSIYLSIYLSNTAFLSIYLSIFINFLPYGCVNFYDILSFKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D658</accession>
    <name>A0A812D658_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_49376</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002817">
        <property type="protein sequence ID" value="CAE1292633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D658"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1292633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="203" mass="23611" checksum="1130151C7BF8D8EC" modified="2021-09-29" version="1">MLAKSETYLSIYLSIYLSISLFIIYLSMYLSNSFCPYLSISFFSHLSIYLSIYLSIYLSITDIHFLFMFIYLSIYLSIYLSIYLSQTFIFCTCLSIYLSIYLSIYLSIYLSIYNRHSFVSLPLSLSLPSERNVSSVCTCLYLSIFYLSIYLSIYLSITDIHLSLSLSLSRTPDRDISQSVHVYLSIYLSIYLSIYLSIYLSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DCX0</accession>
    <name>A0A812DCX0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_50532</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002988">
        <property type="protein sequence ID" value="CAE1294703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DCX0"/>
    <dbReference type="OrthoDB" id="6161281at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1294703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="457" mass="53328" checksum="568F00598423E7B7" modified="2021-09-29" version="1">MGLSGVAHLAPLIRLKFALSLCLSVCLSVSLSLSLSLSFNIYHFLLSFNIYLSIYLSIYLSIYLSIYLFPSVYLSIYLSISFCFCLSIYLSIAVCFYLLSLFLSVYLLAVSIYLSIYLSIYLSISICFYLSIYLSLFLSFYLCVFLSFYLSIYLSKPVSFYLSLPDSISLSLSLSLSLSLSIYLSIYLSICLSVSIYLSIINLQFYKWQYMLIYSSDSISQIFVPIPPRFVPIQTRFVPIQTRSIPIQIRFVSIQIRFVSIPPRFVPIQIRFVPIQTRFVSIQIRFVSIQIRFVLIQTCFVPIPPRFVPIQTRFVPIQTRFVPIQTRFVPIQTRFVPIQTRFVPIQTCFVPIPPRFVPIQIRFVSIQTRFVPIQTRFVPIQTRFVSIQTRFVTIPPLFVSIQTRFVSIQTRFYRFFLSIYLSIYLSIYLSIYLSQSVHIDVSISVHIYQFFYRFISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DE78</accession>
    <name>A0A812DE78_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_51809</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003164">
        <property type="protein sequence ID" value="CAE1297050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DE78"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="322"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="385"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="423"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1297050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="481" mass="57660" checksum="E7221CEDE9DFCCCE" modified="2021-09-29" version="1">MFCFIGVFHMIMVAVIFLVHEYFFTGPSSFVVSFSRLLFWHLPFLAFFLCCFFFSTSFLASSFFSLLPLFILPLLFLFSTSFLASSFFSLLPLFLLPLLFLFLDFFFLHLPFLAFFLCCFFFSTSFFWHLPFLAFFHCSFFLCCFFFSTSFFHLPFLAFFLCCFFFSTSFFHLPFLAFFLCCFFFSTSFFSSSFFSLLPLLFLFLTFFFCQFPFFSLLHLCFSSLLFCHLPFSAFFIYCFFFSTSFLASSFFSLHYCFFFFHFSAFFIYSFFFSSFFLLLALLPSLFYRLSFNDVSISTIFHFSLLHFYRILFYLHTSFYSFFLLSRLLSCLSFLVFFFVVFICYCLLSCRPPLPHILHLLFYRHPFFFSFFYVILLFYQPFNFVVFLFTLVFFFSTFFILFFTLISFYFLPPPFLIIYLFPLFYQLSFASFSFCLSSFFFAFFFFPFSFETSIYLSISPHLSPLSLSLSLSLSLSLSLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DG11</accession>
    <name>A0A812DG11_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_54639</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003567">
        <property type="protein sequence ID" value="CAE1301808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DG11"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1301808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="158" mass="19643" checksum="15BE63EE7274B12E" modified="2021-09-29" version="1">MIEILDQTRWNLLFSLYIHSFTFCLFFSFFLSFFCLSFFCLSFFFSLSFSSLFSLFFFLFFCLFLSFFSLFFLFFSFFFLFFSVFLFSLFLSFVFSLFLSFLFFLSLFFLFSLFLFSSLFLSFFLFSFFFLFSFFPLIFLSFFFLFSFNCCHFFFHFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DGU7</accession>
    <name>A0A812DGU7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_52671</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003308">
        <property type="protein sequence ID" value="CAE1298612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DGU7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1298612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="220" mass="25719" checksum="2E7870100C8BC95B" modified="2021-09-29" version="1">MAAPSGKTTPVRISNGCRPCCEGRRLFSPVQYKPFLCVLQVTRKTRRIADLLVDVGICVLEMLFFLSFFIYLSIYLSIYLSIYLYIYIYIYIYTNFTYSFFLIVSFFSSFFIPSFLHLFFLSFFLSNCFLPFFLLHPCLLSFFLSFSSLPSFTSSFFLSFFLSNCFLPFFLFHPCLLSFFLSFFLSFFLSYSCLPSPLLSLEDKCREDGLKVLLDLLAKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DHU4</accession>
    <name>A0A812DHU4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_54444</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003537">
        <property type="protein sequence ID" value="CAE1301477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DHU4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="335"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="369"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="413"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="448"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="496"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="528"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="553"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="578"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1301477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="619" mass="70755" checksum="98259A7F58095893" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DJI6</accession>
    <name>A0A812DJI6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HNRNPA1_3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SPHA_53427</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003402">
        <property type="protein sequence ID" value="CAE1299814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DJI6"/>
    <dbReference type="OrthoDB" id="1875751at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000040">
        <property type="entry name" value="Heterogeneous nuclear ribonucleoprotein A2/B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48032:SF6">
        <property type="entry name" value="RNA-BINDING (RRM_RBD_RNP MOTIFS) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48032">
        <property type="entry name" value="RNA-BINDING PROTEIN MUSASHI HOMOLOG RBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="12"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="101"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAE1299814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="282" mass="30921" checksum="13779F4B730E8270" modified="2021-09-29" version="1">MSVTTGDDEKFSKLFVARLSTDTTEESLKLYFEQFGEVAKCVIVKNPSTNQSKGFAFVTFAKPESLNQAQKARPHTIDNRTVDCKRAIPQDEAPENKITVNKMFVGGMSEDTTEEQIVEKFSPYGNIEKIDLIKDKSTGKYKRFCFVTFNDHDSVDQCVIHKHFNLAGKKVEVKKAVSKDELLAAANRGITPYAPQGTRMPTPTSYGRGVYSGSSYGYGDGSSGWYQGFGPGGNNRIYSDDGFGNSFNSPYGEAYGGGPTRGRGIYTPRGAGPYGGTYGSQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DKI9</accession>
    <name>A0A812DKI9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_58072</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003948">
        <property type="protein sequence ID" value="CAE1305669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DKI9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="323"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="379"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="421"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="445"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="478"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="514"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1305669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="544" mass="64482" checksum="78B12E4EE82369A0" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DMW0</accession>
    <name>A0A812DMW0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
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            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003651">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </evidence>
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</entry>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
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                <person name="Bekaert M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">Farmed</strain>
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    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
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    </evidence>
    <sequence length="344" mass="40486" checksum="A1C471B2BC7FF992" modified="2021-09-29" version="1">MPYYLSIYLSIYLSIYLSIYLSILVCSYLSIYLSIYLVLYLPPIYLSIYLSIYLSMSMVCSYLSIYLSIYLSLSLSLSLYIYIYIYIYIYIERREKKGERENISLFLYTELAIYLPPIYLSIYLSIYLSIYLSIYLSIFIFPTLTMTLNCSCLLCVEKTLLEREIMLPIFKDTSSIYLSIYLSAHSNHLSIYLYSSFSYLSIYLSIYLSIYLSIYLSSIYLSIYLSIYLSIYLSIFVLFISIYLSIYLSIYLSIYLSICIVIPYLSIYLRPFHIYLSIYLSIYLSIFLARSLYPILSYLSIYLSIYSVSLSMYVSIYLVCSYLSIYLSIYLSIYLSIAICSKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DSC9</accession>
    <name>A0A812DSC9_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein 98</fullName>
        </recommendedName>
    </protein>
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        <name evidence="13" type="ORF">SPHA_57723</name>
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    <organism evidence="13 14">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Extracellular exosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TMEM98 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003900">
        <property type="protein sequence ID" value="CAE1305232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DSC9"/>
    <dbReference type="OrthoDB" id="5978425at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1410.10:FF:000003">
        <property type="entry name" value="Transmembrane protein 98"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1410.10">
        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029668">
        <property type="entry name" value="TMEM98"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32510">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 98"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32510:SF3">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 98"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="8 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032495947" description="Transmembrane protein 98" evidence="12">
        <location>
            <begin position="25"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAE1305232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="245" mass="27633" checksum="176E29A95B4EA051" modified="2021-09-29" version="1">MRKSIDKCCSIINLLSFLQCNTVALVLVCRNCYCRQMDLITMQHKDNSPDTQLIHSMETVPPAPDPNTVEMDDIEFTSPKLEEILQDENYIEDATGLVPHCLAILKICHELTNKLVAMAMGSSQQIHMQESMTDLIAMAKRITPRVDEVVRSMYPPLDPRLLEARCTALVLSVNHLVYVVKNAYRLAGTLDWADQSLADVEDHLRVLKEASIAYDINCRILPNNSTTMDNQQQATVTIRDESSQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DSV2</accession>
    <name>A0A812DSV2_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2 5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SPHA_57938</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Farmed</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2 5"/>
    <dbReference type="EMBL" id="CAHIKZ030003931">
        <property type="protein sequence ID" value="CAE1305528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DSV2"/>
    <dbReference type="OrthoDB" id="433738at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000025">
        <property type="entry name" value="Peptidylprolyl isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050689">
        <property type="entry name" value="FKBP-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10516:SF443">
        <property type="entry name" value="FK506-BINDING PROTEIN 59-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10516">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0697">Rotamase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="379"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="425"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type" evidence="7">
        <location>
            <begin position="36"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAE1305528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="451" mass="50521" checksum="866CFDE78924A9E5" modified="2021-09-29" version="1">MTQEEVTGIDVTPEKNGGVMKEILREGSGDEFPQTGDKVYVHYVGTLTDGSVFDSSRERDEKFSFSLGKGSVIKAWDLGVATMKKGELARLTCKPEYAYGKNGSPPKIGPDATLIFEVELFEWKREDISPNKDEGILRRIVKSGEGRKTPNEGATVNVHYIGYHENQKFEERDVTFVVGEVHILLSFIRLDQRQRCCQVHLRLCSSASNSATYIVGIRFLSQPSSVLFFDTLYLQYNSHCYATCITPNYAPSSTFCCMQLSTIQPRGSDPPACMSKTILVYSFYPSQVESPYPFRTPNLQFLYPSATSQSAAPPSSPCMQPLSLSLSPPPLAAFLSVPPLRLFTNQGVTSRSASSILWCSCFPSHYNCRTTASPCPSKGLIVIGYIHYFFLSLSLYLYFSLSLSLSDEMPKYLVVSIYRGDKEKFLFLSFLFLFFPTRSLASICLQRKKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DSW8</accession>
    <name>A0A812DSW8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LHFPL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SPHA_60773</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004241">
        <property type="protein sequence ID" value="CAE1308975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DSW8"/>
    <dbReference type="OrthoDB" id="5873721at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007605">
        <property type="term" value="P:sensory perception of sound"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019372">
        <property type="entry name" value="LHFPL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12489">
        <property type="entry name" value="LIPOMA HMGIC FUSION PARTNER-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12489:SF1">
        <property type="entry name" value="LP10272P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10242">
        <property type="entry name" value="L_HMGIC_fpl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="17"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAE1308975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="163" mass="18067" checksum="52727975D6083CBA" modified="2021-09-29" version="1">MLICVAALLLFFCFKKVFIFVLCGILEIISAILMFLGCVIYPSGWDDDNVQALCGKDAGEFKLGDCGMRWAYILAILGIVDAALLAILAFILASKRTKPTNSYYTGKITKAELYPNYMTDTIRSHGTIIRPTMMTVPDSNECYSEYSQQSGNRKSLISSGFQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DTG6</accession>
    <name>A0A812DTG6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_58847</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004049">
        <property type="protein sequence ID" value="CAE1306610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DTG6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1306610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="298" mass="35533" checksum="E4FF284FBB84FAA3" modified="2021-09-29" version="1">MAHHNFLTLSSPSSSISFFLSFFLSCSCFFFLLSFTCLYFLLYNTFLRSFLSFFLFASFIPCCSFLLLLWNLCRRSSFSFVCSFSFILFSVTFSFAVILFFVLSFFLSFFLSPTFLSSLSYFSFCLSFFTFYFFSVIHFLSFFLSFFLSFPLPFSLLYFSLFSFFLSFFLSPTFLSSLSYFSFCLPFFTFYFFSVILSFFLSFFLSFFLSFPLPFSLLYFSLFFFSFFLSFFRHLFFLRCHTFLSVFLSFSLSLYLSLCYIFPYSFSFFLSFFLSFFLSFFLSSTFLSSLSYFSFCLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DTS0</accession>
    <name>A0A812DTS0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_60207</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004175">
        <property type="protein sequence ID" value="CAE1308321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DTS0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="647"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="757"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="287"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="313"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="458"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="802"/>
            <end position="812"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1308321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="833" mass="89665" checksum="94925BD157853EDE" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DU58</accession>
    <name>A0A812DU58_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_60385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004198">
        <property type="protein sequence ID" value="CAE1308521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DU58"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1308521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="309" mass="36573" checksum="6956CDDEDC26CD33" modified="2021-09-29" version="1">MPASFAVFPSASEYDTSTLLNKRLSFFSFVSARVFFLSLFLSPFESFFLPSFIPSFLSLLLSFFVGSFFTSSNLSPLLSFFFCSNRSFFSSFLLPIFLPFFLSFFFLSFFLCSNLCSLLPFFLSFFLSFFLSLFQSFIPSSLLSFFLSFFFVLIFLPFFLTFFLSFFVPIFLPFFPSFFLSFFLSFFLSFFQSFFPSSFFLYSNRSFFFSFFLLIFLLFFLSFFLSFFLSFFAPIFLHFFLSFFQSFFLSFFLSFFLSFFLSFLVSSHLFNVCVFVCLSIYLSIYLSIYLSVRLYINLNVSIYLSIYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DUP0</accession>
    <name>A0A812DUP0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_59381</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004111">
        <property type="protein sequence ID" value="CAE1307346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DUP0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1307346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="268" mass="31294" checksum="079C12DA5BB38FE8" modified="2021-09-29" version="1">MASVEIANYLLLSVTLQYLACYFFSRQSLVRRMRRSICQEINAFPSISIYLSIYLSIYLHIYLGLSISIYLSIYLSMYLNLFIYLSISLSQFIYLSQFIYLAINLSISIYLSIYLSIYLSSSLYIYLSIYLSIYLNLFIYLSICLSQFIYLSIYLSNGVHIYLAIYLVSSYLSIYLSIYLNLVIYLSISLSIYLSMSIYLAINLSISIHVQLSLFRATHLNTYEYLSTYLHLYPAVSLSIYPSIYMSQFISIYLSIYLSIYLSIYLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DUV4</accession>
    <name>A0A812DUV4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_59613</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004123">
        <property type="protein sequence ID" value="CAE1307479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DUV4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1307479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="222" mass="24372" checksum="6EC270B1B8609292" modified="2021-09-29" version="1">MREADLLTQIIAFSLFRFLPLAQSEPRRLPPLSLSLSLSFSFSVFSVSLTLSLSLSLHTLSLSSPLSFFFFLCLNLSVCVSFCFFFRLNLCLFDCLSLSLSLSLTPHLSFFFFHCLNLNLSDCASLSLSLSITPSLCFLSFSSSVSIRNSLTVCLAHSLLLSFSCYIKISVPLFVSLPLSVSSSNSVSYSLSLSPPPLSLIFSHTLNIDLSLSVSLPRSQSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DVP4</accession>
    <name>A0A812DVP4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_61689</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004384">
        <property type="protein sequence ID" value="CAE1310051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DVP4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1310051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="278" mass="31412" checksum="D7BB89FBDB7059A5" modified="2021-09-29" version="1">MGSSTIFVVDRSIPSPGSSTKGVLIYSLPTEVSPHRLHQPRDMGLIYSLPTEVSPHRVHQPRDMGLIYSLPTEFRVATKRWNIYSLPTEVSLTGFTTKYGLINQPRDMGLIYSTKRYVVADRSNFTDQPRDVGLSIPHPRFADKYPLTGFINQEIWATVGSSTKRYGLNIFVADRSIPTGFTQGSYIQEVSLTDQPRDMGLIYSLPTEVSPHRVHQPRDMGLIYSLPTEVSPHRVHQPRDMGLNIFVADRSIPSPGSSTKRWAGLNILRCRFVNQRWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E082</accession>
    <name>A0A812E082_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">UPF3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SPHA_62339</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RENT3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004450">
        <property type="protein sequence ID" value="CAE1310811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E082"/>
    <dbReference type="OrthoDB" id="18087at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12455">
        <property type="entry name" value="RRM_like_Smg4_UPF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000717">
        <property type="entry name" value="regulator of nonsense transcripts 3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039722">
        <property type="entry name" value="Upf3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005120">
        <property type="entry name" value="UPF3_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13112:SF0">
        <property type="entry name" value="FI21285P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13112">
        <property type="entry name" value="UPF3 REGULATOR OF NONSENSE TRANSCRIPTS-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03467">
        <property type="entry name" value="Smg4_UPF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UPF3" evidence="6">
        <location>
            <begin position="12"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="165"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="527"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="177"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="267"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="415"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="544"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAE1310811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="567" mass="67623" checksum="F5AFBFD607D50555" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E0Z5</accession>
    <name>A0A812E0Z5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_63547</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004553">
        <property type="protein sequence ID" value="CAE1312289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E0Z5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1312289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="317" mass="38095" checksum="1660065A10EE65EB" modified="2021-09-29" version="1">MSYLSFLIFHQKKNKLFLSFFLSFLLFSLLLSLLLSFFLSFFLFFFLSYSFVYLFTRFPSYLLVLMFLSSYASLQLKRSSVFLYTCCNCSFYFCSINLLFFLFSLLLYCFTSFFFYFFIFLHCFIQYLFLSFSFFRFNHCFIQHIFLLFYFFLFNNYFIHQLFLPSFLPSFLPSFLPSFLPSFLSFFLPSFLSFFRSQSFYHFFISFLFVYRFLFLFSPHYSFYFSPTFPLSFLFHIVLNHVCPSIPFFIHKLAFLAFSSFPAISFFLSFFLSFFLLPLNSRSTHPPFSMISSRCSALSTNQTVTFMTNCKQGAPVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E329</accession>
    <name>A0A812E329_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_66316</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004782">
        <property type="protein sequence ID" value="CAE1315378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E329"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="302"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="330"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1315378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="369" mass="46159" checksum="F987311B21827373" modified="2021-09-29" version="1">MLLFLLILLRFTFSFFVFLSLVFLFFFLFLSFFLSFLFFLSFFPFFLSFLFIFLFFLSLSFFNFTTIYIFLSFLFFLFLSFFFFFFLSFLSFSFFLSFFLSFFSFFSFFFFFFSCYSFFLILLRFTFSFFVFLFSCLSFSFSFFLSFFLSFFLFSFISFFFLLHATLSFNFCTIYIFFLFLSFSYLFFSFFLSFFLFFFLSFFLIFMLLFLLILLRFTFSFFCLSFFLVFLSLFFSFFLSFFLSFFLFFLFFLLSFFLSFIFHAFFFLFYFTTIFFFFLCLSFSCFLSFFFFFSFFSFFLSFFLSSFLSFFLLFFMLLFLLILLRFTFSFFVFLSLVFLSLFLSFFLSFFLPLFLYFFLFFYFSCYSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E615</accession>
    <name>A0A812E615_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_67768</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004908">
        <property type="protein sequence ID" value="CAE1317147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E615"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="118"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="176"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1317147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="302" mass="35432" checksum="723CD32F688DB503" modified="2021-09-29" version="1">MGSVPTTGHDSDSEESERLVNLRSTPLEEPDNSLDNESFEDSPTIGSQNTNAVRLDSSTGGSSSEDEARVVLLWKSTKQKRPAPDSDFFSFFFLSLSFFFFLNFFLSSNLTYIFLSSLLFQSFFFSFFLSFFLSFFLSFSFFLSSNLTDFFSFFFSLSLSFFFFFLNFFLSSNLTYIFSFFLTLSILLFFSFFLSFFLSFFLSSNLSLTSFLFFFLSLSLFLSFFLNFFLSSNLTYIFLSSLLFQSFFFFLSFFLSFFLSFFLSTYHSFIRSFIPSILPFLLFSFFLSFFLSFFLSFFLSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E9P5</accession>
    <name>A0A812E9P5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_68656</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005007">
        <property type="protein sequence ID" value="CAE1318157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E9P5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1318157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="173" mass="19705" checksum="A4995231B126DE00" modified="2021-09-29" version="1">MRGWVFVQIFFFTNTFSFFLSFFLSFFLSFFYILILSLSLDLFPLSFSFFLSLYFSLSSFGAANLFIHLSHLFSHSFSLSLSSLPPPFICLSPSFAFPLNTPPLSLSLSFFLSLSLSLPLSFLSLIFFCFLLFITNSSPLSLSPSLCIIYFPSFSFSFCKTIPSFRTLIITSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EAJ0</accession>
    <name>A0A812EAJ0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_69643</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005098">
        <property type="protein sequence ID" value="CAE1319176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EAJ0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1319176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="267" mass="31462" checksum="F8BF8001EFD29EFF" modified="2021-09-29" version="1">MLIQTIFHTTYFNTIYLPYNLTSIQSIFHTIYLNIIYLPYNLSSIQSIFHKTCLPYNLSSIQSMLIQSIFHTTYFNTIHLPYNLTSIQSILHKIYLNTIYLPYNLFQYNLSSIKPILHTIYITYSLSSIHTILHTRYLPYNLTSIQSMLILSIFHTICLPYNLSSIQSVFHTICLPYTCFHTIYLPYNLYRAVTETNKLLHKPCPLIYPSPCYNFGTLICLSIYLSIYLSIYLSIYLSITPIFLSIYHCNITYYLSIYLSIYLSIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EB43</accession>
    <name>A0A812EB43_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_69433</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005077">
        <property type="protein sequence ID" value="CAE1319002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EB43"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021741">
        <property type="entry name" value="DUF3311"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40034">
        <property type="entry name" value="BSL5891 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40034:SF1">
        <property type="entry name" value="BSL5891 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1319002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1197" mass="142780" checksum="84427B73B69F3FD5" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EC05</accession>
    <name>A0A812EC05_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_72337</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005310">
        <property type="protein sequence ID" value="CAE1322343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EC05"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1322343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="232" mass="27622" checksum="91B10E0C2F0EDB80" modified="2021-09-29" version="1">MHIYLNHFISIYLSIYLSIYLSIYLSICYGHYPGHFLSIYLSIYLSIYLSIYLSIYLSRSFQIYLSHFISIYLSIYLSIYLSISNFFLSSFLFYFSFNDFSFSFFTFQTLFVGLLFFITFPRFFILFKNVFSVSILSSHKFFFCPLTSILHSLSETYTVQTVDNESSSHFQSIEVGLSTPRRTEIIKIETERNQISKFLRRIDENSFIGRERKIRIFFQAKANKILWLFLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EEC2</accession>
    <name>A0A812EEC2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_69354</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005072">
        <property type="protein sequence ID" value="CAE1318932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EEC2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1318932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="218" mass="25766" checksum="E94FA0F099F47F08" modified="2021-09-29" version="1">MYVSIYLSIYLSMSIISYSPTFLYVSIYLSIYLSIYLSIYLNILIYFVSFQLFHIYLSIYLSIYLSIYLSYPRLFLSIYLSIYLSIYLSIYLSILGGSYVCMYVCMYVSIYLNILILFFLSTCSLSIYLSIYLSIYLSISLSIYLSIYLSIYLRMFISIYLSIYLSIYLSIRLDPGQRRLFSLSVPFRLPSLSLPSLSLSPFVYASFEYRYRVHYSIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EEC5</accession>
    <name>A0A812EEC5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_71034</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
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    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005469">
        <property type="protein sequence ID" value="CAE1326121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EHU9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="163"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1326121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="213" mass="24744" checksum="56B6B6C8B8B152F8" modified="2021-09-29" version="1">MESRIVAPTPRGEISSQSSGRSDSDTSLPPPQQQEITRSQRTINRAFLFCDKIISFINTALFFVIIISFFFFFVFHSDSFCLFHISLFFINIHSSSVNILFFSFSVFFFSLSFLNSFFFPSSFFFLMFLLPLFIIILPFVTIFRSSPSLSLFLSFLTIVSFSFPFHSCFSFVFLSCFLSSFIIIFYLPLILSSLIFLLVFSFSFYSIIFSFIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EJM7</accession>
    <name>A0A812EJM7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_76755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005496">
        <property type="protein sequence ID" value="CAE1327232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EJM7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1327232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="233" mass="27505" checksum="9A1820567BFACC2E" modified="2021-09-29" version="1">MVSDGTLLRSLESNLSIYLSIYLSIYLSQFLHIYLSTYLGQLSIYLSRSVHYLSIYLSIYLSIYLSQTVFPIYHGLPWTVFSIYLSIYLSIYLSIYLSSKDYCFSNLSIYLSIYLSIYHTFFPIYHRLFPIYLSIYLSIYLSMTSSHEPLLSETDSLTIYLSIYLSINLFISFYLSVYLSHLSFFLFSFFVWFYLSIYLSIYLSIYLSISFCSYLSIYLSIYLSHSVSIYLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EK80</accession>
    <name>A0A812EK80_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_74621</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005435">
        <property type="protein sequence ID" value="CAE1324947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EK80"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1324947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="174" mass="20419" checksum="31A7171D1C951675" modified="2021-09-29" version="1">MYLSIYLSIYLYISLFIYLAILTFSRYLSIYLSIYLSQFLHYLSIYLSQFLHYLSIYLSIYLSQFLHYLSIYLSISISFFPLLRLNLSIQTSLFIIFLSETCLHFQIHSFLLSSLYTRALLIRHLLLFGPFARTVHSNDIATCNFHSSSIVAGAYYVQQLTTFALISNSIFRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EN60</accession>
    <name>A0A812EN60_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_76730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005496">
        <property type="protein sequence ID" value="CAE1327241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EN60"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1327241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="223" mass="26416" checksum="A1C061A6CF7A60F0" modified="2021-09-29" version="1">MRQRRDNELILFISIYLPQSESIYLSIYLSIYLFVCLSSIHYLSIYLSIYLSIASLHIYLSIYLSHTDSIYLSIYLSIYLSSIHYLSIYLFFASLHIYLSIYLILILSIYLSIYLSIYLFVFYSFIYLSIYLSHLFISISLSIYLILILSIYLSIYLSIYQSIYSNDQDTIEFVHIYVSTYALSIYLSIYLSIYLILILSIYLSIYLSIYLLPRVILHPVSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EP98</accession>
    <name>A0A812EP98_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_79364</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005566">
        <property type="protein sequence ID" value="CAE1330069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EP98"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="317"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="344"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1330069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="375" mass="44527" checksum="5CC95EAA600D8CCD" modified="2021-09-29" version="1">MEFNVRKKIRLYRETYNFETLIFGFFFISFFLSFFLSIYLSIYLSQFVHIYLLFLFLSILYLSVFCSYLSIYLSIYLFAYIYVLAVEPGVARGYNIVVFFLSFFLSFFLEPVHFFLSFFLSFFLSFFFLFLYFIYLFINFLNLALSLSLSLSLSLSFFIESIRLFFCSFFLSFFLYSEHFPSFFFQADCFFLLFSMIFFHFLTSCLSYFVSIHSSTIYGLLSSFSDPNLFFFFFFSQFHPKVSLIFLDLPLTKLHVRLNLLSIYLSIYLSIYLSIYLLVFSLIYLSIYLSIYLSIYLSACLSACLSQSIHTYLSINLFIFWFISLSPSLCICLSIFLYEFLSFFFYYLSSFSLSLSLSLSLSSSISLSIYLSVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EQN5</accession>
    <name>A0A812EQN5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_75609</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005465">
        <property type="protein sequence ID" value="CAE1326042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EQN5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1326042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="260" mass="30017" checksum="BEF6D0866544DC42" modified="2021-09-29" version="1">MKFCPFPDEPHQTIATTSHGSTLCLPSGQVKSTHDEQCLSLKKSFCRIFQIPSTRSYSLLSRKSIHYLFIYLSQSVHIYLYIPVYSYLSIYLSIYLSIYLSIYLSIYPLSIYLSIYLSIYLSIYLSQPYLSIIYLSIYLSIYLSIYLSIHLCILIPQTVSIYLSIYLSQPSVSIYLSIYLSIYLSIYLSISALSIYLSIYLSLFISIHLSILIPQTVSIYLSIYLSIYLSIYLSIYLSIAAYCYLCVRAHVSVQNYIVIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EU62</accession>
    <name>A0A812EU62_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_80420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005599">
        <property type="protein sequence ID" value="CAE1331170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EU62"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="280"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1331170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="300" mass="35465" checksum="0AA2D3AEBE58FF67" modified="2021-09-29" version="1">MKLRKLPNIYLSIYLSAAYFSSLSLSIFLSHTVLISLSFYLMLLISISWFLSIYLSIYLSIYLSIYEYNDTIADYIDIFKITMIKCYNAVIYLSIYLSIYLVLIFTVKIYLSIYLSIYLSIYLSCSDIQTEGISLYLITFSSTVKLYLSIYLSIYLSIYLSIYLSIKIFHYLSIYLFHVQISRINTYLSSIYLSIYLSIYLTYSIYHIYLTYSNLQMFRSTSHHIYLSIYLSIYLSIYLSICLMFRSTESTHHLSIYLSIYLSLSIYLSIYLMFRSTESTHLSIYLSIYLSIYLSIYLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EUU5</accession>
    <name>A0A812EUU5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_79725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005575">
        <property type="protein sequence ID" value="CAE1330411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EUU5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="314"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="352"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1330411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="376" mass="45818" checksum="17FA845FFC112F3F" modified="2021-09-29" version="1">MFGLIYFSLLSFGLCELSFHLFTNTHTQSFSLFLSLYFISFFFIFFSFSFLSIIFLLFPSLLALFTFSFLRLYFLHPFFFPSFIFNFSFVIYFRFFFLYFRFFLSLFPFFLSFFLSFFLSFPSSLPSLFHSFIHLTFLSFYTIFLIPFYTLFIHFIHFLFFPSLTPSHVSFFFPPFFHSSFSFFLTLIHLYVLLYIAISFNLFLFVFQISFPLFNNCLPFLHLYNLFFYFFACLSFFFFHDIVSSISLTILPHLLIFPLFVFFFRFFFLFLAFVLLSHICSFFLFFLFLSFFLSFFLSFFLSFFLSFLHSGFCLLIYSFILSINCSLFFLAFDLSFFLFFIYSFFHSRVFSFFHSLIISFFMISPLQFYFLLFLIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EXK6</accession>
    <name>A0A812EXK6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_81249</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005628">
        <property type="protein sequence ID" value="CAE1332181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EXK6"/>
    <dbReference type="OrthoDB" id="9046871at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045860">
        <property type="entry name" value="Snake_toxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57302">
        <property type="entry name" value="Snake toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1332181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="299" mass="35297" checksum="DF0CC45AA81F78F7" modified="2021-09-29" version="1">MITLLSIYLSIYLSIYLSIYLRKKHILNQLIYNINAILSIDLSIYLSIYLSIYLSKIVKTFFVCSFFLSFFLSFFLSFFLSFVCSFFFLSFFFHSFFLSIFFFPSFFLTFVLYLVRSFFLSFFLLMSFLILKTFLFSEFLTFFLLLFPSFSSTLYIFTPLSVFLSFFLSFFLSFFLSSSSSSSNLCALKCYECDNELTNNFCMSDLNLHSCGQGLDTCQTIVAYSVNINFILSFYPTHYFQFFLSFFLSIYLSIYLSIYLSRHLSIYLSIYLSIYLSIYLSTGTHKQIYLSIYLSIYQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EZ22</accession>
    <name>A0A812EZ22_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_80361</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005598">
        <property type="protein sequence ID" value="CAE1331138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EZ22"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1331138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="191" mass="22103" checksum="812D479296442D43" modified="2021-09-29" version="1">MFGIPLCISFLPSLSLYLWDCFHDKFIFQTRHSAHMIPFPSSRFILRSQSAFYLSIYLSIYLSTYLSISICSYLSIYLSIYLSIYLSQSVHIYLSIYLSIYLLIISIYLSIYLSIYLSIYLSIYLSQCVNMYLSISVYSYLTLLLCIGSSQPSFLVPNPTFLPNANLSHLSDKCISHHSLSFVGQPFFLYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AKA7</accession>
    <name>A0A812AKA7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_601</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000013">
        <property type="protein sequence ID" value="CAE1140564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AKA7"/>
    <dbReference type="OrthoDB" id="10061555at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1140564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="251" mass="28514" checksum="C15E8E550F92C2DC" modified="2021-09-29" version="1">MSEPCLTQFTATRPERRPALIARGLSRLNVDIAALSETRFPGEGSLQEHGARYILFWSGKPAPERRLSGIGFMISTSIAARLENLPTGHSDRIMSMHLPLKNNQKNKDCFDENNQKIQKLLAKKRSAHHSHLGQPSCSVRRAAFCLICSKLREIQNEWWTIIGERNQLFTDLSDYIGFYEALTEVYGPSHRVQSPLRSADGRVLFTDKESILSRWSGYFQALFSADHVVQDPGVLRISTNKAKQNWINYPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AUK0</accession>
    <name>A0A812AUK0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_4452</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000141">
        <property type="protein sequence ID" value="CAE1155415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AUK0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="356"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1155415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="379" mass="46777" checksum="4115DFD21409E25C" modified="2021-09-29" version="1">MSSSFSRYVLSEVIRYRLLFSFLISPFFIYSFFFLSFICMSLPFFFKHHLFDLRLVFLFFFLTSSILFIQSRFDCIPFLSFIIFLLPITLFYFIYSFSSFLSLLNYFFLSFHSFLLILHLFFLFLSFFLSSVLSFVLLYLTTRFISFSFILNLLFILSFFLSFFLSFFLSKYTIFLLLNILFLFYLLQIFFSFFLSFFLSFFLSFFLSFFLSFQIQDFIFSFTLNILSFFLSFFLSFFPFFFQIYLFFIFLLRFFIILSFFLSFFLSFFLSKYRTLFFLLRLSFCLIYFFFSFSFIQFIHSFFHSFFFSFFLSFFLSFFPNTGLYFSFTLNILSFFLFLSFFLFKYRAFHLPNIFLFHLLQLFFFLSFFLSFFLSFFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AYF1</accession>
    <name>A0A812AYF1_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteasome activator PA28 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SPHA_9283</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Farmed</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PA28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000297">
        <property type="protein sequence ID" value="CAE1167200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AYF1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008537">
        <property type="term" value="C:proteasome activator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061133">
        <property type="term" value="F:endopeptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000045">
        <property type="term" value="P:regulation of G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061136">
        <property type="term" value="P:regulation of proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.180">
        <property type="entry name" value="Proteasome activator pa28, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003186">
        <property type="entry name" value="PA28_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036997">
        <property type="entry name" value="PA28_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009077">
        <property type="entry name" value="Proteasome_activ_PA28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036252">
        <property type="entry name" value="Proteasome_activ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10660:SF2">
        <property type="entry name" value="LD45860P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10660">
        <property type="entry name" value="PROTEASOME REGULATOR PA28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02252">
        <property type="entry name" value="PA28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47216">
        <property type="entry name" value="Proteasome activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="63"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="97"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="134"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="172"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Proteasome activator PA28 C-terminal" evidence="4">
        <location>
            <begin position="630"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAE1167200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="726" mass="83007" checksum="6DB785D583695FF3" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AYN9</accession>
    <name>A0A812AYN9_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_7188</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000232">
        <property type="protein sequence ID" value="CAE1162214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AYN9"/>
    <dbReference type="OrthoDB" id="2016582at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1162214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="289" mass="31757" checksum="6476A70209402F33" modified="2021-09-29" version="1">MLINSDNIISSATGIQQGEPLGPLLFAMAIDGVARSIASPSNIWYLDDATLGGSIEAVAADPRRVIPALSLLGLEINSSKSEIINLNYTADDFESAIRDIRLILEDIKITPKEELHILGSPVFPMAIRECLDTKRVILTRMTEKLQLIDAHLALFLLKNSFSLPSFLYTLQSAPCYLEQNFLNEIDITVKRCAELICNVNFDDTGWRQVKLLLRFGGLGLRSAVDLARPAYLSSLSSSHELIDEILGGSSQCFSGSLWISIASPLYYLLHNRVVAPGSTQCPLHLPVPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AZA8</accession>
    <name>A0A812AZA8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_7802</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000253">
        <property type="protein sequence ID" value="CAE1163783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AZA8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1163783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="153" mass="17922" checksum="A616E5732F7EF97B" modified="2021-09-29" version="1">MCTSSYLSGHHFFPMEEDYVDVRFIIISIYLSIYLSIYLSIYLSILLKQAKTFHFHDHNVLFYLSLTRTNTHTHYLSSSFFLSLTLSQTNTYSFSQFFLSLSCMSVFLSLSVYIYLSIYLSIDLSNYNFVIIYLSIHLSIYLPQSAHIRMSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B049</accession>
    <name>A0A812B049_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_7519</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000241">
        <property type="protein sequence ID" value="CAE1163053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B049"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1163053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="175" mass="20305" checksum="D5766911EEDDA192" modified="2021-09-29" version="1">MQYKMGLTLFSKPALEAHALFSAHHPHPTKKIILPSPFSIPVSPEHPNASRSPKLFLSFFLTIATFKSELALLQDQRQQSGTIPPFPLPPTTALQSFNRPRTFFLSFFLSFFLSFFLSFPSFLSLDPFLTSFFFFLFLSFFKHSFIPFFFLSLMSVLPILTYFFDIFFISFRFSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B0C5</accession>
    <name>A0A812B0C5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_10471</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000336">
        <property type="protein sequence ID" value="CAE1169108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B0C5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="427"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1169108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="550" mass="61229" checksum="D508F6C3EA8A0B52" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B0H8</accession>
    <name>A0A812B0H8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_8347</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000270">
        <property type="protein sequence ID" value="CAE1165195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B0H8"/>
    <dbReference type="OrthoDB" id="9942939at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1165195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="366" mass="40915" checksum="70FD2D3F949DCB36" modified="2021-09-29" version="1">MVPEEPTYMKVNVVTEEPTHEILMVPEEPTYTKVNVFYVVPEEPNLHESQCGYRGTNSLKFYVVPEEPTFPKVNVVTEELTLTEVLCGPRGTNLHESQCGYRGTNLTEEPTYVVPRGTNLHESQCGYRGTNLTEVLCGPRGTNLLNVLTYRKGPTCEFNVVPRGTNLLESSMCGPRGNQPTRKSCGYRGTNLTEVLCGPRGTNQPENEPTSTNVNVVTEELTSLKFYVVPEEPTYTKVNVVTEELTSLKVLCVLCGPRGTNLHESQCGYRGTNLTEVLCGPRGNQPTRKSTWLQRNQPLKFYGPRGTNLTKVNVVTEELTSLKFYVVPEKPTNTKVNGYRGTNLTEVLCGPRGTNLHEMSMWLQRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B1Q1</accession>
    <name>A0A812B1Q1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_9708</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000311">
        <property type="protein sequence ID" value="CAE1167904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B1Q1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1167904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="259" mass="30181" checksum="C25D9754F70DF381" modified="2021-09-29" version="1">MGGPPLAGKTDFFFSGPYLHHAIFLSRSLSFTHFLSFFLSFFLSFFLSFLISHSLEYLIHFIVFISIYLSIYLSIYLSIYLSQFVQICFTLFKAIYLSICSDLSIYLSIYLSICSDLSIYLSIYLSIYLSIYLFGSIYLCIYLFGSIYLSIYLSVRIYLSVRIYVSIYLSIYLSIYLSIYLSVRIYLSVRIYLSIYLSIYLSIYLFGSMYLSICSDLSIYVSNFYIPMLSLSLSLSLSVSLSLPLFLSFFLSYMFFLYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B601</accession>
    <name>A0A812B601_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_12095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000402">
        <property type="protein sequence ID" value="CAE1172415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B601"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="330"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="376"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="408"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="437"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="470"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="500"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="533"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1172415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="554" mass="65500" checksum="E630BBAC75E66B34" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B968</accession>
    <name>A0A812B968_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein uS9m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">28S ribosomal protein S9, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SPHA_13208</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000441">
        <property type="protein sequence ID" value="CAE1174630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B968"/>
    <dbReference type="OrthoDB" id="10254627at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000035">
        <property type="entry name" value="28S ribosomal protein S9, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_uS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US9M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="377"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00076042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAE1174630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="399" mass="46305" checksum="5993BFFDB5AF9214" modified="2021-09-29" version="1">MALNLTLSFIGGRCSRVFYSQSRISILGCIRHQSTIPSDISSVSKLVDTAKKPQPKAERISKAMVSYLEKAKKYDAMMLEEISQYEIGRRHLANIMGADPESFSQEDIDKAIEYLLPSALFAKPARPLMKHPYEIFPKKKMAQFGTDGRPFHYLFYTVKPNYYGLMHNIAWKVEELKKEEDKHYQVDGVFRNPPVLNLKGSTWIDKETLKKKVLENISDLEYQRFLQLIEHLVAQPFSYKEKEFIMQYRQEFESQLKQFNFPEIEIDENGRQFCKTTGKRKKAEVDLILWIKGSGKVEINGQDLSYFQSVKERNQLLFPLQFLQKTKEVDFKAEVRRGGISGQAGAIRLALSQALATFMDQATVEKMRLAGLLTRDIRRRERKKPGQPGARKKNTWKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BC75</accession>
    <name>A0A812BC75_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="16">SLC5A6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SPHA_14151</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Farmed</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>iodide(out) + 2 Na(+)(out) = iodide(in) + 2 Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:71207"/>
            <dbReference type="ChEBI" id="CHEBI:16382"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000480">
        <property type="protein sequence ID" value="CAE1176407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BC75"/>
    <dbReference type="OrthoDB" id="6132759at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015075">
        <property type="term" value="F:monoatomic ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098660">
        <property type="term" value="P:inorganic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11492">
        <property type="entry name" value="SLC5sbd_NIS-SMVT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018212">
        <property type="entry name" value="Na/solute_symporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051163">
        <property type="entry name" value="Sodium:Solute_Symporter_SSF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985">
        <property type="entry name" value="SODIUM-COUPLED MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985:SF2">
        <property type="entry name" value="SODIUM-DEPENDENT MULTIVITAMIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00456">
        <property type="entry name" value="NA_SOLUT_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="11" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="142"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="187"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="272"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="303"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="378"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="472"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00036099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAE1176407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="517" mass="56219" checksum="8582DEC7732C9755" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BMS7</accession>
    <name>A0A812BMS7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_20571</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000754">
        <property type="protein sequence ID" value="CAE1237077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BMS7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1237077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="413" mass="47963" checksum="797DFCFC234E5360" modified="2021-09-29" version="1">MFALLFSQTSVNFNLMFAFLFSDQCSLPVNFFWIPVFLPRQFLWNFLFFSDHAFYLSISLDVCLFFSQTSALLPVNFFETSTSALLPVNFFLMFSFFLFFSDQCSLPVNFFGCLPFFSQTSALYLSISLDVCLSFLRPVLFTCQFLWMFAFLFSDQCSLCFFDVWPFFSQTSALYLSISLMFAFLFRPVLFYLSISLMFAFLFSDLLFYLSISLMFGFLFSDQCSLPVNFFGCLPFFSQTSALYLSISCEPHPAEELLSFCRCLSCTLPTFLYLVNTTYVKFPSLFDHIELFLFILHFPTIFFPFLLLKKSFSILQLILSPSSHLLCKHPPPPPTTITTKEEEQEMNPAIYIFSSSSSTPPLQFSLSLHCYKKLTLLHIFCLCCFYFDEKICLLAQNFFCRSLFSLLLSYSHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BR43</accession>
    <name>A0A812BR43_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">SBF1_2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SPHA_23731</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Farmed</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000879">
        <property type="protein sequence ID" value="CAE1243239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BR43"/>
    <dbReference type="OrthoDB" id="74314at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20827">
        <property type="entry name" value="C1_Sbf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01235">
        <property type="entry name" value="PH_Sbf1_hMTMR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000286">
        <property type="entry name" value="PH-protein kinase domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020454">
        <property type="entry name" value="DAG/PE-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030564">
        <property type="entry name" value="Myotubularin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010569">
        <property type="entry name" value="Myotubularin-like_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807">
        <property type="entry name" value="MYOTUBULARIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807:SF109">
        <property type="entry name" value="SET DOMAIN BINDING FACTOR, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06602">
        <property type="entry name" value="Myotub-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00008">
        <property type="entry name" value="DAGPEDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51339">
        <property type="entry name" value="PPASE_MYOTUBULARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Myotubularin phosphatase" evidence="11">
        <location>
            <begin position="106"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="10">
        <location>
            <begin position="591"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="9">
        <location>
            <begin position="693"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="653"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="656"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAE1243239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="797" mass="91699" checksum="32260F6D91CB12AD" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BUX7</accession>
    <name>A0A812BUX7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_24568</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000918">
        <property type="protein sequence ID" value="CAE1245033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BUX7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1245033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="169" mass="20322" checksum="8DF17FAC07329F0C" modified="2021-09-29" version="1">MHRCSGTLFFFFFFFFFFFFFSFTRFLRLEPYVEFVHSLSCKYINPLLYLSIYLSIYLSHSVHIYHYVLNAWHQQQMNALFYVFLFSSIHFFFFICTFIHSFLSLFNHPFTFQSTSLPTFLLSNRHPHQHNTPYSLIGILTNTTPLTLQSTSLPTPLTHFVSKRRDKVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BVY9</accession>
    <name>A0A812BVY9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_25019</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000946">
        <property type="protein sequence ID" value="CAE1246149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BVY9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1246149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="169" mass="20046" checksum="4A0D7DA629D7E674" modified="2021-09-29" version="1">MTSFIPLLFLLFLYLSFISLIFLLFPFPFLYYPSLSFNLIHFVYSPSLSFIPLPFLLISLPFFDSHSLSFIPLPFLLLSFPFFDSHSLSFIPLPFLLFSFPFFYYPSLSFIPLPFLLFPYLSFIPLPFLLFHFCFYYSSYLSFILIPFLLLSFPFFYSLSLSFIPLPFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BXK4</accession>
    <name>A0A812BXK4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_28719</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001129">
        <property type="protein sequence ID" value="CAE1254006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BXK4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1254006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="156" mass="18794" checksum="FA285B8A3856B9AC" modified="2021-09-29" version="1">MVLSPTHRPLFSLFDSYFLQSVSYFYIFNIVLFLFILYTHSLHHFFFLFFIFTFSILFFLLLFLIHSFIFSLSCLCQFILAVCFFFLCIQFFQANLFLSGFLLITLSINIIIFYQIFTFYFSFKLSFSCSVHLQLFHYFFYSVNFVLHPLVPSSYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BYY4</accession>
    <name>A0A812BYY4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_25501</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000966">
        <property type="protein sequence ID" value="CAE1247113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BYY4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="324"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="349"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="378"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="411"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="442"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1247113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="510" mass="59496" checksum="AEAD01F82072B32E" modified="2021-09-29" version="1">MRPVVANSSPVVANSSPDVANSSPVVANSSPVVANSSPVVANSSPDVANSSPVVANSSPVVANSSPDVTIFFYYLTSFTPFLTVLLSSFFLSFFLSLFLFSFSLSFLFLFSFSFQSLFMSCFTIFFLSFFLSFFLSFFLSFINSFFLSSCFFHYYLSFYTPFLTVFLFLFFLSFSLSFIYFFLSFQFFFSIFLYVTPIFFLSFIHFFFLSFNHSFFLSFIHSVFLSSFFPSCFLSSFFLSFFLRAFFFIICLSLLHFLLFFFSYFFFLSVCLSVFLSFCLSFFLRTFFIIICPSILHFLLFPFSFLSFFLSLSLFLLFLSFFSVFLFSLSLCHAFFLSFIFLSFFLRAFFFIICLSLLHFLLFFFFFISFFLSFFLSFFLSFFVLLSFIFFISFSFLFLSLSLSLSLSLYLYIYIYIYIFISIYLSIYLSNSLSLHYLSIYLSIYLTLSHPTLSLSLYLSIYLSIYLSISTPLSLSRYLPNSLLSHSLSLSRSIHLSIYLSIYLSIYLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C0W2</accession>
    <name>A0A812C0W2_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_26460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001012">
        <property type="protein sequence ID" value="CAE1249173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C0W2"/>
    <dbReference type="OrthoDB" id="42382at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042609">
        <property type="term" value="F:CD4 receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050930">
        <property type="term" value="P:induction of positive chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00136">
        <property type="entry name" value="PDZ_canonical"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055287">
        <property type="entry name" value="IL-16-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48484">
        <property type="entry name" value="PRO-INTERLEUKIN-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48484:SF2">
        <property type="entry name" value="PRO-INTERLEUKIN-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="849"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="942"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="426"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="637"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="677"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="637"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="694"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="707"/>
            <end position="720"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1249173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1052" mass="114792" checksum="F36990A1B2B52241" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C1L0</accession>
    <name>A0A812C1L0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_26817</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001025">
        <property type="protein sequence ID" value="CAE1249836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C1L0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="144"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="185"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="228"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="257"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1249836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="283" mass="33044" checksum="A1459EC1F32018BB" modified="2021-09-29" version="1">MLQDMTFHYLNRNSSPPFGLYTWPTLAADRTNQPISAAAVGRPNFSSSSSSSSSGPTLLQQQADPTSAAAEHYMRQSFSGLAWPHDMRQTTKLRSYTTIILRTNRLHQHRLRRSSLFLNADALFTKGQTSGDRRDLEYRSLSPVLYSFFFSSSLLVSFFLFFFLAGFFISFFFPSLLVSFYFSSLLVSFFLFFLSLLVSFFLSFFFSAGFFLSFFFFAGFFLSFFSSLLFLSFFFFFFAGFFLSFFLSFFLCWFLSFFFLLCWFLSFFFFFFAGFFLSFFLLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C3N0</accession>
    <name>A0A812C3N0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_28846</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001136">
        <property type="protein sequence ID" value="CAE1254197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C3N0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1254197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="303" mass="36474" checksum="F85BBA955E33C424" modified="2021-09-29" version="1">MLWFVFPPSRRIMKGLYYAHTWLGSFRIYLSIYLSIYLSIYLSKMKNIFLIQSFLYEDVSRILIGEFLSSLQFLSFYFVVFFLSAFFIHHSFFFSFFLSFFLSFFLSFIICYIELPYLFVSFFLSFSVHMKPSSHPCNLFVRFFIAFSINMQPSAYLYILFASFFIRNPLLIYIFCFFFSVVSFFLSFFLSFFLSFFLSFLVHMNPSALLWIFFVCSFLCFFLSFFLSSNETSAHLYILFVYMFLSFFLPFSVCMKPSHHLYFFVRSFLCLFFLSIFLSFSVHMKPSAHPYNLFVSLFPFQFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C5P6</accession>
    <name>A0A812C5P6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_27503</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001068">
        <property type="protein sequence ID" value="CAE1251328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C5P6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1251328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="361" mass="42945" checksum="3DC68CF0D5460A15" modified="2021-09-29" version="1">MPKLTKSNVSDLLSFAVIFSLSIYLSIYLSIYLSIYLSIYRSIYLILFLSQSIHIYLSISVFSLSIYLFQYFHYLSIYFSLFISIYLSIYLSIYLSISLSLYIYIYIYISLYSYRILSLFNYLSIYLFHCYLSYISIYIYNVFPPLFLSISLFYLLICLYLSIYLSIYLSIYLSIYLRINLRKASNALVHFFLSFFLSFFLSFFLSLTLSILICSYLSQWFRMYQSQLGYIYLSIYLSIYLSIYLSMFPFNLFNLICSYLSIYLSIYLSIYLSIYLSISVCLSLSLSLSIYLFILICSYLSIYLNLVIIYFFISLSIYLTIYLSSYLSIYLSIYLSIYFLFLAIYLAISNTKLFFLSFFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C6J5</accession>
    <name>A0A812C6J5_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">NEDD8-activating enzyme E1 catalytic subunit</fullName>
            <ecNumber evidence="8 11">6.2.1.64</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SPHA_27908</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Farmed</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalytic subunit of the dimeric E1 enzyme, which activates NEDD8.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>ATP + [NEDD8 protein] + [E1 NEDD8-activating enzyme]-L-cysteine = AMP + diphosphate + [E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine.</text>
            <dbReference type="EC" id="6.2.1.64"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Protein modification; protein neddylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ubiquitin-activating E1 family. UBA3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.64" evidence="8 11"/>
    <dbReference type="EMBL" id="CAHIKZ030001097">
        <property type="protein sequence ID" value="CAE1252313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C6J5"/>
    <dbReference type="OrthoDB" id="5977743at2759"/>
    <dbReference type="UniPathway" id="UPA00885"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019781">
        <property type="term" value="F:NEDD8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01488">
        <property type="entry name" value="Uba3_RUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.520:FF:000001">
        <property type="entry name" value="NEDD8-activating enzyme E1 catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.20:FF:000001">
        <property type="entry name" value="NEDD8-activating enzyme E1 catalytic subunit, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.520">
        <property type="entry name" value="Ubiquitin activating enzymes (Uba3). Chain: B, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.20">
        <property type="entry name" value="Ubiquitin-like 2 activating enzyme e1b. Chain: B, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014929">
        <property type="entry name" value="E2-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023318">
        <property type="entry name" value="Ub_act_enz_dom_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030468">
        <property type="entry name" value="Uba3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033127">
        <property type="entry name" value="UBQ-activ_enz_E1_Cys_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF6">
        <property type="entry name" value="NEDD8-ACTIVATING ENZYME E1 CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08825">
        <property type="entry name" value="E2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01181">
        <property type="entry name" value="E2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00865">
        <property type="entry name" value="UBIQUITIN_ACTIVAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="6 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032464492" description="NEDD8-activating enzyme E1 catalytic subunit" evidence="12">
        <location>
            <begin position="23"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="E2 binding" evidence="13">
        <location>
            <begin position="401"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="10">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAE1252313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="494" mass="55616" checksum="40E7EB95FE053FEC" modified="2021-09-29" version="1">MAINIFFFFSSFTLLASPHTHTHVPTINDAGSVNFSANQSHFYLFFYLPGFFFTPNKGKDLFIIDNKMDSEWSDRWSHLKKILERTGPFTHSDFEPSPETFNFLQESFRILVVGAGGLGCELLKDLALLGVGNIDVIDMDIIDVSNLNRQFLFRPKDVGKSKAEVAAEFVNTRVLNYFDESFYRQFHMVVCGLDSIVARRWMNRMLVNLLNYEDGILDQASVIPMVDGGTEGFKGNARVITPGITACIECTLDLYPPQINFPLCTIAHTPRLPEHCIEYVRILMWPKEHPFGENVAIDGDDPSHIQWIYDKAIVRANVYSITGVTYRLTQGVVKRIIPAVASTNAVIAAACATEVLKIATSCCAPLNNYMNFSDTDGIYTYSFEAERKEDCLACSQIPQTLHFTEENKLRDIIDYLIESASFQMKSPAITTLISGKSKTLYMKTVKSIEEKTRENLKMSLKELGLSDGSEIYVADQTTPTSITFKLSLTSQMEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C7Z3</accession>
    <name>A0A812C7Z3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_31183</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001269">
        <property type="protein sequence ID" value="CAE1258298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C7Z3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1258298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="162" mass="19371" checksum="7CE174154874C1D3" modified="2021-09-29" version="1">MFLSFRKDFYLSLQPFYRFLILYTYTFPSLTIFLSLFLSFYPFLSLCLYLFHIHICCSFSLFLSFFVSIYLLIFLGMSLSITFYFSFYISLPIYFHYTCSLSLSPSLSLFYFDLFPFHYASLYIFLFLFRYPLPLSLSLSLSLVTFSHFVSQLKSQFLSLSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CCJ6</accession>
    <name>A0A812CCJ6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_32689</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001365">
        <property type="protein sequence ID" value="CAE1261372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CCJ6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1261372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="199" mass="23769" checksum="A8F2E9C33BDB2CD5" modified="2021-09-29" version="1">MITYIHMHMRVGFIYLLKTAHYLSIYLSIYLSIYLSIYLLKTAHYLSTAHYLSIYLSIYLFQVDLSISPRLVFFILCFLSIFFLCKFYSIFPFYTSRFLFSSFLSIHSFFCSFLPNFFVILSCFFPSLFGLPSIYLKFIYFFLLQINSVLSRLFLFFFPFIFSALSSPVLLFNSLCRSHQTSNDYFPWRWGSIKYTDGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CD96</accession>
    <name>A0A812CD96_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_33888</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001427">
        <property type="protein sequence ID" value="CAE1263811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CD96"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1263811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="248" mass="29251" checksum="B9AF1A96CC98EB43" modified="2021-09-29" version="1">MSQGQDEDYCKQNRCQSIDIYLSLFIIIYLSIYLSIYLSIYLKLFISIYLSIYLSIYLSILGFLVSIYLSIYLSISNYSYLSQTIHIYLSIYLSISDYSYLSIYLSIYLSIYLSSIIHLSQTIHIYLRLFISIYLSIYLSIYLSIYLRLFITIYLPMNRCCRNNSKSVDIYLSIYLSIYLSIYLSIYLSLWGQDGDDCKQNRCQSVDIYLSSIVHIYLSISKYSYLSIYLSIYLSIYLSSYLAIYLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CFN3</accession>
    <name>A0A812CFN3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_32666</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001363">
        <property type="protein sequence ID" value="CAE1261354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CFN3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="345"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="406"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="432"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="460"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="527"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="561"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="596"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="627"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="662"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="703"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="732"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="816"/>
            <end position="836"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1261354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="837" mass="89764" checksum="F0A3AA5971C8DE3A" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CG78</accession>
    <name>A0A812CG78_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_32971</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001376">
        <property type="protein sequence ID" value="CAE1261945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CG78"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1261945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="218" mass="25735" checksum="13C48380A6EC1DD9" modified="2021-09-29" version="1">MFFVLFSFLHVFCPFSFLHVFCPFFFPPRLLSLFLSSRFFVPFSFHLVFCPFFFSPYFLFLFPSSLFFVLFSFLLVFCPFFCRPCFCPFFLPLYSFLTLLFFPIFSHPFILCPSFFLDLNFLLHLLTSFSLSCFLSPCSHFLASLSLTLTFWVLFLLLSLSWTLFFSPSLFGFFFSPSHILASFSLLHLHASPPFSFCLSLSPLIFVFRYVKFTIQQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CGI4</accession>
    <name>A0A812CGI4_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">E3 ubiquitin-protein ligase RNF25</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">RING finger protein 25</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">SPHA_33126</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">Farmed</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the RNF25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="CAHIKZ030001387">
        <property type="protein sequence ID" value="CAE1262313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CGI4"/>
    <dbReference type="OrthoDB" id="432311at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16470">
        <property type="entry name" value="RING-H2_RNF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23818">
        <property type="entry name" value="RWD_RNF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000215">
        <property type="entry name" value="E3 ubiquitin-protein ligase RNF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000052">
        <property type="entry name" value="Putative e3 ubiquitin-protein ligase rnf25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039133">
        <property type="entry name" value="RNF25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13198:SF4">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13198">
        <property type="entry name" value="RING FINGER PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00591">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="18" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RWD" evidence="17">
        <location>
            <begin position="19"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="16">
        <location>
            <begin position="135"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="277"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="297"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="322"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="339"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="359"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="371"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="410"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="495"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="518"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="544"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="586"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="632"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="677"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="719"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="750"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="771"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="782"/>
            <end position="798"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00067354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00075535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CAE1262313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="830" mass="93075" checksum="C61D9324ED154460" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CHJ9</accession>
    <name>A0A812CHJ9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_34319</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001453">
        <property type="protein sequence ID" value="CAE1264682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CHJ9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1264682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="255" mass="29702" checksum="C4D4E0E02252FDB4" modified="2021-09-29" version="1">MTYVRSCPVGHRPSTLPQTPPLSFNHSVQWFNTETHARTTDITSQQMDGFLTRKPVARPLDTIQGLIKCDHAFTSGYIYSYLSIYLSIYLSIYRNLFIIYRSIDISLSIYLSIYLSIYLSIYQILFNMYLSQSVHLSIYLSIYLSISVCSYLSIYLSIYLSIYLSLILYLSIYLSIYLSQSVLFIYLSIIYLSYHLSIYLSCSKPFIYLGQYIIYLSISLFIYVSQTYHYLSISICSSSIYISSYLCHCQLSIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CHX0</accession>
    <name>A0A812CHX0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">GNA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SPHA_35596</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Farmed</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001536">
        <property type="protein sequence ID" value="CAE1267425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CHX0"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000720">
        <property type="entry name" value="Guanine nucleotide-binding protein G(k) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF231">
        <property type="entry name" value="GUANINE NUCLEOTIDE BINDING PROTEIN (G PROTEIN) ALPHA V1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0807">Transducer</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="196"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="233"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="295"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="324"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="556"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="601"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="630"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="671"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="698"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="751"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="489"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="489"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="499"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="509"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="99"/>
            <end position="100"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="124"/>
            <end position="130"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="149"/>
            <end position="153"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAE1267425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="780" mass="89131" checksum="F0DE400B1BC213F9" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CJ67</accession>
    <name>A0A812CJ67_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_35859</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001557">
        <property type="protein sequence ID" value="CAE1267883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CJ67"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="132"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1267883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="159" mass="15504" checksum="162A171003A76D47" modified="2021-09-29" version="1">MSATSTVPSDIASTSTSSCNVSHTSTVPSDIASTSASTPAMSATSTVPSDIASTSASTPAMSATSTVPSDIASTSAPPPCNYRSFRYSIHISLHPAMSATSTVPSDIASTSASTPAMSATSTVPSDIASTSASTPAMSATSTVPSDIASTSASSCIVSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CJ77</accession>
    <name>A0A812CJ77_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_36398</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001591">
        <property type="protein sequence ID" value="CAE1269005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CJ77"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1269005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="232" mass="27668" checksum="79F606D6AD1730FA" modified="2021-09-29" version="1">MRSCIHISIYLPQLPVNFHIYLSMFIIYLSIYLSIYLSIYLSQHVHYLSIYLSISACSLSIYLYIHTYIHSHLHILRFKHCFFCELKGRPNISMAIFVFMRVCVSIYLSIYLSIYLSIYLSISACSYVYSHFIIYLCFLCILLFIFLFLIFVFSALFSFQTFSHIVLSSFFSSSNTIFFYIYLFQFVYIYLSIAIYSYLSQSFHICLFISIYLSIYLSIYLSIYLSISVYKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CJ93</accession>
    <name>A0A812CJ93_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_35699</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001546">
        <property type="protein sequence ID" value="CAE1267621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CJ93"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1267621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="414" mass="47267" checksum="B0CD507F25BD9A04" modified="2021-09-29" version="1">MSLITHLKSSLITLITHLISTLLIHLKSPLIAYYTSQIPCYRLLHISNPLSSLLLNISYPLFSHISNPIIAYYTYQILSHHSSYTSHIHSSHTFQIPSYRLLHISNPLSSLLLNISYPLFSHISNPIIAYYTYQILSHHSSYTSHIHSSHTFQIPSYRLLHISNPLSSLFLHISYPLLSFFLIFFHSHISNPLLSLITHLKSSLIILITHRISTLLTHLKSPVIAYYKSQIPSYRLLHILNPLSSLSLHFSYPLFSHISNPLLSPITHLKSTLITLITHLISSLITLNTHLISTLLTHLKSPLIAYYTSQILSHHSYYTSHIHSFTHLKSPLVAYYTSQIPSHHPYYTSHIHSSHTSQIPSYRLLHISNPLLSLITHLKSSLITLVTHLISTLLTHLKSPLIAYYTSQILSHHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CKC0</accession>
    <name>A0A812CKC0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_36240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001580">
        <property type="protein sequence ID" value="CAE1268752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CKC0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="366"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="411"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="442"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1268752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="468" mass="54238" checksum="8853C7D26655E245" modified="2021-09-29" version="1">MIVYFLPIVYTHAIILFFCRGNFSLVSSQSLLSFYRFSIYLSIYLSLSAFSFFLTSYIFHPSFYPRLFALFSSFFTLLPLSLSLSLSSFSLPLSLFQASSYHVCPSVCLSVSLPLSLSLSLSLSLSVCLSLSFPFYLFSLSYGQNFYFVVGFFFLGFFSLFYLLISLSLSLSLSLSLFIYLSIYLSIFISLFFLFNNNISSTVFSLFSNICSTVFSFFCNICSTVFSFFCNICSTVFFFFQQYLQYCFFFFSNISRTIFPFSAISAVQFFFFFSNICSTVFSFFSNICSTVFPFSAISTVQFFSFYSNICSTVFFLFSAISTVQFFFFFYSTVFSFSCICSTIIPCSFICAVLCRPFQLHVQHSSFPFQFSTCFFFYSFLCFFFFFVAFFLSSYFPSFFLFYFSHSTFRHLFFFFSSSVNLFHFSARSFFISFVHTSSRFSVFLNCQLLTFSSCSTSFSFFCFYGCTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CLR7</accession>
    <name>A0A812CLR7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_41382</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001983">
        <property type="protein sequence ID" value="CAE1278634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CLR7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1278634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="268" mass="29560" checksum="74A430B3B17E1BB1" modified="2021-09-29" version="1">MLTISLSLSLSLSLSSLCSQFLSLVPLLTISSLSLVPLLTISPLSLVPLLTISSLSVPFLTISSLSLFLSLVTLLTISLSLSSLCSLISLSLVPFFFAISLSLVPLCFAISLSLSSLCSRFLSLSRPFARDFSLSLVPLHAIFSLSRPFCDVFRPNAIFSLSRPFARDFSLSRPFARDFSLSRPFARDFSLSRPFARDFSLFLFILLAVSLSLSRHFARDFSFSLSSFCSRFLFLSLITLRFLSLSPSSLCSQFLSLSSFCVKKIMNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CP49</accession>
    <name>A0A812CP49_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein SPEC3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SPHA_39622</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001855">
        <property type="protein sequence ID" value="CAE1275714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CP49"/>
    <dbReference type="OrthoDB" id="361532at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026673">
        <property type="entry name" value="SPEC3/Stum"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21676">
        <property type="entry name" value="PROTEIN STUM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21676:SF6">
        <property type="entry name" value="PROTEIN STUM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15795">
        <property type="entry name" value="Spec3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="203"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAE1275714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="247" mass="26890" checksum="734BA0BCB3C7CCD2" modified="2021-09-29" version="1">MEPLTSGRSIISFTTSQSSSQTRDELSSSPPIDMQVIYSGGSATPSPSPRALRKDMHTSGYIRPVMPAYVMRSLPPPSFAKCQSRVKPSDNKDATLRNVIPAMSKPVAVTCLVCNIFFPGLGTFISGLTLMCGSQVRPPEKTRSSIIWTNTWVAGLQLITTFLFLLGWIWSITWGIAFLSISDDYNSKIQAKNAMIDAAKNSCHRNGATSSNRGSNTTMRTTTTTTTNKKPADDVMIALRDTPTMPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CPI3</accession>
    <name>A0A812CPI3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_41210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001976">
        <property type="protein sequence ID" value="CAE1278337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CPI3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="315"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="375"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1278337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="487" mass="57099" checksum="F4E541979FA7CA16" modified="2021-09-29" version="1">MVAICNSIMAHVRDKDLKKENCCSEFIIPPLHLSSQFYRPFLLPFLLLVFFFLFSFSASSSFFFLCFFFFFFLSLLLFSFSASSSFFFLCFFFRFSFSASSSFFLSLLLFFFSASSSFFFLFFFFLFSASSSFFFLCFFFLFLLLLLFSFSASFFVSLSLLLLLLFSFSSSFFFSLSLLLLLFSFSASSSFFFLCFFFLFSFPVFCCFYCCLQLFFSFSFSLFFTLFFSLSLSLSLSKLLLYLRVYYSSPFIYPHNFIGPFFFLFSFSASSSFSLSLLLFSFLFRCFFFLFSFHGCCCCCCCSSSSSSSSSSSSLVFFTFCFSLSLLSSFAFFSVSLFPLFCLLYVHPPSSLVFISFLLLFLFPPPLRFSSQFYWSFLSLFIVFAYLIFFLFLRLSFFFFSSFFLFSFNFLISFCSLLFIFYSISNQVKGNSFSHFLFHTDPFSFSASDKFLYFLFDISFLPSSRILRLPQTIETNNNSYTIRIPHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CT61</accession>
    <name>A0A812CT61_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_44311</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002261">
        <property type="protein sequence ID" value="CAE1283877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CT61"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1283877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="292" mass="33607" checksum="8898F28F6268286B" modified="2021-09-29" version="1">MLSRLTFLSCFYLSIYLSIYLSIYLSIYLNLFISIYLSIYLSIYLSIYLSKYLSIHLSLIVYSYLSIYLSIYLSIYLSISICSYLFLQISISVCSYLSIYLSIYLSIIVCSYLSIYLSIYLSIYLSISIFCSYLSIYLSIYLSIYLSIYLSVCHSLFISIYLSIYLSIYLSICHSLFISIYLSIYLSIYLSIPSFSLTFNNIFTSTGHIPLFFFCGFISLSFSFLPSFLPSFLPSFLPSFLFQSNSSRSLHLPPNANVVSRRKSFPLPSSLTHSIIYLTIHSCDNKINSFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CUB3</accession>
    <name>A0A812CUB3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_42164</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002046">
        <property type="protein sequence ID" value="CAE1280127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CUB3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1280127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="153" mass="18060" checksum="99F63B29FCA00691" modified="2021-09-29" version="1">MYQSLPMDERVDVTILLLEVSRAIGFHARDVKKIYLSIYLSIYLSIYLSIRIFIALMYKHTVHFKKLLGCELRDQREILSIYLSIYLSIYLSIYLFVYNDIYLSIYLSIYLSIYLSQSNRFYESIYLSIAIFDPPLFISVLISISLLYISGQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CV75</accession>
    <name>A0A812CV75_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_44134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002237">
        <property type="protein sequence ID" value="CAE1283564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CV75"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="285"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="329"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="363"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="391"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="429"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="475"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="527"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="567"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="612"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1283564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="645" mass="77783" checksum="C57AF2DACE965740" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CYK2</accession>
    <name>A0A812CYK2_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4550 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_44041</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002235">
        <property type="protein sequence ID" value="CAE1283437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CYK2"/>
    <dbReference type="OrthoDB" id="188352at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027876">
        <property type="entry name" value="DUF4550"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33667:SF7">
        <property type="entry name" value="RIKEN CDNA 1810020O05 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33667">
        <property type="entry name" value="SI:DKEY-57N24.6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15084">
        <property type="entry name" value="DUF4550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032668672" description="DUF4550 domain-containing protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4550" evidence="2">
        <location>
            <begin position="139"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1283437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1203" mass="138798" checksum="227EFF16F5345BFC" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CZ34</accession>
    <name>A0A812CZ34_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">IGBP1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SPHA_43034</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002132">
        <property type="protein sequence ID" value="CAE1281737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CZ34"/>
    <dbReference type="OrthoDB" id="10261753at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051721">
        <property type="term" value="F:protein phosphatase 2A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035303">
        <property type="term" value="P:regulation of dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.540">
        <property type="entry name" value="TAP42-like family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038511">
        <property type="entry name" value="TAP42/TAP46-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007304">
        <property type="entry name" value="TAP46-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10933">
        <property type="entry name" value="IMMUNOGLOBULIN-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10933:SF9">
        <property type="entry name" value="IMMUNOGLOBULIN-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04177">
        <property type="entry name" value="TAP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="105"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="277"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="143"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="277"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="305"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAE1281737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="341" mass="39905" checksum="CEA698D6E533D1DF" modified="2021-09-29" version="1">MERQRGALLSKTETLAERQRELPSVRKTTKRWRRDNEELPFLPFKNTEKAIHMTNLLHLFSDNEDIDEVSTPSLKYLLLPALLNYFTMRKVGGERLDLVKKAKRAVISLFSPFFQFLSILTCLLISSLSLPFPLQEPDLLGMANQRQNKIDRYKEQKKTLQEIKELRVHIEKEHVEEEVQRKYYLLLLKNWISTALDDFENIKMELEILKQMAAMKAKGIDIAEEKKSGGFKKKPFRPFIITKDQLQKKVIGAGYPSLPTMTVEEFYEQKVKDGTFQLPTGSSLQDWATDPDKTSKDKEEEERNEEAKIEKDDAEKLSKMRNWDDWKDDVRRGDGNRMNMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D097</accession>
    <name>A0A812D097_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_43620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002201">
        <property type="protein sequence ID" value="CAE1282721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D097"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1282721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="208" mass="24735" checksum="67491CA35AF831A1" modified="2021-09-29" version="1">MKLKKNLIMRGLNIAWRQAISLVNSYSNLLLSIYIYLRHTLSFFFSLSLSPNLTIFVSLHLILFIFFCIFIQTSIHIFCSFFLFGVYFFIYFISLFKRSYSFVLVIYIFIQFIIVFLFLPLLFFIHSFVPSFLPSFLPSFLPSFLLVTSRLSNFLLVALSFILPYFDVFLCLMSCFFITSLYQSFHYLPQCFHYLSIYLSIYLSIYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D1U1</accession>
    <name>A0A812D1U1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_44319</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002262">
        <property type="protein sequence ID" value="CAE1283891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D1U1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1283891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="630" mass="72653" checksum="AF1F2A7E87E3B729" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D368</accession>
    <name>A0A812D368_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_46571</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002468">
        <property type="protein sequence ID" value="CAE1287425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D368"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032970240" evidence="1">
        <location>
            <begin position="21"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1287425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="199" mass="21446" checksum="8BA947218197F550" modified="2021-09-29" version="1">MPPLCLASSSLSFFLSFSLSLSCSTSSLFFPTRLSLPLPLFQSLSLSLSLSLSHSVVSPYLSFPLSLCRMIISPTLPFLLVSPLARSSLSLSLSLSLSLSPLFHSLFPTQSSLLLSLTFPLPPLSLFPLGRLSPSLFSALSFPLFLSFRSFISTHVSLFLSLSLAFPFSFPLTHLSLPLCPSLSLSLSFPPSLTHTVAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D4C6</accession>
    <name>A0A812D4C6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_49199</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002790">
        <property type="protein sequence ID" value="CAE1292293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D4C6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1292293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="172" mass="19237" checksum="A6AAD01E6209305D" modified="2021-09-29" version="1">MPTTSFPDRRAADRKCRGGKLSPIVAGRTGSGERCDGGAAHLADPIYHGGVIRAARRPCRHDARGRCDARPHRHDARHARRHARQRPDPARRRYEQLQPARRGRTPHPFTRTDRQVLNAPASPPRAGRVPCPKARSASHDGQRHTASHPRRYRAKSHPSLGQAFSTIRPPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D7H9</accession>
    <name>A0A812D7H9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="16">SLC30A5_7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SPHA_50104</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Farmed</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Zinc ion transporter mediating zinc entry from the cytosol into the lumen of organelles along the secretory pathway. By contributing to zinc ion homeostasis within the early secretory pathway, regulates the activation and folding of enzymes like alkaline phosphatases.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>Zn(2+)(in) = Zn(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29351"/>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002929">
        <property type="protein sequence ID" value="CAE1293972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D7H9"/>
    <dbReference type="OrthoDB" id="78669at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904257">
        <property type="term" value="P:zinc ion import into Golgi lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045316">
        <property type="entry name" value="Msc2-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45755">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45755:SF4">
        <property type="entry name" value="ZINC TRANSPORTER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0864">Zinc transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="15">
        <location>
            <begin position="37"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="15">
        <location>
            <begin position="101"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="148"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="166"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="185"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00046010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAE1293972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="361" mass="40944" checksum="FBD42F17B65485D1" modified="2021-09-29" version="1">MLPQHIHDREYRPGWYLKEKFYGWLRLIFSEKTSRNIFLFLLLNLSFAFVELIYGVWTNSLGLISDSFHMFFDCTALLAGLIASVISRWKSTETFSYGKLFFIFSEAVERAVEPPEVKHERLFTVSVMGFLVNLVGIFAFQHGHAHGGNDHGHSHSHGHSHGFGLQDEKDHNHEHNYNQHHGHSHDHGHSHDHGHSHDHDEGKSHSHESSSKISQKQIMQGVFLHILADTLGSVGVIISSGLIHQFGWMIADPICSMFIATLIAISVLPLLKESAGILMQRTPKQLDSLLPGCYQRVSQIEGVYGVQEPHFWTLCSEVYIGTLKLEVAEEADAKYILSQTHNIFTQAGVRQLYVQLDHKPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D8J7</accession>
    <name>A0A812D8J7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_50653</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002999">
        <property type="protein sequence ID" value="CAE1294927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D8J7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="301"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="359"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="387"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="427"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="452"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="483"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="509"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="546"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="575"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="601"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1294927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="623" mass="73541" checksum="CF3AD049B77ADCF7" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D8L7</accession>
    <name>A0A812D8L7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_48538</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002711">
        <property type="protein sequence ID" value="CAE1291002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D8L7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1291002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="351" mass="40481" checksum="D71E0B953569063F" modified="2021-09-29" version="1">MSAVNQRLTTEGHMASLSGILSSIYPSIYFIIYISIYLSVEVFVIYLYIYLSRYFVIYLSIEDFCNLSIYRGLLSYTSLSIYLSIEIICHLSIEVFCQLSIYLSRYFVICLSIKVVSFLSIYLRIIFQFVHLSKYLFKVIVLNLYFIPLCSFPSSFPLYSLFLFFFLSFFLSSFFLSKPCSSSFLLASTSLSPFEVLSNHFALSYPLWLPRYSAQACSIRPFHFNSSPFSHTREKEGKAEKLMRNAKSFYYTFGLNQSLFLSLSLSLSLSLSLFLSLSLTHTHTSPPLLFFSLSFSLPHSSAGIFYFPVLLSDFLFTISLYLSHSLSLSLPHPQCFKYQKQIFVSHSDNLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D9L7</accession>
    <name>A0A812D9L7_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="2">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">SPHA_49688</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="2"/>
    <dbReference type="EMBL" id="CAHIKZ030002877">
        <property type="protein sequence ID" value="CAE1293263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D9L7"/>
    <dbReference type="OrthoDB" id="6156543at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000020">
        <property type="entry name" value="Fibroblast growth factor receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170:SF54">
        <property type="entry name" value="FI24025P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170">
        <property type="entry name" value="PROTEIN SIDEKICK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="17" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="12 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-0675">Receptor</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="13" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="531"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="561"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="592"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="619"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="645"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="672"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="698"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="20">
        <location>
            <begin position="382"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="48"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CAE1293263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="720" mass="83869" checksum="4EACC9E5C8D1724F" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D9N6</accession>
    <name>A0A812D9N6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_49745</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002883">
        <property type="protein sequence ID" value="CAE1293325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D9N6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1293325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="234" mass="26156" checksum="B44F1DA1123191AA" modified="2021-09-29" version="1">MVHQPEYILRRPVGEVGGHFHSVSYPLAHRHAASSHTPSHFLSLKLSFSNSFSFSFSNSFSFSFSNSLSLSLFLKLTFTFSLSQTHFLRSFSNSLSLSLFLKLTFTFSLSQTHFHFLSFSNSLSLSLFLKLTFTFSLSQTHFLSLSLSQTHFLSLSLSQTHFLSLSNSLSLSLSLKLTVSLSNSLFSLSKNSLSLSLSLSQTHFLSLSLSLSQTHFFSLCLSQTYCLTFSRAMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D9U3</accession>
    <name>A0A812D9U3_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">SPHA_52381</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">Farmed</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CAHIKZ030003250">
        <property type="protein sequence ID" value="CAE1298034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D9U3"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120025">
        <property type="term" value="C:plasma membrane bounded cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004679">
        <property type="term" value="F:AMP-activated protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12122">
        <property type="entry name" value="AMPKA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14079">
        <property type="entry name" value="STKc_AMPK_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000079">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000236">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032270">
        <property type="entry name" value="AMPK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028375">
        <property type="entry name" value="KA1/Ssp2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049020">
        <property type="entry name" value="PRKAA1/2_AID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF110">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16579">
        <property type="entry name" value="AdenylateSensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21147">
        <property type="entry name" value="AMPK_alpha_AID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103243">
        <property type="entry name" value="KA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="12 15 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 15 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="337"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="371"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="400"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="432"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="466"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="504"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="590"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="616"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="639"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="721"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="760"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="792"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="827"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="18"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="19">
        <location>
            <begin position="645"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CAE1298034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1101" mass="128338" checksum="C6E24AF0180D1A1C" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DA06</accession>
    <name>A0A812DA06_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_47970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002651">
        <property type="protein sequence ID" value="CAE1290030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DA06"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="402"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="431"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="456"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="491"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="519"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1290030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="557" mass="65134" checksum="CC8A2B4A4F4736DC" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DAG7</accession>
    <name>A0A812DAG7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_48066</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002655">
        <property type="protein sequence ID" value="CAE1290355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DAG7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1290355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="328" mass="38243" checksum="F951F534ACFB4391" modified="2021-09-29" version="1">MFLSIYLSIYLSIYLSQSDHYLSIYLSIYLSIYLSIYLSHSVHMYRFIYLSLFAFYLSISVCSLSIYLSIYLSIYLSIPASSFLSINKSSNLTVSLPLFSLSFLLSFQLRSITHLSLYFSFLLSLSPTLCLSIYLSTNLTVYIYQSLFQSGYLPWHYLSIYLSRSYLSISLSLLVVISISRSYLSCYSVHIYQSFISIYLSIYLSSHESQDEYFSHFLSLMLNLNDHIYLSIHLSFYLSCYLFIYLLIYLSILSFISIYQSIYLSIYLSQPIPIYLSIYLFLTIYFSLSIYLSISALSLSIYLFICFSRFISLYLSISGQSDKRGEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DB47</accession>
    <name>A0A812DB47_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_53059</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003348">
        <property type="protein sequence ID" value="CAE1299192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DB47"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1299192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="171" mass="19304" checksum="D0DE57A86C44D97E" modified="2021-09-29" version="1">MFSFKSSIKSFLILLLLLYIFHFSYFLLSLLLHSNPSNFCCHFLLHLFNPKPPPPSSSSSSSSSSSSSSSSSSVTFPIFSTYFLFFHLNPPAIFNHSSSLSHFFTFFLFFLFLLYCIIQIPSLSFFLLLLFFHFFFHFFFVFFTSNPALFSPSIASSSSSSSSSSSSSSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DC46</accession>
    <name>A0A812DC46_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_50224</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002933">
        <property type="protein sequence ID" value="CAE1294141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DC46"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1294141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="281" mass="34111" checksum="C9CB05DB11FFEC36" modified="2021-09-29" version="1">MPLSFYLAFIFLIFHSLAILVSFFSSFLFSVAFFPSFFLSFFLSFFVPSFPSILSFICSFSFHFHSCILLYIFIFPFLLFSFFFLSFFLSSHVYLFFRSYFFFSFLFLSFFDFLFLSFFLSLISSFFLFFHFSFRSFFISLHIYFPFFLSFFLFLPFFVFFFLSFPFILSFFSFHSFFFLLLSFFLFSFPSILCFFFLSFPSILSFFLSFFLFLHIYFSAPTFSIISFFFLSFLYFHFRPSSTTVSYNYLCQIIQFLRLSKLKASLKLTLNTLYVVRKAFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DCE1</accession>
    <name>A0A812DCE1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_53337</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003390">
        <property type="protein sequence ID" value="CAE1299628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DCE1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1299628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="201" mass="23316" checksum="BD60825B16B0C898" modified="2021-09-29" version="1">MTVSPTIYLSIYLSIYLSISIYLSISVSSCLFLSLYLSLFIIFLTLLVCSLSIYLSIYLSIYLSIYLSQSVRIYLSFSHLLDLSLFMSVCLSVYLSISLSISVCQYLSIYLSIYLSIYLSIYSSLFISIYLSIYLSLFISIYLSQSVHIYLSIYLFIYLSIYLSIYLSLFVSIYLSIYLSIYLSIYLSQAVDIYLSYFHIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DGW1</accession>
    <name>A0A812DGW1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_51560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003131">
        <property type="protein sequence ID" value="CAE1296641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DGW1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="357"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="389"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="418"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="445"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1296641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="470" mass="56173" checksum="EAC1B80CD68818FF" modified="2021-09-29" version="1">MYQPPIISYNRDYQNTLSIYLSIYLSIYLSIYDSSSSIIGCSYLSMYHRIFLSIYLSIYLSIYLSIYASSLSIYHRILISIYLSIYLSIYLSISNIYVYLSLSFSLSLSIYLSVIDCLSIYYRLFISIYLSIYQSIYHRIFISIYLSIYLSIYLSIYLSMLVHYLSIMGYLYIFLCLFYLSIYLSIYARYLCLSLSVFLYLSIYLSIYLSIYLSVIDCSSIYYRLFISIYLSIYLSIYLCYSIHSLSVFLYLSLYHRIFMSISLCLYLSLSIYLSIYLSIYLSIYHRLFIYLSIIDFHYLSIMGYLYISLSLSFFIYLSIYLSIYLSIYLFMLDIYVYLSLSFSIYLSIYLSIYHRLFIYLSIIDCSCLSIYLSIYLSIYLSIYLSQDIYIYLSIYLSIYLSIYASSLSIYHGIFIYIYIYICLSFSIYLSIYLSIYLFMLVQYISLSVFLYLSLYHRIFIPIYLTIWCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DI68</accession>
    <name>A0A812DI68_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CACNA1G</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_52220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003225">
        <property type="protein sequence ID" value="CAE1297775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DI68"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1297775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="153" mass="18571" checksum="4CC1439B77ADCFF6" modified="2021-09-29" version="1">MVNIHIYLSIYLSIYLSIYLSIYLLKKQNITNKIHSLHTSYKWVRVEYPGPPVHRVGSGIPHHTSMISFTEQNKMVKRFSSISSFLFFFLFYSFFYSFFYSFFYSFFYSFFYSFFYSFFYSFIFLFLCSSNCFMNKFILHSVFLSFLISKLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DJ32</accession>
    <name>A0A812DJ32_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_54567</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003547">
        <property type="protein sequence ID" value="CAE1301666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DJ32"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="219"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="243"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="264"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="9"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1301666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="296" mass="34830" checksum="8E991BAD16EE8771" modified="2021-09-29" version="1">MCFVVGGLFTSIMKESPPSPEKSSYSKRMGIRKGKEGAGECPGKNPAPPTEQQSVAKQPTVQQPTVQQQAAAKKAVDQTPKDASEWQQVTRKGRKAATLPPSTQLEVSSGRKQQSPKQKPSQKQQQQQMQQQTRQQHEETQQRQEAQQCQQTQQQRQTQQRQEAQQCQQTQQQRQTQQRQEAQHDFVCFQETFFLSFFLSFFLSFFLFIFFLIPRDFPSFFLSLFLSFFLSFSVFLSYSKRQIFFLSFFLSFFLSFFLNPRERLAFFLSSFLFQETFFLFSRPPFFFRFSLFHFHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DK89</accession>
    <name>A0A812DK89_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_53875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003443">
        <property type="protein sequence ID" value="CAE1300415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DK89"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1300415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="194" mass="23363" checksum="26DC11AF72EC0DC0" modified="2021-09-29" version="1">MVHIVLSFILRFFLRFLLSFFLSFFLSFFFQFFLCFILSLLLSFFLRSLLSFFLFPSLVSFFLYFFLFPSVLPSLLSFFLLLAFFFLSSFFRFFLSSILSFAAFLLSFFLASFFLPSFVSLFLCFFLSFFLSFFLSFLAAFFLRFFLSFLPRFFFPSVLCFFLPFLASFFLSLFVRFFISFFLPTILFFSFFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DK90</accession>
    <name>A0A812DK90_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_53325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003387">
        <property type="protein sequence ID" value="CAE1299605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DK90"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1299605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="252" mass="30941" checksum="0691D77CBE48B9D5" modified="2021-09-29" version="1">MDHLGSKSNIFRELILPFFLSSLPFLSFFFLTFFLNFSCIHYFFFLYFILSCFIGFFLSFFLFFFSFFLINSYSFFHFFLSFISFFLSFFLSLRSYFPSNHFFVLSFILYFFSWFHSFILSSRLSFLLRIFPFIYYFHFIPPFFFLSFFLSFFFLSFFSFIISNFWCFLLSFIVFLSFLLFSSFFSFFISFVRSLFTFLISLHSSFLFSFFLSFFLSFFTFLFFLSCFFCSSFLVLLVTFFCLFVFPSFFLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DL31</accession>
    <name>A0A812DL31_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_53743</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003432">
        <property type="protein sequence ID" value="CAE1300282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DL31"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1300282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="186" mass="23119" checksum="F2AE987FFDB8FE05" modified="2021-09-29" version="1">MEQFRMRRKRREYFFLLFFFTLNCKLKQLLTFITSFFLSFISSRYLFPFLSFFLSFFLSFFLSILWYHFCSFSSFIPFPVILCVPFFFFLCFFALSFFLFFFHPFLLSFFLSFFLSFYFLSFLSFTMIYLWHFFFLSFLSFSFFLSFFLSFFLSFFLFPIIISVRFFSFFLSFFLPFFLSVLCLIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DME2</accession>
    <name>A0A812DME2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_57725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003900">
        <property type="protein sequence ID" value="CAE1305243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DME2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="431"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="488"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="534"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1305243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="645" mass="72014" checksum="B27B5F58220577D4" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DP20</accession>
    <name>A0A812DP20_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">WD repeat-containing protein 76</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SPHA_56453</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Farmed</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat DDB2/WDR76 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003723">
        <property type="protein sequence ID" value="CAE1303646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DP20"/>
    <dbReference type="OrthoDB" id="9890280at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000001">
        <property type="term" value="P:regulation of DNA damage checkpoint"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050853">
        <property type="entry name" value="WD_repeat_DNA-damage-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14773">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14773:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAE1303646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="506" mass="56035" checksum="C0E1CD350CFC905B" modified="2021-09-29" version="1">MNLSEYERKREENLRDNAQFMASIGIHQAKYELDLSIDSKKTRQKISVKSQLNASPKLKKVFQPTRRSARIQRIDPTGVPLPPVVIEEPVDVNPRKPPENLEMEDILSADCKKERHLQFANSLKSLTAPTHPLEENSSTSVSLKTFLQNFSKVQITEEQVRKVVKSRIFSVAVHPTVDKILVGAGGKWGAVGLWDVNQGLSEDAAVLYYPHSNPVNCLEFSRENPEKLFSCGYDGTLRCGHFEKKIFENIYYTPEDEGLLLRSFTFLSPHILIVSQSDGNVAFIDTRTEGYKAEEMFRASLRDVRTVDIHPTQPDYIITAGLDCALCLWDIRNMRKAPKKIFSASSGRMLNSAYFSPVTGKYILSTSQDNTLRIYDSSKLFLYISPLSHSPSSLSLPPLSLSLSSLSLSPSLSLSPLLTLSLSSSLSLSLPPLSLSPPFPLSLSLLLLPPSPLLPLSLSLLSLSPLLPLSLLLLSLSLLSLSLPPLSLSPSLLSPPLSHSPPLYIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DS35</accession>
    <name>A0A812DS35_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_61366</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004332">
        <property type="protein sequence ID" value="CAE1309675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DS35"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="284"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="321"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1309675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="346" mass="39692" checksum="89F686E8B4E4C0C7" modified="2021-09-29" version="1">MHVNGRMRPASRQLDTPGVSGLCGGLLLSVRGRLLSGCRRSLSLSLSLSLSLSLSLARSLSLPETLTKCMSFEFASFVCASFECPSSECMFSECPSSDCVSSDCTSSECRFLPDSPFLSFFLSFSFSFFLHCPSYTFYLSFLSLSLSLLFRFLFFSLFIILFSFPFLFISLSLHYFPSFFIFPFLSLPSLSLSLSLLISLSFFFFRFISPISLYLSFSIFLSFLPSFSFFFSLIFPLLSLSFSNFFICPFLSLSLTFFFFLFLSFLLLIYLLHLSIYLSIYLSIYLFVSIYLSYFFTFIFSFFLSFFLSFFLSFFLSPFSFLLVFILFLSFFLAFSGPFVLSIFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DSG4</accession>
    <name>A0A812DSG4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_60512</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004213">
        <property type="protein sequence ID" value="CAE1308691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DSG4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1308691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="261" mass="29617" checksum="922A10FA11548D91" modified="2021-09-29" version="1">MSDHIPVFCLSIFLSQSFTIYLSIYLSIYLSIYLSIYLSLFLSQSFSLSIYLSINLSIYLSIPIILSLSLSLSICLNHSLSLSIYLSQSFSLSLSIYLSQSFSLSIYLSISIILSLSIYISISIILSLYLYIYQSSQSILSLSIYISISIILSIYLYIYLNHSLSLSIYLSQSLSLSLSISIILSLSLSLSIYLSIYLYIYIYQSLSLSVYLYIYLNHSLSLSNYLYIYLSISIILYLSIYISTYDQCRPCAGCLQRAQGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DT31</accession>
    <name>A0A812DT31_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_59826</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004146">
        <property type="protein sequence ID" value="CAE1307840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DT31"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1307840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="211" mass="25170" checksum="474B3CB83FD62294" modified="2021-09-29" version="1">MRIGFLEFYRSISFCLSLFIFNGRSKYTYIEICFYLSKFISNLNLFLPIGLSINFHPGTVSSSPVVIYCIYIYLFPSGHYLSIYLSIYLSIYLHLFIICIYLIIYLLPYLSIDRFQSSVHYLSIIYLPIYHYLSIYHSLFYLSIYLSIYVHYLSIYLCLFITYRSHLFIIYLSIYVCPLSIYSSQSVHYLFIYLCIFYLGMSVSLSIYLFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DU23</accession>
    <name>A0A812DU23_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_58631</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004020">
        <property type="protein sequence ID" value="CAE1306352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DU23"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1306352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="251" mass="29007" checksum="422039F5A761BE45" modified="2021-09-29" version="1">MIPFISRELSVDVLIFHDFTLPANLSSLSFSLFLSLSLSLLLSFSFSLSLSFFLFLSLSLFLSFSLSLSLSFFFFLFLSFFLFLSLSLFFFFSLSLSFLFLSLSLSLLFFLSLSLFFFLSLSFFFSLFLFFLSLSLFFFSLSLSFFSLSLSLSFLSLSLFSLSFFFLSLSLTLTHTHTHTHTHITRCQSYLVQIEESTLLLVIVISITVIIVLSVSIFIIQYFFIRPKKNRILISLKQIVQEEEKFTPKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DXW5</accession>
    <name>A0A812DXW5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_63537</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004553">
        <property type="protein sequence ID" value="CAE1312295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DXW5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1312295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="202" mass="25124" checksum="04F2F582E998780B" modified="2021-09-29" version="1">MISFFLSFFFSFFYFLFFFFISFSLSFLFLSLFFISFFLSFSFFLSFFFLPSFSFFLSFFLFFFLSFFLFLFSFVFLSFFFFFFLFLLSFFFYLSFFLYSFSFLFLSYFLPFPFFLSFFLSFFVSFFFFLAFIFLHFLFVRLFFFLSSYSLPFFFHPDFISIYLSIYLSIYLSIYLSIYVNLCIFINLLIYDSLFISIYQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DXW6</accession>
    <name>A0A812DXW6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_61810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004391">
        <property type="protein sequence ID" value="CAE1310306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DXW6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1310306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="257" mass="29604" checksum="DFBAE738A8EBE488" modified="2021-09-29" version="1">MSLSTYSSLLIVVSRQTGRRCTAHRSHSSAGLLKVCALQLFHLYLYLSIYLSISVYSLLINLILFISIYLPHTVHIYLSIYLSVCLSVYLSICLSVCLGLFFINLSHSVYCFLFIYLFISVCTYLYRSTYHSIYLSISPLYLSVCSYLCIYLSNKSAHYLSIYLSIYLSIYLSIICALILSLSFDLFSQSYLSPSPAFISVCLCVWPYLSIYLSIYLSIYLSIWFYPCLNRPTLSCPIIYLSFSIYFNLIYSSILLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E0D0</accession>
    <name>A0A812E0D0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_65818</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004736">
        <property type="protein sequence ID" value="CAE1314824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E0D0"/>
    <dbReference type="OrthoDB" id="6022170at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.60">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1314824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="290" mass="32843" checksum="5E8F26BACB56DD5B" modified="2021-09-29" version="1">MELDSLTSVSVGYFGDDGKHNISVVLRIIDDQVLIGDLHKKVLDQLGVSEKCRPYFAIMEGKSRPSRKLKQTDKVKMSSNSKGLFLHKWCFDQDDEDKLLEDEAACNLIYNQAIFGLKTGRIVASIEEKMALNELSCSARPSKPAFIQLCRRLPGYYIVNVDNCLLNENSTLFPNTMNCVCKVSLSKNDLAITTENHIATICWKHIKQWSLQPSEPSLTYIITCFTDSMNNTTCDERILCLESEQLEYLLAATHEFIKNLQNLSHQNAFFGSMIRTEADGRVIWSNPLTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E0F9</accession>
    <name>A0A812E0F9_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SPHA_65482</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004724">
        <property type="protein sequence ID" value="CAE1314563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E0F9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="262"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="298"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="361"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="390"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="413"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="52"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAE1314563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="443" mass="51772" checksum="EA5C6202EC5B4747" modified="2021-09-29" version="1">MAVSGRSSSPQPYPCFYLSIYLSQSMCIRLFISIYLSISVFISIFPNSFLSFSLFVLFVLYFFPSFFLSFFLLFLSFFLLFLFFLSLNNFLSLFLILAFSLYFYPILFISIYLSIYLNLLLISIYLSIYLSISLNLLISIYLSIYLSQSVNIYLSFLISMYLSIYLAQSVNIYLSIYLSQSVNIYLIFNIIYLSIYLSISSIYLLISISLNLLISIYLSIYLSISLNLLISIYLSIYLSVCLSVCLSHYLSQSVNIYLSIYLSIYLSIYLSILVSSYLSFYSYLYLSLSRHATFSLPSFFLGFFLSFLSFSLSFYFSFFLSIFHSFLSINNFQSLPMAAFFSLFPSSTLSVNIYLSIYLSIFFFLSLSIFTFLYLTTLLFLYFLSFFLSFFLSFFLSFCFFFSPLFLSTCLSIFLSFFFLSIISLFPCPPFFLYFRLLHSFNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E354</accession>
    <name>A0A812E354_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_66923</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004832">
        <property type="protein sequence ID" value="CAE1316161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E354"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="362"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="394"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="428"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="455"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="496"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="522"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="554"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="587"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="623"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1316161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="671" mass="78341" checksum="938028A53A1484C4" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E4W2</accession>
    <name>A0A812E4W2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TSEN54</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SPHA_66312</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Farmed</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEN54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004782">
        <property type="protein sequence ID" value="CAE1315388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E4W2"/>
    <dbReference type="OrthoDB" id="408683at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000214">
        <property type="term" value="C:tRNA-intron endonuclease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000379">
        <property type="term" value="P:tRNA-type intron splice site recognition and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024337">
        <property type="entry name" value="tRNA_splic_suSen54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024336">
        <property type="entry name" value="tRNA_splic_suSen54_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21027">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21027:SF1">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12928">
        <property type="entry name" value="tRNA_int_end_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="319"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="347"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="390"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="416"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="472"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-splicing endonuclease subunit Sen54 N-terminal" evidence="5">
        <location>
            <begin position="87"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="219"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="226"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAE1315388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="516" mass="60715" checksum="2C4DF6C91E886FF0" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E4Z6</accession>
    <name>A0A812E4Z6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_65823</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004736">
        <property type="protein sequence ID" value="CAE1314795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E4Z6"/>
    <dbReference type="OrthoDB" id="6589648at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327">
        <property type="entry name" value="ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327:SF3">
        <property type="entry name" value="RNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1314795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="178" mass="20369" checksum="8352D133CAE32696" modified="2021-09-29" version="1">MARTEEALIRELFSNLTRDGRTPSQLLRFMKSPLGKNILKSLWLDRLPTTIIQILAPMSENTPLDQLADAADRIFSQLDHQTIPVHSAEASSDHGSLEKAVEDLQRQVRDLTFALKNRGRNRFPPRRRFRSRRRSSSRDNDTPSSTMCYYHRRFGSAARYCTKPCNYTAIAGNKTASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E5V3</accession>
    <name>A0A812E5V3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_67714</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004897">
        <property type="protein sequence ID" value="CAE1317037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E5V3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24216:SF65">
        <property type="entry name" value="PAXILLIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24216">
        <property type="entry name" value="PAXILLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="165"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="193"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="362"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="386"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="558"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="584"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="614"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="437"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1317037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="670" mass="76762" checksum="0F0C1431263C2B40" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E865</accession>
    <name>A0A812E865_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_68500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004986">
        <property type="protein sequence ID" value="CAE1317990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E865"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1317990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="204" mass="23640" checksum="57353F91DF1F86D8" modified="2021-09-29" version="1">MKKIQFNNRQFLSFFLFHSSHFFYFLFSYCLSLLFLFFSSFLLLLLILSSFFPHFFYLRILFPFLSFPFLSFPFLSFPSSSSSSSSSSFIFLPFLSYQISFRVFLVLILFSSFKGNKNLFSIFLRVSLSLSVSLSLSPYVFMRTILSFISLCVHSGLLAGVLSLPFLDTTIDPSHPICTHTHTHISIYLSIYLSIYLSILSIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E8C5</accession>
    <name>A0A812E8C5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_69907</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005110">
        <property type="protein sequence ID" value="CAE1319596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E8C5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1319596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="248" mass="29279" checksum="51BB30DD64F79A94" modified="2021-09-29" version="1">MQFLCLVSPLLFTFLSFFLSFFLSFLAISNFVLSTPLSSFHLSFFLSFFFFLSFFHAISNFVLSSLSSFHLSFFLSFFLSFFLSFCNFLCLVSPPLFSFHLSFFLSFFLFLSIQFVLSFLFSPFFLSFFFLSFFLHAISNFVFRLSHLFHLSFFLFSFFLSFFLSLPFSCLASLVFHLSFFLSFFLSFMQFLTLSCLASLVFSPFFLSFFLSFFHAISNFVLSRLSRLFTFLSFFLSFFLSFFLSCNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E9T8</accession>
    <name>A0A812E9T8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_67014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004836">
        <property type="protein sequence ID" value="CAE1316244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E9T8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1316244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="151" mass="17570" checksum="EC695796653E9901" modified="2021-09-29" version="1">MTTTSRVANASSFFSSFEGYLSVCDESNRNSGSKQRASSTESQHINNGFLYLSIYLSIYLSFYIFLFSLSLFLSVNFSLSLFFLALFLFVFLHRFFYFPLIPFLLFPRSFLPSFLLSFISFFLTRFIFYLFSLSLSLSFGLFTNQQCSFAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EBB9</accession>
    <name>A0A812EBB9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_69948</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005110">
        <property type="protein sequence ID" value="CAE1319595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EBB9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="327"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="365"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="395"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="422"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="455"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="484"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="523"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="547"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="628"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="651"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="679"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="732"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="760"/>
            <end position="782"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1319595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="813" mass="94978" checksum="DA6C24EB0F8AB637" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EC85</accession>
    <name>A0A812EC85_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_72472</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005327">
        <property type="protein sequence ID" value="CAE1322496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EC85"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        </location>
    </feature>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="304"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="371"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="396"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="423"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="454"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="485"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1322496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="507" mass="59206" checksum="EFD476EA0AD7A2F2" modified="2021-09-29" version="1">MSILFHSCSLFSLFSCSVFLIYSDNNLSIETSLFLFFFFYLSIYLSIYLSIYVILLFISIYLILFISIPVSSYLSIYLSIYLSIYLSIYLSIYLSNSLHIYPSQSLPIYLSIYLSIYLSIYLSILFISLSLSLSLSIYLSIYRSIYLILFISLHLSQSLHIYLSNSVHIYPSLFISIYLSIYLSIYLSNSLHIYPSQSLHIYLSIYLSIYLSIYLSIYLYSSSLSLSLYLSIYLSIYRSIYLILFISLHLSQSLHIYLSNSVHIYPSLFISIYLSIYLSIYLSIYLSNSLHIYPSQSLHIYLSIYLSIYLSIYLILFISIHPSLFISIYLSEELSNVLHIRSKCKIFYLCLSLSLSLSIYLNLSIHPLCYLSLSIYLSIYLSIYLSIYLNRFIAIYLTLLISIYLSIYLSIYLSIYLSLSKSSIIAIYLSIYPSIYLSSIYLSKSYLSIYLSIYLYLIYLSIYHLSIYLSIYLSIYLSIYLNLSYLSIYLSISIYLSIIYLSIYLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ECL0</accession>
    <name>A0A812ECL0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_71197</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005210">
        <property type="protein sequence ID" value="CAE1321019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ECL0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1321019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="206" mass="23800" checksum="340C0CC20BB36CD2" modified="2021-09-29" version="1">MQTVTDIKAYTLRLLHYILSCDFLYPLFFSSTLSRPNMFGQCISPPSTFFVNLYFLSLAFSIYLHLYLSIYLSIYLSIYLSISISIHIYINLSISISIYIYLSIPISIYIYIYLSIYLSIYLSIYSYINLSISISIYLSIPISIYIYIYLSISISIYIYINLSLSLSLSLSLAVTNHLTSFLSPHVNCFLPFMGNFPMTEVEDVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EG94</accession>
    <name>A0A812EG94_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_72569</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005331">
        <property type="protein sequence ID" value="CAE1322609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EG94"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134:SF22">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134">
        <property type="entry name" value="OS08G0543275 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="353"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="390"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="414"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="440"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="469"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1322609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="512" mass="59809" checksum="627F86A2BC2D5F02" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EHN0</accession>
    <name>A0A812EHN0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_75578</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005464">
        <property type="protein sequence ID" value="CAE1325981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EHN0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1325981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="187" mass="21894" checksum="05B71D27E2B16DE5" modified="2021-09-29" version="1">MSSIDEKPLSWFIRLIHDTCIHLNKSMLLLCLFQSNSTMSSIDEKPLSWFIRLIHDTCIHLNKSMLLLCLFHSNSTMSSIDEKPLSWFIRLIHDTCIHLNKSMLLLCLFHSNSTMSSIDEKPLSWFIRLIHDTCIHLNKSMLLLCLFHSNSTMSSIDEKPLSWFIRLIHDTCIHLNKSMLLLCLFQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EHZ7</accession>
    <name>A0A812EHZ7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FBXO21</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_72869</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005350">
        <property type="protein sequence ID" value="CAE1322970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EHZ7"/>
    <dbReference type="OrthoDB" id="28868at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.390">
        <property type="entry name" value="Hemimethylated DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011722">
        <property type="entry name" value="Hemimethylated_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036623">
        <property type="entry name" value="Hemimethylated_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032698">
        <property type="entry name" value="SirB1_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02097">
        <property type="entry name" value="yccV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31350:SF21">
        <property type="entry name" value="F-BOX ONLY PROTEIN 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31350">
        <property type="entry name" value="SI:DKEY-261L7.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13369">
        <property type="entry name" value="Transglut_core2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08755">
        <property type="entry name" value="YccV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00992">
        <property type="entry name" value="YccV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141255">
        <property type="entry name" value="YccV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemimethylated DNA-binding" evidence="1">
        <location>
            <begin position="425"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1322970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="547" mass="65490" checksum="F62DB48E19687AFA" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EIA2</accession>
    <name>A0A812EIA2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_74306</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005415">
        <property type="protein sequence ID" value="CAE1324540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EIA2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="301"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="392"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="430"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1324540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="571" mass="67424" checksum="19C9D2D6F39C7373" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EIP4</accession>
    <name>A0A812EIP4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_73863</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005398">
        <property type="protein sequence ID" value="CAE1324055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EIP4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="296"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="398"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="427"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="457"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="482"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1324055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="517" mass="63247" checksum="277A069CD6F80453" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EL72</accession>
    <name>A0A812EL72_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Helitron helicase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_75961</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005478">
        <property type="protein sequence ID" value="CAE1326423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EL72"/>
    <dbReference type="OrthoDB" id="1728974at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786:SF74">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786">
        <property type="entry name" value="DNA BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helitron helicase-like" evidence="2">
        <location>
            <begin position="531"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1326423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="803" mass="90869" checksum="507E496C14DD7008" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EME2</accession>
    <name>A0A812EME2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_75830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005474">
        <property type="protein sequence ID" value="CAE1326260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EME2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="285"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="316"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="347"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="379"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="408"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="437"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="460"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="484"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="516"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="541"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="574"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1326260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="611" mass="74722" checksum="76F514BA1D323F23" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EMX0</accession>
    <name>A0A812EMX0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TAF9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SPHA_73724</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005388">
        <property type="protein sequence ID" value="CAE1323951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EMX0"/>
    <dbReference type="OrthoDB" id="341924at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07979">
        <property type="entry name" value="HFD_TAF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000018">
        <property type="entry name" value="Transcription initiation factor TFIID subunit 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003162">
        <property type="entry name" value="TFIID-31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051431">
        <property type="entry name" value="TFIID_subunit_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48068">
        <property type="entry name" value="TAF9 RNA POLYMERASE II, TATA BOX-BINDING PROTEIN (TBP)-ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48068:SF4">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN ASSOCIATED FACTOR 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02291">
        <property type="entry name" value="TFIID-31kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="199"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="218"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="233"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="252"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="267"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="283"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAE1323951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="321" mass="34274" checksum="7E229A4D032AA049" modified="2021-09-29" version="1">MAVPKSTPRDAQVMAAILKDMGVQDYEPRCVNQMLEFAYRYVTDVLDDSKVYSSHANKKTIDGDDVRLAIQCRMDHSFTTPPPRDLLMEIVRNKNSQPLPLIKPYSGPRLPPDRYCLTAPNYKLKSTKKHKLPLNLPVNQYSTTSIPSQRISLTPLQQNIAVSGKIGSGIGLSGSNNPTLTVVTKGVSLPTVTIVSKPVSTPSPAITPKPTIRTTIGPKPSSTSVSSGPSMPLGQTVTVTSSSIVPGSIGVTTPSITSSSSTSTSVPHPPPPPPPPPPPPPQNISLNQMNTTQIVTSAPSVPGTQTNSLKRKLSDDDYDQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EQ43</accession>
    <name>A0A812EQ43_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">OLFR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_77253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005511">
        <property type="protein sequence ID" value="CAE1327850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EQ43"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1327850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="226" mass="25900" checksum="9E0F5B14AEC59C60" modified="2021-09-29" version="1">MDYYSKPDFYIIAFVNILLSLSLIIFSLFLSLSFFFLFSLFLFTSVSFGSFCLSVSISLLSLSFSLISFVYSLSFPIFCVTHFYFFLSNLLFIAIYSFFLFILCFSFFLSLFLYFAFIFFLSVSFSLFLSLISLSFTLSVFLFCLSLLSFVSFCLFSLCFLILSSFSSLSLSFISLSLSLFISLPLSLPICYGRYLSVCSYLSIYLSIYLSIYLSVSVYINLSMDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EQ84</accession>
    <name>A0A812EQ84_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">palmitoyl-protein hydrolase</fullName>
            <ecNumber evidence="2">3.1.2.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SPHA_77343</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Farmed</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.22" evidence="2"/>
    <dbReference type="EMBL" id="CAHIKZ030005515">
        <property type="protein sequence ID" value="CAE1327923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EQ84"/>
    <dbReference type="OrthoDB" id="2418081at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050565">
        <property type="entry name" value="LYPA1-2/EST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655:SF68">
        <property type="entry name" value="PALMITOYL-PROTEIN HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="198"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="228"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="5">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAE1327923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="268" mass="31631" checksum="97D86755BD3ED9B4" modified="2021-09-29" version="1">MTSWFDIRGLSPDSPEDEEGIKEASQRLKELIEKEESEGIPSNKVVIGGFSQGGAVALYTAFTLSKPLAGVIALSSWMPLNKQFPGVVKGNQSTPVLQCHGTADHVVPFQWGTLTAKLVNSFNCKHELKTYQGVMHSSCPQEMIDHNFFFLFSVFSFFFIPSSFLLLFFPSSFLSFFFSFLLLFFFFFFLFFFPSFLFFFFSSFLFLFFFSFSFLLFFFFFFSFSSSFLFLLLFFFFFFSFLSFYFFFFFFFFFFFHKKFNHKNSHYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ESX1</accession>
    <name>A0A812ESX1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_76815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005498">
        <property type="protein sequence ID" value="CAE1327387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ESX1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="295"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="327"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="360"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1327387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="392" mass="46686" checksum="86D1FEA3D730DFC8" modified="2021-09-29" version="1">MASSQNGRKYMSVLRVLWGAVYYFSFSLSLSQPLTLMRTLFLSISPACFFFIFSFFLSFFFLACFLFSFFLFFTFLFPYFFLFLFSFFPAFPFFIPLFSSFLLLSCFFFLSFILSFFLSFLLFLPLFLSFFLAISSFLSFFLSFFLSCFFFLSSYLSFFLSFFLSFFLSFFLSFFPLYPFNLFIIYLSIYLSIYLILFISIYLSIYLSIYLSIYLSQSVLYLYIYLSFPEPINVYRFPMGLLLLSFFLSFFLSFFGHTFLPSSISFFFWSSLPPFLHFFLSFFGHPFLPSSISFFFLSFFLSLVIPSSLPSFLSFFLSLVIPSSISFFLFFFLSFFLSFFLSFFLSFLPTNTHLRYFSPLLWFVYLYSSLFHFPSPFSLMTFTLSLLSHPIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ET23</accession>
    <name>A0A812ET23_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_78336</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005535">
        <property type="protein sequence ID" value="CAE1328681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ET23"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="302"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="336"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1328681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="407" mass="48728" checksum="9CC0D4BB352409BD" modified="2021-09-29" version="1">MKLFHIYLSIYLSIYLSIYCSLFIIYLFQSVHYLSIYLSIYLSIYLSISVCSLSIYLSIYLSIYLSIYLSMYFKIYLYLSIKWYKEDKKENIATSTFISSFFLTLFLSAFLSLSIYLSIYLSFTDYLSIYLSLTVCLYVQNISIVIIKVYIDLSIYLSIYLSIYLSITDCISIYLSIYLSIYLSLTIYLSIYLSIYLSFTDCISIYLSIYLSIYLSIYLSLTVCLYVQNISIVIIKVYTDLSIYLSIYLSIYLSITDYLSIYLSIYLSIYLSQSVHIYHSFFFIFSFFFLPYYFYFFSFNSLFYSFFLVLSTLSHSFFNLAIFFFFIFIFSSFIHFFLSFFSFFLSFFLSFFLSFFYLCILFRLSCSSFFRSFFFLPSFLSLFLSFFISFLSFPSYKNIFFLFPNYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EW77</accession>
    <name>A0A812EW77_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_81396</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005632">
        <property type="protein sequence ID" value="CAE1332362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EW77"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1332362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="210" mass="23730" checksum="B9416E83AA9EB5BC" modified="2021-09-29" version="1">MPLPSKFLFSISYKYIPFPNSLSLSHTLSLSMKLSMELVHLSLSLSLSLSLSLSLTKHTNTLSLSLSLSLSLKLVRLFQTKLALSFQFCVFFNFYKYISFLHFLSLSLSLPSCSIFLSHTRRLSFFSPLSLSPLSLSLSLSLSLSLWEDSSSFSNENPTPSFQTFVFPFLINTSLSFSLSLFLFLPLKLVRFSQTKLISLPPTVVFFLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EWI5</accession>
    <name>A0A812EWI5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_81600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005639">
        <property type="protein sequence ID" value="CAE1332557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EWI5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1332557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="266" mass="32586" checksum="8B1F839169C26396" modified="2021-09-29" version="1">MTFSFQFFNHFLSFFFFYFFLFLSFFLFPFVLFFFFQFFLSFSSFFLFPFFLFLFLFFLFLFSFFFHSLFFLSFFHFPFFLFFPSFFPFLFFLSFILSFLSFSSFFLFSILSFFFPLSLILSFSFFFYSFFFFFLSFFILGFSFFLSFSILSFFFPLSFIFYSFFLSFSLSFRFPLSFFFPFFLSFFLFLSFFLSFFLSFFLSFFLSFSSNHFCNTFSVPLMSFVSTLGFSLSFFVSFVSFPFPFGFLSHPCVSFLVSPFISFSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EXP7</accession>
    <name>A0A812EXP7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_81310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005630">
        <property type="protein sequence ID" value="CAE1332248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EXP7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="309"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="351"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1332248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="377" mass="43922" checksum="1D47660047878666" modified="2021-09-29" version="1">MNKCSCRCLMNWQRFCCDVGMSVCRSHFLTTILSTFSFLFSLSSTPYFLPILSFYSIPFLHSLSLTFMHFVPPFHTFFDFLSTPILQNIYFFIPLIFLFSSFLIHSFFYLLFSNSFLLSSFLLLFPFFFLSFVFLLLLSSTFSFPISSLSLSFSLSSFFSLSHLFLPFPSFLSSPFAFFFPCSLSLFFLFLFFLSNLPLLLICLSPSFNISIVFSFFSHLQLFTQIFLFSFICCSFLSHLPPLVSFLSLSIFLSFSLSISFSLSIYLFLSIYLSISFYLSISFYLSIYLSLSIYLSISIYLSISIYLSLSIYLSIFLSLSIYLSFSFYLSFFLSTLFFVSPQFFPYINFHYSLLTFIPFCFLPPPFILFLPPFFFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EZ75</accession>
    <name>A0A812EZ75_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_81293</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005630">
        <property type="protein sequence ID" value="CAE1332240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EZ75"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1332240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="301" mass="35177" checksum="D2918C73B46FE70E" modified="2021-09-29" version="1">MARLKASAFFFFFFTQQQLSLSSSSSSSGRDTAAHQSMRVCARFHLLPLLLSLYLFNPLPLLLAIHFLSFPSLYLYRFSPLFAFHLLYLTLLPSLFFYYSSSFFTFFTPPHFNFIHLFLLHLFLSLSFYLYICLSLSFSLSPPLSLSLSLRDMSFSKVSFISLSMIPCIFSLLTLFSSSFPFPLFVLPTLFLFLPPFSFCSPPTVYHPTTFLPHPLPQVNVTLLQPFFFHSFSYHFLIYLSIYLSIYLSIYLSIYLSIYLSIYFRLFIIYLSIYLSIYLSIYLSILFIFLPFSISLSFFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ALC4</accession>
    <name>A0A812ALC4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_2532</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000070">
        <property type="protein sequence ID" value="CAE1148746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ALC4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1148746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="211" mass="24378" checksum="9B80C8A76EE904AD" modified="2021-09-29" version="1">MIFDSFCLNLSQPIIIYQSVSIIPFLSLFIQFCSYFDFFSLSLCIIVSFFETSYLSFYLSWDLYVYFSLFPSLAISACFFLSINLFQLISFSLMFISIIVCFFFIGFFLCLFPSMVICLYLAITVSVFLSIYLSLFISTESIPLYLFFSVCFFLSLSFFLYIKLFLSFDSHQSVSVLLCFFLCICPTLFLSILICFFGSVSITICLNLSAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ALJ4</accession>
    <name>A0A812ALJ4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_1086</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000029">
        <property type="protein sequence ID" value="CAE1142611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ALJ4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1142611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="213" mass="25939" checksum="F524C8389860D2B5" modified="2021-09-29" version="1">MWHSEDSPFHNFRIIQRARLLLDVKHTPISIKLDATSSNCSFLSPPYFQPCLFYPLSSFSSFFFLFTFFFSFFLFSSFFFLSFYIFLLFIFLSFFLSFSLILSFFFPSFLHPFFLSFSFLSFFLFFLSCFLLSFFLFRSFFLLFFCSFSFFLYFSFLLSFFLFSSFLFSFFLSFFLSFFLLLSFVLFSFFFPSFFLSFFLSFFLSFFLSFFLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AP39</accession>
    <name>A0A812AP39_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_2853</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000083">
        <property type="protein sequence ID" value="CAE1150210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AP39"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="295"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1150210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="339" mass="40015" checksum="3B30F8D625A39A9E" modified="2021-09-29" version="1">MSPIKKVFAVYGPPILSLQTNCGPRTTATRHAIIGGDEKARSLSLSLSRARTFLSESPTTNIVQRAHSPPSLPHPVTITATNRSLLRQLQSLRCCCCASVASTGVSIPSASVAVYARVLPNLSLSLSLSLSLDNHKCRKEIRVVLSLLFLSFFFLLFLLLSLLFLYLLYSFRLFFLSFLSFLLSLRLTFFLSLRLFFLSFFTSFLSFFLYVFSFFLSLRLFFLSLRLFFLSLRLFFLSLRLFFFLSFFTSFFFFLFLFYVFSFFLFFLYVFSFFLFFFTSFLSFFLSLRLFFLSFFLYVFSFFLFFLYVFSFFLFFLYVFSFFSYLPFHLKKKQLKQYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ARX9</accession>
    <name>A0A812ARX9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_2909</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000083">
        <property type="protein sequence ID" value="CAE1150088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ARX9"/>
    <dbReference type="OrthoDB" id="6161790at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1150088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="180" mass="20709" checksum="F7B26841FC6E27D1" modified="2021-09-29" version="1">MIVWPEQAVVGKGMGDSRLLEFTSSKHSNSKAIDVRFCHLSPLSLSLSLSLSLSLSLSLSLSLYSSILFFLYFFIPPALLCSVHIYLSIYLTQSVHLRLFIYRIIYLSPNFPVCLSIYLSIYNNLFISIYLSIYLSIYLSIYLSNTTLLLFLFLRPRLRSSSFFLSFFLFLFIPSSNRLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AS39</accession>
    <name>A0A812AS39_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_2852</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000083">
        <property type="protein sequence ID" value="CAE1150284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AS39"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134:SF22">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134">
        <property type="entry name" value="OS08G0543275 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="383"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="427"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1150284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="578" mass="66219" checksum="50284DD12ACB97AC" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ASC5</accession>
    <name>A0A812ASC5_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_4543</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000145">
        <property type="protein sequence ID" value="CAE1155752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ASC5"/>
    <dbReference type="OrthoDB" id="444601at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000063">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF7">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="5"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="310"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1155752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="367" mass="41430" checksum="6B26F9EF01522D85" modified="2021-09-29" version="1">MPHEIPVRPWQIVATDIFNLNRHNYLLVVDYNSKYPFIRKLKEFSSKEVIDFTKRIFAEQGVPERLTSDSGPHFSSRHFKEFAKAWDFEHITSSPKYPPPRSNGMAERCIQTIKGAMKKAMLSNRDVDMSLLCLRLTPMDHVIPSPGKLLFNRKLVSNLPTKCTNNNARKEEIQDRLLDRQWLQGKQHDQHAKDLSKLSTGQLVRVQEQDTRKWTSAVVRQICTEPRSYIIETPTGQVLRRNRRHLKEDISNKALTSLHSTSLPPPANIPNTPPAGTPNTPSNICTPSKATLTNSSHPSTPLSRNTSQLKTSSAKKATPSTASAQIHFSHPSTPLSRDSIQQKPSPFKKAISSTSTDTYFPSFNSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ASG2</accession>
    <name>A0A812ASG2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BRAP</fullName>
            <ecNumber evidence="9">2.3.2.27</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SPHA_5920</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="9"/>
    <dbReference type="EMBL" id="CAHIKZ030000195">
        <property type="protein sequence ID" value="CAE1159376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ASG2"/>
    <dbReference type="OrthoDB" id="273556at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16457">
        <property type="entry name" value="RING-H2_BRAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12718">
        <property type="entry name" value="RRM_BRAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000159">
        <property type="entry name" value="BRCA1-associated protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011422">
        <property type="entry name" value="BRAP2/ETP1_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034932">
        <property type="entry name" value="BRAP2_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047243">
        <property type="entry name" value="RING-H2_BRAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24007">
        <property type="entry name" value="BRCA1-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24007:SF7">
        <property type="entry name" value="BRCA1-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07576">
        <property type="entry name" value="BRAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="323"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="UBP-type" evidence="8">
        <location>
            <begin position="360"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="77"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="504"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="78"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="148"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAE1159376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="670" mass="75494" checksum="C00431EE57C63496" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AUW0</accession>
    <name>A0A812AUW0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_6212</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000203">
        <property type="protein sequence ID" value="CAE1159986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AUW0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="440"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1159986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="476" mass="54711" checksum="907ED8E39ADD73D8" modified="2021-09-29" version="1">MKHLSLYLFLSLSLSFFCSLSLFLFFLSLSLPVFLSFFLSLSLSLFLFLSFCLSFFLSISFFLFLSLYLFFFLFFLSFFLSLSLLLSFSFSLYLSLSFFLSIPFLFLFFFLSLSLFLSFFLSLFLSLFLSLFLSFFLSLSFFLFLSFSLSLYLSLSFFFFFFFFLFSFFLSLSLSLSFFLSFFLSFFISFFFLSFFLSFFLSFPPSICEYFSSHRLLLLISFFFFFSPPPPPPPPSPPSSSSSSLYPSPSYLSSSSSCDVIKRQDDVISFRRNRSGRGVAAKAVPAGSFSLPSACLAVPDSASACRLRPVVRFSPFSSVRPVSVPPRFSRRREMTQGAQALVAGGELTGVQPQTFSLAMVRESRFNSSSSFFLLLLLLLLLLLLLLLLLLETKQHSKTTDDKRKKVKEKTTDVFRKKKSKLLLTDMWIKYSSSSSSSSSFFFFFFLSSSFFFFFFFLHCFFFFFLSSSSSSSSSRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AUY2</accession>
    <name>A0A812AUY2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_5484</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000181">
        <property type="protein sequence ID" value="CAE1158046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AUY2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1158046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="298" mass="33987" checksum="C19B3925DC2404E3" modified="2021-09-29" version="1">MFNCYLLLLIYLFLSPPLFIYPFLSPHLISIIVSPSLYLSVSISLSLCLSLSLCFILSPSPSIYMLLSSSLYIYIFFYLPLSIYQFVCHSLTLSASISLFLDINFYLTLSLFICFYVPPYACVSIPLSLYISFYRFLHIYISISCSLYISACISSISLFLFSIPLSLTLSAPISLSLDISFYIPPSIYLFLCPSLYMYLFLSPSLYISVSTTFSIYIIFYLSLPLSLSTYVYICFYPPLSISLFLCSSLYIYICLYASLSIYLLLSPSLYISVSMFLYIYISACMPLSLFICFYLPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AVB5</accession>
    <name>A0A812AVB5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_5047</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000168">
        <property type="protein sequence ID" value="CAE1157101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AVB5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="404"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1157101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="445" mass="52140" checksum="A00D8A06F41D7C9E" modified="2021-09-29" version="1">MFIRFLFFSLSVFSLSLSFSLTLSLMFILSFFLLFFIYLSILFHLFPVYFSFTLSLFLSLTLSFSHSFFLSFFSFTFILFLFFSWPFFNFSFLNSYFLSFYLVFFSSTPTLLFSVTYCLRTLFLTRFLFRLLSILLSLSLSLFFSLSIYLFLSLSLFLCKFDVLSLCFSFRIFLLLLSIYLSIYLSSRSLPFSVPQTFPFILLRMLCLFLSFHPPISISLPLSLLFSFLLSLSLALSLPLSFFLSIQFSFYPDEVSPLIPVSIFLFSYTFTRSFILSLSMYLSLPHSLYLILFSLVALHFQCLFIYVCFFDHYPKCPMLFSQKLSFPRCISSLSLSLTHSHSLSLSISLPPLSLSLSLSLSLGMSPENSSSSISSSYFTFHIFLFLIFLYLFCFPIFYYTFIDLLLLLLLLLLLLLLLLLLLLRRRRRRRRPFFFLSFLFSSSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AW78</accession>
    <name>A0A812AW78_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_5478</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000181">
        <property type="protein sequence ID" value="CAE1158040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AW78"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1158040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="245" mass="29060" checksum="CEF18E60522B0DE3" modified="2021-09-29" version="1">MISLFTLFFIFIYLSIYLSIYLSIYLSIFWSLPLPLSLSLSLSLSLFVYTAQIIRSYLSIYLSIYLSIYLSIFGIENDSTVSISRRYATKHTRFFYLSIYLSIYLSIYLSISRFIISLSIYLAIYLSIFIYISIYPNLFIIYLSIYLSMLRVHYLSLSIYLSIYLSMFVHYLSIYLSIYLSIYLSPIYICLYEYLSIYLSIYLSIYLSKTVPIYLSIYLFNTSLCPGIHFFTPVKYTHYLLIHSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AX55</accession>
    <name>A0A812AX55_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_7386</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000237">
        <property type="protein sequence ID" value="CAE1162701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AX55"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="344"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="381"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="415"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="447"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1162701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="474" mass="54200" checksum="979B1DCC96C2B2A9" modified="2021-09-29" version="1">MPLSLSLSLSLSLSLSLCPKPMLFVLKNRTYTLNYSLYPSLPSTSRAFLHLSMSDLFNIYLSIYLSIYLSIYQSESVCSYLSVSVCSYLSQSAYMYRFIIYLFICVSLKDLSIYLSIYLSIYLSIFHPFLGPSFSSHLVCFFSSSFIFLHFFFLFLFFFADAPFLFLYFSSFLSFSFTFFILLSPTLSVSHPLSLHSPLSLSLSLSLSQLIFFFLLSLSFSFTFSPLFLFLTLSLSLSLSLSLLYVFQITLNLSILTSLSPSVAPSLFFARVTLNLSIFIFLFLKPFSLSLSLSLFLSLDERFPSILFQVTLNLSICITLPFSLSLSHSLSPCTFSFHSFARDTLSIYPFLSIFFLLSHFLSTSNNFTRFITFRPTIGTNVINLLFLLLFLLLSTFFDTSIYLSISLSNFPSSCFFLVLFWFLSLSLLCFSLCYYQTFTLSLSLLPSFFLSFFLSFFLSLSIYLSIYLSTFVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AXP1</accession>
    <name>A0A812AXP1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_7442</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000238">
        <property type="protein sequence ID" value="CAE1162834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AXP1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1162834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="226" mass="25855" checksum="E498B3B571D7C806" modified="2021-09-29" version="1">MLILFPFRSHFLPPLSLSLTYSLSFLFLSLSPAFSLSIYLSIYLSIYLSQSDYTICLSISPPQSVYIIYLSIYLSIYLSIYLSIYLSKSVYTICSYYQSIHRLKLLILYLYLNALSVYLSKSVHIYLSIYLSIYLFEYGLANEVSFSPPPSLSHSLSLFLSLSLVSISAKRLASLEISTILASRFRVKNLSIYLSIYLSIYLSISTHSLSLPSLSLSIYIYIYIYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AY93</accession>
    <name>A0A812AY93_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_7978</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000258">
        <property type="protein sequence ID" value="CAE1164302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AY93"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1164302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="218" mass="26266" checksum="7D57084D7D397630" modified="2021-09-29" version="1">MYPSIFFSHPIYYEIFLSQSILFLSLFIGLSFFSVFFFFCFLYFLSFSFLPRHQFHAFFFPQLNIFLKVFSHVHFNFLYTFLYSLLFVSLFRSPSLHTLSLIYSHSASFSQFFFYSLSLFIPLSFSLSISNYSLSPVLFVSIPFFFISHVLFFLSFLISLPVFLSISIIISRKIIFIFLFRIYLSIYLSIYLSIYLSIYLSISYIYIYIYIYIYIYIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AYI6</accession>
    <name>A0A812AYI6_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase A2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SPHA_7124</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000229">
        <property type="protein sequence ID" value="CAE1162009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AYI6"/>
    <dbReference type="OrthoDB" id="6276451at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06094">
        <property type="entry name" value="RP_Saci_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000130">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon opus-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001995">
        <property type="entry name" value="Peptidase_A2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034132">
        <property type="entry name" value="RP_Saci-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50175">
        <property type="entry name" value="ASP_PROT_RETROV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A2" evidence="3">
        <location>
            <begin position="148"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="59"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAE1162009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="310" mass="34848" checksum="9DEC9C7E48235156" modified="2021-09-29" version="1">MSENTSIDQLADAADRIFSQLDNQTTPVHSAEATRDHSSLEKTVEDLQRQVKDLTLAIESHGRSRFPSRRRFRSRPRSSSRNKDATPTMCYYHRRFGSAAHYCTKPCSYTAVAGKQNRQRVKATNLAGKAFSPKLSRLFYVTDTRNNLRFLVDTGAAISVLPVRDKARKQPFQLRLQAANGSSINTYGTKSLTLNIGMRRDFTWNFTVADVQMPILGADFLAHYDLAVRMNNHSLTDNLTRLCVLGTYSKLTTTGITVATCHNKEYLDLLNQYQDLLRPAGSIDSTKHQTQHFIKTTGQPVFFPSSSSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AYY7</accession>
    <name>A0A812AYY7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_7789</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000253">
        <property type="protein sequence ID" value="CAE1163787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AYY7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1163787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="225" mass="27979" checksum="3C20E8C42BEC24EC" modified="2021-09-29" version="1">MLHQIYCYCYHLIYSFIIFSSILRRQQSQYLIFLFLSFFFFSFSLYFSFRFLFYLTFFPNSSFFIFPVSLFYFLSLFFYLYFFFLFNTFSFLSFFLSFFLSFFLSFIDSCFLAIIFLFLHFFFFIFFLFLFLPVFFPFFLVFLFFPHFHSYISSFLFIFFFVISIFFYSFLFHSITHFFYSFLPSFHLSSFLSFSLLISFFFSFIPLPSIFPYICTYLYLCASIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AZ70</accession>
    <name>A0A812AZ70_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4817 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_7122</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000229">
        <property type="protein sequence ID" value="CAE1162005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AZ70"/>
    <dbReference type="OrthoDB" id="9979538at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1162005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="204" mass="22842" checksum="8F092B4E43106164" modified="2021-09-29" version="1">MEWTKLERAFAVEAFFFSSGRSIVATQRAFRRHFNIPPPPWSCSWPAVDCFMGKQLQGRICWAFAFQKDVFFGELEAGICPNGGQKKRFHDYLKQPRNGSDPLAISLRRRSGALRVGETRRAREKATPATSSLCQFCTGNFSLPPVSESLSFADRAAISFASPEKTDGDGRTASSSFVIIYLSIYLSIYLSIYLCLIVNIISSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AZW3</accession>
    <name>A0A812AZW3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_8113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000262">
        <property type="protein sequence ID" value="CAE1164625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AZW3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1164625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="283" mass="33218" checksum="A9872C53B0B55242" modified="2021-09-29" version="1">MFLPSLLPFILFFSFLSFFLSVTVTPGPVSDPLLRANVCSYLSLFISIYLSIYLSIYLFLSLSLYIYIYIYIYLSVYIYLSQSVHIYRKIYLSIYFSLFISISFCLYLSIYLSIYLSLYLSIYLSVCLSVCLSLLISIFLSIYQSIHIYLSFCLSISLFISIYLSILSKTVHISLYLSISLSLSLYIYIYIYIYIYFTLFISIYLSLFISIYFSLFISILFCLYLSIYLSIYLYIYLSIYLSIYLSVLYSSYYYTLSFFLCLSVCLSLSLFLAHLLSLLSLSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B0J7</accession>
    <name>A0A812B0J7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_7164</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000231">
        <property type="protein sequence ID" value="CAE1162153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B0J7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="88"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1162153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="262" mass="30493" checksum="D51E0C0CB842BB35" modified="2021-09-29" version="1">MRELIFNELITSTAILNEACSTPHTTLHFLICLRLLINLSLFSLSFYLPLSLVCFSLSLSLSLSRFFLSFSFSLSFLSLSIFSLSFSLSFVSLSLSLSRFFLSLFLSFSFSPSFSLSLSFLSLSLSLSRFFLSFFLSFFLSFFSFFLSLFLFFLSFFLSLFIYLFFSFSLSRLFLSLSLSLIASLLSFSLPFSLSLSLLFFLFFSFNFSSLLSSFSFFLTFFFLSFFRFHIIFFFLHFFFVRFSSFSFCFLFISFCHSINLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B2S3</accession>
    <name>A0A812B2S3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ZDHHC</fullName>
            <ecNumber evidence="2">2.3.1.225</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_10037</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
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            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
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            <taxon>Acanthosepion</taxon>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="2"/>
    <dbReference type="EMBL" id="CAHIKZ030000322">
        <property type="protein sequence ID" value="CAE1168418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B2S3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="128"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="205"/>
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        <location>
            <begin position="217"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="323"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="370"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="404"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="435"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="490"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="520"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="561"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1168418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="621" mass="75605" checksum="F228E71EB29CCFB8" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B5D6</accession>
    <name>A0A812B5D6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_10395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000335">
        <property type="protein sequence ID" value="CAE1169057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B5D6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1169057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="199" mass="23401" checksum="DD084B95EC0AA9F7" modified="2021-09-29" version="1">MDSTPGENFTYFFFFFLHFLSFLFSLFEVHYLVLFYLFLPVFCLFYAFIHLFFLSLSLSLSLSLSLSLSLPFLFLRFFFLFFFLDLSTYSIFLCVTFRSLIFLKISTVLKYRFPIAASRFLSFSLSLFLSLSLSLSLLSLSPPSLSLSCFLSSFFSHYCFTNLNTFFLCFTLHPYFSLGFFLHFNFSLILFSSSVYLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B5T6</accession>
    <name>A0A812B5T6_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_11546</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000381">
        <property type="protein sequence ID" value="CAE1171398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B5T6"/>
    <dbReference type="OrthoDB" id="6740508at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1171398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="206" mass="22584" checksum="952BA2D9E4ABCA3D" modified="2021-09-29" version="1">MKQAAWLSVEVVLAEIFADNESDRFSENSDSDNPDYVWEDGNGCESETDGNISDDLSDHGDADMNVHHGQGDGQPICIGAAGVGNNAMPAAPDGPVAMPAAPAVHRPGPADPVYLDNYYNSVALAKFFLEDERKVHVCGTLQLNRGAPRDQQQEADHLQRRQNLVRPRLPPLTIIPLTLKMKGKLLKLWYVQGHLKLILPIAWLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B5V2</accession>
    <name>A0A812B5V2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_10783</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000352">
        <property type="protein sequence ID" value="CAE1169829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="302"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="340"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="384"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="415"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="445"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="480"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="518"/>
            <end position="538"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="545"/>
            <end position="565"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="596"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="608"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="643"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="674"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="701"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="791"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="817"/>
            <end position="839"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="851"/>
            <end position="875"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="881"/>
            <end position="900"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="907"/>
            <end position="927"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="933"/>
            <end position="954"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1000"/>
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        <location>
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        <location>
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        <location>
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        <location>
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        <location>
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        </location>
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        <location>
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        </location>
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        <location>
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        <location>
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        <location>
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            <end position="1304"/>
        </location>
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        <location>
            <begin position="1310"/>
            <end position="1335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1342"/>
            <end position="1358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1169829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1359" mass="160083" checksum="45F221361EC191C3" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B5Z5</accession>
    <name>A0A812B5Z5_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Medium-chain acyl-CoA ligase ACSF2, mitochondrial</fullName>
            <ecNumber evidence="4">6.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SPHA_11666</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Farmed</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Acyl-CoA synthases catalyze the initial reaction in fatty acid metabolism, by forming a thioester with CoA. Has some preference toward medium-chain substrates. Plays a role in adipocyte differentiation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a medium-chain fatty acid + ATP + CoA = a medium-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:48340"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:59558"/>
            <dbReference type="ChEBI" id="CHEBI:90546"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>octanoate + ATP + CoA = octanoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:33631"/>
            <dbReference type="ChEBI" id="CHEBI:25646"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57386"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.2" evidence="4"/>
    <dbReference type="EMBL" id="CAHIKZ030000386">
        <property type="protein sequence ID" value="CAE1171611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B5Z5"/>
    <dbReference type="OrthoDB" id="1700726at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF5">
        <property type="entry name" value="MEDIUM-CHAIN ACYL-COA LIGASE ACSF2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="8">
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            <begin position="129"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAE1171611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="398" mass="44935" checksum="3BCCC7578ED90D7B" modified="2021-09-29" version="1">MVLGVVCNEEMSCLLTSFLGAYGSRLLIIRSVPKSKCHEFKPGKKRPRTTSENMIPNVIFSRIISCRGYKEIQYSLNKQALLYQLGKKQWTFTPNNRLYSSHVNDCHRISYRHAASSVSLKGVTIGNLFQEQVEKIPDKEALVFYSDKIRKTFSQFLEECDQFAAGLHCLGIKKGDRLGIWGPNTYEWVLTEFAAFRSGIILVSVNPAYKKEELKYALNKTDMKAIVIAEALPKQDFYDILFQLAPELETAPPGGLNAQNVPHLKTVIMMGQTNKPGSFLFNDVIQAGTTKDRQYILDIQKKLQFDEPINIQFTSGTTGSSKGATLSHHNIVNNSYIAGLRLAYDKMETRICVPVPLFHCFGSVLGSPHDANSWSNLYLSIKSIQYKESFSLLYKDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B958</accession>
    <name>A0A812B958_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_13121</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000436">
        <property type="protein sequence ID" value="CAE1174453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B958"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1174453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="301" mass="35338" checksum="B5276A0E477A98F7" modified="2021-09-29" version="1">MNKYLSHIFSLSPSIPLSLPLSLLSLSLPLSFCYLTISIYLTLFISIYLCSYLSIYLSHFIHIYLSIYLSIYLSIYLSIYLTLFISIYLCSHLSIYLSHSIHIYLSIYLSISLYSYLFIYLSIYLKLFIFYLSIYLSIYLSIYLSIYLSLNVSLSLSIYLFICLSVSFHIFLYHPSIYLSIYLSIYKAVHYLSIYLSIYSFIYLSIYLSIYLSIYLKYLSFSSFFLSMLIFFSLYLPYFSPLHSMFFTFLPSSHSSQFFPLFISFSLATLPLFSFLLSSLVFSPLHFPFPLTTFSPTTVHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B9Y4</accession>
    <name>A0A812B9Y4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amyloid-beta A4 protein-binding family A member 1,Protein lin-10,Amyloid-beta A4 protein-binding family A member 2,Amyloid-beta A4 protein-binding family A member 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SPHA_12843</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000430">
        <property type="protein sequence ID" value="CAE1173908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B9Y4"/>
    <dbReference type="OrthoDB" id="5987010at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043197">
        <property type="term" value="C:dendritic spine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06720">
        <property type="entry name" value="PDZ1_APBA1_3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06793">
        <property type="entry name" value="PDZ2_APBA1_3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01208">
        <property type="entry name" value="PTB_X11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000007">
        <property type="entry name" value="Amyloid beta A4 protein-binding family A member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000017">
        <property type="entry name" value="Amyloid beta A4 protein-binding family A member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051230">
        <property type="entry name" value="APP-Binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12345">
        <property type="entry name" value="SYNTENIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12345:SF16">
        <property type="entry name" value="X11L, ISOFORM F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00640">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00462">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01179">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PID" evidence="5">
        <location>
            <begin position="2"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="159"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="250"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAE1173908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="340" mass="37382" checksum="E1DF7C262C2F4785" modified="2021-09-29" version="1">MRMMQAQEAVGRIKAPEGENQPSTEVDLFVSTEKIMVLNTDLQEIMMDHSLRTISYIADIGDILVIMARRRLLSSPGDESLRRKKQAKILCHVFESDEAQLIAQSIGQAFQVAYMEFLKANGIDDPGIIKEMDYQDVLNQQEIMGEELNLFTNKDFHREVIVPKLKGEPIGIVIVESGWGSMVPTVVLANMAPSGPAARCGGLNIGDQIISINGVSMVGLPLSTCQTYIKGARQQTVVKLTVVPCPPVVEVLIKRPDVKYQLGFSVQNGVICSLLRGGIAERGGVRVGHRIIEINNQSVVAVQHEKIVALLANSVGEIHMKTMPTSIFRLLTGQETPHYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BH34</accession>
    <name>A0A812BH34_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_15975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000558">
        <property type="protein sequence ID" value="CAE1226332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BH34"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="335"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="401"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="424"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1226332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="449" mass="53236" checksum="C40BA7DA36630922" modified="2021-09-29" version="1">MSFSFLCLFLYLFHSCLHRESILFLFLLNSHLFFFIIRLSMSFYFLCLFLHSFHSCLHRHQLLSFFFLLKHTFLFHYSLLLLLCLLLSLLFFIPSFHSCHHRQQIPFLFRSHLSLGTLTFFCFLSLFFIVILSHDLSIYLSIYLSIYLSIYLSIYLSIYVIYLPIYLSRFTDIHLIFYLSIYLSIYLSIYLSIYLSIYLFHSLDIHHISSMFTDIHLSIYLSIYLSIYLSIYVHRYPSYFLLSIYLSIYLSIYLSIYLRVFTDTHHSFLYLSALEISSSFLLSIYLSIYLSIYLSIYLSIYTSLSYLCIYVSIYLYQFVHIYLYSTLGLMNFRIAYLSIYLSIYLSIYLSIYLSFYLSFFLSSYLTHSVYIYLMCISTSLSLSLSLSFVTVPPLVASHFSALYQLLPPPLVASVSFSRSFSRSLSFNIFLSLLITPAFYFLVKAEKFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BK12</accession>
    <name>A0A812BK12_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_16992</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000602">
        <property type="protein sequence ID" value="CAE1228766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BK12"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1228766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="213" mass="25140" checksum="6E04B4A066FF3420" modified="2021-09-29" version="1">MILSHSNPYLIPILPTYLPTYLSIYLSIYLSIYLFISIYLSINPSIYLPILLFISIHFYLSICLTILSIYSFLSIYSFLSISLFIYSHIYLSIYLSIYLSIYLSVSPFLSIYLFISIYLTIYFDLSINLAISIYLSVSPFLSIYLFISIYLFISIYLTIYFDLSINIAISIYLSIYLSIYLSHHFYLSIYLFISIYLFISIYLSIYYNIEIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BPB6</accession>
    <name>A0A812BPB6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_19308</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000700">
        <property type="protein sequence ID" value="CAE1234146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BPB6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1234146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="219" mass="25825" checksum="6D1019C5F3BFC302" modified="2021-09-29" version="1">MKHTIKTLIIHSLFLSFFFWIMSDQYLSIYLSIYLSIYLSIYLIQSNFLRHLIFLSIYLSIYLSIYLSIYLSHSFHCLSIYLSLFISIYLASENLSNFIHYLIFLSIYLSIYLSIYLSIYLSKYLSIYSTSIYLSIYLIRFSISKLVHYLSIYLSIYLSISFISLSIYLNLILSIYLSNTIQISIYLSIYLSIYLSIYNLTSTNTPEMNGDPTKVLPSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BTF6</accession>
    <name>A0A812BTF6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_24989</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000945">
        <property type="protein sequence ID" value="CAE1246085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BTF6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033046946" evidence="2">
        <location>
            <begin position="25"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="296"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="335"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="398"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="522"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="574"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="598"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="623"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="652"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="685"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="735"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="761"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="788"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="857"/>
            <end position="878"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1246085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="879" mass="101600" checksum="78D16B838AA26D24" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BUC1</accession>
    <name>A0A812BUC1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_25476</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000966">
        <property type="protein sequence ID" value="CAE1247154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BUC1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="179"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="253"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="333"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="395"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="429"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="462"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="490"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1247154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="510" mass="61954" checksum="78D8CE0CDFCD3AFF" modified="2021-09-29" version="1">MIFLSFFLSFFLSFFLSFFLSFLFFLSFFLSFFLSFFLSFFLLLSFLFYAFIFLIIVNFFLSFFLSFFLSFFLSFFLLLSPSPPPTPFIFLLLLLLLLLLLLLLLHFFFLHYYLSFFFFKILAHQHHHHHHHHHHHHHHLYSLSPPPPPFIFLLLLLLSIYSSSSFYPFYIYFYIPHFLWFFFFFFSIIFFFFFFFFFFFFFFFFFFFFFFFSPYSSYYYLSFFFFKILTHHHHHHHHHHHHLYSPSAPPPPFIFLLILLLHVCICRPSYSSSSSSSSSSSSSSSSSSSSSSSSPYSSYYYFWYFFFKILAHHHHHHHHHHHLYIHSPPPSPFIFLLLLLLLLLLLLLVLFFFFIFSFFFFSLIFMPSPFFNFFSSFQLFIRLPHHPSYSPPSSLFSHLLACPSISVVFSFKFFSFIVIITLYPPLSSFLYPFSLLLFFLIHLSISSFLFIFFYLHHHHHPINITIIIMLTFLFLFFSFFFFFLQVYFSLSSFCAFNFSSFLLLSSLSFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BXS3</accession>
    <name>A0A812BXS3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_23659</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000876">
        <property type="protein sequence ID" value="CAE1243174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BXS3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1243174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="193" mass="22654" checksum="AE0E50C1B5292BE8" modified="2021-09-29" version="1">MLNLHPPLFLSPSLFLVVSFLLFFFIFLPFPFKPFSSFIFSLTSSSSFSSLCFLNSISLFPYPFFLPLNQWSPNSVAQLMGVAEENSREKICLGTTALNHYSFFSFLFSFFSITLFSLLLFTRLFLFLCLFIPFFLFFLFLLVFFPTSFYFPLFFLLFSSINFFLPYILFPFILSSYSLSISLFLCFPLYFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BZ54</accession>
    <name>A0A812BZ54_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SPHA_26798</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001024">
        <property type="protein sequence ID" value="CAE1249784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BZ54"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51225">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="265"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="321"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="348"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="377"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="405"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="440"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="470"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="499"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="526"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="602"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="639"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="7">
        <location>
            <begin position="198"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAE1249784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="684" mass="82361" checksum="4ADC9C8D4E62DA80" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BZE4</accession>
    <name>A0A812BZE4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_29697</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001188">
        <property type="protein sequence ID" value="CAE1255605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BZE4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="301"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1255605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="320" mass="37904" checksum="21D72D0F8EE2DD08" modified="2021-09-29" version="1">MTFHSFLLVIRVISLCPYIYRFTSVSWHFFRFVHLSRFLFRFATLFRSLFLFCSSFLSLSSYFTSLSLSFSPFSTNLSFFLVLYMFLAHFPVFYISLSSFPVLLPVPCSLSRFVPVSRSLFRFVCFFPLFSFVLVSRSLSRFVPVSRSLSRFVCFSFLFRFVPVFRTPFPFCTCLSLSFPLCVFLSPFQFCTCLSLSFSVLYLSRSLFRFVCFSFLFRFVPVFRTPFPFCTCLSFSFPFCVFLSSFPSLPLFFLSFFFFSWPFLLSLIFFHSFLSYSLVTISFVVSVLFTEPSFLIKKKCFLFLFFYLWLLLLPLCCKFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C0P7</accession>
    <name>A0A812C0P7_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA-directed RNA polymerase III subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SPHA_26180</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Farmed</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the RNA polymerase III (Pol III) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the eukaryotic RPC7 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001001">
        <property type="protein sequence ID" value="CAE1248455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C0P7"/>
    <dbReference type="OrthoDB" id="5377312at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024661">
        <property type="entry name" value="RNA_pol_III_Rpc31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15367">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15367:SF2">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11705">
        <property type="entry name" value="RNA_pol_3_Rpc31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000777">
        <property type="entry name" value="RNA_polIII_C31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="124"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="152"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAE1248455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="204" mass="23729" checksum="2CD61EFAD4806EF8" modified="2021-09-29" version="1">MAGRGRGGRGLSFNIDALGFGRGDALPQAINQPPPLFPPLELKAVPLLQGEEYEYMLALKQEFRGTIHESPFYIKVTEKKKDIHRYSDKYQTSLENNNSWEPDWDSLPNELKWNRKKLKKVRFTPRPNLPSKAEAAEVLKTLESLEKKDNQTEENEDEEKEAEEEEEVFEEEDEEDNDYNLNYFDNGEDYGDEDDDDMDEGPIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C1L2</accession>
    <name>A0A812C1L2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_28142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001110">
        <property type="protein sequence ID" value="CAE1252833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C1L2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="325"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="380"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1252833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="399" mass="44259" checksum="9AF83B5A3B4FDC71" modified="2021-09-29" version="1">MTNWELNVLTSTPSLSLFPSPSITPYSLLTLSPPPPPFFLLLCSSSLLSPSPLFHSLSLFSSVSLYLFPSLSLSTSSHFFLSSHLSPPSLLSPSISFFPSLSSFISPSFSIPLSPTSLLSPSPLFPSLTFYVLSFSSLLSPSSLRPPSSLLSPPPVSFISYSLLFTSFLLSPTSPIPFSLLISSSSILSPSSVLPPPPLSPLFLPPRLSNSLPLLLFSLLLSLSLSLCLSLFSMLSTSFFFVSHFSYSLLFLSFPLVSLPLSVRLLALLSFYTNSIFLSIYHDLLFFISPLSQFFFLVIIVFLTLSYSLPLTLKSLPFHSSLLHSYYILLFFISFLLIFPFSFCHFRYHFINHSITLLSLFLSISLSLSLSLSFSLSLSHTQLSFFLLLYLINSYLFIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C1V3</accession>
    <name>A0A812C1V3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_26955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001032">
        <property type="protein sequence ID" value="CAE1250099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C1V3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1250099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="316" mass="37708" checksum="A154FBB24BE30D58" modified="2021-09-29" version="1">MLSFLIFFFNNSLSISVFFLHLFSLPHFAIFLLLSFFSFFLSFFLSFFLVFFAFSVFHFLSFLLSFFLFSFLSFFLSFFLFNKLFRSYFLIFSFFFLSLNHLFLFPISFFLSFFAFSMFSTLFLSFFLSFFLSFFLSFFLSRSLCFSMFSTFFLSFFLSFFLSFFLSFYSFSVFHFLSFFLSFFLSFFLTFFISNILSSRSFSLTFFFHFETFSFFFPVSFSYSFTLPFSHALFLLLRFPLSHYSSCLSLFLLFLCFSSFHFPPLSLSLSSFPLPLSLVSKCPLSLPYTPFHSPIRSDSLFFTFRCSARPLNSFDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C2D0</accession>
    <name>A0A812C2D0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="15">PCDHGB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SPHA_28562</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001116">
        <property type="protein sequence ID" value="CAE1253701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C2D0"/>
    <dbReference type="OrthoDB" id="6252479at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000020">
        <property type="entry name" value="Dachsous cadherin-related 1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000004">
        <property type="entry name" value="Protocadherin 1 gamma 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000002">
        <property type="entry name" value="Protocadherin alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000134">
        <property type="entry name" value="protocadherin Fat 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050174">
        <property type="entry name" value="Protocadherin/Cadherin-CA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028:SF146">
        <property type="entry name" value="CADHERIN 96CB, ISOFORM D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028">
        <property type="entry name" value="CADHERIN-87A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 11" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 13" id="KW-0732">Signal</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032914911" evidence="13">
        <location>
            <begin position="19"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="690"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="25"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="134"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="246"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="360"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="464"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="590"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAE1253701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="818" mass="91571" checksum="370744491133D398" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C3V5</accession>
    <name>A0A812C3V5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_31897</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001324">
        <property type="protein sequence ID" value="CAE1259976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C3V5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1259976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="400" mass="47783" checksum="17014A436731264F" modified="2021-09-29" version="1">MSPEETKGDEASAARNPECNHSFPVAYLLPCLFLPVFALHRCETALASAMDNVYIYLSIYLSIYLSIYLSIYIYIYIYISVYLYLSNYYRILHYLSQSVTVYLTFYLSMYLILLPSIYLSIYLSIYLSIYLCISYCCYLSIYVFHTVAIYLSIYLYIYLSIYLSIYIYIYIYIYIYIYIYQFLISIYLSIYLSIYLSIYINEIIQRQISIYLSIYLSIYRYIFLWCLSIYLLSIYLSIYLSIYLSIYLSIVIWSYSICLLIYRLSASFSVVVHIYLSIYLSIYLSIYLSIYLSIYNCHCLSAWLIIVLSPSLSLCLSIYLSIYIYLLSIYLSIYRYMMSISIYLSIYLSIYLSIYNYVHIYLSIYLSIYLSIYLSIYLSITLDSYRCRSTYLPIYLSIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CAN8</accession>
    <name>A0A812CAN8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_32545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001358">
        <property type="protein sequence ID" value="CAE1261102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CAN8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1261102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="150" mass="17693" checksum="84EF63B9D29B92DE" modified="2021-09-29" version="1">MFSQILASFVFSLSISHLLYLSIYLSIYLSIYLSIYIYIYIYIYIYANSRFVSIYLSIYILSIYLSIYLSIYLSIYLTTEEYSFFNDMFSKILGSFVFPSHTLTRSIYLSIYLSIYLSIYLSIYLSISTFLSLYPLTLSLDLSIYLSIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CBX6</accession>
    <name>A0A812CBX6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_33084</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001384">
        <property type="protein sequence ID" value="CAE1262200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CBX6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134:SF22">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134">
        <property type="entry name" value="OS08G0543275 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="196"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="396"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1262200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="474" mass="53120" checksum="B5F5A1D0C09C0381" modified="2021-09-29" version="1">MLFHKLLSCYIYFLFLSIYLSIYLSLFLSIYLSMFLSILVCSYLSMFLSISLSLFLSIYLSMFLSIYLSLLSIYLSESVLIYLSISVCSYLSIYLSIYLSLFLSIYLSISVCSYLSIYLSQSVLIYLSIYLSLFLSIYLCSYLSILVCSYLSIYLCSYLSIYLFCSYLSIYLCSYLSIYLSIYVLIYLSIYPSESVLIYLSIYVLIYLSIYLSIYVLIYLSIYCSESVLIYLSIYLSIYRSESVLIYLSIYLSQSVLIYLSYSYLSIYLSIYLSIYLSIYLSINLAICIPPAASSTPTAFSSLLQPSAHSSSFQHSCSFQLSPAASSTPAAFSSLLQLPALLQPPAHSNSFQRPPALSCSFQHSCSLQLTPAASSTPAASSTPAASSSLQQLPALLQPPAHPCGAQTDNPRPNPVPTDVQRPLSSGHRSRTNDLCRLTIHRSQIKTRFPSSTTDHLRLSSFFAIAISLPLCPLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CCF3</accession>
    <name>A0A812CCF3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_33483</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001402">
        <property type="protein sequence ID" value="CAE1262931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CCF3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="290"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="314"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="344"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1262931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="413" mass="46821" checksum="3F29370CA9158A25" modified="2021-09-29" version="1">MASRVFRNFSSRLFPTVLFLSFISPHPHTKFVYYHPVFPSGDYSLLFSIILFFSLSFYTFSSLHCSLSLSLSLSLSLSLSLTYTFSFSFSVFLPFSPLSFSRFLSLFLPTFLSPSPSLSFSNIYSIPLTFSLTHTQSPFPVFLPLFSSLLLRCSLTHCHSLFLFLSSFSFSHLFLSFRLFSPFLSHSLSLSLSLSLTLSRTHTHRHIESRRRFKDLFPILPSEASIHSMPLAVHPTFLSIPLPLPPLSVPLISLSLSLSNSLSIYISHFLSFYPSPYSSLNFSLSVPPSLFLSLSFSLIVSLSIQFSLCPSPSLYFFLFHSYLSCFSLFNFSSSSSSSSSSSSSSYNLLHFFFIFSFCFSDLSFSLTLTLAIIAFSFFFFLSFVIIKSFHISSLFLRFLLDFLLEFSTPFSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CCM6</accession>
    <name>A0A812CCM6_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_36901</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001626">
        <property type="protein sequence ID" value="CAE1270070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CCM6"/>
    <dbReference type="OrthoDB" id="6123744at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="240"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1270070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="451" mass="51525" checksum="0D34DF6729EF35BE" modified="2021-09-29" version="1">MTVVRPTSSVLDSRACRVQIRAVRMDRIIHLSAHASALKSATVKVAHAHLGVTRRRHRDWITWESLQLVKKTSVAGLTGATNFRDLRRRATHSNRADRNAHWHVFTEETERAVACGDSRKLYQMVRRASRGIAEVSETLNRWKEHFNELLNHPTPATEVAVEATDEYDCNSTPATVNEVRDILRHLHNNKAPGEDGIPAEVYKAVPDVFASWEHYVFNAVWLSESYPADWFDAILLPFFKKGDRRLCANYRGISLIDVVDKVFAMLLLRRFHRIRDVRTRPSQAGFHPGRGCVDQILSLRRTLEQRWAYQQPTVLCFVDFAAALDTVNRGALWRIMEADGMPAKLLRLIRCYYRSMRARARAYGEESETFEVKTGVRQGCALSSTLFNYTIDYILGKALRDYAGVAFGSGEQNKDLFVVFAVVKGFRYCISNCSLQIFVRISCSRKNAPLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CE93</accession>
    <name>A0A812CE93_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_33243</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001391">
        <property type="protein sequence ID" value="CAE1262478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CE93"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1262478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="176" mass="19929" checksum="CA72292913976B71" modified="2021-09-29" version="1">MWLMCELDILSLSLSLSLCVSFSFSLSLLSLSLSPSLSLLISLSLSLSLSLSLSLSPLLSFLSFCYSNSYYIPFYISCHSLYPPLSLSLSRFVFSYLSIDLSIYLYRFVSIYLSIYLSIYLSIYLSISIALYLDIYLCITLARFLYFSLFPSPLLLFSLSLSLSLSFFPFLLSFSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CGV1</accession>
    <name>A0A812CGV1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WBP2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_33362</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001395">
        <property type="protein sequence ID" value="CAE1262705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CGV1"/>
    <dbReference type="OrthoDB" id="1259151at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13214">
        <property type="entry name" value="PH-GRAM_WBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004182">
        <property type="entry name" value="GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044852">
        <property type="entry name" value="WBP2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31606">
        <property type="entry name" value="WW DOMAIN BINDING PROTEIN 2, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31606:SF1">
        <property type="entry name" value="WW DOMAIN BINDING PROTEIN 2, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02893">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GRAM" evidence="2">
        <location>
            <begin position="32"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1262705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="243" mass="26929" checksum="65E15B240A8AF24A" modified="2021-09-29" version="1">MSLNSSHYNNGVLVYAGERILIYCDGVQMSFEGGNLPTGNKKGRIYLTSHRVVFISNNQNDNLQSFSMPFFTMKEVELEQPIFGANYIKGVVFAEQGGKWCGHAKFKMSFNHGGAIEFGQAMLQAGKIVSRYQMPQPPPYTPPQGPYYQPPPPAYSAPRYDWVPYQTFPNAPPASEVFMAEAPPPYPGIDPSLTPYPNNPPQDAKAREAAASAYYNPANPHLLYMPSPNEPPPPYTEATKKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CHU6</accession>
    <name>A0A812CHU6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_35127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001510">
        <property type="protein sequence ID" value="CAE1266347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CHU6"/>
    <dbReference type="OrthoDB" id="1421090at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1266347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="240" mass="27979" checksum="D4BE03FE27F1632D" modified="2021-09-29" version="1">MRKPGSLPRQNESENRLLVTASAIVLQGYRFLHCFFVISIICYSLSIYLSIRFCSYLSIWLASRFCPYLSIYLSISLSLSLSLSLSLYLSIYLSMLFYSVHIYLSIYLSIYLSDSVHIYLASYQILPISIYLSIYLFYSVHIYLVIRFCTYLSIYLSNSVLIYLSLSLYLSIYLSLYLSILFCSYLSIRFCSYLSIYLSNSVRIYLSNSVRIYLSDSTNIYLSDHVSIYLSIYLNLFLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CJR8</accession>
    <name>A0A812CJR8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ankyrin repeat and fibronectin type-III domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_35400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001523">
        <property type="protein sequence ID" value="CAE1266954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CJR8"/>
    <dbReference type="OrthoDB" id="2428204at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061172">
        <property type="term" value="P:regulation of establishment of bipolar cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039269">
        <property type="entry name" value="ANKFN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21437">
        <property type="entry name" value="WIDE AWAKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21437:SF1">
        <property type="entry name" value="WIDE AWAKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="351"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="457"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1266954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1031" mass="116217" checksum="68E269D99299FF22" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CK95</accession>
    <name>A0A812CK95_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_35245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001513">
        <property type="protein sequence ID" value="CAE1266586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CK95"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1266586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="252" mass="31051" checksum="EC6C9312FFF3C911" modified="2021-09-29" version="1">MFLLSLYFFLCFCVIDRLFRFLSFFLSFFLIPLPSPLFLIYFLFFLFAPASVPLSFFLSFFLSFFLSFFLIPLPSPLFLIYFLFFLFTPFRSSFFLSFFLSFFLSFFLSFFLSYSITFSFISYLFPLFPVRPRFRSSFFLFFLSFFSFFLSFFLFHYLLLYFLFISSFPVVRPLPFFFTFFLIYFLFLFFLSFFFLFLSFFLIPLPSPLFLIYFLFSCSPPFFFLFLFSFFFFLSFHFLLYFYLFSFSSHFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CLU2</accession>
    <name>A0A812CLU2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">TADA2B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SPHA_36146</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001576">
        <property type="protein sequence ID" value="CAE1268584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CLU2"/>
    <dbReference type="OrthoDB" id="270417at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070461">
        <property type="term" value="C:SAGA-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02335">
        <property type="entry name" value="ZZ_ADA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041983">
        <property type="entry name" value="ADA2-like_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055141">
        <property type="entry name" value="TADA2A_B-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12374:SF63">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 2-BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12374">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTOR 2 ADA2 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22941">
        <property type="entry name" value="TADA2A-like_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25299">
        <property type="entry name" value="ZZ_ADA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SANT"/>
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    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
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    <feature type="domain" description="ZZ-type" evidence="8">
        <location>
            <begin position="147"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="9">
        <location>
            <begin position="209"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="10">
        <location>
            <begin position="213"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="7">
        <location>
            <begin position="213"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="276"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="401"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="482"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="287"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="482"/>
            <end position="500"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="502"/>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="533"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
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    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
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    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAE1268584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="593" mass="67038" checksum="1157925E78B69FBC" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CSF1</accession>
    <name>A0A812CSF1_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">10-formyltetrahydrofolate dehydrogenase</fullName>
            <ecNumber evidence="9">1.5.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">SPHA_43967</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Farmed</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(6R)-10-formyltetrahydrofolate + NADP(+) + H2O = (6S)-5,6,7,8-tetrahydrofolate + CO2 + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10180"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
            <dbReference type="EC" id="1.5.1.6"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:10181"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">In the N-terminal section; belongs to the GART family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.6" evidence="9"/>
    <dbReference type="EMBL" id="CAHIKZ030002225">
        <property type="protein sequence ID" value="CAE1283295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CSF1"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016155">
        <property type="term" value="F:formyltetrahydrofolate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009258">
        <property type="term" value="P:10-formyltetrahydrofolate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07140">
        <property type="entry name" value="ALDH_F1L_FTFDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08703">
        <property type="entry name" value="FDH_Hydrolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000002">
        <property type="entry name" value="10-formyltetrahydrofolate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.25.10:FF:000002">
        <property type="entry name" value="10-formyltetrahydrofolate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000050">
        <property type="entry name" value="Aldehyde dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000026">
        <property type="entry name" value="Aldehyde dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000008">
        <property type="entry name" value="Cytosolic 10-formyltetrahydrofolate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.25.10">
        <property type="entry name" value="Formyl transferase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.170">
        <property type="entry name" value="Formyl transferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="10_FTHF_DH"/>
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    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
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        <property type="entry name" value="Ald_DH/histidinol_DH"/>
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        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
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        <property type="entry name" value="Ald_DH_CS_GLU"/>
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        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
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        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005793">
        <property type="entry name" value="Formyl_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037022">
        <property type="entry name" value="Formyl_trans_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
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        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011034">
        <property type="entry name" value="Formyl_transferase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001555">
        <property type="entry name" value="GART_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02911">
        <property type="entry name" value="Formyl_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036489">
        <property type="entry name" value="10-FTHFDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50486">
        <property type="entry name" value="FMT C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="Formyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00373">
        <property type="entry name" value="GART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 12" id="KW-0521">NADP</keyword>
    <keyword evidence="5 9" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="7 9 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="16">
        <location>
            <begin position="343"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <feature type="active site" evidence="14">
        <location>
            <position position="696"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="696"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="730"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="113"/>
            <end position="115"/>
        </location>
        <ligand>
            <name>(6R)-10-formyltetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>(6R)-10-formyltetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="620"/>
            <end position="623"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="653"/>
            <end position="658"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="673"/>
            <end position="674"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="780"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="827"/>
            <end position="829"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="site" description="Essential for catalytic activity" evidence="13">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR036489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR036489-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR036489-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR036489-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR036489-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAE1283295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="925" mass="102474" checksum="3BEFA3B94E07A80B" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CSN1</accession>
    <name>A0A812CSN1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_39289</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001813">
        <property type="protein sequence ID" value="CAE1275094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CSN1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1275094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="258" mass="27599" checksum="97BA4107D53BF91B" modified="2021-09-29" version="1">MVPIFFLARSLSLSLSLFLPLPLSFSLCLSCSLSLSFSPSLSFSASFACFLSLLLPLPLPLSLPHLITFSLSLCLSYSLSLSFSPLFHSLSLYLSCSLSLSPSLSFSASFACFLSLFLSLPLSLCLSSSISLSFSPSLSLSASLARFLSLSLPLLLAFSLSPSLSFSASFACFLSLLRTLPLSASLNRFLSLSSFSLSLCPSCSLSLSFSPSLSLCLSCFLFLFLSLPLLLAFSLSLAHSPSPPLSLVRFFFPSRSLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CUW0</accession>
    <name>A0A812CUW0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SPHA_43980</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002225">
        <property type="protein sequence ID" value="CAE1283268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CUW0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030020">
        <property type="term" value="F:extracellular matrix structural constituent conferring tensile strength"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050149">
        <property type="entry name" value="Collagen_superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023:SF845">
        <property type="entry name" value="COLLAGEN ALPHA-1(XXII) CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="424"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="485"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="61"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="120"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="235"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="296"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="173"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="92"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="124"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="256"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="296"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAE1283268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="574" mass="62652" checksum="24A3DCA7869B9EFE" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CXK0</accession>
    <name>A0A812CXK0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_43331</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002168">
        <property type="protein sequence ID" value="CAE1282237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CXK0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="343"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1282237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="372" mass="45905" checksum="8AD0A4118CA08EFD" modified="2021-09-29" version="1">MLSFIFLLPLFLSFIFSSSFFLFLFFFFSFIFLFFLSYFPSFISFFHIFLLFSFVYFFPILIFSFLSYFPSLFLSFIFPSSFLSFIFSFFISLFHIFLLPFFLSYFPSLFLSFIFSFLLSFFHIFLLYFSLSYFPSSFLSFIFSFFISLFHIFSSFLSFIFPSLFLFFLFPSSFLSFIYLFHIFLLSYFASLFHIFHLYFSFIFPSVFLSFLFPSLFIYFIFSFFMSFIFSFFISLFHISFFFSFSYFPSLFLSFIFSLFHSFFFSFLFHSFFLSLFLFYFLSLEFYLFFPLHFSLSYIFFISVFSFHIFFFISFILIYFILFTFLFSLFHKTNKVGKKINRFLIFFLYNSFFFLFFFILSVAHFHLTFYYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D0T1</accession>
    <name>A0A812D0T1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_44427</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002269">
        <property type="protein sequence ID" value="CAE1284001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D0T1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1284001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="253" mass="31397" checksum="10B9F7B7AED9859D" modified="2021-09-29" version="1">MSKRLLLPDIRLLFFLFLSFPFLSFFSSFFFHFSFFLFIFLSFYLFLPSFFFFLSFFFLTFLFLSFLLLFFTFCFFFLFLLYLFSFFLLFLFFSFLFSFLSFSFHFFIFLFSLLSFYLSFFFSFFFLSFFLSFFFHFSLIFLSFFLSFSFYLSFLLLSFSFSFFSFSFLFLSFFSHFSFFLFPFFLSFPSFFIFFLSFPSLSFLFPFSFIFLSFFFLSFFSPLSFFPFTFLLSFFFFLSFIFLTFFSKTPHSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D2T0</accession>
    <name>A0A812D2T0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_48293</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002671">
        <property type="protein sequence ID" value="CAE1290605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D2T0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1290605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="210" mass="24191" checksum="E78038B708B6CB99" modified="2021-09-29" version="1">MEQGIFLSISFLLSPSIYLSIYLSIYLSIYLSIYLFPSLSLSINLFIYLSIYLSIYLSISFSISFSLPLYLSIYLSIYLSIYLYLSVTFSLSLFLSLFIYISIYLSIYLSISFLLSLFLSPSLSIYLSIYLFPSLSIYLSISFLLSLFLSPSLSIYLSISFSISFSLPLYLSIYLSIYLSIYLFPSLSIYLSLYLSIYLSIYLFPSLFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D4S4</accession>
    <name>A0A812D4S4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">CDH23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SPHA_47502</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002578">
        <property type="protein sequence ID" value="CAE1289121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D4S4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016342">
        <property type="term" value="C:catenin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045296">
        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034332">
        <property type="term" value="P:adherens junction organization"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016339">
        <property type="term" value="P:calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044331">
        <property type="term" value="P:cell-cell adhesion mediated by cadherin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007043">
        <property type="term" value="P:cell-cell junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="2"/>
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        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039808">
        <property type="entry name" value="Cadherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
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        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027:SF422">
        <property type="entry name" value="CADHERIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027">
        <property type="entry name" value="CADHERIN-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    <keyword evidence="5 8" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0732">Signal</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032769794" evidence="10">
        <location>
            <begin position="17"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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    <feature type="transmembrane region" description="Helical" evidence="9">
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            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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            <begin position="408"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="457"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="495"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="530"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="555"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="589"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="631"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="675"/>
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    </feature>
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        <location>
            <begin position="717"/>
            <end position="740"/>
        </location>
    </feature>
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        <location>
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    </feature>
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        <location>
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    </feature>
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        <location>
            <begin position="873"/>
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    </feature>
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        <location>
            <begin position="901"/>
            <end position="919"/>
        </location>
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        <location>
            <begin position="931"/>
            <end position="954"/>
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        <location>
            <begin position="974"/>
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        <location>
            <begin position="1015"/>
            <end position="1034"/>
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            <begin position="4"/>
            <end position="38"/>
        </location>
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            <begin position="40"/>
            <end position="144"/>
        </location>
    </feature>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAE1289121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1036" mass="113291" checksum="3928074FB0EAC0BE" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D529</accession>
    <name>A0A812D529_ACAPH</name>
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        <submittedName>
            <fullName evidence="3">RUSC2</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">SPHA_45455</name>
    </gene>
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        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
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            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
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            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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    </dbReference>
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            <end position="1362"/>
        </location>
    </feature>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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        </location>
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        <location>
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        <source>
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        <source>
            <dbReference type="PROSITE" id="PS50826"/>
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        <source>
            <dbReference type="EMBL" id="CAE1285499.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
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        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002889">
        <property type="protein sequence ID" value="CAE1293453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D5J6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="282"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="312"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="348"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="381"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="409"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="435"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="459"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="495"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="523"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="552"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="579"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="605"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="629"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="659"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="703"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="729"/>
            <end position="751"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1293453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="783" mass="92170" checksum="067CB1583576744F" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D5S1</accession>
    <name>A0A812D5S1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_49185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002789">
        <property type="protein sequence ID" value="CAE1292267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D5S1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="284"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="316"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1292267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="342" mass="42296" checksum="16C47D54A5CCE4A0" modified="2021-09-29" version="1">MKLFILSIDFSLFFFFVFLLLLFFGFICCFFFWFSLLLFFLVFFVAFFFGFLCCFFFWFSLLFFFVFFVAFFCFLCCFFFLVFFVALFFFGFLCCFIFFWFSLLLYFFGFSPLYFLVSLSPLYFFFGFLCCFSFWFSLLLFFLVFFPLFFWFSPFSFGFFFAFLLVFLLFFPTPLYSFFFFVFFCCFFVFLFAFWGLLLFWFLCCFFFFFFLCCFFVFFVAFFGVVVAFFCFLCCFFFVFLVAFLFSLLLFFFFFFVAFFFVFLCCFFCFLCCFFCFLCCFFCFLCCFFCFLCCFFCFLCCFFGGVVAFFVFFVAFFLVFFVAFFLVFFVAFFFLFFFVVHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DAM5</accession>
    <name>A0A812DAM5_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Palmitoyl-protein thioesterase 1</fullName>
            <ecNumber evidence="2">3.1.2.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Palmitoyl-protein hydrolase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SPHA_52425</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Farmed</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the palmitoyl-protein thioesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.22" evidence="2"/>
    <dbReference type="EMBL" id="CAHIKZ030003261">
        <property type="protein sequence ID" value="CAE1298140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DAM5"/>
    <dbReference type="OrthoDB" id="10263094at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006898">
        <property type="term" value="P:receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000107">
        <property type="entry name" value="Palmitoyl-protein thioesterase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002472">
        <property type="entry name" value="Palm_thioest"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247:SF8">
        <property type="entry name" value="PALMITOYL-PROTEIN THIOESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247">
        <property type="entry name" value="PALMITOYL-PROTEIN THIOESTERASE/DOLICHYLDIPHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02089">
        <property type="entry name" value="Palm_thioest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00414">
        <property type="entry name" value="PPTHIESTRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAE1298140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="262" mass="29963" checksum="9FAA70DAF3BEBBC2" modified="2021-09-29" version="1">MGDSCCNPMSMGAIKTYIEKNLPGIYVRSLMIGANVIEDTENGFLMNVNDQIREVCKKLASDEKLAKGYNAIGFSQGGQFLRGVAQRCPVPPMQNLISVGGQHQGIYGFPHCPGNNSTICDMIRKLLNSGAYLNVVQAEYWHDPLQEEEYKEKSVFLADINLERPSKLPYKENLLQLKNLVLVKFNKDTMVYPKESEWFGFYKPGQGKEVYSIWESPLYKEDRIGLRKLNDTGRLHFLGIDGDHLKIKLEWFKENIIERFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DBX2</accession>
    <name>A0A812DBX2_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Small ribosomal subunit protein mS39</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SPHA_50922</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003041">
        <property type="protein sequence ID" value="CAE1295454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DBX2"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043024">
        <property type="term" value="F:ribosomal small subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037387">
        <property type="entry name" value="PTCD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055063">
        <property type="entry name" value="Rib_mS39_PPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16276">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16276:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22330">
        <property type="entry name" value="Rib_mS39_PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0810">Translation regulation</keyword>
    <feature type="repeat" description="PPR" evidence="12">
        <location>
            <begin position="254"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00035134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAE1295454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="657" mass="75918" checksum="A2A70D754E771FE9" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DDC8</accession>
    <name>A0A812DDC8_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SPHA_51679</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003142">
        <property type="protein sequence ID" value="CAE1296754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DDC8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="189"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAE1296754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="219" mass="26368" checksum="9DD43CD8A0B0330C" modified="2021-09-29" version="1">MISFLLSFLSFLFFFLSSFFPIFLSCFFACFLSFLLSFLTSFSFFLSFFLCFFVSFFLPSIFLYLFFLSFFFFFLSFFRFFFFHISLISFFNISFLFLYLLLFSFFLSFFLSFFLIFFLSFFFLIFFLSYFLSFFLSFFLSFFLSFFLLPNFLIYPSSSSRLDISTGANYPRNSRLLGSKSTGICKNIFGLYLSIYLSIYLSIYLSIYLSIYLYLFVSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DEI6</accession>
    <name>A0A812DEI6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SMG9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_54336</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003531">
        <property type="protein sequence ID" value="CAE1301328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DEI6"/>
    <dbReference type="OrthoDB" id="79514at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039177">
        <property type="entry name" value="SMG9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14270">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY FACTOR SMG9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14270:SF0">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY FACTOR SMG9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1301328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="385" mass="43535" checksum="E0B6F78A361E718C" modified="2021-09-29" version="1">MIHHDKKYPAEYSTAENCMEMQSLQLAAFMMTVCNVLLVVQDWFTDINFLRFLLTAEMLKPSTPNSHDGPSVQETSSDYYPQLVFIQNKATRDDFSVETFRAMQTTLSKVFSNSKLKYTGSVTLANGDLLPGLNPRTVPSNINLYLLPYMDNQKTEGDSILTFLPEYRGYPSFSRLLQSLRNQVFASQRCLLTHTILSEKNWFHYAARTWDAVKKSPLMGPPEWGRARITLFSRTSNPFFPSIGVRVVPFGVVHLSPERTYSSKVTAPTPLLRIVSFIDLSAMSKQWQPKSDLPEVRHSVFCFFFLLFLPSLFLLMSLPDKYCLKARVLSGLTRSRLDKTNATFSPLSDSHGNSHGYSGVPPPTARPGQFSLLSSRIFSRSAFSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DEK6</accession>
    <name>A0A812DEK6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_52060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003205">
        <property type="protein sequence ID" value="CAE1297459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DEK6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="134"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1297459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="163" mass="18835" checksum="AFDDE069D3CD1004" modified="2021-09-29" version="1">MTPNILAQEGEGGITVISNSTTTSSSSPPPSSSSPPPRPPSSSPPPSSSSFILVLFFYSPILFIFLFRPCFFRFFFSLSYSLFILCGFHYFLLFLYLVYSFSFFLSSASSPLFCYLFFYSLFMHPFESLYLCPFFTFLFFFLFTFVLDFLVPFLFLSFFLSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DFG0</accession>
    <name>A0A812DFG0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_53162</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003358">
        <property type="protein sequence ID" value="CAE1299310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DFG0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1299310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="253" mass="29554" checksum="E7C067A42E68C9B4" modified="2021-09-29" version="1">MYLCDHWTLLLWLNYVPFHHGTYICDPINIYLSIYLSIYLSICIVPIIICSYLSIYLSIYLSIYLSIYLRLVISISVYDCIYMCIFTTNIIYLSIYLSIYLYLSIYLYLSIFPRKSLPNPYNGVVNDVIGYGLRMLAICFLRGIGHSRSRWSVLSFFLSFFLFPLSLFKGLMTVENAFFLFDIAAFRLRRQNGSIHSTGRPILLTILQTHLFSPYTETFAKRPSSPQAWTKTNFSVSLFISVFFLSRGQFSKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DFL4</accession>
    <name>A0A812DFL4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SLC46A1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SPHA_54384</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003536">
        <property type="protein sequence ID" value="CAE1301401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DFL4"/>
    <dbReference type="OrthoDB" id="3026777at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF1">
        <property type="entry name" value="FI18259P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAE1301401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="187" mass="20025" checksum="1C2D2174E926AD2D" modified="2021-09-29" version="1">MACSALGTVLAVPFLRHHVSDTTIAIVGLVSKAAGTLWIGVIQSEAVLYFSILLLAFQLLPFPMMRAIVSRGIHPTDQGSLFALMHCGESLIHFLAPLIFTVIYASTLRFYTGFIFIVAAIMLLIPAGFTLGIKFLDAKINVDYQAMEDRGTELATSPSVASSINFDDIASIASSQNNAPISTISVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DGN1</accession>
    <name>A0A812DGN1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_53901</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003443">
        <property type="protein sequence ID" value="CAE1300417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DGN1"/>
    <dbReference type="OrthoDB" id="6508726at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1300417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="161" mass="18227" checksum="5775B24C933A2624" modified="2021-09-29" version="1">MDQDLSLMKQLLILNEAIEDLKVQRGYLSSRGSLPSSSCDLSESQWSVSETEMFESENELTNKYPSPSTLSLNNEDKTKITSDFDDIINEANEKLCITKKLFDKKSTPSSQVTGDKKNNAILDNNKNIFVENDFNASKRARHEEQNSFDSGIHEPHYVDSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DH51</accession>
    <name>A0A812DH51_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_51684</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003142">
        <property type="protein sequence ID" value="CAE1296837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DH51"/>
    <dbReference type="OrthoDB" id="10013584at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031462">
        <property type="term" value="C:Cul2-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22619">
        <property type="entry name" value="ZINC FINGER SWIM DOMAIN CONTAINING PROTEIN 4, 5, 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22619:SF0">
        <property type="entry name" value="ZINC FINGER SWIM DOMAIN-CONTAINING PROTEIN 6-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="304"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1296837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="327" mass="38693" checksum="5D9281086A18AF0F" modified="2021-09-29" version="1">MDAFFLSFFLSFFLSFFLIFLTFFLTVSFPPISFSFFFFILFYFLLYFSFFSYSFFPLLIRSFFSFLVLSFLSFLIASFFPVFHSDCRRHRPLFFAILLILDVRKLPAEPHTLPWSFYTSTTTSVTASLPDNIRCFPMAMVKRLCLSFPREPARGQWNYNKHGAPDSVQTHCGQVDTLLDICAKVVAENIPFQSIEQRFDRIPEPVQSRIVYWSFPRNETDICMYSSFSNSWKDNNGETQKLPFHHGVRLLENECVDNVLQIGQSIIFLFFFSSFKSRIFLLLLRSYAADIFLLLQFIHPLPFYIYIFNFFFFFFLSGLSIYDRLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DIH7</accession>
    <name>A0A812DIH7_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Tubulin alpha chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SPHA_57359</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Farmed</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="11">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003869">
        <property type="protein sequence ID" value="CAE1304839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DIH7"/>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02186">
        <property type="entry name" value="alpha_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000005">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000001">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000002">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="13">
        <location>
            <begin position="49"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="14">
        <location>
            <begin position="248"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="430"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="431"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAE1304839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="451" mass="50300" checksum="44A74768860E67D3" modified="2021-09-29" version="1">MRECISIHIGQAGVQIGNACWELYCLEHGIQQNGQVPDLKTQSNGDDSFNTFFSETGGGKHVPRAVFVDLEPTVIDEVRTGPYRQLFHPEQLISGKEDAANNYARGHYTIGKEIIDLVLDRIRKLTDQCIGLQGFLVFHSFGGGTGSGFTSLLMERLSVDFGKKSKLEFSVYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPSYTNLNRLIAQVVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLVTYSPIISAEKAYHESLSVSEITNACFEPANQMVKCDPRNGKYMACCMLYRGDVVPKDVNQAIATIKTKRSIQFVDWCPTGFKVGINYQPPTVIPGGDLATVQRAVCMLSNTTAIAEAWARLDYKFDLMYAKRAFVHWYVGEGMEEGEFAEAREDLAALEKDYEEVGGDSDEGGAEDEYEEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DIS6</accession>
    <name>A0A812DIS6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_56811</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003794">
        <property type="protein sequence ID" value="CAE1304114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DIS6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="131"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1304114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="206" mass="24407" checksum="4F69052294C818F2" modified="2021-09-29" version="1">MFFFLFCFCFFFLSFFRSFSLFHLSFYSRFLFFLKFFLFSVLFVIFILDLVSSSSFSTSSSSSSSSSSSSSSSSSSSQKISFISPNPVRPTTYISFFFFFSFFFFSSFSSSSFSFSSFLLFFFFFFFFSSFLLLLFLLFSSSFLLLLLLLLLLLLLHNSRYRFPFHFSEIHSSFRILTRHFPSFFPSIIPHLFSNRYHHTELHKHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DIZ4</accession>
    <name>A0A812DIZ4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_55018</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003633">
        <property type="protein sequence ID" value="CAE1302540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DIZ4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1302540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="306" mass="36160" checksum="1575B308DE94B25C" modified="2021-09-29" version="1">MCIFTTNIYLSIYLSIYLSMSHHTVFLYIYCNLYFFSYLFQSPQIHKSIYLSIYLSIYLSIYLSYSFYLSMRAQSLTLCVSLSLFHSLSLFSLSIYLSIYLSIYLSIYIYIYDYRILRPPNSDTATPVINMPSISMRKRLYFIYLSIYLSIYLSIYLSYLSYLSIYLSIYLSIYLSILITYLTQSIYLYIYLSIYLSQYINYVSNNLSFNLISFLSIYLSIYLSIYLSILPISIYLSIYLSIYLSIYLSISIYYVSNNLSFLLSFYLTSFLSIYLSIYESQFVNIYQSIFISFSYSNVMAGLKADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DJC6</accession>
    <name>A0A812DJC6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_57461</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003877">
        <property type="protein sequence ID" value="CAE1304956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DJC6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1304956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="167" mass="20577" checksum="FBE00E558FEB6872" modified="2021-09-29" version="1">MDGKTGEIIFFFSLLFLLFPFSSFPCFLLFLSLLFPFSSFSSFSFLFSSFFFLFSSFFFFSLLFSFSFFFFFLFLFFSFPFSSFLFSFLFFFFLFFFFFFSFFSFSSFLLFSFLFFSSFSFFLSFFSFFPFFCLLFLSFLFFFFSFSFTFFSFSFTFDFLLFLQYPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DL38</accession>
    <name>A0A812DL38_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_54203</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003505">
        <property type="protein sequence ID" value="CAE1301118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DL38"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="333"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="389"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1301118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="430" mass="46966" checksum="554465CA19897598" modified="2021-09-29" version="1">MAAITISHTYNCQTFKYFGTTHIPSLSFSLSLSLCLSIFFTLSLSFSPLSLSLSFSLCVSLSLSLSLFLSVFLPLSVSFFLTLCLSPFLYMVATQKALRIDYIRVSKLTSAADAFFLQSAAEVIITRPFRFKPHKRIGFQYYILSTLYKKLFFNDISSSSSSSSSSSSSSSSSLSLSVYFSVCLFLSATLSLSLSLILSLSDSLTLSLSLSLSLLFFTLSVSVSFSLSFFMSPSISLFLSLFLSLSLYLSISLSFCVYVCLSLSLSVSLSLPFFTLSLSLSLSLCISLSLSLSLSLSFSFSFSLSLSLSLSLFLSLFLCVCLSRSLSVFISSFFHSVSFSVSFFMSLSISLFLSLSLSVSSSLSLFLSLPLYLSISLFVCLSRSLSLSLSVFISSFFHSVSFSLSFFMSFAISLFLSLSFSTGDIYSCIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DNJ2</accession>
    <name>A0A812DNJ2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_59258</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004104">
        <property type="protein sequence ID" value="CAE1307203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DNJ2"/>
    <dbReference type="OrthoDB" id="9832999at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="450"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="484"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1307203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="545" mass="62980" checksum="4101793FFDCE331F" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DNN5</accession>
    <name>A0A812DNN5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_57658</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003892">
        <property type="protein sequence ID" value="CAE1305178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DNN5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1305178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="215" mass="25768" checksum="6AD6EADB3D9282DA" modified="2021-09-29" version="1">MWFFSHSSLFPYSLSLSLSLSLSLSLSIPFLSFFLSFFLSFFLSFFSVRSYLSLTIHIFLMSLNFVSPFPPFFIFPWCFLFFFSAFFSAQLTLLIFVIMKALRFPSVYRQTLIQTLVYFFLSYFCPFFLSFFLQFLRHLLLFSNTLHYSFSTDIILEKKKPSIFLFFARITPKASFPTDHPFTFLFCHRFFFFFFLKKKKTTNIYLSFLTILPTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DP38</accession>
    <name>A0A812DP38_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_59785</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004146">
        <property type="protein sequence ID" value="CAE1307816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DP38"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1307816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="347" mass="38608" checksum="B069EBF487B03243" modified="2021-09-29" version="1">MLLTGVYLYVSSSIQSSKTVTIITIVSFLSFFHIYPRKEKRLIQFYFVDLSVRSRLASPRLHNRLCQISRWFKFLRDNRGLFLNICYGATYQALTRTITSAVHAWGPFHATHNTDDNCPVSHRPLLIRHNHCTDSTYSLGSGCTAPLNRSFSGNSSLTPGASSSRNLLCNCAYGISSSSSHSLSSSSSLSKRYTCAFLLPACSLHFFRLLDNRDTVAGNRSSPLSSRGCSVLRGLTFSCEDRFVLGDPILHIANTFTLYNWPKDARPHDMSSISEVLLALWPLCLLLFPGGPIGVSRTLFLLRGVGYPQFTVPLRRTPSSLMPELATNCTVRLPRSWIASIIGPVWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DRS0</accession>
    <name>A0A812DRS0_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TLC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SPHA_60991</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004276">
        <property type="protein sequence ID" value="CAE1309234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DRS0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="7">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAE1309234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="207" mass="26007" checksum="0CC9C0A8EC3C7C48" modified="2021-09-29" version="1">MIGFLRSIFSFKFFFRFSFSLISLSVHLFLSIIVYFLFFLFSSFLFLSFYFLFHFLFSLFLSFSLFLFTLFFTSFSFFYFLLFLLFLFSIFLFSFFSLFFFFLSSLFLFLSYLCLFLFFISFFFLSSFFFFFLFSFFFLLFSFFFFLFSFSFFFFLSFFFLSFFLLSSSFFFFLFFFLFSFFLFFFLSFFFLSFFFLSFLFSFFFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DTS1</accession>
    <name>A0A812DTS1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_60623</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004221">
        <property type="protein sequence ID" value="CAE1308791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DTS1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1308791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="288" mass="33804" checksum="5026704B53857C99" modified="2021-09-29" version="1">MPSPLIFPRNIYKTTGFEVFFLLMDCFHRTLGAPSVPTCLYSHFYLSIYLSIYLSSFPHFYSHSVKIYLSIYLSIYLSIYLSIYLSIYLSTFDLIYQSVCLSQSVHLSIYLSIYLSIYLSIYLSISMHLSIHIYLYQHIQLISFYLSIYLSIYLSIYLSIYLSIYLSICSCLPNASSVCIHIYLYQCIQLISIYLSIYLSIYLSIINSDINYLCHQINYLPPSLSFSISLYIYLSQSLHIYLSIYISIYLSIYLSKFITSLSINLFYTHYDLLSFMKEVSLFSNYNII</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DX52</accession>
    <name>A0A812DX52_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_61909</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004391">
        <property type="protein sequence ID" value="CAE1310320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DX52"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032568141" evidence="2">
        <location>
            <begin position="24"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1310320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="303" mass="34000" checksum="15F4A1D864A33B93" modified="2021-09-29" version="1">MFHQTSSVPTFLSCLCFFLSVSSDVKHPLHKLSPTSENEARRNVQEKRFPGFSFFLFDKLHLSPLLLPTIVSFSCLPAYQDLSIYLSIYLSIYLSIYLYPSESIHSHYLSIYLSIYLVLSIYLSIYLSIYLFSSSSSSSSSSSSSSSSLSSSLLLLPVFFFFTHVHIFPPSSSSFSSSFSSSSLLLLFHFLLLPCLFLLYLLLLPRPHPSASSSSAATAAFFFFSLVVIPLPPLLLLPRPHPSYSFSFFFFFFFFFPPLSSSSSSSSSSFLLYLVLSRRHPSSICRIPSKRGPMLALLTPSFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DYH4</accession>
    <name>A0A812DYH4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SCYL3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_64565</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004639">
        <property type="protein sequence ID" value="CAE1313413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DYH4"/>
    <dbReference type="OrthoDB" id="9942861at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051177">
        <property type="entry name" value="CIK-Related_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984:SF15">
        <property type="entry name" value="PROTEIN-ASSOCIATING WITH THE CARBOXYL-TERMINAL DOMAIN OF EZRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984">
        <property type="entry name" value="SCY1-RELATED S/T PROTEIN KINASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1313413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="638" mass="72364" checksum="87E3C38CD82522C5" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DYI4</accession>
    <name>A0A812DYI4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TRIM24</fullName>
            <ecNumber evidence="7">2.3.2.27</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SPHA_63921</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="7"/>
    <dbReference type="EMBL" id="CAHIKZ030004595">
        <property type="protein sequence ID" value="CAE1312691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DYI4"/>
    <dbReference type="OrthoDB" id="6020909at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042163">
        <property type="entry name" value="PHF12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46309">
        <property type="entry name" value="PHD FINGER PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46309:SF1">
        <property type="entry name" value="PHD FINGER PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="194"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="146"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="146"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAE1312691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="232" mass="25709" checksum="97F0CDBF206F77B7" modified="2021-09-29" version="1">MCISFSIERKIKIFFLFQHLLVVEPKGNLSFCLYCAFLVLLPSLFQAIIPCKTFFVCICIAFLCLSLSLSLSLSLSLSLSIYSKSSVQILKVKKEKTNTSCCNGGPTVVSKFIPNLEKALNNLPLDTSDLIPSHMSESFSMSSVAQQQQQAQQQQHQQQQQQVQHRQQAQKQVQSSISNNLDDVGSDDPNEDYCACCRNGGELLCCDSCPKVFHLQCHIPALMGAPSLSPTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DZ08</accession>
    <name>A0A812DZ08_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_65101</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004686">
        <property type="protein sequence ID" value="CAE1314043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DZ08"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1314043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="247" mass="29284" checksum="B3B522C1A7C7A9C6" modified="2021-09-29" version="1">MKIYLSIYLSIYLYSYLSIYLSTYLSISLHIYLFLSLSIYISLFISIYLSIYLSIYLSISLQMSALIECFILHLPSICSFFLPPSQLFHNHIYLTVIIYLSTFMYVCLYLIYVSLNLSIYLSIYLSIYLSIFIYKSNRISNALLTTWREVKHARIMAVEMRRQFLPSTISFFLSFFLSFFLSFFLFLQLSTFSFPPFFLFTFPHPLPCISLLEFHILFPFSMCSHLVLILIAIFLILLTCKYSFFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DZ50</accession>
    <name>A0A812DZ50_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="14">NDC1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SPHA_64255</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NDC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004626">
        <property type="protein sequence ID" value="CAE1313073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DZ50"/>
    <dbReference type="OrthoDB" id="67850at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070762">
        <property type="term" value="C:nuclear pore transmembrane ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019049">
        <property type="entry name" value="Nucleoporin_prot_Ndc1/Nup"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13269">
        <property type="entry name" value="NUCLEOPORIN NDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13269:SF6">
        <property type="entry name" value="NUCLEOPORIN NDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09531">
        <property type="entry name" value="Ndc1_Nup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="10" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="192"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAE1313073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="572" mass="65883" checksum="7527F7F4F7679BCF" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DZC4</accession>
    <name>A0A812DZC4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_64317</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004627">
        <property type="protein sequence ID" value="CAE1313185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DZC4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="424"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1313185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="447" mass="48663" checksum="F0EDB4D2C68AFB7E" modified="2021-09-29" version="1">MQGVRLRQTKAFLRDLRMPLKAGIQGSGYAPSSRRTNRVVEGLVSIDRSVVAALRHDTPSLNSSGLRAIPFVSTLHGVRKSSATAKSFRLSRISNQVADAQTPHSRATTAEVADAHGNDGATDADHDVQPPPSDNDARMAGSSGTKRDAFSVFARRQRRTAARSSEHANRCSDPAVPLVLDGIAVATADVTRVPIELTSGKDQKATSLRTLGRHKPVITVVTFRHLSRNGALRSERIDGPRFRGPYSPKIDGPLSSPLDTWCYCLTDVARPSQTSPARHGPWRRVERGLQSAGARALALVRGLLSDPSPFTGFDDTERRRSRRRPETGTNETPAHRRRRRPRPTEKKTEAGGEEERRRREAKPPTTGRKPKVPDRIRYRQTKLTPTATDGCRPAPDQRAPNADKGVSPAYATPPVSPHRVGLESSSTGSSFPAGSFQARSLGCGFAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E0L4</accession>
    <name>A0A812E0L4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_63780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004577">
        <property type="protein sequence ID" value="CAE1312475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E0L4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1312475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="202" mass="23615" checksum="6AC72BB464E13DE9" modified="2021-09-29" version="1">MPVRNDLYGSCGKVAFNLSIITPTIESAQIEHNLFIVQFYNLRNTPKNESNLSIYLSIYLSIYLSIYLYTYIYIRDLWALMPASVSLLLTVRVDIDLFLASRNSAVTLEERYTLILGKFWTGKKTRRHYIYLSIYLSQCVHYLSIYLSISVCSLSIYLSIYLSIYLSIYISVFIIYLSIYLSIYLSVCLSIYLPNYLFIYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E376</accession>
    <name>A0A812E376_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_63832</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004586">
        <property type="protein sequence ID" value="CAE1312612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E376"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="326"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="419"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="458"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1312612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="505" mass="58878" checksum="355AED4DACBAF233" modified="2021-09-29" version="1">MIWTYNCSLGFSFLPFFLPSSHLLSSFFFFFSFLNIFHFSFFFVFPSLILQIFLLPFPFFSSFLFLSFYSISSFFFPFFLLFLFFLFFHFFLLKILSFIFLPSFIFLFSFSFFFSFSFLLSSFHCSLPLFFFHSSPLSYPSFIVPLCNLKSFSPSFLSFFLPSFIFLFFSFLLLPFPPIVFFIASLPLFFSILSPFLLSSLHCSLCSEFIRFLLPSFFLSSVFIFISFFLFFFLSSLPSYRLLHCSLPLLFFLPFPTILSFIAPFVRSFIFSFLPFFLPSFIFLSFLLFFSSPPLPSYRLLHCSLPLFFSIPLLLYYPLLHCSLCAFVHFLLPSFLSFVFYLPFFTSFLLFHSSPPLPYYPLLHCSLHAFVRFLLPSVFYLLSFFLSSFPYLSFPSLLSSSSLLPLCVRSFSPSFLPSFRLLFPFFLPFLSSPPFLSFPLPPSLSSSSSLLPSFARSIFPSIFYLLSFFLSSPSLLPSFLPSVVRGKKLFERNLLLTDGIKRICG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E3Z9</accession>
    <name>A0A812E3Z9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_66157</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004770">
        <property type="protein sequence ID" value="CAE1315228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E3Z9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1315228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="258" mass="30512" checksum="A9B21E8C0932A532" modified="2021-09-29" version="1">MCSHCGFIDFYCCKESQNSFLSIYLSIYLSIYLSIYLSIDRSIYLSISISFFFLLNLLTSISVSFFLVSFFLFHSFFFLTYFLNLLTFIPFSSFFIFLPFVCSFVSIYLSIYLSIYLSIYLSISVSFFFSFTASFSFFYSCHLFLFSLFLIYLFLSCFFLYFILFSFFLNLLTSISVSLFLNLLTSIYHSLFGLFVCLFVCLFVSFFLSFFLTFFLSFVCLFVRSFISIYLSIYLSIYLSIYLSIDQKLLKISIKSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EAR1</accession>
    <name>A0A812EAR1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_71442</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005233">
        <property type="protein sequence ID" value="CAE1321350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EAR1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="372"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="463"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="496"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1321350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="547" mass="57353" checksum="AED9AA4EF00F2E80" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EAS2</accession>
    <name>A0A812EAS2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_71580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005241">
        <property type="protein sequence ID" value="CAE1321517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <end position="28"/>
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            <end position="131"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="1337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1344"/>
            <end position="1368"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1321517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1379" mass="170176" checksum="3A2D3AF04199F4E3" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EDG6</accession>
    <name>A0A812EDG6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_73117</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <location>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAE1323261.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="167" mass="19905" checksum="A2F7B1098979CF53" modified="2021-09-29" version="1">MFFTFGIICFDVPETFLLNLLYCRFFHWRKSEKERERERERERDQNVIRISLSLYLFLSLFIFIPLYFSLSLSLFLSIFIIISLSLSLYLLLSFYLFLSLSLFLFVFISISIYLSVPPYLSLSLSLSLCYMLNIFCNAHRKQYLSIYLSIYLSIYLSTPLYVGLRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EIE5</accession>
    <name>A0A812EIE5_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SPHA_76061</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005479">
        <property type="protein sequence ID" value="CAE1326478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EIE5"/>
    <dbReference type="OrthoDB" id="5918172at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031890">
        <property type="entry name" value="Fbxo30/Fbxo40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15933:SF20">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15933">
        <property type="entry name" value="PROTEIN CBG16327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15966">
        <property type="entry name" value="F-box_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="F-box" evidence="3">
        <location>
            <begin position="168"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAE1326478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="303" mass="36370" checksum="10C4818DB636AB36" modified="2021-09-29" version="1">MAAVDVFFPNSRLDSFFLHFTLHLFLPSYIQVELKRASLFTSCHTFSLLFLFVFFFLIFFLFLIFSFSHFFLFLIFFFFSFFSFSHFFLFLIFFFFSFFSFFFVFVYFLSLFLSPFFFFSLYFFLLSLLFFSLLVFLFILSLFIFSFYHSPLLWRFPVVGILLHIIWHIAITSKRLREACANLLEERGLVTQIWQKEVLEGSNKCHWKVAYKKWNFSPAFTPVKFWGFNGHNPLSEHLKVCPFNQDPARHSQPFHLPSDSKAATRLSHQHSPKHNPDEQQEHPQQPHPFYAQFDDVPELNLQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EL01</accession>
    <name>A0A812EL01_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_75074</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005450">
        <property type="protein sequence ID" value="CAE1325434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EL01"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1325434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="245" mass="28761" checksum="81D757B63AF0C4ED" modified="2021-09-29" version="1">MFIFFSSHLFLTFFFRLSLPFLQHHIFTLRLNLIFTISPRSFSPPSYLYLYFSLLSLHFFLPLNFTFTSPSYLYLYFSLLPLPLLLPFTFTFTSPSYLYIFSSLLTLPLLLPLTFTFLPSYLYIFPSLLSLPLLLPLTFTFTSPSYLYIFPSLLSLPLLLPFTFTFTSPSYLYIFSSLLTLPLLLPLIFTFTSPFYLYLYFSLLSLYFLLPLNFTFTSPSYLYLYFSLLPLPLLLPLIFTFSPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ENW3</accession>
    <name>A0A812ENW3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_79225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005562">
        <property type="protein sequence ID" value="CAE1329849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ENW3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1329849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="178" mass="21359" checksum="2F4F8C4057051B4C" modified="2021-09-29" version="1">MSIYFILHYLSIYLSIYLSIYLCHFIDQSIYLSIYLSIYLSIYLSIYLSIYLSSYGLVKNYLYIYLSHSVYYLSIYLSIYLYCLISTWSLNINTASYLQSRRKRESIYLSIYLSIYLSIYLSIYLSICLSVCLALYGLSFFLSFFLSFFLDWLMELLAFFLPFFLSFFLSFFLSFSFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EQI5</accession>
    <name>A0A812EQI5_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lipid-binding serum glycoprotein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_80176</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005593">
        <property type="protein sequence ID" value="CAE1330930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EQI5"/>
    <dbReference type="OrthoDB" id="6128836at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.20.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017943">
        <property type="entry name" value="Bactericidal_perm-incr_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032942">
        <property type="entry name" value="BPI/LBP/Plunc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001124">
        <property type="entry name" value="Lipid-bd_serum_glycop_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10504">
        <property type="entry name" value="BACTERICIDAL PERMEABILITY-INCREASING BPI PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10504:SF131">
        <property type="entry name" value="BPI2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02886">
        <property type="entry name" value="LBP_BPI_CETP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00329">
        <property type="entry name" value="BPI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55394">
        <property type="entry name" value="Bactericidal permeability-increasing protein, BPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipid-binding serum glycoprotein C-terminal" evidence="1">
        <location>
            <begin position="142"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1330930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="352" mass="40774" checksum="9F0C88E85420B222" modified="2021-09-29" version="1">MEVEEYRVHCAYSVLDQPLRVDIPTESLSLSISLYLSLSLSLSLPFAALNQRIYIRRHGLKWIISMENLRISCSWKYSKKQWWFTFSHTGTLQLTSLNSQIEITTSLSSFFFFHFRHFQAIISYENDQRIIPFTAKPLPNISENNKMVYFIISNYVLDTMLFSAHENNVFKYTVNRENLPDGSHEFFHTTCPDSFCIGTILPQFAVTFPNTTIEIYFSTFDRPRTYFYPDKIQMSIPTQLQFSTLQSNLKKTTVFNVYLNVSTLVKAQFKENKFYLSIANISFIFGQLSGPYADKFDVAKVEKGLQTMFNELTPFINSIGTTVIPLILPQQTSIFNPEFRIVNVSIIFISAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ER32</accession>
    <name>A0A812ER32_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_78807</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005552">
        <property type="protein sequence ID" value="CAE1329342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ER32"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="297"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="332"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="377"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="408"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1329342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="449" mass="53142" checksum="DDE4AD7D39FE0CDC" modified="2021-09-29" version="1">MVAYFLPFFLSFQICYLLFSVFLPFQIIQGLFFFLSFVLSFQQLNGCCFLSFFSSKSVVVFFFLSFHLSQWLLSFFLSFHLINGCYLSFFSSKSVVVFFFLSFFSSKSMVAIFLSFFSSKSVVVFFFLSFFSSNQWFSSFFLSFHLSWLLSFFLSFHLSQWSFSSFFLSFFSSKSMVAIFLSFFSSNQWLLSFFFHLSQWSFSSFFLSFISSKSMVAIFLSFHLSQWLFSSFFLSFFSSKSMVAIFLSFHLSQWSFSSFFLSFFSSKSMVAIFLSFFSSKSVVVFFFLSFFSSKSMVAIFLSFHLSQWSFSSFFLSFHLINGCYLSFFSSKSVVVFFFLSFFSSKSMVAIFLSFFLSFHLSQWSFSSFFLSFHLSQWLLSFFLSFFSSKSVAVFFFLSFFLSFHLSQWLLLFSFFLSIHLSQWFLYFFLSSFHRSQWLFSSFFLSFFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ESF2</accession>
    <name>A0A812ESF2_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SPHA_79476</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005569">
        <property type="protein sequence ID" value="CAE1330127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ESF2"/>
    <dbReference type="OrthoDB" id="6022136at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053207">
        <property type="entry name" value="Non-NMDA_GluR_Accessory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47537">
        <property type="entry name" value="CUBILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47537:SF2">
        <property type="entry name" value="CUBILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CUB" evidence="3">
        <location>
            <begin position="75"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="3">
        <location>
            <begin position="205"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAE1330127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="401" mass="44661" checksum="25601BC942BBC3FD" modified="2021-09-29" version="1">MLGYLAVNLKGQISPRKYHDKFCGELLPPELTSENPRLVLILNTHGAVRGRGFLARYEFITDYNIPGKQIRDGMCSFLYDSKDTRKGSFNSPGHPGLYFINLDCTYIFRGKPHEKIAISFEVFNLPNNDPHSCKATDYIEIYQQLEGPNNYSVIRRYCGKANPGPILTERGVKILFHSDSDGIDMGFRASYEFIKKEDINKETDCSKTVLANERWGGFIQSPDYPLKYKPITHCEWNIIAPSNSSRILLQFTVLKLEGQGNSDQIENSCPRAVIRIYSNADGIKPDKELCGVWKQGYSFVAKSHSVRVSFLSSSRSLGAKGFNLAWTELRGTGKCDGFKCAQSGYCIAPQLKCNQLPNCGPQDESDESTEVAQCGIGPVISEPMILGLSVLISVSVGLILH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ET75</accession>
    <name>A0A812ET75_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_79946</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005584">
        <property type="protein sequence ID" value="CAE1330649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ET75"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1330649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="257" mass="31365" checksum="557709A03B9EC3B7" modified="2021-09-29" version="1">MFFLSIYLSIYLSIYLSIYLSILVCIGLVWFVLRHINLNGLFNADKIFCWLFLVIFFLQKSIYLSIYLNFFFWFTDIIFFFYCFISKCIASFLSIFLFIYLSIYLSIYLSENNSCGKPDNVFPPSLPFITLYLVFFSFIYITVRFLSFFFVCLSFFCFFFFLLYFSFPLNFFLFAEFTSSFLTNFISIFFLYSFNFNLISTFFLFVFLSFFLFLFLSFFLSLSYFLSFFLFFFLSFCFSFFLSFCFSFFLFFFFSFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EUI4</accession>
    <name>A0A812EUI4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_80150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005591">
        <property type="protein sequence ID" value="CAE1330887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EUI4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1330887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="367" mass="43892" checksum="5507071F25461BB6" modified="2021-09-29" version="1">MVSSIPIYLSIYLSIYLSIYLSIYLSICPILFISIYLSICRTNPFFSYLSIYQSIYLSIYLSIYLSIYLSIYLSIHLTLSYIYIYIYIYIYIYIYIYIQFFSYLSIYLSIYLSIDPSIDLTHSFHIYLSLYISTQFLLYPILFISIYLSIYLSIYLSIYLSIYLSSPFFSYLSLYISICPILFMSIYLSIYLSIYLSIYPILFISIYLSICRTNPFFSYLSIYLSIYLSIYLSIYLSIYLSVLFLFLFSFFFSLLSLSPSCCFLLLSFASFLTSLFSSFFIFLSFLFFSFLSNSNISFDYFSSPHFFFFTFPTFILSFFLSFFHFTFFLSFRFLSVFLFPYFYFTFPSSYFFLSLSSFNFYIPSLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EV97</accession>
    <name>A0A812EV97_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_79988</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005587">
        <property type="protein sequence ID" value="CAE1330723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EV97"/>
    <dbReference type="OrthoDB" id="6159605at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="248"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1330723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="469" mass="52007" checksum="7B6CF6569895B175" modified="2021-09-29" version="1">MTLRIPPMCPWASQFNDVNSSKNVHDFYSPKTLQIDNDLQEITSNAATNDFFTTIEAECLQPLEPNRSPAHENKPDISLSIEDKSNFSSTITNKNLNSLDFYGPSPLSSEFLLQSSMNNNDLHSTLFSSATENQINHELAQTEAEIRRRTFLMSEHYNRKTRREVQKDMLASSLCSQTFQMNSQAHPTDDFHQNLQIQAKKNLPTGDRNVAKTIRKAVDTPTHSYVIHKHQGSMLSNMADLWKKGKLCDATIGNGTMKIMVHKIVLVALSPQLLSLPNTDLTSGCFQLTFPQEIGGDALWAFAKYMYEGVVSLNVDVLEDMERISKILNLQDLQDMCSLYRNQVNLPNNTSLSQASIVNNSSTTDIAINLDPLQPSVTSAPTSSGVSFFSLPSGDITQTVSRPVQHLQILSTSSNDHQLPYSSNQSPTPGLKLSPEERSCVTISPSDSDSDYTIVTSNVKQEPSSPDGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EX00</accession>
    <name>A0A812EX00_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_80907</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005613">
        <property type="protein sequence ID" value="CAE1331773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EX00"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="280"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1331773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="339" mass="39094" checksum="1DDE46466693F2AD" modified="2021-09-29" version="1">MLSPVCLTQFRCPNVSRFQLLQKYLWFLFITDFELISLPPFLTLPLSLNLLLSTFLHILLSIPFSQCSFFFPPLSVPFSLPTFSIFLLSFSVPYSHILLSQFLTLPLSLNLLFSTFHHFLHTLSLYFTLYSFHSMFLSLSSSSCSLLSPFFFCPLLSLLTLSVSFSPFSVSLFLSLSLLYPFSFLFFLSSFSMYTSLHFPSLFSIPFSLHLLRFLSSLLLPFFFLSFSLFLLFPFLFLSHFFLSIVFSFSSLSNSCFLSLSLSFFLSFSKAALILSPVSLSIYLFKYLCLFLFFFFLSRRYNSSSLYLSLSSFLKSRFLSSFFLEGWAHLLSISLCLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AIN2</accession>
    <name>A0A812AIN2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_119</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000001">
        <property type="protein sequence ID" value="CAE1137421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AIN2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="350"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1137421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="440" mass="48511" checksum="57E7DAAAF8099385" modified="2021-09-29" version="1">MALSFARRAHYVAKRKNDNVLSLIYPISSVLLYSNNSIINFSSSQIHFLAHGHHSLNRLSLPSLFFSISFKSVLASDFSVFSFPSCNLDIFSDIFLSFRFCSSICVFSFHTYYFRLTFFPPTENSIPECYVFAYFWGFFFSHLLSLSLSLSLSLSLSLSHLISSLSYLLSFSLSVISSPFSLSFSLILSPFSLSSPFSLSLSLFLSLSLFLSLSLITSTFSHISFLFLSLLSHLLSLSLFPSNLIAFLSLSSPFFLSFSLSFSFLSVSFLSPHLLSFSPPFTLSPSSLSSFLFPPFSLPPPFSLPPPFSLSLSHYPPFFLTLSVSIFLSLLLFLSLLLSLSPPFSLSLSVLFSLSLLLSLFLSAPFSLSASSFVFLLPLSAPFSLNSFPSLSQFLSLSASFPPSLSPSASPLSLSLCSILPDLYSPSPSFLLLYLYSSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AKF6</accession>
    <name>A0A812AKF6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_762</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000020">
        <property type="protein sequence ID" value="CAE1141104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AKF6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1141104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="237" mass="26353" checksum="D717C1B3C5F5382D" modified="2021-09-29" version="1">MYVITGRIYPSIGFFLRHFLSGFLLGYFFSSDSSSVISFSLDASVSSDSSSSGSSSDTSSTDSSFFKSSSVTSLYFSSFLDSSSDTPSNTSSNTFSSDSSFLESSSVTYSDSSLYTSFSYFTFSDSHTFSLSSSLDSFSLDSSCLYSSSHYYFLESFSSFLFLFSFSLLNFLGRNVRLLSAPFVDIFVIVVTHSIFMPLFPFLSPKQKPIQLIYLFIYLSIYLSIYLSIYLTLLVGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ANB2</accession>
    <name>A0A812ANB2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_2173</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000061">
        <property type="protein sequence ID" value="CAE1147574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ANB2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1147574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="261" mass="31541" checksum="EBA78D44053F5D35" modified="2021-09-29" version="1">MPMLKPFLEFTKNVFWQPSRLLHHFLSFFFSFFHSFLSSHFLFLSFFISFFLSFFLSFFLSFLFGHFLFSFFFLSFFPSYPAIFFLSLFFLSFFLSFFLSFFLSYPAIFFFLSFFLSFFLSFFLSFFLSFLSSHFLFSFFLSFFLSFFLSFFPIQPFSFFLSFFHSYPAILFILFFLSFFLSFFFVVIIYRHLCGLFNADKIFIAGNIFYLSIYLSIYLSIYLSIYLSLLSIYLSIYLSIYLIIISLCSYLSIYLSQYILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AQZ0</accession>
    <name>A0A812AQZ0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_3951</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000120">
        <property type="protein sequence ID" value="CAE1153568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AQZ0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1153568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="226" mass="25947" checksum="8C5137C721FD5AD5" modified="2021-09-29" version="1">MLYLFLSPILPFYLLFLFPPFYLLFLFPPFIFSLIFFQLFSNVPFSFIFFLLSSIPHILPLSVSFIFFLSPHSSSTSVSFFLNCPILLPLLSFIHFLLFLSSSLSPTLSCLYSFCLPISFSLIFVLYILFSFIFFLSPYCSFSCPFLVPLFILLSSSMSFLYSSFLPIPLFCIFFLYVLLSLIFFLSPPLLLLLSLSSSSSLSSFSSFPISPPPFHLNHNLSFKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AU32</accession>
    <name>A0A812AU32_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="18">DNAH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">SPHA_5470</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000181">
        <property type="protein sequence ID" value="CAE1158022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AU32"/>
    <dbReference type="OrthoDB" id="286107at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005858">
        <property type="term" value="C:axonemal dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.20:FF:000004">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002141">
        <property type="entry name" value="Dynein heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024317">
        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532:SF4">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532">
        <property type="entry name" value="MALE FERTILITY FACTOR KL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12780">
        <property type="entry name" value="AAA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0969">Cilium</keyword>
    <keyword evidence="8 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0243">Dynein</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="646"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="674"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain AAA module D4" evidence="17">
        <location>
            <begin position="60"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain coiled coil stalk" evidence="16">
        <location>
            <begin position="336"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="565"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF12777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF12780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CAE1158022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="693" mass="78390" checksum="06208209E1AA72AD" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AY63</accession>
    <name>A0A812AY63_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_9227</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000294">
        <property type="protein sequence ID" value="CAE1166989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AY63"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1166989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="262" mass="32407" checksum="84432E655ECCD5DB" modified="2021-09-29" version="1">MLISNHCLFLSLILSFFLFHSSLFIYLFNLQFHDIFISRLQFLSLVSYFHILFLSFFLSFFLSFFQELINSLFLRFINSFFLSFKNSVILYFLHLSILSFFPSFFLSFKNSLILYFFHLSCFFFFFPFSFFFFFLSFFSFFFFLQELIFFISSIFNFFFLSFFFLSFSFLFFFLFLFINSFYFFHLSILSFFLSFFFLSFFLSFFQELIISLFLPFINSFFLSFFFFLSFFISFFQELINSLFLPFINSFFLFSFFLSFSRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B0D5</accession>
    <name>A0A812B0D5_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_9071</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000291">
        <property type="protein sequence ID" value="CAE1166797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B0D5"/>
    <dbReference type="OrthoDB" id="6241411at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF20">
        <property type="entry name" value="REVERSE TRANSCRIPTASE-LIKE PROTEIN WITH RNA-DIRECTED DNA POLYMERASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1166797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="244" mass="28369" checksum="995C7D8868648A0D" modified="2021-09-29" version="1">MPLRQRLLAEPMQQNPDGCRQWRRMSHVRQHQNRHRRHSHQDGSAEVQGRRASRRESLCLRRLANPAVFVFLVYPESQCGFRAGRSTVDMIFSLRQLQEKCREQQKPLFIAFIDITKAFDLGLGQNKRTLQPPGEQGRMSAKTAPDGQVLPRGHAQHSLLQWRDIRRLPCEQRRKAGLCPRADTLWDLLLHASPVRLLRLHARIYTRTRADGKLYVYVREVLIRVMLFADDAALTSHTEDSPQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B1V3</accession>
    <name>A0A812B1V3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_9294</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000297">
        <property type="protein sequence ID" value="CAE1167206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B1V3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039715">
        <property type="entry name" value="ZCCHC10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13491">
        <property type="entry name" value="ZCCHC10 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13491:SF0">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="348"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="389"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="438"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="490"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="533"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="568"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="595"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="628"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="666"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="699"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="732"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="771"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="823"/>
            <end position="841"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1167206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="843" mass="97254" checksum="4B47E8D182577411" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B3V3</accession>
    <name>A0A812B3V3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_12364</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000414">
        <property type="protein sequence ID" value="CAE1172995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B3V3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1172995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="201" mass="25380" checksum="A30A669190835A10" modified="2021-09-29" version="1">MVLFRWFHIFSIFFTFFIFFPFFIFFTFSFSFFIFFLSSFFSLSSFSFFLHFLHFLHFLSFFIFSFFTFFIFFIFFTFFILFISSFSFFLIFFHFVHFLHFLHFLHFFIFFTFFIFFAFFTFTFFILCRNSSFIFFKFFSLNLFPELFSFIRISFFPLNLFSGLFFILFVSFILFPILGIFRYVLFFCSRFLHFCPLYIHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B4Q0</accession>
    <name>A0A812B4Q0_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SPHA_10203</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000329">
        <property type="protein sequence ID" value="CAE1168735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B4Q0"/>
    <dbReference type="OrthoDB" id="10006996at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050839">
        <property type="term" value="F:cell adhesion molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051275">
        <property type="entry name" value="Cell_adhesion_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640:SF31">
        <property type="entry name" value="IRREGULAR CHIASM C-ROUGHEST PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640">
        <property type="entry name" value="NEPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="2 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="456"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="110"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAE1168735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="590" mass="66442" checksum="29A4047A00450DC3" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B5Y9</accession>
    <name>A0A812B5Y9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DENND5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_13531</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000457">
        <property type="protein sequence ID" value="CAE1175281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B5Y9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1175281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="224" mass="26071" checksum="8C50CF08999B46FC" modified="2021-09-29" version="1">MSFYRRIEIHRCIKRPKTENLYSCYGFFIIYLSIYLSIYLSIYLSISFTPDLSIYLFAFRSVFFIVFRFISACSHLSIYLSIPVLFRLPLPLSFSIYLSMPVFPIPLPPPSLSLSLYLSIYLSIYLSIYLSIYLSLFISIYLSIYLSIYLSIYLSIYLSIYPSFYSPSPTIPLVLSIYLSIYLSIYLSIYLSIYLSQFSSLSLSLSLSLYLSIYLCISSLLKVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BAU7</accession>
    <name>A0A812BAU7_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zinc finger CCHC domain-containing protein 7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">TRAMP-like complex RNA-binding factor ZCCHC7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SPHA_13257</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000444">
        <property type="protein sequence ID" value="CAE1174761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BAU7"/>
    <dbReference type="OrthoDB" id="5592120at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031499">
        <property type="term" value="C:TRAMP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071031">
        <property type="term" value="P:nuclear mRNA surveillance of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071039">
        <property type="term" value="P:nuclear polyadenylation-dependent CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071036">
        <property type="term" value="P:nuclear polyadenylation-dependent snoRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071037">
        <property type="term" value="P:nuclear polyadenylation-dependent snRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051644">
        <property type="entry name" value="TRAMP_AT-DNA-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46543">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46543:SF1">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="11">
        <location>
            <begin position="124"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="11">
        <location>
            <begin position="145"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="11">
        <location>
            <begin position="163"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="11">
        <location>
            <begin position="186"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="11">
        <location>
            <begin position="228"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="300"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAE1174761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="353" mass="41412" checksum="8ED400BDEED0C6D2" modified="2021-09-29" version="1">MLFFRSSATKEFELRSFVSSCFLVRVKRGIKMWAYNDNLYEREDDDDWVYPPSPDTDEEQQEEEDWKEIEVELFSQLHYNSKQLDGASASENPPNTLDEGDPMRVIRRPLLRNTDVRATRAYHCDNCNEVGHLSRDCNQKSREICILCGEFGHLRQQCPYIFCYNCKLPGHRFAECPSTKNSYVTCYRCQMFGHIQPNCPDLWRRYRYTTTRGPLVTSNCIANTRIYCYNCGEKGHYGFECMKDPMNPFVYSRYPFVVNYDSCWANTENESKRRKIEPDTSGYTFNIPDAMKNVIGFSKSTRKRKRGSKPAEDSNAYFISSESKKKNKSKRTKMQRFRCAAKRRMASAIRKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BBC4</accession>
    <name>A0A812BBC4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_13668</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000458">
        <property type="protein sequence ID" value="CAE1175373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BBC4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="334"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="367"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="419"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="450"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1175373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="480" mass="56145" checksum="A14D2F0609962A75" modified="2021-09-29" version="1">MKLKKRCGLFLCLLRILSRVFLSACSTPRQCSASHCFFVSFFLFLSFFVNYYHFHFLGFFSFLFFYLYFSVLLLLSFSSFVFLLSFFFFFFLLFFLSRTYLYFFLGFLLACFLFIFKARKTILLHQPLSKRRCFFSSFLPSFLPSFLSFFLFHSFLLSFFLSFFVFLLTFVISLLYFCFLSFFLSCLLAFFLSFFLSCLLSFLLACLLSCLLAFFLSFFLSSLLSFFLSFLLACFLSFLLACLLSFFLPCLLAFFLSCLIAFFLSFFLSFFLSFMPAFFLACLLACFLPCLLSFFLSFFLVCFLSFFLSFFLSFLLAFFLSFFLSFFLSSLLSFFLSFFLACLLSFFLACLLSFFLACFLSFFLSSLLFSFFLFFLSFFLSFFLACLVSCLLACFLSCLLACFLSSLLAFFLPCLLAFFLAFFLSFFLACLLSFFLACLLAFFLACFLSFFLSFLLACLPAFFLSCLLACFLFIFKARKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BBU7</accession>
    <name>A0A812BBU7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_14490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000495">
        <property type="protein sequence ID" value="CAE1177132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BBU7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1177132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="151" mass="15917" checksum="1A23CBC1B617C109" modified="2021-09-29" version="1">MSICSNISFHSLFTFVTASPPFSLLLLSLSSSSPLSLPPYSSLLLPTLLSPPLLSLLLPPSLLLPPLSSSLLSSLLLPTLLSPPPSSSLSSSLSSPLLLLSSSSLLLPPLLLPPPSSPPLLSPPPPSVYVSKQHLCFHRSNFSDSYLIQKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BHF2</accession>
    <name>A0A812BHF2_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein FAM184A/B N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SPHA_16723</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000593">
        <property type="protein sequence ID" value="CAE1228260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BHF2"/>
    <dbReference type="OrthoDB" id="75801at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039478">
        <property type="entry name" value="FAM184A/B_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18870">
        <property type="entry name" value="PROTEIN TAG-278-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18870:SF9">
        <property type="entry name" value="PROTEIN TAG-278-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15665">
        <property type="entry name" value="FAM184"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein FAM184A/B N-terminal" evidence="3">
        <location>
            <begin position="96"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="97"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="204"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="312"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAE1228260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="658" mass="76967" checksum="5D7E62883B8A9DF5" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BI65</accession>
    <name>A0A812BI65_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_18003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000646">
        <property type="protein sequence ID" value="CAE1231100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BI65"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="280"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1231100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="309" mass="37782" checksum="33D4DA079B5D61CA" modified="2021-09-29" version="1">MAAVVRNQGQIHLFLFATFYFFFFLFNISFLIFSFSFFSFSASVSLLCPIIYLFNVFFLTISPVFLPNFLSLLLIYFYRLFLILFPFSFILFPFPFSFILFPFPFSFILFPFPFSFILFPFPFSFILFPFPFSFILFPFPFSFILFPFPFSFILFPFSFFFYSFSFPFFFIFSFSFSFYSFSFSFYSFSFSFYSFSFSFSFFFYSFSFSFFSFSFILFLLFFFFYSFSFIPFLLFLFLFLLFLFPFSFISFSFSFFYSFFSLTLCHLFFSHSSSFFSLSLISSFTFFFPFFLWLMFMYSFISFYKSFLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BKY8</accession>
    <name>A0A812BKY8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_22351</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000825">
        <property type="protein sequence ID" value="CAE1240489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BKY8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="293"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="327"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1240489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="350" mass="40494" checksum="FE42D9B3074D00B6" modified="2021-09-29" version="1">MQQTDEEGCMSHQMQQTDEEGCMSHQMQQTDEEGCMSHQMQQTDEEGCMSHQMQQTDEEGCTNHQHIFVCFLYFPTIYIFIIFFLFHNCFPLFIPPPLSLISLLIFLFPLTLLSLLLIFLFPLPSLSFYSPLPSSFLLPLPSFCLSYPSPSYLSFCLFYPLSLIIFLLPSSFYSPPLLLLILLFLSLILLYFIPSPLIIFLLPSPLIFFTPSPLLLLILSPLPLLSLILLIFLFPLPSLSFYSPHLFYSLSPPFAYLIPSPLLTLILLIFYSLSPHYLFPPLPSSFFTPSPLLFFYLIPLSYPHFAYLFIIPHYLFFYPSPSFCLSYPLSLSYLPFCLSFYPHSLFYLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BLB1</accession>
    <name>A0A812BLB1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_18853</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000680">
        <property type="protein sequence ID" value="CAE1233071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BLB1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1233071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="230" mass="27869" checksum="4C6C77DCE5C9F2A5" modified="2021-09-29" version="1">MVSFSFLPHLFSIFLSFSIFPLLFSFFSHFLYFSIFYFFLSFTSHFCLSFISHFFLSFFFLSFFPIFSFFSLFFLFYFQFLSFFFFLFISHFCLSFIFHFCFSFISHFFFFIFFSILFLISVSLLLSITSFLFRSIYLSIYLSIYLSIYLSIYFLVISSSLSLFQFLSIYLSMFVHYLSIYLSIYLSIYLSISVCSHLSLCMSVYLSIYLHYLSIDRSTKREREIVKKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BLF1</accession>
    <name>A0A812BLF1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_18872</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000681">
        <property type="protein sequence ID" value="CAE1233205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BLF1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="366"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="390"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="416"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="448"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="504"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="536"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1233205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="559" mass="67356" checksum="0A35742210C86852" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BML9</accession>
    <name>A0A812BML9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_19439</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000705">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAE1234584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="413" mass="51159" checksum="323734CE5EB2975D" modified="2021-09-29" version="1">MPFFFSFFFIFPFFSFLFLFFSFSFLFFISFSFYLSFLYFSFLFLFFSFRFLILFCLSFSLFFLSFLFLFFSLSHSLFAFFFFFFPFFSFFFFSFFSFSFAFLFFYFSFLFFFFLFFFSFSFAFLFSLFFLSFLFLFFSFSHSLLPFFFLYFSFLFFFFSFLYLILFCLSFFFIFPFFSFSFLFVFSFSFAFLFSLFFLSFLFLFFSLSHSLLPFFFLYFSFLFFFFSFLFLNLFCLSSSSSSSSSSSHFTFALFIFLKFFFIFLFFYLFIFLFVCFVFLPVFSFTFLFHFPSFFFFFFFFYSYLSFLLLFFCFSLSLFAFFFPLSLFLSFLFSILFCLSFSYSLLSLSFSFFPFFLFLYLYLSFFHFVFPVFFFLVQFIFSFSSSITSIKILFLHTPSMLCYEGKKKREEIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BNW1</accession>
    <name>A0A812BNW1_ACAPH</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_20156</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
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            <taxon>Decapodiformes</taxon>
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            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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            <end position="236"/>
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    </feature>
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            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAE1236226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="245" mass="28292" checksum="EC7DEC8BBF4470AB" modified="2021-09-29" version="1">MKTKKSRVRTPSALSGPSVRRTGQLETHTSKTIAAPIFFFFSFSSFSSSSFFFFLFFSDLLLLLRSSPSPSPPPSSPIFFFFFSSSSFSSSFFFFFFFFFFSFFSFFFFSFSSFSSSSFFFFFFFTNLLLLLLLLFLLRSSPSPPSPPFSSSFSSLNFLLFSSFFFFSSPSSSFFFFFFSSSFSFFFFFFFFSDRLLLLRYSSPFPPPPPPSSSLIFSFSFSSSFFFSDLFLLLFVSTSNLPISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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            <strain evidence="3">Farmed</strain>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="336"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="366"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="392"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="416"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="445"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1238552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="483" mass="56555" checksum="D8D74537DD21097B" modified="2021-09-29" version="1">MPASTHFLLTVRDDITLLPVEIWQSIQILNLLLYIKQFVFTSLHNVRYFISISIYLSIYLSIYLSIYHAFVHDYESLCFSICIYLCTYLSILIFFISIYLSVYLSQSVSIYLSIYLSIYLSIYLSIYLSIYLSMSACRIKHSLFISIYLCALSIYLSIYLSIYLSIYLSIYLSIYLSIYLSIYSNISVKHFSENICLLSKSRFRNCHGKSSKNNSKYPDLSIYLSIYLSIYLSIYLSLPHFPLLKNLRQLLFYYYIFVFDIVLNFNFFSPDTIFLVFFPAQFYFLFPHCLIFLLSLFSLSLSLSLSLSLSLSLSLFLSSLFSLLSLPEFFLFYLKFFFFFFSLFFLFCFFFFFSLFFSFFSFSLSLSVLLFSFTLFLSQYFFFFLSLSLSQFFLFLSVFLLFLLSLPQFLFFLFPLFSRSYCSLSFFFIALLFLSHIRPPSIPPPSTPLPSTPPPSTSLLSTPPSTPLPSIPPPSTPPLLLFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BRR6</accession>
    <name>A0A812BRR6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_25658</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000970">
        <property type="protein sequence ID" value="CAE1247388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BRR6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1247388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="219" mass="25463" checksum="9C8861C98B95055E" modified="2021-09-29" version="1">MLKIHSLFLTTYSLEVIYFRLIYLSIYLSIYLSIYLSIYLRVFISIYLSMSVFYLSIYLSILACSYLSQTFHIYLSYSVHISLSLSLSLYLSICLSSPVHIYLSLFVSIYLSIYLSIYLSQFINIYLSLFISISTFSYLSVYLSRFISLSLTLSIPLSIYLSQSVHIYLSIYLSIYLSIYLSILSIYLSIYLSIYLSIAVCSLSIYLSIYLSIYLSIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BST0</accession>
    <name>A0A812BST0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_22305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000824">
        <property type="protein sequence ID" value="CAE1240386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BST0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1240386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="269" mass="31548" checksum="5E7BDC9D4E7EF122" modified="2021-09-29" version="1">MTFVCQSAFSFFASFFLRLFTFLSLSQLFSFFFHLSICNSFFLSFFLSFFLMLFTSLYPLLSFFLSFFLSFFLSLFTSLYVIQPLFSFFLSFIHSFFLSYAVHLSICNSDSPFFLSFFLSFAVHLSICNSASSFFLSFFLLLFTSLYVIQPLLSFFLSFFLSFAVHLSICNSASSFFLYLAIHIYLSIYLSIYLSIYISPTTPLFLSLSLSNLLIFLSFFLSFFLSFFPFLYFRSHCSCCRPFSFRQNVEELGGNYFHSRNHYTSKDLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BTS3</accession>
    <name>A0A812BTS3_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">nitric-oxide synthase (NADPH)</fullName>
            <ecNumber evidence="4">1.14.13.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SPHA_21590</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Farmed</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NOS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.39" evidence="4"/>
    <dbReference type="EMBL" id="CAHIKZ030000792">
        <property type="protein sequence ID" value="CAE1238965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BTS3"/>
    <dbReference type="OrthoDB" id="1688044at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004517">
        <property type="term" value="F:nitric-oxide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006809">
        <property type="term" value="P:nitric oxide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.340.10">
        <property type="entry name" value="Nitric Oxide Synthase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1230.10">
        <property type="entry name" value="Nitric Oxide Synthase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.440.10">
        <property type="entry name" value="Nitric Oxide Synthase,Heme Domain,Chain A domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050607">
        <property type="entry name" value="NOS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044943">
        <property type="entry name" value="NOS_dom_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044940">
        <property type="entry name" value="NOS_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044944">
        <property type="entry name" value="NOS_dom_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004030">
        <property type="entry name" value="NOS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036119">
        <property type="entry name" value="NOS_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43410:SF1">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43410">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02898">
        <property type="entry name" value="NO_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56512">
        <property type="entry name" value="Nitric oxide (NO) synthase oxygenase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0288">FMN</keyword>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="10 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="355"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="400"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="Flavodoxin-like" evidence="13">
        <location>
            <begin position="278"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAE1238965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="425" mass="49725" checksum="E2CCB8A609411FE2" modified="2021-09-29" version="1">MFSSLLLSIYLSIYLSIYLSIYLSQKLLIYLSIYLSIYLSIKRLSNGQDPELYELPEDLILEVLLEHPKYTWFKELGLRWYVVAGISNMLFDCGGLEFTAAPFTGWLMDTEVGTRNLCDTQRYNIVPMIAEKMGLDVKKNSSQWREKAVLEVNIAILHSYNKTNMTMTDHYTAAEAFHQHWEKEYQVRNGCPADWVWIIPPIGGSLMSVFHQEMLYYRLKPSMEYQQNIIKIHKWKKPENIAIFTRERRWDVTFSVLAKAVFFTSIIYRMILQQRIPCTILYASETGTAQLFAEKLARNFRLAFNTKVICMDSYDIKNIPSEKLLLVVASTFGSVFTSINSSFFPPLSLSLSLYLSIYLSIYLSLYIYFTAHWVFGTILRNYRPPEEHKKFKCGQDFRNVRYVIKSFILFYFSILLNDAKLLSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BWQ2</accession>
    <name>A0A812BWQ2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_24376</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000908">
        <property type="protein sequence ID" value="CAE1244624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BWQ2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="342"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="376"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="408"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1244624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="430" mass="49908" checksum="A68725F9B7952650" modified="2021-09-29" version="1">MVVSTNLNSLSLCYPHFTRYHCQYFSARFISIGHFSLLLASTEAFTIHGRNRYRCQALLSFHLEISTPQYHAVPPFILSPYSPYRRSQFSLFFLNLFQSSFLLLILFTFSFIPHPHSPCSPLSLLNIFTALFLFAFLSVFSLFTLSFFLNQFTLPFIHFKLSFIRFFNLDLSFLFLSSLFTIFLIFFTLISSFSPYSPFYSPCSPVYSSYSLFLILTLLFLYLLSTYSLFSYYIIYSPLILFLFLSLFNFYLESFPSSYSHISPTIRPPPLFLVILLILSLSFSLLICHFSFCFLHYSCSSFTAIAFLLRHFPFSFVLVHSTFIFSIYCFYLYSLYHLCAPLLLFLVLPSLLLSSFLVSSLASSCPARSNFSPYSIFHYVFFSSLILSSFCIFLPFSLSLSLSLSLSLLYLFTLSANLIYLIFFCSLLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BYF6</accession>
    <name>A0A812BYF6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_25211</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000954">
        <property type="protein sequence ID" value="CAE1246575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BYF6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1246575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="225" mass="25424" checksum="F92BB47D02677FA4" modified="2021-09-29" version="1">MSGEDSIFLFSVNGVLYISYISSQASIYLSISLLLSLSLYLSQSLHYLSITIFSLSNSLSQYVHYLYIYLSIYLNTSDHFLSIFYSDLKGLSLHVSLSFFFFSFFLSFFLLNNPVSISFSSPSSFYLSLFIYLSIYLSIYLSIYLSQIFILSFSSGILDHCLSHFNNYSLAPHTHTLSFSLITIALKHIRIIDSPSSLFSSSLILVSPNHSPSSSSHIKYHSPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BZ15</accession>
    <name>A0A812BZ15_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">IBA57</fullName>
            <ecNumber evidence="4">2.1.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SPHA_25549</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.-.-" evidence="4"/>
    <dbReference type="EMBL" id="CAHIKZ030000967">
        <property type="protein sequence ID" value="CAE1247183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BZ15"/>
    <dbReference type="OrthoDB" id="191995at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017703">
        <property type="entry name" value="YgfZ/GCV_T_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045179">
        <property type="entry name" value="YgfZ/GcvT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03317">
        <property type="entry name" value="ygfZ_signature"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22602">
        <property type="entry name" value="TRANSFERASE CAF17, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22602:SF0">
        <property type="entry name" value="TRANSFERASE CAF17, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103025">
        <property type="entry name" value="Folate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAE1247183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="220" mass="25267" checksum="36FF7BE1F73483E0" modified="2021-09-29" version="1">MILNVQGRVLYDIILYAVPTQREGEDHFYLECDTNVSADIVKFLKRYKIRKKVIITDLEGEFRTWASLSSPQQIQNSLSEKETRKITLCEQDPRVPSFGSRLILPHDTSFLSGNERDYHLKRYQLGIGEGIEDLPPGNCYPLECNLHFKHGVSFQKGCYIGQELTARTHHRGVVRKRLMPIFFESIPEGLNSGEIITDTEDKTFSVLIANAYFLPFLPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BZB5</accession>
    <name>A0A812BZB5_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SPHA_29658</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001184">
        <property type="protein sequence ID" value="CAE1255533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BZB5"/>
    <dbReference type="OrthoDB" id="6162606at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1460.10">
        <property type="entry name" value="GTF2I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004212">
        <property type="entry name" value="GTF2I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036647">
        <property type="entry name" value="GTF2I-like_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46304">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR II-I REPEAT DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46304:SF1">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR II-I REPEAT DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02946">
        <property type="entry name" value="GTF2I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117773">
        <property type="entry name" value="GTF2I-like repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51139">
        <property type="entry name" value="GTF2I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Chromo" evidence="8">
        <location>
            <begin position="751"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="229"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="465"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="636"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="48"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="95"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="141"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="229"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="252"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="284"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="315"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="688"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="708"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="734"/>
            <end position="746"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAE1255533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="791" mass="86231" checksum="ADBA43FB3D4EB864" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C050</accession>
    <name>A0A812C050_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="15">MAPK4_6</fullName>
            <ecNumber evidence="15">2.7.11.24</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SPHA_27259</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Autophagosome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="15"/>
    <dbReference type="EMBL" id="CAHIKZ030001050">
        <property type="protein sequence ID" value="CAE1250771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C050"/>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000624">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000281">
        <property type="entry name" value="Mitogen-activated protein kinase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008350">
        <property type="entry name" value="MAPK_ERK3/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01771">
        <property type="entry name" value="ERK3ERK4MAPK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="10"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="136"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="730"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="730"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAE1250771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="768" mass="87638" checksum="5C0C4B0D9F54C787" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C0L2</accession>
    <name>A0A812C0L2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SPHA_26116</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000999">
        <property type="protein sequence ID" value="CAE1248356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C0L2"/>
    <dbReference type="OrthoDB" id="10251155at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053998">
        <property type="entry name" value="ACDH-11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052904">
        <property type="entry name" value="Acyl-CoA_dehydrogenase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42707:SF2">
        <property type="entry name" value="ACD11 DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42707">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22217">
        <property type="entry name" value="ACDH-11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032496627" evidence="1">
        <location>
            <begin position="16"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="2">
        <location>
            <begin position="58"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase 11-like C-terminal" evidence="3">
        <location>
            <begin position="114"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAE1248356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="221" mass="24778" checksum="02517DA8FEED03D4" modified="2021-09-29" version="1">MAKLLLFSSASGLYSCPLAMTDGAAKIAEMHQEDNLHLKKAFTHLTSRNPIEFWTSGQWMTERQGGSDVAASTETIAKKEDEEDFYRLFGNKWFTSATDANIAFTLAHIVGKDGQLLQTLNAAVSNPHFLVPGARDFAFSIARIYICALLINHASSSEATESDIMTAFYWSRVNLTPFVDGINRCTYDQKYCKAEYDIVFNNLTPKTMEMMAKVEKKKNCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C4A4</accession>
    <name>A0A812C4A4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_27504</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001068">
        <property type="protein sequence ID" value="CAE1251272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C4A4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1251272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="288" mass="34769" checksum="7D3E5212B7EE3114" modified="2021-09-29" version="1">MTLYLNLFTTICVSSYLSIYLSIYLSIYLSHLFTYIYLFIYISESVHYLSIYLSIYVYSYVSMTVNFLYLSFSYLSIYLSIYLSIYLYLIIYIYLFIHLSLFIFIYLCIYDYLLIYSLSFYLSLFIIYPSLFIIYLSIYLSIYLSIYLSIYHRLFISIYLSIYLSQTVNIYLSIYLSIYLSIYHRLLISIYLSIYHRLLISIYLSIYLSIYLSIYLSQTVNIYLSIYLSIYLSINHRLLISIYLSIYLSIYLSIYLSIYHRLLISIYLSIYLSIYLSIYLTFFQLSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C718</accession>
    <name>A0A812C718_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_28140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001110">
        <property type="protein sequence ID" value="CAE1252834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C718"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1252834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="368" mass="41078" checksum="B9CF7D121157D521" modified="2021-09-29" version="1">MSHSTRNISFQIVDAFSGANLYTIRNALTLELAPICNTMLIKEVYLRSLHSNVPTPPRSSLHNSLSSGLPPSHLSQRTPTNLHTPKFSSRQSSRLRDRISISSTHRNGGVSFFGPITALHARHKRTLLCRELSLITPVAANSCQSPPAVPRNVALATAPITYDPTTGAGPLKRSIITRRGLCSGDYRFSHLRAVFHHGPGPVYQDGNGLARHRLLPETLLSLTTATIQLQQLHRSLHSNVPTPPRSSLHTTLSSGLPPSHLSQRTPTNLHTPKFSSRQSSRLRDRISISSTHRNGGVSFFGPITALHARHKRTLLCRELRYLQTLTVDSWSHQYNIRTSLPTLSLHRRPFPMYIIIFHSNVSFLKRLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C802</accession>
    <name>A0A812C802_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_31768</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001313">
        <property type="protein sequence ID" value="CAE1259610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C802"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1259610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="221" mass="24589" checksum="B9A3CF7EC0FCC335" modified="2021-09-29" version="1">MPSRFSSTTHLCLFSDPFLPDLLPQSSAPLSQTSAPRSLAAVLFIEKVTVISIISLCISLSLSLFISLHLSLSLSLFRSLTVTLFRFVSGHNFLLLVLPFFPFSFKCVFIYLSPSLSLSLSLSLSLSGLHYLHRSHSLSFCSVSIYLSIYLSISLSIYLSIYLSIYLSVSNIQLVFVLAIGAMHPRPSPPPQGHSRQGWGWDSTVDNRHIQTTQKKKYGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C9E2</accession>
    <name>A0A812C9E2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_31847</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001321">
        <property type="protein sequence ID" value="CAE1259811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C9E2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1259811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="195" mass="23790" checksum="0317CA08BD110717" modified="2021-09-29" version="1">MNFCLFSFFLSFKHRLYFLNLIHSFSFPFFHSVPIQVFFFCLVIVRSFIHFFVFLFFLSFFLSFFLSNLPFLIHIFLYFYHPGYPSLVHSYFVLSFIPSFFLSFLLAYLFSFFGTPPNLTIILSYINVLSFLLSLSIYLFPFIFSSFSLVRSLVFYSIFIFLSYRLTFFVIYLFYSFFLLFFSSEFFHHMFPFFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C9P9</accession>
    <name>A0A812C9P9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_29463</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001172">
        <property type="protein sequence ID" value="CAE1255320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C9P9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="329"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="363"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="392"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="439"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="464"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="491"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="524"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="565"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="620"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1255320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="654" mass="75459" checksum="4FA35B9D7B0031ED" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CAV1</accession>
    <name>A0A812CAV1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="15">RRAGA_B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SPHA_36004</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Farmed</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Lysosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the GTR/RAG GTP-binding protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001558">
        <property type="protein sequence ID" value="CAE1268124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CAV1"/>
    <dbReference type="OrthoDB" id="10020193at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990131">
        <property type="term" value="C:Gtr1-Gtr2 GTPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010507">
        <property type="term" value="P:negative regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11384">
        <property type="entry name" value="RagA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.190:FF:000002">
        <property type="entry name" value="Ras-related GTP-binding protein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000276">
        <property type="entry name" value="Ras-related GTP-binding protein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006762">
        <property type="entry name" value="Gtr1_RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039397">
        <property type="entry name" value="RagA/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259">
        <property type="entry name" value="RAS-RELATED GTP BINDING RAG/GTR YEAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259:SF1">
        <property type="entry name" value="RAS-RELATED GTP-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04670">
        <property type="entry name" value="Gtr1_RagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 14" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="12" id="KW-0458">Lysosome</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAE1268124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="308" mass="35885" checksum="D0B61DC4D777272E" modified="2021-09-29" version="1">MKKKVLLMGKSGSGKTSMRSIIFANYIARDTRRLGATIDVEHSHIRFLGNLVLNLWDCGGQEAFMENYFASQRDNIFRNVEVLIYVFDVESRELEKDMHYYQSCLEAILQNSPEAKVFCLVHKMDLVHEEQRDSIFHEREDDLKRLSKPLQCTCFATSIWDETLYKAWSSIVYQLIPNVQQLETNLAHFANAIDAEEILLFERATFLVISYWQRKPHRDVHRFEKISNIIKQFKLSCTKVAASFQSMEVRNSHFAAFVDAFTSNTYVMVIMSDSSITSAATLLNIRNARQHFERLEKEELSRTPMVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CD38</accession>
    <name>A0A812CD38_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_37131</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001646">
        <property type="protein sequence ID" value="CAE1271098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CD38"/>
    <dbReference type="OrthoDB" id="7493852at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1271098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="213" mass="23106" checksum="871B4A988830DBBD" modified="2021-09-29" version="1">MKVSPVPEGFLGIPIPEGFLGIPRPRRLSWYPHPRMAFLVSPSQKAFLVSPSQKVFLVSPSQKAFLVSPSQNGFLGIPVPEGFLGIPVPEGFLGIPVPEGFLGIPVPEGFLGIPVPEGFLGIHVLLQSLSSSCKTHPTKELQTSSMPTCHNICHSKAAFGSMEVADLASHHRNSVNIVTSAPKNLLLERVRGCLFLQCLATFLFWQFLSSFCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CD95</accession>
    <name>A0A812CD95_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">TM2 domain-containing protein 2,TM2 domain-containing protein CG11103,TM2 domain-containing protein C02F5.13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SPHA_33755</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TM2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001418">
        <property type="protein sequence ID" value="CAE1263539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CD95"/>
    <dbReference type="OrthoDB" id="408511at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007829">
        <property type="entry name" value="TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050932">
        <property type="entry name" value="TM2D1-3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21016">
        <property type="entry name" value="BETA-AMYLOID BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21016:SF4">
        <property type="entry name" value="TM2 DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05154">
        <property type="entry name" value="TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="TM2" evidence="9">
        <location>
            <begin position="92"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAE1263539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="159" mass="17807" checksum="965E5CD5830D1265" modified="2021-09-29" version="1">MNESCGATYQPHSPLILCSYLPMEFLNCSQPQDLEENETARLLLGYGCTKWGGRRYEDVQKTAVWCTALEGVECFGNRKFLKDGFPCIKYNGHYFLTTLIYSVLLGFLGMDRFCLGHTGTAVGKLLTLGGVGIWWIVDVILLVTGSLKPEDGSNWVPYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CDZ6</accession>
    <name>A0A812CDZ6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_32454</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001353">
        <property type="protein sequence ID" value="CAE1260917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CDZ6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1260917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="159" mass="18809" checksum="B4D7016D4A822F88" modified="2021-09-29" version="1">MLMTTTDPYESTLICLPDFFLLSLSFSLFSLTFSFPQSQISFTQVAFFLKKKNLFFFLAAIYSSFTDLILVLFKILLSSISVTRCFKKPTLLFFFLAANYSSFIDLILIVFEILLSPCFFFQPHFFSCFFFFFFTLFSFRWLSLSFSLRSPLLKFLFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CFW4</accession>
    <name>A0A812CFW4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_35253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001513">
        <property type="protein sequence ID" value="CAE1266615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CFW4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1266615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="276" mass="34026" checksum="CCC9DD957E07ACFA" modified="2021-09-29" version="1">MERSLFFFFFFFLSFLNPIESFLPFFLSFFLSFFLSSFTCYLCLHFYFHSFFMYLFYSLLSCFIFLSFFFFLSFFDIFPFTFSFPFPFEHISFSFFLYFSFFLFLKFSFFFLFLSFFYLFSFCFFLFSFFGIFPFTFSFPLLFVHTSFSFFLSDVVSGLKILSFFSLFVPFFLSFFLSFFLSFKLSFFQTFFLLFLSFLSLFVSFFFLSLIYFLSLFLSLFFLCIPLFLFSFFSLFVTFFLSFFLSFFLSFKFSFFFLFLSFFSLFVCLFLSFFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CI61</accession>
    <name>A0A812CI61_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_37980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001713">
        <property type="protein sequence ID" value="CAE1273090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CI61"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1273090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="202" mass="23270" checksum="D5F49A8288A52AF3" modified="2021-09-29" version="1">MCLILERQSPPSLVISKEQSQYPCTPHCTSKKRIGIDRSILPGRSIYLSIHLSISNCSYLSRLFVSIYLSIYLSIYLKGVSISFDYLSSDHRTVKRDSRDLSIYLSIYLSIYLSIYLSISNCSYLSQSVCIYLSIYLSIYLSQTVRIYLSLFKCVSSIYLSISNCSYLSLVCFYLFYLSIYLSIYLSFELFVLSQSACIYKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CJX2</accession>
    <name>A0A812CJX2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_37344</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001667">
        <property type="protein sequence ID" value="CAE1271693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CJX2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1271693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="153" mass="18276" checksum="405E23AFCB4E63EC" modified="2021-09-29" version="1">MWKHIFIYLALYLSIYLSIYLSISGRYISIYLSIYLSIYLFCSSIYFSLFICLSIYLSIYLSIYLSISVCSYLSIYLSIYLSIYLYLSYSSQSVRIYISISFPTYLLISIYFGLCSSIYLFHWDSSILFYLSIYLSMYLTEMLTFTRIKLNFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CJX7</accession>
    <name>A0A812CJX7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_36709</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001613">
        <property type="protein sequence ID" value="CAE1269760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CJX7"/>
    <dbReference type="OrthoDB" id="9635126at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134:SF22">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134">
        <property type="entry name" value="OS08G0543275 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="325"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="353"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="385"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="413"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="446"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="481"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="510"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="549"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="576"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="609"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="662"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="693"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="719"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="843"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="869"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="896"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="945"/>
            <end position="969"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1269760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="978" mass="116831" checksum="DC67DE3C92FD6391" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CRA7</accession>
    <name>A0A812CRA7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_38631</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001763">
        <property type="protein sequence ID" value="CAE1274092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CRA7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1274092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="242" mass="26771" checksum="2D0C85C7BAF22558" modified="2021-09-29" version="1">MGLHLLVSQQHITGEVWPFLQQIVYLCLSPSYMFSPFLPLSRQPRRGNLIAMSEKRKPKVTYLWSVAPCFVSFFLLLLLPSLFLVMSLLDQYSPKTRVLSSLTWSRLDKTNLLSSFRRPWANFRKSFDHHSSRLLLHSSLLPSSSVTPAHSCSLQHSCSFQLSPAASSSAPAASSTPAASSSPQQLPAASSSPLRRSTDVPLPIPAPADDLIQRPLTSSARYRPDTVPEQTTSVVLPSTVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CRG6</accession>
    <name>A0A812CRG6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_40370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001902">
        <property type="protein sequence ID" value="CAE1276953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CRG6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1276953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="333" mass="37867" checksum="8CA61C474171BA0E" modified="2021-09-29" version="1">MKFFSSLCLVFDFESINLPSSQGLLVSSFGSSSSSVFFFFFFFFFFFCLLLLPSSSSSSSVFFSSSSSSSCSFFFFVFFFRILLVVLPSSCFFSSVFFSSSTSSFFSSVFFFRLLLLLLPSSSSSSSSVFFLRLLLLLHPSSSSSSSSSSLLSSSSVFFFFFFFFFRLLLLPSSSFPVFLFLLFRPFLLRLLLPYSFSSFLLLLLLFFFFFFFFFFFFFFFFRLVVVPSSSSVFFLLSPSSSSVVFFFFFFFCILLLFCKSATVSSLPLASCVHFASPIKIPRPLICPPQSHDSQAKIKRTKDAFYFLLPTEVFFSTPADRSPGACLSDIDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CRL6</accession>
    <name>A0A812CRL6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_43584</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002194">
        <property type="protein sequence ID" value="CAE1282632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CRL6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1282632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="219" mass="27542" checksum="8B7C7F36704B310C" modified="2021-09-29" version="1">MFFKVLSMNCNFFSHFRKFFSFFLPSFLPFFPSFLPFFLPFFFLPFFFFLSSFFISFFLFFFPFSFVFLFEFFLFFLSFFSFLSFSFFLKFFPFLNFFLLNSLFPFFSFPSFLFFSFSFFSFFPFFFFIFFLFFFSFSFCFFSFFSFFPFFLFLFSFLFSFFSFFFLPFIFIVSILSFSIPSFLFFLFSFLFSFFLLSFLNYLFYFFLPSFFLKFSFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CRN5</accession>
    <name>A0A812CRN5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_42171</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002046">
        <property type="protein sequence ID" value="CAE1280161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CRN5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1280161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="189" mass="21538" checksum="9A4BB47D41B59E9F" modified="2021-09-29" version="1">MRFRSLKTTCFPGLFVTLYCFSSYHIRIKSIYLSIYLSIYLSVCMEYSLLYVRKSIYLSIYLSHQKLQYTFSFQYFLNVYIFLYISLIFIFLRFPHLFPFLPRRQKRNFSTIRYPWGSSSSSSSSSSFFFLFLPPSPPPPPPPSSSSSSSSSSSSSSSSSSSSSNCALISSPALSLSLSISLSIYLSIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CT32</accession>
    <name>A0A812CT32_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_39652</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001857">
        <property type="protein sequence ID" value="CAE1275772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CT32"/>
    <dbReference type="OrthoDB" id="7118285at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="324"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1275772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="371" mass="40138" checksum="C478A0AFDCE6F2D6" modified="2021-09-29" version="1">MRPTSLRWHLGNALGRPSGRTGQSVTGWWAEWCDAHERINEIPTVPTYYLAKPQPRERAWNDQRGKKTLLSFPLHRRETRLCRRRKHGSRCGCGDGGLRLGGFASRRSLSASHFRFLLCRAGPTPSSVGRRFVRPGFSRPSPRPASFGVVEPEIPPLPSLPRSPGEKGDGSLGGPLASAKGAGSPPPDWGPRSTLSRGPCRAWSLTRAVRLSNGNAGVPRRAQRGRKPREAKGQKLARSRFSVRIRTAKAWPIDPFRAESSVPPRGVRKVTTGITGFWRPSVRTGTATGAVTVLRKASLFVPLGPAVADVVVARGGRVRRWRSSSATSAAVASHAATSVNGPPDLTSATGGILPSPSYFEPPVERETRGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CUT6</accession>
    <name>A0A812CUT6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_40629</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001924">
        <property type="protein sequence ID" value="CAE1277363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CUT6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1277363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="277" mass="32219" checksum="4E2975F6D56C305A" modified="2021-09-29" version="1">MYSNSSRTIYKRVSTIVSILEDSFLSIYLSIYLSIYLSIYLSILHNHYQYDLFIPIYVSFMRHFTFVQRIQSGEEIGSTKLFFYFVCMYVCTYLSICLSESVHIYLSIYLSIYLSIYLSYLNTFFSVCSSSNYQSIYLCPHLSVYLSIKLCSYLSIYLSNYLSIKLCSYLSKSVSIYLSIYLSIYKLIQKFRLFIFTSFSLHPFPIFYLSIYLSIYLSIYLSIYGNIYTLFASSLPRCTGLGSTFPAIKADATSLEIVFNSVLVPQFRSAQWSVAVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CVG8</accession>
    <name>A0A812CVG8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SPHA_40932</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001947">
        <property type="protein sequence ID" value="CAE1277907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CVG8"/>
    <dbReference type="OrthoDB" id="6285106at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031152">
        <property type="entry name" value="PLXDC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13055:SF12">
        <property type="entry name" value="LD40707P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13055">
        <property type="entry name" value="TUMOR ENDOTHELIAL MARKER 7 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAE1277907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="233" mass="26757" checksum="3AE4EA6E0890D746" modified="2021-09-29" version="1">MSLLPLEVFSTWGLSFISADGQQFVVQWHHVHLKDQNATTPFNFQALLDKSGKIKFMYKELPILPNKISSEKHPVKIGLSDAYYIDSKSNEGVIRTIYEYHRVAIDMQKIRPRTVVILEPLPTCNLAEDCRFFFNKCHKLKENEMKKCPSYSALSKKPKDSVPVAVVIVIVVVLILCISVAIWCFYGYSHPTTPLGIWMMEHRPSQMKAKMANMKFWKQSTPAGDKYRIESEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CWT4</accession>
    <name>A0A812CWT4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_41349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001979">
        <property type="protein sequence ID" value="CAE1278478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CWT4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="282"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="344"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1278478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="396" mass="46809" checksum="BDB46544B46EBFFE" modified="2021-09-29" version="1">MRIFIYLKHSLHNRIEALILEISPIASSLSLSLSLSTRTHTFKRREKLRKIFFSHLSFTKYIYLFVYLGYLSIYQSIYLCLFITIERRRSPFIYIYLSIYLSIYLSIYLSIYLSIYHSLLIYVYLSIYHSLLIYGYLSIYHNTYLSQHFLSQSIHLSIYLSIYLSHLFIYPSIYHSLFTSIYLSLSIHIYLSIYLSIYLSIYLSQSIHIYLSITSIYLSIYLSIHPSIYLSHLFIITSIIYPSIYLHPSHLSIYLSTYLSHLFTSIYLSIYPSIYLSQSIHIHLSITSIHIYLSIIHLFTSIYLSIHLSSSLFTSIYLSQSIHIYLSIYLSIYLSIYHSLFTSIYLSIYLSIYLSIYLSIYHSLFTSIYLSQSILSIYLSIYLSIYLILPTSINAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CX98</accession>
    <name>A0A812CX98_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_44946</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002309">
        <property type="protein sequence ID" value="CAE1284766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CX98"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="329"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="385"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="412"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="441"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="486"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="521"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="550"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="609"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="642"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="685"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="721"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="747"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="784"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="836"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="880"/>
            <end position="903"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1284766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="904" mass="105452" checksum="7862F485BFAE76EA" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D291</accession>
    <name>A0A812D291_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_43913</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002224">
        <property type="protein sequence ID" value="CAE1283206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D291"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23304:SF189">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23304">
        <property type="entry name" value="SPOT2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="322"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1283206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="342" mass="40091" checksum="3CAD9C206A05FC66" modified="2021-09-29" version="1">METLLTKKKKTVRLCSGARVSFSNTSVSSEEGEPLETLRWLSLDDTSDTSSSEASENDDETVEDCIGCTSFQEEFISPPLRRSARMKRRAHICSFCDEDITGEYIEGVAERRRRSPAAKRIRVIIFTNLFFFFFFFFFFFFFFFFFLLIEVCFHLPIDSFFRHLISPQILFFFIFLFFGCIFGGNSCGTFSVINASEINNKHSVVRLRFSTYLSIYLSIYLSIYLSIYLYLSLSTSIYLSIYVIYLSIYLSISVHIYLSIYLSIYLCSHLSIYLSIYLFIYLSIYIYHHLSIYLSIYLFTSIYLSIYLSISVHIYLSIYLSIYLSLFTSIYLSIYLSIYLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D4S2</accession>
    <name>A0A812D4S2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MYL6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SPHA_46106</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002412">
        <property type="protein sequence ID" value="CAE1286574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D4S2"/>
    <dbReference type="OrthoDB" id="5959761at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000003">
        <property type="entry name" value="Calmodulin A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF49">
        <property type="entry name" value="FI08416P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13405">
        <property type="entry name" value="EF-hand_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="11"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="80"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAE1286574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="211" mass="24122" checksum="C1BF35BBB23EB282" modified="2021-09-29" version="1">MAQLTEDRICDLQDIFNLFDEKGDGKISAYHLGEVLRAMGENPTQAEVKKCGYEGKEVERLSFEIVLPILQTISRNKPLVTYDDLVEGFRVFDKDQNGIVSSAEMRHLLTGLGERLSPEEADQLLQGIEDNQGNINYEELIRISKDIYLSIYLSIYLSNHKGKISIILRLYLSFFSSLFALKKNMTAFSVLMVISTNQYTSEPLSRHYPFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D4T9</accession>
    <name>A0A812D4T9_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_49939</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002908">
        <property type="protein sequence ID" value="CAE1293671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D4T9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="110"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1293671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="178" mass="20495" checksum="A9280EFF2CAF7022" modified="2021-09-29" version="1">MNSDMSLHDLINYARTTETIASHLQTMRLEDNNTATATTAPINKVADEQRQPSNYPRQYQCRNCNEKYPHERGPTSCPAFHTQCTYCGRWGHFTSVCFRRLNDGNRQWETNRPPRTQTNRRSVNRIENDQRNPHSSGSDTEYVFHTAGARNLPPPIEMDTPANRSSSLFLGLPNQIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D4V2</accession>
    <name>A0A812D4V2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_47106</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002534">
        <property type="protein sequence ID" value="CAE1288402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D4V2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1288402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="257" mass="29655" checksum="9860CB16046C35D1" modified="2021-09-29" version="1">MPTEFLSIYLSIYLSIYLSIYLSLFRYIYLCPYLSISIYFIITVKHLFLIYLSIYLSIYLSYFRSIYLSITPTSIGSWVLHAVGITVTKISLKSINLSIYLSIYLSIYLSIIILFISLSCHLSMPSCLRLFLYLSYTHIPYTSFLLLLLLLLLLLLLLLLLLLLLLLVQTGAIQSICTHILTFDYHKLGSLSRALSLFLSFYLSIYLSIYLCASAKTRWPNWCMNFLAKPRLVKETTMANDLPSILLVSDVDSRDRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D571</accession>
    <name>A0A812D571_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_47702</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002611">
        <property type="protein sequence ID" value="CAE1289565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D571"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1289565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="172" mass="21190" checksum="47BF793F982565CD" modified="2021-09-29" version="1">MFFLSFTLSFSDSFFLTFSFLFLAFRFFLFLFSLFPFSFFLSFFLSFFLSFFLSFSLFSLFLYLVSLFLFSFSLSFSFSFLSLFLFFINHAIFLFPEKLIFFTCFFFFYQFYFHFKNLSRLSYVYSVFFFSFYFSLLLYLLSLFFFTSFYSPIFFVPLRLSRPFSPFFLSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D675</accession>
    <name>A0A812D675_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_46743</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002490">
        <property type="protein sequence ID" value="CAE1287748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D675"/>
    <dbReference type="OrthoDB" id="6282070at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134:SF22">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134">
        <property type="entry name" value="OS08G0543275 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1287748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="338" mass="39419" checksum="8E1228319D337F1A" modified="2021-09-29" version="1">MALHLSLSIPSASSPRPLISVFHHLSIYLTSYLSIYLHISNFISISLSIYLSDHLTLFMSVCSHLSNCLSISFLNRLLFLLPFFLSFLSFFLSFFLSLVLSSILPFFLFSFVLSFFLSFFLSFCFLLSFFLSFFLSFFPTKTKFIEVTINFRTFFHSFIYLSISICTYHTQSVHIYLSIYLSIYLSIYLSIYLSQSFLNCLFSLSLSLSIYLSIYLSISAYLRLFICMYVCMYVSIYLSIYLSISVHMFRPISDCSYVCMYVSIYLSIYLSIYLSIYLSISVHMFRPISDCSYVCMYVSIYLSIYLSLFICVGLSQTVHMYVCMYVSIYLSIYLCSYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D8X3</accession>
    <name>A0A812D8X3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_47315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002556">
        <property type="protein sequence ID" value="CAE1288838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D8X3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="309"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1288838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="355" mass="40946" checksum="37DB770974F07301" modified="2021-09-29" version="1">MLFHIYLSIYLSIYLSIYSRSHNLLRNRLLNDYDRSTYLSIYLSIYLSIYLSNSVRSYLSISEFPYLSIYLSNSVCSYLSISEFPYLSIYLSIYLSIYLSIYLSIYPIQSVHIYLSQSFHIYLSIYLSIYLSIYPIQSVHIYLSQSFHICISIYYILVISFFLLQQEVSSSSTSSSSSPSFFSSYFSLSSSSSYFSSFSYFSLSSSSCYSSSSSFSLSFPLLFISLLLLLISLSLTLFVIPPPPLLLISLSSSSSSSSYFSLFLFLLFLLLLFFLFSLFLFFFFLFLSFPLLLLFLLLFSILLRSQIDIFLSMLVFLVVSVNFAFPRSCSNLPDHRSKFSKVFCQNHIVLRTLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DCG2</accession>
    <name>A0A812DCG2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_50174</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002933">
        <property type="protein sequence ID" value="CAE1294150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DCG2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1294150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="291" mass="33862" checksum="8E95F64A8B5812A6" modified="2021-09-29" version="1">MEQDKERIPGTGDRLKELSRTLKLSTYLLADRYLSIDRYLSIYLSIYLSTSVTLSIYLSIYLSISFNYYQSVYLCQSVHVYLSISMTQSLYLSIHLSSSLNYCVNFYLSIYLSIYLSQCVNFLSIYLSVLIFYLSIYLSIYLSIYLSQCVNFIYLSISSCLCFSPLSIYLSIFYLSIYLSHVLILSIYLSHPVCVSLLLSIYLSIYLSIYLSIYLSQCVNFYLSIYLILVLIFIYLSISSCLCFSPFIYLSIYLSIYLSIYLSISIVHIYLSIYLSIYLSIYLSIYLSVHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DCY5</accession>
    <name>A0A812DCY5_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7041 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SPHA_53876</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003443">
        <property type="protein sequence ID" value="CAE1300533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DCY5"/>
    <dbReference type="OrthoDB" id="6159822at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055469">
        <property type="entry name" value="DUF7041"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327">
        <property type="entry name" value="ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327:SF3">
        <property type="entry name" value="RNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23055">
        <property type="entry name" value="DUF7041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7041" evidence="3">
        <location>
            <begin position="9"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="169"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="204"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAE1300533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="259" mass="29550" checksum="94F2D1B0874D806B" modified="2021-09-29" version="1">MSAAVAPFPPFHEGNIKNWFLQMEAIFTVRRITDQKTKFGHVVAVLPPAIVDEVSDFLEAVPEVEPYARLKEAILRRMGRTEESLIRELFSNLTCDGRTPSQLLRYMKSRLGKNTMADSILKSLWLDRLPTTITQILAPMSENTSIDQLADAADRIFSQLDNQTMPVHSAEATRDHSSLEKTVEDLQRQVKDLTLAIESHGRSRFPSRRRFRSRPRSSSRNKDATPTMCYYHRRYGSKAHYCVKPCTYTAVAENKTASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DE74</accession>
    <name>A0A812DE74_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_51180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003086">
        <property type="protein sequence ID" value="CAE1295972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DE74"/>
    <dbReference type="OrthoDB" id="6819399at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1295972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="280" mass="33657" checksum="C72CDA246B4D0BDC" modified="2021-09-29" version="1">MNRGFISALYAYPELDRSQFIPYFLHNNSTSNFCCELTKNVTNSDRAYFFFFPPLFVLFLFSSFLCIFLFLFSLYFSFFYFLCIFFFSFPCIFLFLFSLYFSFFYFLCIFFLLFSLYFSFFYFPCIFPFRFSFENFVFTSLSTFPFFFLFFFFSFLSFFTLLFFFNSVSFFHSFFLQKKRPSLRSPLSLSLPPLSPPLSPSLSLCHPSLRPLSLSDFLVYSDELNVICSYLSIYLSKSVHIYLDLFISIYLDLFISIYLCIYLDLLFRSVHIYLDMLISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DFA8</accession>
    <name>A0A812DFA8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_53083</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003354">
        <property type="protein sequence ID" value="CAE1299225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DFA8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1299225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="166" mass="20187" checksum="7B280993792B60B6" modified="2021-09-29" version="1">MKIKTGKRVILSIYLSIYLSIYMSNFKFVSMYALKEFYSILSSYLSIYFKLSIYLSMFSSIYLSFIYLSIYFYIFYLSFLLSIIYLIIHHLFCKILSILFNFSVKYSRFKLAYCFLFIYLSIYRVYLTSYFIYLLIYSFFVLGMHIYLLLKDLSIYLSIYLYKSPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DFB3</accession>
    <name>A0A812DFB3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_54224</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003505">
        <property type="protein sequence ID" value="CAE1301093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DFB3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1301093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="313" mass="36803" checksum="7B93FC8F7A09067E" modified="2021-09-29" version="1">MSEYKCPFLGDKNASKSTSYNYTKLHWHQENLTSIKHHHFLSLIYSIYLSIYLSIYLSIYLLSLSLYIYIYPFPIYLSIYLSIYLSIYLSHICLPLSLSIYLSIYLSISYLSSLSIYLSIYLSIYLSIYLFPICLPLSISIYLSIYLSIYLSFLSFVLSFYRSTTVSSIHLAKSHICHIFFLIYLSIYLSIYLSPICLPFPYLSIYLSIYLSITYLHSPFPIYLSIYLSISYFLPYLSIYLSIYLIFAFPFPYLSIYLSIYLSSLSFFRSFVLSFYRSTTVSSIHLAKSHICLIFFLIYLSIYLSIYLSIWAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DI07</accession>
    <name>A0A812DI07_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CD63</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SPHA_54022</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003464">
        <property type="protein sequence ID" value="CAE1300727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DI07"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00259">
        <property type="entry name" value="TMFOUR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAE1300727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="181" mass="20246" checksum="7C47461A9305D2FE" modified="2021-09-29" version="1">MESAGKFVMYFTALVLFALSVILLLVGVNTFYHFSSYTSVLNYHLLSPAGVTIFFGLTLINVSFLGLLGVFCRSFLLLSLFQLLLFLLLVFEVLIGIILATLRYGTYPPIATAMLNSEERYKGNTAVARAWNEIHSHFSCCGTSQYNEWYPFFGNVCRRSPKCVAIISFFLSLSLSLSLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DI25</accession>
    <name>A0A812DI25_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_52161</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003216">
        <property type="protein sequence ID" value="CAE1297661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DI25"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1297661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="176" mass="20255" checksum="7A209C4FF45E89FE" modified="2021-09-29" version="1">MLAGIRFLSVTEKKKEHFFLFRFISIYLSIYLSIYLSIYLSQSVLSLSLFIYHSLFLLYLSIYLSIYLSIYLSIYLSQSVPCLSIYLSQSVHSLSLFIYLSQFVPSLSIYLSQYVPYLSIYLSIYLSIYLSISLFLLSLSLSLSLSLSLYLSIYLSIYLSQCVPFPSLPLSLSLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DIL3</accession>
    <name>A0A812DIL3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_53612</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003430">
        <property type="protein sequence ID" value="CAE1300096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DIL3"/>
    <dbReference type="OrthoDB" id="1668230at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032735">
        <property type="entry name" value="BROMI_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055391">
        <property type="entry name" value="BROMI_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14961">
        <property type="entry name" value="BROMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23431">
        <property type="entry name" value="BROMI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BROMI N-terminal" evidence="2">
        <location>
            <begin position="12"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="BROMI middle region" evidence="1">
        <location>
            <begin position="141"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1300096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="265" mass="29864" checksum="678A97E798AEF2E0" modified="2021-09-29" version="1">MFSLSLSLPLCRFGFVKQLKKHLDCILGPLIDDEIEKHSSEIQVNSITQQGDQTLVEKITDKIIHSKLHTEFNRRLKTNITEALEQLQKNFNAEFVVSKQNNTDYFLSCNKPDDFSDEEGSYATSFNQGSLVFICHEKLLDLCNSLAKGRDYNSRCEAMQALNQVPIAAEIICGDHWPMMRNHLFDVFSDADPQLSNLSLKFLAHAFSTANPQTKEIYSLLVDNLIHQLHTLEENGALLLKNGLSASSPEIVKIIKMVTHGGMPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DIP0</accession>
    <name>A0A812DIP0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_53695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003431">
        <property type="protein sequence ID" value="CAE1300156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DIP0"/>
    <dbReference type="OrthoDB" id="6819399at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1300156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="216" mass="25012" checksum="DEEF19562662934C" modified="2021-09-29" version="1">MLPFLPSFLPSFLPSFLPFYLSQSIHIYLSPFISIYLSQSIHIYLSIYLSISLSPFISIYLAIYLSQSIHIYLSIYLSIYLSQSIHIYLSIYLSISVHSYLSIYLSIYLSQSIHIYLSQSTHIYLSISVHSYLSQCIHTYLSIYYFSLFISIYLYQSVHIHLPIYLCLFIAISLCSYLSSYLSLFISINLSQPVHIYQAISACSYLSSYLSLFISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DK83</accession>
    <name>A0A812DK83_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_54472</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003537">
        <property type="protein sequence ID" value="CAE1301527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DK83"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="344"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1301527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="398" mass="43933" checksum="9B6190901F95149A" modified="2021-09-29" version="1">MKVIISAFSDLFQSPLSLSATSLFYITISLSFPNSISFFSPSPILSPSPPSYTALSPLSLSSTSLFYITILSCSPILSVSYSLSFLSPSPILPPFSLPLLSFSTPSFVLCSISSHPILNLSLSTLFLSPATIFSPFFSQSPILFPSPASFSISSLSILHLYPYFSLPTLFSLLSLSFPFSLHPRLRTLLYLLSPYLPLLSSILLLISCHYSLHPLFSILSLFVPSIVPFSLSLSLSLSLSLSLSLSIYLSIYLASLSSMSLLLSLFSFLSFLFPPTLAPLCPLSLSLSLSLSLSTYPGLSPRSLLYHYFFLSSLFSPFSFPSLLKFLSPYIPCSISRLSISIYLSIYLSIYLSIYLSISLYIYTYIYIYILKIRGGSIMSWICFSSLDVGNIEIREDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DRP3</accession>
    <name>A0A812DRP3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_60957</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004269">
        <property type="protein sequence ID" value="CAE1309173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DRP3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032726857" evidence="2">
        <location>
            <begin position="18"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1309173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="235" mass="27041" checksum="484CB0B67ACBB13A" modified="2021-09-29" version="1">MFSFFLCFSLPYPLCLSLPYPLCLSLTYLLCSSFLSFFLSFFLCLPFIFCLSLIKITVFSIRHCKFRFTWGFFQKFFFHQLMKYRFFSFGFFFFSFLFISFIFLISLIFLSSQLLSFLCNLTLTNITNTSHDDDPQLLGSLKQTLKSVSFFSLFTLDLFLIFHSLFLSHVHPLYSTLSLPISPYLSLSFSDSLPIHLVLVSVSVSVTISLNLCLPVSHDLPLLTAGMCSTHPVNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DTG5</accession>
    <name>A0A812DTG5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_61986</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004396">
        <property type="protein sequence ID" value="CAE1310423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DTG5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="350"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1310423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="422" mass="49780" checksum="902EC6B3940E7B84" modified="2021-09-29" version="1">MSIYLSIYIYIHIYLSICLSIYLSIYLYLYLSIYLYIDRFNLNNYIENIALSIYLSIYLSISFCSYLSIYLSIYLYIYLSIYLSIYLSIYLILFISIYLSIYLSIYLILFISIYLSIYLSIYLSIYLSMKWTKMYKYKNVLKLSIYLSIYLSIYLSVFTQIHTTRPHKRSSSLSFFFLINIFPFHSGFSVLFLFLNFSPFNFPFSNTFLRASFFLSFFSLVFLLSFFPSFITFSSFLLSLLFSSLILYSLSFTHLLFTYSYYFASFLLHLLILASTFFIAFFPSLSKHTSFFLVFSFLLLVFPFTFPLSSLFSVSFFSSSPSLLLVFPFPSLFLPCFHFLLLFAFTFDSLFLFVYIFSIAFTCLFACSIYRLSFLFFSLSLSFLLLPLFLQTNYLSLAAVIIIIVIIIIIIIIIIIQNEKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DUL0</accession>
    <name>A0A812DUL0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_62847</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004498">
        <property type="protein sequence ID" value="CAE1311422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DUL0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1311422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="154" mass="17450" checksum="6E6551A26ADD0E14" modified="2021-09-29" version="1">MFVSSLFPPLLFASHSFFPRCFSSLFVAFFFSPHFQTFFHFSLSPRYISAHNTFFDKLFPSFFQLACCMILFFLSLPLDNFEISSSCLRFSLSFNEYAFSSTTSSSLLSPTRPPPATLFSSLSLSLSLSLSLSLSLSLNSFLSVSTRLILYCEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DVP5</accession>
    <name>A0A812DVP5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_59998</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004155">
        <property type="protein sequence ID" value="CAE1308006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DVP5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1308006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="247" mass="28983" checksum="7610F6B2CE20BF5D" modified="2021-09-29" version="1">MAKLFKVTSKQTNIKRKHLSQSDSIYLSIYLSISVSLYVIYLSIPVSSQSFMNLFISIYLSIYLSIYLSIYLSQSVHIYLSIYLSIYLSLRSFHESVHIYLSIYLSIYLSQSDHYLSIYLSIYLSIYLSLFISIYLSIYLSIYLSIYLSLRVLSIHPSLFMNLFISIYLSIYLSIYLSQSSFHESVHIYLSIYLSIYLSIYLSLIIIYLSIYLSIYLSIFHVHLSSKRSCLRFIIFRLIVFTLPASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DX79</accession>
    <name>A0A812DX79_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">FERM, ARHGEF and pleckstrin domain-containing protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">FERM, RhoGEF and pleckstrin domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">SPHA_62174</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Dendrite</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cell projection</location>
            <location evidence="5">Dendritic spine</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Filopodium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Synapse</location>
            <location evidence="15">Synaptosome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004420">
        <property type="protein sequence ID" value="CAE1310631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DX79"/>
    <dbReference type="OrthoDB" id="9990815at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043197">
        <property type="term" value="C:dendritic spine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030175">
        <property type="term" value="C:filopodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008092">
        <property type="term" value="F:cytoskeletal protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13193">
        <property type="entry name" value="FERM_C_FARP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17098">
        <property type="entry name" value="FERM_F1_FARP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01220">
        <property type="entry name" value="PH1_FARP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13235">
        <property type="entry name" value="PH2_FARP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000002">
        <property type="entry name" value="Band 4.1-like protein 5 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000040">
        <property type="entry name" value="FERM, RhoGEF and pleckstrin domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.10:FF:000005">
        <property type="entry name" value="FERM, RhoGEF and pleckstrin domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.900.10:FF:000021">
        <property type="entry name" value="FERM, RhoGEF and pleckstrin domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000046">
        <property type="entry name" value="FERM, RhoGEF and pleckstrin domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000798">
        <property type="entry name" value="Ez/rad/moesin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014847">
        <property type="entry name" value="FA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041788">
        <property type="entry name" value="FARP1/FARP2/FRMD7_FERM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019747">
        <property type="entry name" value="FERM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018979">
        <property type="entry name" value="FERM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018980">
        <property type="entry name" value="FERM_PH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051835">
        <property type="entry name" value="RAC1-GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45858">
        <property type="entry name" value="FERM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45858:SF5">
        <property type="entry name" value="MOESIN_EZRIN_RADIXIN HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08736">
        <property type="entry name" value="FA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09380">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09379">
        <property type="entry name" value="FERM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00935">
        <property type="entry name" value="BAND41"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00661">
        <property type="entry name" value="ERMFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01195">
        <property type="entry name" value="FA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01196">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00660">
        <property type="entry name" value="FERM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="10" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0770">Synapse</keyword>
    <keyword evidence="9" id="KW-0771">Synaptosome</keyword>
    <feature type="domain" description="FERM" evidence="21">
        <location>
            <begin position="12"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="20">
        <location>
            <begin position="619"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="19">
        <location>
            <begin position="838"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="19">
        <location>
            <begin position="1011"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="341"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="397"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="521"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="594"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="947"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="342"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="405"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="452"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="535"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="18">
        <location>
            <begin position="553"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="953"/>
            <end position="967"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00040395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00042170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="CAE1310631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1127" mass="129755" checksum="7F90BB4324E1D145" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DZN5</accession>
    <name>A0A812DZN5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_64536</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004635">
        <property type="protein sequence ID" value="CAE1313367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DZN5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="274"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1313367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="300" mass="34431" checksum="17B3C22A3895DDF5" modified="2021-09-29" version="1">MASSCGSAGDDPLKRKFADSGTSLTTCLNSTSISRLLLRAKHFLLLIDLLFILLPPLSLSLSLSLSLSLFITLSPLITFLPRLLSFWYSFSLLCLGYSSISFCFSHLFYSFSFSLSFSFFLLLSLTHSSTLFLSDSPISLFLSFSYSALYLTSISHYYSFSFYCISVSLLLFSSFFISPPFLIAFSSLSSSSLTLLFFYHFFIFLLFFLFHLFLNIPFHLYSYIKSVYIYLSIYLSVRINLSIYLNLFFIFLSSMPIYLFMFISIYLTGSLLHLSIYLSIYLSIYLSIYLSLFIIYLSID</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E058</accession>
    <name>A0A812E058_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_63432</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004545">
        <property type="protein sequence ID" value="CAE1312179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E058"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1312179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="177" mass="20415" checksum="6806126A1AE24693" modified="2021-09-29" version="1">MYIQKPKYVTFVPSIYLSIYLSIDYSLFLSIYLSIFLSITVCSYLSIYLSIYLSIYYSLFISISLSLYLSIYLSIFLSITVCSYLSIYLLYHISIYLSIYLSIYLSIFLSITVCSYLSIYLSIYLSQSVHIYQSLSLALSLSLSLSLSIYLSIYHSLFISISLSLSIYLSIYQHLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E1Z6</accession>
    <name>A0A812E1Z6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_66405</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004787">
        <property type="protein sequence ID" value="CAE1315486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E1Z6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1315486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="158" mass="17844" checksum="B892EED8D6BE8E20" modified="2021-09-29" version="1">MVSAKEKGSGGSCFSRDTPFFCFLYILSIRYQLYHSLYHDTRLCGAIQERDMILDNLSLSLSLSLSLSFFHSFFRPGALSRVITAHTSHRALRRAKGISDWRKGKRDDETETLSLSLSLSLSLSLSLSISLSFSLILSQWMNACAKQRNFLSSFASFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E2R9</accession>
    <name>A0A812E2R9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_66995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004836">
        <property type="protein sequence ID" value="CAE1316236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E2R9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1316236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="253" mass="30344" checksum="C1FDA1B188109B21" modified="2021-09-29" version="1">MIIKFPYLSIYLSIYLSIYLSIYLSIYLFLFISIYTYSYLSIYLSIYLSIYLSIYLSIYLSLSLSLSLSLYIYIYIYIYIYIFIYMFISVYVSYLSHSAHILAHIYPSIYLLSIIYYLSIYLSIYLCLFILSIYLSHSSIYLSIYLSIYLCLFISIYTCSYLFIYLSIYLSIFYLSIYLVFISVYVSITISFCSYFGHIYLSIYLSIYLSIYLSFPPSFSIILDFLRLFILFFLRIDFPLLQFFLLIFNVIIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E8T9</accession>
    <name>A0A812E8T9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_67781</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004908">
        <property type="protein sequence ID" value="CAE1317172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E8T9"/>
    <dbReference type="OrthoDB" id="8055574at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
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        </location>
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        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="299"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="422"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="494"/>
            <end position="513"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="551"/>
            <end position="576"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="597"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="627"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="776"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="804"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="843"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="873"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="899"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="924"/>
            <end position="943"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1317172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="953" mass="111611" checksum="C6F6A3FFBDACE251" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EB64</accession>
    <name>A0A812EB64_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_71713</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005255">
        <property type="protein sequence ID" value="CAE1321630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EB64"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="348"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1321630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="377" mass="45559" checksum="4F58614BB4E216AB" modified="2021-09-29" version="1">MTEDEISVDIFSLRFILSSASSFFLSFFPSLFLFSFFLSLFFLSFLLSFLLSFLLCFFLSFFLYFFLSFFFSFFFLSFSFFLLSFFFLSFFLSFSFFLSFFYFFLSFFLSFLLCLFFLSFFVSFFPSFFTSFFLSFLPSFFLCFFFLSFFLSFFPSFFPSLFLSFILSFLLSFFPSFFPFFFVSFFPSFFTSFFLSFLPSFFISLFFLSFFLSFLLSFLLSFFPSFFVSFFHSFFTSFFFLSFLLSFLPSFFLYFSFFLSFFLSLFLSSIPSLLLSFFLSFLLSFLPSFSLSFFPSFFLSFLLSFFPFSLSSSIFTPPPSTLFFIFHPQLSFFFLSIHSLTLLPFPRLSIFFFFLFSFFHFFLFRHNHHFLEYANFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EGT0</accession>
    <name>A0A812EGT0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_72025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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            <taxon>Decapodiformes</taxon>
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            <taxon>Sepiidae</taxon>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005290">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EGT0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <location>
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            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1322020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="156" mass="17450" checksum="566B52461BD427D1" modified="2021-09-29" version="1">MPRNVSCKLLRATLSIYLSIYLSIYLSIYLGLSLCLSRSFYLLHFGLSAYLSLFISLSRPFFNLLSVCLSVSVCLSVCLSVSLSLSLYLSIYLGLFIGLCVSRSTFRSICLPQPVYQFVCLGLFIGLSVSACFLSFCLSIYLSIYLSIYLSIYLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EI06</accession>
    <name>A0A812EI06_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_74082</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
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            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
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            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005407">
        <property type="protein sequence ID" value="CAE1324344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EI06"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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            <begin position="6"/>
            <end position="33"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="282"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1324344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="308" mass="36590" checksum="58369785020B3A66" modified="2021-09-29" version="1">MKSQNIPVYLSVCLSVCLSIYLSIYLSIYLNLYIYIAFPFQSFRIYLSIYLSIYLSIYLSLYIYTAFLFQSFRIYLSIYLSIYLSIYLSIYPSLYIYITFPFQSFRIYLSIYLSIYLSIYLSIYSSYVNEFLFSFLLFSSPFSLPPLLLSPSRTTHDMSRFHKETSILRKVTRDNLIRIVMAPSLSVEHLSLSLFLSLSLSLSLGGRFLPSFYFNFPFSLYLDLFVSFLLFPFFLSFFLSFFLSILTSLFFLSILTSFSFFLSFYFNFLFFLSFFLSILTSLFFLSILTSLFFLSFYFNFPFLSFFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EIS2</accession>
    <name>A0A812EIS2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ANO10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_74391</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005429">
        <property type="protein sequence ID" value="CAE1324698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EIS2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="281"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1324698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="329" mass="37009" checksum="56C454C4E6A081B3" modified="2021-09-29" version="1">MSLFLCLCLSFSVYVSLSLFLFLSFSVDVSLSLFMSLFLCLCLSFSVYVSLSLFLFLSFSVDVSLFSVDVSLSLFISVSLSLLMSLFLCLCLSFSVYVSLFPCFSFSLSLLMSLFLCLCLSFSVYASLCPFMSLSLCFCFSLSLLMSLFLFYLSPSLFMSLSFLFLSFSVYVSLFCFYVFSLSPFCLCLSFSVYVSLSLFMPLFLCLCLSLFLFPFLSFSVDVSLSLFMSLFLCLCLSFSVYVSLSLFLFLSFSVDVSLSLFMSLFLCLCFSLSLSPFMPLSLLFLSLFLSSLLISLFLCLSLFISLFCLSLFLRLCLSLFVSVSLFLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EJX8</accession>
    <name>A0A812EJX8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_73862</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005398">
        <property type="protein sequence ID" value="CAE1324074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EJX8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="307"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="385"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="412"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="447"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="480"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="510"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="544"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="584"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1324074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="626" mass="77023" checksum="161A4BAA4E40BB7B" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EKG4</accession>
    <name>A0A812EKG4_ACAPH</name>
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        <submittedName>
            <fullName evidence="7">ALX4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SPHA_74773</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
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        <lineage>
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            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 2 3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005439">
        <property type="protein sequence ID" value="CAE1325104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EKG4"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Paired box 7a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050649">
        <property type="entry name" value="Paired_Homeobox_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329:SF543">
        <property type="entry name" value="FI01017P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329">
        <property type="entry name" value="HOMEOBOX PROTEIN ARISTALESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0238">DNA-binding</keyword>
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            <end position="201"/>
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        </location>
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    <feature type="DNA-binding region" description="Homeobox" evidence="2">
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
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        <source>
            <dbReference type="EMBL" id="CAE1325104.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="487" mass="56347" checksum="60879539F38C7FEC" modified="2021-09-29" version="1">MNVCLPVTYTEISLHSGDYQPSSFQRESRIYFQEKPHPSVINSHLFAAFDLMEDTNSKLKMCKNKDLNLKSENNSNNTSSSNSNILELKPPTLSKVCDVGHSSQVENNDPSVGISGAVDDDLKSEDRNDLKRKKRRNRTTFTSFQLEELERVFQKTHYPDVYAREQLAVHCELTEARVQFQFFLFPIYRFFILSLFNLSLFNSSLFRFLHFPIPPFFNLSLFQFITFPIYSFFNLSLFQFIPLSIYPFFNSSLFQFITLSFPSFSNSFLFQSIPFSIYPFFSLSLFQFIPFSIYPFFNSSHFSLSFCRFLPFSIQSFFTFSIFPFFNISFYHFIISFFFQFLSFSIYPFFNLSIFQSIHFSIHPFVNFSFFNSSLFQSTPFSDPSFYSAFTTLKPKTLLLTSPFHSLSPPSLSPSRPLSLPLATFSPNFSFSISYNAFPHTPLLASFSSIPPPPTSSPRSLVSYGGNAQCRKKHVFLLTLPAPSLIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ELB9</accession>
    <name>A0A812ELB9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_72939</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005352">
        <property type="protein sequence ID" value="CAE1323047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ELB9"/>
    <dbReference type="OrthoDB" id="6173951at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23304:SF189">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23304">
        <property type="entry name" value="SPOT2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="889"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="924"/>
            <end position="946"/>
        </location>
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            <end position="969"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1206"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="322"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="440"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1323047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1234" mass="134760" checksum="60E6A40EAE2B7C67" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ELW1</accession>
    <name>A0A812ELW1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
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        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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            <taxon>Coleoidea</taxon>
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            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="CAE1326837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ELW1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="138"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="179"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="211"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="272"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1326837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="375" mass="44395" checksum="DCF7DF51FF235DEE" modified="2021-09-29" version="1">MRSIYLSIYLSIYLSIYLSISAHLQIDLFIIYWQRFLDRQNTFGCTPPKCIKYVYRDLLLSFSSSYVNSYLSIHSSIYLSIYLSIYLNLFISIYLSIYLSIYYSMFLSIYLSIYLSIYLNLFIHLSIIYIYLSIYLSIYLSSLFISIYLSLFLSIYLSIYLSIYLSIYLSQSVHIYSSIYYSLFLFYLSIYPIYSSISICSYLSIYLSIYLFIYLSFIYLSLFISIYLSLFISIYLSIHLSIYLSQSVHIYLSIYLYLSIHLSIYLSQSRIIVNPFVLISIYLSIYLSIYLSIYLSIIYFSLFISIYLSIYLSIYLSIYLSIYIYIYIYYLRVCSRFLILFSSKSGTPDLTRERQTARYSANPSQGRGNAECHSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EM26</accession>
    <name>A0A812EM26_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_77079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005503">
        <property type="protein sequence ID" value="CAE1327613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EM26"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1327613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="175" mass="19888" checksum="31FCE59459D1242D" modified="2021-09-29" version="1">MIYALITSLASPSSIFFSTVFFLLKPNRNSLLSVLIFFFSFHISGLINLSIIASTPRDALSYFFLSLRSPVPCLLIFFVFIIFPPFFSTLPPLPDILEHLLETNWISLSLRTPIRDRLDSSLTKNTYSTDLIPLSLRTPTRDRLDPSLTKNTFSRLTGSLSYKNTYSRQTGSLSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ENG1</accession>
    <name>A0A812ENG1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_76832</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005498">
        <property type="protein sequence ID" value="CAE1327400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ENG1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1327400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="238" mass="27826" checksum="C70D37FFFA962C68" modified="2021-09-29" version="1">MCACPSFYLSIYKNVYFFIYLSIYLSIYLSIYLSLSLSLFLYLSIYKVCLSVYLSIYKVCLFILICLSIYLSIYLSIYLSISLSLSLFLYLSIYKVCLFILICLSIYLYISIYKVCLFILICLSIYLSIYLSLSLSLFLYLSIYKVCLSVLIYLSIYKVCLFILICLSIYLSIYLSIYLSLFLYLSIYLSISFLSIYLSVYFNLSIYLSICMSVSFNLSLSIYLSIYLSIYLSLSIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ENV3</accession>
    <name>A0A812ENV3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_79215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005562">
        <property type="protein sequence ID" value="CAE1329834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ENV3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1329834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="196" mass="22420" checksum="12874DEB05610A6B" modified="2021-09-29" version="1">MAFLSQVDLRSYRFISLCYSHFETISLLFSSSNLHKSPECIDLPPAKSPPAPLLQQPQPAFIYYQATLTLPPTFTHSLSFSLSLSLFIFFSLAHYPSQSSPLRCQYSTVFEVKRRLRPNWTRSERLCCLAVCLMPGSPWGSRPELLRSPPFSPEGEDTDSQVSTLNSLSLSLSIYLSIYLSIYLYIYIYQYYPVQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EPC5</accession>
    <name>A0A812EPC5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_74890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005442">
        <property type="protein sequence ID" value="CAE1325261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EPC5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1325261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="352" mass="42257" checksum="E9721ADAB1B9AF1E" modified="2021-09-29" version="1">MLPFFHPNFHPSFHSYEFYSSTANLFLSFFLSFFLSFFLFCKSPTCLHISFLLYFFPTFLPHFLLYQYYSYIANRSTFHSFFPSYFLSFFSLNFPFFSLILLLLHSFHPTREFYSYTVCLSFFLSFFLSFFLLFIKSLLPSPFPFLLLPFLLPFFPSFLSYACYSSTDNLSFFLSFFFSFFLSFFLSFFRFFLSLSFFFLFLFHSLNHLFCPRHSFLLYLVPYNLRTLHCQSSSFLSFFFLFSSPFISLVFPISSFVFNINFSCIFPCFLPSIFSFILISFVHRQSFIFSFFLSLKLLFLPRHFFSLGFTPLLSLMSFPFLLLSFQSFLPSYHHRPPPIFLQYLPFFSFIST</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EQP6</accession>
    <name>A0A812EQP6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_80330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005597">
        <property type="protein sequence ID" value="CAE1331046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EQP6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1331046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="233" mass="27265" checksum="229613D6D064CED6" modified="2021-09-29" version="1">MKLNFFLHFLFCLDFFLFLPFFNCLASISFFLSVPFQSPPVFFLFYIFLFLSFFFFLSFFLSFFLKCAIFFSNILSFYPSSTFNFLSFLFFYLESINSSFPFFTLFPVFLRALLFYFVVFFLHSYNLSCPFIFLQYHHLILFLILSLSHTQSFSYLSHSLSHSLSLSLSPFHSLSQCHHNRHHFRPQHLPNPSLPPSRLRSLSTVSAHSSNATTVDATVAEVRTTAVAALQRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EQQ0</accession>
    <name>A0A812EQQ0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_79152</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005559">
        <property type="protein sequence ID" value="CAE1329731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EQQ0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1329731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="168" mass="19892" checksum="56B7A38123317DC7" modified="2021-09-29" version="1">MTMGISSSLSPSLSLSLSLSLPFYFSFRLSLSTFHTAFISLPLTPFLSLSLSLSLSLSLSLSLSVFFFIFISNFVYFSFPSFFLFFYFFYCIFHFFVFKFNFCYRRFFLFFLIFAPTPYRFISFLSFLYFQQFSRYVLSSGSLLLVLFLNTDQYTFYRRTGRLLPNRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EQZ6</accession>
    <name>A0A812EQZ6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">SEC22A_C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SPHA_78446</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Farmed</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Golgi apparatus</location>
            <location evidence="8">cis-Golgi network membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Melanosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the synaptobrevin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005540">
        <property type="protein sequence ID" value="CAE1328852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EQZ6"/>
    <dbReference type="OrthoDB" id="1719357at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044565">
        <property type="entry name" value="Sec22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059071">
        <property type="entry name" value="SEC22a-c_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45837">
        <property type="entry name" value="VESICLE-TRAFFICKING PROTEIN SEC22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25970">
        <property type="entry name" value="SEC22a_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="189"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="260"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Longin" evidence="10">
        <location>
            <begin position="7"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAE1328852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="314" mass="35777" checksum="B0CC0A446CE4FDF4" modified="2021-09-29" version="1">MFIYQTMISRTSDGLPLTASTDSGVAGQNNAKLNLQEGFQQLKLICKKAANFSDRCSYVIGPLAIYFISALNITYSVLCDVSYPSVLAFSFLSDIQKEFLTDYDKSKVDSALRPYSLIAFDTKLQRIKNKYNNPRSLTTKINLSELSQEIKLRPPFQISDFQIQPEKYETIDNGHRSLYYTAASMGGRYIPLGVTGYTALAMSIMCLILHLIHGLNVVSTGHMDIYDEYFTQYAAAFFISFVLTAFQIYLMLFPSKQRKPLATATLISICLCQVYVWEYKSSLIVVSFYIMVAFFTTCIIFSRRLEEKQQHYML</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ERL3</accession>
    <name>A0A812ERL3_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SSD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_79570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005572">
        <property type="protein sequence ID" value="CAE1330255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ERL3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="307"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="368"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="407"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="444"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="476"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="512"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="541"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="567"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="591"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="624"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="664"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="690"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="721"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="2">
        <location>
            <begin position="321"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1330255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="741" mass="90159" checksum="6282AC1272678129" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ES67</accession>
    <name>A0A812ES67_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_79953</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005584">
        <property type="protein sequence ID" value="CAE1330655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ES67"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="237"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="297"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="324"/>
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        <location>
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            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="359"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="389"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="414"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="442"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="469"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="493"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="525"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="559"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="598"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1330655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="633" mass="76799" checksum="5DEEDEAAB14064B6" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ESB2</accession>
    <name>A0A812ESB2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_81452</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005633">
        <property type="protein sequence ID" value="CAE1332426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ESB2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="97"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        <location>
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        </location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1332426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="326" mass="37508" checksum="7B81235A0613D518" modified="2021-09-29" version="1">MQSLFLCTLFLSLIFHSFSLPFFFTLSFFTLSIPLLHSFSLSFFTLSISLLHSFSFSFFTLSIPLLHSFSLSFFTLSIPLLHSFSLSFFTLSISLLHSFSLSFFLSFFILSISLLHSSSLFLSSLFIFLSYISFSLSFFTLSFFTLSIFSSTLFLSLLLNTLFSSAPFLSFLSHFFSLSFFLSFFLPFSSTPLLVLLLHLLPLLLPSFSFFSTLLLSFFLPSFFLPFLLHFLSFLLHSFSLHSCTLFSSSLFLSHCLSFFPSFSSTSLLVFLLHLFSFYFPSFSLYLYTTSLSLFSSFFLSFFFLMHITSATLLIHSIRYTLIYFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EZ86</accession>
    <name>A0A812EZ86_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">INO80B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_81297</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005630">
        <property type="protein sequence ID" value="CAE1332254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EZ86"/>
    <dbReference type="OrthoDB" id="2021186at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23021">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029523">
        <property type="entry name" value="INO80B/Ies2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006880">
        <property type="entry name" value="INO80B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007529">
        <property type="entry name" value="Znf_HIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21561">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21561:SF12">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="INO80 complex subunit B-like conserved region" evidence="2">
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            <end position="305"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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        </location>
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            <end position="272"/>
        </location>
    </feature>
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        </source>
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        <source>
            <dbReference type="SMART" id="SM01406"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAE1332254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="360" mass="40713" checksum="9AEA35501E95C3DC" modified="2021-09-29" version="1">MGKKKDQANEEDTTDSPVSHKKHKKHKKKHKKRKEEEETSPVTHSNLLSDSKPSIKLKIRLGGETLSSKKFVLKDDSNVSVAAFPLTTTSSSVSRTTKPVVSKVATVAKEEHIDVEVDDTQLPDPLASAIHPGFLDPNSIISGILAPSIYPWANQEDAEESLEPEENKEEISNEEQAWLDALEAGELDDFGEIRKPKDPNLLTARQRALLHGKQEQELLELPTGYKTVELTEEQIQRRQQRAKKRRQQAQEKREKDKKQTLERLLKKQETKSKGPKIKSSKRLEIPRYRYVNGVSGIFISMPFGFDFPVSTVPIQEPSKVPMCGVRNCTQPKKYSCSKTGVPLCSLQCYKKNLLIHKLVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AMB6</accession>
    <name>A0A812AMB6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_2057</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000058">
        <property type="protein sequence ID" value="CAE1147201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AMB6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="60"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="563"/>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="678"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="742"/>
            <end position="764"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1147201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="766" mass="92121" checksum="39E076F3D3BC4464" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ANX4</accession>
    <name>A0A812ANX4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_1251</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000034">
        <property type="protein sequence ID" value="CAE1143286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ANX4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1143286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="155" mass="18576" checksum="101BE4F3BF7FBC30" modified="2021-09-29" version="1">MMIEWEKYLDINIFSSYLRGMLFTKIVSLTDYLSIYLSIYLSIYLSIYLHQQENYINLHLSIYLSIYLSIYLSIYLSIVFFSMESNSDFRLTHFAVESCQCKAWFINITWYLTQRKKIKVENKNKNLPHIRLFFLYQLNAFLSHLLIVGAVDSFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AP99</accession>
    <name>A0A812AP99_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_1741</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000049">
        <property type="protein sequence ID" value="CAE1146039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AP99"/>
    <dbReference type="OrthoDB" id="10045817at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1146039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="353" mass="38370" checksum="16AD1A18C78B6A8F" modified="2021-09-29" version="1">MAAVVFTCDPRIEALKFWNLGIYLPLTDKFYTVSSATNSTSVTPPLSPVSVVCSTNSSCSSIDNCSIQSSSTNNIQTNTTTTTTTTTTSTTNVCSHNTGQHNDLSGTAELGLHNAFELLDIDSEHWKNQDEKIVDCLKSPVASRFELRVCGAPPSTPSTSPPLAGVGVADAMVSVSGEEPLTGCITSLQKLKLLCQECRKTDSCKCSKIHLKKKVSSSMLDKFNLARSSSSPRGVIKEARFRPHPSDSTEKSVLRASRLKFLSQLNAAKRAKHMANKSTPIKFDEANIFAISSPSHRTVLGRPINCCSDQEFTTWQILVVPSVHRGEEIEWIPFSARTTGETGHSCNRQGLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812APD3</accession>
    <name>A0A812APD3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_2875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000083">
        <property type="protein sequence ID" value="CAE1150106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812APD3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1150106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="259" mass="30548" checksum="FBBEC2305C5C1E3B" modified="2021-09-29" version="1">MEFANLIFIHFFFFVSLFFFFRIFFCSFSFFFPSLVRFCFSLSSISCNFLSFHTFLHSIFSVTFFLTFFHGLFPLKIFRLPFFLLSLLPPFLPSLLPHIYPSLLLSFLPSFPTSFLLSFLPSFLPFFFLSFLLSFVPFFVPSFQPELIFSLSFFCPSLLSSFYSFSFTLSLPLPFPTFYDLFLSLFPFLFFFLASVLSSFLSFLTFTAPYFVLSFQSFFHCLLTLNLLCPSLLPPFFHSLSFHFAFFIHSFFHSFILSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AQG1</accession>
    <name>A0A812AQG1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_3138</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000091">
        <property type="protein sequence ID" value="CAE1151355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AQG1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1151355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="230" mass="27107" checksum="D17FC5C7997C2475" modified="2021-09-29" version="1">MAFRLNTLKENPNVGYIIELFHLLSTSILFYILISSYLTFILSLFTFQCYSHSVHVFLDLCSYLYHSHSVHLFLDLCSYLYHSHSVHLFLGLCSYLYHSHSVHLFLDLCSYLYHSLCSSLFISFLISVHIYIYHSFTLFISFLDLSCSYLYHSHSVHLFLDLCSYLYPLSVHLFLDLCSYLIILTVHLFLDLCSYLYHSHSVHLFLDLLFIILTCSFFQYLISFFCSSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AS47</accession>
    <name>A0A812AS47_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SPHA_4426</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000140">
        <property type="protein sequence ID" value="CAE1155268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AS47"/>
    <dbReference type="OrthoDB" id="6022771at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="85"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="443"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="110"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="162"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="297"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="479"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="113"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="166"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="180"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="302"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="354"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="378"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAE1155268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="538" mass="61264" checksum="DEEE5C83454E1755" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AU98</accession>
    <name>A0A812AU98_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_5167</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000172">
        <property type="protein sequence ID" value="CAE1157378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AU98"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1157378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="203" mass="22981" checksum="4BD04085BE6061A2" modified="2021-09-29" version="1">MVSLFPSLLHIFSLLRLVSILRLVSLFFSATRLTFLLCNSSLFSLLRIVYILSSATRLSSLFCDSSSLFCDSSLFHFCDTSSFFLLRIVSLLSTATRLSLFFSATRLSFLFYESSLFSLLQFVSLLSSTNRLSFLFYKSSPFFCDSSLFCLIRFAHSYLWTFTQITETSVSENLSKTIESIFCYANSAADFSLTATMCCYHGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AUH6</accession>
    <name>A0A812AUH6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_5730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000188">
        <property type="protein sequence ID" value="CAE1158859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AUH6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1158859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="230" mass="27599" checksum="E90B34AE87406258" modified="2021-09-29" version="1">MIREHGYCHFTDRSFFQRPVFKEVSVFFFFPSFGLSFLFFFPSFFTCCFFLSFFFPFILLFFFLCAFFLSFSLFFLTFAFYLCFFFSFLSRFPFRLFYSLSFPFLFFFLSLTVFYFICFSFFVPFLLFSSFIPFFFFLFSIFLFLSSFLYAFIFSLSSFVYSYYSPSHRFLCFFSFFLPVPQHLCLLPSCCTSICICIYLFISLSFFSLSLSLSLSLSLSVSLSVSHLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AUL7</accession>
    <name>A0A812AUL7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_4916</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000161">
        <property type="protein sequence ID" value="CAE1156752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AUL7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1156752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="169" mass="19671" checksum="388CEA74D1B06787" modified="2021-09-29" version="1">MKGAFYHSSFRKIENLLTDASIKRNVSVLRSLSQVEKFDRVLQVINIHLSIYLSIYLSIYLSIYLTSFSVCLTIYLSIYLSMSIHYLSIYLSIYLSIYLCPFIIYLSIYLSIYLSIYLCPFILYQSTKLSSYTLSLSIFIFFSFINFFTPSKLGIPLVRRVLQRVSAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AV27</accession>
    <name>A0A812AV27_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_5757</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000189">
        <property type="protein sequence ID" value="CAE1158930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AV27"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="290"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="349"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="373"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="397"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="426"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="455"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="481"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="513"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="537"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="568"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="604"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1158930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="632" mass="73280" checksum="AAA6CC6FD44BF099" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AVW8</accession>
    <name>A0A812AVW8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_6772</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000222">
        <property type="protein sequence ID" value="CAE1161289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AVW8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1161289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="243" mass="27933" checksum="019177F0C869322D" modified="2021-09-29" version="1">MDTYIRQSIYLSIYLSIYLSIYFSLSLSLCQIVIRGLNNNSFSTITINHNCTLPFLLLLLLLLVLLLLFFSSSPPLLLIPFFFSSLSSTIFSSFFSLILLLLSSSSFSLLLLLLLFFFFFFFFFFSSSSSSSSSSSSSSFPLLLLFFLSLLLLLFFFFFSSLSSSIFLLLLLFLFFFFSPPLLLVFFFSPPPPPPLLLLLLLLILLLLLCAWSFSGFFLFVLSFLFSFFLSLALSFFLFFFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AYP9</accession>
    <name>A0A812AYP9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_7934</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000257">
        <property type="protein sequence ID" value="CAE1164189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AYP9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="15"/>
            <end position="48"/>
        </location>
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        <location>
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        </location>
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        <location>
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        </location>
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        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        </location>
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        <location>
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            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="280"/>
            <end position="303"/>
        </location>
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        <location>
            <begin position="324"/>
            <end position="349"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="355"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="385"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="443"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="468"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="492"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="537"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="570"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1164189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="627" mass="74713" checksum="6B1C8092A7EAB066" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B561</accession>
    <name>A0A812B561_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_13118</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000436">
        <property type="protein sequence ID" value="CAE1174449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B561"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="19"/>
            <end position="41"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1174449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="265" mass="32252" checksum="E5B5DF8E84346539" modified="2021-09-29" version="1">MCDSLAENKRYSRCLFSSFFLSFLIFLSILLFLSLFLFFLSFCAFTFISYVYIFILFIPSFFSFYIFFLSFVYSFVFFLSYFLSFFLSFLLSFFLSFAYSFVLFLFHFLSFFLFYLFLGFLSFIGFFLSFIPTFFFLFVTSFFLFFSLYCFCLFLHFLSYFSSFVYSFLLFLFHFLSLFLLFRLSVPFNFLPLFLWFILSFFLSFLLSVFLLFVPPFSFPFSFSFFISLFYFFIPFFFLSFFLSFFLSFFLSFLTYTGLNISLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B7U9</accession>
    <name>A0A812B7U9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CUBN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SPHA_10867</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000355">
        <property type="protein sequence ID" value="CAE1169928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B7U9"/>
    <dbReference type="OrthoDB" id="6160518at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="3"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR24251">
        <property type="entry name" value="OVOCHYMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
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        </location>
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    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAE1169928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="644" mass="73771" checksum="1AA10B5AA9635FB8" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BCM2</accession>
    <name>A0A812BCM2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_14340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000490">
        <property type="protein sequence ID" value="CAE1176859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BCM2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
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            <begin position="195"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="291"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="322"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1176859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="357" mass="42842" checksum="225680393DE8E5FB" modified="2021-09-29" version="1">MPSSLLRVSDVIGDHRTLQKLQPISFDFHQPSSRLKIGLSYIYLSIYLSIYLSIYLSIYLFILISIYLSIYLSQFYNFVFINIYSATGSQQYSSLFLIHIICLTSLFLFPFSFFPSFSFFLSFFLLFFVLSFFLFSVYSFDVSLISFSLFLFSFFFSFFFSIFQTISYSLLFFLLPHFCFFSIFLLAFSDIFQTSLFLFLSFLSFYFIIIHPFFFFPLLNFSFIVVFGYYFDFFSSYSFFPLLIFLHISARYISSLTFFFLSLFPSFSLSLFLFLFLSLSLYFFFFLSLSFFFFLSLFLFLFLSLFLSFSLFLCFSFSLSLFFLLSFFFFVFISLFVFHCFSFSLSFFFLKISYYIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BE37</accession>
    <name>A0A812BE37_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_15134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000524">
        <property type="protein sequence ID" value="CAE1178301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BE37"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1178301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="171" mass="20756" checksum="1F58F31FE1E98B7D" modified="2021-09-29" version="1">MLERQNMHDFRRLQMLIEIIYLSIYLSIYLSIYLNSRDEYAIIYLSIYLSIYLSIYLSIYNLIYLSIYLSIYLSIYLSIYLSIYCPMFTFMNNFLIVIFSLAIYLSIYLSIYLSIYIYIYNFLLSTKRLHMSPVSFLSFFLSFFLSFFLSRLFFYSVSSSDLYLQFSFYIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BG67</accession>
    <name>A0A812BG67_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_16190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000566">
        <property type="protein sequence ID" value="CAE1226758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BG67"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="266"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="322"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="377"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="435"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="486"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="550"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="640"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="674"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1226758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="693" mass="80654" checksum="16DD27451B4BDDF7" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BH00</accession>
    <name>A0A812BH00_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_18394</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000665">
        <property type="protein sequence ID" value="CAE1232164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BH00"/>
    <dbReference type="OrthoDB" id="6154438at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000003">
        <property type="entry name" value="Protein CBG25708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000063">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF7">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="251"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1232164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="404" mass="46687" checksum="48F74BE697490A9B" modified="2021-09-29" version="1">MREKIKAELDKMESQGVIRRIEEPTNWVSSLTYVTKRDNTIRVCLDPRALNKALIRPYHQIPTVKELNHRFAGAKFFSKLDAKLTYNKGSDNILADGLSRLPSPGNSDPIELDVRVDTVRFSSDRIEQLRNCTTADPLLNQLRETIITGWPETIKQLPTDIRVFWGLRDQLSIDDGLILKGQQIVIPQTLQDILKQLHTAHLGQEKTKFLAKDTVYWVNINRDIEQFTKSCSICQQHKPSQMQEPLMQHDIPTKPWDIVGTDLFDLHGSQWLIIANYYSKYPVVKHLPAHSPSSVTVNTTRQVFAEFGIPSKVVSDNGPHFSSHLYREFAKEWGFHHETTSPRRPQGNGFRERQIRTVKNILKKKAKKWEQRLKLCCCTGAVLQFQAPYQVLHNYSWVDEFNLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BHB5</accession>
    <name>A0A812BHB5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_16749</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000594">
        <property type="protein sequence ID" value="CAE1228323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BHB5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1228323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="240" mass="28131" checksum="A5EC12ED8E61FB24" modified="2021-09-29" version="1">MFFYSDQVLYSFHLLRAAGYPIFFSHCRHSKPLYVPQEYPSNSGRHVTTVCSSYTNGDKRSLNPYNRIIYEIISKKGFKKEIEEAFSFSLSPSTTVSFFLSFFCARMITGVLFFSFFLSFPFRPLFKGLVTMKLKLLSFSYSFISVWHHSPSRYFFSLFPFSISIPLLRSSLAFFLSFSISCLLSLFHPDVATFRIRRSLFSKIQRFFCVPRACLRSSVRGSMKDFSFYFLHNQRNILRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BHE8</accession>
    <name>A0A812BHE8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_18689</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000674">
        <property type="protein sequence ID" value="CAE1232749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BHE8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1232749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="290" mass="32743" checksum="091B7C3D08BD5A8E" modified="2021-09-29" version="1">MFYQISIYFILTPKTDISEELTNDLNVKQIINVITSFVFPFLLFSYCSPFSSPTLSSSFIFLIFSPLHPPSSFSHLLLFLSSLLILPYLFSSSPPLSLLPSHSSLSLFLIFPSFSPPFSFSFISSSPIFLLPSPPPPSLFCHLLSSHPNPSLFSHLPLFLSSLLIHLHLFFLISPSFSPPFSSSSISFSHLFLLPYLSSTLFLIFPHSLLPSQVFFSSSFSLLPSRFPSFPLFLTPISFFSIDFCIVSIELFSTHFLKYSFSMAFHSFLPLPHFTAFLKPTPFSLHPLYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BHM1</accession>
    <name>A0A812BHM1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_17535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000626">
        <property type="protein sequence ID" value="CAE1229992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BHM1"/>
    <dbReference type="OrthoDB" id="6161790at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1229992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="164" mass="19455" checksum="38C704A539004CF8" modified="2021-09-29" version="1">MNKSVCLYIYLFTYVCLSIYLSIYLSVFTSIDLYLFTSIYLFTYLSIFVHLFIYICTHLSIYLSFFFVYISIYLSIYLSIYLSIYLCLHNNLSIYLSIYRCLHIYLSIYLSIYLSIFLPFPKLNNLPIKFVTVGGPHLSFRSIYLSIYLSIYLSIYLSIYLSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BIH3</accession>
    <name>A0A812BIH3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_16707</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000591">
        <property type="protein sequence ID" value="CAE1228106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BIH3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1228106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="203" mass="24541" checksum="388E1E1EF5FA62B4" modified="2021-09-29" version="1">MIILNNTRRCKQFCNIHANTVYRFNNFFLSFFLSFFLSIFISITTCSTYLSKFMSVCSYTFTYLRILISIYLSIYLSSKPAVYMSGYHHRVFYSLFVPFHSLGIYHFFFFLCKLAFFYYVHLSFIFLLFTPFLFNSLQTSSFSTYKVFSFVPFFSLMLYLFLSFSLLFFFFLRWTHLFISSLSYSFFNVILFINFTLFCFPFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BKK6</accession>
    <name>A0A812BKK6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_17268</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000614">
        <property type="protein sequence ID" value="CAE1229397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BKK6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1229397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="254" mass="29289" checksum="7F6C3F28AA4FFDEF" modified="2021-09-29" version="1">MSIISHNFFLLISIYLSIYLSIYLYIYLYLSIYLSKERVLPASKRNNDLSKLASVAKDNANMVATEIAKPSVVIVTCLSVFVSPYLSLFLSIYLSIYLSIYLFPSIHIYLSMYLSLFISIPVYSYLSISVHSYLCLFISIYLSIYLSIYLSIYLSQSIHIYLSIYLSSKLARYLGISSIHIYLSIYLSIYLSIYLSISVYSHLSQSIHNCACSYLSIYLSIYLSIYLSLFISIVIQSIHIYRCIYLSTPIDKNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BLC3</accession>
    <name>A0A812BLC3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="13">E1.3.3.6</fullName>
            <ecNumber evidence="13">1.3.3.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SPHA_19732</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Farmed</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; peroxisomal fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the acyl-CoA oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.3.6" evidence="13"/>
    <dbReference type="EMBL" id="CAHIKZ030000717">
        <property type="protein sequence ID" value="CAE1235323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BLC3"/>
    <dbReference type="OrthoDB" id="538336at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003997">
        <property type="term" value="F:acyl-CoA oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005504">
        <property type="term" value="F:fatty acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033540">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA oxidase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000005">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000013">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055060">
        <property type="entry name" value="ACOX_C_alpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012258">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002655">
        <property type="entry name" value="Acyl-CoA_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909">
        <property type="entry name" value="ELECTRON TRANSPORT OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909:SF250">
        <property type="entry name" value="PEROXISOMAL ACYL-COENZYME A OXIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01756">
        <property type="entry name" value="ACOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22924">
        <property type="entry name" value="ACOX_C_alpha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA oxidase C-alpha1" evidence="12">
        <location>
            <begin position="86"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase C-terminal" evidence="11">
        <location>
            <begin position="284"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAE1235323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="499" mass="56142" checksum="C4731D873FA35A09" modified="2021-09-29" version="1">MAQLYTQGKCHGIHPFIVQIRSLEDHKPLPGVTLGDIGPKMALNVIDNGFLYVDHVRIPHNHLLMKHCQLQKDGTYIANENNKVFYGSMMYVRAVIILDTYHKLASAVTIAIRYSAVRRQTVLYPNKDEEQILNFQTQQYKLFTVLSKAFAFFFTGSSAIAAYKKVFSDNNEDKEQQFKSLHALLAGLKAISTWNTAEGIKICREACGGHGFSMSSGLPQLESLTCASCTYEGDNTVMLLQTGRYLLKCAQELSNGTKLQGTVAYLEEDFSMGHTQVGGNLHLPALLRLYQHSSQVNLMQVFQQFSKKLASGNSFEEVWNMMSVNIMKSAMAHCLIYTVKTFITGVNDIEQPELKLVLMDLCKLYCVHGIIENLSNFLLPGLLTEIQVSELNDAMFNLLTKIRPNAVTLVDAFAITDRKLNSTLGRYDGQVYSALYDYAMGSPLNKTKVHVSYHRHLQDFLKERQLKANLVSTCTTYSLLLFIRTLFSPTLSHSPVRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BMY2</accession>
    <name>A0A812BMY2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_19648</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000713">
        <property type="protein sequence ID" value="CAE1235137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BMY2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1235137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="186" mass="21271" checksum="EA7380F7DCA8A918" modified="2021-09-29" version="1">MPKEATLSPLSLSLSLTLSLFLFLSLSLSLSLSTLINLSFSPFSPLSPPLSLSLSLSLSLSLSLSLISYISFHVFLTLFNYNFNFSIFFPLSFFLSFFLSFFSFDYLDLFAYSFIYLIYFLFHTHCFLFSSFFLSFFMFSSSTLSSLIGSYNYPPPFLPFIFSFSVPDVFTALLELLDVPQLLRFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BQQ9</accession>
    <name>A0A812BQQ9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_21016</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000774">
        <property type="protein sequence ID" value="CAE1237964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BQQ9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1237964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="176" mass="20611" checksum="F8C36D0FC7225F5E" modified="2021-09-29" version="1">MIKRYIFSLSLSLSLSLLFYLQVSPVTIYLSIYLSIYLSIYLSVMVRFLVPRSHNTIYLSIYLSIYLSIYLSIYLIKFLAIKRPPFFFLVPGYLSFLLCNPKTLLTLFCCLCNSYIRYFLFFSSLSLTRSSHFSSILGKPNLSSLFLFSHDFQYFLLISNISLLSLRTFFLLNIDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BSW1</accession>
    <name>A0A812BSW1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_22326</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000824">
        <property type="protein sequence ID" value="CAE1240444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BSW1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1240444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="232" mass="27515" checksum="93A73437F760287C" modified="2021-09-29" version="1">MICFLSIYNSKSLYCSLIFFAQSLLFYLYSSFNFITYSFFFSYILFVIIYSSFPNSTLVLNQILLHQHLSFYYLFPLCLYPSPPFTIFVIPFFSLVLSVNCLYFFIQSFLSFFFYHYLIRINFTAFFQINPSLSTFLYLLPLLYFPSFSFSYYLFSPPPFLLCLSFSFQLFLFFPLVLLFSLPTKDTSISDLLLSFILTDFISCSSLSTLPIFLIFFLTYYRPVKDDSLFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BVU5</accession>
    <name>A0A812BVU5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_26374</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001007">
        <property type="protein sequence ID" value="CAE1248975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BVU5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1248975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="232" mass="27218" checksum="5D11C7E2A5E55FB8" modified="2021-09-29" version="1">MEKDSFFTVYQPLSVQIYLSIYLSIYLSIYLSIYVFVHIYLSIYLSLFLVYLSSKSVEIYLSIYLSIYLSIFYLSISVHSYMSITAHSLYLSIYLSIYLSIYLFIYLSLSIYLSLFIHICLSLPIHYLSIYLSIYLSIYLSIYHLTVISFNVHNFLFKLNGYGNDCYLSCTLHLSACVLVKSRPPSRSLSSLYTYPCSFFLSRRFYLSRHPSFVPVEPIRVTNSRLFDLPIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BYZ5</accession>
    <name>A0A812BYZ5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_25487</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000966">
        <property type="protein sequence ID" value="CAE1247135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BYZ5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1247135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="176" mass="19804" checksum="A26B6D6675081FDF" modified="2021-09-29" version="1">MNTHQWRKYGNVQAENYVVCSSFGLKYFLFSYQPSHPEPSSSSISITTPFPSICIFLPFLLLLSESLSPPRLFFSSFINSSFFSINLAPFSFLAIYSMSTAILLSFHIELISYLRCHSVVLSTNPSVSSLIALQEWRRLCQSLICNNAVSGIIRMQIGGKGTRMHSMKQASIKKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BZ19</accession>
    <name>A0A812BZ19_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ral GTPase-activating protein subunit alpha-1,Probable Rho GTPase-activating protein CG5521,Ral GTPase-activating protein subunit alpha-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SPHA_24782</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="CAE1245559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="19311at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046859">
        <property type="entry name" value="RGPA/RALGAPB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027107">
        <property type="entry name" value="Tuberin/Ral-act_asu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10063:SF11">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN CG5521-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10063">
        <property type="entry name" value="TUBERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20412">
        <property type="entry name" value="RALGAPB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="569"/>
            <end position="589"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="595"/>
            <end position="618"/>
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    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="630"/>
            <end position="653"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
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            <end position="684"/>
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        <location>
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            <end position="1403"/>
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        <location>
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        <location>
            <begin position="1555"/>
            <end position="1584"/>
        </location>
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        <location>
            <begin position="916"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="433"/>
            <end position="467"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1629"/>
            <end position="1729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1629"/>
            <end position="1652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1713"/>
            <end position="1725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAE1245559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="2203" mass="249696" checksum="90247FAE8EAA57C0" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C1C6</accession>
    <name>A0A812C1C6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CALCRL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_29440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
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            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001171">
        <property type="protein sequence ID" value="CAE1255292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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            <end position="276"/>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
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        <source>
            <dbReference type="EMBL" id="CAE1255292.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="282" mass="31917" checksum="2F73ADD86BA70E2F" modified="2021-09-29" version="1">MAGSPFLIFRDYTIYLSIYLSIYLSIYLSISLYIYIYIQWNLAISTVLSICLSLSLSPSLSPLSPCHFHSFLSISPNNLSLYISTPSLSSHRSPSFLLPQYHTFPLSFPQSFSLRFLSLGIFFTFSLLHCLAISLCLSLYLSHAYYSHLSPIYLCIFHYLRSPLICFSFPNVSLFLSFSLPNLAHIPHPPSLFSLLLTLFLSLSLSPIVLSSLCSSHSISPYYFFLFYSHHSNLPSLPPSSSLHKISLYRSLFPILVILLFPSHFVILSLSLSLSLRLLTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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    <name>A0A812C3T8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">SPHA_30801</name>
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    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
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            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001245">
        <property type="protein sequence ID" value="CAE1257545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
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            <begin position="27"/>
            <end position="52"/>
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    </feature>
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            <end position="86"/>
        </location>
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            <begin position="173"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAE1257545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="240" mass="28186" checksum="5B0D3C29556F17BE" modified="2021-09-29" version="1">MRLRILLYMVSSSTRSTWRLARIRERCLPFTGCTYSLFISQFDHIYLSIYLSSVHIYLSDHVRIYLSIYFSLFISIYLSVHIYLIFCSYLSVWSCSYVSIYFSLFISIYLSIYLSILILRSGWIVGDDKKTKEKQKKTLGSILSIRPTPWRHQWPDQPLFQERSFSLSLSLSLSLSLSLSLMFLQDLSSFIFALCSLDKNPRYLRKKIELRRKKDSSLSLSLSLSLSLSLSLSLRYSFRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C7B4</accession>
    <name>A0A812C7B4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_29678</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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            <taxon>Spiralia</taxon>
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            <taxon>Cephalopoda</taxon>
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            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
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        </lineage>
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            <authorList>
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                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001185">
        <property type="protein sequence ID" value="CAE1255554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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            <end position="20"/>
        </location>
    </feature>
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            <begin position="21"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1255554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="243" mass="27516" checksum="C0B115444AA537CB" modified="2021-09-29" version="1">MYCPLSLSLSLSLSLSLCHSIGVEHSAGDLSRRWKIFWISLNSYRPPQAGQPQASNVSTCYGLPSSLGAWRLETRLADTGSLMEKDYTFFWHRKSSNEPRQRGVGFTVRNSLLNTEEPGRNGSERLLTLRLNTTTSPVTLFGVGKMKDNGQRLLELCTYHNLSTVNSFFRTKPQHKVSWRHLHSKHWYQLDLILVRCTAIKYALPIRSYHGAECDTDHSLVVLQDQAAAQDVPLRQETGESSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CA32</accession>
    <name>A0A812CA32_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_29704</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001188">
        <property type="protein sequence ID" value="CAE1255615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CA32"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="142"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="330"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1255615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="362" mass="42674" checksum="0F82DCC320EA5399" modified="2021-09-29" version="1">MIGQVILTLFQFARQSPVKLSRLSKYFFWDIRSGQHNCSRSERWSCPESDFFFIPSSVPFFLSLVFIFYFLAPFYYLIFFFGEKFPVRRRDVISPLFLLSIRQILSFSFAYLLRFLSCSYHVSLRFFLCNISVSFIHAFPLLPFSRSSFHLSLHFCPILRPFLSFFLSSLLSSFLPLRPVYFISVLQLLLYPIIGLYPLHIIHFILYFPSNLTADIKIIETGIIVGVPAPKDKLADFYGKTKEFLSEYLSIYLSILQSIYVCMYVCMYVSIYLSIPFLTSLFFCLSHFISIYLSIYLSIYLSIYLSILIFLFFTLSVYLSIFLFDCLISIYLSIYLSIYLSIYLSIYRNFNILSESYTCYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CC63</accession>
    <name>A0A812CC63_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_36750</name>
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    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001613">
        <property type="protein sequence ID" value="CAE1269644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CC63"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
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            <begin position="51"/>
            <end position="75"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="145"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1269644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="218" mass="25578" checksum="B55591303804DD44" modified="2021-09-29" version="1">MSGLSFFLSFFLSFFLSLSLFSSLSSRAIFPFLFMCLISTSHSYLSIYLSIYLSIYLVSFIIYLSMYLSAFIHYLSIYLSIYQSIYLLSFIIDLLSFIIYLSCFINYLSIHLSIWFHSLSLYSSIYLVSFIIYLFIYLSCFIYYLSIYLSIYLSIYLSIYLSCFIHLSIYLSIYLSIYLTIFSGSVEDNSSQTKLSIYLSIYLSIYLSIYLSERLPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CDB0</accession>
    <name>A0A812CDB0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_37190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Decapodiformes</taxon>
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            <taxon>Sepiidae</taxon>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="CAE1271322.1"/>
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    </feature>
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        <location>
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        </location>
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        <location>
            <begin position="459"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="485"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="510"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="548"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="577"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1271322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="617" mass="71637" checksum="6B1F68C1BFE6EABF" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CDE9</accession>
    <name>A0A812CDE9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_33189</name>
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    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001389">
        <property type="protein sequence ID" value="CAE1262364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CDE9"/>
    <dbReference type="Proteomes" id="UP000597762">
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    </dbReference>
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        <location>
            <begin position="48"/>
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            <begin position="77"/>
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            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
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        <location>
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            <end position="220"/>
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    </feature>
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        <location>
            <begin position="226"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1262364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="299" mass="35559" checksum="F8D780E04CC3247D" modified="2021-09-29" version="1">MPSRPPISCLSLFIYFLFHSFFLSFFLFFCLSFFSFFSFFLCHCFCHFFFLSPLFLCTLSFFLFFFFFLFFLSLPLFLSLFLSFAFIPLCSFFLSFFLSFFLSLPLFLSLFLISKVFRFHSFYLFLLSFLYHFFIIPLGTPSSRFDYHIDIISPPPQKKMSEIVTPDALIFKLIASIISNEDQRTSRHYFFSFTNYPPPFFLFFLSFHFFPILVGGHFIICPCLFTIYFSLFISIYLSIYLSIYLSHLFIIFSTLSHQARLHFSSSLLDLQHQNGFESSYRVESVFLWGAYLYSNVNSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CED5</accession>
    <name>A0A812CED5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_32662</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
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            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
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            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001363">
        <property type="protein sequence ID" value="CAE1261346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A812CED5"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <location>
            <begin position="31"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="126"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="164"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="198"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="223"/>
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    </feature>
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        <location>
            <begin position="235"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="263"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="337"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="366"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="394"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="424"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="452"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="485"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1261346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="516" mass="61446" checksum="07DDE0119009F1D1" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CFR2</accession>
    <name>A0A812CFR2_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Solute carrier family 25 member 32</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Mitochondrial FAD transporter</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">SPHA_33898</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Farmed</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Facilitates flavin adenine dinucleotide (FAD) translocation across the mitochondrial inner membrane into the mitochondrial matrix where it acts as a redox cofactor to assist flavoenzyme activities in fundamental metabolic processes including fatty acid beta-oxidation, amino acid and choline metabolism as well as mitochondrial electron transportation. In particular, provides FAD to DLD dehydrogenase of the glycine cleavage system, part of mitochondrial one-carbon metabolic pathway involved in neural tube closure in early embryogenesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>FAD(in) = FAD(out)</text>
            <dbReference type="Rhea" id="RHEA:76535"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001428">
        <property type="protein sequence ID" value="CAE1263819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CFR2"/>
    <dbReference type="OrthoDB" id="428293at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015215">
        <property type="term" value="F:nucleotide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015711">
        <property type="term" value="P:organic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000025">
        <property type="entry name" value="mitochondrial folate transporter/carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044712">
        <property type="entry name" value="SLC25A32-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45683">
        <property type="entry name" value="MITOCHONDRIAL NICOTINAMIDE ADENINE DINUCLEOTIDE TRANSPORTER 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 14 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 15" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="67"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="168"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="277"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="28"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00058619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00070508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00079992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAE1263819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="376" mass="41390" checksum="623942DD40ED5F56" modified="2021-09-29" version="1">MSKVANAATAIAVMDASSNVTSKVAGQNSTASNNNSSVNSNNSNSRLFGGLSTSNSKITEAGPLLKWRDMEHLVAGVSGGVLSTLVLHPLDLIKIRFQVNEGTGVTVRPNYTSFLHAIRSIVCSQGFSGLYQGVSANCVGAGMAWGIYFFVYNYVKNHMQAGDQKVKLPPTSHVIAAGQAGVLSLLVVNPVFVAKTRLCLQYEESKDISKDVSKKIKYRGLSDALIKIFQQEGLRGFYKGFVPGVFGVSHGVIQFVTYEEMKSMYNRYNNRPSEQTLKSIEYIAFAAASKMIAASFTYPYQVVRSRLQDQHTSYASCRDVILRIWRYEGLTGFYKGFIPNLLRVTPACCITFLVYETMIAAFERQKMLGTSTELEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CG77</accession>
    <name>A0A812CG77_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_37074</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001641">
        <property type="protein sequence ID" value="CAE1271005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CG77"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1271005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="283" mass="34214" checksum="43F92237B39E6287" modified="2021-09-29" version="1">MFLLSFTVYFFILHFFLSLLSFCLFFSFFFFFVLFLFILISLFLFLLFFVPFCFYFLSLFLVVFSFLFFYIHIFHPSFSFIFLFFFFCSNIFLAFSFCSLLSFNFFSTLIFLFFFFLFHTCFLFVLFLFFHIFFPCLSLFPILLFIPLSFSSSLSFSFSFFYFLFTNPLSSLLFFRLSHFPFLFSFSLSLFVPLPLSLSYFSILFSFSLHSCLLSLFHLAFLTFHFYFLFIIHLSSLLFLAFLTFLFSLFFFPFIALHFLSKHSLFLYLFFLSNFILSFSSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CGH1</accession>
    <name>A0A812CGH1_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SPHA_33721</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001414">
        <property type="protein sequence ID" value="CAE1263475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CGH1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="255"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="291"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="322"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="350"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="67"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAE1263475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="370" mass="43845" checksum="6DA3DC37A24C2514" modified="2021-09-29" version="1">MDNVKSRRRDKIITWRLAYVSIYLFTPVCQSISIYSHMSVISISVNVHLSIYLSIYLSIYLSISVYLHLSIYLSISVYLHLSIYLSSIYLSIYLSISSILIYLSIYLSMSVYSYLCIPVYSYLSIYLSIHLSIYLSIYLSMSIDVYVSISVYSHLSIYLSIYLSIHLSIYLSIYLSIYLIYLSIYLSIYLSLSTSIYLSIYLSIYLSQSIYIYLSIYLKYLRLSIYNSKNFTYICISFSSISFIYHIYIYLSIYLYIYLSIFYLSIYLYVYLSIIYLSIYLSINLSTSKSIYLSLFTFIYLSIYLSIYLSIYLIFILIYLSIYLYLSIYFSIHSFLFIIYLFLSIYHLSIYLCLRPCIYLCLFTSIYLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CI28</accession>
    <name>A0A812CI28_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_35696</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001546">
        <property type="protein sequence ID" value="CAE1267648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CI28"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="342"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="373"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1267648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="426" mass="49795" checksum="8862944D46B183ED" modified="2021-09-29" version="1">MLRFSSSVDANTFFNPTATILYFFDFGIHSYIYLSIYLSIYLSIYLSIYHSPFMVIYLSIYLSIYLSISVCSSLSLYLSIYLSIYLSIYLSIYLSITVHSWLSIYLSIYLSIYLSIYLSQPVCIYLSHSFHFGLFIYMFLTVHSYLSIYLSIYLSIYLSIYFICFYLSIYLSIYLSIYLSIYLISKSSPVAFDPLSTPIPFDPYFSRFHFDPLSSIVPFDTLFSPLPFDPQSSTVLFETLSSTFHFDQLSLPVLFDTLSSPVPFDPLSSSLTFDPLSSPVPFDPFSSRLPRTQFISIYLPTYLPTHLSFFLSFFLSFFLSFFLSIYLSIYASCVTKASYLSIYLSIYLSIYLSIYLISVAIYLSIYLSIYLSIYLSIYSCLEPILLYLSIYLSIYLSIYLSRERERERERERKRERELAYHSTVFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CIS0</accession>
    <name>A0A812CIS0_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein SPEC3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SPHA_36786</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001616">
        <property type="protein sequence ID" value="CAE1269860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CIS0"/>
    <dbReference type="OrthoDB" id="361532at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026673">
        <property type="entry name" value="SPEC3/Stum"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21676">
        <property type="entry name" value="PROTEIN STUM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21676:SF6">
        <property type="entry name" value="PROTEIN STUM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15795">
        <property type="entry name" value="Spec3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAE1269860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="169" mass="19284" checksum="76095E4CAB7C6582" modified="2021-09-29" version="1">MSVASSSFSLDKELAYTKLEEENGYQNLATSESTALFQTCIPYLPVEIAVVCLMFNILIPGFGSILCGIVNFCCGKMQETVKKEDIPMKVFINLLVGFMQLMTVTFLLVGWFWSIAWGIKILLLSIENQKRIKRQKILKEQKQKCKFAFNYAATDDNNDDDEIPPRLKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CKQ5</accession>
    <name>A0A812CKQ5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_38960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001791">
        <property type="protein sequence ID" value="CAE1274573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1432"/>
            <end position="1453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1473"/>
            <end position="1492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1527"/>
            <end position="1550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1575"/>
            <end position="1599"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1648"/>
            <end position="1670"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1682"/>
            <end position="1701"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1707"/>
            <end position="1724"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1736"/>
            <end position="1755"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1761"/>
            <end position="1781"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1788"/>
            <end position="1810"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1816"/>
            <end position="1835"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1871"/>
            <end position="1895"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1907"/>
            <end position="1931"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1937"/>
            <end position="1959"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1966"/>
            <end position="1990"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1274573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="2007" mass="231738" checksum="1929FBE7E11DB6E0" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CNP3</accession>
    <name>A0A812CNP3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_38961</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001791">
        <property type="protein sequence ID" value="CAE1274586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CNP3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1274586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="283" mass="34350" checksum="5D2B5B5F7B2D025D" modified="2021-09-29" version="1">MKIELSGIKNWIEIRDLCHHASFRRVSSSLLQGLLFWSLHNLSIYLSIYLSIYLSIYLSIYFFISILSIYLSIYLSIYLSIYLSISVFSYLSSSIYLSIYLSIYLSIYEQPQKCVLSIFLFIKKHEKLQKYVLSIGIYENPQNLHIIYEKITINTFYLLTSIYEKKNASYLYIYLSMKTAKKRFIYFYLCIYACIYLRKTEKLRFIYWHISLSLSLYIYIYIYIYIYIYEKAQEYVLFIYLSIYEKLQKYVLFIYLSMKNCKNTFYLSIYLSIYLSIYLSIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CQ60</accession>
    <name>A0A812CQ60_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_37934</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001711">
        <property type="protein sequence ID" value="CAE1273059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CQ60"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1273059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="191" mass="23619" checksum="772611E6EFC02B53" modified="2021-09-29" version="1">MLIICYTDNSSYNDVLYFYTQIQDCSLKSLSLKMLNNDSLFVSLKSSFRIYFQFVIYIFLFLFQLFSHFYFQNLLNLSSLPFLPSLFYSFFFEVFLSFIYFHFISSFFFLLTFHSNIFLYFFAYLFLSLKSFFFYFLFIIYILFLVFYLLLFLMLNFSFFLLFSIYYLYFIFSLLFTILTHSYHLFFSIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CRN3</accession>
    <name>A0A812CRN3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_39824</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001868">
        <property type="protein sequence ID" value="CAE1276001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CRN3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1276001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="233" mass="28971" checksum="EC4AE7A9436868FB" modified="2021-09-29" version="1">MQVLPVAITFFLFHFRLLTNRHITRAFFLSSSFFPFLLFSLTFLFLSFPVFHFINDFSLLFFHFLNFFSSQHLFFFCFMPFLLFLIIISSFLVVLSPIFFILFFRSFPLIFFFFFSFFFFPAFLFIFFLFILLFSSSFLYISLFYSLPSILFLFFFYSSSFFFVFTFFFIFYIFSFLFSFFFFDFCNLFLYKFFISLSFFPFFFIIFFFLLFFFFFSLIFHFLSVFFSFPFSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CTI1</accession>
    <name>A0A812CTI1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_40381</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001902">
        <property type="protein sequence ID" value="CAE1276952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CTI1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134:SF22">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134">
        <property type="entry name" value="OS08G0543275 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1276952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="406" mass="48096" checksum="F980ED8D30D4F279" modified="2021-09-29" version="1">MRSIVFFFFKFQVNRHLYVHSRSIYLSIYLSIHLSQFVYISLSISVHIYLNIYLFVYIYLICLYLSIYLSVSRLIIYLSIYLSIYLSISVCLYLSISVHLYVSKYLSQFVCFYLSIYLSIYLSISVHIYLNIYLFVYIYLSISVRSYLSKYRFIYLCLFICISVCSYLSISVCLYLSLFISMFLNIYLSLFVSIYLSIYLSIYLSIYLSLIYLDYIPTDLLPVLSIYLSIYLSIYLSHLFTSIYLSIYLSVCLHILLSAFIYFHLSIYLHILLSIYLSIYLSIYLFLDSDPSFSFLLLLFPSFLPSFLPSFLPFHLSSFLFSSFCLHFTSFSHPIYLSIYLSIYLSIYLNVCSYLSIYLSIYLSIYLSHLHRHNLASSSRHLKGPFCLSTYHRVSFVHPPPRKKKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CX42</accession>
    <name>A0A812CX42_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_43095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002139">
        <property type="protein sequence ID" value="CAE1281853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CX42"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="310"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1281853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="338" mass="41491" checksum="6E887BA85C35BA2D" modified="2021-09-29" version="1">MLLFVFFPSLIFSIFSFTFLTFSFFSFFLFLVSFFYIFSCIPFSFYFFFPYLSITSFFSLFSCLRFFLIFYSLNYSHDYIVLLSPNPFPLPSHHFSFFFFYFFSLYLFLFYLLFTFLFCHSLLLFHPYLLWVFFNPFPPLLQFYLFSFILSATFPSFFLIFFVFLYHFLLRFSLPYLLFTPFSLSSFYSFLLIFFLLLSPYLLFTPFSLSSFFSFLLIFFFLLCFFFTLFFFSIFIFLIFFFSFLFSFSPYLLVFSFFLIFFLSFIFHFFFSPLLSVSSFSSSFFFFFIFLIFFFPFLFFLSFSPSSLSFFVLFSSFILIYFFFILHPYLFLLLPSLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CZC9</accession>
    <name>A0A812CZC9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_42549</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002090">
        <property type="protein sequence ID" value="CAE1280795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CZC9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1280795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="212" mass="24812" checksum="83D5FDD0116999F9" modified="2021-09-29" version="1">MYVYLSVYLSFFLSFCFSFFLSFFLSFFLSFFLSFFLPFQSSPLSLFLSACFCHYLSLSVTLSYFPLFYLLSLSLFFCLLFFYFLSCLFPQHSFTSPPSLSLSSFSLFFLSLLTYRSTSFSPYLSPLSTLSCHFPSFSFYSSHSFTFLYIHTFYFFYFLSYFIPFPSSLLTFPKTFFFSLPTFLSKLSPPPSPPLSLSRSCFTSPSFFLFKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D118</accession>
    <name>A0A812D118_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_45107</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002323">
        <property type="protein sequence ID" value="CAE1285058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D118"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032859034" evidence="2">
        <location>
            <begin position="21"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1285058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="185" mass="21807" checksum="B3F996EED5554B99" modified="2021-09-29" version="1">MILSLSLSFSLSLFLSLSLTATPRLAAYSSPSSSSSSSSSSFSFSFSSSSSSSSSSYYYYYYYYYYYSNETFGFALSFFFSFFHSFFLSFFHSFFLSFFHSFFLSNFLSFFSLHSLICSLYFFMSFFLSFFLSFFLSFFLSVIPVIIFNLIFFPIYARLFLSLFFVSSFRIIVFFLFFFFCQFSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D285</accession>
    <name>A0A812D285_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_46184</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002433">
        <property type="protein sequence ID" value="CAE1286802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D285"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1286802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="223" mass="26819" checksum="187FD311B8A83331" modified="2021-09-29" version="1">MLFLYFFYCFFFRSLFFFFSFFSFFFLVLSSFLSFLFLFLLVSFFHLYTFFLSFFLSIFLSFHAVFLFICFFLSSFIFSFFLSLPLSLPPPLSLLLTVSYLQILFLLPLLIVSYSFYFNFFIVSFTSSSCLHFILAPIKKYSFNFNIYLQIFSDSTLFLNVISFCFLFSISLSSLLPFLVLFISFFLFFFSFSFNSYLFLCFSFFFPLVISFFFFLFYLSSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D4J3</accession>
    <name>A0A812D4J3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_45115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002323">
        <property type="protein sequence ID" value="CAE1285060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D4J3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="279"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="341"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1285060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="402" mass="48011" checksum="9ADD1C5BBE5C577B" modified="2021-09-29" version="1">MENYSQILSNISFYSYLSIYLSIYLCLFMSISVHIYLNLFTSLSLSLSLSLCFSYLSLFISKFIRIYLSIYLSIYLNQSMSIFIIIAKLFLISIYLSIYLSIYLSIYINLFISIYLSIYLSIYLSSVCSYLSIYLSIYLSIYLLCSYLSIYLSIYLSIYVFCNIYLSIYLSIYLSMFLTSIYLSIYLSVCSSIYLSIYLCFFISIYLSIYHLSYLSIYLYIYIYIYIYIYISLFKSIYLCFCNIYQFVHIYLSIYLSIYLSIYLCFLTSYLSIYLSIYLSIYVFLIAIYLSIYLSIYLSIYVFNIYLSIYLSIYLSIYLSIYLSIYLSMFFNIYLSIYLSIYLSIYLYPLTFPLYFPVIYLSIYLYKNICTKNKYVIAILIFKLDVIFSFRSLPKPLEAQFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D4Q7</accession>
    <name>A0A812D4Q7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_46554</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002466">
        <property type="protein sequence ID" value="CAE1287394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D4Q7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1287394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="229" mass="26958" checksum="71A24BAED1441DA9" modified="2021-09-29" version="1">MRDGNVIFRADEKRKKNELSPVTDLHNAYEYCSYNDAIIVSPPRIHCPCALSTYKLNNTSYFTLHIYLSIYLSIYLSIYLSIYLSLAHFNFLSIYLSIYLSIYLSIYLSIYFIIFLAHSFNFLSIYLSIYLSIYLSIYLSIYFCRYLLSIYISCYLYLSIYLLYIFLIYLSIYLSIFLPKSLFSLSIYLSIYLSIYLSIYLSISLFSFLSLSLSMQPLELLSSICISFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D4X0</accession>
    <name>A0A812D4X0_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 5A</fullName>
            <shortName evidence="5">eIF-5A</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SPHA_49985</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Farmed</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts. Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step.</text>
    </comment>
    <comment type="PTM">
        <text evidence="5">eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the eIF-5A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002917">
        <property type="protein sequence ID" value="CAE1293767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D4X0"/>
    <dbReference type="OrthoDB" id="9975114at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <source>
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    <sequence length="172" mass="19525" checksum="5BA3BF6172396EF1" modified="2021-09-29" version="1">MSSFLFSSSAAHTRTQFSRLADVSRLFTKPFVWLKRILKQEMQELLKHSHSNAQACIVEMSTSKTGKHGHAKVHLVGLDLFTGKKYEDICPSTHNMLVPHVKRKDYLLVEIENDGSLSLMEDDGHLKTDLNCPSNELGKEIKERYENGESLTLTVMTAMDEEQVVGYKLDNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D593</accession>
    <name>A0A812D593_ACAPH</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
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            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <end position="27"/>
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        </source>
    </evidence>
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        <source>
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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    <name>A0A812D6M7_ACAPH</name>
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        <submittedName>
            <fullName evidence="2">SERINC2</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">SPHA_48043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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            <taxon>Lophotrochozoa</taxon>
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            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="CAE1290062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D6M7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <begin position="7"/>
            <end position="25"/>
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    </feature>
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        <location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAE1290062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="904" mass="110481" checksum="330E986ADB7FA758" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D9A4</accession>
    <name>A0A812D9A4_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heme-copper oxidase subunit III family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_47559</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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        </lineage>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Cyt_c_oxidase-like_su3"/>
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        <property type="entry name" value="COX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="340"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="Heme-copper oxidase subunit III family profile" evidence="2">
        <location>
            <begin position="111"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1289240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="363" mass="46478" checksum="FD53A629C1856D80" modified="2021-09-29" version="1">MFPYYFILFFLKFAHGLLSFHFLCHLFYFMTVQSFFFFLYSFHIIFPIFFFHYFYFAQFFFFSSSSSNFLSLFCFLKRHITFFSLFFFHSSLNLLLLSCPCNLFLLLFILFSFLFLLIVSSFSSLFISFFHFFFFFSFLFFISSFSFHFFFSFLLFLLFIFFFFSFHLFSSFHLSSFHLFFFFSSLFLLFISFSFHLFFFFSSLLFLLFISSFSSFHLFFFFSSLLFFLVFISFFFHFFFLSFHFFSFFIFFSSFLFFFIFFFFSFLFFFFFHFFFFLVFFFFFHFFFFFFFSFLFFFHFHFFFFFFFLFIFLSFFLFFFFFFFFFFIFLFFFFFHFISFFSILFFFFHFSFFFQIFFLSFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DDE2</accession>
    <name>A0A812DDE2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_50332</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002944">
        <property type="protein sequence ID" value="CAE1294308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DDE2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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            <begin position="21"/>
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            <begin position="296"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1294308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="387" mass="42711" checksum="5D2685F7EEC0D42D" modified="2021-09-29" version="1">MAERPAAILTFGRENKSTLSLSLSPSLSLSLSLSLSLPLIFALELTTHSFYCTLPPSLSLSSSLSPYLSPSLSLSLSLSLFHLSLLLVSLSLSLFHFLFLCLSLFLSPLFLFHFSLILFSMFLFHFLSLSLSLSLSLSLSLSLSVSVLSIYLSLPLSRCLSLYLSLSLSLSIYIYIYIYIYIYIYHFRLHPLSLSPSLSLSLSLCLPHLRMSFICLSCNSLCLSFSLNHSLALCSCLSISLSLSPSLFPFLPLFLSIFHFLLLSLSFSLTLTLFAFNFRFLSLSLIRFLNHRICGIYLSCITHLVSVSFFLFLSLSLSLSPLSLSCSPPSNSLSLLLLDFALPELTGLSALAACGQTHGSCLANRKSPKGLLLNVTERRVSWVGCNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DEG3</accession>
    <name>A0A812DEG3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_52215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003220">
        <property type="protein sequence ID" value="CAE1297753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DEG3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
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            <end position="28"/>
        </location>
    </feature>
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            <begin position="351"/>
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        <source>
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        <source>
            <dbReference type="EMBL" id="CAE1297753.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="373" mass="44505" checksum="31D6CBDA0F5D9ADD" modified="2021-09-29" version="1">MACAGVIAVIISFLSFFLFSFFFLSFFLSFFLSFTYSLFSFFVTVFLLPSFLPSFLPSFLLSLTLFSLSLSQYFFYRITFLPSFLPSFFRLLSFLFLCHSISFAVFPSFLPSFFQHSLFSFFLFFCHLCFIFPSFLSFLLSLTSFFFFVHSFFLSFLPSFLLSFISPFFLPSFFVFSFLPSFLLTFFIFFFCPFVYDCLSFLPFLTFFLNFSFCLTIFIVSFYSILCLSFFLSFFLSFFLSFFLCLPLYLYLSLLFLSIFSFFFLLSIYIYLSIYLCSYLSIESQNIPLSIYLLFIYLWFFLFSVFHIYLFYLFYLSIFYLSSFHIYLSVYLSMNLSHLSKGLSQLFKHSLFSNFPPLLILSVFPSIYYPFIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DI75</accession>
    <name>A0A812DI75_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_54652</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003569">
        <property type="protein sequence ID" value="CAE1301831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DI75"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <begin position="6"/>
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        <location>
            <begin position="675"/>
            <end position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1301831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="695" mass="84225" checksum="00775052B70F0A33" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DIG5</accession>
    <name>A0A812DIG5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_56981</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003813">
        <property type="protein sequence ID" value="CAE1304404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DIG5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1304404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="153" mass="18512" checksum="F4FBE76075E0B032" modified="2021-09-29" version="1">MFTFLYISISISIYLSIYLSIYLSIYLSIYIYIYIYIYIYAKAKHEYRHPIYLSIYLSIYLSIFPFSHLMGGIYLSIYLSYLSIYLFLYLFLSLSQTLIHMRTEHQLISPFLFLSIYTYLYLFLPFSQYLYLSFYLPPLSIFVFMNSFRPATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DIQ2</accession>
    <name>A0A812DIQ2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_52498</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003271">
        <property type="protein sequence ID" value="CAE1298261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DIQ2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1298261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="176" mass="20497" checksum="54A9D76998D8BE4B" modified="2021-09-29" version="1">MLIIYIDFISRNNKNIPSFLSIYLSIYLSIYSPVLSIYLSIYLSIYLSIYLSKPVHIYQSIFSYSDNIQERDSIFNVPIYLSIYLSIYLSIYLFLSISIYLSIYLSIYLSIYLSIYLSGFSYLSIYLSIYLSIYLSIYNIDVFHDACSQPTSSVGLRKNVVSIGNFCAKVDKRRDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DJZ1</accession>
    <name>A0A812DJZ1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_54488</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003537">
        <property type="protein sequence ID" value="CAE1301518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DJZ1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1301518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="329" mass="40715" checksum="7B5FCA9875ADB20A" modified="2021-09-29" version="1">MFPYSFFHFHLFLLFPYSFFLSFFIFLNSFFLNFFFFLDLKSSFFPSFFPFLFSFLSFPFLFLSFLYFSCFLFSFCFLFYPFFLFPTLFFLSFLSFSLLFQQPFLFFSCLFPYSFFLFFLSFCLLFLSFCFLFSFLSFFLFPSFFSFFLSVSLLFLSFFLFPYSFFLSFFLSVYFYFFLFFLLSFLSFCFPTLSFFLSFFLFLSFFLFLSLSFFLSFSVSLFLSFLSFCFLSFFLFLSFFLSFFLSFFLSVFFLSFFLSFFLCFPFFSFLFLFLSFFLFFLFPYSFLSFFLFLSFFSFFLFSFFLSLFLFFVSFFFLFPYSFFLTQLIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DK55</accession>
    <name>A0A812DK55_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_57547</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003885">
        <property type="protein sequence ID" value="CAE1305014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DK55"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1305014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="203" mass="24161" checksum="1495BAD065549C69" modified="2021-09-29" version="1">MSFCCVPVNPQTYGHALPLSAFSTRNNIPKNGQRADLPEPSLRARHNDCQCACSLFLHSFQTVLQFRPLFPTLPPFSYFSSFSFTFRPPLFVRFHFFFFIYICFLHSPSLTSASLLLLSFPILFFVLLDYHYHHYDFLLLLLLLLFLLLLLIFLILTQHLSYFFLYFFFTFFILFFFLLLLLLIVLKLLFLFLHISHTYRFIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DKI4</accession>
    <name>A0A812DKI4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_54821</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003604">
        <property type="protein sequence ID" value="CAE1302123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DKI4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1302123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="206" mass="24720" checksum="8699AFF4D9040746" modified="2021-09-29" version="1">MFSLLPFFFIFFISLSFFLSCFLFVNEFCNTHSIRTLFVASCFLTSGFFFLRFSLHMFFFFLSGDFLFLFFFLSFFLSFFLSFFLYLFPVISLFLYLFILFRCFLSFFLSFFLSFFLSLNAFSSTYRHRSSSSSSSSSSSYLSNYLSFFISIYPQFLSLFLLFFSSFSFFLSFFLSFFLSFFLSFLFPPCYFSIYGVFLLYNIPVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DKL5</accession>
    <name>A0A812DKL5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_53487</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003408">
        <property type="protein sequence ID" value="CAE1299891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DKL5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1299891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="249" mass="29607" checksum="AF47C9F71347E020" modified="2021-09-29" version="1">MHSIYPSIYLLSIPFLSLFPIYLSIYLSIYLSIYLTLHCLSHTHTLTFSLSFPLYLSIYLSIYLFIYLSKIFIFSFFLSFTFSLSLSLYLYIIYLYIYLYFFLSLSLTHSFSFSHAHIDLRFFSLSLSLSLSYTPSLSFTHTHFICIYLFLTHTYSDSLLFSLLRTHTLTFFLPPSLSLYIYITYSLSHMNTLTLFLSYSLSFFFPLLHTSNFSNNLFIFSYTLNFLIASFLFFSFLQFYLIHISFFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DM25</accession>
    <name>A0A812DM25_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CNTROB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SPHA_58535</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004007">
        <property type="protein sequence ID" value="CAE1306243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8190486at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007099">
        <property type="term" value="P:centriole replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051299">
        <property type="term" value="P:centrosome separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902410">
        <property type="term" value="P:mitotic cytokinetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902017">
        <property type="term" value="P:regulation of cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038923">
        <property type="entry name" value="Centrobin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34439">
        <property type="entry name" value="CENTROBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34439:SF1">
        <property type="entry name" value="CENTROBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="434"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="461"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="490"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="537"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="565"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="591"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="631"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="670"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1955"/>
            <end position="1977"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1989"/>
            <end position="2010"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="57"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="151"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="255"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1134"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1337"/>
            <end position="1359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2148"/>
            <end position="2174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2195"/>
            <end position="2286"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="839"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1068"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="61"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="268"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="290"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1340"/>
            <end position="1352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2162"/>
            <end position="2174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2205"/>
            <end position="2219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2220"/>
            <end position="2231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2239"/>
            <end position="2259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2268"/>
            <end position="2286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAE1306243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="2286" mass="252935" checksum="684A0390FABF9948" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DM51</accession>
    <name>A0A812DM51_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_58881</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004056">
        <property type="protein sequence ID" value="CAE1306694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DM51"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1306694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="228" mass="26249" checksum="D83FCAECC8DA62D4" modified="2021-09-29" version="1">MMKKTTRVKPPGLRYELKFLSGKFENHQFRPVTESSTSLRLVYVVGSWSGEDVRRTKKFTTVFPSSLTSFVAVPLSFPVRFLAFFFLFSYSIIPVFSPLSLLHLIYHLLSLFIILSLYNSLSLMSSCSLFLNLIFPLLSILLFHSLYLNLASLSFIHSFICCFLFSLSLSLSLSLSTHPLIIFALFNIRCFSSVLYFLNSNLLFFAVCYFLSLFLFYSRRLILVFSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DMI7</accession>
    <name>A0A812DMI7_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SPHA_54461</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003537">
        <property type="protein sequence ID" value="CAE1301558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DMI7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003915">
        <property type="entry name" value="PKD_2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01433">
        <property type="entry name" value="POLYCYSTIN2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="314"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="348"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="376"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="107"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAE1301558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="410" mass="50004" checksum="D7B3DE51C2E12ED7" modified="2021-09-29" version="1">MHISIYLSIYLSIYLSIYLSILLQTLRAFAVRLRFLFFFYLIIWLFSILSFFTFSFSFSLSFATPPFLLHSAIRHFLLSFINSLLPFCLSHYIYFLVCFYFHLIFSLSLSFTFLIFFSFFVSVLFISFFFLFSFLDLLLSSFFLFFCCCIAFFLCRVTFTVFLSFFVLYFFFLCYFIFSFLFFLSFFLSFFLCYITFSFFLSFFLCYITFSFFLSFFATLLFLYFFATLLFFLSFFLSFFLSLLLYFFFLFSILATFSFFLCYFTFSFFATLVFFFLSFFATLLFLSSFLSFFATLTFLSFFLCYFTFSFFATLVFFFLSFFTTLLFLSFFFSFFLCYFDFSFFLPLLLYFFFLCYFSFFFLSFFLSFFLSLLLYFFFLSFFFLSFFFFSFFATLTFFLSSFATFSFFAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DN93</accession>
    <name>A0A812DN93_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_59135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004098">
        <property type="protein sequence ID" value="CAE1307047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DN93"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1307047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="181" mass="20989" checksum="3CBDF21E5A1614CA" modified="2021-09-29" version="1">MPFVCVAQAKFYLSIYLSIYLSIYLSLFISIYLSQSVHIYLSIYLSIYLSIYLCSYLSIYLSIYISIYLSQLISIYLSISVCSYLFIYLSLFISIYLHLSIYLSIYLSISVHIYLSIYLSPSVHIYLSISLASYLCSYLSIYLSQSVHIYLSISVCSYLSIYLSIYLSIYLSILSCSFIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DPC8</accession>
    <name>A0A812DPC8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_58201</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003966">
        <property type="protein sequence ID" value="CAE1305853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DPC8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="303"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="370"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="458"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="499"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="538"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="563"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="605"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="636"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="680"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="714"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="746"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="788"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="813"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="841"/>
            <end position="863"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1305853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="960" mass="112863" checksum="E420228FF2D484B2" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DQ88</accession>
    <name>A0A812DQ88_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_60142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004163">
        <property type="protein sequence ID" value="CAE1308238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DQ88"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1308238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="249" mass="29997" checksum="3401D224CF6A0F85" modified="2021-09-29" version="1">MFCSYVDHSLPPHFFLSYSVALLFIYLASSFFSFFLSPSHFFFFFLSYSVALLFIYILLLFFFFFLSYSVALLFIYLAFSFFFSFFLFCGSINCIYSLLIFFLSFFLSYSVVLLFIYLAFSFFSFFLSYSLALLFIYLAFSFLSFLFCGSIICRTLFLFLDLLFFLFFFLCIYYVSYLFLFTTLLFFLSFFLIRWVYYLSYSHSLSCPLIFSFFLSYLFFGFITNLNHFLIIAFLFFLILCLLFILLFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DTR1</accession>
    <name>A0A812DTR1_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Probable D-lactate dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="10">1.1.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">SPHA_59042</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Farmed</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Involved in D-lactate, but not L-lactate catabolic process.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(R)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13521"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13522"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="13">Interacts with CSRP3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FAD-binding oxidoreductase/transferase type 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.4" evidence="10"/>
    <dbReference type="EMBL" id="CAHIKZ030004081">
        <property type="protein sequence ID" value="CAE1306809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DTR1"/>
    <dbReference type="OrthoDB" id="5332616at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004458">
        <property type="term" value="F:D-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008720">
        <property type="term" value="F:D-lactate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903457">
        <property type="term" value="P:lactate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.45.10:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2740:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.43.10:FF:000010">
        <property type="entry name" value="probable D-lactate dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000030">
        <property type="entry name" value="probable D-lactate dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-bd_oxidored_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748:SF111">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
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    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="381"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="418"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="445"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="470"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="499"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="527"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="553"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="16">
        <location>
            <begin position="69"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00053432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00063083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00072812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAE1306809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="706" mass="79069" checksum="2B98DF0C32B27931" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DUZ3</accession>
    <name>A0A812DUZ3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_59006</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004081">
        <property type="protein sequence ID" value="CAE1306933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DUZ3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1306933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="259" mass="29013" checksum="46082CB0929D9A2A" modified="2021-09-29" version="1">MNPYKTPFSLSLFRSLSLFLSFYFSLCFCLSLSVSICFFLSFSFFSFSVFLSASLSLSLSLSITSLYFSRFPSVSVSLFVSCSLFLSLSSLSPSFSLLLSLSLYYCFPLSLSMFLALSLFLSFVLSFFLSFLSLFSFSVFLTVSLCLLLFFFWPLCLYLSLFLSVSFSLSVSCSFSLSLSLSVCFSNSSPLFVAASFSRTHSILLSFFISLFLRFSLSLLFSLSFCFSLSFCSSLSQFLSLPLPFLSSLSLFLSYTHTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DVJ7</accession>
    <name>A0A812DVJ7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_60606</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004221">
        <property type="protein sequence ID" value="CAE1308784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DVJ7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
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            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="55"/>
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        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1308784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="240" mass="28572" checksum="80B4496FC371DD89" modified="2021-09-29" version="1">MYLSIYLSIYLSIYLSIYSFQFITTYLSLSLSIYFNSYLSIYLSIYLSIYLSIYLSMQCISIYSFQFIIYLSIYLSIYLSIYSFQFITAYLSLSLSIYSFQFISIYLSIYLFISIHNYLSLSLSIHFNSYLSIYLSIYLSIYLSIYLSSSSLSIYSFQFISIYLSIYLSIYLSIYLSIYFISLSLAFSLYSFKSLFLYFISTPPVFSFQFISLYLLHCLLYLRRNQFKFFPVIFFSLDIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E1N6</accession>
    <name>A0A812E1N6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_65532</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004724">
        <property type="protein sequence ID" value="CAE1314557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E1N6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="410"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="436"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="473"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="524"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="557"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="584"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="611"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="637"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1314557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="674" mass="80947" checksum="2B595F352670B199" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E2P0</accession>
    <name>A0A812E2P0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_66971</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004834">
        <property type="protein sequence ID" value="CAE1316189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E2P0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="301"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="330"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1316189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="353" mass="41158" checksum="CCD1257D1DC6E10F" modified="2021-09-29" version="1">MKHVSICRSGWLVIYLSIYLSIYLSIYLSQSVLIYLSIYLSIYLSIYPILIISIYLSIYLSIYLSIYLSISVCSYLSIYLSIYLSIYLNLFISIYLSIYLPHSDHIYLSIYLSIYLSIYLSQSVHIYLSIYLSIYLSIYLNLFISICSIYLSIYLSISLFISIYLSIYLSIYLSISICSYLSIHLSIYLNLFISIYLSIYLSIYLSLFIYLSTIYLSIYLSVCLSVYLSIRILCLFLIYLFIYLCSYIYLLLIYVFNLSVLILCLFLIYLSLFIYLSTFIYLPICLSISVFSYLSISTFSYLCLFLIYLCSSIYVSISSVPIYLSIYLSIYLNLSISIYLSVYSTGIGLTFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E3N7</accession>
    <name>A0A812E3N7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PGRP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SPHA_66607</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Farmed</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004810">
        <property type="protein sequence ID" value="CAE1315745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E3N7"/>
    <dbReference type="OrthoDB" id="10001926at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06583">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.80.10">
        <property type="entry name" value="Peptidoglycan recognition protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036505">
        <property type="entry name" value="Amidase/PGRP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002502">
        <property type="entry name" value="Amidase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015510">
        <property type="entry name" value="PGRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006619">
        <property type="entry name" value="PGRP_domain_met/bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11022">
        <property type="entry name" value="PEPTIDOGLYCAN RECOGNITION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11022:SF41">
        <property type="entry name" value="PEPTIDOGLYCAN-RECOGNITION PROTEIN LC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01510">
        <property type="entry name" value="Amidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00644">
        <property type="entry name" value="Ami_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00701">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55846">
        <property type="entry name" value="N-acetylmuramoyl-L-alanine amidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032531666" evidence="2">
        <location>
            <begin position="26"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidoglycan recognition protein family" evidence="4">
        <location>
            <begin position="30"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetylmuramoyl-L-alanine amidase" evidence="3">
        <location>
            <begin position="40"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAE1315745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="173" mass="19869" checksum="1A2D1AC4E7F4DA77" modified="2021-09-29" version="1">MYSMSNAFNCFVCFMAIAVATKTESTCSQIKLIGREQWGAKLPKDVVSMKTPVRYVFIHHTAMGECFNLTTCIEQVKEVQDLHMISRKWSDIGYNFLVGEDGRVYEARGWNRTGAHTKYYNQVAVAVSVMGNFMKRIPNQIALDATSIRSEHFYHTLKKIKQIKFVINKPLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E5Q9</accession>
    <name>A0A812E5Q9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_67107</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004854">
        <property type="protein sequence ID" value="CAE1316366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E5Q9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1316366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="199" mass="23217" checksum="46E768EFD2BA607F" modified="2021-09-29" version="1">MLNLHYPSIYLSISSHIYLFSSLFMYLDLSISVHIYLCLFISIYLSIYLSSSTDRLFLCHLSIYLSIYLSIYLSIYLSIYFVSRSLARFALSLYKLLLIKTQVEIIFCRVLSLSLSLSLSLSPYICLPFISVSVCSYLSIYLCSYMTVFFLSISVHISLFSYLSIYLSIYLSIYLSIYLSIIRTFTDMETPPFFFFYAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E5U6</accession>
    <name>A0A812E5U6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_67152</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004860">
        <property type="protein sequence ID" value="CAE1316437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E5U6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1316437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="205" mass="23718" checksum="3F52C5651EEAE0E4" modified="2021-09-29" version="1">MQTRILMFHVPACPNSGDESVALFHCSYLIFLLLVALSVEQPNLSACLSVCLSIHLSISFCSYLSQSVHIYLSIYLSIYLSIYLSLSIYIYIYIYFRLFISIYLSIYLSIYLSISVCSYLSIYLSIYLSIYRHGFFISIYLSIYLSIYLSISVCSYLSHSVHIYLSIYLSIYLHGSVHYLSIYLSIYLSIYLSNKYNTPFCHPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E6J1</accession>
    <name>A0A812E6J1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_68002</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004932">
        <property type="protein sequence ID" value="CAE1317458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E6J1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1317458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="178" mass="21301" checksum="76063D636D8DC2B6" modified="2021-09-29" version="1">MLFLVYLSFHSFLFSFFFFFFLSFFSSFCFAFSLSFLFFFLSFLHSALPFLFPFSVFLLNVILYLSFIPLSFLSFFSSFCFAFFHSLSFLFLFLYSIECYSLPYFIPLSFLSFLFFILLCLFFPSLYSIECLVSFLSFFSFFLFFILLCLFFLSFFSSFCFAFSLSFLCIPIECYSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E9P9</accession>
    <name>A0A812E9P9_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SPHA_66966</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004834">
        <property type="protein sequence ID" value="CAE1316182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E9P9"/>
    <dbReference type="OrthoDB" id="5987936at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24235:SF29">
        <property type="entry name" value="GH23382P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24235">
        <property type="entry name" value="NEUROPEPTIDE Y RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032438408" description="G-protein coupled receptors family 1 profile domain-containing protein" evidence="9">
        <location>
            <begin position="20"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="105"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAE1316182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="456" mass="51098" checksum="9A1DF104C7006C5F" modified="2021-09-29" version="1">MAALASAVTLHSLLPALNTTLYNISITGANQLGSNVTNIGRSTEVASIHYSMAVTITEAFNGSIDYDEYYLERIPYPRKLKQYPVWEILLKIFIYVLVIVMATTGNCLVITVVFTNSRMRTTTNYYIVNLAASDLLVTLSCSWVHLVSSLNEDWVLGAFFCKFNSFAQGKGFPFLMFSLLLSLSLSLFLSLSLSLSRSNISNSFFLHFFLTFPSILSIYLSIPFCFYLSIPSIYLSIYLSIYLSIYLSIYSYLYIYIYIYIYIYIYIYIYIHTSQSVHIYHFISNSFLCLSYSFFLNNFSSFFSLPQQLSLSLSLSLSLSLSLSLDIGIVRVPVNGVPSSNSTESGRVRFLSGIVRVPANGVPSSNSTESYRVPFLSGIVRVPANGVPSSNSTESGRVHFLSGIVRVPANGVQSSNSTESDIFIITGDIYIQLYIFIITDDIYIITHHIFIITPDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E9U5</accession>
    <name>A0A812E9U5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_68750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005016">
        <property type="protein sequence ID" value="CAE1318249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E9U5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1318249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="374" mass="43070" checksum="85ACD6E1B5E51295" modified="2021-09-29" version="1">MSFFLPFIPPPLSHFPPLFFFFIISHYFLLDHSLCPLSVCLSVCLSVSLSLSLSYPCLSPISFSLFYFLSSHSLVIFSSLSLFVSFFHSLYSLSIRPSFLLTFISPSFSKTVSHSFFSFSFSLFFVFPPPLSFSSSLAIFFLSLSLDLLFFLLFTLSIFLIFSSTSFSFYALSFFTSTSFFSFFLSLPLCHFFPSSHSFFSRYFTPSFPFLSQSFFLFLPFSHFSFGLIQCLPLSISFLCLLFNSSHLYFTLCPSLVPFKPLSLCLILFAAVSLPFSFSRFPIHRCFNLLYNQLSSIVSLSIPMFINSFLSPFFFLSFFFLSFFLSFFLSFFPLFHRFPSPHPSIPHFLYLPPLFYSFIPFSNFFSLSLSLSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EC65</accession>
    <name>A0A812EC65_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">TGF-beta family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SPHA_72395</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TGF-beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005316">
        <property type="protein sequence ID" value="CAE1322390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EC65"/>
    <dbReference type="OrthoDB" id="5987191at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.90.10:FF:000001">
        <property type="entry name" value="Bone morphogenetic protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001839">
        <property type="entry name" value="TGF-b_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001111">
        <property type="entry name" value="TGF-b_propeptide"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015615">
        <property type="entry name" value="TGF-beta-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017948">
        <property type="entry name" value="TGFb_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11848:SF263">
        <property type="entry name" value="PROTEIN DECAPENTAPLEGIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11848">
        <property type="entry name" value="TGF-BETA FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00019">
        <property type="entry name" value="TGF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00688">
        <property type="entry name" value="TGFb_propeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00204">
        <property type="entry name" value="TGFB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00250">
        <property type="entry name" value="TGF_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51362">
        <property type="entry name" value="TGF_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0339">Growth factor</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032683955" description="TGF-beta family profile domain-containing protein" evidence="11">
        <location>
            <begin position="24"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="491"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="TGF-beta family profile" evidence="12">
        <location>
            <begin position="339"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="311"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="323"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAE1322390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="514" mass="58748" checksum="1AD63CA4932D8719" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ECT4</accession>
    <name>A0A812ECT4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_69950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005110">
        <property type="protein sequence ID" value="CAE1319537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ECT4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1319537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="250" mass="28958" checksum="B5C11DA961FBD6DA" modified="2021-09-29" version="1">MCVKTSAPLHANLFIGLFVSLSSFSFFPSAIYLCHSVHIYLSIYLSIYLLQSFNVYLSIYLSIYLSIYLSMSFCLYLSIYLSIYVILSVSICLSIYLSIYCSLLTSVCMFIYLSIYLSISTCLNFSISLSSSLYIYLFIYIYLSIYLSIYLSISIFPWSYQSVSIFYLTRPFNIRLYFSCPIHIYRSVPTQPLLFPDLALKHRIPIIFPNRPMHPTFFSTLFSTLSAPRLPTFCPLNQLPFIMISSNIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EGM0</accession>
    <name>A0A812EGM0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_72716</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005341">
        <property type="protein sequence ID" value="CAE1322812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EGM0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1322812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="154" mass="17363" checksum="E63108B64998273B" modified="2021-09-29" version="1">MNRVHLVTIYTHPPLLPFGWFFGPHPPTLSISAAVPPHPIPPPRRTNISVCLFNPLFSRLLSFPFFILQTETCCHLLLLHFSLCFHTRLPHPPSPPTFCQTTSFFCLATTQGFKGSHQDAGRQISIDTYVLWALKLCLLSMCVYTPTKGDNCLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EHF2</accession>
    <name>A0A812EHF2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_72605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005335">
        <property type="protein sequence ID" value="CAE1322687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EHF2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1322687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="168" mass="20238" checksum="397F5153DC66CFCB" modified="2021-09-29" version="1">MCGFKFRRCPSFYVKCWVGRLQFFFLSFFLSFFLSFFLSFFLFHSFFISLVFFFFIFLLRSRIPSHEIFLFFSFFLEHTYLLSCFLFCFFHTQLLISQNISFSFSSFFLSFFLSFLLACLIYWFSSFSISLFSLINIFLSLSLSLCILCHSFVPVPVIHSLFLHCVFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EHV1</accession>
    <name>A0A812EHV1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_75723</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005470">
        <property type="protein sequence ID" value="CAE1326132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EHV1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1326132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="306" mass="35996" checksum="C42B3E38B70D92BE" modified="2021-09-29" version="1">MEYCIYFFLILLPFLAVFSFFLPDAAVVKEHDFVFFLLLTRNKPANRASERLTKRHLKRRLSLSNSFVPFSLSLYLPCFHFFLSHSVHIYLSIYLSIYLSIYLYPSLLVSVYLNPSNIYLSIYLSIYLSIYLSIKLLDFDRQKGISYTLTTSCLPSFLSSFLLSIYLSIYLSIYLSIYLMDYNIYLSIYLSIYLSIYHLYSYLSIYLSIYLSIYLSKPVHYLSIYLSIYLSIYLSIYLSIQATSYLTLFISIYLSIYLILSLSISIYLSIYLSIYLSNSNYLTLFISIYLSIYLSIYLSIYLSNCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EIV9</accession>
    <name>A0A812EIV9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_71711</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005255">
        <property type="protein sequence ID" value="CAE1321622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EIV9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1321622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="231" mass="26095" checksum="E5DFC6011C531156" modified="2021-09-29" version="1">MSDDLTLKQLYTADIPDAIKQLGMNYENLKQVADYCETNYNEVRKALILFFFLSISLSLSLSLLFFSFPSLSLSFSFSFPLSLSLSFSFPFPSLSLSLSPFLFLSLSLSLSLLFFSFPLSLSLSLSFSFPFPSLYSLPLYIYIPSLSLPSPSYSLSFPPLFSSLVLSFYLSFSLSLSFSLSLSLTLTHNFSYLQKVFAIVLRQLLVSFFTLLDSVIYASHSPYFEKSFTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ELP6</accession>
    <name>A0A812ELP6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_74786</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005439">
        <property type="protein sequence ID" value="CAE1325117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ELP6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="303"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1325117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="383" mass="43823" checksum="27ADA451A23815F7" modified="2021-09-29" version="1">MFVWVDKGVTTIQIFKNKNQSKTYFAKITFISRLCFLRLIICFDFRSIYLSIYLSIYLSIYLSDLSVLLSLISFWSHLSIYLSIYLSIYLSIYLSIPISSLNNVDMLLNKTTNQPTNLSIYLSIYLSIYLSISDCPPPLVAGFQSHGDDLSQGSYTSSQNSSHLAPALLISFHLRWKTLHEAVLWHQTSQDHLHRHHKQYWRDGTSHSNTPLQLHIPCSVLRRRKTQYELIEVHSQTIPVSLRKDQPQNTLLPSVQLLGPPSKYVLIRYLSSSSRSTLNTPLVFSLNNCFVKRNGLSVNNFRALAAFCLFLASRSAILTLLMRFLMSSRIGLISSALCSSVRITAHYLRVSFFKAWMVLRRRLTCTGAKDLTFTSFNPNLVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ENE3</accession>
    <name>A0A812ENE3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_74395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005429">
        <property type="protein sequence ID" value="CAE1324712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ENE3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1324712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="389" mass="47405" checksum="9210518B9AFD4EBC" modified="2021-09-29" version="1">MCLSFIFILLLFSHFTILILFFFIFPFVFISTSIIFLLLSSSISSYISSFFFYIFLFPSPFFLFFFLLYFSISVSLFSFFFPSIFFYFRLPFFFFFSFYIFLFPSPFFLFFPSLFFYFRLLFFFFFPSIFFYFRLPFSFFFLLYFSISTSIFSSSFLLHFFHFYRYFFFFFSFCFFYFYNYFFSTSVSFSFFFFYSIDSFLSLFFHFSAILFLLFIFPSSFLPSPTTITSIFSDFLTSLPFTYSLSSSLFNFFFFLICFCFFLFFCLTIFQNFSYFSLSIFLQLQPFFFFFKFLLFLPFSFLAFFLLPLLFQIFLHFLPICLSFFSFILFWFSSFHFSSFPSSFISPASSSCIKCKNKPTAGITRLLPEQRTFPSSFLLLFPKYSKFFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ENP0</accession>
    <name>A0A812ENP0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_79123</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005558">
        <property type="protein sequence ID" value="CAE1329712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ENP0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="380"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1329712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="405" mass="49276" checksum="70D04CA7F5AB02DF" modified="2021-09-29" version="1">MTTPRSSPRYSALSLRKIEIREVATGFPTRGHFSYIPRYPFHSFFLSFFLFLSFFLISIFSILSFLLVSFFLSFFLSFFLSFFLSFLSVSFPFFLSFFLSFFLFFSFFFFSFFFLSFFFLSFLSYQYLFPFFFLSFFLSFFLSFLSFFLSVSFPFFLSYQYLSFFLSFFLSFSYQYPFPFFLSFFLSFFSFFLSFFLSFFFLFHSFFLSYQFFPFFLSFFLFFSFFLSFLSVSFFHSFFLSFFFFLSFFLSFFLSYQYLFHSFFLSFFLSFFLSFPLSFSLSLSFLPFFLPFIFLSFFLILSLSFFLSFLCDSIYLSIYLSIYLSIYLSIYLSLFESMYLSAATCSYMFIYINLSIYLSIHLSIYLSIYQIFPYRETVNIFLIYLSIYLSIYLSIYLSIYLSQPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ER14</accession>
    <name>A0A812ER14_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_75397</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005458">
        <property type="protein sequence ID" value="CAE1325802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ER14"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="321"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="416"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="442"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1325802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="493" mass="56536" checksum="7031643CD54A1A49" modified="2021-09-29" version="1">MVLSRPYDSLFSGRGFGGGHFVTIRQSLSLLSYFLYFSFISHLSISSFILSFPLFLSYFQSRSITFSTSPIFLSFFLSFFLPSFLSFTMSLFLSLSIYYVLTPSPIFLSFFLSFFLSFFLSFAISLCLSLSIHNVFFYQQVLFLFLSLSLSLSLSLFYLYLFQLDFLHFFLSSHPSHILFETNIRFVNIVLSFSLSLSFFRFSRLSLLFLSHPLLLTLSFFLSLSSYLSISLPLSHLSCFLLSISAPFLSYIHSVFIYFPTILFLFDHLFISLYLSLSHTHIDRHTHSLSLSLSLSLSLCHSLYHSLLFGVYLFLHCIFSLFLSLPLSSLVVSISLLFSLSPSLSLSLSLSLRHSLLLAITLSYLVCIYFSIIFSLFPPLSLSLLFGLYLFFRYFPFLFFSLSLPLSPSLSLSLSLSLLHFVSIFLLISVSLFLTLPNNLSYLYIFFISFSLSFPSPPSHCALFSSPLFPVSLFRYLCTNTRRYNAVIKRDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ERT3</accession>
    <name>A0A812ERT3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_79176</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005560">
        <property type="protein sequence ID" value="CAE1329773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ERT3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1329773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="197" mass="23060" checksum="B36C78F269EFAA4E" modified="2021-09-29" version="1">MTPSLSPSFLSLHKYKHLLTSKLNLLFLFLYDCLSILIDILFLTYSLSLSPQFLITTSSFKPFHLLFKLFAFLPLSYECPTSLIVTTHISSTLCHSFTPSRFILSPSFLFLTLISPHSLYIQFLPHTVDTSFYTSLLSCLYSSYIPLFLFILFSVIFIHSIFCHLHDISVYLKMFFHLLLDYFPFFSFLFSFFLIHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ES22</accession>
    <name>A0A812ES22_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_76425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005489">
        <property type="protein sequence ID" value="CAE1326887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ES22"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="319"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1326887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="345" mass="42079" checksum="4F7EA0779789FD27" modified="2021-09-29" version="1">MEEDDFFAFFISFLLSFFLSFFLSFLLSLFLSFFLSFFLSFFLSFFLACLLSFFLPSFLSFFLSLLISFSFFFLSFSLKYLVCFSLSFKKKYLLLLAFFLSFLLFFFAFFLFFLLFFSFLFFSFFLFFLSFFFFFFFLSFLLSFFFLSSCLSFFLSFFLPFFLSFFLSFFLSFFLSSTINFFLFLFSFFFFVLFITFSFFSSFIFFKYLLLCFSVSFLKKYLLQFLSFSFFNIIITVFLSLFFLSFFLSFSLIALFFFLSFFFLTFSLKYLLLCFSLSFKKILITISLFLLNTYYFFLSFFLSFFLFNTYNNFPLFSLRYLSSCSFFLSFFLSFFPDFYAFKTLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EUF2</accession>
    <name>A0A812EUF2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_80532</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005600">
        <property type="protein sequence ID" value="CAE1331310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EUF2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="338"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="432"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="463"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="489"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="525"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="556"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="582"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1331310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="606" mass="68802" checksum="57BC92B0D9528729" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EV63</accession>
    <name>A0A812EV63_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SPHA_80431</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005599">
        <property type="protein sequence ID" value="CAE1331239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EV63"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26392">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26392:SF92">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="434"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="465"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAE1331239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="774" mass="88561" checksum="13B282CD999D8356" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EW72</accession>
    <name>A0A812EW72_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">hypoxia-inducible factor-proline dioxygenase</fullName>
            <ecNumber evidence="7">1.14.11.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SPHA_80924</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Farmed</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-prolyl-[hypoxia-inducible factor alpha subunit] + 2-oxoglutarate + O2 = trans-4-hydroxy-L-prolyl-[hypoxia-inducible factor alpha subunit] + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:48400"/>
            <dbReference type="Rhea" id="RHEA-COMP:12093"/>
            <dbReference type="Rhea" id="RHEA-COMP:12094"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:50342"/>
            <dbReference type="ChEBI" id="CHEBI:61965"/>
            <dbReference type="EC" id="1.14.11.29"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.29" evidence="7"/>
    <dbReference type="EMBL" id="CAHIKZ030005614">
        <property type="protein sequence ID" value="CAE1331797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EW72"/>
    <dbReference type="OrthoDB" id="76265at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160082">
        <property type="term" value="F:hypoxia-inducible factor-proline dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071456">
        <property type="term" value="P:cellular response to hypoxia"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051559">
        <property type="entry name" value="HIF_prolyl_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12907">
        <property type="entry name" value="EGL NINE HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12907:SF26">
        <property type="entry name" value="HIF PROLYL HYDROXYLASE, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0847">Vitamin C</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="10">
        <location>
            <begin position="37"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="150"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="162"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAE1331797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="174" mass="20069" checksum="BBA9B60F6212F4E2" modified="2021-09-29" version="1">MIMWMDGNEENCENIKLLMECVDRLVLLCKGKLGSYNINGRTKGMVACYPGNDTKYLRHIDNPNADGRCMTCIYYINKDWNVETDGGLLRIFPEGQETVANIVPKFDRLLFFWSDRRNPHEVQAAKRCRYAITVWYFDAEERAAAMKRLSGQNNNNNNNNNSGSKNLTNQTNKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EYU4</accession>
    <name>A0A812EYU4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_79628</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005574">
        <property type="protein sequence ID" value="CAE1330309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EYU4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1330309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="334" mass="36524" checksum="1475DF34133B1262" modified="2021-09-29" version="1">MDSTEDNKKKTRESFGIFSWATKAVAVGCPLAAVLGAPLTSATTTALTIPTATCYHHSPTIYHHKPYYSKLTTTALTIPTATSATTTAQTATTYSHGNLLPPQTILFPRQLPQPLLFPPHSHLLPPQLTNRNFATTTALYYSHRNFAITIPTATTTALTILLPPTPLNLFPTIPTATTTVLLVFHGNCYYSRNSPYYSHRNLLPITDYSLLPPQPLFIPTATSATTTALTIPTATSATTTALPTYNYSPLLFPIAASPTYSHCNFQHTTANSLLFPPHHHTPLPFPRQLPPQLFNPSRQLLLPPQPLFPLQLTIPTATTTALYYSIPTATCYNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AKM3</accession>
    <name>A0A812AKM3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000024">
        <property type="protein sequence ID" value="CAE1141538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AKM3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1141538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="208" mass="24873" checksum="E0D721B62F4AD8CE" modified="2021-09-29" version="1">MFVQRGFILFSRKSLLNFLSYTSLHIYLSIYLSIYLSIYAVTSHLSIYTRLFISINTILFIHTLVSSYLSIYLSYLSIYLSIFSSYLSIYLSIIYLSIYLSIYLSVHFISIYLSLYIYIYIYIYIYISDLCLFLSIYLSIYAGLFISIYLSIYLFIYLCWSLHIYLSIYVFTLVTSYLFIYLHSSLHIYLFIHTSQFISIYLSIYLFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AM30</accession>
    <name>A0A812AM30_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_1366</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000038">
        <property type="protein sequence ID" value="CAE1143787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AM30"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1143787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="213" mass="25097" checksum="8BF526C516F3E62E" modified="2021-09-29" version="1">MVTYLLVFSYRIHSGHYLYLSIYLSIYLSIYLSISSIMSVDIYLSLSLSHSLCLLIFIHILSIYLSIYLSIYLSIQLSLLFIYLSHLSIYLFNYRSVNILKFVYIYLSIYLCFCEYLKSIYLSISVHIYLSFYLYMSVCSNLSIYLSIYLSIYLCSYLSIFLSIYLSLLKSIYLSMCSKYVGRLFLFLFFINSIFSKNPKENMVLLVSIPLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812APB9</accession>
    <name>A0A812APB9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_2049</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000058">
        <property type="protein sequence ID" value="CAE1147065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812APB9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1147065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="296" mass="35517" checksum="9447E98F337606DB" modified="2021-09-29" version="1">MSALLFDNQTWEFSFLSFIHSFFLLLSFNSVIPLPFRPFQFFFFLLLISIFFHLKIRTLSFFFFVFYIFSSSFVTIFFHIPLNFFQTNILFIFNNSHCTFFLSFLLSFFLSCGSSFSFLYFFSILHAFILFLFSLMSFNLIFYSFIFNNSYFSFFLPFFFLSLFLLVFVFFFHFSFIQLNVFFIHFFIFFLFLSIQLNVFIIHFQIFPSFHIYYHYLFDNFHEVFPSVKIFSPLSCPSLIPFTRLVPLLIHSLVLSLLNFIHLSCPSLTSFPRLSHIYSIHSSCPSLISFTRLVPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AQC1</accession>
    <name>A0A812AQC1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_2584</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000072">
        <property type="protein sequence ID" value="CAE1148896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AQC1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1148896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="343" mass="39012" checksum="4E9FBB557453ABC6" modified="2021-09-29" version="1">MKKLVLSIRFYQNSFPKSPSLRGWGKDFVFSGSFLFLSISVGSLPISSCSYLSIYLSIYLSQSFHYRSLDLSQSVHIYLSIYLNLCLSIHPCLFLTRINLCISLSPSASLSLSLSLSLSLSLSLSLSLSLSLSDLTYSTALYLYLSIYLSIYLSMITCSLCMYVCMYLSIYHYLFITSIDLSIYLSQSVNIDLFYSNFLSIYLRLFTSIYLSIYLSIYLSIYLSMADLFLSIYLSFTGFSILSIYLSIYLSIYLSIYHNFSYLSIYLSNYGRVGAVDIKAICSLSIFQTITLYIYLSIYLSIYLSIYLSIYLSTYCPPSFSFSNASFAQLRATLKARSAFFDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ASP7</accession>
    <name>A0A812ASP7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_4321</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000136">
        <property type="protein sequence ID" value="CAE1154852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ASP7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1154852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="163" mass="18893" checksum="897545712F43B65A" modified="2021-09-29" version="1">MHIYVRNLFDLAFFMFCLNFVSIISIAFFFLFLFSFFSLSLSLSPALRSLSLSCSRFSLLPFFCYAPYFPSVSFPPYLSSHWLTTFLPRLYFPSLPPHLPHSFLTSPSGTIFIHLPSFSFLPIPSYPSPHRSSCKDLSLLDMREVKLFKLKEQMSSPLYSFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AVL9</accession>
    <name>A0A812AVL9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">STK38</fullName>
            <ecNumber evidence="9">2.7.11.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SPHA_5040</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Farmed</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="9"/>
    <dbReference type="EMBL" id="CAHIKZ030000168">
        <property type="protein sequence ID" value="CAE1157108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AVL9"/>
    <dbReference type="OrthoDB" id="3638488at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000393">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050839">
        <property type="entry name" value="Rho-assoc_Ser/Thr_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988:SF76">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_135, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988">
        <property type="entry name" value="MYOTONIC DYSTROPHY S/T KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="39"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAE1157108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="204" mass="23809" checksum="858A8326FDABBE61" modified="2021-09-29" version="1">MLKFFLFFSLQKSERRQQHAVKETEFLRLKRSRLGVDDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKIDMLEKEQVAHVRAERDILVEADHQWVVKMYYSFQDALNLYLIMEFLPGGDMMTLLMKKDTLTEEQTQFYVSEAALAIDSIHRLGFIHRDIKPDNLLLDARIISFLKPRLFAFSIDSDNISFLFPVNIGLSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AYS0</accession>
    <name>A0A812AYS0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_7337</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000236">
        <property type="protein sequence ID" value="CAE1162382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AYS0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="345"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="380"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="407"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="436"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="473"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="507"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="533"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="584"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="609"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="650"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="680"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="719"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="751"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="777"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="805"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="840"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="869"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="902"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="931"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="953"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="978"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1010"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1042"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1068"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1096"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1145"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1176"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1208"/>
            <end position="1230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1162382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1231" mass="148395" checksum="0ADF060C0894CB65" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AZK5</accession>
    <name>A0A812AZK5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="13">MYO3</fullName>
            <ecNumber evidence="13">2.7.11.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SPHA_9973</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="13"/>
    <dbReference type="EMBL" id="CAHIKZ030000319">
        <property type="protein sequence ID" value="CAE1168286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AZK5"/>
    <dbReference type="OrthoDB" id="2914378at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042995">
        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030832">
        <property type="term" value="P:regulation of actin filament length"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052409">
        <property type="entry name" value="Myosin-III_kinase_activity"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46256">
        <property type="entry name" value="AGAP011099-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46256:SF3">
        <property type="entry name" value="MYOSIN MOTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="24"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAE1168286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="215" mass="24793" checksum="19D85E3E749C4D7C" modified="2021-09-29" version="1">MLKMYSKYSKVIEFDKLTDPTQTWDLQELIGEGTYGEVYAVKNKQTGQLAAAKIMENIHETVEEIEQEYQILKAVSCHPNFPQFYGLYLKKDTKMDDQLWIIMELCTNGSVTDLSKDLVTQNRRMDEVLIAFILRETLKAINYMHKNHYIHRDIKGHNILMTNDGSIKLVDFGVSGLLKSTLAPRRTSVGTPYWMAPEVREFQSIIDNVYGTSDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B0C1</accession>
    <name>A0A812B0C1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ral GTPase-activating protein subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SPHA_7636</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000246">
        <property type="protein sequence ID" value="CAE1163323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10009983at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051056">
        <property type="term" value="P:regulation of small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11210">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039930">
        <property type="entry name" value="RALGAPB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035974">
        <property type="entry name" value="Rap/Ran-GAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000331">
        <property type="entry name" value="Rap/Ran_GAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046859">
        <property type="entry name" value="RGPA/RALGAPB_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21344">
        <property type="entry name" value="RAL GTPASE-ACTIVATING PROTEIN SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21344:SF1">
        <property type="entry name" value="RAL GTPASE-ACTIVATING PROTEIN SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20412">
        <property type="entry name" value="RALGAPB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111347">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50085">
        <property type="entry name" value="RAPGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1415"/>
            <end position="1434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1441"/>
            <end position="1461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1556"/>
            <end position="1577"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1583"/>
            <end position="1606"/>
        </location>
    </feature>
    <feature type="domain" description="Rap-GAP" evidence="4">
        <location>
            <begin position="1203"/>
            <end position="1473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="369"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="475"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="713"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="369"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="407"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="475"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="713"/>
            <end position="734"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAE1163323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1743" mass="196442" checksum="0525EB3D4D1511CC" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B130</accession>
    <name>A0A812B130_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_8354</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000270">
        <property type="protein sequence ID" value="CAE1165153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9942939at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050938">
        <property type="entry name" value="Collagen_Structural_Proteins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37456:SF6">
        <property type="entry name" value="COLLAGEN ALPHA-1(XXIII) CHAIN-LIKE ISOFORM X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37456">
        <property type="entry name" value="SI:CH211-266K2.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1165153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1296" mass="144823" checksum="855AB6817F4DDFA7" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B213</accession>
    <name>A0A812B213_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_9194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000294">
        <property type="protein sequence ID" value="CAE1167017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B213"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1167017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="309" mass="36863" checksum="D0EDC2F482BF3248" modified="2021-09-29" version="1">MFITIQSVHIYLSIYLSIYLSIYLSITVICKLRIRRDSQGSFHICQSTVLFMTFSKSLYSGSSFLSSIIISSFLSFFYRSLFPYTSFFYFLFVCFFLSLAPTTSFFSTFFLSFLPSFFLSFFLSFFLSFFLTTFLFSFPFRFHSFFISLFPTTSFFHSSFFFYSFILSFYSTTSFFAIPFLSFFLSFFLSFFLSFFLSFFLTHYFSFFFLSLFSSFYFLSTLFLFSIFFLFIFLITSFLTFLSFFLSFFLSFFLSFFLSFFAVSHPLTSFFLCYISPPLSFSCFFTFFILIIYICYPPPLPHKMPESIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B2K7</accession>
    <name>A0A812B2K7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_9522</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000302">
        <property type="protein sequence ID" value="CAE1167421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B2K7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1167421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="294" mass="34766" checksum="4DEE5B1CC6595D6E" modified="2021-09-29" version="1">MSLSLLASKESTAASVYYITIYPKLFIIYLSIYLSIYLSIYLSIYLSESVHYLSIYLSIYLSIYLSIYLSIYLNLLLSIYLSIYLSIYLSIYLLSSLTKTEQQASENFYYRRCRHNLLSFLSLFFLAFPFDSYLFIYLSIYLSIYLSIYLSIYLHASQAIYLSIYLPSFMTHMYICSYLCMYLSIYLSIYLSIYLILFCLSVLRLSIYLSIYLSIYLSIKFCSSSIFLCLSVQYLSIYLSIYLSIYLSIYLSIYLSLFIIYLSIYLSIYLSIYLFNSVFLCMYVCLYLSIYLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B2U0</accession>
    <name>A0A812B2U0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_9816</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000313">
        <property type="protein sequence ID" value="CAE1168040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B2U0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="330"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="382"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="422"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="457"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1168040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="476" mass="56625" checksum="D14AD562000D7702" modified="2021-09-29" version="1">MYLLILFHIYIFCSLISIIYLSIYLSSSCYFFSFFVSFFVSFFPSLFISIYLSIYLSIYLSIYFHSVLSVILFVCLFPSFFLSIYLSIYLSIYLSVTMSVSFHSFFLSFFLSFFLSFFLSMILICFYIFFPFLFLSYINSFFLFFLLHSFIILSFFLFLHLICFFILHPFLFLSYINSFFLSFFLSFFLSFFLSFFLSIHSFFLSFHSFFLSFFLHSFILSFLFLSFFLSFFLSFFLSFFIHSFINSKITDAIKLKLRSRFQDCPPHTHTCASAHTHLYALLISIYLSIYLSIYLSIYLLLKLSLSVARNLKQKINHWTKDKNENESIYLSIYLSIYLSIYLSLTLFSLFFLPFFLSSDSPFLPYSYSTDEMLGDWSGMGEVTVFFLFFFLSFFLSFFLSFFLLNIFLLFRARFIVIPNDDVRWTGCICGCTSNSLAYTYLFIYLSICLPMSKFKYLSIYLSIYLSIYLFMCMSGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B4Y2</accession>
    <name>A0A812B4Y2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_11087</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000365">
        <property type="protein sequence ID" value="CAE1170487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B4Y2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1170487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="276" mass="31904" checksum="DB13F8ADB9887C75" modified="2021-09-29" version="1">MIPTSALHHILLANASTRPTQYALSTIHFALAKPDVIPSFFLSFFNSFIFLSFFNFLYSSIFPFLSLCLTSFPIFTDIFSFFLFSPIYLSIYLSIYLSIYRHLRSYLSIYLSIYLSIYLSIYSIYLSQSVHFYLSQSVHIYLSIYLSIYLSIYLSIYPAINLCLSLCLFLPIVSFSLSIYLSIYLSIYLSIYLSICLLKSIYLSIYLSIYLSFATICVSLSSPLSICPIIFLFNNFIPFFTFLSLSLIACRFVFFFLSLSSTHFSLWLSLSCHSFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B6I7</accession>
    <name>A0A812B6I7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_10100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000325">
        <property type="protein sequence ID" value="CAE1168564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B6I7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="301"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="323"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="351"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="387"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1168564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="415" mass="49714" checksum="5DEBDDFE835D2CDA" modified="2021-09-29" version="1">MTLSSFLPSLGVFFSFFLSFFLSFFLSFFLSFFRAIFLSFFLPDNLRSTTFLSLSFFIPFPCFFYRSSLLYRLVQHHLGHIDLSTYIHTSIYLSIYLSIYLSIYLSIYGRHGGSMDVSSICLTHICLSLFIYQHFNIYLSIYLSIYLSIYLSIYFYQNISRSIYLSIYLSIYLFMSIFISVFPDLSIYLSIYLSIYLSILVCSYLSIYLSIYLSIYLSNRLFLFEYFHIYLSIYLSIYLSIYLSIYFRFYLSIPHLSIYLSIYLSISIFIRVFPDLSIYLSIYLYLSIYLCLLISQHFPIYIFMLVSITSFFFINFFYSFSFIFFIISSFILSFFFILSFILYFFFISSFILSFSLLFLLLFSLFHLSHFLFHAFHTFPTVCRYPSLFTYLSIYLSIYLIYLATLGIWPDIFLFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B7Q2</accession>
    <name>A0A812B7Q2_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SPHA_12389</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Farmed</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the p23/wos2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000415">
        <property type="protein sequence ID" value="CAE1173015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B7Q2"/>
    <dbReference type="OrthoDB" id="249932at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045250">
        <property type="entry name" value="p23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22932:SF1">
        <property type="entry name" value="CO-CHAPERONE PROTEIN DAF-41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22932">
        <property type="entry name" value="TELOMERASE-BINDING PROTEIN P23 HSP90 CO-CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="3">
        <location>
            <begin position="285"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="428"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="432"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAE1173015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="469" mass="53310" checksum="71D337FF81BFB43C" modified="2021-09-29" version="1">MLSYLKDCLNYPEKLIEENVPDSILKCLTYTQDPDQFSLIVDAVKVLISTPSLLDNLMSCGILQSLGQILKMNDDVSILHTAIQLIQFMTENNTSLLKPIASLKSGLFSILCEIVKGVYQNEIRTSVCHLLESFCLADEKCTENLIQFQVCPICLPNVLEIQDHDFTEAYLSLLVPVSLLDSGLVAIKREKPIEEIMKIVAAATCEKCVYKCLVALKRLADKSRKNKTLLLELNAIAIFSSCQNLLKNTEVATLCQDLLDGLLVKVNHNQDNKITVRTLQHPTIENNFQVFWCQNKFRLLLTVKLNNSEWSGCKFHKTSVHFSFVLNDGVKQTVDYELFDEVVVEKCAVCIQNNEIILSFCKAEFEYWPRLLQDKYKPTNLHVDFDKIVDSDDSGSEEVEADEENLFTLQVVVKKPLIKLKKLSSCDVDEEAEKKDPLPVDSAKSDEDSLENSDFEEYDRFNIFNTKYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B8H6</accession>
    <name>A0A812B8H6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_12917</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000432">
        <property type="protein sequence ID" value="CAE1173959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B8H6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1173959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="218" mass="25782" checksum="498D679D5F8E0891" modified="2021-09-29" version="1">MGLNTPFTISASGSPGELCTIFDTNFRLLLFAPIYLSIYLSIYLSIYRSWFIIYLSIYLSIYLSIYLSQFFYLSRSVSIYLSIYLSIYLSIYLSIYLSLFISPPPYLSIYLSIYLSIYLSQSVYLSLSLSIYLSVHIYLSIYLSLFISIHLFIYLSIYLFYSVDLSIYLSIYLSIYLIIYCYSQNINIYSNLLPLYFPFMFSFLIFPFHIRFLSKNLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B8Y3</accession>
    <name>A0A812B8Y3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_12316</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000412">
        <property type="protein sequence ID" value="CAE1172920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B8Y3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="281"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="311"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1172920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="348" mass="40941" checksum="3956A6E4CA56CB61" modified="2021-09-29" version="1">MEDIEFLSSNNFYQPQPCNISHSLQWHTQVFSFTNVIPKISIAGCFYLSIYLSIYLSIYLSIYIYIYIYIYISFIIYLYLYIFCSYLSIYLSIYVHYLSNVLYLSMFIIYLSIYLSIYLSIYLYIHSISIYLSIYLSISVCANLSIYLSIYLSIYLSIYLSISVCPNLSIYLSIYLSIYLYIYLSIYLSKSFHIYLSIYLSIYLSQTLHIYLSISDYSYLSIYLSIYLSIYLSLSFHVILSVCLGLFISINLSQLSISICLSLLSSIYLSIYLSIYLFSSYLSIYLSIYLSIYLSIYLSQHNDDCVWNETFIFICIHINLFISIYLSIYLSQLFITVYLSVCSYLSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BC17</accession>
    <name>A0A812BC17_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_16995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000602">
        <property type="protein sequence ID" value="CAE1228878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BC17"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1228878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="208" mass="24530" checksum="F3D0BB139FE75A65" modified="2021-09-29" version="1">MFLFSGFVFECFLFSLFLLPFPLSFFLSFFIYLLPSSLSFFLLCLPPFLNSFFSSFLSAISFFLPTIVSFFLSFFLSFIPFFLSLFPSFLPLSFCYSFLSFFLSFFFLSFFLSLLPPSLSFCYSFLPSLLPSFLLPKSFLFVLYFFLILHISSFFLSFFLSFTYFDVSLHLTVIYKDITDSPFLSIYLSIYLSIYLSMPIHIYDYSYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BCX2</accession>
    <name>A0A812BCX2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_16054</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000560">
        <property type="protein sequence ID" value="CAE1226487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BCX2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1226487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="153" mass="17715" checksum="EF7AA33BA5B31450" modified="2021-09-29" version="1">MGEFLVAKAHMVFLSHYWTASKTAASRKPISSIFFLSLVNQLSFLVSFFLNMSLFLFFFQLINIIFFVSSFFSAHRFSICLFLFFIFSVLFVFLFTIFFYNSPVFRLYLFSSIILFSLVDYLSFKSFVFILNSHSLSLSLSLSLSLSLSLSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BE91</accession>
    <name>A0A812BE91_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_15863</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000555">
        <property type="protein sequence ID" value="CAE1226075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BE91"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="343"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="411"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="437"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="478"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="508"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="543"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="571"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="602"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="632"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="665"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="693"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="724"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="754"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="783"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="813"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="846"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="873"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="898"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="922"/>
            <end position="942"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1226075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="960" mass="113044" checksum="972B0FE513AF61BD" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BGA4</accession>
    <name>A0A812BGA4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_16996</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000602">
        <property type="protein sequence ID" value="CAE1228756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BGA4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
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        </location>
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        </location>
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        <location>
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            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1228756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="469" mass="55759" checksum="7C7BE6F00D4BA572" modified="2021-09-29" version="1">MYLSISLSYIYLSNFIIIYLSISLSFFLFLYFFLSSILSIYLSLSIYISISVYSYISISVHSCVCMYLFLVFYLSIYLSIYLSIFFFPIFSYLSIYLSQFVRIYLSILLSIYLSIYLFVSVPIYLSIYLSIYLSIYLSSLSIYLSQFVLSIYLICSYLSISYLSIYLSIYLSIYLSVSFSLYLSFFLSFFLFSLFFQLKSYFSFYISSTYHTFFLSFSFFLSFFLSFFLSFFLSTYFHTIYLSIYLSIYLNLFKLFFLSLNCSISIYFQISSFIIYLSIYLSIYHSRLIYLSIYLSIYLSIYLSISVRSLSIYLSIYLSIYVFLCIVVIYLFIYLSSLFLSVYLILLSIYLSIYLSIYLYLSIYLSIIRYLSIYLSISSIYLSIYLSIYLSQSVHYYLSIYLSISIYLSGIYLSIYLVGIIYLSIYLSHRFIILSIYLSIYLSQSVHYLSIYLSIYLSIYLSQVSFYLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BHI8</accession>
    <name>A0A812BHI8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SPHA_17664</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Farmed</strain>
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        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
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</entry>
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        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000759">
        <property type="protein sequence ID" value="CAE1237267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BMW8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1237267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="173" mass="20455" checksum="C6997DF516B4A582" modified="2021-09-29" version="1">MITYFFLLHPYNNHLPYPHNDHLLSFILTSFHIPHKPPSNILIMITYLLFSYILTTTTFHILIMITYFFLLRPYNNNLPYPHNDHLLLSLTLQQPQSTYFLSYILTTTTFHILIMITYFFLLHPYNNHLPYPHNDHLLSFSDTSLSNNNLPYPHNDHLLLSLTSLQQPPSISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BN74</accession>
    <name>A0A812BN74_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TPCN3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SPHA_19730</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000717">
        <property type="protein sequence ID" value="CAE1235318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BN74"/>
    <dbReference type="OrthoDB" id="10068803at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005216">
        <property type="term" value="F:monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46726">
        <property type="entry name" value="TWO PORE CHANNEL 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46726:SF1">
        <property type="entry name" value="TWO-PORE CALCIUM CHANNEL 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="250"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="400"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="426"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="451"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="506"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="545"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="6">
        <location>
            <begin position="57"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="6">
        <location>
            <begin position="398"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAE1235318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="655" mass="77936" checksum="5A236F81A4F33CF9" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BNP5</accession>
    <name>A0A812BNP5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_22258</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000822">
        <property type="protein sequence ID" value="CAE1240338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BNP5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="281"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="311"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="362"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="400"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="438"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="472"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1240338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="543" mass="64739" checksum="575C673ACD86BAEB" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BP62</accession>
    <name>A0A812BP62_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_21383</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000784">
        <property type="protein sequence ID" value="CAE1238600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BP62"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1238600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="160" mass="19188" checksum="DF1CCC21195A0B81" modified="2021-09-29" version="1">MELRSHFFSVPLPSQICLISTSLSLSLSLYLSIYLSIIYLSIYLSIYLSIYLSLSLSLSIYIYIYIYIYIYIYMHKVYVGISLLSFFLYSPLFAFIILTFFREYFIIIFFLVSFVFLLIFFVLSFLFIPSLYRYLLFPLSLFVAIFTMLFSKIWTYFCLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BSI9</accession>
    <name>A0A812BSI9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_24486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000913">
        <property type="protein sequence ID" value="CAE1244855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BSI9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1244855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="306" mass="36473" checksum="50E237BA238BE091" modified="2021-09-29" version="1">MTYELHFFFIKIVKCSSRVNYLSLSLSLSQHYLSIYLSSYKEVLIQMDSFLSFFLSFFLSFFLSFLHPSVCISISFVPQFLSLYISKATHTVFLFLRDQLTPLFFYFFFFFFFLVFFLSSFFPSILSLIFRHCSSFDFLFPKIIVPFAFSLSFSFFNISLVVLSRLHFFFYHNGFQHHFLFFLIFHLALHFSQFFSFNFVFSSLISTSFFFLFLFFPFIPFLHYFFLLSFVFFVSLNLYLLSSNFSHFLSLSSFLIFDSFSSSSTTTTTTVLITTDSFTIVSLNYFLLHFHFSLALQILIRLYYSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BSZ6</accession>
    <name>A0A812BSZ6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_26329</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001004">
        <property type="protein sequence ID" value="CAE1248806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BSZ6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="315"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1248806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="349" mass="42337" checksum="605E1CD99DA4EFD9" modified="2021-09-29" version="1">MYYLFVFLLPFFLSFFLSFFLSFFLFFLFLSFFLCFSFLLNVLYFCFPSPILSFFLSFFLFSFFLSFFLFKFYFFVFLSHFFLSFFLFFLSFLFKCIIFLFFLPFFLFFLSFFFLSFFFLSFKSHISSLHFFLSFFLAFFLSFSQPVFDFPLRPSPLFEYIFLFFLCLSFSFLPSFLPSLYSIIHTLFSAPFLLYFISVYSFIFEIYRQSLLLIFILVIKLKAFSFFFPCENAKPNILDQFLDFYLLIGVNLFIYPSDSLSLSRFLSLSHTDSQYMSIYSFSLFISIYLMLSTFRSFFLSFFLSAYLSFYLSEALHFFLSFFLSFFLSFFLSSYLSFYLKLPTSFFLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BTJ4</accession>
    <name>A0A812BTJ4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_22516</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000834">
        <property type="protein sequence ID" value="CAE1240839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BTJ4"/>
    <dbReference type="OrthoDB" id="1421090at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1240839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="262" mass="31506" checksum="1EABE3A09F2D7232" modified="2021-09-29" version="1">MSFSFQSIYLSIYLSIYLSIYLSIYFSLFFIYLSIYLSIYLSIYFSLFFIYLSIYLSIYFSLFFIYLSIYLSLIIYFIVCFYLSVFHRLFLSIYLSILHNLFQSIYLSKSVSIYLSFKVCFYLSIYLSFKACFYLSIYVSIFIICFNLSKFHHIFHNLSLSILHNLLQSIYLSFIIFCFYLSIYLSIYLSKSVSIYLSIYLSIFQSLFLSIYLSIYLSFKVCFYLSIYLSIYLSIYLSIFQSLFLSIYLSIYLSIYLPMYIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BU45</accession>
    <name>A0A812BU45_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_25407</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000961">
        <property type="protein sequence ID" value="CAE1246936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BU45"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23304:SF189">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23304">
        <property type="entry name" value="SPOT2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1246936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="265" mass="31800" checksum="1CDCD26235D7B4F2" modified="2021-09-29" version="1">MLHQKHTDNQSVWFGLRHTNLNVLFNADKSFIFGNIFFLSFFLSFFLSFFLSFYLSIYLSIYLSQVLLLVIFFIYLSIYLSIYLSIYRSIYLFFLQKYIADKREKKELARGVFRILCLCQLFQGNFPQRYWIVVEARGQKPCLRRSCSFFFFFLAFVIRNLLISIYLSIYLSIYLYLSIYLSQSYLLSISIYLSIYLSIYLSFINHIYLSIYLSIYLSIYLSIYLSIYLSISINHIIYLSIYLSIYLSQSSHIYLSIYLSICFHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BUK9</accession>
    <name>A0A812BUK9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_23904</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000887">
        <property type="protein sequence ID" value="CAE1243618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BUK9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="295"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1243618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="328" mass="39294" checksum="F5BC6D564D43DC6E" modified="2021-09-29" version="1">MTWLLFFSFLSFFFFFFLFLFFFFLLLFFLFLLLFSSSFFLFSPSFFFSFFILSFYLFFLFIFFLLLFFLFSFFSFFSFSFSRFRFFLFFLFSLFLFFPLFSLLSSFFSFSLFCFICFSLSLSLSPSLSLSLSSQTLGKRDICSILRNFHSLFNSLSFRPTFSLRATTNDFITTNTLHFLHPLSHSSLNAFNFRHISFCIMTSISFFYQLLFSLCFASLFPFFFSSSFSHFSLFLFIFVPFLSPFLFLFSFFSSFLSFPLSFLFFSSFFSSFFSFPLSFLFLFLFFSSFLSSSPFLLPLFFSFHIVFFRCLFLLMFSSFVFASIDRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BWV9</accession>
    <name>A0A812BWV9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_23634</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="component" value="Unassembled WGS sequence"/>
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            <end position="136"/>
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    </feature>
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            <end position="95"/>
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    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1243119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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    </protein>
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        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
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                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BXQ7</accession>
    <name>A0A812BXQ7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">SPHA_27448</name>
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    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
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            <authorList>
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                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">Farmed</strain>
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    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="component" value="Unassembled WGS sequence"/>
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            <begin position="118"/>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="159" mass="18695" checksum="D11AA214016C85CA" modified="2021-09-29" version="1">MKRFISIYLSIYLSIYLSIYLSIHQSGCMNIERKNWKSDNIAARYHFHSFSYFSSLSLSLTPPSPLSPSLSQCTRLPELIRSIASFFFLNIFHSYNTYDPFQLISVSLSPLLYRSPFSFLLSFFLFFLSFFLSFFLSFFLFLYFSLPLSNINIFPSYVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BYP2</accession>
    <name>A0A812BYP2_ACAPH</name>
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        <recommendedName>
            <fullName evidence="4">Dynein heavy chain</fullName>
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    <organism evidence="2 3">
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1246840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1772" mass="210560" checksum="EDAB67B005515110" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C0G3</accession>
    <name>A0A812C0G3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_28947</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001146">
        <property type="protein sequence ID" value="CAE1254427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C0G3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1254427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="313" mass="35584" checksum="9D289344EB4FDC1B" modified="2021-09-29" version="1">MSRLRTSIEPAPSTCLCCVPVSNQLPLHVPGAYRYLTSSLYMSRLRTSIEPALSTCPGCVLVSNQLPLHVPGAYQYLTSSLYMSRTPLFSPSLSLLFTLSRSSLSFVRIDRFIYLRRLSFSVANFVTLFKSIRFCSLVSNTISIYLSIYLSIYLILFMFIYLSISVHVHLSSYLSLLALCSLSISVDSISIYLSIYLFGGPHNTIYLSYLNVPINLSILICFYLFVCLSFSHSLSIYLSIYLSIYLSLSIIYLSIYLSIYLSIYLSPFYIYLSIYLSIYLSIYLSISVIFISIYLSIYLSIYLSIYLSISMSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C0V4</accession>
    <name>A0A812C0V4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_26234</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001001">
        <property type="protein sequence ID" value="CAE1248588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C0V4"/>
    <dbReference type="OrthoDB" id="5917548at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1248588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="287" mass="32279" checksum="2CEA113F9A8C6CEF" modified="2021-09-29" version="1">MNFHDLSHVCDYLLGLRCSHYSFHVCDAPKMKTVLYLDAYLHSWIFYLENYPNAYCESSPRLSRESPPRLSRKSPPRLSRKSPPRLSRKSPPRLSRESPPRLSRESPLRLSRESPRFFHLSQSSQCLHRSLESPLYLCLSRDTSHSRFLSLESSLSFLFSFELSRSRRRSLDSATLPRIFPLLLSRSLPSLSESVLNLHSLSFSPLNLPAHSVFPLNLPAHSVSPLNLPAHSVSPLNPPAHSVSPLNLPAHSVSPLNLPAHSVSPLNLPAHSVSLLNLPALFALLCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C3H8</accession>
    <name>A0A812C3H8_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Hepatocyte growth factor receptor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">HGF/SF receptor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Proto-oncogene c-Met</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Scatter factor receptor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Tyrosine-protein kinase Met</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">SPHA_27776</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="27">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the plexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="27">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001089">
        <property type="protein sequence ID" value="CAE1252020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="125363at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002116">
        <property type="term" value="C:semaphorin receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017154">
        <property type="term" value="F:semaphorin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030334">
        <property type="term" value="P:regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000554">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031148">
        <property type="entry name" value="Plexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002165">
        <property type="entry name" value="Plexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016201">
        <property type="entry name" value="PSI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001627">
        <property type="entry name" value="Semap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036352">
        <property type="entry name" value="Semap_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041019">
        <property type="entry name" value="TIG1_plexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22625">
        <property type="entry name" value="PLEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22625:SF70">
        <property type="entry name" value="PLEXIN A, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01437">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01833">
        <property type="entry name" value="TIG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17960">
        <property type="entry name" value="TIG_plexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00429">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00423">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101912">
        <property type="entry name" value="Sema domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51004">
        <property type="entry name" value="SEMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 23" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="14 24" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 23" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 24" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 24" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="15" id="KW-0829">Tyrosine-protein kinase</keyword>
    <keyword evidence="12" id="KW-0832">Ubl conjugation</keyword>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="290"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="327"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="412"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="444"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="477"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="515"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="549"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="582"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="610"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="634"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="660"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="692"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="720"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="744"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="776"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="807"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="840"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="924"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="952"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="980"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00033117"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00033136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00352"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51004"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAE1252020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="2272" mass="258902" checksum="16E1B44FAB1E2C5D" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C6T5</accession>
    <name>A0A812C6T5_ACAPH</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
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            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">Farmed</strain>
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    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </dbReference>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="668"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAE1261424.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="731" mass="80460" checksum="E959A0005427A85E" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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    <name>A0A812CCQ4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001515">
        <property type="protein sequence ID" value="CAE1266743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CCQ4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="398"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="427"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="472"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="496"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="526"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="563"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="596"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="619"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="722"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="749"/>
            <end position="771"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1266743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="779" mass="88639" checksum="E78DD62E90956D58" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CE75</accession>
    <name>A0A812CE75_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">SLC25A20_29</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SPHA_34254</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001447">
        <property type="protein sequence ID" value="CAE1264456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CE75"/>
    <dbReference type="OrthoDB" id="14252at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015227">
        <property type="term" value="F:O-acyl-L-carnitine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902603">
        <property type="term" value="P:carnitine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006839">
        <property type="term" value="P:mitochondrial transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000051">
        <property type="entry name" value="Mitochondrial carnitine/acylcarnitine carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF4">
        <property type="entry name" value="CONGESTED-LIKE TRACHEA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="87"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="187"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAE1264456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="281" mass="30826" checksum="905C8CD38E8CC313" modified="2021-09-29" version="1">MCVVVTGHPLDTIKVRLQTMPKPSPGMAPLYKGTWDCAMKTVRKEGFFGLYKGMAAPLAGVTPMFAICFFGFNVGKELQQKHSGDKLSYLQYFNAGLLAGVMTTVIMAPGERIKCLLQIQADSKTAPKYKGPLDCAAKLFKEGGIRSVYKGTGATLLRDMPASGMYFMSYEWMQNMLTPKGGNRNDLSPLRTLVAGGTAGIFNWLVAIPPDVLKSRYQTAPEGTYPNGIRDVFRHLMKEEGILAMYKGVTPVMLRAFPANAACFLGYEVTVKILDWLAPNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CEW4</accession>
    <name>A0A812CEW4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_33561</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001406">
        <property type="protein sequence ID" value="CAE1263111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CEW4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="311"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="383"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="407"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="454"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="489"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="522"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="556"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1263111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="585" mass="70536" checksum="D1F3BC7D721F9AEC" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CGD1</accession>
    <name>A0A812CGD1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNAH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SPHA_37114</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001646">
        <property type="protein sequence ID" value="CAE1271152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CGD1"/>
    <dbReference type="OrthoDB" id="286107at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.20">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041466">
        <property type="entry name" value="Dynein_AAA5_ext"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042228">
        <property type="entry name" value="Dynein_linker_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46961:SF15">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46961">
        <property type="entry name" value="DYNEIN HEAVY CHAIN 1, AXONEMAL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17852">
        <property type="entry name" value="Dynein_AAA_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein heavy chain hydrolytic ATP-binding dynein motor region" evidence="2">
        <location>
            <begin position="177"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain hydrolytic ATP-binding dynein motor region" evidence="2">
        <location>
            <begin position="229"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain AAA 5 extension" evidence="3">
        <location>
            <begin position="556"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAE1271152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="645" mass="73029" checksum="CB9D29880EE568BB" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CGM0</accession>
    <name>A0A812CGM0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_33856</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001424">
        <property type="protein sequence ID" value="CAE1263640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CGM0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1263640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="178" mass="21170" checksum="1294C4CFF1A9061B" modified="2021-09-29" version="1">MNIYLSIYLSIYLSIYQIPGVRIIHYTYNNSFFFFLFLFSNGPPPQRHTPVFYLRCIPAFSVSFDSTIASKNTPFPLGHLSSSPLTRGGRVSNLFVHFSFLVCVCVCFSLFRSLLSFSFFFFFYSFIIFFHFFILSFSFFYYFLSFLHAFLLSFCPVFYIDFSFCFFSIFFLTLYFPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CHL7</accession>
    <name>A0A812CHL7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_34351</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001455">
        <property type="protein sequence ID" value="CAE1264746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CHL7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1264746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="225" mass="26135" checksum="647D21AC5C699C2B" modified="2021-09-29" version="1">MFADLSFQITPEKIIAAGGRNRYADIYLPIYLTMLISTYLSHILISIYLSIYLSILISIYLSQYADIYLPIYLSMLISISYPDIYLSIYLSIYLSQHTYIYLPIYLSMLISIYLGILISIYLSISYADIYLSIYLSIYLSIYLSISSAGIYPSIYISIYPCILFIYLSIYLSIYLSIYLSVCLSYADIYLSQYTDIYLSIYLSIYLSIFLSHILISIYRSMLISF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CI04</accession>
    <name>A0A812CI04_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_35200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001512">
        <property type="protein sequence ID" value="CAE1266507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CI04"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1266507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="179" mass="20768" checksum="6086D5DC31083DD3" modified="2021-09-29" version="1">MLGIYLPIFGQYLSISPPSLSLSLSLELSVSTISVFSFSLSMIIQKLLFIYISIYLGFCPYLSIYLSIYLSMYICFVSICSIGKTKLSYFLGSQSDLQSPAHISEIPDILFVFCPYLSIYLSIYLSIYLSIDVYLFCQYLCMHIWSISTYLFIYPSVVFIYLRFFIFLCLSVQWKKEYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CJA0</accession>
    <name>A0A812CJA0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_38561</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001757">
        <property type="protein sequence ID" value="CAE1274035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CJA0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="313"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="402"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="460"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="491"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="516"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1274035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="547" mass="65595" checksum="6CC9D1137C20916D" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CJD1</accession>
    <name>A0A812CJD1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_34781</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001484">
        <property type="protein sequence ID" value="CAE1265635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CJD1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1265635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="298" mass="33466" checksum="D868301DCBF66FB4" modified="2021-09-29" version="1">MQPTRSIYIYLSIYLSIYLSITVNVFVSIYLSIYLSIYLSITIYLYIYIYIYIYVCVCVCVYHSLFIIYLSIYLSIYLIVRGSPPTAPPRFTFDSSLPITQRPTTTEDETSSRYFINGSEILPCTDPTPGPSPPPHCAPPRPVPPLGVGKLINSFLSDFFTFCFFILLMTKPWSSNSKFRSGRYTHIITLSPPLSLFLSLHLSPSLSFSLSPLFPLSFGEISPLSLSPSPLSPSFSPPLFLSPFLSLSPSLPLSFSLSLDPSWSKRAFSRVLKLYAETKSFFFLFPSLSLSLSLLTQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CK27</accession>
    <name>A0A812CK27_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_35110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001510">
        <property type="protein sequence ID" value="CAE1266383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CK27"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1266383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="160" mass="18830" checksum="901F5BD20B6A024D" modified="2021-09-29" version="1">MLHSYQEAGHWRQIESMMHSYQEAGHRRQIESMLHSYQEAGHWPQIESMMHSYQEAGHRRQIESMMHSYQEAGHRRQIESMMHSYQEAGHRRQIESMLHSYHEAGHWPQIESMMHSYQEAGHRRQIESMMHSYQKAAIGAKSSLCCILIKKLAIGAKSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CMT1</accession>
    <name>A0A812CMT1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_40354</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001902">
        <property type="protein sequence ID" value="CAE1276940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CMT1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1276940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="223" mass="25511" checksum="7D57370BBC67DE75" modified="2021-09-29" version="1">MTSFDLKNIYLSIYLSIYLSIYLGSVVLIEKIFSPSIYLSIYLSWICFNRKQIFISIYLSIYLSIYLGFVVLIEKSKSIYLSIYLSWICCFNRKNILSLSLSLSLSLCKNINLSIYLSIYLGSVVLIEKIFSPYIYLSMYLGSVLIENKYSYLSIYLGSVALIEKSINLSIHLGSVVLTEKYPLSLSLSFSLSVSLGSVVLIEKVIYLSIYLSIYLSLICFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CN31</accession>
    <name>A0A812CN31_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SPHA_37552</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Farmed</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ELP4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001673">
        <property type="protein sequence ID" value="CAE1272150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CN31"/>
    <dbReference type="OrthoDB" id="289162at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008728">
        <property type="entry name" value="Elongator_complex_protein_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12896:SF1">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12896">
        <property type="entry name" value="PAX6 NEIGHBOR PROTEIN PAXNEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05625">
        <property type="entry name" value="PAXNEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAE1272150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="230" mass="26570" checksum="5CC0EADB3855D5BB" modified="2021-09-29" version="1">MTLVDVSQLIDSSQLQDVHKVKEPKLCAYEKLLQSLHSVGSPLWGDLSTCDVGGSSPEMDIMLPRFIFVFFSLNLKDPGFVRRIERLSDTVVQLESFADSKKARNPLYKDYHGLLNIKQLPKLNSIKCQMPDVMDWAFKLKRKKLVIEKLHLPPDLSVSASRPEDHPATSYRRTLKVKENNLGHFLNAFTKFESLYINSEIDWDSTIGQFNDLLFCFYFYCLFSQSLYFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CPB6</accession>
    <name>A0A812CPB6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_39726</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001867">
        <property type="protein sequence ID" value="CAE1275918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CPB6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1275918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="184" mass="21263" checksum="8122FA11FABDAAF1" modified="2021-09-29" version="1">MFSVMPEQWSVSFRGRLNGSIFCGEKNCFHQSTKRLLHFFLSRPHSLYRLNSSVISLCLLSNQPNVYYTSFCLDHIPLYRLNSSVISLGLLSNQPNVYYTSFCLDHIPLYRLNSSVISLGLLSNQPNVYYTSFCLDHIPLYRLNSSVISLCLLSNQPNVYYTFLSRPHSFISFKLFCDISWSVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CQ99</accession>
    <name>A0A812CQ99_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="14">DNAH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SPHA_38063</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001722">
        <property type="protein sequence ID" value="CAE1273284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5593012at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.130:FF:000005">
        <property type="entry name" value="Dynein axonemal heavy chain 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000044">
        <property type="entry name" value="Dynein heavy chain 5, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001328">
        <property type="entry name" value="Dynein heavy chain 6, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1120:FF:000005">
        <property type="entry name" value="Dynein, axonemal, heavy chain 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2610">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043157">
        <property type="entry name" value="Dynein_AAA1S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041466">
        <property type="entry name" value="Dynein_AAA5_ext"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024317">
        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878">
        <property type="entry name" value="DYNEIN HEAVY CHAIN 6, AXONEMAL-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878:SF71">
        <property type="entry name" value="DYNEIN, AXONEMAL, HEAVY CHAIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12775">
        <property type="entry name" value="AAA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12780">
        <property type="entry name" value="AAA_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17852">
        <property type="entry name" value="Dynein_AAA_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0969">Cilium</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0243">Dynein</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="202"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="810"/>
            <end position="957"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAE1273284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1498" mass="170223" checksum="92D50358F143D35E" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CUH5</accession>
    <name>A0A812CUH5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_40400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001904">
        <property type="protein sequence ID" value="CAE1277071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CUH5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1277071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="190" mass="22186" checksum="DA82C978D7AABF5D" modified="2021-09-29" version="1">MADGKRAANAMLPNGLGEYRGFNATNRFLPFSLVGLSTVGIFLCERKYVRLRPDNFFFCIYYLSDFFSFSTSFFFFLIFCFFPLLSLYTASPILLNFFFLFLLRFSPFLYCRSYASISSFGSTVSRISFFFFLFFFFALFSTLSFIDVINVLFSSFVSNASDFFLYFFFSSSSFLFSLSSRYVVWRSSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CWS8</accession>
    <name>A0A812CWS8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">POGZ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SPHA_42373</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002069">
        <property type="protein sequence ID" value="CAE1280536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CWS8"/>
    <dbReference type="OrthoDB" id="10032537at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050888">
        <property type="entry name" value="ZnF_C2H2-type_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057618">
        <property type="entry name" value="Znf_POGZ/Z280C-D-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24406">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR CTCFL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25429">
        <property type="entry name" value="zf-POGZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="484"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="202"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="833"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1101"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1137"/>
            <end position="1152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAE1280536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1152" mass="131635" checksum="102DBD8E578FCFF4" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CZ82</accession>
    <name>A0A812CZ82_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_42442</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002080">
        <property type="protein sequence ID" value="CAE1280664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CZ82"/>
    <dbReference type="OrthoDB" id="6042561at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1280664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="301" mass="34009" checksum="8FCD1DE6CF37B646" modified="2021-09-29" version="1">MPLSHSPPFLIQQRIPNNGATKSYHGFLYRRPQDLLSQPIYDNNGLIVGLQSAIPNYLKGFDANNRTINIPPAKMMPPFMKGGKTNKGVKLYTLTAYFKHPRLVCNPGARDAKPYKGLYIQMGDDPERDYMEIPLKLKDLSSDWKEAGCVTKMGTHYFKNLSKKLRCEDLYPVFLTYTDGKLGAFGWIFQGNPPKNNKFDLSWYHLSPSLYAFIGLKKKNVPPCMLYPEFQVNGIHIWLRPPSEQLCIKHPIHTSHPSSKTTTTIVQLQIVPGNYYIGNANSPSLAGIFVLLVISIGLHLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CZJ8</accession>
    <name>A0A812CZJ8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_44755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002290">
        <property type="protein sequence ID" value="CAE1284478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CZJ8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1284478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="296" mass="34377" checksum="CF2B07E48730B6B7" modified="2021-09-29" version="1">MFLRIFIFFFSCIGGGPQQSKSFSPEQISPMFLSFFFFFHSSSFLYLLFILSCIYYLGSCPLFFFTSFFLLLSSSSSSSAAFFFFFLLLSFFYLFFLLYYLFFIFLFTCFFFSFFFFLFTSSILLLLLPYFLQFFTLFFLTFHSSSKSSPLPFFPIYFLLFFFFFLFFFFFSSSSLVLLLLPFLFFFFLLLLLLLLPNPILPLPLFHSSSIPSSSSSSSSSSSSSSSSSSSSLPNPFFLFPSSILLPLLETSSSSFLLLLLYLIHSSSSPLPFFFHFLKLLLLLLLLLLLPFFFPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D033</accession>
    <name>A0A812D033_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_46403</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002446">
        <property type="protein sequence ID" value="CAE1287186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D033"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58113">
        <property type="entry name" value="Apolipoprotein A-I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="156"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="249"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="470"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="498"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="639"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="664"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="682"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="770"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="854"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="979"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1019"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1085"/>
            <end position="1132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1287186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1207" mass="130768" checksum="8E395F160A4C1180" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D292</accession>
    <name>A0A812D292_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_45817</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002385">
        <property type="protein sequence ID" value="CAE1286132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D292"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1286132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="196" mass="19944" checksum="F21C72F854417211" modified="2021-09-29" version="1">MSTTSTVPSDIASTSASTAAMSTTSTVPSDIASTSASTPAMSTTSTVPSDIASTSSASTAAMSTTSTVPSDIASTSASTACNVPSIYIYISIHQQSTTVAIASTSASTPAMSATSTVPSDIALTSASTPAMSTTSTVPSDIASTSASTPAMSTSGSFRYSIHISILPSFRYRSFRYSITYQHPLLQCQPLVRFLQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D4C2</accession>
    <name>A0A812D4C2_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Coiled-coil domain-containing protein 18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SPHA_46401</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002446">
        <property type="protein sequence ID" value="CAE1287112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="304163at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18875:SF8">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18875">
        <property type="entry name" value="SARCOMA ANTIGEN NY-SAR-24/CYTOSKELETAL PROTEIN SOJO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1375"/>
            <end position="1409"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="126"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="218"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="397"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="536"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="790"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="902"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1375"/>
            <end position="1384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAE1287112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1504" mass="174638" checksum="06F3036CA7D1127D" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D784</accession>
    <name>A0A812D784_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_47866</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002635">
        <property type="protein sequence ID" value="CAE1289856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D784"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1289856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="218" mass="23436" checksum="51C32C2463B9E783" modified="2021-09-29" version="1">MNSHSPSLSPFFPSISCLSSPLLSFPLLLAPSLPFFFFFPLYPLSLSTLSSSPSTCPTLSSQSLSPVSPLLHLLTFSLLAFSSSSSLSPSPFSLSLSLFLYLSPHSLPNLSPLLHLFNFSLLAFSSSLSRSPSLRLSLSLSFSLPLSRFCLPLLLSHLSPFLSPPLSLSLLSLSLSLSRCLSPSLPHFPCFPVLDGYGPSSHASNLHIISYSPLLHIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D890</accession>
    <name>A0A812D890_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_49298</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002808">
        <property type="protein sequence ID" value="CAE1292496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D890"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1292496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="179" mass="20313" checksum="EA0678DC252858AA" modified="2021-09-29" version="1">MLHGHTNFTSFSSLFPSSYIPPDCSLKNCLCKAILSYYMANNFTSFSSLFPSSYIPPDCSLNSPSYIPPDCSLKNCLCKAILSCYMAIPTSLPFLLYSLLLHSTRLFFEELSFARLSYHVTWPYQLHFLFFFIPSSYIPPDCSLKNCLCKAILSCYMAIPTSLPFLLYSPPPTFHQIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D8T0</accession>
    <name>A0A812D8T0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_49581</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002855">
        <property type="protein sequence ID" value="CAE1293001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D8T0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1293001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="158" mass="18275" checksum="FDA0162DC5CD28D9" modified="2021-09-29" version="1">MHPSQSIYLLGWSKTTLLRHYFCTNLISIYLSIYLSIYLSIYLSIYLSIYLSLLLCIDLSTQSASMYVCNQSIYLSTQSASIYLSIYLSIYLSYNPNEQAQTEHNFFHVDRSIYLSIYLSIYLSIYLSISVCFYQSAFICLNIYLSIDLAYNPYGGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D916</accession>
    <name>A0A812D916_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TBX2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_49136</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002781">
        <property type="protein sequence ID" value="CAE1292177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D916"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="450"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="481"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="532"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1292177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="574" mass="62603" checksum="16E800176B0EEF3C" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DBR4</accession>
    <name>A0A812DBR4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Puratrophin-1,Pleckstrin homology domain-containing family G member 4B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SPHA_49816</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002889">
        <property type="protein sequence ID" value="CAE1293474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DBR4"/>
    <dbReference type="OrthoDB" id="6152532at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13242">
        <property type="entry name" value="PH_puratrophin-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052231">
        <property type="entry name" value="Rho_GEF_signaling-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055251">
        <property type="entry name" value="SOS1_NGEF_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45845:SF3">
        <property type="entry name" value="PURATROPHIN-1-LIKE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45845">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22697">
        <property type="entry name" value="SOS1_NGEF_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="3">
        <location>
            <begin position="344"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="532"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="706"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="805"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="258"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="709"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="813"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="836"/>
            <end position="851"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAE1293474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="893" mass="100544" checksum="3B28EE1EA7AFC939" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DFU5</accession>
    <name>A0A812DFU5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_55345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003676">
        <property type="protein sequence ID" value="CAE1303025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DFU5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1303025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="197" mass="22447" checksum="FEAB8A8978A200EA" modified="2021-09-29" version="1">MRFASKQAARNHVTVKLSKRLTKISLPETLCDSSPPPPLPTKAPVISCLCLTFGKNLTYEILRLSNSIYLSIYLSIYLSIYLSIYLGLFIIYLYSFCLIYLSIHLILLSSICISNNRSINLPIVESYLSIYLSIYLSIYLAKNFHICHSPFLSLPLSISVHLYYCSSKLFGKDREHKQAANEVLTILNVWRSLVIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DFW9</accession>
    <name>A0A812DFW9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">KRAB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SPHA_52175</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003216">
        <property type="protein sequence ID" value="CAE1297629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DFW9"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000264">
        <property type="entry name" value="Zinc finger protein 236"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050527">
        <property type="entry name" value="Snail/Krueppel_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388:SF54">
        <property type="entry name" value="PROTEIN ESCARGOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="2"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="58"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="125"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="473"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="479"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAE1297629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="770" mass="85467" checksum="E10E752D98BA6800" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DHG9</accession>
    <name>A0A812DHG9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_51861</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003174">
        <property type="protein sequence ID" value="CAE1297164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DHG9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1297164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="167" mass="19534" checksum="7E8ECDB4B4AA8BFA" modified="2021-09-29" version="1">MTAAAATLFNYQMPVIKDEYLCRKILRADHSPSFLYSSQFLNLFSLSFFLLFSVFLSSLFFHFLNFLSHFIFYISSSSLLLFEVFSYFLLSLPFMSITLTSFSFTFLLLLLLNTILFKSFPFSFPTFIPSLHIILFIPFFHSFLKLFQVYSVFAHLDSLLLFASIQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DHV8</accession>
    <name>A0A812DHV8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_53276</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003380">
        <property type="protein sequence ID" value="CAE1299537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DHV8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1299537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="185" mass="21279" checksum="3172534E2D4EC4EE" modified="2021-09-29" version="1">MVARELAAVAITFLAKHTPKRKKKPDSIIPVFFFLFLFSFSPLSSLFLNMHRLFSFSTLILFIVLLLLVLPFSVHLFTLFIFTHLPLFRMFLLLSFCISFSHSHTHTHTHTVLLLHPQQFYLSIYLSIYLSIYLSIYLIFITACCLIVVDLSVGGDYLPLKSIYQSLSLSLSLSLSLSIYLSIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DHZ3</accession>
    <name>A0A812DHZ3_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Phosphodiesterase</fullName>
            <ecNumber evidence="10">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SPHA_52606</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Farmed</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3',5'-cyclic GMP + H2O = GMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16957"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57746"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="EC" id="3.1.4.35"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="10">Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Purine metabolism; 3',5'-cyclic GMP degradation; GMP from 3',5'-cyclic GMP: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cyclic nucleotide phosphodiesterase family. PDE9 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="10"/>
    <dbReference type="EMBL" id="CAHIKZ030003299">
        <property type="protein sequence ID" value="CAE1298513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DHZ3"/>
    <dbReference type="OrthoDB" id="546632at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047555">
        <property type="term" value="F:3',5'-cyclic-GMP phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1300.10:FF:000006">
        <property type="entry name" value="Phosphodiesterase 9A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023088">
        <property type="entry name" value="PDEase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023174">
        <property type="entry name" value="PDEase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11347">
        <property type="entry name" value="CYCLIC NUCLEOTIDE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00387">
        <property type="entry name" value="PDIESTERASE1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00126">
        <property type="entry name" value="PDEASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0140">cGMP</keyword>
    <keyword evidence="4 10 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDEase" evidence="11">
        <location>
            <begin position="136"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="223"/>
            <end position="227"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="371"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="371"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="422"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00061167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAE1298513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="480" mass="56677" checksum="FEA9148135892091" modified="2021-09-29" version="1">MYYYIAGETFRSIAEAGPNDILKLHNQKGFFLQISSNIPVNTPDDRYQLEVVAKVWRDRIPDEVLEQWENIERRLATLENLVIYQTTMPKCFEELLTKVNNVKNKVEGIAYLSWLGLYKDLPNSKTIVPLWDKYKMKDEKLKQQQYVIDKYRRISESQFSLNIRNYLKQSSFDNWQWEEAEMLLLLETMFQELNFISTFNIQFSTLQEWLCDIYLHYFNVPFHNFKHCFMVTQMMYSLIWQLELRNILSEEDLLTLLISAICHDLEHSGFSNVYHVNAQTMLARTYNDRSPLENHHCDVAFRILEKWGLLKSLSKEQYLEVRQGIIRCILSTDMAKHLNILQDFEAVLNDFNPEKKEHRLQLMSILIKVADISNELRPLEVAEPWLECLLNEFFAQSDAEKLEGLPVTAFMDRETVVRSKSQVHFIKNVLLPLLQALARCFPKAVSLLISPAHEALSYYERQSQEYENDQRNKEAAQKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DIW2</accession>
    <name>A0A812DIW2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_54491</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003537">
        <property type="protein sequence ID" value="CAE1301528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DIW2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1301528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="168" mass="19622" checksum="B54BDFE42E4C92C6" modified="2021-09-29" version="1">MSSIFSHIYVFLSDRIYLSIYLSIYLSIYLSIYLSISVYAYLSIYLSIYLSIYLSIYLSIYAPGLNNEVLIPKNSPYLLNDPRIYLSIYLSIYLSIYLSQSIHILSIYLSIYLSIYLSIYQKLLILIDVLSYQHFLASITLDSHGQTHIYLSIYLSIYLSIYLSTRVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DJA8</accession>
    <name>A0A812DJA8_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_54693</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003576">
        <property type="protein sequence ID" value="CAE1301922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DJA8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032430844" description="NADH dehydrogenase subunit 6" evidence="2">
        <location>
            <begin position="18"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1301922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="160" mass="18268" checksum="9FE2B9F1D9DE2B7A" modified="2021-09-29" version="1">MIMIIFLFSFIVVFSSSSSSSITCSPLLSTAPPQPSSSSSSSFFSVLTRLPAAIYYIFNNRKSFIDDRLDNYKKTTTYFTISIYLSIYLSICLLSIYLSIYLSIYLSLFITVYLSQFAHIYLSQFIYNCLSIPVCSYLSIYLSIYLSIYLSIITIIDQIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DJT3</accession>
    <name>A0A812DJT3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_57317</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003863">
        <property type="protein sequence ID" value="CAE1304775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DJT3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1304775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="204" mass="21831" checksum="3CA2F06D9DC4C145" modified="2021-09-29" version="1">MEISLALSFFGGNCKAFSLSLSLSLSLARARAILLCWKLQSCLSLSHPLSLSLSLYLSFSLSLPLSSCVGNCKAFSLSLSPSFSLSPSFFLFLSLSVCLSPPILLSLTYRLIFNFSFFPFLFSSPLSLSLSLPPLFPSLPSLPPSFSLSPLPLSPLSPLSLPPSPSLPSLSLPSPLSPLFIPSPLFLPSPLLSLFTFSLSFCLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DNL1</accession>
    <name>A0A812DNL1_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SPHA_59549</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Farmed</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="7"/>
    <dbReference type="EMBL" id="CAHIKZ030004123">
        <property type="protein sequence ID" value="CAE1307523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DNL1"/>
    <dbReference type="OrthoDB" id="331948at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF488">
        <property type="entry name" value="PALMITOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="28"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="290"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="9">
        <location>
            <begin position="180"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAE1307523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="388" mass="44460" checksum="B37FE5E9B6791859" modified="2021-09-29" version="1">MKSSNYSSPAPDLGPVHLNFFSYYGRMLFAMEFLTLLIGYLLVFSFFTVVCICGDHPSCINGPIGWVKRSLTKAFFCLIPKQIVDLGTRFVYYVYQQRNPTMQIVFGILVLSGHAIVVIDIFPILYGIFHDDNHVLVPMLLLFLNLFVFYKLCGADPGEITKDNHGVYSFIYPYDGAIYQKKTICKTCNFSKPARSKHCSVCNRCVHRFDHHCVWTNNCIGALNNHYFLAFLITLIMMCVNGFYMALRSIVSIAQYSGMVDALIMQANGKMTPVTLSALVQHLFMQFPRIIFLMASLSVLSLLMAGFTVYHLYLMFTNQTSNERYKIGSIKNSERCCRKENTEATQSKKPNKRKTLNTRPYNQGFLKNIAQVLFPKNYIEKHKKVSHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DQN0</accession>
    <name>A0A812DQN0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_58937</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004076">
        <property type="protein sequence ID" value="CAE1306773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DQN0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1306773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="186" mass="22919" checksum="4E49B58C6F155439" modified="2021-09-29" version="1">MACPALINTLTHKSIYLSIYLSIYLSIYLSIYLSIYRGLLTVCLVDKNERKTRTQKLSFFFFFLLFLLLFLLFLLLFLLFLLFSFFPFSFSPFFFFFFFFLFFFSSTFSSSFSSFFFFSSSFSSFSYFSSFLFFLFFFFFSFFLLLFLLPFLLFSSFSSFFFFFSSFFFSSFFFFFFFFFFFFFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DR34</accession>
    <name>A0A812DR34_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_61114</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004296">
        <property type="protein sequence ID" value="CAE1309396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DR34"/>
    <dbReference type="OrthoDB" id="6161790at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1309396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="321" mass="36569" checksum="F405E22C3D3C1BFA" modified="2021-09-29" version="1">MTSKRRHELWMIFNAFLYIKSSAIYLSIYLSIYLPHLSISIYLISHLSIYLSISVCSHLSIYLSMYLSIYLSVLTSIYLSQCAHIYPSIYLSIYPSVLTHLSIYLSQCAHIHLSIYPVCSHIYLSIYLSVLIIYLSIYLSVLTSIYLSISVCSSSISSIYLSIIYLSVLTSIYLSIYLSHIYLVSITSIYLSHLSIYLSVLTSIYLSIYLSVLTSIYLSISVCSHLSIYLSQCAHIYLSIYLSVLTSIYLSIYLSIYLSVLTSIYLSIYLSIYLSVLTSIYLSIYLIYLSHLSIYLSIYLSVLTSIYLSIYLSILLLPGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DR49</accession>
    <name>A0A812DR49_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_60643</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004226">
        <property type="protein sequence ID" value="CAE1308821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DR49"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1308821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="216" mass="24811" checksum="34E514E726D7FC9D" modified="2021-09-29" version="1">MFFCQIMLGLINSTYSFPFLSLSLSLSLSRTRAHTHTPQNQILSFPISLTFALSLTSFSVTPLSFSHFLIGTLLSRMIFSLYLSVRHFNLSLSFLFPAPLSLSLSLSLSLFLLSAFQFFFLSFDIFLSFSFILPLFLSFHSQLLAPLFPPSLSCLFPTYLCFLSFYVPQFFFLLFLSLFLTFLLSFSTFVPIYFSLSHPFSLSRFQIIIHPLFLFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DUH0</accession>
    <name>A0A812DUH0_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome b-c1 complex subunit Rieske, mitochondrial</fullName>
            <ecNumber evidence="11">7.1.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SPHA_60560</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Farmed</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:11484"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="7.1.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
        <text evidence="11">Binds 1 [2Fe-2S] cluster per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="11">The Rieske protein is a high potential 2Fe-2S protein.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Rieske iron-sulfur protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.8" evidence="11"/>
    <dbReference type="EMBL" id="CAHIKZ030004214">
        <property type="protein sequence ID" value="CAE1308724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DUH0"/>
    <dbReference type="OrthoDB" id="1637982at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008121">
        <property type="term" value="F:quinol-cytochrome-c reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03470">
        <property type="entry name" value="Rieske_cytochrome_bc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.270:FF:000001">
        <property type="entry name" value="Cytochrome b-c1 complex subunit Rieske, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.102.10.10:FF:000001">
        <property type="entry name" value="Cytochrome b-c1 complex subunit Rieske, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.270">
        <property type="entry name" value="Ubiquinol cytochrome reductase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037008">
        <property type="entry name" value="bc1_Rieske_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014349">
        <property type="entry name" value="Rieske_Fe-S_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005805">
        <property type="entry name" value="Rieske_Fe-S_prot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004192">
        <property type="entry name" value="Rieske_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006317">
        <property type="entry name" value="Ubiquinol_cyt_c_Rdtase_Fe-S-su"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01416">
        <property type="entry name" value="Rieske_proteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10134">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02921">
        <property type="entry name" value="UCR_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00162">
        <property type="entry name" value="RIESKE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81502">
        <property type="entry name" value="ISP transmembrane anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Rieske" evidence="13">
        <location>
            <begin position="198"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAE1308724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="268" mass="29377" checksum="915FC093741966C5" modified="2021-09-29" version="1">MINLLPKLSGTFTKQVVSHVSRPIISDLPVLSSAIAIHPPIKDTSPSNLCRQIPNNGVTASYGLTSQSQVRFAHTDIQIPDFSAYRRECVMDSTKPNKDSDESRKAFTYLLSIGGSVTAVYAAKSIVHEFVSSMSASADVLALAKIEVKLGDIPEGKNVTFKWRGKPLFVRHRTVDEIETEQAVDISCLRDPQHDNDRCQKPEWLVLLGVCTHLGCVPVANIGDFGGYYCPCHGSHYDAAGRIRKGPAPLNLEVPPYIFKDEETIVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DUV3</accession>
    <name>A0A812DUV3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_62989</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004513">
        <property type="protein sequence ID" value="CAE1311582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DUV3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1311582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="320" mass="38034" checksum="0748D300F2C72F91" modified="2021-09-29" version="1">MIKVFLSIEKPSLSIPSFLDFTLPAASFFSLHIYLSIYLSIYLSIYLSIYLFESVHIYLSIYLSIYLSHLFSYLSGSVHIYLSIYLSIYLSIYLSIYLSSCSSLSRCIHIYLSESVHIYLSIYLSIYLSLFISIYLSIYLSIYLSISLIFISLRFGSYLSVYLSSCSSLSRCIHIYLSIYLSIYLSIYLSIYNRVHHLTIVGRSRAGMRTCEHVLMIKFHFLYISSFVSLSSAYCFSFLLFFFCFDDFVSFCEPIRFLFFFFRYPCFFYFLSNYLFFFYLRLRYLFIFICNIILKDLTLLTSYFFYTYNSPLFFFLPAIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DVK0</accession>
    <name>A0A812DVK0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_61123</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004296">
        <property type="protein sequence ID" value="CAE1309410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DVK0"/>
    <dbReference type="OrthoDB" id="7488960at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1309410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="160" mass="18610" checksum="DABACF397C72B521" modified="2021-09-29" version="1">MWGSLMIDQIRGSLKLEQIRGSLKFDRIQASLRLEQIRGSLKLEQIRGSLKLEQIRASLRLEQIRGSLKLEQIRGSLKLDQIRASLMLEQIRGSLKLEQIRGSLKLEQIRASLRLEQIRVSLKLAQIRAPLRLEQIRGSLKLEQIWGHLRNQEQFPTVKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E138</accession>
    <name>A0A812E138_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_62440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004467">
        <property type="protein sequence ID" value="CAE1310951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E138"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="307"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="345"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="377"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="414"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="441"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="489"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="514"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="542"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="603"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="639"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="676"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="702"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="731"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="813"/>
            <end position="833"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1310951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="835" mass="100227" checksum="8085F9C86DEE1263" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E490</accession>
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        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="5" type="ORF">SPHA_66311</name>
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        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
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            <taxon>Coleoidea</taxon>
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            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Farmed</strain>
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    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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        <property type="entry name" value="Cyt_c_oxidase-like_su3"/>
    </dbReference>
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        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
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        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
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            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
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            <begin position="28"/>
            <end position="969"/>
        </location>
    </feature>
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        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="122"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="164"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="209"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="235"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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        <location>
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            <end position="583"/>
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    </feature>
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            <begin position="431"/>
            <end position="717"/>
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        <source>
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        <source>
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        <source>
            <dbReference type="PROSITE" id="PS50855"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAE1315380.1"/>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
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            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
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                <person name="Li R."/>
                <person name="Bekaert M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="CAE1316192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <location>
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        <source>
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        <source>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="entry name" value="Ig_sub"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DPR-INTERACTING PROTEIN ETA, ISOFORM B-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="Ig_3"/>
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        <source>
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        <source>
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    </evidence>
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        <source>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAE1316116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="175" mass="19737" checksum="336B9A6B192CDD46" modified="2021-09-29" version="1">MSNFLSFLVIWIFFPKFNLCHSEFERANGLPLLTINSRFKVLDTGLKIINISHGDEGNYTCTAVNDAGNQSVSGVLTVESGPHFVSFPQNTVTQMGHSVIFVCDAVGDPKPRITWTFNDSFSLPLSVNKSRDGHRLYIDSMSWKEVGKYTCFAENLRSIKNKTAYLFLQGKQRMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E6X4</accession>
    <name>A0A812E6X4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_67758</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004908">
        <property type="protein sequence ID" value="CAE1317150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E6X4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="284"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="366"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1317150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="394" mass="45975" checksum="D788AD191BD887C5" modified="2021-09-29" version="1">MFPTCKFVYTLNASDICFAKRNGFLPAMNADKQTFRPLTSARFLATENNVCDESRLRSTKFVFLFSFFISSSSSSSSSSSASSSSSSSSFIFFFYFPSSSSSSSSASSSSSSSSSSCTPSACLLLHFSFSTTLFFFFFFFFFFFFFFFIFFFFDLLLISPYASFSFFLSFFLSFFLSFVLFSFFLSFFLSRSSTNFPLRFIFFLSFFLSFFLSFFLSFFLSSTPFTQSSFFFFFLNVFLFGLLISFFYCLFSFFLSILLRLFFFFFIFLRFSFSRVFSFHNLHFLSLLFSLFLYLNFILLLFIISPFFFPLLTIFSLVTKLLYSFYFMILFPTQLKAIVNSCFHSFFSSLFPPLFSPLFPPLISPLFPPLFSPLFPPIFPPLFPLLWNSTVCLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EBZ4</accession>
    <name>A0A812EBZ4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_68453</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004980">
        <property type="protein sequence ID" value="CAE1317930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EBZ4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1317930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="265" mass="30781" checksum="F021E4DB22ABA455" modified="2021-09-29" version="1">MVVSALAEFGDGRPLLTGNLTNIKCLSIYLSIYLSIYLSIYLSISMPIFVYINLYSSFSMSISIYLSIYLSIYLSIYLSQSCVHIYLSIYLSIYLSIYLSIYPSIYLSISMSIFVYINLYRSFIMSISIYLSIYLSIYLSIYLSIYLSISILCPYLSIYLSIYLSIYLSIYLSIYLNLLIFIYQYQCVHIYLSIYLSIYLSIYLSIKICSHPPIYLSLSTFSYLSIYLNLVSKSVHKDLSKSVAIYLSIYLFQSIYIYPSIYLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ED80</accession>
    <name>A0A812ED80_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_71471</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005236">
        <property type="protein sequence ID" value="CAE1321386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ED80"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="337"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="400"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="441"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="481"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1321386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="551" mass="62910" checksum="A149C08354508153" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EEH0</accession>
    <name>A0A812EEH0_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_70813</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005183">
        <property type="protein sequence ID" value="CAE1320581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EEH0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1320581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="185" mass="21083" checksum="04D709CDE913315F" modified="2021-09-29" version="1">MYPIVKASQIKNQQSLYETASLTLYLSLSHSLCETFSSSLFLFLRRERLSFPLSFSLSIFLSLSSKTRSLLKLSILKLIISLSISLYIYLFSEALPSLLLKHSLPLSFSSFLCLSLFLYLLKFSLSFKLYFSFSLETISLFFPSLSLSLSLSLSIYILRLSFSLKRRENEENEDEGGGNNNNSNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EG10</accession>
    <name>A0A812EG10_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_74657</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005435">
        <property type="protein sequence ID" value="CAE1324929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EG10"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="299"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="390"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="415"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1324929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="454" mass="54524" checksum="54EF7673C74EE04C" modified="2021-09-29" version="1">MIIQNHSSFFNDLHLTLLFFFVTADIVLSTLLFCSSHHYYRYYFLFIFGFCFYLIHFLFNFFSLSLSFSLKVVSFFFGSLTLFFFFHFLFCRSLFYLLLSTRYLARSRPFSTFYITYLFAVIFKPIFTFSIYTFLTPIQYSLSLSLSFSLSFLLSLFPSLSFLSPSLSLSISLSHSLSLSHIYVFHSFPFIFLNFYSLTAFFLSLKGFNSCLFFTSFYCLFFSILNLFLLLSFIFLICHSLAVVFLSLRGFHIIFTSFYRLFLFIRLFLFIVFFFLSLLSFIWAMFLSLAIFILLHTDFYFFFTLFSRLFLMINLSLFFHFLICNFSSYVLPFSYYYIFAYSHLTFSIYFIYSRILFIHFSFFTVSFFTSFTSIIPTIHCNTLTSFFNCIIYTFFAFFSFCYPFILFLLSFFLSFFLYFFLIFFLFLFILRLLSIHPFTFPLSLLCRLSFLSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EH25</accession>
    <name>A0A812EH25_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_73509</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005380">
        <property type="protein sequence ID" value="CAE1323651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EH25"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1323651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="220" mass="24400" checksum="D0061D89A90DDC09" modified="2021-09-29" version="1">MQNHSTLPLFKYIVTPCSSSSKSKAFFNGRKSRGTVVSRSVLAASPYPVCLNDMPPTTVSDWQIPLSPSLFRLPETIPLSLPSANTPSEIYTDTSTLWWVETTPSLLSPTSLDSRDRHWLLRRPISFGIAIELSLEPLRCHICFVIAIELSLQHITCHISFDIAVELSLRPLRCHISVGIAIKLSLPPITCHISFDIAVELSVRTLRCHISVGIAIELSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EJK3</accession>
    <name>A0A812EJK3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_74290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005415">
        <property type="protein sequence ID" value="CAE1324561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EJK3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1324561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="201" mass="23619" checksum="807F025D279600C9" modified="2021-09-29" version="1">MASTTTKVHLRKEFMSQTEKYDCPYELVVNICRYLPQILASWKQIFWKKDYPTYKLQDGQIALKRRVPFRSVHGRWDRLETLNTLNANQQQKPFLPRFLFSSFIALFFFFSFSHHFILSIFISIFLLLASISLPLLSSSSFFLSFFLPHTFLSIKFLTDLIKGLLVLFSLSLSFSLLSIYLSIYLSIYLSIYLSIYLSIPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ELK5</accession>
    <name>A0A812ELK5_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SPHA_74678</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005436">
        <property type="protein sequence ID" value="CAE1325002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ELK5"/>
    <dbReference type="OrthoDB" id="6076970at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228">
        <property type="entry name" value="B2 BRADYKININ RECEPTOR/ANGIOTENSIN II RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228:SF59">
        <property type="entry name" value="NEUROPEPTIDE RECEPTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="184"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="285"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="1"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAE1325002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="375" mass="43070" checksum="2E2B116908EF995C" modified="2021-09-29" version="1">MVAIAFDRYFCICHSLKNIMNRRRAKVIIIILVFFAAGLGTITCLTHGVYRLKLSNETVLTNLSRPTRVGNDSRLSDLTSRISVDCQADNLTDTMFSAPCKEFSEYYNTAVTLKKDGLQDISDAIQRQRQYDDQILSTDDLQLYMNFSQFVERTVTSYSIEYIGKCNPSEVLLSRRFRYIYQKIYAFLFLVDFCVVFVLYVLIYRFLVTRRIKRQRSRSLRSISTAHPASTDNSTLETRFLTEMPCPSPSPVVVAAAAAVAAASSSSGSMRRAAMRHKVPPKERLLMANIRTAAMLFVVTVVFIVVFLPAWLTAMGFLPTNKIVFYSYFLYNVVNPFIYAFMNPMFKKELQKMLSLRKRVIRPRCFWDSDVQASY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EM25</accession>
    <name>A0A812EM25_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_78517</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005542">
        <property type="protein sequence ID" value="CAE1328911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EM25"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1328911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="205" mass="24289" checksum="CDB1B2B853763340" modified="2021-09-29" version="1">MTFFFSSFFVKSISFGYIFPFIDIILLFSPFSFFFVLFFRLFLVFLLRLRHRLPLLHRRRLPLLRRCCHRFLLLLLFLFLSFFLSFFLSVFLSVFHFLSFCLPFSLPFRFFFYISFCLSFCLSSSFSFCLSTLLSSCLLFYVSFCLSLCLSFCFYFVFHSDISSFFPPIFSSVFLSASLSVFHSGFPPLFVTFSFLPLSSFSNTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EUI8</accession>
    <name>A0A812EUI8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_81144</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005625">
        <property type="protein sequence ID" value="CAE1332059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EUI8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="378"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="402"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1332059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="420" mass="48598" checksum="6166D40415E0A11B" modified="2021-09-29" version="1">MRITLKTALFLTSSISRVFLDIFPFLLPPTFFSSHSLFSFISHYYFLAFSPLFVKYNIFVVFYKHTHTLVSIYLSIYLSILVGSLSIYPSLFIIYLSIYLSIYRSLFIIYLSIYLSIYLSIYLSIPVCSLSIYLSIAVCSLSIYLSIAVCSLSIYLSIYLSIYLSIYPSLFIIYLSIYLSILVCPLSIYLSLCIIYLSIYLNVCIYYNIIPPMNCNKQRSSTPVYSANLDLLLTLLSSTFHSSLTFVSDHLQIFFLFFSASNIAIWAKKNPSDFGTWKKRYLPSWWRQGRIEPTSHDKLLEVSLSLSPTSLLTSTNLSPPVALPYLLCRQPICRIQYRQARVGRLIPVTKTPAIFAYAFVFFLIFFCTKKKTNKQKEVYLSIYLSIYLSIYLSIYLSISPSLSLSLSIYIYIYIYIYIYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EW05</accession>
    <name>A0A812EW05_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">INO80E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_81304</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005630">
        <property type="protein sequence ID" value="CAE1332226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EW05"/>
    <dbReference type="OrthoDB" id="5977486at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026678">
        <property type="entry name" value="INO80E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056515">
        <property type="entry name" value="INO80E_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21812">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21812:SF1">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24237">
        <property type="entry name" value="INO80E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="INO80 complex subunit E N-terminal" evidence="2">
        <location>
            <begin position="23"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1332226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="257" mass="28393" checksum="7282B6853C6F4D84" modified="2021-09-29" version="1">MPVSASGGGPVTNTENAIDYQVDYKRKYKNLKSKLKFLVYEQECFLEELRKAQRKLLKVSRDKSFLLDRLLPYEKINDSSGDSDATASSESDIESNQEGSSLKKKKSASSVSPGTVPVVTPPVTSSSLLRTDTSNIFCNNYTSLLPQSTSLSQIVTPETKKKQKTTTKRSATKTIVTAKPPEPEPERIAGQMTREELERHLESRQHSFGIEKAPAKLPMEIFSNENSDPDSESAQDMSGLIGDVDDDDAELVIDTPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ALJ2</accession>
    <name>A0A812ALJ2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_759</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000020">
        <property type="protein sequence ID" value="CAE1141069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ALJ2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1141069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="170" mass="19608" checksum="76C71085D8AFBCFD" modified="2021-09-29" version="1">MQKKLETQTQKDNIFLSFFLSLSLSLSLSLSLSNTMTYMFISIIVFLCTTHSEKRGSFSTSYPEAFHPLYPELSLYSYNLSVYLSASLPYHSLLIFTAQLLLFIISSSLASTFFLYVSPLFSVVRLSLFLYFYVFSRLLFSFSFSFFFVSPLFDYFYLSLSLSLSLSLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ALN7</accession>
    <name>A0A812ALN7_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">26S proteasome non-ATPase regulatory subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SPHA_1129</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Farmed</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the proteasome subunit S1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000030">
        <property type="protein sequence ID" value="CAE1142797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ALN7"/>
    <dbReference type="OrthoDB" id="261572at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042176">
        <property type="term" value="P:regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000017">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016642">
        <property type="entry name" value="26S_Psome_Rpn2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002015">
        <property type="entry name" value="Proteasome/cyclosome_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048570">
        <property type="entry name" value="PSMD1_RPN2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040623">
        <property type="entry name" value="RPN2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943:SF2">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13646">
        <property type="entry name" value="HEAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01851">
        <property type="entry name" value="PC_rep"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18004">
        <property type="entry name" value="RPN2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21505">
        <property type="entry name" value="RPN2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015947">
        <property type="entry name" value="26S_Psome_Rpn2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="26S proteasome non-ATPase regulatory subunit 1/RPN2 N-terminal" evidence="8">
        <location>
            <begin position="2"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="26S proteasome regulatory subunit RPN2 C-terminal" evidence="7">
        <location>
            <begin position="692"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="156"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="742"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="856"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="748"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="877"/>
            <end position="892"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR015947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF18004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF21505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAE1142797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="892" mass="98743" checksum="8BC832FF26F20900" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AM56</accession>
    <name>A0A812AM56_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CASC1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_1566</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000044">
        <property type="protein sequence ID" value="CAE1145105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AM56"/>
    <dbReference type="OrthoDB" id="297923at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048487">
        <property type="term" value="F:beta-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022110">
        <property type="entry name" value="CASC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023247">
        <property type="entry name" value="IC97/Dnai7-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20929:SF11">
        <property type="entry name" value="DYNEIN AXONEMAL INTERMEDIATE CHAIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20929">
        <property type="entry name" value="LUNG ADENOMA SUSCEPTIBILITY 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12366">
        <property type="entry name" value="Casc1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CASC1 C-terminal" evidence="1">
        <location>
            <begin position="7"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1145105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="160" mass="18455" checksum="2157582210BB83D0" modified="2021-09-29" version="1">MKPEQLIKELQWCGVNVFPSKDASKYVSIQIKSSVLEDHVYQQISLVASAMGFSWSRWNGEAERDDIILQATECLVDEPLQENLLTYQVNKTHVTRIKLSEFDEDFSLEPVDSTAYFSNFYHLMKKTGSEEARLRIENTNAEFRDCVKKMLSATKVLTYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812APE8</accession>
    <name>A0A812APE8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_2052</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000058">
        <property type="protein sequence ID" value="CAE1147157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812APE8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="102"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1147157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="166" mass="18870" checksum="04308363B9A5C97B" modified="2021-09-29" version="1">MIFYNYYFFFFFFFFFFFFFFSPFSSLLFLLLFLFLPLLLDIILLFLFLLLLLYLLVLLFRLVFFLLLLLFALLLLIISPPLLFSSSTSCHPPPIPLPRPSSPSSCSLSSRPSSSSSSSSSSSSSSSSSSSYPRSTYTFPPPPPQFPSSSSISFPFTYAQTLFVNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AR79</accession>
    <name>A0A812AR79_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Spindle assembly abnormal protein 6 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SPHA_4028</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000123">
        <property type="protein sequence ID" value="CAE1153729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AR79"/>
    <dbReference type="OrthoDB" id="49058at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007099">
        <property type="term" value="P:centriole replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10142">
        <property type="entry name" value="HD_SAS6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.210.20">
        <property type="entry name" value="Spindle assembly abnormal protein 6, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032396">
        <property type="entry name" value="SAS-6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038558">
        <property type="entry name" value="SAS-6_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041513">
        <property type="entry name" value="SAS6_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44281">
        <property type="entry name" value="SPINDLE ASSEMBLY ABNORMAL PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44281:SF2">
        <property type="entry name" value="SPINDLE ASSEMBLY ABNORMAL PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16531">
        <property type="entry name" value="SAS-6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18594">
        <property type="entry name" value="Sas6_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90257">
        <property type="entry name" value="Myosin rod fragments"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spindle assembly abnormal protein 6 N-terminal" evidence="9">
        <location>
            <begin position="5"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="SAS-6 coiled-coil" evidence="10">
        <location>
            <begin position="147"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="596"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="670"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="158"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="252"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="413"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="608"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF18594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAE1153729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="696" mass="79369" checksum="6A2B37676B378EF5" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ASX1</accession>
    <name>A0A812ASX1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_4086</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000126">
        <property type="protein sequence ID" value="CAE1153958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ASX1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1153958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="310" mass="35671" checksum="8B3CE5FA3A2D5501" modified="2021-09-29" version="1">MSLPGKRSVSVDYESPREETGKRKRPASVDYESPREETGKRRLRVSQGRDRKRDYESPREETASETTSLPGRDRQARLRVSQGRDRKRDYESPREETASETTSLPGRDRKPRLRVSQGRDRKRDYESPGKRPQARLRVSQGRDRKRDYESPREETASETTSLPGKRPQARLRVSQGRDRKRDYEVSQEETASETTSLPGKRPASVDYESPREETASRDYESPRKRPQARLRVSQEETASETTSLPGKRPQARLRVSQEETASETTSLPGKRPASVDYESPREETASETTKSPRKRPQARLRVSQGRDRQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AUS5</accession>
    <name>A0A812AUS5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_5893</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000193">
        <property type="protein sequence ID" value="CAE1159263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AUS5"/>
    <dbReference type="OrthoDB" id="9635126at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134:SF22">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134">
        <property type="entry name" value="OS08G0543275 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="347"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="371"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="409"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="436"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="464"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="488"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="520"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1159263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="563" mass="66078" checksum="27B6392BE20441AA" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AVM2</accession>
    <name>A0A812AVM2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNAH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SPHA_5466</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Farmed</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the dynein heavy chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000181">
        <property type="protein sequence ID" value="CAE1158032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AVM2"/>
    <dbReference type="OrthoDB" id="6120175at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005858">
        <property type="term" value="C:axonemal dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.100">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042222">
        <property type="entry name" value="Dynein_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532:SF4">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532">
        <property type="entry name" value="MALE FERTILITY FACTOR KL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08393">
        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="224"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="255"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="437"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="476"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="507"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="534"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="569"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="607"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="631"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="664"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="690"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="718"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain linker" evidence="3">
        <location>
            <begin position="49"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain linker" evidence="3">
        <location>
            <begin position="309"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAE1158032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="757" mass="90770" checksum="71DACFEEE817A791" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AWD7</accession>
    <name>A0A812AWD7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_7036</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000225">
        <property type="protein sequence ID" value="CAE1161853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AWD7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1161853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="320" mass="38538" checksum="03E64791F78E0150" modified="2021-09-29" version="1">MFIGIPLVPYLSIYLSIYLSIYLSIYLSIYLSQTVSIYLSIYLSIYLSIYLSIYHHHRLFLSIYLSIYLSIYLSITDCFYLSIYLSIYLSIYLSITDCFYLSIYLSIYLSIYLSLFIPILLSLFFIHIYLSIYLSLSLFISIYLSIYLSIYFHTYFTIFIHIYLSINLSIYLFSYLFYYLYSYLSIYQSIYLSIFIPILLSLFISIYLSIYLSIYFHTYFSIFHISLASYESYLYSYLSIYQSIYLSIFIPILLSLFISIYLSIYLSIYLFSYLFYYLYSYLSIYQSIYLSIFIPILFSFLASYESYLYSFIYLSIYLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AYK0</accession>
    <name>A0A812AYK0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_7611</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000245">
        <property type="protein sequence ID" value="CAE1163244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AYK0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1163244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="329" mass="39471" checksum="DB929593AB50CAFE" modified="2021-09-29" version="1">MITLRLKLNRKLFRLGEIFKSVFNLSSSFRYFSLSYSFLYFRLSSSVSYVSLSSSFISAYHPPFDISASHPPLFQPIILLSLYHTPLIISTYHLPFFISAYHPPLFQPIILLSIFQPIFLLLLFQPIIFLLSFFQPCKKNIHSLFVQLSFFLASFLFFSVCLIFTAVFFFFGLISDSLYLNFHCFFSSFFLYLFISIAFFIIYIAFCLSSFHFLSFFLSFFLLSLFLLFSFFDHFHCFHSFFYYFSIIILFSFFLFLYFSISFFLSFFLLSLFPLLSFFPLLSFFHHFIFFLSFFLSFFLSFFFFRSVRLFLLPPLIYFHISQRLIRTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B0K1</accession>
    <name>A0A812B0K1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_9208</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000294">
        <property type="protein sequence ID" value="CAE1166997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B0K1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="388"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="413"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="438"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="471"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="553"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="581"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="618"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="654"/>
            <end position="687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1166997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="689" mass="82609" checksum="71F6303919064E89" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B2T4</accession>
    <name>A0A812B2T4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_9179</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000294">
        <property type="protein sequence ID" value="CAE1167087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B2T4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1167087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="280" mass="34190" checksum="7808506EAC729457" modified="2021-09-29" version="1">MSFFISNLFFLSFFLSFCLSNVFFSSFFHHLFQMYSFLTSFLPSFLLSFPPSFFQVYSFYLLNFFFLLNIFLLSFFLSFFLSFFQIYSFYLLNLFFLSFNYIPSFFLSFFLSFKSIPSFFVSFFLSVYLSLSLYIDFRHALLFSFFLSFFLSFFLSFFLSFFLSFFLFVYISINFQIDFPIYTHFSHPLPSFFLSFFLSFFLSLFLYLFLSFRSLPSFLFLSLFLSFFQMSFISLFLVTVYFLFYYCLYIHIFSFFVIFFLSFFLSFFLSFFLLLLLLPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B336</accession>
    <name>A0A812B336_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_9211</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000294">
        <property type="protein sequence ID" value="CAE1167008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B336"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1167008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="236" mass="28034" checksum="F0546DEDB8898EAE" modified="2021-09-29" version="1">MGQIRGHSAISVPLRLSSTFPLPIQDQIATRIEGTHLSIYLSIYLSIYLSIYLSIAVYSYLSIYLSQSVVITLSLFISVYLSIYLSIYLSIYLSQSIHIYLSIYFNLLLYLSIYLSQFVITLSLFISIYLSIYLSIYLSIYFSQVISIYLSIYNNECSNVRICIIINIYHSIYLSIYLSIYLSMYFHFFHFSYFFSFPFFFNLFYRRFSLFFLSLFLSVFLIFFFLFLFPSLFEVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B356</accession>
    <name>A0A812B356_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_8360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000270">
        <property type="protein sequence ID" value="CAE1165225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B356"/>
    <dbReference type="OrthoDB" id="9942939at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1165225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="152" mass="17352" checksum="01B0BFEA9CDAE7DA" modified="2021-09-29" version="1">MWFREEPTSPNVNVLTEELTSLKFYVVPEEPTYTKSQCGYRGTNLTEVLCGPRNQPTVTDEIQLPLTEFYVVPEKQPTRKSMVTEELTSLKFYVVPEEPTHTKVNVIYRGTNLTEVLCGLLQCGYRGGTNLTEVLCGPRGTNPRMSMWLQRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B5R3</accession>
    <name>A0A812B5R3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SPHA_10597</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000343">
        <property type="protein sequence ID" value="CAE1169430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B5R3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033053379" evidence="3">
        <location>
            <begin position="19"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAE1169430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="236" mass="25802" checksum="4D91F024E1C05410" modified="2021-09-29" version="1">MTVGFSLSLSLSLSLSLSLSLSLCVCVCVCVSLWLTFFLSLSTSKSITLSLPLSLTHSLSPALSFELTFYVTLSLSHLSLSLSLSSRSLPRCHSISYSLFHSDPRTLTLYLTHSLSRTHSLSPSLSLSLSLSNSITHTLSRIHSIFPSLFRNLILSQSLSLSLSLSLSQSFTLSSSQQKCLVRIFATTTEICTRIRLHPGSRPRLPCSARRAPTRRVHEKTDPDPGAAMNAEPAFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B8X9</accession>
    <name>A0A812B8X9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_13108</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000436">
        <property type="protein sequence ID" value="CAE1174402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B8X9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1174402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="150" mass="17585" checksum="CCB48B3E3B30135E" modified="2021-09-29" version="1">MDLSLLNENRLQANDTTEGDRRIRYHSVRGNAELSFLVSPKKECQIGKDSQNTTERHLSLFISIYLSIYLSRAYLSKSCISIYLSIYLSIYLSIYLYFIFLSIYLSIYLSIYLYVCASLFVSIFSLVLFLSVSFSLFMPIYLFKKFFDRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BAP4</accession>
    <name>A0A812BAP4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_13817</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000465">
        <property type="protein sequence ID" value="CAE1175787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BAP4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134:SF22">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134">
        <property type="entry name" value="OS08G0543275 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1175787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="244" mass="29116" checksum="8F29E5DB3C2DF3CB" modified="2021-09-29" version="1">MIYLAANLFIYIDINVASLISLFIFISPSLSLHLSLFLSIYLSIYLSIYLSIYLSACLSVYLRLDSYLSLFSPIYLSIYLSLLVSISACSYLSIYLSIYLSIYLSIYVSIYLSIYLYIYIYIYIYIRVYVCMYVFMNIYLSIYLSIYIYIYIYIYIYPSLCMYVCIYEYLYLSIYLSIYLSIYLSVHFFLSNSCYFLSVYLNLFLSIYLSIYLFIFIYLSILFLFISLYIYLSIYLSIYLSLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BCZ9</accession>
    <name>A0A812BCZ9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AJUBA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_14551</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000497">
        <property type="protein sequence ID" value="CAE1177257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BCZ9"/>
    <dbReference type="OrthoDB" id="6135526at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035331">
        <property type="term" value="P:negative regulation of hippo signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001666">
        <property type="term" value="P:response to hypoxia"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047172">
        <property type="entry name" value="Ajuba-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24219">
        <property type="entry name" value="LIM DOMAIN-CONTAINING PROTEIN JUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24219:SF4">
        <property type="entry name" value="LIM DOMAIN-CONTAINING PROTEIN JUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="564"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="599"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="636"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="56"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="130"/>
        </location>
    </feature>
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            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="438"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="493"/>
            <end position="524"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
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        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
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        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
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        <location>
            <begin position="97"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="177"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="380"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="493"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1177257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="668" mass="70638" checksum="E917B9729F0C55A0" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BFB4</accession>
    <name>A0A812BFB4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_17381</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000620">
        <property type="protein sequence ID" value="CAE1229679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BFB4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1229679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="185" mass="21736" checksum="38C05EF45AF1DCC6" modified="2021-09-29" version="1">MTLIYLSIYLSIYLCLFISIYLCISLSLSLYIYIYIYIYKILFISMYSSLSIHVDDTLSIYLSIYLSIYLSMKFCSYLCSCLSMYLSIYVSSLSIYIDDSYLSIYLSIYLSIYLCLFISIYLSVYLCIYLYMSVHYLYISMTLIYLSIYLSMSVHIYLSICQSVCLPIYLSIYVSSLSIDDYLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BFG3</accession>
    <name>A0A812BFG3_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mediator of RNA polymerase II transcription subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Mediator complex subunit 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MED4</name>
        <name evidence="10" type="ORF">SPHA_19091</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Farmed</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000691">
        <property type="protein sequence ID" value="CAE1233747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BFG3"/>
    <dbReference type="OrthoDB" id="1929813at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019258">
        <property type="entry name" value="Mediator_Med4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13208">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13208:SF2">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10018">
        <property type="entry name" value="Med4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="173"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="253"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAE1233747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="264" mass="29069" checksum="9BA4DFF105A4DF2E" modified="2021-09-29" version="1">MAAISTKQKLLTLIDDIEIVSKELFDVMSTPKNQQKQDTPDPGLLMELLVQKDKEIKESLKLAEEQMEIQKITDDLKLEVDKRDTDIKNFQKNLKEAETILATAIYQAKQKLNSIAQANKKTISSEELIKFAHRISASNAISAPVTWAPGDPRRPYPTDFEMRHGFLDHMQNAQSGSMSWQSSSLQPPPPVPPQPPPSSVPLLDPPPPMFGLTNSAHNSCLPTSVSAMASSAGLSESIRNHTSRDNEDVEIMSSDSSSSSSSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BGP5</accession>
    <name>A0A812BGP5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_17177</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000610">
        <property type="protein sequence ID" value="CAE1229223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BGP5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1229223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="269" mass="31115" checksum="2E0AD4F325B283BD" modified="2021-09-29" version="1">MRREKFSSILRYFLLCSIFTRMRQICGLVPDFASIYLQLPSNRRSVSFYACVRTVYLKRNARESTAHTLPTAHTQRNFSLRHSFICLILLFVTSFLYSSIRLFAHSYSYSGTLCNTVRRSNLLQFFYLETLSISLTQPMKNLSIYLSIYLSIYLSIYLSINLSFYSLAVKKHQAICMETNLAIYLSIYLSIYLSIYQFLTIQYLSISIYLSINQSHLTANCFRPRRVPSLLLFRYTDISTRAFVVECLLTSPSRSSLSFGPASLGARLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BGY1</accession>
    <name>A0A812BGY1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_17354</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000618">
        <property type="protein sequence ID" value="CAE1229561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BGY1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1229561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="208" mass="24590" checksum="E74FAFBF3C657E6B" modified="2021-09-29" version="1">MLNFVYYLPIYISIYLSIIYRSIFDDLSVIYLSIYLSLAISPLSIYLSIYFWRSLHYLSIYLSILSIYLSIFDLFILHSIYLSIYLSYLSYLSLISIIYLFILYLSIFILSIQTSIYLSIFGDLIYLSIYLSIYLWRSLHYLSIYLSIYLSIYLSLAISSFSIYLSIYLSIYLSIYLLISPIYPSIYLSIYLSLAISSIYLSIYLSIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BHB3</accession>
    <name>A0A812BHB3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_18618</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000670">
        <property type="protein sequence ID" value="CAE1232602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BHB3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1232602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="351" mass="39146" checksum="98C293BED6C877CA" modified="2021-09-29" version="1">MTFSILLAFFISLTPTPLSLFLSLSLSLSIYLSIYLSISFFHPYISFLFLLLLFLLMFFCSTLPPLLSFSLTLSYSSLSLSSLSFNPSLFHSSTPSLFLSLSLSPTHLLPLFSILFISLSLSVFSFFNLSSTFPSIHSLFFSLSFSLLFIFSHFLSVSLALSLSLSLYLSLSFFTFLIFYCSTLPFLLSLSLSLSLSIFSLLLFICPFFLSLSLLLIFSPLYLSFFSLSLIFSRSLSVPFSLSLSSTHLLPLSICPFFLSLSLLLIFSRSLSVPFFLSLSPTHLLPLSICPFFSLSLPYSSSPPLYLSLFSLSSPHSSSPALYLSFFFFLSPYSSSPPSLSVPFFSLSLFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BJH3</accession>
    <name>A0A812BJH3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_21501</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000789">
        <property type="protein sequence ID" value="CAE1238797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BJH3"/>
    <dbReference type="OrthoDB" id="6149882at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="363"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="393"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="435"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="464"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="487"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="513"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="547"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="576"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="684"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="714"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1238797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="740" mass="83412" checksum="17B42B5102554CB9" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BQV8</accession>
    <name>A0A812BQV8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_21075</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000776">
        <property type="protein sequence ID" value="CAE1238096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BQV8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032808151" evidence="2">
        <location>
            <begin position="28"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="353"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="376"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="439"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="475"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="503"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1238096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="551" mass="60251" checksum="03B7F7557127A113" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BSF6</accession>
    <name>A0A812BSF6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_21933</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000807">
        <property type="protein sequence ID" value="CAE1239709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BSF6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1239709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="202" mass="23111" checksum="3CD76FDA886B700F" modified="2021-09-29" version="1">MLHSPSLLSLFPYTFTLSSLSFSLNIFFLSSRFQLFSLFPLSQCLFPSLQISTFLSFPSLFFSQYLCPSLHISIFLFFLPFSFQLFSLFPSLLILNFLSFSSLSLNIFFLPDTFRLFSLFPLSQYLFSSLLILTFLSFSPLTISVTNSLDFPFFINSFFSLLYVLSFSGEINQQPSSSCPSIPYFEASHAKCNWDSLAFTAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BV74</accession>
    <name>A0A812BV74_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_22324</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000824">
        <property type="protein sequence ID" value="CAE1240435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BV74"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1240435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="201" mass="22782" checksum="059E4D3DB940763B" modified="2021-09-29" version="1">MTWRKSSPVFHIFSLLCFLSLLLPFPSLSLFILPTIYLSIYLSNTISINRKFSSYPFHNFVFPFLSLSISLSFCLSVFSLYLSLTKFVILSSFSLSLIFCSVSLCLFVCLSLSLSFSLSLHPSLAPPLSYSRSNVYHSFPLSSFFLCFYLYLSLASSLPLSLPLSFSPPLVLEEFPSIFPLSFYYFSLYPSFYLSISSPNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BXI7</accession>
    <name>A0A812BXI7_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peptidase metallopeptidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SPHA_25381</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Farmed</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="8">Can bind about 5 Ca(2+) ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M10A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000960">
        <property type="protein sequence ID" value="CAE1246881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BXI7"/>
    <dbReference type="OrthoDB" id="406838at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030574">
        <property type="term" value="P:collagen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04278">
        <property type="entry name" value="ZnMc_MMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033739">
        <property type="entry name" value="M10A_MMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001818">
        <property type="entry name" value="Pept_M10_metallopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021190">
        <property type="entry name" value="Pept_M10A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201">
        <property type="entry name" value="MATRIX METALLOPROTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201:SF331">
        <property type="entry name" value="MATRIX METALLOPROTEINASE-14-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00413">
        <property type="entry name" value="Peptidase_M10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00138">
        <property type="entry name" value="MATRIXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="PGBD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033027262" description="Peptidase metallopeptidase domain-containing protein" evidence="9">
        <location>
            <begin position="22"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase metallopeptidase" evidence="10">
        <location>
            <begin position="98"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <feature type="binding site" description="in inhibited form" evidence="8">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR621190-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR621190-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAE1246881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="272" mass="30888" checksum="527BC5CFC921634F" modified="2021-09-29" version="1">MKTLFCCIFTLTAIFATSVFAQVEPQDFLLQYGYLKEKTGANRAENPTPEEMQKAIIAFQRFTGLPQTGVMDDTTSKKMIAPRCGVKDITGKLGEYRAVSKWPKKLITWKIHKYSKTSKLSPAEQKRAIRRGLKRWAQVTPLYFRETGGKPTLDISFEKEKHGDGHAFDGIGRVLAHAFFPRNGDTHFDDDEIWVNGGDTGTDLETVAAHEFGHALGLGHSTESRSLMAPFYQKFPDNFRLHPDDIAGIQKLYGKWFDFYFLRYSSGDYHSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BXQ0</accession>
    <name>A0A812BXQ0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UNC5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_25477</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000966">
        <property type="protein sequence ID" value="CAE1247103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BXQ0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1247103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="254" mass="29643" checksum="391E848F3D972E38" modified="2021-09-29" version="1">MQYARTLALRGTSHTGKRENPSYVRFRYAYTNKSHYCACTSAPFSRVWRSKSDTLSIDAISKAFLLPVEAVTSVTYPRTTPTTGPADDKACLTNSIPLSLFLSFFLSFFLSFFLSLSLSQGHKLTSIQPIIDSFILSFFLSSFISIKYFLFCAFILSFFLSIFPYLNIKFLLLFILFSFFLWPLIKIFSLSFFLSFIISFFFPFFLSFFLSMVIYLNKILSFCTFINSFIQLFFLFPFFFLFSFLRSLFLRPFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BXZ1</accession>
    <name>A0A812BXZ1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_27579</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001077">
        <property type="protein sequence ID" value="CAE1251590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BXZ1"/>
    <dbReference type="OrthoDB" id="6819399at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1251590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="248" mass="28283" checksum="612C806A8746499A" modified="2021-09-29" version="1">MFSVSTDQSLSLDVGDFFTIPCCKTHLGESVHIYLSILVCSYLSIYLSLFTSIYLFILSVHIYLSIYLNLFTSIYLSIYLSLLTSNYLSIYLSILVCSHLSIYLSLFTSIYLSIYLSLLTSNYLSIYLSILVCSHLSIYLFILSVHIYLSIYLSLFTSIYLSILSVHIYLSIYLSLFTSIYLSIYLSLFTSIYLSILVCSHLSIYLSLFTSIYLSILVCSHLSIYLSLFTSIYLSILVCSHLSITKPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BZV6</accession>
    <name>A0A812BZV6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_25926</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000988">
        <property type="protein sequence ID" value="CAE1247986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BZV6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1247986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="167" mass="18916" checksum="71C08B7BD8271B3D" modified="2021-09-29" version="1">MRIIDNQFDLYLSIYLSIYLSIFLHLHITESIHIYLSIYLSIYLYQSVHIYLSTLLFGSHDVGTYHPPRSSSSLIDIDAIAVAAGVTTTTTTVSLAAVAQIHRSPTFCPLNGTFSLTICLSLFLYLSIYLSIYLSIYLSIYLLMFISIYLSIYLSIYLSIYSPPSHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C0I5</accession>
    <name>A0A812C0I5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_27149</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001045">
        <property type="protein sequence ID" value="CAE1250532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C0I5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="282"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="317"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="399"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="428"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="469"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1250532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="493" mass="59591" checksum="B3F9F3DB3961211C" modified="2021-09-29" version="1">MSFFFLFYLSHFFFSLVSTSFFFSLFFSLSLILFPYFYTISSFSFHFFFFLVFTFYYHYYILLFCLGLIHVFSSFTFPSFSSLSFSYYPFFLFVPNSAIAYPYVSFFYFLRSLSFYLFPYFSIVSLFFLFIPRSLSFSSRPGFFLISTILPFFLFFYLRISSFHLLFSLFPDVLSYFPCYLFLFYSFLFDSIFLFCLFLTFTICVHFLFHCSNFISFLLILSFSFWLFFLPYLFSHFLPPPDFFRNLFTLFPLVHSSFFSDFFSHCYVAYFTSFLFHLYLRFPLSFTSLTFTSFSIFPCSFSLFLSSSPLLRLSQFFICPYLFFIFSFFVIPSFILAFVLRFHTSLLFRSFSPVFSFSTCLFLLPSFSMVNSCSLFFSSFTLFLFLIFSSVSFSNSSSFLFLIFLLLFLYLLCLYLIYLIFIFNISSFFFFFFFFFFFFFFFFFTYHLLKSFFTFFLSFSDPFLYPYFYLSSLSSLNHSFFVSLLISFPHLLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C0R6</accession>
    <name>A0A812C0R6_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">rRNA methyltransferase 2, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SPHA_26188</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001001">
        <property type="protein sequence ID" value="CAE1248558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C0R6"/>
    <dbReference type="OrthoDB" id="20105at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008650">
        <property type="term" value="F:rRNA (uridine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902775">
        <property type="term" value="P:mitochondrial large ribosomal subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000129">
        <property type="entry name" value="Mitochondrial rRNA methyltransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01547">
        <property type="entry name" value="RNA_methyltr_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050082">
        <property type="entry name" value="RNA_methyltr_RlmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015507">
        <property type="entry name" value="rRNA-MeTfrase_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920">
        <property type="entry name" value="RIBOSOMAL RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920:SF18">
        <property type="entry name" value="RRNA METHYLTRANSFERASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="10">
        <location>
            <begin position="106"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAE1248558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="299" mass="33680" checksum="9A7236890075AD43" modified="2021-09-29" version="1">MLKLLRQIIPFLAIVRPVFWISDSTNIELSFFLSLSLALWIIPDDCASVMSLKFWKCLKRYFSSSSKLRKHSSKPHNLKGKSTSSQKWITRQLKDPYVKRAREESYRCRSAFKLVEIDDRFDLLRPGSVVIDCGAAPGSWTQVAVERVNAAGTAKSQKEGCVISIDKQFMVPVKGAITLATMDFTKGQTQNKVLEVLSGRKADIILSDMAPNTTGIRSMDHDLIIELCFSVLEFSRTVLRPDGALLCKLWQGHEQKELEQRLGDVFQTVKIIKPQASRGDSAEIFLLGKGYTPNKSHIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C2F7</accession>
    <name>A0A812C2F7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_27148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001045">
        <property type="protein sequence ID" value="CAE1250538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C2F7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="295"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="325"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="380"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="408"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="438"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="470"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="497"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1250538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="533" mass="64557" checksum="F88934FD75BA521D" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C5B2</accession>
    <name>A0A812C5B2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ABCD3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SPHA_27317</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001054">
        <property type="protein sequence ID" value="CAE1250922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C5B2"/>
    <dbReference type="OrthoDB" id="422637at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015910">
        <property type="term" value="P:long-chain fatty acid import into peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042760">
        <property type="term" value="P:very long-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03223">
        <property type="entry name" value="ABCD_peroxisomal_ALDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000636">
        <property type="entry name" value="ATP-binding cassette sub-family D member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050835">
        <property type="entry name" value="ABC_transporter_sub-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384:SF62">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY D MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384">
        <property type="entry name" value="ATP-BINDING CASSETTE, SUB-FAMILY D MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06472">
        <property type="entry name" value="ABC_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="89"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="418"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAE1250922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="637" mass="73140" checksum="2E7B3D33E4311B83" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C5I8</accession>
    <name>A0A812C5I8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_30003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001203">
        <property type="protein sequence ID" value="CAE1256144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C5I8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1256144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="188" mass="21183" checksum="3EA4AFD2FB3DAEC1" modified="2021-09-29" version="1">MYLSLLLSISLSLSLFLSLYLYFSSSVSHFPSPFLTLFLSYHGIHIFHKCNAYTFSHFLSLSVSLSLSLCLSLSLSLYIYIYIYIYTNSLSSSQTLSLSLSLSLSLSLTLSLSLSLSLSLSLSYTSVCSHLFFSFSVLISFRFSWTLISSFSPPSLILSFNTQCASQYFPSLYICFFLTFLLPFSRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C5X3</accession>
    <name>A0A812C5X3_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prostaglandin reductase 1</fullName>
            <ecNumber evidence="4">1.3.1.48</ecNumber>
            <ecNumber evidence="5">1.3.1.74</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">15-oxoprostaglandin 13-reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Dithiolethione-inducible gene 1 protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Leukotriene B4 12-hydroxydehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">NAD(P)H-dependent alkenal/one oxidoreductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="36" type="ORF">SPHA_30203</name>
    </gene>
    <organism evidence="36 37">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="36" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="36">Farmed</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="31">
            <text>(5S,12S)-dihydroxy-(6E,10E,12E,14Z)-eicosatetraenoate + NADP(+) = 12-oxo-(5S)-hydroxy-(6E,8E,10E,14Z)-eicosatetraenoate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51212"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:133974"/>
            <dbReference type="ChEBI" id="CHEBI:133975"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="31">
            <dbReference type="Rhea" id="RHEA:51213"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>13,14-dihydro-15-oxo-PGF2alpha + NADP(+) = 15-oxoprostaglandin F2alpha + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50588"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:133374"/>
            <dbReference type="ChEBI" id="CHEBI:133409"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="27">
            <dbReference type="Rhea" id="RHEA:50590"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="32">
            <text>13,14-dihydro-15-oxo-prostaglandin E1 + NADP(+) = 15-oxoprostaglandin E1 + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50584"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57401"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:133408"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="32">
            <dbReference type="Rhea" id="RHEA:50586"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>13,14-dihydro-15-oxo-prostaglandin F1alpha + NADP(+) = 15-oxoprostaglandin F1alpha + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50592"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:79072"/>
            <dbReference type="ChEBI" id="CHEBI:133411"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="24">
            <dbReference type="Rhea" id="RHEA:50594"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>20-hydroxy-leukotriene B4 + NADP(+) = 12-oxo-20-hydroxy-leukotriene B4 + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51208"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57460"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:133346"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="29">
            <dbReference type="Rhea" id="RHEA:51209"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>4-hydroxynonanal + NADP(+) = (E)-4-hydroxynon-2-enal + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:64736"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58968"/>
            <dbReference type="ChEBI" id="CHEBI:156112"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="28">
            <dbReference type="Rhea" id="RHEA:64738"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="30">
            <text>6-trans-leukotriene B4 + NADP(+) = 12-oxo-(5S)-hydroxy-(6E,8E,10E,14Z)-eicosatetraenoate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51204"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:90723"/>
            <dbReference type="ChEBI" id="CHEBI:133974"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="30">
            <dbReference type="Rhea" id="RHEA:51205"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="33">
            <text>an n-alkanal + NADP(+) = an alk-2-enal + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13737"/>
            <dbReference type="ChEBI" id="CHEBI:12834"/>
            <dbReference type="ChEBI" id="CHEBI:13757"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.3.1.74"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="33">
            <dbReference type="Rhea" id="RHEA:13739"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>decanal + NADP(+) = (2E)-decenal + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50612"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:31457"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:133455"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="21">
            <dbReference type="Rhea" id="RHEA:50614"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>dodecanal + NADP(+) = (2E)-dodecenal + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50784"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:27836"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:133741"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="25">
            <dbReference type="Rhea" id="RHEA:50786"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="34">
            <text>hexanal + NADP(+) = (E)-hex-2-enal + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50776"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28913"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:88528"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="34">
            <dbReference type="Rhea" id="RHEA:50778"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>leukotriene B4 + NADP(+) = 12-oxo-leukotriene B4 + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50608"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57461"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:133309"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:50609"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>nonan-2-one + NADP(+) = (3E)-nonen-2-one + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50616"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:77927"/>
            <dbReference type="ChEBI" id="CHEBI:133457"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="26">
            <dbReference type="Rhea" id="RHEA:50618"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>octanal + NADP(+) = (2E)-octenal + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50780"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17935"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:61748"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="20">
            <dbReference type="Rhea" id="RHEA:50782"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>pentan-2-one + NADP(+) = (E)-pent-3-en-2-one + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50788"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16472"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:145276"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="22">
            <dbReference type="Rhea" id="RHEA:50790"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer or homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NADP-dependent oxidoreductase L4BD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="36">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.48" evidence="4"/>
    <dbReference type="EC" id="1.3.1.74" evidence="5"/>
    <dbReference type="EMBL" id="CAHIKZ030001213">
        <property type="protein sequence ID" value="CAE1256472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C5X3"/>
    <dbReference type="OrthoDB" id="809632at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047522">
        <property type="term" value="F:15-oxoprostaglandin 13-reductase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032440">
        <property type="term" value="F:2-alkenal reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006693">
        <property type="term" value="P:prostaglandin metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08294">
        <property type="entry name" value="leukotriene_B4_DH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000121">
        <property type="entry name" value="Prostaglandin reductase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041694">
        <property type="entry name" value="ADH_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045010">
        <property type="entry name" value="MDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014190">
        <property type="entry name" value="PTGR1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205:SF7">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16884">
        <property type="entry name" value="ADH_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="15" id="KW-0379">Hydroxylation</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0521">NADP</keyword>
    <keyword evidence="13 36" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0644">Prostaglandin metabolism</keyword>
    <keyword evidence="37" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="35">
        <location>
            <begin position="18"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00032255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00032297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00033119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00047617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00047742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00047871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00047878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00047903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00048066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00048290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00048387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00048591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00048953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00049068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="ARBA" id="ARBA00049070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="ARBA" id="ARBA00049179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="ARBA" id="ARBA00049368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="35">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="36">
        <source>
            <dbReference type="EMBL" id="CAE1256472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="37">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="328" mass="36026" checksum="A131B758DAE8CD4C" modified="2021-09-29" version="1">MVIAKKWILSKYFDGKAKASDIKLETEELSETLKDGEILCEAVWLTVDPYMRIFIDSIKEGEVMFGSQVARVLKSNNSKYPEGTYVLGQMGWCTHSIVSNESQVEKLPEMGDLPLSLALGIMGMPGMTAYFGFLEKCEPKAGEIVLVNAAAGAVGSAVGQIAKIKECKVIAFAGTAEKCTWLKEELGFDHVFNYKCTDLDKALSTVAPEGIDCYFDNVGGDFTSTVLKHMNSLGRVCICGSISAYNSQAPPSGPYPFLDILTKKLTVRGFLIFSYSDRFHEGQKQMLEWIQSGLVKYKETVTEGFENMPSAFFGLFEGHNIGKAVVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C7C1</accession>
    <name>A0A812C7C1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_30902</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001247">
        <property type="protein sequence ID" value="CAE1257646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C7C1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="305"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="330"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="360"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="385"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="421"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="452"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="497"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1257646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="520" mass="60143" checksum="8472655D14B84755" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C844</accession>
    <name>A0A812C844_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_31239</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001275">
        <property type="protein sequence ID" value="CAE1258455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C844"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1258455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="195" mass="21850" checksum="83A0249A77C21146" modified="2021-09-29" version="1">MTTEVISATVTLKPDNLSLICTNPDYQYIRHPLDCSRWFHCSHEQPVEMPACVDTFSMISLTCLTKQNENNDCISTCIFDGKLHYLGEIFVGRNSCEICICQNNRGTVVCSSACLTKGGNSDKILHSLSRWIFAKDSRISIYLSIYLSIYLSIYLSETIYVAGKTFLHLDGQQTCTCRVDGIVSCSFSHVEQTEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C8E3</accession>
    <name>A0A812C8E3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_31401</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
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</entry>
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</entry>
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        <lineage>
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            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
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            <authorList>
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                <person name="Bekaert M."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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    <comment type="function">
        <text evidence="7">Non-catalytic component of a structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. Responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL). Participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can result in cytokinesis failure. Also required for homology-directed repair (HDR) of DNA double-strand breaks, in conjunction with SLX4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERCC1/RAD10/SWI10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001417">
        <property type="protein sequence ID" value="CAE1263525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CFG2"/>
    <dbReference type="OrthoDB" id="10262814at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070522">
        <property type="term" value="C:ERCC4-ERCC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000110">
        <property type="term" value="C:nucleotide-excision repair factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032204">
        <property type="term" value="P:regulation of telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070914">
        <property type="term" value="P:UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22325">
        <property type="entry name" value="ERCC1_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000017">
        <property type="entry name" value="DNA excision repair protein ERCC-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10130:FF:000001">
        <property type="entry name" value="DNA excision repair protein ERCC-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047260">
        <property type="entry name" value="ERCC1-like_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004579">
        <property type="entry name" value="ERCC1/RAD10/SWI10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00597">
        <property type="entry name" value="rad10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12749:SF0">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12749">
        <property type="entry name" value="EXCISION REPAIR CROSS-COMPLEMENTING 1 ERCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14520">
        <property type="entry name" value="HHH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03834">
        <property type="entry name" value="Rad10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC1-like central" evidence="10">
        <location>
            <begin position="135"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="44"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="51"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="72"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00054210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00071993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAE1263525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="354" mass="40025" checksum="4D29107C2C3D0630" modified="2021-09-29" version="1">MFDNSPYNMAGKSKFRIPSLKEMEKPDDKLVPVFSTYKQNISLSSDEKLNLSKPKSPSKHPVPLQAEPFIKSVSSETLPSRNTPATSSNTQPKPSALNTNVTKSVSVAKQETAKHDQQPKSTASEIPVTKQSTNSIIVNTRQRGNPILKGIRNVPWEFGNIVPDYEMGKASCALFLSLRYHQLHPEYIHTRLKSLGKSYDLRVMLVQVDLKDPHHLLKELSKMCILAECTLILAFSPEEAGRYLETYKVYENKPPDMIMEKSEHDYMSKLTDCLTTVKSVNKTDCVNLISSFKSVESIIKSSRESLSFCPGLGPRKAQRLYEVFHEPFLRKRKRVSNENIQSESPKKFQKTASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CHK3</accession>
    <name>A0A812CHK3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_35013</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001502">
        <property type="protein sequence ID" value="CAE1266046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CHK3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1266046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="305" mass="34418" checksum="9CCE69A7D684D3AE" modified="2021-09-29" version="1">MCSYKIHLRKYPFSLSLTLSRSLTVLSLSHSISVLSHTYPQSVTFLSYTPVARLYLSHSPLIFCFMPLSHSVTYFTLPLPLFPLTHSYNLFSRINPLFFSFSHAPFPPPSLLYISLIIPAVFISFSQFSLSYSLISLTPLSLSFISLKLLSLSFQSLSCSPRNIMSLSHSPSYFLFLTLTFPLPLISISENPPLSFSLSLSLYFLSHTLYFLALTQLFFSLSQTTPFSFVSQTLSFISISLTPSFPILLTPKDSFFFLFGTLFPSLSFLSHAFYFSLSHTLSLYASRSLSLCIYIYVSVCMLQGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CMB0</accession>
    <name>A0A812CMB0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">SOX4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SPHA_41639</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002010">
        <property type="protein sequence ID" value="CAE1279142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CMB0"/>
    <dbReference type="OrthoDB" id="6247875at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007420">
        <property type="term" value="P:brain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22029">
        <property type="entry name" value="HMG-box_SoxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000007">
        <property type="entry name" value="Transcription factor SOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017386">
        <property type="entry name" value="SOX-12/11/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050140">
        <property type="entry name" value="SRY-related_HMG-box_TF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270">
        <property type="entry name" value="SOX TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270:SF323">
        <property type="entry name" value="TRANSCRIPTION FACTOR SOX-14-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038098">
        <property type="entry name" value="SOX-12/11/4a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HMG box" evidence="8">
        <location>
            <begin position="48"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="6">
        <location>
            <begin position="48"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="118"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="125"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAE1279142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="415" mass="44465" checksum="77D1D56F4F57B4B5" modified="2021-09-29" version="1">MVPQNTSIITSAGATVAASLLFGSQLVDPSSHTPYTDATNCKKSSNHVKRPMNAFMVWSQIERRKISEVQPDMHNAEISKRLGREWKLLNEIDRKPFVDEAERLRLLHMQEYPDYKYRPRKKAKAGGGKSDGTSSGGAGVKASKISCKSQKGEKAKQKLGGTANNGIVKSSTLNTNSVNTANRLKLKLTIDKKFKESIKASKSVAVPASQLTPPAKVPSSPSIYTPSTPETVSFYPEEVFETPAASPQEQTTYKVIQGLPVGGAGAGIVGASNIVGGITVGSGASSLVGISAVEGKVFHQQITLPLTTAGTTTTTTTTTQLTTNHPVVVADHQVDNAPLADLDNLTDVLQLPSNWQLELGNLDLSKLADADFNLDVQSQVNSNGSHFEFPDYSTPEVTEMIESDWLETGITPLIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CMI4</accession>
    <name>A0A812CMI4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CACNA2D2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_40202</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001898">
        <property type="protein sequence ID" value="CAE1276744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CMI4"/>
    <dbReference type="OrthoDB" id="10054666at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005245">
        <property type="term" value="F:voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12912">
        <property type="entry name" value="PDC2_MCP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000007">
        <property type="entry name" value="Calcium voltage-gated channel auxiliary subunit alpha2delta 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051173">
        <property type="entry name" value="Ca_channel_alpha-2/delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10166">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10166:SF67">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="1"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1276744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="459" mass="52161" checksum="ED8677D240AACBAD" modified="2021-09-29" version="1">MIIIDTSGSVHGQALQLIKVAVKSLLDTLGENDFVNIAHFSKEAQFVSCFNDTFVQANYRNKKILTKAVENLTAQDMANFKVGFEFAFLQFEKFRNMSKQNGVGAQCNEVIMLLTDGGTDNAKEVFEKYNWSKNKTVRVFTYAVGPTANPTSAIRWMACGNRGFFSQIPAMGAIRSKVQHYIGVLARPLALNHSEYIKWAGVYQDSHGLGMMTTVTLPVYNRTAGANNQTILGVMGVDITTDDMLKKIRRHQLGPTGYAFAINRNGYVVFHPNLKIPKDWNKDPPNVDFLEVEVENEDKELLRRRMIDGETSTVKIRTFVVSPEGNHVWIENRTYSFTPINETSFSLCVTVPTDLKSYMQPLGITEIEGKSLLRSNLSAMLVAPWDYYNGYTQEINITMTTDDLINVLDNSDYKFDTHLMQLLYWDANITKKMELYWNDVDKINSFKFVSFTFLFLITI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CNP8</accession>
    <name>A0A812CNP8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_37831</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001700">
        <property type="protein sequence ID" value="CAE1272805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CNP8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1272805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="172" mass="18510" checksum="46421C3CD8ECA5A8" modified="2021-09-29" version="1">MHRLQQPTLHLGLPRLITKGSFVMDTAATASTRAAETPLHRSVRNATNGATTARSRAVETPAHRRTRQARDAAATATARAAETPSIDLHVNPGTPAALATARAAETLLCRSVRNARNTTTTARSRATETIDHMHTRQSRDAAATARSREPKTAAAGNPQCPQRCSNFCRQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CNR2</accession>
    <name>A0A812CNR2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_40822</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001938">
        <property type="protein sequence ID" value="CAE1277711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CNR2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1277711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="189" mass="21324" checksum="D013214BBC69D6B0" modified="2021-09-29" version="1">MLFFSLLFILSLSSLFLSFFIFLCTLSSLFLTLSFFLSLSFPLSFSHSLFLTLSHSLFLTLSLSLTFFLSLSLSHFLSLTLSFSLSFSHSLFLTFFLSLSLSHFLSLTLSFSLSFSHSLFLTFFLPFSTISFALSIFIALSLFLPLTLSCSLSLTPLFLSHSSLTFYLPLVHYSFYSLALFAVTFSPFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CP71</accession>
    <name>A0A812CP71_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_38451</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001746">
        <property type="protein sequence ID" value="CAE1273790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CP71"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1273790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="230" mass="27614" checksum="569EF38268824A5D" modified="2021-09-29" version="1">MTSLCLTYGLSITLTLCLIFRCSFLTIMSLPFNLLVFFCTRTVRNNLSVSSFFLSFFSYLGLFIYLSIYLSIYLSIYIYIYIYIYISFFLSFFLSFFFSFFLSFFLSFFLFLVHILLSIYLSIYLSIYLSIYLSIYLFLILFSFLHFFINLRSQKQPHTSIYLSIYLSIYLSIYLSLSLSISLSLFCVDYTFKLEQTYLLLVYYKLYLKKTFFTLCLAIHIEEQKYIVYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CXR8</accession>
    <name>A0A812CXR8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_45713</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002368">
        <property type="protein sequence ID" value="CAE1285942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CXR8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1285942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="300" mass="35393" checksum="D64B96A3F58838F1" modified="2021-09-29" version="1">MLLNKINKYLSIYLSIYLSIYLSIYRAFLSLFTLFIYYYFYSLFLSFHTYYSYYVPSFLSLCYFHFFFFASQSFLLKFLTFSLFLPFIHCFSLSFLTHSFLLGFLRFSVYITFNLSPLNLSYLNFLLCLSFFISFFLSHPHLHTHLFLLHTFFSLFLTLSLSLSFVLFLSFLLFFHPTHSYTFILITCLILLFISLAFIFGFESFLLRLLTLSLSLCLSLIAFLVSIPVLSVSILVCHLSFFCFSLFLSLPTLSALHRYLSLFLPLPPHHRAISFFSYFCKHVFSLYPSAPPLPRLQTVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CZL7</accession>
    <name>A0A812CZL7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_46198</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002434">
        <property type="protein sequence ID" value="CAE1286814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CZL7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="311"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1286814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="344" mass="40321" checksum="2ED8C4ECD5F7B9EC" modified="2021-09-29" version="1">MILKSNVLHFFLLFSTLLYSLLALSLSLSLSLFLSLCLLFIAFFLLHYLSLFFPYFSLSLLSILLLLCPFLSFLLQLACPTFTFLSYSSQSNLFPFSFPRCHFYSFFFITPSFSLSFAFPLSLLFFYTFFFVSLSFFFCVRLSFSLFLSLTHTHTHIPNLSFFCLLFFSFLPAYVIFFFLSSSHSLIMSLSCFIPLYFLRLFFLLFSLFFFIFLSHSLVALFSLIHSLFPTSLSNLTVLSNILSFLSFFLSLSNSLFHACLFLNHYLTYSTFYLYNTFFLFLSTLVFPFFFHTLFSSLPFSLLFTLLNTLLLSLTFFHSFFLFLFFPLSYSLFHPCLSLSYSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CZV6</accession>
    <name>A0A812CZV6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_44921</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002305">
        <property type="protein sequence ID" value="CAE1284739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CZV6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="328"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1284739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="372" mass="46914" checksum="2EA65008D374E87B" modified="2021-09-29" version="1">MTVFFLSFSFLSFLFFLSFFSIPSFSFFLSFFLFFLFLSVFLSDLFFSFFLFYSFFFLSFLFLSFSFLPFLSFFSILSFSFFLFYSFFFFLSFFLYILHPFLFINFILLYYFYFNHFYYILSFFSLFYYILFFFSLFYYILSFLSLFLLYSFLLSVIFIIFFLCFHYFYYILHPFLFINFIILFLYFNHFYYILSFFSLFLIFSFFSLFLLYSSSFFFSLILLYYFFIVIIFIIFYHSFHYFYYILSFLIIFIISFLSFHYFSIFFIPFFSLIILYYFFILIIFIIFFLSFHYFIIFFFLFIIFIVFFFSFLYLLYSFFPSFHYCSLFLFYSILFFLSFFLSFFLSFFLSFFLTVTYISTSLYISFHFFSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D093</accession>
    <name>A0A812D093_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_46978</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002518">
        <property type="protein sequence ID" value="CAE1288211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D093"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="317"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1288211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="388" mass="45910" checksum="754003FA3C58BD7E" modified="2021-09-29" version="1">MTSWNFVLSSLPPILFFVFYFSFHHPDFFFLLYPAPFPPSLFLATDSRHFCSSTSDLKPKRLGAGRLPSLGQVYFFFFLISLSLSLSLSHFSHSLIFLYFLSLVYSSYSPFQVHIALPLSYSLSSLLYSFISYYLFLLSFRLFLYLFVSYVYFRLFLYLFFRLSFRHLFVYLFSLSFRLFLYLFVSSLSFSIFSSLSLSFRLFLYLFVSFSIFSSLSLSFRLFLYLFVSFSIFSSLSLSFRIYFRLFLYLFSNPHLSFSLSFRLFLSFVSFSFRLFFSIFSLSLSFRFFLYLFVSFAYLFRSFIFSSLPFFRVLSLIQYLFVSCLLFVYSFISCPSFFVSFAPQFILPHSLFSPTKLRLLSLHFAARQDALQTHSDLDCIKLTIPCPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D0X1</accession>
    <name>A0A812D0X1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_48132</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002655">
        <property type="protein sequence ID" value="CAE1290225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D0X1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1290225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="385" mass="43436" checksum="10506E748379B61A" modified="2021-09-29" version="1">MHTHISLCTYIHLSLHTYLSLSLYIHTYIYLYVHTYLSTYIHPSISLHTYTHPSIHLSTNIHLSLSHIHPSTFSLYIHTSTSTSIHPHISYIHLSFITSIHLLYIHLSLSLHTSISISTYIYLSLYIHPSLSLYIHPSSLHTSTSLSTNIHLHLSTYIYLSLSLYIHLSLSLSLYIHLSLSLSLSTYIYLSLSLYIHLSLILSLHTYHLSLSLSTSIPLPHTPSLSLSPHTSITPSPIPHTSIPHTLLSLSLHTPSLSLSLHTSISLSPPHTSILSLSLHTSISLSLSTYIYLSLSLHTHTSISLYIHLSSISTLISLHTSIYLSLSTYIHLSLSLYILYISLYIHLSLSLHTYIHLSLYTGNLVIRHCIATGHHYSARNQRARH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D174</accession>
    <name>A0A812D174_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rad60/SUMO-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SPHA_43957</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002225">
        <property type="protein sequence ID" value="CAE1283310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D174"/>
    <dbReference type="OrthoDB" id="442921at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01763">
        <property type="entry name" value="Ubl_SUMO_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052324">
        <property type="entry name" value="NFATC2-Int_DNA_Repair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022617">
        <property type="entry name" value="Rad60/SUMO-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47187">
        <property type="entry name" value="NFATC2-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47187:SF1">
        <property type="entry name" value="NFATC2-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11976">
        <property type="entry name" value="Rad60-SLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad60/SUMO-like" evidence="4">
        <location>
            <begin position="296"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAE1283310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="372" mass="42214" checksum="B21261A42C98DB09" modified="2021-09-29" version="1">MLENSGESYHKPCNNGSSDSSDCEDEPVVKRKRKTLRRVVDPAEILSTNQNQANVYTTVAQKSFEEIHSSKFDFAKYCQEEKVEIEKEEKFKQLKNTFPSEIQDDVLCIESNCSSSGFQPVSFCRSQSPAPPSPPPPVVANPVRTRSFSKITQNLKKIQSSIQKLDKVLNSDPCDIQCLDDSVIIVDDDDKEEENITSSPDAFSREIVVMVKIGSEIKRFPMNKTDTFCNLFSYLAQEKKVPDTRLMLLLNEKTIHQNETPASIQLQVADIIDCLITEEEDPEEFSERTGPNVISLVIQSSINQKSKKTMRIGKFEMLQGIIDLYAKQHKLQAADLKLRFDGEIVDTSQTPADLDMEDEDSVIFFFHNYTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D2W3</accession>
    <name>A0A812D2W3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_46541</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002461">
        <property type="protein sequence ID" value="CAE1287369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D2W3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1287369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="215" mass="26028" checksum="2EE26E9B40A98EC2" modified="2021-09-29" version="1">MICSCHQIVCSCLAMVFYPLISFLFFTLSFPFFFFTLSFPFFFLSSHFLSFFTLSFPFFFLPSHFLFFLNKFISFFFYLSFPFFSKPSHFFFFFYPLISFFFFIYTLISFLFLPSHFLSFFYPLISFLFLILSFSFFYHFLPFINVLFSVFFFTVFCSLIFLSLTCSFSLSSFVLYFIIITSFDLLLFTSSVFLIFFLSHSVFFRLITFCFLHIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D3G3</accession>
    <name>A0A812D3G3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PPP3C</fullName>
            <ecNumber evidence="3">3.1.3.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_46393</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="3"/>
    <dbReference type="EMBL" id="CAHIKZ030002446">
        <property type="protein sequence ID" value="CAE1287164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D3G3"/>
    <dbReference type="OrthoDB" id="5593063at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033192">
        <property type="term" value="F:calmodulin-dependent protein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097720">
        <property type="term" value="P:calcineurin-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043360">
        <property type="entry name" value="PP2B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45673">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="2">
        <location>
            <begin position="254"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1287164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="327" mass="36753" checksum="F50B5CB99EA599CA" modified="2021-09-29" version="1">MTFLKLFHTLTASTVLSDIYLSPLSIPFYSPLSLSLSILPSLYPFLFSPLSIPFYSPSPLSFLPSLSLSILPSIPFLFSPYLYPFLFSLSLSLSFLFSLSPFLSPSLFFSLPSLYPFLFSLSLSLPFYSLSLFSLSLSLSILPSLYPFLFSPLSIPFYSPLSLSLSILPSLYPFLFSPLSVSFILSLQLCVPFPPSHRLTMSEVFDSRGKPKPDVLKQHFVLEGRVTEDVALRIINEGAALLRQEKTMIDIEAPVTVCGDIHGQFYDLMKLFESKLAQKILSVSETQPATNILLSLFPSSGDYVDKEDIFLMHRDFKFLIYIPFKVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D733</accession>
    <name>A0A812D733_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_51043</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003061">
        <property type="protein sequence ID" value="CAE1295703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D733"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1295703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="164" mass="19125" checksum="8262A233B131DE19" modified="2021-09-29" version="1">MPKKPSYSPHRLVINDVQKTFVFTASFCAQLRTKNIPFHYIVRCSTTPKKPSYSPHRLVINDAQKTFLSTTSFGDQRRPKPSYSPHRLVINYVRKPSHSLHRLVINDVQKPSYSPHRLGINDVQKPSYSLHPLVMNDAQKTFLFTTSFGDQRRPKILHIHYIVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D743</accession>
    <name>A0A812D743_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_47261</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002556">
        <property type="protein sequence ID" value="CAE1288772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D743"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1288772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="265" mass="31179" checksum="10E9C3AC519B99C0" modified="2021-09-29" version="1">MSSSKFLLHFFLAISYSNLLHRILFNSSSRILFSSSSQFLIQILFTVSYSILFQGFIFSSSSLILFHGFFLMESSSILLHIFFFNSSSGLLQSFFFCSSSQILFSFLFRTSLQFFLQGFIFNSSSQILLQIFFIDSFSILLHSSISSFILLLQFLQFFFMHSSSRILHQFFFMDSSPIVIHFQFFFRDSLMDLLLLLQFFFSSSSFFFMRSSAWILLQFFLHRILYHFFSILLLQFFFRFFFNSSSCILLHGFFSIVVQNSSSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D8Y2</accession>
    <name>A0A812D8Y2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_48236</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002666">
        <property type="protein sequence ID" value="CAE1290496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D8Y2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1290496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="234" mass="27161" checksum="653D4829CBE9EB78" modified="2021-09-29" version="1">MTDPFISTLFFLSRSFKSAFLSTTLFISFSQIFQISFSLFLSLFFSTNLSNQHISRFLFLTLSFFLSFFLSFFLPLSSGLSNQHLSLSHFLFLSFFLSFFLSFFLSFIPDLTNHHFSLYVSFSPQIFQIRISLSLSLSFSHSHHIFQISISFFLSFFLSFFLSFFLSFQIFEISISLSHTLSLFLSFFLSNQHFSLSLSLSLFLSFSLLRSFKSAFVKLLITLFHAAKIHASIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D9W2</accession>
    <name>A0A812D9W2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_51300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003106">
        <property type="protein sequence ID" value="CAE1296221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D9W2"/>
    <dbReference type="OrthoDB" id="5573326at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1296221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="221" mass="25850" checksum="2BF0E8D8E4FCAD28" modified="2021-09-29" version="1">MSFIHPSIHSSIYLSRIYSSIHLSIYLSIYSSIYLSIIHPSIHPSKSIIHRHYLSIHPSIYPSIHSSSIYSSNSFIYPSFHPSIYSNLLYLSIIQMYPSIHSSIYLSIYLSIYLSVKSVFSIIHPVQIYLFIHPSIYLSIYHINLFKCIHLFIHLSIQFFYLSFSSIHVIYQIIIHLSIYLSVHLNIYLFKSIHLYTNLFKIYHLSCSLLINSILSKNLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DBJ6</accession>
    <name>A0A812DBJ6_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-hydroxyisobutyrate dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SPHA_48831</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Farmed</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>3-hydroxy-2-methylpropanoate + NAD(+) = 2-methyl-3-oxopropanoate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17681"/>
            <dbReference type="ChEBI" id="CHEBI:11805"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57700"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-valine degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HIBADH-related family. 3-hydroxyisobutyrate dehydrogenase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.31" evidence="3"/>
    <dbReference type="EMBL" id="CAHIKZ030002749">
        <property type="protein sequence ID" value="CAE1291603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DBJ6"/>
    <dbReference type="OrthoDB" id="435038at2759"/>
    <dbReference type="UniPathway" id="UPA00362"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008442">
        <property type="term" value="F:3-hydroxyisobutyrate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000006">
        <property type="entry name" value="3-hydroxyisobutyrate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011548">
        <property type="entry name" value="HIBADH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="HIBADH-like_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01692">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22981:SF7">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22981">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0101">Branched-chain amino acid catabolism</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="8">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="9">
        <location>
            <begin position="81"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAE1291603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="217" mass="23000" checksum="D66D18CB97269668" modified="2021-09-29" version="1">MQKGTLLMDSSTIDPSVSQEIATKAEELGASFVDSPVSGGVNAAKDRLLTFMVGGKESAFAEAKVYLDMMGKNVIHCGAVGTGQAAKICNNMLLAISMIGTSEAMNLGIKLGLDAKMLAHILNVSSGRCWSSEIYNPVPGVKEGVPSSNDYKGGFGTALMTKDLGLAQNAAINTKSPTPLGSLCLHLYRIMCNTGFAEKDFSSAFKFLQEMENRNFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DC54</accession>
    <name>A0A812DC54_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">FBXL13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_53215</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003369">
        <property type="protein sequence ID" value="CAE1299406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DC54"/>
    <dbReference type="OrthoDB" id="6150766at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22977">
        <property type="entry name" value="DD_FBXL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1299406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="246" mass="29210" checksum="5645F55B9F342918" modified="2021-09-29" version="1">MAGLQLKSISPEMWEYIKDNQIAEICEALLTGLAVMCPQDPHKFIIDKLKYIKENGLECIQWDMFVEEHMRPKKRFMSNRGFDFLFGAEEEDKPTSEMFSKAYEYFNTQLKQKGLNALIENWIENKTHREQIIGKVVRIKKQREFKLMQTFFGGWRELTQQVVNRYSMAQQHLDHVSNVQLCAVVFTVWHHITQDSIRQREYFEIYLSIYLSIYLLGDWNKFVSHQCLSSVKGHGFKCLFSRSSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DC85</accession>
    <name>A0A812DC85_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">TUBG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SPHA_53559</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003421">
        <property type="protein sequence ID" value="CAE1300017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DC85"/>
    <dbReference type="OrthoDB" id="10249382at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02188">
        <property type="entry name" value="gamma_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000003">
        <property type="entry name" value="Tubulin gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002454">
        <property type="entry name" value="Gamma_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01164">
        <property type="entry name" value="GAMMATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="8">
        <location>
            <begin position="97"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAE1300017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="240" mass="27059" checksum="4E5C693D5CD2AAAD" modified="2021-09-29" version="1">MLEKLNDRFPKKLIQTYSVFPNLDEISDVVVQPYNSLLTLKRLTQNADCVVVLDNTALHRIACDRLHIENPTFAQINSLVSTVMSTSTATLRYPGYMNNDLVGLIASLIPTPRLHFLMTGYTPLTTDSQVASVRKTTVFDVMRRLLQPKNMMVSTPIHRQDKHCYISILNIIQGEVDPTQVHKSLQRIRERKLAQFISWGPASIQVALSRKSPYIPTAHRVSGLMLANHTSISSVSLLSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DCR1</accession>
    <name>A0A812DCR1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_53517</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003413">
        <property type="protein sequence ID" value="CAE1299924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="353"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="395"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="430"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="464"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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    <feature type="transmembrane region" description="Helical" evidence="1">
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    <feature type="transmembrane region" description="Helical" evidence="1">
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    <feature type="transmembrane region" description="Helical" evidence="1">
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        <location>
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        <location>
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        <location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="2503"/>
            <end position="2525"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1299924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="2655" mass="317998" checksum="E0CF5DD8D308D95F" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DD82</accession>
    <name>A0A812DD82_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PRPF4B</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_51939</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CAHIKZ030003185">
        <property type="protein sequence ID" value="CAE1297310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DD82"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1297310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="264" mass="30336" checksum="92FEBA4510B24559" modified="2021-09-29" version="1">MRLRRSAKSPSKRSGWSASVRCRRTPVIRLRRSVVSPSKRSGWAASVRCRRTPVIRLRRSAERPSKRSGWAASVRCRRTPVIRLRRSAERPSKRSGWAASVRCRRTPVIRLRRSVVSPSKRSGWAASVRCRRRPVIRLRRSAESPSKRSGWAASVRCRRTPVIRLRRSVVSPSKRSGWAASVRCRRRPVIRLRRSAESPSKRRSGWAASVRCRRTPVIRLRRSVVSPSKRSGWSASVPFLVCCQHCVICLSHVVKIVTAYNEYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DDH7</accession>
    <name>A0A812DDH7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_52042</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003205">
        <property type="protein sequence ID" value="CAE1297510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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        <location>
            <begin position="1651"/>
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    </feature>
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        <location>
            <begin position="1714"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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    </feature>
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        <location>
            <begin position="1957"/>
            <end position="1983"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="2003"/>
            <end position="2024"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1297510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="2025" mass="239306" checksum="E6BA6AD1DD5F3153" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DDL7</accession>
    <name>A0A812DDL7_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">T-complex protein 1 subunit theta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">CCT-theta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SPHA_53898</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003443">
        <property type="protein sequence ID" value="CAE1300526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DDL7"/>
    <dbReference type="OrthoDB" id="1748577at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03341">
        <property type="entry name" value="TCP1_theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000008">
        <property type="entry name" value="T-complex protein 1 subunit theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012721">
        <property type="entry name" value="Chap_CCT_theta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02346">
        <property type="entry name" value="chap_CCT_theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAE1300526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="543" mass="59388" checksum="32E402132D026354" modified="2021-09-29" version="1"> </sequence>
</entry>
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        <source>
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    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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        </submittedName>
    </protein>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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    </protein>
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    </comment>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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        <subcellularLocation>
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    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14978">
        <property type="entry name" value="7tmA_FMRFamide_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052954">
        <property type="entry name" value="GPCR-Ligand_Int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641:SF2">
        <property type="entry name" value="FMRFAMIDE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641">
        <property type="entry name" value="FMRFAMIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="224"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="21"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAE1307473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="337" mass="38107" checksum="02F02AEE029CC297" modified="2021-09-29" version="1">MAQYITGLIVYPITCIFGITGNILTLIVLSHKDLATSTNVYLSALAVGDTIKLINDTLYFIVLLIKTWNPLRGDESLARLYPYAHYLFNLSVCITGWLTVSVAFERYISICHPTRAKEMCTVYRARIVSTFVFVFMVVFSLPSALRYKTVLRRREITNATYLDVALTELGSNNAFMTPYTWIQNCVRTLLPLLILVFLNARIIHELRKSRVPGKKLSSRNRITLMLIIVVIVFIICVTPDAIMSTVFGFGYYDESNLVRGIREITDTLLAINSAFNFLLYCAMSKAFRDTFIKIFCGSCSGCDCRDGEACCPKEWVIGAHQTQKNIVGLVTKRNQFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DNS2</accession>
    <name>A0A812DNS2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_57871</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003920">
        <property type="protein sequence ID" value="CAE1305426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DNS2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="309"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1305426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="336" mass="40945" checksum="A927975675929CEF" modified="2021-09-29" version="1">MHSLQSFFPIPYSLSLSLSLSLSLSLSIILSLSLFLFLYLHLFVLHSVFSLFLSLFIFYTKVFVLFFFSFLFFISILFLELFFFHLLLNSLNFFTVLSLFFLVHPSISFFLSFFLSFFFFFLSFFSFFFFFFNFFFFLFFIAILFLQTFFFHLFLHSLNFFPVLSLFFMLVFPSISLFLSFFSLLLLFFYSYFFLEIFLFHLFLHSLNFFPFLSLFFMLVFPSISLFLSFFLCFFYFFIAIFSLKYFSFIFFFTLLISSLFSLCSSCWFSLPFLCFFIFFFASFIFFYSYFFFEIFLFHLFLHSLISSFSLFVLHVGFPFHFFVSFIFFFASFIFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DRB9</accession>
    <name>A0A812DRB9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_58884</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004056">
        <property type="protein sequence ID" value="CAE1306675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DRB9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1306675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="319" mass="38249" checksum="9D730D151E29F2DE" modified="2021-09-29" version="1">MCYIFILYCLQYLGLSLSTFYSSSFIYLYIHLFRYIVYHFFILSILQPFFFFSFFLDKDLICGLSSNGFLSFFLFSFLLAFPMKIKYMVQVLPHFLSFFILSLILSLFIYKDLIYGLSFTAFLILFSLSFFLSFLSYNYLTFGSSSNALLSFFLSFFLSFFLSFFFLIFLCFVFFKFFIIYFLVFLFLLSFFRFISFFHSLFSLFRRFFIKCLSFSILFLYSLLLCPLFSVFFRSLSFCFVTFFTFYIFLIPASLCISLHFSSFSLFSLYFLPYFPLNISIFFHLFPFCFLLLLPLIAISTSHSYSLSDNMFYFPFQSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DRV9</accession>
    <name>A0A812DRV9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_61224</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004310">
        <property type="protein sequence ID" value="CAE1309542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DRV9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="327"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="360"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1309542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="392" mass="45370" checksum="8759F4D3F60A9101" modified="2021-09-29" version="1">MYMCTCAHISLSLSLSLSLSLYNVSIYFCLHIIYLSIYLSIYFSLHIIYLSIYFILNLSVFCGFTSILLYSYLSIYLFGYLSIYLSIYLSVSVWLSTYLSIYLSIYLSICLSVSLVIYLSISAWLSIYLSIYLCLVIYLSIYLSIYLSEVCTPVCLSLSLSLPLLLPLPLSLPFLFLSMSFLFFFISLCHTCFELLFFFLFSFNFIKSFFFGIFSLPFFLSSFSHFIHFFFNYFSPLSFEIFSLSFFPSFIISLCIFLFCFPSSPPLSLSPFSSFVLSLFHSLSLSVFSALSQLSHSLSFLTHSLSLIISLFSLCSTYLFRFFTSFNYFYIFCISLHSSLILILYSFAFFFIFFPSLSPLSLFLFFLFITISVFVSLPLSLFHSIFSSPFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DS66</accession>
    <name>A0A812DS66_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_61411</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004340">
        <property type="protein sequence ID" value="CAE1309731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DS66"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1309731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="289" mass="34044" checksum="AE77FDA9EFE4E71C" modified="2021-09-29" version="1">MYYFFITYVGFSSFFYFHINKSLFVSFLSLLSSFLFPIHLCDLSFSYIVLCSSFSPIHFCVLPFPLSTSVFFLFPYTLLWSFFSPIHFCGLSFPLYTSVFFLFPYTLLWSFFSPIHFCGLFFFPIHFCGLSFPYTLLWSFFSPIHFCVLPFPLYTSVVFLFPYTLLWSFFSPIHFCGLSFPLYTSVVFLFSYISAFFLFTIYFYVPFFLSFPYTPLSSSFSLYTCILSFLYTLLHSFFLFPIYFFSYAPLCSSFLSFFSLCTLALFLSYFSFLPSFLSLCTPAHHIPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DUB6</accession>
    <name>A0A812DUB6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_62328</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004450">
        <property type="protein sequence ID" value="CAE1310807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DUB6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1310807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="159" mass="18609" checksum="67D204051D21E3AD" modified="2021-09-29" version="1">MLFCNSNALSYRALSEPIFSDSFFPFITYSLIPNLAIAFCLFLSISFFYCFLLTSVLILLLNIRFSFFISTPNSSFISYSSLIGFFTTFYANFQIFLSRFLIISFLISLFLHFLCFLLFFFSFCPFNVILFSFRRFLCLSFQILYVCSVRTKYSVGSIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DWU3</accession>
    <name>A0A812DWU3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_61814</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004391">
        <property type="protein sequence ID" value="CAE1310167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DWU3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1310167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="162" mass="19715" checksum="94958AF514BB092F" modified="2021-09-29" version="1">MKEIDSFRNDVTYFYGSLQRSVLFFFLRGKIFLACFFVVCFVCFHSNFLFLFLLFFSFFSLFLSIFVYCLLFLFFNFPFGFFAPVNFNVFFFFISFVPPAYRIFPFFIFDSFFFPSHFHSHFIFFFHHLNCISLFLFLYNFINFLIPPPLTIFHSPIVFLCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DZC9</accession>
    <name>A0A812DZC9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_61852</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004391">
        <property type="protein sequence ID" value="CAE1310281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DZC9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1310281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="154" mass="17626" checksum="F05677A8A52EAA6C" modified="2021-09-29" version="1">MPAASRLACVCPERWPNGSLIVPSKPMIYSNDGSPITSSAYPLCSVLTLGSRDETSRYPIRAKSHQFTSMPLLCISQSLNGREFVWALLGLCRALVYFSFLSISYFLLILYLLSFFPSFFLSFFLSFFLSFFPIFFSFFLSFKPYSFFLFFSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E155</accession>
    <name>A0A812E155_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_64010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004605">
        <property type="protein sequence ID" value="CAE1312828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E155"/>
    <dbReference type="OrthoDB" id="9981685at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1312828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="211" mass="24092" checksum="69BA9D7C0924FF43" modified="2021-09-29" version="1">MEYERRAVVVASFRVGKKPAEVMAWTDEFVTAVKKTVENDGSQSYAKITADMGCHKSTICRTIKKDIDYSSYRKSHCMLITNASKESRKVKAVALLNELEHGSAGMLRFFSHEKNFIQDKTSNRQNGRWMFPSIMVLGIISRPESTAEIYQEVPRRVVKPSIDEIVAGRPYVFQQDSAPAHKAKTTQAWLLNNVLHHWSPDLWTPDFNLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E2C4</accession>
    <name>A0A812E2C4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">FANCM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SPHA_64356</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Farmed</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DEAD box helicase family. DEAH subfamily. FANCM sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004631">
        <property type="protein sequence ID" value="CAE1313197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E2C4"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045003">
        <property type="term" value="P:double-strand break repair via synthesis-dependent strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12091">
        <property type="entry name" value="FANCM_ID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18801">
        <property type="entry name" value="SF2_C_FANCM_Hef"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1320.20">
        <property type="entry name" value="hef helicase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039686">
        <property type="entry name" value="FANCM/Mph1-like_ID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14025">
        <property type="entry name" value="FANCONI ANEMIA GROUP M FANCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14025:SF20">
        <property type="entry name" value="FANCONI ANEMIA GROUP M PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="314"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="531"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="645"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="716"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="546"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="645"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="723"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAE1313197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1037" mass="116787" checksum="CA73DB7E97DE6CEA" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E433</accession>
    <name>A0A812E433_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Helitron helicase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_67370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004884">
        <property type="protein sequence ID" value="CAE1316728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E433"/>
    <dbReference type="OrthoDB" id="6151730at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786:SF74">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786">
        <property type="entry name" value="DNA BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="469"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Helitron helicase-like" evidence="2">
        <location>
            <begin position="125"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1316728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="505" mass="58006" checksum="49E8907A7DB7ECEE" modified="2021-09-29" version="1">MGSLQFLQIYFLADYNEQVEARLGILPSDISVGPRRDILFRLQDMLYETNSYIRSLKFALQNNPSPSFSVVIDADRRPHGEHERRFNAPACNEVAAVIHGVEHNSRDIANSGSMSTSKTVSCRAYYANMFMVREGEFNHVHRCRQLFLQFAVDMAAKMESERLGSIKLNQSKLRTDSYIHLRDGLRSDGDPRNLGKSCILPSSYTGDPRYMHERTQDAMTYVRHYGRPDLFVTFTCNPKWVEITRELFPGQQYSHRPDLIARVFRLQLCKLMDLIIKGQVFGRVKCHMYTVGWQKQGLPHAHILLWLNDKVDANKINDYIPAEIPEPALHPLLHEIIKNNMIHGPCGANYEKRSCWSSGPTCAKGYPRKFISETQTATNGYPLYRYTSPAEGGRTVTVKGHILDNRWVVPYCSLLSKTFGAHINVEYCHSVKSIKYICKYINKGSDAAVFGIRRDNCVDEVAEYVAGRYLSIFFLFFFLSFFLSFFLSFFLSFLLARSTSYDHFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E482</accession>
    <name>A0A812E482_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">SAFB-like transcription modulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SPHA_66866</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004831">
        <property type="protein sequence ID" value="CAE1316075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E482"/>
    <dbReference type="OrthoDB" id="79455at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12417">
        <property type="entry name" value="RRM_SAFB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051738">
        <property type="entry name" value="SAF_Modulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15683:SF8">
        <property type="entry name" value="SCAFFOLD ATTACHMENT FACTOR B, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15683">
        <property type="entry name" value="SCAFFOLD ATTACHMENT FACTOR B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="SAP" evidence="7">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="282"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="13"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="196"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="356"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="653"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="795"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="509"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="13"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="124"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="196"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="225"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="260"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="374"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="471"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="485"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="653"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="795"/>
            <end position="807"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAE1316075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="865" mass="96495" checksum="4D6D864C293B4F4E" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E5E9</accession>
    <name>A0A812E5E9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_66942</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004832">
        <property type="protein sequence ID" value="CAE1316144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E5E9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1316144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="258" mass="29935" checksum="6D5CD87D0DB53C84" modified="2021-09-29" version="1">MTPLRGDGFVFFLSLLCCFPILSFFLSFFLSFFYSFFLSFVYLFVPIWFFFLSFFLSFFLSFFYSFFLSFFLVTGLSFFVISHTIMSRHCYIYLSIYLSIYLSIYLSIYLSQSVHYLSIAVCSLSIYLSIYCGSVHYLSIYLSIYLCLIIYLPLSPYNLSSVRIYLSIYLSIYLSIKINRHHCYKQASPPCREYRHLGNANTLQRPNIQPGHIMLKIPILTIDNISTSTLPPPQLQVFHGTNAVTSANPSHYSDSASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E7P1</accession>
    <name>A0A812E7P1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_66321</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004782">
        <property type="protein sequence ID" value="CAE1315347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E7P1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="224"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1315347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="244" mass="28580" checksum="8A7D99F1ECA6248E" modified="2021-09-29" version="1">MLCSVIWNRNHCCLILSLVCVFSNTIRYILLLFHHHHHHHHHLLLLLLLLLLLLLLLLLLLCNSSSSSSSSSSSSSSTTTTTTTTTTTTTTTTSSSLLFLLLSPFIFLLIFSFTSPLPSSFPPLPSFYSFSPSPPFPFHFSPPSSHLIRVYVLHFLLLLLFSFLFLFLPSISSLFYCHFLFVLYFHLVSLFIQFFFQSFYFPFFFFFFFLLQVTFYHLHSFPDIVHFSFFFIFTIYLMPFFPRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E897</accession>
    <name>A0A812E897_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_67637</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004896">
        <property type="protein sequence ID" value="CAE1316845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E897"/>
    <dbReference type="OrthoDB" id="10565432at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="317"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1316845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="368" mass="41804" checksum="AC5A15DFA57BD5AE" modified="2021-09-29" version="1">MSSRKLVLDKRLLTPQKLTRAFRFSNFLATHTYSTEHRIFLRFSTTVLSHSLFYASARLHFKSSVKFHFQRAKENTTLLTTMDQNQILRSFLFFVAFQDLFGIGLVQYIEDVCFWRSQLQLVDCDDTAITSVKFQSRHEGYTELSLKGTHLQNLSFNVSFLPDLKVVDARNTSLSCRKIALSILEVIDHVIVDVKSCFNAICCWKFRVSNESITDNRDSNKYIKRRPNTAWSRSPEIPTPQARHQPVSDMMLSKNDAQASSNSVVHQNVGVNLVKNQVPNAISVSTQVKINCGDTMTKKQPEKQTVSESSFGADMTIVYSVVGICSVTSLVSLSLSIYTMCTLYRQRNCSLKDFSMPLRSRSQGTVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E9M1</accession>
    <name>A0A812E9M1_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein L15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SPHA_69704</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Farmed</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005099">
        <property type="protein sequence ID" value="CAE1319278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E9M1"/>
    <dbReference type="OrthoDB" id="10255148at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1120.10:FF:000001">
        <property type="entry name" value="Ribosomal protein L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1120.10">
        <property type="entry name" value="Ribosomal protein l15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024794">
        <property type="entry name" value="Rbsml_eL15_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000439">
        <property type="entry name" value="Ribosomal_eL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020925">
        <property type="entry name" value="Ribosomal_eL15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003269">
        <property type="entry name" value="PRK04243.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11847:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11847">
        <property type="entry name" value="RIBOSOMAL PROTEIN L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00827">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01384">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01194">
        <property type="entry name" value="RIBOSOMAL_L15E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="62"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="62"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="84"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="151"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAE1319278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="464" mass="54233" checksum="7EBB65D7840D0B76" modified="2021-09-29" version="1">MFLNTLKQQQRDSNNSLLEKKPNSKEKPLSIQQKKRKFKSGHLHRLEHVVLGNEDFVIESLKHKELDNKEDKKVEDSSAKSVESDEEESDDEEPERKKPVWNDDDDDGEYDNKIYAVRQTSQFASETPKWAQLNCGKNIKKRNRKKPRFLDDDDDDDDDEDEIGLSHSTGNYLTSSSTLTSINLQIKKCSDLNKEYASNDLSALEFHRKSTVALTAGSDFRFHLFQIDGEHNRKIHSVVLERFAISFFLVECPYWTEVSKMGGYKFMQEIYRKKQSDVMRFLLRIRCWQYRQLNVLHRAPRPSRPDKARRLGYKAKQGYIVYRIRIRRGGRKRPVPKGATYGKPKTHGVNQLKFARSLRAVAEDKVGRRCKSLRVLNSYWVAEDSTFKFFEVILVDPFHKAIRRDPKINWICNPVHKHREMRGLTAAGRSSRGLGKGHGYHKTIGGSRHASWKRRQILSLRRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EA68</accession>
    <name>A0A812EA68_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_68909</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005032">
        <property type="protein sequence ID" value="CAE1318453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EA68"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1318453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="215" mass="26324" checksum="8F5774A5A4F532F4" modified="2021-09-29" version="1">MWRYRCDQEIPVFRETVELSQVELFNVACVRSRSVVSNQLTVVFRSSHFLFLSCIFFFQYFLLFSFLLSFSFLLSFFLFFVLFSFLLSFFFSSFFFSFFFLFLFFLSAFFFVFFVLFCFLLSFLFSFFFLFFILFSFLRSFFVSSFFFLFFILFSFLRSFFFSSFFFLFFFLFCFLLSFFFSSFFFLFFVLFFPLPSASLILFFLASPSSTLWPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EAA0</accession>
    <name>A0A812EAA0_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Receptor ligand binding region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SPHA_71331</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005219">
        <property type="protein sequence ID" value="CAE1321222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EAA0"/>
    <dbReference type="OrthoDB" id="1890790at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017046">
        <property type="term" value="F:peptide hormone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052612">
        <property type="entry name" value="ANP_Clearance_Receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44755:SF11">
        <property type="entry name" value="ATRIAL NATRIURETIC PEPTIDE RECEPTOR 3 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44755">
        <property type="entry name" value="NATRIURETIC PEPTIDE RECEPTOR 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Receptor ligand binding region" evidence="6">
        <location>
            <begin position="83"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAE1321222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="317" mass="35675" checksum="1912E803B9DA57EC" modified="2021-09-29" version="1">MILKKKVIILFRSFFVSVFDNRSTCLFISRPQNASFLFIHFTFLSIRSIRALSSYLPIVCSYLSIYLSIYLSIYLSIYQFIFLMSQVEIVAHFQDSACSSRVAPIAAFEAYRQKKVNVFFGPVSDYSLAPVARYASYLNIPIVTPGGMVFDFAAKTSPTAEYKTLSRVGATSVRLAEHMMSILKDNNWKELKMIVDAECQQEVMPKLCFLLSSGVVYWFRRAGIKPVEHVWKTGMETPDYILTEIIGVQHSVCPYLSIYLSIYLSISSPTNSPLLPARANELLGNRTGLNSALRAKRTLLCPPGSIELLALISHRPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EAD5</accession>
    <name>A0A812EAD5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_67567</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004896">
        <property type="protein sequence ID" value="CAE1316930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EAD5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="337"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="417"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="448"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1316930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="467" mass="55563" checksum="DE87324D1CB8EDDC" modified="2021-09-29" version="1">MPDVITKSIYNCEKSVLHETARMNIPRKSLAVAGETFRFTHPCHPIEQQPIAAARLNFVDAQGFRNGTDVKKIILQPKECFYFENLFLLFSVFLLFFFPLFLLILFLSLFSLILPRAPSLSHFFFLPFFCIFFLSFFDFLSFVLIFFLRIYFLPFFFFLFFFFRFFFLSFLFISLFFFHLISLSLSLSLSLSLSLSLSLSLSLFFKRPNSIIISKNNRPRFTARVNFVGLGSGLPETGVANRDTLFLFSLSLSLSLSLSLSHSFLHSFCLIIDFLLSFTRSLSPLLPFFHLSYFLFISFFLYLSFFKIMSFFFDHFFSVFIRFSLFSRLFLSFTKSLSSLLFSFLLLFLFFLIAYLIFCNFTSFYNFFLFHSFLQFLSLFFLSFFSFTLSFIFISLFSFSLSFSFIHFFLSSFLSFFFVHFYSFLLSFYISFFLRFSFFLLFFLSFQFYSFFLSCFVSLFFFFVLIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EAH5</accession>
    <name>A0A812EAH5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_70071</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005121">
        <property type="protein sequence ID" value="CAE1319742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EAH5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1319742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="231" mass="27548" checksum="3284E3AA9A843BA0" modified="2021-09-29" version="1">MVLSFFLSALINCNLLSLSLSLSLSNTLSFFFFASCFLFFLLLSFIFSFSFWVFYFLIFLFLSFFLSYFSSFFERSSTFFLCLYVFLFSFFLSLLLVSPLSFFLSFFHQLLFFVYTSSSLFLTFLLSFFLCLSFSSFLCSLFFFEPFLSTFFIFLLVLLRLSFFLSFFLSHSIYHFYSSSFFSNLLQLSFFPYTSFFLQHSFFVHTSSSFFLPFFLFLALIFPCSCFLFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EDV7</accession>
    <name>A0A812EDV7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_71727</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005255">
        <property type="protein sequence ID" value="CAE1321679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="299"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="332"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="360"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="468"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="493"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="520"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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</entry>
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</entry>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="325"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1331975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="373" mass="43927" checksum="3D79CDEE68DCA9B9" modified="2021-09-29" version="1">MLSDVKLPRNISTADKVVIFDNLNVRLGRDLKLENQTKVKVNISIYLSIYLSIYLSIYLSIYRINCSLFIYLSYHVLSVSIYLSIYLSIYLSIVSSVYLSIYRIICYLFYLSIYLSTLSSIYLSIVSSVYLSIYRIICSLSFYLSCHIYLSIYLSIYLSIYRIICLSIYLSIYLSIYLSIYLSCHLYLSIYLSIYRIIYLSIYLSIYLSIYLVICIYLSIYLSIVSSVSIYLSIYLSIYLSIYLVICIYLSIYLSIYLSIYRIIYLSIYLSILSSVSIYLSIYLSVIQPLLRGNVRISLFYFYTSFIYLSIYLSIYLSIYLSQSIHYLSIYLSIYLSLFIIYLSQCIHYISKSVHYLSIYQSLHYLSMLPSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ERY3</accession>
    <name>A0A812ERY3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_81243</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005628">
        <property type="protein sequence ID" value="CAE1332168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ERY3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1332168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="203" mass="24263" checksum="BCAEB5DA710040A0" modified="2021-09-29" version="1">MPYSSHFRDIYSYPVCFHGGGRFFSFASTRKLYYFYSTLFYSILIYLSIYLSIYLSLFPSIYLSIYLSIYLSISVYSHLSIYLSIYLSIYLSIYLSMSVCFFYLSIYLSIYLSIYLSIYLSQFFPSIYLSIYLPSYLSTYLASYLFVPIYLSIYLSIYLHTYLPIYLFVPIYLSIYLSIYLSIYPFPYLTVFHSTFFHIIILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ESL0</accession>
    <name>A0A812ESL0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_81296</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005630">
        <property type="protein sequence ID" value="CAE1332244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ESL0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="324"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="385"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1332244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="415" mass="47940" checksum="CE7AFF67F388829D" modified="2021-09-29" version="1">MHVFIIGLYYKIYLSIYLSIYLSIYLSIYLSIYLSIYLSIYLSIYLSLSLSILVSLYPCLSLSLSLSILVSLYPCLSLSLSLSITVHSFWNITVITFVLTDILFLHSLSFLTFFLFFSLHFFSFSSFFLSFFLLFLSSPSVFSFVLLSLLFSSLSLSFSLNVSRFSLSLLVSLCLIFSPLLFNFLSPFNCLCLPPFNCLCLPPFNFLCLPPFNFLCLPPFNFLSLSLPPFNFLYLSLPPFNFLYLSLPPFNFLYFSLPPFNFLYFSLPPFNFLYFSLPPFNFLYFSLPPFNFLYLSLPSFTSCSLFISLSLHLLLALYLSLSPFIYFLLSIYLSLPSFTSCSLFISLSLHLLRALYLSLSPFIYFVLSIYLSLPSFTSCSLFISLSLHLIFLSYLHFSLLVYLYLPLFSYIYSII</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ETS3</accession>
    <name>A0A812ETS3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">E1.1.1.30</fullName>
            <ecNumber evidence="3">1.1.1.30</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_79284</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.30" evidence="3"/>
    <dbReference type="EMBL" id="CAHIKZ030005564">
        <property type="protein sequence ID" value="CAE1329928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ETS3"/>
    <dbReference type="OrthoDB" id="5296at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003858">
        <property type="term" value="F:3-hydroxybutyrate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313:SF36">
        <property type="entry name" value="D-BETA-HYDROXYBUTYRATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY 9C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032856818" evidence="2">
        <location>
            <begin position="21"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1329928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="290" mass="32002" checksum="C23E5523D9B94A33" modified="2021-09-29" version="1">MLPTKLFLILLSCVVLGAVAKLQPEDSKNYIFGQNALLIIALAIPFCLCLLQSKEFVKADNKAVVITGCDSGFGHSLAIRLHKLGYTVYACCLFSQQEGAKGLRKIGGSRMHVLQVDVTSEAQIREATEYVKSTLGNTELWALVNNAGIASYAEIEWCAVNVFQRIMDVNVIGVVRMTKSFLPLLRTTKGRVINVASLSGRYTLPAFAAYSMSKVACIAFSDGLRQEMSKFGIKVITVEPGLYRTPIAVQMMAESKKRWDDTPTEIKDAYGEEYFAEIFSCSMHRPYPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AL32</accession>
    <name>A0A812AL32_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="5">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="31" type="ORF">SPHA_117</name>
    </gene>
    <organism evidence="31 32">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="31" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="31">Farmed</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="31">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="5"/>
    <dbReference type="EMBL" id="CAHIKZ030000001">
        <property type="protein sequence ID" value="CAE1137458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2156623at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072518">
        <property type="term" value="F:Rho-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031032">
        <property type="term" value="P:actomyosin structure organization"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030866">
        <property type="term" value="P:cortical actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0048598">
        <property type="term" value="P:embryonic morphogenesis"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901888">
        <property type="term" value="P:regulation of cell junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd20813">
        <property type="entry name" value="C1_ROCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01242">
        <property type="entry name" value="PH_ROCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22250">
        <property type="entry name" value="ROCK_SBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000017">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000308">
        <property type="entry name" value="Rho-associated protein kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001229">
        <property type="entry name" value="Rho-associated protein kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.730">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057529">
        <property type="entry name" value="MRCK/ROCK_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050839">
        <property type="entry name" value="Rho-assoc_Ser/Thr_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015008">
        <property type="entry name" value="ROCK_Rho-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988">
        <property type="entry name" value="MYOTONIC DYSTROPHY S/T KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988:SF73">
        <property type="entry name" value="RHO-ASSOCIATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25346">
        <property type="entry name" value="PH_MRCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08912">
        <property type="entry name" value="Rho_Binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103652">
        <property type="entry name" value="G protein-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51859">
        <property type="entry name" value="RHO_BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16 22" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="18 21 23" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="20" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="14" id="KW-0418">Kinase</keyword>
    <keyword evidence="17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="19 25" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 22" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="32" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="10 31" id="KW-0808">Transferase</keyword>
    <keyword evidence="25" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="25" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="15" id="KW-0862">Zinc</keyword>
    <keyword evidence="13" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="123"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="165"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="237"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="456"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="479"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="509"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="541"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="568"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="601"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="644"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="677"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="27">
        <location>
            <begin position="303"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="29">
        <location>
            <begin position="820"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="domain" description="RhoBD" evidence="30">
        <location>
            <begin position="1425"/>
            <end position="1491"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="26">
        <location>
            <begin position="1600"/>
            <end position="1798"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="28">
        <location>
            <begin position="1710"/>
            <end position="1765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="889"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1579"/>
            <end position="1598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1804"/>
            <end position="1843"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="23">
        <location>
            <begin position="914"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="23">
        <location>
            <begin position="1179"/>
            <end position="1481"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="23">
        <location>
            <begin position="1506"/>
            <end position="1579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="889"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="901"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="PROSITE" id="PS51859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="EMBL" id="CAE1137458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1843" mass="216402" checksum="C3C20C186F2AEDC0" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ALA4</accession>
    <name>A0A812ALA4_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ribosomal protein S6 kinase</fullName>
            <ecNumber evidence="12">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">SPHA_976</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">Farmed</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="12"/>
    <dbReference type="EMBL" id="CAHIKZ030000027">
        <property type="protein sequence ID" value="CAE1142002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ALA4"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14091">
        <property type="entry name" value="STKc_RSK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05582">
        <property type="entry name" value="STKc_RSK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000010">
        <property type="entry name" value="Ribosomal protein S6 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000041">
        <property type="entry name" value="Ribosomal protein S6 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000013">
        <property type="entry name" value="Ribosomal protein S6 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000121">
        <property type="entry name" value="Ribosomal protein S6 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016239">
        <property type="entry name" value="Ribosomal_S6_kinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041906">
        <property type="entry name" value="RSK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000606">
        <property type="entry name" value="Ribsml_S6_kin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 12 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5 12 19" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="58"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="18">
        <location>
            <begin position="318"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="418"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="737"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="535"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="64"/>
            <end position="72"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14 15">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="424"/>
            <end position="432"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14 15">
        <location>
            <position position="447"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR000606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000606-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000606-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CAE1142002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="757" mass="85022" checksum="F865642111694A26" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AQC9</accession>
    <name>A0A812AQC9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_2026</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000058">
        <property type="protein sequence ID" value="CAE1147103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AQC9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1147103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="196" mass="23151" checksum="F7848F85678615B3" modified="2021-09-29" version="1">MLLSTSSSSNHSVSLFISIYLSIYLSILFPLLPIYLSIYLSIYLKIFLSIYLSIYLSIYLSIYLSVSVYSYLSLFISFYLSIYEIYLCSYLSIYLSIYLSIYLSRPVLIYLVLFLSIYLSIYLSQSSVHIYLSIYLSIYLSIYLSLFISIYLSQSIHIYLSIYLSIYLSIYLKVRIYPFIIYFFSLFKGEYSERIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AQT1</accession>
    <name>A0A812AQT1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">N4BP2</fullName>
            <ecNumber evidence="3">3.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_3814</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.-.-.-" evidence="3"/>
    <dbReference type="EMBL" id="CAHIKZ030000114">
        <property type="protein sequence ID" value="CAE1153329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AQT1"/>
    <dbReference type="OrthoDB" id="6161836at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14279">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052772">
        <property type="entry name" value="Endo/PolyKinase_Domain-Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009818">
        <property type="entry name" value="PAM2_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46535">
        <property type="entry name" value="NEDD4-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46535:SF1">
        <property type="entry name" value="NEDD4-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13671">
        <property type="entry name" value="AAA_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07145">
        <property type="entry name" value="PAM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00463">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SMR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Smr" evidence="2">
        <location>
            <begin position="650"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="443"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="301"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="450"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1153329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="728" mass="83478" checksum="878CB61529CEE667" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ARU0</accession>
    <name>A0A812ARU0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_4320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000136">
        <property type="protein sequence ID" value="CAE1154857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ARU0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1154857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="204" mass="23599" checksum="637ECFB6489801C9" modified="2021-09-29" version="1">MIVRRVGGNCIIRGIILLLICTCQKKKKDELNFYLSIYLSIYLSIQANSHVVIDQDSLISLRLHCPIFIHFSFSSLSNIHSFHFVCIVQHSFISFRLHCPAFTHFSSSSLSCNHLFLFVFMIQTSFMPLRLHCPAFTHFSSSLPINHSFLFLFIVQHSLIFHRIQSSISSFHHPAFSFFFSSSLSSIHFFIIVFVVQDSIIYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ASK4</accession>
    <name>A0A812ASK4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_3102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000091">
        <property type="protein sequence ID" value="CAE1151333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ASK4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1151333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="215" mass="26170" checksum="DE863F91BA3007B9" modified="2021-09-29" version="1">MFLFSFFLFFLSFFLSFFLRLFLSFVKFASFFLSFFLSFFFPFRPHQLFLSVVKFLHFMIFSFSFFLFFLSFLSFSSPTNSFFLSSSPFLSIFFFLLFLSFFLSVPTPIFLFVKFSFLSFFLSFFLSFFLSFFLSSFTDVSFFLSFFSFFLSFFFLFFSSSPLMFFQFFFFSFCFKIPSPTNCFFVPCSFFLSFFFFSFLSFFFLRPHTNCFFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ATI0</accession>
    <name>A0A812ATI0_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SPHA_4364</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000138">
        <property type="protein sequence ID" value="CAE1155051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ATI0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039715">
        <property type="entry name" value="ZCCHC10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13491">
        <property type="entry name" value="ZCCHC10 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13491:SF0">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="205"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="239"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="274"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="314"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="348"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="380"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="408"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="442"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="466"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="491"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="524"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="616"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="26"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAE1155051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="647" mass="75011" checksum="AFBF74658EE0B065" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AX81</accession>
    <name>A0A812AX81_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_6743</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000220">
        <property type="protein sequence ID" value="CAE1161162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AX81"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1161162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="212" mass="24801" checksum="B2B0374AB44C3129" modified="2021-09-29" version="1">MFLSFISYFSFFLSFFLSFFLSFLFPIARNRNVTPTPTQIMCKQHFVFGFIYLSIYLSIYLSIYLSIYLSQRTHKHMDNIHMLSISVYTSPSFIISLFSPFFRSFLFLIFFSVLPSFLPSFLPLLLFLTFLPFLPSLLPLLPSFASFLPSFLPSFLVFTLSISKILHIMHLPSFLFLSLHNIFLYPASYLCSIAKSRHSIYLSIYLSIYLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AXT7</accession>
    <name>A0A812AXT7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_7494</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000240">
        <property type="protein sequence ID" value="CAE1162982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AXT7"/>
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        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
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        <location>
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        <location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        </location>
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        <location>
            <begin position="334"/>
            <end position="359"/>
        </location>
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        <location>
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            <end position="388"/>
        </location>
    </feature>
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        <location>
            <begin position="394"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="432"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="458"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="496"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1162982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="516" mass="60612" checksum="AE7E4334B7F13C0E" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AXZ0</accession>
    <name>A0A812AXZ0_ACAPH</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_7339</name>
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        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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            <taxon>Coleoidea</taxon>
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            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000236">
        <property type="protein sequence ID" value="CAE1162525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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            <end position="50"/>
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        <location>
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            <end position="85"/>
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        <location>
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            <end position="173"/>
        </location>
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        <location>
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            <end position="207"/>
        </location>
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            <end position="234"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1162525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="308" mass="36678" checksum="24E0C099B37D84DB" modified="2021-09-29" version="1">MFSIGRPEKGRWTRVKADFFSHSFFDFFLSFLCSSLFVSLFLFDLIFFLFHSHLLSLISLCFNFILFIFVFILHSFLSFFLRFLYSFLLFFFRLKPLPFLPFFFLSLFSFSILSFFLALIPSLLDSFFLSLLSPPFLIEIISRIRFSFLYKMKTFLSFFLSFFLSFFLSIPFLPYKLKAFFIHSLIRSFFLFFKLDFFSLFFVLILLNRAHSRFLSLSLSLSLFLAFSLSLSLSLSLSRFLSFSLSLSLFLSFSLSLSRFHIHTSCLSFIARRPLCRSDSVQFLLLYFFLFFRPNRQMSCPKDKNLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">SPHA_7330</name>
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    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
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            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
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                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000236">
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            <begin position="249"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAE1162384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="273" mass="33814" checksum="DF276BE6D05F2190" modified="2021-09-29" version="1">MHQHNTFHYFYSFVFILPFNLHFNFLFIPFRTTFHPFFIYLFILSQFPFHSFSLPFHSIFHSMLYSPFHYFSFCFQFFHYFSFSLLFFMILLSILFHSICFLFLILTLFLFHSKFRSFSYYIAYLFILPSILFRSSCHSFSFFKFSLSFVFIPPFFLFHSTFDSFSFFLAFIFILLIPPLINFHYTFLYFSFYFRFIFILPAVHFHSFNSPFIRFHFSFLSFSFYLSFFTILLVIHFHSLKFPSHSFSFYFILRFILFFFPLFIQSQIFIFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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    <name>A0A812B102_ACAPH</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_7931</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
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        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="CAE1164232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B102"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="70"/>
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        </location>
    </feature>
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        <location>
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    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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    </feature>
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        <location>
            <begin position="298"/>
            <end position="319"/>
        </location>
    </feature>
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        <location>
            <begin position="331"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="458"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
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        <source>
            <dbReference type="EMBL" id="CAE1164232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="529" mass="62065" checksum="EA2974F3BBC64B3E" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B1L6</accession>
    <name>A0A812B1L6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <organism evidence="2 3">
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        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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            <taxon>Coleoidea</taxon>
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            <authorList>
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                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000365">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1170523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="263" mass="30658" checksum="880BD2FA22ED9013" modified="2021-09-29" version="1">MFLFPPFFFLFESLFLSLSISFYLTIFLSIYLYSLSLSLFHSFLRSAAFLLSLFLYHNLSFYLFIRSLSLSLSLSLSIPFCFFYCSSLFCSLFCSFFFLAQVSISYVYVSVYFKPSRLSVPDSTTITLSPLALYLNITPFSVIGQFLLPLFLFFPFSFFLLSFLCLSNFFYLSIYLSIYLSIYLSIYLSVLFCLSLYLSIYLSIYLSIYLSICLSVCLSICLILFISIYLSIYLSIYLSIYVDICDWLSNMYLFLVRSHSVDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B392</accession>
    <name>A0A812B392_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_9192</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000294">
        <property type="protein sequence ID" value="CAE1167084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B392"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="379"/>
            <end position="399"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="419"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="454"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1167084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="481" mass="57826" checksum="52A20F025122238B" modified="2021-09-29" version="1">MISKRLISHKNKSIQLSFFLAFFSIFLSFQSFFLSFFQIYSFFLSNLFFLSLKSFLSFFQIYSFFFLSFQSFFLSFKSILSFFSIILSFFLSFFLSNLFFLSFKSILSFFLSFFLSNLFFLSFKSILSFFLSFQLFFLSFFLSFFQIYSFFLSNLFFLSFKSILSFFLSFQSFFLSFFLSFFQIYSFFLSNLFFLSFFLSFQSFFLSFFLSNLFFLSFKSILSFFLFSFFFLFFSFFLSFRFLTIFAFLIFDHIYFILLSIYLSIYLSIYLSIYLSESADIYLIALSLSLFIYLSLSHHIYDSVIYLPLYLSIYLSIYLSSSLSIYIYIYIYIYIYYSPSLSLSINPCMIQRYIYDSVIYLSIYLSIYLSIYQSESADIYLIALSLSLFIYLSLSHHIYDSAIYLSSHDIYLIPLSIYLSIYLSIYLSIYLSVILSLSIIYLSIYLSIYLYIYIYIYIYILFPLSLYLSFYLFIYGPTIYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B3W5</accession>
    <name>A0A812B3W5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_9370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000301">
        <property type="protein sequence ID" value="CAE1167366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B3W5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1167366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="267" mass="32006" checksum="983A8F16DB9FAC3A" modified="2021-09-29" version="1">MKKHFTVNPFFLTCFFYCRHFVFSAFFIFFLFQFSSFSHFVLHCFSSLILIFSSLFLSFFLTQFNISYLHFPSILLFLFSFLPLLFCISSFFLSFFSFCFIFSSSLFCVFSTIFISFSHVSLKFLIFAVYFSYSFFLHLIFVCLLSFTFSFFFFFFKCTIYFSSLFFSYHLHLSLLSFFFICFFFSMSSLLISLFSSLPVFFIIIYKVWYFFLLHSLLFLSVCDSTIVFFFFIFLSDVDVVVLIFVLSLVPLLLLHFRLMVLMNRMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B4W3</accession>
    <name>A0A812B4W3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_11109</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
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        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
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            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000365">
        <property type="protein sequence ID" value="CAE1170441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B4W3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="33"/>
            <end position="52"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1170441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="257" mass="30778" checksum="EDFF59A5F393D994" modified="2021-09-29" version="1">MGMRQQFLHLSGFSCFTADKQRVFPLLTGTRRIAFTFVIIYLSIYLSIYLSIYLSKFIIYRCFLIIYLSIYLSIYLSIYLSIYLHYKCLYLYIYFTSFFLPLFSLSLSIYLSIYLSISVHYLSMLLNYLSIYLFHFHLSIYLSISVHLSLSIYLSIYLSIYLSIFLSIYLYQFIIYRCLLLIYLSIYLSIYLSIYLSIYLCRFIIYLSIYLSIYLSIYLSIYLCSMYVYVCIYISISFHSLSRSLSLSMSVHYLLML</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B5E2</accession>
    <name>A0A812B5E2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_10167</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
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            <taxon>Coleoidea</taxon>
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            <taxon>Sepiida</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000328">
        <property type="protein sequence ID" value="CAE1168681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="21"/>
            <end position="42"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1168681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="266" mass="31602" checksum="9FCE70759EC176E1" modified="2021-09-29" version="1">MIIYFRIIYTYDRFKFTFKSIYLFQSVHIYHLSIYLSIYLSIYLNLFISIYLFICFSMFIYVCQSVHIYLFQSSYLSIYLSIYLYQSVHIYLSIYLSIYLSISACPYLSKSSLSSLFLSTYSFFFLFTLLLPPASFYRILYFCFQYTLLCSLLPPVFSNTPLLFDLSFFLSSPFTSDNYICHVFSITCPLIVPSFSSFSSFILYCITSISMSVTLYYFCLPLLKLIFTRHVIHSDLQIIYIFLNLYIYLSIYLSIYLSIYLSIYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B688</accession>
    <name>A0A812B688_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_13691</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
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            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000459">
        <property type="protein sequence ID" value="CAE1175546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B688"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="266"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1175546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="293" mass="35450" checksum="6D6A837B57AD9D27" modified="2021-09-29" version="1">MEKNSTSFFFHILFFSYSISFFFSYLFSLFFSYSFFLSFFLVLFLSFFLVLFLSFFLIVLFFFSVSISPFLFSFRVDISLSFFFPCRYLSFFFLSVSISLFLFFFPCRYLSFFFSFRVDISFFFSFRVNISLSFFLSVSISLFLFFFPCQYLSFFFSFRVNISLSFFLSVSISLFLFFLFRVNISLFFFFFRVNISLSFFFPCQYLSFFFSFRVNISLSFFSFRVNISFFLSVSISLFLFSFCVVLFFTYSLFIVFSPFLSYTGPFLFPLILFSPSLFDYFFLFFSFLLQLHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B6S9</accession>
    <name>A0A812B6S9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_11276</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000372">
        <property type="protein sequence ID" value="CAE1170789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B6S9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="282"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="312"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="401"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1170789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="473" mass="56345" checksum="808A5AC34CE500D4" modified="2021-09-29" version="1">MIESYQFGFEGLFSPCWSCFSLSLSFSLSLFLSLSLSLFLSRSLSIYLYIYILCLFISIYLSIYLSIYLSLSVYVSIYLSIYLSMSVFLSMSVYLSIYLSMSIYLSIYLCLIFICLSIYLSIYLSIYLSIYHCLFIYLSIYLSMSIYLSMSVFYLSIYLSIYVCFSIYLSLFMYLSISLSIYLCLFFIYLSIYLSIYVCLSIYVCLYIYLSMSIYLCLFFIYLSIYLSIYVYLSIYVCFLSIYLSIYLCLSIYLCLFFICLSIYLYICLFIYLSIYMLNTYIFFLFFNYLINSFLLSFFFFLSFILSFFLSFFLHVSVFISFSTLVSFFLSFFLLSFFLSFSKLVSLFLFHASFFSFFLSFFSFFLFFLSSLYFFLSFFLSFFLSFFLSFSYSLKPMPTRFLLLLILFIYLSIYLSIYLSIYLSILLSVQVYTYLSIYLSIPYLSIYLSIYLSQSISICLSRFIIYLSIYCML</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B9K6</accession>
    <name>A0A812B9K6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_12697</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000424">
        <property type="protein sequence ID" value="CAE1173483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B9K6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1173483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="262" mass="31090" checksum="B12691EDFAD184C5" modified="2021-09-29" version="1">MFSLCQATVKVDKVLRFKSSFWHRHQMIFRLSYSIYLSHSDQVSLILSIYLSHSDQVSLILSIYLSIYLSIYLFLIRSLLYLSIYLSIYLSIYLSIYLILIRSLSYSIYLSIYLSIYLSIYLFLIRSLLFYLSIYLFLIRSLLFYLSIYLSIYLSIYLSIYLSLSDQVSLILSIYLSIYLSIYLFLIRSLLFYLSIYLSIYLSISDQVSLILSIYLSIYLILMRSLLFYLSIYLILIRSLLFYLSIYLSIYLSIYLSISVGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BA12</accession>
    <name>A0A812BA12_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_13655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000458">
        <property type="protein sequence ID" value="CAE1175358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BA12"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1175358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="225" mass="25909" checksum="6C9830B47611A972" modified="2021-09-29" version="1">MDTFSYTLSLISLFPHSLSLSLFVYLIFLSLHFVALSLSLYLSIYLSIYLSIYLSIYLSLHSLLFLRPFFFYFASLSPSLSLSLSLSLSLSLLSQCRSLFSLTFVYFFSVFFSLFFPPAFSLPFHCLSILLFFSYSISLSISLSLSHSHFSLSHFPLSLSHSLFSLYLSLFSPIFFSFFSFFFPPTFSLFHSLFFALFSYSLSLYISISLSHFHFLALSLSFFIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BAI1</accession>
    <name>A0A812BAI1_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SPHA_16225</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="CAHIKZ030000568">
        <property type="protein sequence ID" value="CAE1226890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BAI1"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000449">
        <property type="entry name" value="Probable ATP-dependent RNA helicase DDX41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="124"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="7">
        <location>
            <begin position="299"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAE1226890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="339" mass="38001" checksum="D6E580B35E2EEB87" modified="2021-09-29" version="1">MEADGFPVLRCALCIGGMPVKDQIELIKRGVHIMVATPGRLMDMLDKKMITLDVCRYLCMDEADRMIDMGFEEDVRTIFSYFKAQRQTLLFSATMPKKIQNFARSALVKPVTVNVGRAGAANLDVVQEVEYVKQEAKVVYLLECLQKTSPPVLVFAEKKQDVDAIHEYLLLKGVEAVAIHGGKDQEERTRSVEQFRNSQKDVLVATDVASKGLDFPDIQHVINYDMPEDIENYVHRIGRTGRRGKTGIATTFINKTVDKSILLDLKHLLLEAKQKVPPFLATLQSESEKYLDIGGEIGCSYCGGLGHRIADCPKLEALQTKQAQNIGRRDYLAHNAADW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BE74</accession>
    <name>A0A812BE74_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mitogen-activated protein kinase kinase kinase 19</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">SPS1/STE20-related protein kinase YSK4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SPHA_15834</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Farmed</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="CAHIKZ030000554">
        <property type="protein sequence ID" value="CAE1226008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BE74"/>
    <dbReference type="OrthoDB" id="10020384at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000331">
        <property type="entry name" value="Mitogen-activated protein kinase kinase kinase 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11584:SF369">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 19-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11584">
        <property type="entry name" value="SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="320"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="196"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00080573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAE1226008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="597" mass="66932" checksum="4B2E2AD5F9991324" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BIA7</accession>
    <name>A0A812BIA7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_18073</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000648">
        <property type="protein sequence ID" value="CAE1231358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BIA7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1231358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="244" mass="27860" checksum="CA9F3F08EECA8DAB" modified="2021-09-29" version="1">MCNYFSFVYIFSLFFVISLFLFLFFFQSLFFPYFYLSLSLISISLFPLFLSLSSTLVSISIHFPPLFLSLFVFLPCFYLSSFPPLFLSLFFSSLISLSSFPLYFSLCFPPLFLSLYFSSLVSLSLSFPPLFLSLSLFLPCFSLSLFSSLVSLSLFSSLVFSLSFSSLLSLFFLLVSLSFFLPVSLSLFSCLLLLNNSFLFLFTLFSSLLTFLLSFQYLLSSLFFHLILSHTFRSLSLSPTATNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BJS0</accession>
    <name>A0A812BJS0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_18919</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000684">
        <property type="protein sequence ID" value="CAE1233350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BJS0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1233350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="181" mass="21340" checksum="30C4B1AD6385065D" modified="2021-09-29" version="1">MDNTPSQADYVVYFVYLSIYLSIYLFQSLHIYLSIYLSIYLSIYLSIYCSVVIMQVLVKTGLFIYLFIYLFIYLSIYLSIYLSIYLSQLDSTDLSLSINILSLSVSFFLSFFLSFFLSFFFSFFLPSLHLSIYLSIYLSIYLSFFTDLSLSIYILHCPFLSFFLSFFLSFFLSFYACVRAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BKD9</accession>
    <name>A0A812BKD9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_22096</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000813">
        <property type="protein sequence ID" value="CAE1239889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BKD9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="331"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="361"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="400"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="458"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="484"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="510"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="541"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="564"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1239889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="596" mass="70269" checksum="2529FA65D6BF22D5" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BKS9</accession>
    <name>A0A812BKS9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_19413</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000705">
        <property type="protein sequence ID" value="CAE1234618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BKS9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="279"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="353"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="413"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="451"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="475"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="511"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="617"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="652"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1234618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="721" mass="86149" checksum="19E1DCF3A489B5D5" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BM42</accession>
    <name>A0A812BM42_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_20185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000740">
        <property type="protein sequence ID" value="CAE1236328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BM42"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1236328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="159" mass="18771" checksum="6C12800892772B35" modified="2021-09-29" version="1">MHKCTTDIFEPTIKYLSIYLSIYLSIYLSIFARSIPPPMSVTYKMADISYLSIYLSIYLSIYLSIYLSISFDHIYLSIYLSIYLSIYLSLIISIYLSISIYNEAYLLNRQDVFLNKSDIFLLNIRKNKISIYLSIYLSIYLSIYLSISACRFLIFCSRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BMF9</accession>
    <name>A0A812BMF9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_18222</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000657">
        <property type="protein sequence ID" value="CAE1231689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BMF9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1231689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="199" mass="22307" checksum="6DAF35D3B407F344" modified="2021-09-29" version="1">MLQEFPNNVGGGGEEWGFDIWQKQNAESFIGIQWKDLTFKKPSINTLTYPTLFFFHLPRLLSIFPSLYLSLFFPSAHLPHNLFPIRLSFLLSPLPLSSIFIFSIPSLLHSIPILLASSSNSLSLLVPLLSSISISLTIHSLSPNPIQTTSLPSPFIIYFFFNLSLSLCLSLPVILLIFLTSFSPFHACIQSHNLSIFLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BNY3</accession>
    <name>A0A812BNY3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SPAG1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SPHA_19045</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000690">
        <property type="protein sequence ID" value="CAE1233676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BNY3"/>
    <dbReference type="OrthoDB" id="2942533at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006626">
        <property type="term" value="P:protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051982">
        <property type="entry name" value="CiliaryAsmbly_MitoImport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025986">
        <property type="entry name" value="RPAP3-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45984">
        <property type="entry name" value="RNA (RNA) POLYMERASE II ASSOCIATED PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45984:SF1">
        <property type="entry name" value="SPAG1 AXONEMAL DYNEIN ASSEMBLY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13877">
        <property type="entry name" value="RPAP3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="RNA-polymerase II-associated protein 3-like C-terminal" evidence="6">
        <location>
            <begin position="178"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="52"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="143"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAE1233676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="301" mass="33092" checksum="FBECF00DBC71BE2D" modified="2021-09-29" version="1">MFRRAQAKKLKQHYRESISDLKNLLTMDPKNSAAKKELEVVKNFWRQELNAMKASMGEGKSKKDSNKCNQESNTVPPAPSGGANGSGKKGSKQRTRVCVHDVDEDNNSSSSSSSSSQSKSPSVPVTKSHGKHHKNSAPKKAEGNTQQNQAPSNNKKGCKSGGRTAPPPPVAAPHIDKATPYEFLKAWNSLKTVRNTKPYADLLAQVPPEDLPKMISNKLDAAMLNLITRCVSEHYADRGTAELGLQILSNVTKVERFQTIAMFMSSKEKSDLLSLLETLAANQTLYGEEEMQKLKHEYGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BP84</accession>
    <name>A0A812BP84_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_20359</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000746">
        <property type="protein sequence ID" value="CAE1236601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BP84"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1236601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="316" mass="37196" checksum="14035D7CB39E49B3" modified="2021-09-29" version="1">MQDSFLLLYLMLLSVCFYSLRPYALHDFNHVENLSIYLSIYLSIYLSIYLSIFIYLFICYLPKDDSSDSVTITLSIHTSILSTFLSIFISSINYFCFILINVLLPVVIYLSIYLSIYLSIYLSIYLSIYLSICIYLSTSLYLSIYLVCIYLSIYLSIYLSSLLYISIYLSSLYITIYLSIYHLSIYLVFCIYLSIYLSIYLVCIYLSIYLSIYLVCIYLVCIYLSSFIYLSFISIYLVCISIYLSICIYISTSLYLYLSIYLSINLQRYLSSLYIHRLIYLLSSFLVCMYYQTFAVYFYLVCISNLSKNIFSFVSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BRH3</accession>
    <name>A0A812BRH3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_21452</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000787">
        <property type="protein sequence ID" value="CAE1238706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BRH3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1238706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="202" mass="24178" checksum="E984B2C87CAB4376" modified="2021-09-29" version="1">MRGSILPREAFAVSLAMPKIRIYLSIYLSICHIKTSLLHLFYKFLPLFISLSLSLSLSLSRSLYPPSLSLYLSLYLNFRSVFRYLFFLSFLICSFFPFLIFIFFPTFTFFFPSHSFFLIFLLIPLLIFFLFFPYSFNFISSFLFFHSSLLHFFSFFLFSFFPPSYTSFPTLFLSFALIRSFFNFCFSFFYFVVSVFFLIFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BSP1</accession>
    <name>A0A812BSP1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_22064</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000813">
        <property type="protein sequence ID" value="CAE1239956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BSP1"/>
    <dbReference type="OrthoDB" id="6213709at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1239956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="156" mass="17127" checksum="952EC3818E59022E" modified="2021-09-29" version="1">MKPSLLSIKTTMKPSLLSIRTSMKPSLLSIKTSITISHLLSIKTTISSLYKGAFHLLSIKTSMKPSLLSIKTSMKPSLLSLKTSMKPSLLSIKTTMKPSLLSIKTTMKPSLLSLYKETTMKPSLLSIKTSMKPSLLFSLHSIKTTMKPSLLSIKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BX75</accession>
    <name>A0A812BX75_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_24617</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000921">
        <property type="protein sequence ID" value="CAE1245144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BX75"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="570"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="604"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="638"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="670"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="700"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="725"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="750"/>
            <end position="771"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1245144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="787" mass="89777" checksum="AB45A11F3B80A0B0" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BXJ3</accession>
    <name>A0A812BXJ3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SPHA_24015</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="CAE1243859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A812BXJ3"/>
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            <begin position="1"/>
            <end position="492"/>
        </location>
    </feature>
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            <begin position="28"/>
            <end position="334"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50855"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="531" mass="66957" checksum="D1C7471412A95CE8" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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    <name>A0A812BXZ8_ACAPH</name>
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        </submittedName>
    </protein>
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                <person name="Li R."/>
                <person name="Bekaert M."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
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    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
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    <sequence length="170" mass="19309" checksum="D0761EFFFC412623" modified="2021-09-29" version="1">MQIDNIYLSIYLSIYSIYLSIYYVRVNLSIYLSIYLSISFYLLSICSLFSSPQRPLSVSFGNLFLWAPAQGLEWGMMCSGNASVPKTTNHCSPCKCQNSGEPLFPPLKFYLAFSFFWSPDQTQFLLPLCEYLSPSLPEKCRKSCALPRISPGPLPFCSPGQTCLQELYHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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        </submittedName>
    </protein>
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            <strain evidence="2">Farmed</strain>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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    <name>A0A812C0F7_ACAPH</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">Farmed</strain>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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            <end position="235"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAE1250408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="250" mass="28457" checksum="D4E22B7C273C1221" modified="2021-09-29" version="1">MYPFLCSSLSFFLSGFHFIFKMYPFLSFFLSFFLSFFLSFVSILSSKCILFSLSPFFNILLLFHTSLSFSSLFYLQYLSLSLPALSLSIYLSYSLILWDTSLSVYFSLSLSLSFFLCLSIFLAIIFTAISLSLSLSQAVYLSISHPAGECYLSPYHSLYSSISFSVSLSLSSFNLSLFCSLSLYLLLSLFLSVFLLIFFLLFLSVDLSVSLFEIFHLSRFFNILCSRLIFSLSLLRLSVSLNLANHLFIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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        <lineage>
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            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001162">
        <property type="protein sequence ID" value="CAE1254942.1"/>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C471"/>
    <dbReference type="Proteomes" id="UP000597762">
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    <proteinExistence type="predicted"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="81"/>
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</entry>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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</entry>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="662"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="763"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="786"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="803"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="820"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="856"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="871"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="882"/>
            <end position="891"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1254376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1120" mass="126180" checksum="280DD3350892F13E" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CAV3</accession>
    <name>A0A812CAV3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_31462</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001293">
        <property type="protein sequence ID" value="CAE1258961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CAV3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.330">
        <property type="entry name" value="Nucleotidyltransferases domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1258961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="414" mass="44156" checksum="86CAB1629AE6FE8E" modified="2021-09-29" version="1">MREKTTEEERKWRQSLEDKENLLEEAGKWLLDLRHLLVASIDEEDVVSGVQSMEAEFSGRLHESFFPVEEGHFVVTFPEWCQLSLNQLQEEIMEFTVKAWHPKELELEREFCLQDSKLRRILSMAVSDEDGHLFVVDGGDKSINEFGETGEFVEQCPVQDEGFFPWDICCLSQDNFVVCGEGLSPPPASKFHPFFPPSPLNCLSLFLFFNLPPPPLTFSLSLYLLLVVQSAIHSSSATSSIASSTAIPVETSNVSAAASTLSAAASTLSAARFNIYAATSILSAAASTLSAARPNLSAATSILSAATSTLSATTSTLSAATSTLSAARPNLSAATSILSAATSTLSATTSTLSAATSTLSAARPNLSAATSILSATTSTLSATTSTLYTATQSPSKSSDQCCETSAIPLSCEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CBD2</accession>
    <name>A0A812CBD2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_31711</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001310">
        <property type="protein sequence ID" value="CAE1259494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CBD2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="337"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1259494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="359" mass="41868" checksum="8C91BD25C856C151" modified="2021-09-29" version="1">MPALKLLQYPALLQHPAHSCRSLFEVFSYFLSFSFRHLGAWLTIKQKMHSLSLSSWYNSIFTQDGLFFLSFPSHALFKGLVTVETAFFLFDIAAFRIRRKTGPSIRLGDQFSSQFHKHIFSAHMPRHLPDILPAHRPRPKLTFPFHYSFLFSSCHVAFFIKIVFFLYTLFSLFIFSLIIISLTFSFFSLIIFFISFPNFISHTIFGYLTSPLHYPSFSFPNFISHTIFGYLTSPLHYPSFSFPNFISHTIFGYLTSLFIIHLSLFLTFYISHTIFWISYLPLFIIHLSLFLTLSLTLSLDILPPLFIIHLSLFLTLSLTLSLDILPPLHYPSFSFPNFYLSHYLWISLPPLSLSIFLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CIQ5</accession>
    <name>A0A812CIQ5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_35547</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001532">
        <property type="protein sequence ID" value="CAE1267313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CIQ5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="363"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1267313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="386" mass="46609" checksum="B8123EC220C9BA1E" modified="2021-09-29" version="1">MLFIFLIHFEFLHVSIFFLSFFLLFSFSSLSFLFFFLFSFFSLFLSFLFFFSFFFLSLFFFFFSFFFFSFFSSLFFPIFLFSFFSYFSLLFFFPISFFSFSSLFLSFLFLFSFSFSSFSSLLLSLFLSLLLSLLFFSSFSHLFRFPFSFSLFLLSFFSFSFSLLLSFSFLFYFLFSFSIFTFNLLYVFYFHRLFMIDDLPPPLLFSSSSSHFVVVLFGYSSSPPLLFFSFSPFFSFPRLLFFCNPVFIFSFFVFFSNFFSFSDFFFSLSVFFFFSFFHSLYSFSSSFLPFLEFLRFFNFSLPPTSLFFPSFISFFSLQLHFILFFFSTYFPSPSFRLFLLFILNLSPPLFLSLSYLIPFTFSFLLLLALFLIFFNFAYLFLLSLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CJI9</accession>
    <name>A0A812CJI9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_35887</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001557">
        <property type="protein sequence ID" value="CAE1267903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CJI9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1267903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="177" mass="16740" checksum="A6CA0B790FDD3EE5" modified="2021-09-29" version="1">MSATSTVPSDIASQPPMSATSTVPSDIASTSASTPAMSATSTVPSDIASTSASTPAMSATSTVPSEIASTSAPTPALSATSTVPSDIASTSASTPAMSATSTVPSDIASTSASTPAMSATSTVPSDIASTSASTPALSATSTVPSDIASTSASTSPLLQCTVPSDIASTSASSNVSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CKN6</accession>
    <name>A0A812CKN6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_35908</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001557">
        <property type="protein sequence ID" value="CAE1267984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CKN6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1267984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="277" mass="32840" checksum="E48EFA6E5C81FF57" modified="2021-09-29" version="1">MFYLIICLLLLVFIYYLPHLCSPLPSLSIYLSIYLSIYLSIYLSISIIVIHIYLSIYLSIYLSIYLYVHIYVFIITVHIYLSIYLSIYLSIYLYHSYSYLSIYLSIYHICLSYLSAVSYHIYSSIYLSISIISFIVIHIYLSIYLSIISVHIYQLFISIYLSIYLSICSHLCIYHNCSYLSIYLSIYLSISIIVIHIYLSIYLSIYLSIYLSYLFISISCSYLSIYLSIYLSIYHRSVHIYLLIFISFYHSCSYLSIYLSIYLSIYLSIYLSISFML</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CQ22</accession>
    <name>A0A812CQ22_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_39692</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001861">
        <property type="protein sequence ID" value="CAE1275859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CQ22"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1275859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="174" mass="20871" checksum="05D3019EEDFBF6AE" modified="2021-09-29" version="1">MYIHIYLSIYLSIYLSIYLSIYLSIFISIYLSIYLSIYLSIYLSIYLSIYLFQYIHIYLSIYLFQYIHTYLSICIFFILRQANRSETVSEDRTHSVCQLTIVLSSAFQSLRLCDSCDNLLVLYVSHSFIYLSIYLSIYLSIYLSIYLSIYLSIYHDAQYVYERIFMLMFFNAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CQ70</accession>
    <name>A0A812CQ70_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_41514</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001998">
        <property type="protein sequence ID" value="CAE1278906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CQ70"/>
    <dbReference type="OrthoDB" id="200110at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029090">
        <property type="entry name" value="DUF4659"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33663">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33663:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1278906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="171" mass="20308" checksum="BAF5306C0056F3D6" modified="2021-09-29" version="1">MTSVPENIPKLNLYNFEEPQYEDCDYVLTSPRSLEACSRLNIKPVDLLHKPLEEFKEELQEYDLQPSTIYFFYNEHENKRQNNLQRCWEERSQIIKEEMEEGKKAALKEFSNDDLTNQEFSAAIVPVYNYKIDDILGYGDTEAFTQKQRTRSSLSNDRITKDIINEWYLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CQF4</accession>
    <name>A0A812CQF4_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lipid-binding serum glycoprotein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_41631</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002009">
        <property type="protein sequence ID" value="CAE1279128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CQF4"/>
    <dbReference type="OrthoDB" id="10255543at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.20.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017943">
        <property type="entry name" value="Bactericidal_perm-incr_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032942">
        <property type="entry name" value="BPI/LBP/Plunc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001124">
        <property type="entry name" value="Lipid-bd_serum_glycop_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10504">
        <property type="entry name" value="BACTERICIDAL PERMEABILITY-INCREASING BPI PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10504:SF131">
        <property type="entry name" value="BPI2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02886">
        <property type="entry name" value="LBP_BPI_CETP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00329">
        <property type="entry name" value="BPI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55394">
        <property type="entry name" value="Bactericidal permeability-increasing protein, BPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipid-binding serum glycoprotein C-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1279128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="210" mass="23827" checksum="6AA521BA8D4BFD80" modified="2021-09-29" version="1">MLYLQISDHLFNSYCRAAFMHNMLSFDVTDYEIPGHLLKTSCREGEACIGTILPVIGLRYPNETVRLSMANRRAPHWLFDEIIQLTLKGCLSFDIHLRNGSTVNIFKLDMDLSAHMSALIENSKVFSEIIDLNFTTSKIRGKIFQSNFNFTNLLRMVDTVVRNSIIPKINEQGRIGLPLILMDGASLQSTSLKVGKRCLIIGTNFHIDFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CSA3</accession>
    <name>A0A812CSA3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_39176</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001807">
        <property type="protein sequence ID" value="CAE1274975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CSA3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="355"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="399"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="434"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1274975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="455" mass="57200" checksum="01898CDF2BBF4ED6" modified="2021-09-29" version="1">MVNRPNKFWTHFNWSFFILFLIYSLLFLSHCYLSFFPFIFFHSFLLSFFFDSFHYYDCIYYSFLFCLYSFVRLFFLILFILYFSFLLFLFRFLYFRFVSLFPFRFFISVSFLYFCFVSLLAFRFFISVWFLYFCFGSLFSFRFVSLLPFRFFISVPFLYYRFVSLLLFRFFITVSFLYFCFVSLLPFCFFISVSFYFCLVSLFLFGFFISVSFLYFRFVSLLAFRFFISVWFLYFCLVSFFYLVSLFRFVYLFSFVSLLAFRFFIFVWFLYFCFVSFFLLPFCFFISVSFRFFFRFVSLFRFVFFFVYLFVWFLYFCFGFCLFLYFCFSLFLFRFFIFFRFFISFRFFISVSFLYFCLVSLFLFRFFIFVSFRFFITVSFLYFRSVSLLPFRFFTSVPFLYYCFVSLFLFRFFITVLFLYFCFVSLFPFRFLSLYFTVILMLTFLSLSIFFLSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CTN3</accession>
    <name>A0A812CTN3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_43233</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002157">
        <property type="protein sequence ID" value="CAE1282096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CTN3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
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<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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    <protein>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="6" xmlns="https://uniprot.org/uniprot">
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </evidence>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
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        </submittedName>
    </protein>
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            <strain evidence="2">Farmed</strain>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="233" mass="26905" checksum="26258A172B777751" modified="2021-09-29" version="1">MKDPPCSPSSFSNFTICFFLPFIPDNIFLTTCGSVFIGFKLQNISIRKPCVISIYLSIYLSIYLSIYLSIYLSITVYSYLSIYLSIYLSIYLSITVYFYSISIYLSIYLSIYLSIYLSIYLSLSIPMYVCMYLSIYLSIIISLSLSLSLYLSIYLSDCLFLSIYLSIYLSIYLSIYLCLFISRLTTISHHGKNESINNTIFLSIYLSIYLSIYGSLSAAFFLFYLNSLFKHQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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                <person name="Bekaert M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">Farmed</strain>
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    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
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        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1288430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="272" mass="31401" checksum="3B0A55A3F4D39AC9" modified="2021-09-29" version="1">MASEANNFTSIYLSIYLSIYLSIYLSMILCSSISMQLPVYSYLSIYLSIYLSIYLSIYLSIYLSMILCSSISMQLPVYSHLSIYLSIYLSIYLSIYLSMILCSSISMQLTVYSHLSIYLSIYLSIYLSIYDTLFIYLYATPSLFTSIYLSIYLSIYLSIYLSIYLSMILFYSSIYSSIHLSIYLSIYLSIYLSIYLSMILCSSISMQLPVYLHLSIYLSIYLSIYLSIYLSMILCSSISMQLPVYSHLSIYLSIYLSIYLSIYLSVEHALVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D6L6</accession>
    <name>A0A812D6L6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_50817</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003021">
        <property type="protein sequence ID" value="CAE1295253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D6L6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1295253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="293" mass="34822" checksum="51EE65A7D6E53135" modified="2021-09-29" version="1">MLTHVTNDATKLVHVISLFSLLNLFNFIFSFAFVIFFLSITICCLLSSPTSFFLSFFLFFCRRSLFPFSISKLSFFSFFFTFFLVQFFFVLFSTLFFLSFFLSFFLSFLRSFSIYLFLSFFLSFFLSVTDLFLSFPCFSESFFSNFLSFSLTNNVFSFFFTFYFCPIIFSLSFIIPFILSSHYRNFFLFYAFIFRISFFKYIFLFTSFLSLFSFTSFFVAFFLPFFIYFFCHTYFLLCSLSCFISSVSFNTLWIFSTLLFSLSLSPPLSLPLSLSLSLSYPSTFLFIYLLSFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D9U1</accession>
    <name>A0A812D9U1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_49048</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002777">
        <property type="protein sequence ID" value="CAE1292061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D9U1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1292061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="185" mass="21728" checksum="BF1408B9AB491CA7" modified="2021-09-29" version="1">MENESCVLVFPYMLTVTRLPHTVRNFCHQTYFTLTIFVGGIVTITVDFVVVTRTVLFLFFFSPLVAGRIITFTCTKHTATYIFPYYGLFKNRSHQNKYHSSSSSSSSSSSSSSSSSSSFLYNFFLTLFHFNFIYISLSHPYYYYCYYYNSSFFFYPNFISCFSFSSSSSSASFFFVFFFFFFFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DB92</accession>
    <name>A0A812DB92_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_52024</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003205">
        <property type="protein sequence ID" value="CAE1297482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DB92"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="377"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="402"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="443"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1297482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="465" mass="52322" checksum="467DC474B86CEA21" modified="2021-09-29" version="1">MIFENKKFSLSFIISSTDFHSFIYLQVHIYLFHLVHIYVSISVCAYLSIYLSQSFHIYLSIYLSQSDSVTHFLSTFLSLSISLSLCLFRFHIDERKFLSLSLSLSLSLSLSLLLSSFSLSLILYSLAFHNLYSSSLCTCLSLSLFSFSFSLSSYRSLFISLCVFAVSLNLSSLSLLYHFPPLSIFLSLSLSLCLFAVSLNLSSLYVSSLSLSSSLSVFSRFLSIFLLCLFSSLSLLLPLSLSLHFLSIFLLYHIFSLSLSFILSFSLYLRGFSQSFFYICLFSLFHFSCLCVFSQSFFSNFLFSLSVSSTPSLFLFAVSLNLSSLSVSSLLSLSSMSLSFISPSFLSKFLLSLFPFSLSVVLFHPPSPSLSLLYHNFSSLFHLSSLLIFFLHVFISLYHSLFYFSSFLISSLSLSLSFLFLSLTHTLLLSHYVPSLSPPPLSLSLSLFLQCLQGYCSIGYFGVVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DDA8</accession>
    <name>A0A812DDA8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_53795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003433">
        <property type="protein sequence ID" value="CAE1300335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DDA8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="351"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="383"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="411"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="440"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="467"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="503"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="541"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="571"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="596"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1300335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="616" mass="73739" checksum="F61DE82D03FE86D7" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DH53</accession>
    <name>A0A812DH53_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Microtubule-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SPHA_55243</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
            <location evidence="1 6">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003660">
        <property type="protein sequence ID" value="CAE1302805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9378527at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031175">
        <property type="term" value="P:neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027324">
        <property type="entry name" value="MAP2/MAP4/Tau"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001084">
        <property type="entry name" value="MAP_tubulin-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11501">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11501:SF18">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00418">
        <property type="entry name" value="Tubulin-binding"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00229">
        <property type="entry name" value="TAU_MAP_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51491">
        <property type="entry name" value="TAU_MAP_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="1669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2060"/>
            <end position="2091"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2104"/>
            <end position="2171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2335"/>
            <end position="2359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="115"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="132"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="172"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="187"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="242"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="255"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="398"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="535"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
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            <end position="594"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="595"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
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        </location>
    </feature>
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        <location>
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        <location>
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        <location>
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            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1071"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1082"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1134"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
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        <location>
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        <location>
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        <location>
            <begin position="1404"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
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            <end position="2143"/>
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        <source>
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        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000686"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAE1302805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="2485" mass="259898" checksum="C3B089A578969B3C" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DHN1</accession>
    <name>A0A812DHN1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_53170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
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            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="protein sequence ID" value="CAE1299349.1"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAE1299349.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DIJ6</accession>
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        <submittedName>
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        </submittedName>
    </protein>
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    </gene>
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        <dbReference type="NCBI Taxonomy" id="158019"/>
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                <person name="Bekaert M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="protein sequence ID" value="CAE1300168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12354:SF1">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        </location>
    </feature>
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            <begin position="180"/>
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        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF05004"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAE1300168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="280" mass="32048" checksum="468CD90EB7DD7957" modified="2021-09-29" version="1">MASLEQVFRASYLKGEKCATQNTAISSFHCSALSAWTLLLSIAPDSCIQEMTESYLSKIIGLLESPDVELRIVAGETIALMYELQRGIDEEFEGENMSNLCESLKHLATDGSKHRAKKDRRQQRSTFRDVLRSIEEFEYPAAMIKIGSECLYLDSWARKKQYDSFCQLLGSGTHQHFQVNLLLRDVFDLGAPPLVVDSPNQRARKMTKGERNFINITAEKRRTRARAKNRDKRSVTVSFHRFLADEPFALSFSFHMFDAQQTPAVHDKHHTIDDFLLKLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DJ49</accession>
    <name>A0A812DJ49_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_54613</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003556">
        <property type="protein sequence ID" value="CAE1301721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DJ49"/>
    <dbReference type="OrthoDB" id="10649571at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032480840" evidence="1">
        <location>
            <begin position="28"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1301721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="177" mass="18841" checksum="1B3C878F10012FAB" modified="2021-09-29" version="1">MLIGKEIFLFFISSLSLSLSFSPSLSSSNIRMFRPNSNLKPYLTLQPILSAKIIVPPLQPILSAKIIVPPPQPILSAKIIVPPPQPILSAKIIVPPPQPILSAKIIVPPPQPILSAKIIVPPPQPILSAKIIVPPPQPILSAKIIVPPPQPILSAKIIVPPPQPILSAKIIVPSSPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DJW1</accession>
    <name>A0A812DJW1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">TUBA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SPHA_55064</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Farmed</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003633">
        <property type="protein sequence ID" value="CAE1302447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DJW1"/>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000005">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000024">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0493">Microtubule</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="8">
        <location>
            <begin position="49"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAE1302447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="212" mass="23497" checksum="BEA54D6F004E4BDE" modified="2021-09-29" version="1">MRECISVHVGQAGVQMGNACWELYCLEHGIQPDGQMPSDKSIGGGDDSFNTFFSETGAGKHVPRAVFVDLEPTVIDEIRCGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIVDLAPTVVPGGDLAKVYRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGVDSGDMGEEGEEEMEEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DKG4</accession>
    <name>A0A812DKG4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_55314</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003667">
        <property type="protein sequence ID" value="CAE1302908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DKG4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1302908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="164" mass="19016" checksum="1E9A7493012BDC44" modified="2021-09-29" version="1">MHDLPLSLSLSLSPSLSLPLSLSFPLSQKQIKRDLLLSVYLYVYLCQINHYLSIYLSIYLSIYLNLIIYEPTNIYHNLIISIYLSIYLSIYLSIYLSIPVCSLSITDCSLSIYLSIYLSIYLSIYLSIYLSQSVHYLSQTVRYLSIYLSIYLSIYLSMSVCLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DKZ0</accession>
    <name>A0A812DKZ0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_58287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003973">
        <property type="protein sequence ID" value="CAE1305937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DKZ0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1305937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="158" mass="18971" checksum="BC4214774F35E855" modified="2021-09-29" version="1">MLHLFIYLYLSIYLSIIIYLSIYLCFFLSSFFFLLHHGFLSIYLSIYLSIYLSIYLSIYNWDAEDFSARPRKDFDEMLMLRQFLRFVESVWAPKTFQNCNYLSVCLLTYFSVVHIYLPKYFAINNLFISPLSVSIYLCLSLSIYLSIYLSIYLSIYVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DLG3</accession>
    <name>A0A812DLG3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_55283</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003667">
        <property type="protein sequence ID" value="CAE1302969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DLG3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1302969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="349" mass="40186" checksum="2A79CF19ACCB2706" modified="2021-09-29" version="1">MYLSIYLSIYLSIYLSIFQNVSINYLSIYHNMSMFVYLSIYLSIYLSITICSYLPLTTCPLSIYLSQYVHVYLSIHHNIFISIFHSMFISITVNSYLSVYLSIYLSIYLSIYLSIYLLQLCSYLSIFHNMFIIYLSIHLSIYLSVCLSVIYRYNTIYLSIYLSIYLSIYLSIYLSIYLSIYPNFFISMYLSISSAPHLPTEASAPHLPTEASAPHLPTEASAPHLPTEASAPHLFIVASDNEEFLGQLRISPATPRVLTRNGHLYSCTRLPPESQIFFFRNFLFSRFSLSLSESIWTNNFFFFFFLHITAIFSSIAISLCLFFIYIVFESLSLSLSLSLSLSLSLSLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DLS2</accession>
    <name>A0A812DLS2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_56741</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003790">
        <property type="protein sequence ID" value="CAE1304058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DLS2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1304058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="317" mass="36387" checksum="B01109CEE4F8A1B4" modified="2021-09-29" version="1">MYFFLSTFMYRSIYLSHYGIYPSVYLSIYLSIYLSIYLSIYLSVSVYISLYAGINMHFIIFLPMCYICSYGSLYLCVLVIIYLSIYLSIYLSIYLLIDRSIYHVAIAHFFISLLISISPNIYLLISHLAINPSIFVAIIHLSLSLYLSLSLSLSHSLSIYLSFIYLSIYLSIYLSIYLSISVCLSVLTICIVCFFLFSLFLFFPFLIYLRVFVLLISICFSILVFLLFLILFCISSSSSSSSSSSSNPPPSSSNSPSFFLFLFLLVFNSCFFFIFFILFSLLLLLRLLSILLQRSPFLLSSSSSSSSSSSSLYYYYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DP12</accession>
    <name>A0A812DP12_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_57997</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003940">
        <property type="protein sequence ID" value="CAE1305621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DP12"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="299"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="331"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="365"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="389"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1305621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="438" mass="52280" checksum="194A876694341B29" modified="2021-09-29" version="1">MILSFFLSFQLPSVHQSFFLSFFLSFFLSFFLSFLSFFLNLMLTSCDYFFLSFFLFFFLSFKLPSIRPSFFLSFFLSFFLSFFLSFFLSFLISCLHLVILLSFFHASVRHSFFLSFFLSFFLSFFLSFLISCLHLVILSFFLSFFLSFFLNLMLTSCDSFFLSFFQASVLHFLSFFLSFPILNSSVFLSFSFLSFFLNPILPSFFSFLSFFLFLTQFFRLSFFLSFFLFFSFLISCLHLVILSFFLSFFLSFFLSFFQASVLHSFFLSFFLNPIPPSFFLSFFLSFLTQFFRLSFFLSFFLSFFLNLMLTSSSVLHSFLSFFSFLTQFFRLFFLFLSFFSFFLSFFLSFFLFLNPILPSITPFSFSIFFLNFVLLSLIHSFIHSFFLSFFLNLLLCASFFLFSCISIFFIKKSFVFHFFFSFLSIQKTPFCVTNPFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DPP7</accession>
    <name>A0A812DPP7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_58202</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003966">
        <property type="protein sequence ID" value="CAE1305820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DPP7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134:SF22">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134">
        <property type="entry name" value="OS08G0543275 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1305820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="176" mass="21573" checksum="0905AEACD8FF6BD6" modified="2021-09-29" version="1">MYKLLSFFFFIAEFCSYLSIYLCSYLSMFIFIYLHIYLSIYLSIYVHIYLSMFISIYLFMFISIYLSMFIYIYVHIYLSMFISIYISYLSISLSLYLCSIYIYIYIYIYVYIFMFISIYLSIYLSIDVHIYLSIDVHIHLCSYLSILSIYLSIYVHIYLSIYLFIRGLERLYEIFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DR31</accession>
    <name>A0A812DR31_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_58871</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004056">
        <property type="protein sequence ID" value="CAE1306699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DR31"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1306699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="248" mass="27660" checksum="98150923086B7C0C" modified="2021-09-29" version="1">MTLSFVLIICLSLFFTLPAYVTLSTSLSLSFSLSDYLPLPNIIPSLIMSESLSLVLCLNASHSGYIYFSLSLSLSLSLSHCISASLSIYIFISLSLSLFLILSLIIFLSALIYLLIIFCLPLIIFEYLHLSLSLSLSHTNSVCLLIFLSFSLLFFIFTSLSLSLSLSLVVFDYLTLYRSLFFFFFSLSLIIIVFRSVFSITVSLYPLISNVGVHDKSLSLSLSLSLSLFLSLSLSHRPSQTYIFSKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DVM4</accession>
    <name>A0A812DVM4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_63046</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004519">
        <property type="protein sequence ID" value="CAE1311668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DVM4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="279"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1311668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="340" mass="38835" checksum="6F8F5CF4C6F9D71E" modified="2021-09-29" version="1">MSIYSYLSIYLSIYLSVYPILHSFLSIYLSIYLSIYLSIYLSLSPLSLSLSLSIYIYIYIYIYIYIYIEWFFSFFFSPLLYLSLSIAFPLILSFCFFLSISLLLFPPSLPLSLCIFVYHRLDYVMSPMDIDSTFPLSPLSFLPPSLSLSHPLSFELALSISCSPSLPILFFLFLSLSLSLSLSLSLSLSHCLSIYLFLRPLFYVLSFSLRLSFFFSFSLSFFLSFPKSPLSFFISLSSLLSFFLPLHRSHSSYLSISLSLSIFFSFLPTPTLLFSHSPLFLSIFFLSYCISIAITLFLPFPLPRFPSLTLHRSTPLSLSLFTSATFSTMASHSVLANLYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DWA1</accession>
    <name>A0A812DWA1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_63548</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004553">
        <property type="protein sequence ID" value="CAE1312287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DWA1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="291"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="315"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="370"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1312287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="405" mass="48944" checksum="172D820F543F4EE3" modified="2021-09-29" version="1">MNTEIHNSLSLCLSLSIYLSIYLSIYLSLYLSVFQSIYLSIYLSIYLSIYLSFFISIYLSFFIFIYLSIFLSIYLSISVFSYLSIYLSIYLSIYLSIYLSISVCFNLSIYLSIYLSFFISIYLSIYLSIYLSIYLSVFQSIYLSIYLSFFISIYLSIYLSIYLSIYLSVFQSIYLSAYFIQPVFNSLYIISFIFVFLCFIFFSLFSLVLFYFILFLLLFSFSFFFFSPFLFFISSLFLEFHLFFKIFLSLIFSSPFSFFYFYLILLFSLQFLFYFLFIIFLSFFFRFSFCVNVSILAFFIPFFIIFINEFRLFSIFLPLFFLVFAFLFFSFVIIIFFLSFHHFFLFSFFLSFDSFFFLSFLLLIHTLSFFLLICLSFFLLIHTLSFFLLIFSFFLSFDSFFLSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DY36</accession>
    <name>A0A812DY36_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_64280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004626">
        <property type="protein sequence ID" value="CAE1313161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DY36"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1313161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="198" mass="22385" checksum="4F328A87D2B3ED21" modified="2021-09-29" version="1">MSIYLFVSFSVSISLSIVLHLSLFFNLCLSLFQFASFFSPSLIIFLSFSSSSIHSLIFLSSNFIDFTYFLSFFSPSSMHSLIFSFFLVTSIDLFFLSSCLSFIDLLFLFLCHILLYFFKSFFEALQTILEIIKTLFLSNSANSLSLLLSPPTLIGHYNCLSLISNPSLLQTQTLFAYSLSPILLFPPLPLTILHSLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DZY8</accession>
    <name>A0A812DZY8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_63365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004540">
        <property type="protein sequence ID" value="CAE1312067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DZY8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1312067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="229" mass="26032" checksum="AF42A5286217F379" modified="2021-09-29" version="1">MILFSSPLFPNHSILTLHFSFQTKPHSSCFHPSHSKTMSFFSHFPPLFPNRSFLVPFFFQTALFLFPSFSKSVFSFPSLSKPFFSSILPTTITLFPNHSLCVPHSFSLSTTHWPLSPDYFVLVPTSLSLFIFLLSVLPIILSCMFFSLPEYLNFIHLSFPSSSSSSFYPVAFFCHSFSFNSVVHHKALKIKNIRISLIKSKLTMPTASLHRSPSSHFASIHPSILPRFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E0L1</accession>
    <name>A0A812E0L1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_62544</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004476">
        <property type="protein sequence ID" value="CAE1311048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E0L1"/>
    <dbReference type="OrthoDB" id="6161790at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1311048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="164" mass="18739" checksum="F0D6FAFC3BDCD96A" modified="2021-09-29" version="1">MSISLHDSHVQLWLLLKQCDIYLSIYLSIYLSISVCSLSISVYTLSIYLSVCLSIYLSICVFQSVHYLFQYVCYIFHSAGYLSIYLSIYLTTYVSISLRVFPVEPHSYLSVPGYLNIFPYLSPPSSLPNTQCGCRRQLSREENNLRLSALVAPFFTLCPNDTQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E1P8</accession>
    <name>A0A812E1P8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_65517</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004724">
        <property type="protein sequence ID" value="CAE1314571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E1P8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032806235" evidence="2">
        <location>
            <begin position="19"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1314571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="268" mass="31861" checksum="9D89A8CE634EDB08" modified="2021-09-29" version="1">MGNFIYLLLACFLSNILSDSFSLFHLPIFLPLFSPRLLSPHPPLTPSIIPSFLEQIPNFFPLLPYQTSLWPQAFLSRLFVSLSRLHMTWPSVLNFSFHFVFSRPSFIFSLFLFLFFFLFFLLIRLQFLIVFHSFSFSFLFIWLQFFHSLICFLVFHSLILFLSSFLSSGFSFHSFSFFSPSSFFSSSIVFCFFAFHSLFHIPSSFFSSGFIFHSLILFRSLFIFLQSFYLATFFNCLSFFISFPFFFLFIWFHSFSSFISFSFFYLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E223</accession>
    <name>A0A812E223_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methenyltetrahydrofolate synthase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_64985</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004679">
        <property type="protein sequence ID" value="CAE1313943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E223"/>
    <dbReference type="OrthoDB" id="433414at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10420:FF:000001">
        <property type="entry name" value="Methenyltetrahydrofolate synthase domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002698">
        <property type="entry name" value="FTHF_cligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13017">
        <property type="entry name" value="5-FORMYLTETRAHYDROFOLATE CYCLO-LIGASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13017:SF0">
        <property type="entry name" value="METHENYLTETRAHYDROFOLATE SYNTHASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01812">
        <property type="entry name" value="5-FTHF_cyc-lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00015518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1313943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="300" mass="33467" checksum="F725C5E5777A5CE4" modified="2021-09-29" version="1">METPAEFVKKLGSSVTKQQIRQKVWDYLEAKNIANFPRPVHNRIPNFKGAATASDKVASMEVFKKAQTVKVNPDKPQEVVRFHTLEAHKTLLVPTPRLRTGLFNRITPPSQSKETFRKCATSQGVKEHSLPLSLDTKVKIDLIVIGAVAVSKTGLRIGKGEGFADLEYAMMVNMGAVDDNTVVVCSVHDCQVMDIPAELYNDHDLTVDYVVTPTQIIKCEGGTHSKPKGLIWSRLKVLFVLLFPGIVFKNAKTFLPFTLRATFTRGSLKPFQRQPACFMSDIQVLLLPLFLQLTIIAYDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E3I0</accession>
    <name>A0A812E3I0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_65401</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004722">
        <property type="protein sequence ID" value="CAE1314425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E3I0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1314425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="355" mass="42146" checksum="C31919306C84AEB1" modified="2021-09-29" version="1">MPHLSIYLSIYLSIYLSIYLSVILYQYMAISQVQTYFSFFLSFFLSLFHMSSLFLSFFLSFFLSFYASITIYVFLSDFYPIFSFLVFPSLFQSQNILSIYLSIYLSIYLSITSFFFLSFYFLSLFLFLSFYDNISLAISYKILLFFFLSKSIHIYISITSPLILLSVSITSYFFFLFLFLFLFLFIYQMIFLFSPCLSSLSIYLSIYLSIYLSIYLSISITSSFYLSIYLSIYLSIYLSIYHLFFLSFFFFFFSLSLSVTRFSFLFLSIYLSIYLSIYLSIYLSITFFVSLFHPYSYFCLSSLNTDRSPIIYLSIYLSIYLSISDHIYLRLSISIYLSIHLSQAVHIYLSIYLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E6N9</accession>
    <name>A0A812E6N9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_67339</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004879">
        <property type="protein sequence ID" value="CAE1316669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E6N9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1316669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="314" mass="36845" checksum="4F1F049D77DEA929" modified="2021-09-29" version="1">MFFFLLFLPHSLCVWVLYLHYLYMLPSLSVCLSVYLSIVFVIYLSIYLSYLLSIYLSIYLICYLSIFLSIVFVIYLSIYLSYLLSIYLSFYRICYLSIYLSIVFVIYLSIYRICYLSFYLSYLLSIYLSIYLSVFVSIVFVIYLSIVSVIYLYVLFPCILFFFSSRIISISFLFLSIWILRVIIFDLGSVRHLVSLSLPMFGFSMFLFSLSWYSASLHLIFLSIHLSIIIWYCNIFSLSLSLCNLVFFVLFILSHSLFFSLSLNLALYILSLYDLLSFLTNIIFPLNCSFFIPLDMKESSVLSICLGTARWCNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E6Y9</accession>
    <name>A0A812E6Y9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_69640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005098">
        <property type="protein sequence ID" value="CAE1319185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E6Y9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1319185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="169" mass="19461" checksum="6F84A82FBFAA721D" modified="2021-09-29" version="1">MFRTAVIVLHFFFVFFFTLPPRYVNSSSSCLSGCSIFFLPITILFLLLSSTPALVTFFAAVAILFFYYSFFSSSSSFSSFSPFLLVSFTFLHLHLSPSSNFFSSSYCFYFCITLQPPFPPASNSFFLFHSCSFNFLPPFLLLFLLLQNSSTSYSFFSFYQRLLLFLLLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E6Z9</accession>
    <name>A0A812E6Z9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_66855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004826">
        <property type="protein sequence ID" value="CAE1316029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="405"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1316029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="427" mass="47883" checksum="F386AA7A43518B0B" modified="2021-09-29" version="1">MAFHFLSLSPWLFSLSLSPWLSLSFFSLSLSISMAFHFLSLSPWLFLFSLSPWLFFSLSLHGFSLLSLSLHGFSLSLSLSPWLSLSLSLSHLFLSLSIAFLFLSFHFLSISMAFLFLSLSLHGFSFLSPWLFSLSLWLFLSLSMALAFSLHGFSLSLYLHGFSLSLSLSMAFLSLSLLLFLSLSLHGFSLFSLSFHGFSLSHFLSLHGFSFSLSLSPSLFTFLSLSLSPFHFSLSPWLFHFLSLLYLHGFGFSLFSLSIYLHGFSLSLSLSLSPWLFTFLSLFSLYLHGFSLFLSSLSLSPWLFFLSLSLSLSLSLFLSLSLSLHGFSLSLSLSLSLHGFHFLSLSLSMAFHFLSLSLHGFSLSLSLYLHFNSLSLSPWLFTFSLSFSPWLFFLSLSYLHGFFSLSLSISSSMLFSLSLSLSLSISF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E779</accession>
    <name>A0A812E779_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_66056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004759">
        <property type="protein sequence ID" value="CAE1315078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E779"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <begin position="40"/>
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    </feature>
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            <begin position="111"/>
            <end position="134"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1315078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="196" mass="22762" checksum="E049E43BC4C9FFE0" modified="2021-09-29" version="1">MFLCFVLLPKSIYLSIYLSIYLSIYLSFIFRNVSFSPSQIFLSFFLFSFFLSFSFMNIWGTQVYAYSIISQSIYLLSRSHNLSIYLSIYLSIYLSMFLDNLSIYLSIYLSIYLSVLSIPFITSPIYLSICFASYSSIYLSISRGSLTIYLFIHSISIYPSICFGLFLSIYHIIYLSIYLFWPSHSSIYLLVTAAPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EAT9</accession>
    <name>A0A812EAT9_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dynein heavy chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_71495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
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            <taxon>Sepiidae</taxon>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
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    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005236">
        <property type="protein sequence ID" value="CAE1321398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EAT9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
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        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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            <end position="50"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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    <feature type="transmembrane region" description="Helical" evidence="1">
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        <location>
            <begin position="848"/>
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        <source>
            <dbReference type="EMBL" id="CAE1321398.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="873" mass="102587" checksum="28095F9AFAB47CB9" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EDC6</accession>
    <name>A0A812EDC6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_71524</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005237">
        <property type="protein sequence ID" value="CAE1321447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EDC6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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            <begin position="6"/>
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        <location>
            <begin position="162"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1321447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="204" mass="23446" checksum="0631089E2C4ACD4F" modified="2021-09-29" version="1">MILATAFSFFLVCIIFSNYFPLISHILSLSLITHHLSCCFTFFFICFYTYMLFLLFIYFPLPTCLKFDLFSSCHLSYPTCTQVPQPTPFSLLQPHPLYFVSDALSISLSLSLSFCLVASITTSHGCCSSGSIRMRKRRNKHQHLELLSFLLIYPLYDASQATFFTFITTTIIIIIIHHLLSFLSIFLYHLLLYSSYCCLSHASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EFQ8</accession>
    <name>A0A812EFQ8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_71712</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005255">
        <property type="protein sequence ID" value="CAE1321664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EFQ8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="297"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="368"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1321664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="402" mass="47834" checksum="CA10D28184FBC254" modified="2021-09-29" version="1">MVINIGLSFFLSFFLSFFLFFSFFLSFFLSNYSTYIHILFRFFFFIRFFYIFFNFPSFISSLFHSLFLSIYPFLFSFSFFPFAYVTLFYCFLFSFCIANIYSYCVLPFFPFSFFLSVRLFYSFVSFFFNASYVYSHYTFSFFVMIFYFFISLFSFLHMFIHITPFFLSFFLSFFLSFLFNWPELNLQQIVCTLDLEVLNCAVLNCDAAIGRTHDGNFQQLCSFSPENLVNAPHHYPIHCYPLSTPYPILFFRIAPVTRFPFLISFPSLLRLLLLPFFSVLSSRPSRDALLRTGFLDLYHGCLVLHLIVECVTLESALMIPFKRTKRKKEEKQEETGSGDHWYFLARIYLSIYLSIYLSIYLSVRYLSIYLSIYLSIYLSICVCVCSYLSIYLSIYLSIYPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EG36</accession>
    <name>A0A812EG36_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_72489</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005327">
        <property type="protein sequence ID" value="CAE1322516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EG36"/>
    <dbReference type="OrthoDB" id="6122938at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1322516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="196" mass="21986" checksum="F0606E03F67BD40B" modified="2021-09-29" version="1">MENQPTATNKCAHKQAVANCQSGIQEAQNTGWQRKAAEIQSYADQRDLRSFYEATKEIFGPTCSSVGGLKDVDGATTITDSEGILARWRFHFENLLNDQVNTPDDLLRTTPQLPVRHWMALLPSIQDFNKALKRMRPGKAPGPDNIPLELLTHSGPEMKNRLMLLIFKIWETKTLPSDFRDATAVTTATTIGEYHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EGN6</accession>
    <name>A0A812EGN6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_73255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005370">
        <property type="protein sequence ID" value="CAE1323411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EGN6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="314"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="374"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="404"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="434"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="458"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="487"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="572"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="599"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1323411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="616" mass="72382" checksum="42197F8379FE95B7" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EHQ0</accession>
    <name>A0A812EHQ0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_71431</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005233">
        <property type="protein sequence ID" value="CAE1321324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EHQ0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1321324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="284" mass="33721" checksum="EEE71268D49B6B73" modified="2021-09-29" version="1">MNVNYLSFSIRLVIYVCLLFRAHNSFAICVCPLSIISYLFVIYLCPSSFYHFMYVLYLCPLSIIPDSYFSNICSLFIYIPLSILIRYLYMPIIYISIIPNSFKIIYNSFIRSFYLYIPIRSLYINDYYLFMIHYLSVIYYISIISYSFSIYVCYLSISIPMVIYTCPLSIIPYSLSISIIYLLLDILSLSMYVCNLSFTISSLSIFLIYLFFHIRSSSIYVHFLSILPYSFVIYICPFSVYSSIFVRHLYMSIFCLFFYIRSSSIYVHFLSIIPYSFFNFSSMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EJS7</accession>
    <name>A0A812EJS7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_74398</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005429">
        <property type="protein sequence ID" value="CAE1324709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EJS7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1324709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="165" mass="18983" checksum="CD12E775F9F22012" modified="2021-09-29" version="1">MSICIYLWHLFVSIYLSIYLSIYLSIYLCQSVSIYLSIFNKSRKLRILSIYHDLFIIYLSIYLSIYLSIYLSLLRIIIVIKTFPFKYIKKYVFLRAFVGSANEFIIYLHTQTYLSGKYPATMNISGIGCAESILPIPREIAEQVGTGTPSAVITSAGRHRLLSYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EKC6</accession>
    <name>A0A812EKC6_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SPHA_77116</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005505">
        <property type="protein sequence ID" value="CAE1327682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10072397at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060298">
        <property type="term" value="P:positive regulation of sarcomere organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045989">
        <property type="term" value="P:positive regulation of striated muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000425">
        <property type="entry name" value="Myosin light chain kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000107">
        <property type="entry name" value="Myosin, light chain kinase a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050958">
        <property type="entry name" value="Cell_Adh-Cytoskel_Orgn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006788">
        <property type="entry name" value="Myrip/Melanophilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080">
        <property type="entry name" value="CONTACTIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080:SF8">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04698">
        <property type="entry name" value="Rab_eff_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="549"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="651"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="418"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="759"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1290"/>
            <end position="1344"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1110"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="442"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="465"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="514"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="762"/>
            <end position="780"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAE1327682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1380" mass="154755" checksum="97E362EC668B9922" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EQN4</accession>
    <name>A0A812EQN4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">EPT1</fullName>
            <ecNumber evidence="7">2.7.8.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SPHA_77740</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.1" evidence="7"/>
    <dbReference type="EMBL" id="CAHIKZ030005521">
        <property type="protein sequence ID" value="CAE1328151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EQN4"/>
    <dbReference type="OrthoDB" id="196717at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004307">
        <property type="term" value="F:ethanolaminephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000016">
        <property type="entry name" value="ethanolaminephosphotransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014472">
        <property type="entry name" value="CHOPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414">
        <property type="entry name" value="ETHANOLAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414:SF71">
        <property type="entry name" value="FI05338P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="307"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="362"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="392"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="417"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="442"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="470"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="511"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="546"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="571"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="594"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="623"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="657"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="684"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="722"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="755"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="781"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="805"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="837"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="878"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="904"/>
            <end position="925"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAE1328151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="944" mass="113784" checksum="36A2C926ECB13B59" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EQU7</accession>
    <name>A0A812EQU7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein UXT,Protein UXT homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_78406</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UXT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005538">
        <property type="protein sequence ID" value="CAE1328775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EQU7"/>
    <dbReference type="OrthoDB" id="433124at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23158">
        <property type="entry name" value="Prefoldin_UXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003994">
        <property type="entry name" value="UXT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13345">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13345:SF9">
        <property type="entry name" value="PROTEIN UXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01502">
        <property type="entry name" value="UXTPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1328775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="152" mass="17870" checksum="03024AACF6B51C94" modified="2021-09-29" version="1">MDREEKILNYETFLNEKLRGDLKKILDQRDKVYQEISDYLQLKSVIERLQENETKEPLKTRVDLGCNFYVQAKVPDPTSIFVYVGYGFYVQFTFEQALKFIKQKTDLLTERTEALTKQSAVVKANIKLVLEGLREIHLIDDTPEKKQVDLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ERV3</accession>
    <name>A0A812ERV3_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SPHA_81185</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Farmed</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the recoverin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005626">
        <property type="protein sequence ID" value="CAE1332105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ERV3"/>
    <dbReference type="OrthoDB" id="191686at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000009">
        <property type="entry name" value="Visinin-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028846">
        <property type="entry name" value="Recoverin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055">
        <property type="entry name" value="CALCIUM BINDING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055:SF69">
        <property type="entry name" value="NEURONAL CALCIUM SENSOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13833">
        <property type="entry name" value="EF-hand_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="62"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="98"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="142"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAE1332105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="189" mass="21913" checksum="5F1CB2F68A6CE2AF" modified="2021-09-29" version="1">MGLKPSKKKLSKEDMQFLKKHTHFTERQIKIWYQGFMKDCPKGLLTKSKLMEVYSDLFRQGNPEAFCDHVFRTFDHDNSGHIDFKEFMLAISVTSAKDPKEKLTWAFTMYDKNKDGTIEKSEMVDIITAIYEMLGCSDSQEPPEERTEKIFKKMDVNNDGVLSREEFISGCLDDDDLRQMLTVDAICAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EYW0</accession>
    <name>A0A812EYW0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ZNF423</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SPHA_81161</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005625">
        <property type="protein sequence ID" value="CAE1332053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10014897at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF127">
        <property type="entry name" value="BLOODY FINGERS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="193"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="224"/>
            <end position="249"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <begin position="256"/>
            <end position="280"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <begin position="496"/>
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    <feature type="transmembrane region" description="Helical" evidence="7">
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    <feature type="transmembrane region" description="Helical" evidence="7">
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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        <location>
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        <location>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="1408"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1415"/>
            <end position="1440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="1468"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1510"/>
            <end position="1532"/>
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    </feature>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <begin position="1607"/>
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        <location>
            <begin position="57"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="85"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022771"/>
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            <dbReference type="ARBA" id="ARBA00022833"/>
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        <source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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            <dbReference type="EMBL" id="CAE1332053.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
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    </evidence>
    <sequence length="1654" mass="191667" checksum="F0148BD6943B1ACD" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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    <name>A0A812AJT5_ACAPH</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
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        <lineage>
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            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
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            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
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    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <source>
            <dbReference type="EMBL" id="CAE1139360.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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    <name>A0A812AM74_ACAPH</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
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        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
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            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
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        </submittedName>
    </protein>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">Farmed</strain>
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    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <dbReference type="OrthoDB" id="9397715at2759"/>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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</entry>
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    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_4734</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000154">
        <property type="protein sequence ID" value="CAE1156356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ATG8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="291"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="405"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1156356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="435" mass="49375" checksum="576A46B718CD5243" modified="2021-09-29" version="1">MSVSGGGREKRDCSRQPSRELTKERQKGSRERCPRSKRSRCCAPASSFGAREKKRVSLLRPLAGRDRTDTRPDDSFVSGIWVFYPSARRRNFAMKNSVAIILFSLSLCLSPTLYLFLSLFLSLQESSFSLSLSVFLPLSISFFLSFSLYKNHPFLSLYLFLSLSLFTRITFSLSLYLFLSLFTRITLLSLSLSPSFSLYLSLSFSLPLFIKITLFSLSLRLSLSISFFLSSSLYKNHPFLSLSLCLSLSLSLFFSLPLFTRITLFSLSISFSLFISFSLSFSLYKNHPFLSLYLFLSLSLSLSLSLSLFTRIILFSVSLSLSLLTRITLFSLSLYLSIYLCLSLSHTHTQTHTRTRARFLTLCLTIPRHPVLSPIIPPHQSLLACQYRETPVPWKKLYVPQTNSGTLILVLFHSLVITLSVASMSIIRQTMDCHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AU78</accession>
    <name>A0A812AU78_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_5144</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000171">
        <property type="protein sequence ID" value="CAE1157333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AU78"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1157333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="162" mass="18382" checksum="1EFB4D79B55EB7AA" modified="2021-09-29" version="1">MMKQKIRSLSLSSWYDSILARDGLFFRSSFLSLPSRALFKGLVTVETAFSLFDIAAFCIRSQNGSIHSTGRPILLTILQTHLFSPYTETFAKCLASLLAWRRLTFSFHYSFPFSSCHVVNFQNINFFLIMGGMGPSTPSLIFRVRESLVQNVSTYPNRNLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AZ69</accession>
    <name>A0A812AZ69_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_7435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000238">
        <property type="protein sequence ID" value="CAE1162818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AZ69"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1162818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="211" mass="24692" checksum="83BC5145FDDB7053" modified="2021-09-29" version="1">MCSLSLSLSREREREREREREICSLSSLWRHFLSFTPYLSFSISLSLSGGIFFSLFLGDFDFFSFYRILTAGDAHAPPSKRRYLFHLPIVCLSIYSYLFFCLFIIYLSIYLSIYLSRYLSRSLPYLSMLISYSFCSLSIYLSIYLSIYLSIYLCSYLYSVLLLIYLAVYLCLYLSQSVHYLSLSLSLSLSTYLRLFISVLVFLSLLPMSEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AZ73</accession>
    <name>A0A812AZ73_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_7751</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000249">
        <property type="protein sequence ID" value="CAE1163607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AZ73"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1163607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="354" mass="43283" checksum="842B88C127D96F8F" modified="2021-09-29" version="1">MFLQTKQIKPLHEHRFYNLFACFFLSLFFAFHSFFHPFSFSFFFSFFLPFSISFIFFLSIFLSLFYSFLLSFLSFSFSLSFFLSFFFLSFFLSFFLVTCHIFYPLYCFSTHAHFILFVIFIFLLLFIAFVFIFVLNFHFSFLVFFSTSFFSLNVFLFFLPFFSLFFLKILLTFQILLFLLCFFLFLFPFFPLSLLFPSFFSTIMENYFSFFFTSNFSCLFVPSFFFLSFFLSGFFFFFPSFLFFHSFFLFSFFLFSYILPPFVTLLMLSFFLFSFFLIFISHFSLFVLYCFTYSFLSYFLSFLFSFFLSFFLILFHIFLYFFLTASLISFFLSFFLSFFLFPPKQIRMLGEMLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B1R6</accession>
    <name>A0A812B1R6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_8695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000283">
        <property type="protein sequence ID" value="CAE1166040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B1R6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1166040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="233" mass="27745" checksum="29FDD46964C59AAE" modified="2021-09-29" version="1">MYKLPHYQNLTVKKFSLVSFPSQYSFFHSFFLSLFLSFSLFISIYLAIYLSIYLFISIYLYVSSLFISPFLFTCSSIYLYHSVYIYLSIYLSIYLSMSFCSYLSIYLSIYLSIYLSIYLTPFCSNLPIDVILFNSIYLFHSDQTYLSIFFFLSLFLSSFQLSSVTNERIFCAFSKAEWHQRFFILTLPTQLSLYAMLTDNRLDKTYSRFSPSSFTSFFRKGYHQDRFLSKIHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B1T0</accession>
    <name>A0A812B1T0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DMRT4_5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SPHA_8476</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000274">
        <property type="protein sequence ID" value="CAE1165469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B1T0"/>
    <dbReference type="OrthoDB" id="6162476at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007548">
        <property type="term" value="P:sex differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1040.10:FF:000001">
        <property type="entry name" value="doublesex- and mab-3-related transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1040.10">
        <property type="entry name" value="DM DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001275">
        <property type="entry name" value="DM_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036407">
        <property type="entry name" value="DM_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026607">
        <property type="entry name" value="DMRT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12322">
        <property type="entry name" value="DOUBLESEX AND MAB-3 RELATED TRANSCRIPTION FACTOR DMRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12322:SF116">
        <property type="entry name" value="DOUBLESEX-MAB RELATED 99B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00751">
        <property type="entry name" value="DM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00301">
        <property type="entry name" value="DM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82927">
        <property type="entry name" value="Cysteine-rich DNA binding domain, (DM domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS40000">
        <property type="entry name" value="DM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50809">
        <property type="entry name" value="DM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="DM" evidence="7">
        <location>
            <begin position="53"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="DM" evidence="5">
        <location>
            <begin position="53"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAE1165469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="229" mass="24646" checksum="36C560A2755D819C" modified="2021-09-29" version="1">MSTSSDEERPRVAEVSSVVPSGTLVGAGGGSQQQHSTPIFIRAADRYPRTPKCARCRNHGVVSALKGHKRYCRWRDCVCAKCTLIAERQRVMAAQVALRRQQAQEENEARELGLLYGPNGLLTINPDSMPLFQGGAAPTNSAGSPGVTATTTTAGDVRAGGPGVSGQGGHITTVYSDNSNYNCDTAVNGASPVFVFFLSFSIYLSIYLSIYLSIYLSIYLSFQLRERVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B4K9</accession>
    <name>A0A812B4K9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_9731</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000312">
        <property type="protein sequence ID" value="CAE1167946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B4K9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="366"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1167946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="421" mass="51532" checksum="07FFD4ACBED7AB52" modified="2021-09-29" version="1">MRKSISFVCAAASVWLRAVKGRSYPTFFFYLIYTNCSSWQESVLVILGGRQQCTVCNIFLSHFFAYFLSFFFLSHSFSFFFRLPSLFRSFFFLSFFLSFFLSFFFSFIFLSFYFSFFSFLFLFFLHVSVLFFFLFLSFSFLYLSFSIFFFLLAVVKSGKQSTLFLSFFSHSFFSFSFLFSFSFFFFFLSSFIFISFSFFSFSFFFFILFPFFSPFFISFLLLSFFFLVSFFIFSFFFLFFLFSFFFHFYFFFFFFILFFLSFSFFFFLFSFSFFFFLFFSLFYFVPVTFIFLSFSFSFIFFFLSFSFSFFFSFFFVLLFSFFLLFNFVPSTFIFISFSSFSFYFFFLFPFLSFSFFFLSYSSFSFFIFLFYFVPVTFIFLSFSFSFFFLSFFLSLFLAVMKRVESIVNIEDIFHPLIGADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B4T3</accession>
    <name>A0A812B4T3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_10510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000339">
        <property type="protein sequence ID" value="CAE1169250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B4T3"/>
    <dbReference type="OrthoDB" id="1683831at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043379">
        <property type="entry name" value="ANKAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46464">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46464:SF2">
        <property type="entry name" value="ANKYRIN AND ARMADILLO REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="46"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1169250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="375" mass="42242" checksum="DCE5D7BAFD9D5263" modified="2021-09-29" version="1">MVNLTEMDENGWAQIHYAALNGYLLSVERFIEEDPELLEYETGDSKNSTPFLLAVTGGNKECVEFFIKKGAKIGVQNRFNQGPIEILLLNKNIELLQFFIDAKYPDLPVWRKLFRFLLSDSEEEAKNAAECLQMLTVYNSETGTNPNWELLRNEGGVVALVIVLTRIIPDEDQALTSATGIKILIDLLQHSKDDAILSLAADCVARLAHTRAGVPHAMISIDAVEYLCALLLSPLERVRGNAAIALSYLAIYHTAERQLLHKCRKEPILMKVLTYYSRDRKLPTGFQNGWKHYQRVGLPEIELSQLNLVNQQLKTTPQEMHIIELERDLIHHSSVDDIGNISNNCLTPMKEDISNAFSKRNSLQVPSENGSSFGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B6W5</accession>
    <name>A0A812B6W5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_11838</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000394">
        <property type="protein sequence ID" value="CAE1171951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B6W5"/>
    <dbReference type="OrthoDB" id="6162929at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40380:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40380">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032933091" evidence="2">
        <location>
            <begin position="19"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1171951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="185" mass="19844" checksum="4D7D550ED92E72C4" modified="2021-09-29" version="1">MSLVCITVGMSLVCITSGLHDCLSLVLHHCWNVLFASLLECLWFATVEMSGFCITVGMSVCITVRMSLVCITVGMSLVCITVRMSLVCMTVEMSLVCITVGMSLVCITVGMSLVCITVEMSLVCMTVEMSLVCITVGMSLVCITVRMSLVCITVGMSLVCITVRMSLVCMTVEMSLVCITVGNHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B720</accession>
    <name>A0A812B720_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_11250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000372">
        <property type="protein sequence ID" value="CAE1170893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B720"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="343"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="405"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1170893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="439" mass="50609" checksum="19795ACBF1CEC35B" modified="2021-09-29" version="1">MVTTVTEFCYFVECNDMTDDVPKRSFTILNNSSRHFNLRAQNTNNVFLERNILRIHMSLSHRRAVASLSLSLSLSLSLSLSLSLSVFLTNTFMFFLTLSFSQIPSLSHSCSSRLLFLQFPSFLPPTQLFFLYLLPVATTYSLYNLLFNFPLYLIPVVYPHSPFLHFLFSYFPFTIFRLLSSSLSITLSYNLLFSPLTLLFHLYLNSVVHPYSPFLSPPSLCYSRNLPLLSIQSLNFPLTLLFQLYLIPIVLPCSPFLNSPLYPLLVVLSYSLCNLISSSAYSPLPSLSHSLPPYSLYNLIFFFRFLSPSLSITFRSFLLLSLQSSIFFRLLCSSNFISFQKYFLTLLFPTLAVPPYSLYNLIFFFRFLSPSLSITFRSFLLLSLQSSIFFRLLCSSNFISFQKYFLTLLFPTLVVPPYSLYNLIFFFRFLSPSLSITSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B7J1</accession>
    <name>A0A812B7J1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SLC22A4_5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SPHA_11637</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000385">
        <property type="protein sequence ID" value="CAE1171572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B7J1"/>
    <dbReference type="OrthoDB" id="5141738at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17317">
        <property type="entry name" value="MFS_SLC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="295"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="380"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="438"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="134"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAE1171572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="583" mass="64858" checksum="E9C3D8E49B50E51E" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BB33</accession>
    <name>A0A812BB33_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Choline transporter-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SPHA_12967</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Farmed</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Choline transporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CTL (choline transporter-like) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000434">
        <property type="protein sequence ID" value="CAE1174119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BB33"/>
    <dbReference type="OrthoDB" id="420519at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007603">
        <property type="entry name" value="Choline_transptr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE (SLC FAMILY 44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385:SF12">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04515">
        <property type="entry name" value="Choline_transpo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="328"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="376"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="534"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="561"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAE1174119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="648" mass="73119" checksum="9D18EE1858FF92AA" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BDW0</accession>
    <name>A0A812BDW0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_14952</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000515">
        <property type="protein sequence ID" value="CAE1177972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BDW0"/>
    <dbReference type="OrthoDB" id="6819399at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1177972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="202" mass="23733" checksum="BC78B5CB88506F48" modified="2021-09-29" version="1">MKISRTFIISIYLSINSSLFIYIYFYLSISFCSSLSLSIYLSIYLSLSLSLPVYSIDIYLSIYLSIYLSLFNIYLSQSIHYLSIYLSIYFSLFILISVSSYLSINLSTCLSQSIHLSIYLSQFITYLFMSFCLYLSIYQVSPPSLSLSIYLYLSLFISISICLYLPLYISTSLCYLSIYLSIYCYGTFFIRFFYHRDFPFHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BE23</accession>
    <name>A0A812BE23_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_16658</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000590">
        <property type="protein sequence ID" value="CAE1228011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BE23"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1228011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="311" mass="34102" checksum="750DC2209154DDE4" modified="2021-09-29" version="1">MLRIPCRNRLSLDKCSPVFLSLFVSLSVSLSLSLSVCLSLSLSQSIFVSLRQKYTHAQIHKSSSFPFSPTLSLCLSLPVSIFLYLPSSLSLSLSLSLSLAPSVNICLSQINRKISLSIYLPICLSFFPLHLCFHVSVTLSVCISLPLYLTPCLFVCLSLSLSLSFFSPSISLSFHLSLCLSLSLSLSLFCLSLSLSVYHPFLSFFSISFSLFLSVIPSLSSVSLSLSNSLFSISLSLSFHFSTCHSLLLSLSLSLSVSRYLSVSMSFSASLSLCFFLSHPYIHTTQTHMFIGECFCSGIFSDRGVHKVLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BH53</accession>
    <name>A0A812BH53_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_18485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000668">
        <property type="protein sequence ID" value="CAE1232338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BH53"/>
    <dbReference type="OrthoDB" id="411632at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011735">
        <property type="entry name" value="WlaTC/HtrL_glycosyltransf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09612">
        <property type="entry name" value="HtrL_YibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1232338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="233" mass="27665" checksum="19CA45B87734C763" modified="2021-09-29" version="1">MAYKEDKREKVELTEKNKPQSNTQRDNITLVTAYFLLPPFRKGKKSIIAKIFKQPNYPVHYPNTVIPEYNCVSHAKFELLKWSIEQNYYHTKYFIWIDIGYFRMRVQNTFGLSLPPDFDERKVVLSQVEDVQNFLTLEEIVQYNLNWVAGGAILGRYDVLRKFCLKYLLFIKQSLEMGIIGAEQQMLYAMYSDSYRMRKEDIQICSEGWFCLGHLAVATWLQERNSNKLRRNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BK65</accession>
    <name>A0A812BK65_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_19164</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000695">
        <property type="protein sequence ID" value="CAE1233935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BK65"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="503"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="544"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1233935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="566" mass="64508" checksum="7C0B771F7A61408C" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BN68</accession>
    <name>A0A812BN68_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SPHA_19718</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000716">
        <property type="protein sequence ID" value="CAE1235275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BN68"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="188"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="321"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="379"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="410"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="444"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="471"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="501"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="544"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="571"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="603"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="634"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="659"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="698"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="730"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="762"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="793"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="826"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="858"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="676"/>
            <end position="882"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAE1235275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="882" mass="105550" checksum="2CD7EFF65A5322DE" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BP78</accession>
    <name>A0A812BP78_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_24262</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000904">
        <property type="protein sequence ID" value="CAE1244371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BP78"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1244371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="175" mass="20322" checksum="EEB518CDE0343FCF" modified="2021-09-29" version="1">MRLPQSGIFHEGRVHILLAGKGKDDVKEQVINNELFRLRMDIAAVQETCGFHSRESFMRERVHFLLAGKGKNDVKEQVINNELFRLRMDIAAVQETCGFHSRESFMRERVHFLLAGKGNDDVKEQVINNELFRLRMDIAALQETRGFHSRESFMRERVHILLAGKQEGRCQRASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BQY8</accession>
    <name>A0A812BQY8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_21307</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000780">
        <property type="protein sequence ID" value="CAE1238387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BQY8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="332"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1238387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="414" mass="47948" checksum="498A7BEE90F3CDB8" modified="2021-09-29" version="1">MKNLWRAPLQDSDLRHHLSINLSILLFLYLSIYLSIYLSIYLSILLFLYLSIYLSDCLSLYVSVCQKAYFFSLSLSVRIDIWEKAHYLGVFLSIYLSIYLSIYSYLSIYLSIYLSIYLSQSVRICVSKSLFFYSLFFSLSFSLSSYKSLIHNRFLSIYLSIYLSIYLSQSVSINLNLLFSYISEFLGRFFFSLSLCFYLSIYLSIYLSIYLSQSVSINLNLLFSYISEFLGRFSLSLSLSDILPKYTYIHTYLSIYLSIYLSIYLSIYLSIYLSIYARQPTTTIARNDVIISDTKQSPSIVCLFSVTYIAFLVFASPVITNLSFSSLNTCSVLFGICFDFSISVPFLIFFTFVFVAFLLDCLSRFEVNAPASAHELFEYLTYTESAIFHPVPKFIINAFSYTYLSIYLSITINI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BRI8</accession>
    <name>A0A812BRI8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_25547</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000967">
        <property type="protein sequence ID" value="CAE1247197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BRI8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1247197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="324" mass="38136" checksum="F6697468DC312132" modified="2021-09-29" version="1">MLRRARKYLSIYLSIYLSIYIYIYALYAREFFFILLCFYSAIFFFSYRFSPFYSALFFILLFFFFYSALLFFYSSRFFHSTFLFLFSFRSSLFFFILLIFSFHPFLFCYSRSAHLFFHSAHFSFRSSLFFFLLVFSFFFSFRSSPFLFCSFFHSALFYSAILSHSSGLPSSDFASFLFSVVFLFLLLKTVTQQLLQIGIRQANKCAKSIVWHLGFLFGSKCSFPPLRQSHPHHVSKTGSHRIFLPALSLSFFFFAPSFSTKPPSSRSSCSFSCLTLPFFFFLSYRSLSSSFSRTSFSYIASTYFLFFFPLLLPPNLFSSSIALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BTC4</accession>
    <name>A0A812BTC4_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SPHA_22368</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000826">
        <property type="protein sequence ID" value="CAE1240529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BTC4"/>
    <dbReference type="OrthoDB" id="6581954at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005283">
        <property type="term" value="F:amino acid:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089718">
        <property type="term" value="P:amino acid import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF321">
        <property type="entry name" value="SODIUM-DEPENDENT NUTRIENT AMINO ACID TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00610">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0915">Sodium</keyword>
    <keyword evidence="9" id="KW-0769">Symport</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="6"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAE1240529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="279" mass="32005" checksum="D61D7BC106A6A73C" modified="2021-09-29" version="1">MLSCLGYVIGLGNVWRFPYLVHRNGGGAFFIPYIIMLVFCGIPLAYMELAYGQYGSLGPITVWKAVPFFKGISFLILCLYLLFLSLIPSNMMKIINFFFSSSLSIFSFSPYFLPLLFLILCLYLILSLIPSNMMKIINFFFSSLSLPVLISFFACINFSLSHSLPLFSHSLPVSSLSLPYPFQYDEDYQFSSTLALLSFFASLLSFFAYPLPYPFQYDEDYQFSSTLALLSFFASLLSFFHLSLANMMYFLLFFSHFFACIFSFSPYSNMMKIINFLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BWZ8</accession>
    <name>A0A812BWZ8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">COL6A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_28430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001113">
        <property type="protein sequence ID" value="CAE1253428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BWZ8"/>
    <dbReference type="OrthoDB" id="687730at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01450">
        <property type="entry name" value="vWFA_subfamily_ECM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050525">
        <property type="entry name" value="ECM_Assembly_Org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020:SF20">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032538844" evidence="1">
        <location>
            <begin position="20"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="35"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="234"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1253428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="413" mass="46670" checksum="FDC7A0242B47B51F" modified="2021-09-29" version="1">MKIETNIILVLLGLSLVTAFSAEPETYYCGGKPADVYFLLDSSTSIWYVDYEKQLQFVSSVIDIFDVGPNRTRIGMGLFSDYFNPQIGFGDYNNKTEINQVILETKQKMGGTNTAVAIREMREGEFNSNVARQDVAHIAIILTDGKSWDPKETAFQAKLTKEKGIYIFAIGIGGDVDTRELRNIASKSENDNAQFVFHVKNFDALDSIKNILAIKTCEVVPKDQPRCATSTKSDIIFALDPLVMGQSRTEIIKEFIANTANQIDMGDSKPIRIGVFTNNCPSSKDIHLNEHGNKFTFIQELRSNNKMTKTHILKRVRRRGFTKANGGRADARRLIVTFVDGPLDNSKDVFLEAERVRKFNMDVFVIAIGNEVKENELRKLASVRPKEHIFRVTSYDNLKISFNDFIDKICEFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BXL2</accession>
    <name>A0A812BXL2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_25997</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000990">
        <property type="protein sequence ID" value="CAE1248104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BXL2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="503"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1248104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="532" mass="57793" checksum="FF364A76D0DDB3FD" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BXP1</accession>
    <name>A0A812BXP1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_25452</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000964">
        <property type="protein sequence ID" value="CAE1247074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BXP1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1247074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="220" mass="25031" checksum="8FD78FDE8ED49BB2" modified="2021-09-29" version="1">MRSVGAVCAGISRLVFILIEQGIHNDTLAVAGYINDGKQRKSAVSLPPSLFNCTGVCLRRTSIYLSIYLSIYLSIYLSIYLSQSVHIYLSIYQSVHLSMYHIYLSIYLSIYLSQSVHIYLSHLFISIYLSISICSLSIYLSIYLSTYLSIYLSIYLPIYLIQFVHIYLPTYLSQSVDIYLSIYLSIYLSISVCSYLSISLSLFISISLSLFISTYLSEML</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BYZ1</accession>
    <name>A0A812BYZ1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_24290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000905">
        <property type="protein sequence ID" value="CAE1244436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BYZ1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1244436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="205" mass="25348" checksum="FD8BA1A65724FAB6" modified="2021-09-29" version="1">MNQTDGFTKNGHAPPPTESRKSYRSHFFFHFTEIIYPLSSFLFFFVRFFLSFFSFFFFLFLSFFFCLFLSFFLFLFFLFLSFFFCLFLSFFLFLFCLFLSFFFCLFLSFFLFLFCLFLSFFFCLFLSFFLFLFCLFLSFFFLSFFFCLFLSFFLSFSFFLSFSFFLSLSFLFFLSFFFSLFLCFSFFLTLFLLCLFLSFFLSIFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C1F5</accession>
    <name>A0A812C1F5_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">U3 small nucleolar ribonucleoprotein protein MPP10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SPHA_28063</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Farmed</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in nucleolar processing of pre-18S ribosomal RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
            <location evidence="1 7">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the MPP10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001105">
        <property type="protein sequence ID" value="CAE1252641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C1F5"/>
    <dbReference type="OrthoDB" id="445326at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034457">
        <property type="term" value="C:Mpp10 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005732">
        <property type="term" value="C:sno(s)RNA-containing ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012173">
        <property type="entry name" value="Mpp10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17039">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN MPP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17039:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN MPP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04006">
        <property type="entry name" value="Mpp10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017300">
        <property type="entry name" value="snoRNP_Mpp10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3 7" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="101"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="156"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="239"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="550"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="610"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="159"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="169"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="186"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="201"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="248"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="266"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="622"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR017300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAE1252641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="633" mass="72735" checksum="25E7FBBE856990CA" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C659</accession>
    <name>A0A812C659_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Probable arginine--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="2">6.1.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SPHA_29029</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Farmed</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the attachment of arginine to tRNA(Arg) in a two-step reaction: arginine is first activated by ATP to form Arg-AMP and then transferred to the acceptor end of tRNA(Arg).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Arg) + L-arginine + ATP = L-arginyl-tRNA(Arg) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20301"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.19" evidence="2"/>
    <dbReference type="EMBL" id="CAHIKZ030001147">
        <property type="protein sequence ID" value="CAE1254519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C659"/>
    <dbReference type="OrthoDB" id="68056at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07956">
        <property type="entry name" value="Anticodon_Ia_Arg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000006">
        <property type="entry name" value="Arginyl-tRNA synthetase 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956:SF11">
        <property type="entry name" value="ARGININE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="ARGINYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00750">
        <property type="entry name" value="tRNA-synt_1d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DALR anticodon binding" evidence="12">
        <location>
            <begin position="147"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAE1254519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="262" mass="30339" checksum="1EE9C7C582357511" modified="2021-09-29" version="1">MEYSYCDLCAAKDRKEKYNFHKIHYVVDNGQKIHFANLKAVLAKMKESWVLRTGPHFHIGFGRVLGMSTRKGEVVFMKDILDEAQSIMLQKRRETRTTKDVHDEDAVADILGISSILVQDLKERRNRDYKFNWEKCLNFKADSGVFLQYAHARLNSLQLTCGTQLSNQVDYSLLQEQDAFKLVLHICRYDEVLRDTMQTFEPCIVVQYLFQLAHLSNQAHHELLVKGQPEELAQARLLLFHCTQQVLANGLRLVGVPPLDKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C7G4</accession>
    <name>A0A812C7G4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_29122</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001155">
        <property type="protein sequence ID" value="CAE1254696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C7G4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="307"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1254696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="332" mass="37755" checksum="2EA6BE5549718A55" modified="2021-09-29" version="1">MRPHLTTRSRDHILTSLSRLGCLCWHVFFGLSLLSCLFWPVSFSLSLLGRLIWPISFGSSVLACLFWSVSFGLFLLGCLFWAVSFGLFLFVCFFWAVSFGISLLALLFWLVSFGLFLLGCLFWLSLLACFFGCFFWAVSFGLSLLVCFFWAVPFGLLLLACFFGSVSSGLSLLGCLFWAVSFGLSLLACLCLSASFELKLDTKVYLKSVNIYLSIYLSIYLSIYLSAHTYLSFSYLSIYLSIYLSIYLSIYLSISSLLISIYLSICSYLYQFFISIYLSISSLLISIYLSIYLSIYLSAHTYLSFSYLSIYLSIYLSIYLSLFISIYLNLFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C8D1</accession>
    <name>A0A812C8D1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SPHA_33137</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001387">
        <property type="protein sequence ID" value="CAE1262284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C8D1"/>
    <dbReference type="OrthoDB" id="2373987at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034703">
        <property type="term" value="C:cation channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070679">
        <property type="term" value="F:inositol 1,4,5 trisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015279">
        <property type="term" value="F:store-operated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051480">
        <property type="term" value="P:regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002153">
        <property type="entry name" value="TRPC_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10117">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10117:SF54">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL-GAMMA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0407">Ion channel</keyword>
    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="130"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAE1262284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="295" mass="34417" checksum="B040B1BB0659CB67" modified="2021-09-29" version="1">MPLNSLNIEFHLQTEYYALITKLDNFVVKLLNHIYTQAELELIINKVGKSNEEKYENLGRLKLAIRYQKKQFVVHPAIQQRLVYTWYAGKPLLEHSGLFQKLCGMLLVLIFYPVLLVAHLVRPKSQMGKILVYPCIKFMCHILSFIVFLSLIAISSLNQEKYLGQRFSEVLPDIYDQYVTFRNASKMDFFGQDFPLRKSSINEVEKDKSTKYLRQNLNSSAHFDEFLYQIYWLNADRYYWDMYDPDNISDATHALANILTFARISYVLPASSTLGPLQISLGRMIKVNDKLFPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CA21</accession>
    <name>A0A812CA21_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA-directed primase/polymerase protein</fullName>
            <ecNumber evidence="6">2.7.7.102</ecNumber>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SPHA_32207</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Farmed</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:22509"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ssDNA + n NTP = ssDNA/pppN(pN)n-1 hybrid + (n-1) diphosphate.</text>
            <dbReference type="EC" id="2.7.7.102"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic-type primase small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.102" evidence="6"/>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="EMBL" id="CAHIKZ030001335">
        <property type="protein sequence ID" value="CAE1260392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CA21"/>
    <dbReference type="OrthoDB" id="5988181at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006264">
        <property type="term" value="P:mitochondrial DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009411">
        <property type="term" value="P:response to UV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044917">
        <property type="entry name" value="PRIMPOL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31399">
        <property type="entry name" value="DNA-DIRECTED PRIMASE / POLYMERASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31399:SF0">
        <property type="entry name" value="DNA-DIRECTED PRIMASE_POLYMERASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03121">
        <property type="entry name" value="Herpes_UL52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAE1260392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="549" mass="64424" checksum="7BD5421E5C8CD3BA" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CAD1</accession>
    <name>A0A812CAD1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_33123</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001387">
        <property type="protein sequence ID" value="CAE1262285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CAD1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1262285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="214" mass="24854" checksum="9F8335D5002EE47F" modified="2021-09-29" version="1">MRHLPATGKSWRNRYGTNGGKGGNGRRDEDSKRRRNRAWLVRWKEARNFPRNRFRRDRCPPTRVPTTRERPGLLGSCFKTGQVGCRCTSRTRVDGRHSQTPTYRAGKYYFPRAQILRPDAEKTSRRDDITHRRGNRRGPVSFKSSREHCPSRARDGGGSLRARDPRRGSSDEKKLVRHVYRIAFSFPRSPAEGGQYASNHATTVLSFYYIYRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CCI9</accession>
    <name>A0A812CCI9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_32310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001339">
        <property type="protein sequence ID" value="CAE1260616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CCI9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1260616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="253" mass="29908" checksum="F9DAD4EED312837B" modified="2021-09-29" version="1">MIYCHPSKSIYLSISFIHLSIIYPSQFIIHPSIYLSIHPYLSIHLHPSSIYLSFLHLSHHNCLDLFKKSFILINHYHLSIYLFINLSIYLSIYHLLNLSIYLLIYLSGIFIFLFIFLIYVFIYLFFFALLSLFCLSICLLKTSLLTTKTRARRIFIKNLIIVPSSFLKFCLICHISIIYLSIYRKILSFRNRSFLLSFVEIFFQSIIYLSMSTIDIILSSIYLSIYVSLLISIYLSILYQFIDIHSFIGLSIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CF03</accession>
    <name>A0A812CF03_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">H/ACA ribonucleoprotein complex non-core subunit NAF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SPHA_33629</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001412">
        <property type="protein sequence ID" value="CAE1263240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CF03"/>
    <dbReference type="OrthoDB" id="21550at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005732">
        <property type="term" value="C:sno(s)RNA-containing ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000493">
        <property type="term" value="P:box H/ACA snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.230">
        <property type="entry name" value="Probable tRNA pseudouridine synthase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038664">
        <property type="entry name" value="Gar1/Naf1_Cbf5-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007504">
        <property type="entry name" value="H/ACA_rnp_Gar1/Naf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040309">
        <property type="entry name" value="Naf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31633">
        <property type="entry name" value="H/ACA RIBONUCLEOPROTEIN COMPLEX NON-CORE SUBUNIT NAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31633:SF1">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX NON-CORE SUBUNIT NAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04410">
        <property type="entry name" value="Gar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="542"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="574"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="604"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="637"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="664"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="695"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="89"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="366"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="461"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="148"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="176"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="216"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="423"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="461"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="479"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAE1263240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="725" mass="82297" checksum="CF5EEC67F165449B" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CFH1</accession>
    <name>A0A812CFH1_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA mismatch repair protein MSH3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4 12">DNA mismatch repair protein MSH3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">MutS protein homolog 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SPHA_38201</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA mismatch repair MutS family. MSH3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001729">
        <property type="protein sequence ID" value="CAE1273496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CFH1"/>
    <dbReference type="OrthoDB" id="10252754at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.110:FF:000010">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.10:FF:000004">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1420.10:FF:000004">
        <property type="entry name" value="DNA mismatch repair protein Msh3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017261">
        <property type="entry name" value="DNA_mismatch_repair_MutS/MSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF122">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037677">
        <property type="entry name" value="DNA_mis_repair_Msh6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="DNA repair protein MutS, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein MutS core" evidence="15">
        <location>
            <begin position="353"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="510"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00073774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAE1273496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="658" mass="74745" checksum="0B6E3C825D7EB333" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CGG8</accession>
    <name>A0A812CGG8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_35295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001513">
        <property type="protein sequence ID" value="CAE1266677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CGG8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1266677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="243" mass="29087" checksum="227242E295B5C2E7" modified="2021-09-29" version="1">MTSFSPPSSHLLSFFLSFFFLSFFFLYMLSFFLPYFFMTSFSPPSSPPSFFLSFFLSFFLSFFDFPSCFFFFFFIFYFHIFIIYGFFIFPISAKIFFFLSFFLSFFLHLTLFSLLFSFFFFFVFLSFLFSSPFISLFLFVVLLSPTRAQQSFFFSFLFSFYLLLSFFSFLPNIFPFFVFYPLLSFVFLSFFSIFFSLHPSLSLSLSLSLSLSLFLLLSRSLSPLHHSTQYTHAFGPFHRMIFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CGI5</accession>
    <name>A0A812CGI5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_34314</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001452">
        <property type="protein sequence ID" value="CAE1264662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CGI5"/>
    <dbReference type="OrthoDB" id="437960at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.110.10">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003409">
        <property type="entry name" value="MORN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052849">
        <property type="entry name" value="MORN_repeat_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46917">
        <property type="entry name" value="MORN REPEAT-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46917:SF1">
        <property type="entry name" value="MORN REPEAT-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02493">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00698">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82185">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1264662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="156" mass="17625" checksum="DA0C59A6CA4EDF7A" modified="2021-09-29" version="1">MATQMAAIKKKLHFQFQEKDVDENSMAFEDVYIFPSGDKYEGQILRTKKGGLERSGFGKQVAINGTIYEGQWLNDAMNGHGCLSHSSGDCYEGQFLDNQFHGIGTYTWANGAYLHGNFEHNRLEGKGVFTDTMNQIWEGHFSHKLATGLMFKLNMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CGJ7</accession>
    <name>A0A812CGJ7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_38807</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001780">
        <property type="protein sequence ID" value="CAE1274344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CGJ7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="274"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1274344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="298" mass="36081" checksum="ABFAD3FFF058090C" modified="2021-09-29" version="1">MVEWHSINQTSPADLAYKKYLSLFFQTPFHRQFFFRLLSRVDFDFLKLFTPYFFYIFFLFKKLILPFSHKSFPFFLSIFLSRVITTFSTSFLSFLLPVPLSSNLSPPLCLSIYFSLYTTTSRQPVAVIYTPFRDCRFRWYCFSFFHFFIHLSFFLSFFLSFFLSFFFLSFFLSFFLFSRTLPISFLFSHFFFLSLSYPVSPSPLCHTSTNFSLAFHHTIYLFFLFLFFLFLFFFLSVDVFLFLYLPLSLFFHWPLPLSLLTTSLFLLPSYVLQFIFLPSFLHLFYFFYFPIFVTSIYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CGK1</accession>
    <name>A0A812CGK1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_33767</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001420">
        <property type="protein sequence ID" value="CAE1263579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CGK1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1263579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="270" mass="30206" checksum="6BC077CC29EADAB8" modified="2021-09-29" version="1">MYPLSFSSSFPSSLFSTTISLLPPTPSLSTSIPVPPTPPPALLPPSSSVLSSFSNFFFLLLLLFLLLLLLQATSSSLHSPAPSSFLSATLSLPPPASFSSTIPAHPTSVLLLSFSFFCSFLLLFIYSSNFPSFFYTCFSSSSSSLFFLCSFFLFYDYFFSSSNFPSFYSYCYSCCCSSTSCYSSLLIRILTFLTAIYIYLSIYLSIYLSIYLSLFLSLNLFLSIYLSIYLSIYLSIYLSMFISVSGCFHLSIYLSIYLSERTMRFIIQCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CIR0</accession>
    <name>A0A812CIR0_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heme-copper oxidase subunit III family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_36771</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001614">
        <property type="protein sequence ID" value="CAE1269831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CIR0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000298">
        <property type="entry name" value="Cyt_c_oxidase-like_su3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50253">
        <property type="entry name" value="COX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="295"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="323"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="388"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="421"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="451"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="483"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="559"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="585"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="612"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="639"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="674"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="705"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="737"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="domain" description="Heme-copper oxidase subunit III family profile" evidence="2">
        <location>
            <begin position="293"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1269831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="766" mass="95570" checksum="4C2957C802A59BD0" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CK85</accession>
    <name>A0A812CK85_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_35236</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001513">
        <property type="protein sequence ID" value="CAE1266558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CK85"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1266558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="218" mass="25147" checksum="246AA5BF279FA7AE" modified="2021-09-29" version="1">MESFIVGHLYLCLATPPPHGSLDSILFIALCSRENSSSPPYSIPGNSIPWLYCLACGKIYLSIYLSIYLSIYHIVHIYLSIYLSIYLSIYLSHCFYLSITLFLSIYLFISIYLSIYLSIYDIVHIYLSIYLSIYLSHSETPWCHIPQMVLSNPRYPGNKTSHSTTTFSVALTVCLIFLIIMHQANIKRYYVNEDFSGEFMEKKVFIIANKHLNLKNDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CK92</accession>
    <name>A0A812CK92_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_36917</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001628">
        <property type="protein sequence ID" value="CAE1270125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CK92"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1270125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="201" mass="23235" checksum="F92659C187776315" modified="2021-09-29" version="1">MGIVWIHSRQIYLSIYLSIYLSIYLSIYLSCVSFRFTKSYLLRPPLHSSLLICIRHLTGGNIQKTSSPTPSHSCRQQMPTIFKETSSPTPSHSCRQQMPTIFKETSSPTPSHSCRQQMPTIFKETSSPTPSHSCRQQMPTIFKETSSPTPSHSCRQQMPTIFKETSLTTPSRFQSYVFWFLSIYLSIYLSIYLSIYLYIYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CKW5</accession>
    <name>A0A812CKW5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_36512</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001599">
        <property type="protein sequence ID" value="CAE1269317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CKW5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="301"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="324"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="399"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="428"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="455"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="484"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="511"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="546"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1269317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="588" mass="67710" checksum="6484FB0BFACA4613" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CNG7</accession>
    <name>A0A812CNG7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_42104</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002041">
        <property type="protein sequence ID" value="CAE1280049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CNG7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="375"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="443"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="471"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="501"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="530"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1280049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="583" mass="68482" checksum="E9E255C1D7DB4828" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CTI3</accession>
    <name>A0A812CTI3_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Translocation protein SEC62</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SPHA_43158</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SEC62 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002149">
        <property type="protein sequence ID" value="CAE1281969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CTI3"/>
    <dbReference type="OrthoDB" id="200187at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031204">
        <property type="term" value="P:post-translational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004728">
        <property type="entry name" value="Sec62"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12443">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12443:SF9">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03839">
        <property type="entry name" value="Sec62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="223"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="102"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="289"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="343"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="123"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="366"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="381"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="406"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAE1281969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="416" mass="47207" checksum="2A9E4D4E8D27B703" modified="2021-09-29" version="1">MAEKRKSRRKQDEEKETPTKEEYAVARHLRFNSPVKEGRLAGITVTCFIGCKAVDVLMHSKWSSTENKTNPLFTNRQSCVNYLDRLLVKGLFHRAIRIEKKKSEKTKPKKKIKAGSEEETNLEEEKKSKKDKKSKKEKESDREGEKTDDTEKKKDEKEEKKEEDKKKKEKKLKLGMPDDQRFIDGVCLVFDPVPLKTFIIGLLMVLGAIALCLFPLWPEEVRLGVYYLSLSGAVFLAFILVLFVVRLVLFCLIWMCTLGKHHFWFLPNLNEDVGFIDSFLPLYKHETYSPKPKDSDRKGKGSDKDDIEATKSSGANNSNGENLCSSDSKAITEVTTAEEMARTGINMDEEKAQGEQSGGGGGTESEPSDDQEGFELVDKEDLTEDDDDDDDDDDEDEDEADDDDGDRGQSETKKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CTL6</accession>
    <name>A0A812CTL6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_41812</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002021">
        <property type="protein sequence ID" value="CAE1279499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CTL6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1279499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="199" mass="26211" checksum="08820BD039A8D426" modified="2021-09-29" version="1">MFLFFLSKIFFLLVIFFLSFIFNIFWIFFQIFFFIFSFFFISLFFFFSFRKFHFFNFFYFFLFFFFSFFFSSHYSFFLPFLLCLSSFSFLSFLFIFFFSFIFQQFFFFFFSSFFFKIFFFFLLEFFFLLFLFFFFFIFFIFFFLFFSFFFFIFFFFFIFFLFFLLFFSLFKLIHFSLSFFYIFFFYFFLSFFFHNFFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CUS5</accession>
    <name>A0A812CUS5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_40299</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001902">
        <property type="protein sequence ID" value="CAE1276901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CUS5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="281"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1276901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="380" mass="43302" checksum="997CCE7BEFD98908" modified="2021-09-29" version="1">MIIRVSFYFLVDFLCLPSFFFIFLLPSPLSTSITTTPTPSPTRPYTSRPNRFLARCLCATKQNQPINRFTTKHQLSGIPTIFNYLLILSLFHPFSTLFYHFLLLFLLFSTLSTYFCVSSHFLLSPHPSAFPPIFYSLLILLLFLLFSTLSTYFCVSSHFLLSPHPSAFPPIFYSLLILPLFLPFSTLSSSFRFFSHFLLSPHTSAFSPIFNSFLIFLIFLLFSTLSIYFCFSSHFLLFPHPSAFPPIFYSLHLLLLFLPFPPPSHSSAFSSIVYSPPYPSVFPPIFYSLLILLLFLLFPPLSSSTRFSSHCLLSPFFLVFADPHQISACCGMRLIERKSQIYIPSKRPNILLSTLAVAEGGSLESFRIRTTLTDSNSHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CW32</accession>
    <name>A0A812CW32_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_44264</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002255">
        <property type="protein sequence ID" value="CAE1283790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5917269at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1283790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1602" mass="179353" checksum="08B7DC01AA610D0B" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D1B4</accession>
    <name>A0A812D1B4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zinc finger protein 474</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SPHA_43455</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002183">
        <property type="protein sequence ID" value="CAE1282426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D1B4"/>
    <dbReference type="OrthoDB" id="265955at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026319">
        <property type="entry name" value="ZC2HC1A/B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049899">
        <property type="entry name" value="Znf_C2HC_C3H"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13555">
        <property type="entry name" value="C2H2 ZINC FINGER CGI-62-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13555:SF66">
        <property type="entry name" value="ZINC FINGER PROTEIN 474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13913">
        <property type="entry name" value="zf-C2HC_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52027">
        <property type="entry name" value="ZF_C2HC_C3H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="C2HC/C3H-type" evidence="7">
        <location>
            <begin position="53"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="C2HC/C3H-type" evidence="7">
        <location>
            <begin position="164"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS52027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAE1282426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="318" mass="37094" checksum="04DFCCC9FC6481CD" modified="2021-09-29" version="1">MTVHLTTCKQKKQNSNVKTLLSSKKLLNSSSRSQILPLNKMEPVIAFQSSGPQFLTCHICGRGFGSHSLPIHEPQCLAKWKKENSNLPSNQQQPVLAKDKTFPAAQVKINERNHKRNEITQSCSNCAKLMSVSEFKDHQKNCKKQITPKVQKSVSAVSVFARPPTVICYICGREFGTKSIFIHEPQCLKKWHLENEKLAKKDRRPEPKKPEVVSLNGDGIYNLDAMNEVAWQVLTGLLFIRRVASQRKNELYSWCWMFLNPFICYFFLSFFILHIYFLPICLFFIFLHFTFLYIFFLSLQFSLFYFYVFPFIFYFFCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D2M1</accession>
    <name>A0A812D2M1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_45516</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002346">
        <property type="protein sequence ID" value="CAE1285560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D2M1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="440"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1285560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="472" mass="54374" checksum="5590094DF4E2DC2D" modified="2021-09-29" version="1">MFFFLSHLSAFYSLAGNGRIFYNENLGRTPQHYLSIYLSIYIYLSIYLFSFHLSFNLFLFQLLFLHLPSFHLPLSTSLSTSSFSNLSFQPTLPLSTSLSTSSFFPPLSTFSSFHLSLPPSILLSHLSINLSFNLFLLHPPLFFSSSFHISFTSTFPTLFLHLPYFHLFPSSLSTSSIFFPPLFLHPPFHLYQTTSSFHLSFYHILLLLFHLSFNHFLFPPLFLHLPLSTSLSTSSSFHISFYIFLFPHLFLHLPLSNSLSTSSYFHLSFYILLFPLLFLHLLFPTLSTSSYFSFYILPLFSIFLFSTYIFLFPTHLHLPLSHFQPLPLSTSLSTTSSFHLFLHPPLSTSLSTTSSFHLSFNLFLFPPLFLHLPLSTSLSISSSFHLSFNHFLFPPLFQPLPLSTSLSTSSSFHLSFYIFLFPPLFLHLPLSTSLSTSSSFHLSFYIFLFPPLFLHLPLSTSSSYHLSFYIFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D402</accession>
    <name>A0A812D402_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Sulfide:quinone oxidoreductase, mitochondrial</fullName>
            <ecNumber evidence="14">1.8.5.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Sulfide quinone oxidoreductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">SPHA_45649</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">Farmed</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the oxidation of hydrogen sulfide with the help of a quinone, such as ubiquinone-10, giving rise to thiosulfate and ultimately to sulfane (molecular sulfur) atoms. Requires an additional electron acceptor; can use sulfite, sulfide or cyanide (in vitro). It is believed the in vivo electron acceptor is glutathione.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol</text>
            <dbReference type="Rhea" id="RHEA:55156"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58905"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.8.5.8"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:55157"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ubiquinone-10 + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + ubiquinol-10</text>
            <dbReference type="Rhea" id="RHEA:62608"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:46245"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58905"/>
            <dbReference type="ChEBI" id="CHEBI:64183"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:62609"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ubiquinone-10 + hydrogen sulfide + sulfite + 2 H(+) = ubiquinol-10 + thiosulfate</text>
            <dbReference type="Rhea" id="RHEA:38359"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:33542"/>
            <dbReference type="ChEBI" id="CHEBI:46245"/>
            <dbReference type="ChEBI" id="CHEBI:64183"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:38360"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the SQRD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.5.8" evidence="14"/>
    <dbReference type="EMBL" id="CAHIKZ030002362">
        <property type="protein sequence ID" value="CAE1285857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D402"/>
    <dbReference type="OrthoDB" id="5376590at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106436">
        <property type="term" value="F:glutathione-dependent sulfide quinone oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070224">
        <property type="term" value="F:sulfide:quinone oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070221">
        <property type="term" value="P:sulfide oxidation, using sulfide:quinone oxidoreductase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000034">
        <property type="entry name" value="sulfide:quinone oxidoreductase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015904">
        <property type="entry name" value="Sulphide_quinone_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10632">
        <property type="entry name" value="SULFIDE:QUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10632:SF2">
        <property type="entry name" value="SULFIDE:QUINONE OXIDOREDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0874">Quinone</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="17">
        <location>
            <begin position="12"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00052986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00059167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00060891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00066447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00070160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00082958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CAE1285857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="421" mass="46979" checksum="FD80FA1C145175CA" modified="2021-09-29" version="1">MSSLQEKKDRSYKLVVVGGGSGGCSVASSFSRYLGKGHVAVIEPNQEHYYQPLWTLVGGGLKNVEQSKQPMVNVLPQNCDWIQDKVVTFDPEGCSVTTRNGSKISYEYLVVAMGLQLDFDKVTGLVDAIQSDPMVVCNYSVKTVSKTFPALQSFKRGKAIFTYPNTPIKCAGAAQKIMYLTDDFFRKNGKRDQSDIEYFTSLGMIFGVKYYAEKLEKIAAGRNINVNYLHNLIEVQADKREAIFAKINSEGGETVTVKYDLLHVTPPMSAPNVIKASPLTDTSGYVNVNKQTLQHVKYSNIFSLGDCTNIPTSKTAAAVACQSGILQNNLKAVMKGNSNQKMYDGYTSCPIVTSSNKCLLAEFDFDNQPLETFPFKQAKERSSMFFVKSYLLPFIYWNLMTKGYWRGPKFFRKLMHLGLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D4M6</accession>
    <name>A0A812D4M6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_47262</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002556">
        <property type="protein sequence ID" value="CAE1288720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D4M6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1288720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="202" mass="23644" checksum="2D5EFD01C2A8BDA7" modified="2021-09-29" version="1">MIYLVICITDHISLYILFCSYLSIYLSIYLSIYLSIYLSIYLNLCISIYLSIYLSIYLSIYLNLCISIYLSIYLSQSVYIYLSIYLSIYLSQSVHIYLSLACIYSSICQSILACSYLFIYIFLFHFISLCLVWSIYLSIYLSIYLSIYLSILFCLHNVTIYLSIYLSIYLSILSVHIYLSIYLSIYLSISLNHPTPDQSCKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D516</accession>
    <name>A0A812D516_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_46705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002483">
        <property type="protein sequence ID" value="CAE1287654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D516"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="290"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="357"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="386"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="411"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="489"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1287654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="517" mass="62521" checksum="E53AC47A4332907E" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D621</accession>
    <name>A0A812D621_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_45953</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002401">
        <property type="protein sequence ID" value="CAE1286333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D621"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1286333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="188" mass="22318" checksum="ACD32349BF844B56" modified="2021-09-29" version="1">MKYLQSKTETLNLSLSLSLSLSLSLSLSLSLSVSIYLSILLSLSLALSHGNFVQQVFSFSFHSYLSLSLPLSFSLSLSLSLKRSNDLNYFSFFTLFVFLFFHSFFLFFSFFFSFSFFFLFFFVVKRSNNLYFPVCCFFLFFLTFSFYFLSLFCFFLLFLSFFFLLICFSFFLSFFLLSFFLFFLSYKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D8Z3</accession>
    <name>A0A812D8Z3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_48069</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002655">
        <property type="protein sequence ID" value="CAE1290227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D8Z3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1290227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="228" mass="26829" checksum="FAE807356F2EB3F1" modified="2021-09-29" version="1">MLPVHSSPLSSVSHSLMSLNQMLDIFENSASIAYKECISASLTEARSFFHHCSFSFSLLLNISYSFSFHPQYFLLFSFILNISQYFFPSYSFFPSYSFFPSYSFFPSYSFFLYPQYFLLFFPSSSIFLSPFSILPQYFLLLFPSSSIFLTPFSFFLNISYSFFLLPQYFLLLFSFFLNISYSFFPSSSTFLTLFPSSLIFLTLFSFFLDISYSFFFFLDISYSFFLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D9R0</accession>
    <name>A0A812D9R0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_50071</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002922">
        <property type="protein sequence ID" value="CAE1293907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D9R0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134:SF22">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134">
        <property type="entry name" value="OS08G0543275 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="94"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1293907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="307" mass="35263" checksum="BDEF8B3FFF4064FC" modified="2021-09-29" version="1">MGWICSFLISIYLSIYLSIYLSIYLSQSVHIYESISVCSLSVYLSIYLSIYLSIYLSQSVHIHLSFFISIYLSIYLSIYLSIYLSISVCSYLCIYLSLFRSIYLSIYLSIYLSIPVCSYLSIYLSIYLSQSIHIYVSISVCSDLSIYLRLFTIYLSIYLSIYLSIYLSIYLSQSVHIHRSSSYLSILLPFLSLCLPHIFLIFIVFLLPLLFLSLFLLLLFSSSSSSSPSSSSSSSSSSPFLIFFFFFFFFLKDNAAYASLDLSIYLSIYLSIYLSIYLSISAYASLDLSIYLSIYLSICVYWNTPIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DAE8</accession>
    <name>A0A812DAE8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_49370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002816">
        <property type="protein sequence ID" value="CAE1292625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DAE8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="286"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="347"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="392"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="422"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="447"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="474"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="502"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="532"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1292625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="550" mass="63102" checksum="3D955FE70D69EB8A" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DAS2</accession>
    <name>A0A812DAS2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_51812</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003164">
        <property type="protein sequence ID" value="CAE1297075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DAS2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1297075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="228" mass="27304" checksum="2E1C8A03E8D6AC2D" modified="2021-09-29" version="1">MFSFISLDVNIFYAHTSLSVHYLSIYLSIYLSKSLFIYTLVIYLSIYLSIYLFQSFFLSIYLSIYLSTAACLYLSIYLSIYLSIYLSQSFFFFFLSISSIYLSIYLSIYLFTAVFFFIFFIYFLSIYLSIYLSIYLSIYLSQSLLSIYHSLFVFLAIYLSIYLSIYLSIYLSLSLSIYIYIYIYIYIYIYIYILVTLAVFSIYLSIYLSIYLSIYLCYDHFNHRYLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DCM3</accession>
    <name>A0A812DCM3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl-CoA-binding domain-containing protein 5,Acyl-CoA-binding domain-containing protein 5A,Acyl-CoA-binding domain-containing protein 5-B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SPHA_51223</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003087">
        <property type="protein sequence ID" value="CAE1296039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DCM3"/>
    <dbReference type="OrthoDB" id="71307at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00435">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.10:FF:000010">
        <property type="entry name" value="Acyl-CoA-binding domain-containing protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022408">
        <property type="entry name" value="Acyl-CoA-binding_prot_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310">
        <property type="entry name" value="ACYL-COA-BINDING PROTEIN, ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310:SF77">
        <property type="entry name" value="LD25952P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00689">
        <property type="entry name" value="ACOABINDINGP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00880">
        <property type="entry name" value="ACB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACB" evidence="3">
        <location>
            <begin position="18"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="199"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="413"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="233"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="295"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="437"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAE1296039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="605" mass="67294" checksum="CFD88B465EE0BCD6" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DDF7</accession>
    <name>A0A812DDF7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_51348</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003108">
        <property type="protein sequence ID" value="CAE1296283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DDF7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="321"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="351"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="386"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1296283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="410" mass="43865" checksum="CCF62E0A94D406E4" modified="2021-09-29" version="1">MAVTLFFFPFLLQALKEPAFLGKKHFYLGITDFFLNEEFLSLLFASSQHGYIVCIHKYILVIFFIFFVYPLYSLCPSCFSIFFSLSLSFSLSLSSLLPLSLSSLLPLSLSSLLPLSLSSLLPLSLSSLLPLSLSSSSVSILPSLCLYPHSSLCLYPHSSLCLYPHSSLCLYPHSSLCLYPHSSLCLSSPSLCLYPPPPSVSVLLLPLSLSSSSLCLSSSLPLSLSPLSLPLSLSSLLPLSLSSSPSVSVFTPPSVSVFTPPSVSVFTPPSVSVFTPPSVSVFTPPSVSVFTPPSVSSVSVFTLLSLSSLFCLCLHSSVSVFTLLSLSSLLCLCLHSSLCLCLHSSVSVFTLLSLSSLFCLCLHSSVSVFTLLSLSSLFCLCLHSSVSVFTLLSLSSLFCLCLHSSVIVLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DH32</accession>
    <name>A0A812DH32_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_51654</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003142">
        <property type="protein sequence ID" value="CAE1296799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DH32"/>
    <dbReference type="OrthoDB" id="10071239at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1296799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="265" mass="29846" checksum="0AEFC58CA63E7AA0" modified="2021-09-29" version="1">MTLRALADSKPHLARRSTQRPSVPLTSTVDGTTSVIPYTPQLFLRLGRRIVEMRPGTKFTGMRSSQPLKTRDLKAARSKAQQTARRCANDYWVNLCSRIQTAADSGNARGMYTSIKTATGSTPINTAPLRSKVGEVITDQGKQLEYWVKYYLELYTTRNVVRDAALDALPSLPVMKESDSPPSEVLKSGKPVLLRHLHELLCLCWEKDHVPRDMRDANIVTLYKNKGDRSDCNNYRGISRLSFVGKVFAHVVLPRLQNLVCILRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DIG4</accession>
    <name>A0A812DIG4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_52368</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003250">
        <property type="protein sequence ID" value="CAE1298006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DIG4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1298006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="177" mass="19411" checksum="0C0446A69DDE83A1" modified="2021-09-29" version="1">MMTEELQWKVCREGWVFFSFFPTSASGSLALNKALRYIPPPFLSLSLLLFHYSLSLSLLLSLSLLLSLSLSFSHKARFICAFRFVLNSIIFIPVTSLSFSLSLSLSLSLSFSFSLSLSLSLSLSFSLSFSLSLSLSFSLSLSLSLSIHLSIYLYLTVCLSSTLVASSLNLPLSIMGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DK21</accession>
    <name>A0A812DK21_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_54497</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003538">
        <property type="protein sequence ID" value="CAE1301594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DK21"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1301594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="315" mass="34864" checksum="9F6EEB2FA08EB76A" modified="2021-09-29" version="1">MRISAATPDLDKRCNYNPALTSYSPSFSSSSSSFFSYSYPSSFFFATASSFFFSFSSFFFSSSSTPLLLLDLLLLLLLHLLPLLLLLHLLFFFSFSAFFFFFFFSSSSSPPLLLLLLLLLSLLLLLLLLFLLLLLFLLFPTPSSSSLTPTLPSSPPPSPFSSSSSLSQLSSYSSSLPPPPQYFYSISFSISYSYSTVFSSPSFFSSSSSPSPPPSLSSFSSLPPPPPHFYFSFFSSSSSLLLSSSFLLLLALFFLLLLLLFFFFSSSSLLLSSSYLLLLALLFLHLLVLLLLILLLLLFLQIPLIFLLLLCVVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DN63</accession>
    <name>A0A812DN63_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PepM</fullName>
            <ecNumber evidence="2">5.4.2.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_59676</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isocitrate lyase/PEP mutase superfamily. PEP mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.9" evidence="2"/>
    <dbReference type="EMBL" id="CAHIKZ030004133">
        <property type="protein sequence ID" value="CAE1307658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DN63"/>
    <dbReference type="OrthoDB" id="429143at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050188">
        <property type="term" value="F:phosphoenolpyruvate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00377">
        <property type="entry name" value="ICL_PEPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039556">
        <property type="entry name" value="ICL/PEPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42905">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42905:SF7">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE PHOSPHOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13714">
        <property type="entry name" value="PEP_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1307658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="161" mass="18192" checksum="678C87B7F1CD4615" modified="2021-09-29" version="1">MTFKHFANTFVRKQYMNGISRMVLSHEFSCAAPGKICKTKQLKQMLESPKLEFIMEGHNGLSARIVQEAGFKGIWGSGLSISAQLGVRDSNEASWTQILDVMEYMSDATDIPILLDADTGYGNFNNARRLVRKLEERGVAGKLLFLFVLFFKRKFCLTITI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DR78</accession>
    <name>A0A812DR78_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_60693</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004230">
        <property type="protein sequence ID" value="CAE1308875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DR78"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1308875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="218" mass="25419" checksum="2B2637FDD5B37341" modified="2021-09-29" version="1">MFSPLLFSCTFLPFHYVRRRFLSLSLSKFLLFFYFFSSHFSPLLQVNIHFLSVVHLFLLSSIFFILFLIPLSQPLSFLFSLFFYRIHFLTHTFSPFIKYIISFSPDSSLSLSLSFSPSPSMFLASLLHTILSFLSVRSPIIHFFFYLTLSFFRYDLPRHPHFASPSFSLFSSRASFPFLSITPPPTPFHFPLFSLSYPSFPFLICVLPRPSLNTHALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DRY2</accession>
    <name>A0A812DRY2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_58004</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003940">
        <property type="protein sequence ID" value="CAE1305617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DRY2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1305617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="275" mass="33024" checksum="DAE1603CC80B36EC" modified="2021-09-29" version="1">MIYLSIIRSFLTSFLLSFGTAHPLLSISYMCFLKIFVPKDILGNLFQLLFILSKFLQLLFKVIHSFRIFFSFSIFLTFSFFFSFHPVIFLLSFFLVFFFFHFIYFFSPSLNFTLFSLLFLNFLSTFLFSSFLSFISVFYLLFYMIFFCDSNFIFDFLSFFLSFFLSTFFSKFYCSLHCCLSFFFCPVVIHVNSFLCYLIFVINSSCFSFIFFIFSFFLFFVLFFFHSIYMPSIQNFITFIISLFIFSFPSFLYSFLPSFLLFLSFPSFLPSFHIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DS05</accession>
    <name>A0A812DS05_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_59665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004126">
        <property type="protein sequence ID" value="CAE1307608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DS05"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1307608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="224" mass="25915" checksum="499C940DEC78F2C7" modified="2021-09-29" version="1">MVDLNFGKFAPPLSLSLSPSLPLSPSLSLSQTFANYQIQKLTSLSFSCFLVYLFYYRRANMQSYLSIYLSIYLSIYLIMFISIYLSIYLSIIAKHTYSISLHIYLYIYLSLFIIYLSIYLSITVSLFSLSVCLSLMTDSYYLSIYLSIYLSIYHCLYILYLYVCLSLSHHRGLSTTRVRTVVLCVTSLFSLSLFFFLSLTHTFEVYQVQKSEDVLLSLSLISFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DS40</accession>
    <name>A0A812DS40_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SPHA_58856</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004055">
        <property type="protein sequence ID" value="CAE1306662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DS40"/>
    <dbReference type="OrthoDB" id="9049620at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="13"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="6">
        <location>
            <begin position="77"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAE1306662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="230" mass="26515" checksum="1257CE3E3EECEE1D" modified="2021-09-29" version="1">MASNVTEEETFQCSKCVESLDLASKTLPCLHSFCKRCVEEILGGNGRCPQCQEPATDKELRLAPFLVKSLRRRQLESRQLNCDTCSEDGMESSYQFWCQDCQKLLCQTCERFHKKFHPKHETKDLSGVSREEVIRVITMEDCRRHRQSKDVFCDRCNVFMCVACYTDHVTASPQCPSRPLSVREVASKGKEEGGPTLERELRQFEIHIRATNERTRRSIEELSTDCDSEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DSL8</accession>
    <name>A0A812DSL8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_59660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004126">
        <property type="protein sequence ID" value="CAE1307602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DSL8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="339"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="374"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="404"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="459"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1307602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="500" mass="60502" checksum="C89DD1A58706FF14" modified="2021-09-29" version="1">MSGGLVVEVPIKKDTRCKISLKIHSFFLSFFLSFCFFFLSFFLFIVSFFLSIVSFFLFFFLSFFFHSVVSFFLSFPFLSFFLSFLSFFLSFFLSFFLSPFLFIVSFFLSFFLSFFLSSFFSFFPFSFFLSFLSFFFFFLSFFFSFFPFSFILSFLSFCRFLFFLSFFLSFFLSFLSFFFSFFPFSFILSFLSFCRFLFFLSFFLSFFLSFFSFFLSFFLSSFFFLSFFLSFLFLSFCRFFLFSFFLSFFFLSFLSFFLSFFLSFLSFFFSFFPFSFILSFPFLFSFFLSFFLSFFLSFPQSLSHAQTHRHAYECLTSDFFLSRPLPITFIYSDSFLFRFLPLFFIYFDCILFLHLLITFIFSDCFLLRFLPLKYIYSDFFAFRFLSLTFIYSDSFRYRLLPLKFIYSDFFLLCSNILTSSIPNSSSYVHIFRPLPLRPLPITSYIPNRNASLKFISNQFFLSFFLSKSGSIYLSIYLSIFMPSISENIQMQIVHYKRTKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DV67</accession>
    <name>A0A812DV67_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_62031</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004400">
        <property type="protein sequence ID" value="CAE1310471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DV67"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1310471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="199" mass="23790" checksum="3F55C0EDCCA742E0" modified="2021-09-29" version="1">MSFHKSIYLFFVCQYRFIRLFLSIYLSIYLSIYLSQSVLKCVSIRENTLHHILDREEKYIYLSIYLSVCLSIYLSIYLSHSVQYLSHSVPHLSIYLSIYLSIYLSISFYSIFIYLSISSCSISIYLSIYLSIYLSIYKILFNIYLSIYQIPFNIYLSIYLSIYLSIKFCLISIKFVYLWCLSIYLSIYLSIYQSIYLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DW91</accession>
    <name>A0A812DW91_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SPHA_63550</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004553">
        <property type="protein sequence ID" value="CAE1312271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DW91"/>
    <dbReference type="OrthoDB" id="5914923at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045595">
        <property type="term" value="P:regulation of cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039680">
        <property type="entry name" value="PLEKHB1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14309">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14309:SF12">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="121"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="157"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="203"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAE1312271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="321" mass="34618" checksum="3798741DCEFAC7DA" modified="2021-09-29" version="1">MTDIIKAGWIQRHSKSFLEGGWKKVWVVLHRDSNLIFYKRQGDCDPKGSIFLKDVGKWFAVGQYTNGMPDRPDIPASSRLEHLLAIPVKPSSKAKIIWFLFSNDNELSDWMSAIVSVLPPAPRKSGGPPAQPSCPQMPYAGAPPPPGYAAGALNATAPPPYTQQVPPPPYAHHAAPYPQQAPYPQQPYPQQPYPQQPYPQQPGYPQQPYYPQQPYGQVPPPPPGYAAYPGQYPQQPYYGTQQPTVVHVEKKKSSGLGGIGEVALGVAGGALLAHGATSMMGGWGGGWGGGWGLGRWGSWSSLSSMSSFGSCGSFGSFGSWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DWC8</accession>
    <name>A0A812DWC8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">KCNT1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_61529</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004362">
        <property type="protein sequence ID" value="CAE1309889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DWC8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="284"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1309889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="362" mass="41570" checksum="19A260FDB42B7E9F" modified="2021-09-29" version="1">MLFSFTLHSSLYLYLFLPFSFFHPYIFFSIHFSPCFPLYLSLSLSLSLSLSLCLSSHFSQAFLFTFSISYPLFSINLSLSLSVSLSLSFSLSFYLSVNIAPLYCQIPWAYQSWSLFTLFLNLSIFLSIFSQPLSQLMSIGLISRSSSLLSFSTCISFSLFSLCLSLPLSVNFHVLIFLFLSDTHLVFLPLIFQRAYHLWPFSTLFLNFSKKKSLFFFVLSSLSLSFKKNISPNISRFSYILSFWPPLSNSLFMRAYHLWPFSTLFSILSISLSPFSRPLSSLSLSLSLSLSLFPSLFLNLLLSFLASILSHPLPQCPVTSRDFLYPFFVFTDFTFFCSHPFYFIFLFTNLLTLGISFLSLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DX63</accession>
    <name>A0A812DX63_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_61519</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004362">
        <property type="protein sequence ID" value="CAE1309888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DX63"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032835692" evidence="2">
        <location>
            <begin position="18"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="381"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1309888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="423" mass="51517" checksum="ABAF24FE0163B2D1" modified="2021-09-29" version="1">MYISFFLFVSLLHRSCHLPFFHLTHFLLSLPYRSSLIIVPPSPSPLNFCPIWAILLFRAWLNDVDIVFLSLSLSLFSLSLFRNLLLHIAIFFCANQTDGADVLSQLIIFSFSSGHTIETFMFSFSFFFLSFFLSFFLSFFLSFLFINPVMFYLSFFLSFFLSFFLSFLFCSLIQSCFPFRFFFLSFFLSFFLSFFSVHFFLFSFLFFFLSFFLFFFFSFLFINPVIFSFFLSFFFSFLSFLFINPSCFPFLSFFLSFFLSFFLSFLFINPVMFSFLSFFLSFFLSFFLSFLFSFLSFFPFLSFFFLFFSFLFINPVMFPFFLSFFLSFFLSFFSFIFFLSFFLSFLFINPVMFSFLFSFSFFSFFLSFFLSFLFFFPFRFFLFLSFFLSFFLSFFLSFFHISFFFFLFLPFFFYRSLFLMYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DY25</accession>
    <name>A0A812DY25_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_64295</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004626">
        <property type="protein sequence ID" value="CAE1313147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DY25"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1313147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="197" mass="21131" checksum="54E0A9B21708C4D3" modified="2021-09-29" version="1">MDNSLCQVNFLPSLSVLKLSSSLSLCLEAFFLNLSLSYLSFLSSLSVSGLLLRILSLSSPLSFRSLGYLLLPSSLYPLSGCQAISSSLSLMGFLPPSLSRYGTSSLSLLPCNFLPPPLSVSGHLPNLLGRLNLSSSLSLFFPFLSSSNLSVNLLSFFLPLSLSPIFLSNSNLSFPELSLQFSLLSLSSLPQSLCEAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E1J6</accession>
    <name>A0A812E1J6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_64703</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004663">
        <property type="protein sequence ID" value="CAE1313632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E1J6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="314"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="388"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="442"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="469"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="503"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="528"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="558"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="588"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1313632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="616" mass="72098" checksum="EFD9B26CCB2D369B" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E265</accession>
    <name>A0A812E265_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_66915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004832">
        <property type="protein sequence ID" value="CAE1316119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E265"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1316119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="276" mass="32604" checksum="ACD58FE3E43DE10E" modified="2021-09-29" version="1">MSVVPLGNYLYLSWFTSLSFPFFFSYLSKFSPIYLSIYLSIPVFSYLSISVFSYLSIYLSIYLSIYLSIPVFSYLSKFSPIYLSIPVFSYLSIYLSIYLFQFSPIYLSFSVFSYLSFSVFSYLSFSVFSYLSIYPSFLLSKFSPTYLSIYSIFSYLSIYLFQFSPIYLSIYLFQFSPIYLSIPVFSYLSKFSPIYLSIYLSIYFSFLLSIYLSIYLSFSVFSYLSIYLSFSIFLTYLSIFFSFLLSIYLSIYLSIYLRLEKKNWFSSPVINSCLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E3N8</accession>
    <name>A0A812E3N8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_65466</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004724">
        <property type="protein sequence ID" value="CAE1314537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E3N8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1314537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="243" mass="29774" checksum="37E29300453A0DA4" modified="2021-09-29" version="1">MFQSYSFLHLFSLIFSSFFFLDSFSLIPSFYPFFLSHFSWHFLIVFISLLFSNFIFIFCFYFHFYLHLILSFKIFLSFVINFLIYKLFSLLSFIQSFFYSNFFFITYIIFCNYFHFFFFGAFFCIIFFLCSVSFILKSFSVFEFHFFNSSLFFNIIILSFLIFTILSFFLSSSLTILLFFYFYISFIFLSLVLSFFLSFIFTVLPIFPSFFLFWLPFFPFFFLSFSFLSFLFCPIYLSFFLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E3Q4</accession>
    <name>A0A812E3Q4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_67613</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004896">
        <property type="protein sequence ID" value="CAE1316861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E3Q4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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            <end position="106"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1316861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="199" mass="22319" checksum="0C92981CD106E02C" modified="2021-09-29" version="1">MNLSIYLLLSHTHTQSFSTHTLSISLSLILSLTHTHSSLNHYHSLSLFHTHINTLSITLSLLTHSRNLSYSIYLSIYLSISHTHKHALSLSLSLSIYLSIYLSIYLSIHRSLPSVSHTLSHSLSHSLFIYLSIFHTQILSLSLSFSLSLTHTLTPAHTQSLSTTLSLSVSIYLSIYLSIYLSIYLSHTDILSLLISKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E4U7</accession>
    <name>A0A812E4U7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_65668</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004725">
        <property type="protein sequence ID" value="CAE1314691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E4U7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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            <begin position="226"/>
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            <begin position="258"/>
            <end position="281"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="302"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="332"/>
            <end position="354"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="422"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="453"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="487"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="510"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="538"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="564"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1314691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="594" mass="71840" checksum="8F561DEE687C2B61" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E5A3</accession>
    <name>A0A812E5A3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_65960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004744">
        <property type="protein sequence ID" value="CAE1314975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E5A3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1314975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="285" mass="32845" checksum="EEB0BBF0047DD066" modified="2021-09-29" version="1">MFIFSSPDPPPVSNIKPRCSGRTTQNALFPFKPGSVARSERAVNINYFDHLCLCPSLSFFFFFLSFFLSFFLSFFLSFFLSLCASLSFPRSLSLSHSMILSFSPYVSLSPFSAHLLSLISSFPRFDFSLSLSLSLSLSLCLILFLYLFLSRFLDLFHSFFFTFCFSSFLSFYVCPALYSPLSFTHSLYVSSYLSLTSTHSHPLSPSRYSFFLSFFLSFFLSFFLCVHLSSSLFLFSLSFVISLSFSLSIYLSIYLSIYLSIYLSIYLFFYIRPHTTRTTERKKFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E6G7</accession>
    <name>A0A812E6G7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_66634</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004810">
        <property type="protein sequence ID" value="CAE1315726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E6G7"/>
    <dbReference type="OrthoDB" id="6151198at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47018:SF4">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47018">
        <property type="entry name" value="CXC DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1315726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="295" mass="33436" checksum="E406F08D7D9A371F" modified="2021-09-29" version="1">MFSAMAIDQAHEQNNAVIKGDGGAVGLTEDPSALWRWMVAGSEISKFVADYEAISGSKEAKKGSHHHEQSPTAQKAFFEKVQWLTSVIEEMGNPFSEESTDLLSLDTKDIADPTAALLVASHLEKGKEQFQTFMDKLKTDSQHFYQPIKWNNKDFFKTSTDPTEKSETQLLKEDCQLFSRLFISCQSRGCDLSQFFKHENQSFPPSLNKRGKLHVATKFDLVDVLQTKVELPNTKPETDVLIVDGAFLVNTVTPKTFEEYARQDILPKVQYYSNNYKRTDINFDVYHESSLKSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E7I8</accession>
    <name>A0A812E7I8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_69818</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005106">
        <property type="protein sequence ID" value="CAE1319489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1319489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1428" mass="161788" checksum="F521286BC1C0652E" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EC97</accession>
    <name>A0A812EC97_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SPHA_68242</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004958">
        <property type="protein sequence ID" value="CAE1317720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="639027at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050502">
        <property type="entry name" value="Euk_RNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025">
        <property type="entry name" value="OS02G0815200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025:SF1">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1251"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1295"/>
            <end position="1314"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="202"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="660"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="763"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1079"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1176"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="683"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="764"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="775"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="793"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="811"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="825"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="838"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="872"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="956"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="987"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1089"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1180"/>
            <end position="1192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAE1317720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1317" mass="138672" checksum="C0D1A6011CBC748F" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ECM0</accession>
    <name>A0A812ECM0_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein naked cuticle homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SPHA_71039</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Farmed</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Cell autonomous antagonist of the canonical Wnt signaling pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the NKD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005201">
        <property type="protein sequence ID" value="CAE1320865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ECM0"/>
    <dbReference type="OrthoDB" id="5953812at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090090">
        <property type="term" value="P:negative regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040140">
        <property type="entry name" value="Nkd-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22611">
        <property type="entry name" value="PROTEIN NAKED CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22611:SF9">
        <property type="entry name" value="PROTEIN NAKED CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="21"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="194"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="287"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="354"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="194"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="222"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="292"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="354"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="380"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="404"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAE1320865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="575" mass="63425" checksum="05B5E0A5CE4F8D06" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EDB7</accession>
    <name>A0A812EDB7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_71038</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005201">
        <property type="protein sequence ID" value="CAE1320799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EDB7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="298"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="365"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="407"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1320799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="494" mass="57273" checksum="87C110B2C0789D2A" modified="2021-09-29" version="1">MQPDHSKIAPFSSLSNILFLSSSLPLSFSKRHPFFSLSYLTHSFFPFLFHSISLSFSLTFYISFSFWVLPFHLYPFFPDLSLALSLSHTYTRPIFFSFSLTLSLSLSLTHTHFISQKCYIFFFVSHYRTLSCILLKTIPFNLTHSPSLSLSLVRPLHFLENNIISFPYLIILPLSTYLSQILCFYLFTPLSFIFLSRKLSLLLIFWPLSLSSYFYTNSHCLLCLSHSLSLSPEYNISLFLSFFLSFHFPLLLFLSLFSLFSFSFTFLHLYLFVHLILLLLFPYTLFSPFSSSPDLMLFLPSFFSHLYCFLIFFPFSLSFLFSFSFSFMPNSFFLIPTFISFIPFSISLSLSLSLSHTHTFTLFPFAYLILSSFSISLVSFSSPFLFFLPLLSSILPHSSSLKLSLSYLYSFLSKYSSSFSLFHFFYHFPSQYLTFNSCLCHLFTFHPFPLPSISIHPVSLSSSLSQIHTRNLKGAKYVTSSFSFSSFLAFDRFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EE42</accession>
    <name>A0A812EE42_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_71373</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005222">
        <property type="protein sequence ID" value="CAE1321253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EE42"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032356404" evidence="2">
        <location>
            <begin position="17"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1321253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="162" mass="20433" checksum="3F827042756EEAA0" modified="2021-09-29" version="1">MFSFIVFFLLLLLCHLQPPDFDYFSHYYIHLDSLFTFLFIIFLHFLFFLSFCLLFYLSFYFFFLSYFLFLFCFHFFFLFVSFLSFCYLSFLPSFFLFYLLLNYFYILLFFIYFSLIDTPLPIFFLFGTFYNFIYFKFLKFFQAIFYYAIVSFSPVYNHFFHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EF88</accession>
    <name>A0A812EF88_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_73361</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005375">
        <property type="protein sequence ID" value="CAE1323466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EF88"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="155"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="186"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1323466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="272" mass="31517" checksum="865FC1E808892974" modified="2021-09-29" version="1">MPLFDLSNLILNFFHSDFFIIFLSIFLLSYRLLSFHFVFVVLFLFSSSSSSSSSSFSSSSSSSSSSSSSSSVFKEKFVRLLTLIYTYLSIYLSIYLSIYLSIYFLIPMSVYLELLSLTLSPPLSLSISFIWEIPLPVYLSFFLTIHLFHNTNVYLSIYLSIYLSIFNSYLSIYLSIYIHINFSISFFLSIYLSIYLSIYLSISVCLSLYLSIALSFYSYQSFCFYLSIYLFQSVCLYIYLSIYLHMNLSVSLSLSIYLSIYLSIYLSIYLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EHJ4</accession>
    <name>A0A812EHJ4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_73891</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005398">
        <property type="protein sequence ID" value="CAE1324049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EHJ4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="281"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="411"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="439"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1324049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="476" mass="53861" checksum="470FF5D1B8D303A0" modified="2021-09-29" version="1">MFFSLFYFYLSSSMLLCISVFTALLYVGFTLFYFLIHFSLSLSISFFLSFYLFLSFSLSLSLYVFLSLSLSLSFSLSLSLSFSFYLFLSLSFFLSLPLSFSISFSIFFLSLSLSLSLSFSLSISFFLSLSLYLFLSLSLSLSFSISFFLSLSLYLFLSLSFFLSLYLFLSISLYFSLYIPFFLSLSFFLYLFLSLSQSLSFSLSLYLFLSLSLSFLTLSLSFSLSFFLSLYLFLSLYLSLSLYLFLSLSLSLSFSISSFFSLSLSLYFFLSLSSSLSISFFLYLFISLSLSLSFSLSLSFSISFFLSLSLSISFFLSLSSSLSISFFLYLFFLSLSISFFFSLSLSFSLSLSFSLFLPLSLSLSSSLSLSLCFSLSLHFDFFQYLFSCFVPTSSSHLWLRAILSLSCSLSLSLSLSLSLSIYLSIYLSIYLSFTHTHTHILIPFLATVFLALSRVISLLALSSFSFFPGSDRTQSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EKF8</accession>
    <name>A0A812EKF8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ACTR3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SPHA_77264</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Farmed</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the actin family. ARP3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005511">
        <property type="protein sequence ID" value="CAE1327867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EKF8"/>
    <dbReference type="OrthoDB" id="421448at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10221">
        <property type="entry name" value="ASKHA_NBD_Arp3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000029">
        <property type="entry name" value="Actin-related protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000803">
        <property type="entry name" value="Actin-related protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000006">
        <property type="entry name" value="Actin-related protein 3 (ARP3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAE1327867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="390" mass="43902" checksum="AE8E36ED2C24C351" modified="2021-09-29" version="1">MAGRLPAVVIDNGTGYTKMGYAGNTEPQFIIPSCIAIKESAKVGDQAIRRLGKGVEDLDFYIGDEALDASSYSVKWPIRHGIVDDWDLMERFWEQTIFKYLRAEPEDHYFLLTEPPLNTPENREYTAEIMFESFNVPGLYIAVQAVLALAASWTSRQVGDRTLTGAVIDSGDGVTHVIPVAEGYVIGSCIKHIPIAGRDITYFIQQLLREREAGIPPEQSLETAKAIKERFSYVCPDIAKEFSKYDQDPGKWLKRYDGINSITKNAFSVDVGYERFLGPEIFFHPEFSNPDFTIPISEIVDNVIQNCPIDVRRGLYRNIVLSGGSTMFRDFGRRLQRDVKRIVDARLKASEELSGGRLKPKPIECQVITHHMQRYAVWFGGSMLASTVSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EMZ1</accession>
    <name>A0A812EMZ1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_73812</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005396">
        <property type="protein sequence ID" value="CAE1324000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EMZ1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="331"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="362"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="394"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="426"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="469"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="500"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="526"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="557"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1324000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="648" mass="76778" checksum="2CB28C2D75179740" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EN25</accession>
    <name>A0A812EN25_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_76224</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005486">
        <property type="protein sequence ID" value="CAE1326660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EN25"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1326660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="218" mass="24875" checksum="12C004901D4B2D78" modified="2021-09-29" version="1">MYVFPFPTSLPLPLSLSLSLSLSLSLSSFHLSVLLLFLAISFFHSSCYIIVIFYSSLLFCSLSFSLLSTSLCLFLIVSSVTTLSCSCRLAWGELIKKKSLLSPPFHFHFTHFFFLFSLFSFLLIFFPKLSLSLVFFLLSVFFHFLFLPTFFSSSLNLSFFHLFFLLSDILFLLILLLPSLLIILLSSHFHSPCLLFHLLSLLSLSLSLSLSLFILLHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ENB6</accession>
    <name>A0A812ENB6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_76824</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005498">
        <property type="protein sequence ID" value="CAE1327344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ENB6"/>
    <dbReference type="OrthoDB" id="6161790at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1327344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="301" mass="35822" checksum="04E02D59A990E161" modified="2021-09-29" version="1">MGAFTYVLKFIITQADADIIRNIREHLSICVYIYLSMFISVYLSIYVPVQNLKLEYLHLSIYVHVYLLIYLCTFLSLSIYLSICVNFYLSIYLCKFLSIYLSVFIYLSIYLSFFLIYLYLSIYLSLFVSIELSVHSFFLSFFSIYLSIYLYLSKSLCIYRTISPFSLCIYRTISPFIFSFFFFYLSIYLYISKSLCIYRTISPFVFSFFFFYLSIYLSLFVSIELSVHSFFSFFFFYLSKSLCIYRTISPFIFSFFFFYLSISIYLSLFVSIELSVHSFFLSIYLSIYLETNVVSLPGGFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ESA7</accession>
    <name>A0A812ESA7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_78957</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005555">
        <property type="protein sequence ID" value="CAE1329596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ESA7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032569438" evidence="2">
        <location>
            <begin position="27"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="284"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="346"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="376"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="404"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1329596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="464" mass="54302" checksum="3A55AC387A36D55F" modified="2021-09-29" version="1">MLVREYFTRVLCRCVLFCLPLHDILCTRWKSVNKSLSPRWLNERRSSFICFSRSNHSSCLSVSVSLSVCLSLCLCLSVCLCLSMCLCLSVCPSLSLSFFSSSFLTSLSIIYRSTSVYRSKYMFFSYVSRTICCSNPFLLITIQPTLSNIYLSIYLSIYLSIYLSIYLSVMYFIYLSIYLSIYLSISVFYSSISVFCLSINLSILTYVSILSINLSIYLSILSIYLSQYFIYLSISYFIYLSISVFYLFSVFYLSVCLSMYISILSIYLSIYLSIYLIFYLSIYLSIYLSVSPHFLLFMSIFLPRHLPSYQSKLVLIYLSIYLSIYLSIYLSIYLSQLLHLSIYLSIYLSIYLSIKVIIIYLAQIFIIYLSFFSYTYIYLCSYLSILFIFMCLSIYFSFFIYVCFFFISIYLSIYLSIYLSIYLSVLHCVVGHVRRLFSCVLWPHVELACCTWMCLARTSQPYET</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EU47</accession>
    <name>A0A812EU47_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_79459</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005568">
        <property type="protein sequence ID" value="CAE1330116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EU47"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1330116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="222" mass="25159" checksum="5D22C629FD54EEA8" modified="2021-09-29" version="1">MCLLDIAVSLFILSPLIPYLSRKTERWFLITRLTSQPYLHTQRTISLSCSYSASQRYLHSLAKHQVPVFSAVVHDPWTTVRGRSIREFLRSSAAQISSAYNLPFRTSAMSPVICCRNTNLLDSSSPYSQSIRMFAPPTLFGVHRHRPTCVYVLIATPIFSVGLRHLTLKAIMLAIYQTIPKHIGVFFFYPQRLLLANILVSCAHSLPLLEKSTVPNFSRESC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EX86</accession>
    <name>A0A812EX86_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_81068</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005621">
        <property type="protein sequence ID" value="CAE1331939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EX86"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="366"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="395"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="434"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="472"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
    </feature>
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        </location>
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        </location>
    </feature>
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            <begin position="973"/>
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        </location>
    </feature>
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        <location>
            <begin position="1001"/>
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        </location>
    </feature>
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        <location>
            <begin position="1032"/>
            <end position="1059"/>
        </location>
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        <location>
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            <end position="1120"/>
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        <location>
            <begin position="1149"/>
            <end position="1167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1331939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1221" mass="141694" checksum="22E85A246364E593" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EZ31</accession>
    <name>A0A812EZ31_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_79771</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005576">
        <property type="protein sequence ID" value="CAE1330466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EZ31"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1330466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="222" mass="26391" checksum="3FB63DEC1A5836F4" modified="2021-09-29" version="1">MPHLSYCLKMKKSDVSLLRLVNFNYCGVFTFLFLNLTQQWPLSFFSYNFLSFSHAAIFFHFPFLSIFLLSLSLKHASFYFSFSVMFFFWGGGFTSTHLFLFLSFNPPSHSLCCSLKHFFSLFIILTLPHFLLYKLSFSPLIHIPLLFLSFTLSLYPSVTPFLLLSFFIFFSFLIHPTFYLFLFLLFSLSRFLFLSFFFLHTHILIFIFRVILFTRAYHSKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EZE6</accession>
    <name>A0A812EZE6_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Splicing factor U2AF subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">U2 snRNP auxiliary factor large subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SPHA_81405</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Farmed</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Necessary for the splicing of pre-mRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the splicing factor SR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005632">
        <property type="protein sequence ID" value="CAE1332346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EZE6"/>
    <dbReference type="OrthoDB" id="10266058at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12230">
        <property type="entry name" value="RRM1_U2AF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12231">
        <property type="entry name" value="RRM2_U2AF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12232">
        <property type="entry name" value="RRM3_U2AF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000074">
        <property type="entry name" value="U2 snRNP auxiliary factor large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000097">
        <property type="entry name" value="U2 snRNP auxiliary factor large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006529">
        <property type="entry name" value="U2AF_lg"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01642">
        <property type="entry name" value="U2AF_lg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23139">
        <property type="entry name" value="RNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 7 8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="156"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="266"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="371"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="47"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAE1332346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="469" mass="52395" checksum="8ACDA401439D591C" modified="2021-09-29" version="1">MTDAEYLEFERQIAENRAADERRRGRSPAGPPGQAGPQQQGPVPGGRSRRSRSRSPRNRARSKERRRSRSRSPDRRKRRSRSRSPRDARISFSRRRRKPYKYWDVPPPGFEHITPMQYKAMQAAGQIPQTITVPNAALTLDTSVPFAGSAISRQARRLYVGNIPFGVTEEAMMDFFNHQMKVTGLAQAEGNPVIAVQINLDKNFAFLEFRSVDETTQAMAFDGINFQGQSLKIRRPRDYQPLPGMAETPSVAVPGVVSTVVQDSPHKIFIGGLPNYLNEDQVKELLTSFGPLKAFNLVKDSATGLSKGYAFCEYVDVTITDQACAGLNGMQLGDKKLIVQRASVGAKNAQNPVQLQIPGLNLNQGAGPPTEVLCLMNMVTPDELEDEEEYEDIVEDVKEECGKYGMVHSLEIPRPIKGVDVPGCGKIFVEFNSVIDCQKAQQALTGRKFSNRVVVTSYYDPDKYHRREF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ANJ4</accession>
    <name>A0A812ANJ4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_2793</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000080">
        <property type="protein sequence ID" value="CAE1149500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ANJ4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34723:SF7">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34723">
        <property type="entry name" value="PROTEIN CBG17025"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="273"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="302"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="337"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="397"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="420"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="457"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="484"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="536"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="588"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="617"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="645"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="679"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="703"/>
            <end position="722"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1149500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="723" mass="83537" checksum="488F673BD0F55D45" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AR54</accession>
    <name>A0A812AR54_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_4023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000123">
        <property type="protein sequence ID" value="CAE1153740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AR54"/>
    <dbReference type="OrthoDB" id="411630at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1153740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="290" mass="32347" checksum="1AA8FB3ADB03A0EF" modified="2021-09-29" version="1">MRNYLAVLLAKSSSFPAASLYSLLPSLSFHPKCFISHSSHLIFSLPVLVLLSTLFTQPSFSRYGTPIYPAVKDMAQVVYNTKGQWPNMTYMLSARVFSTSSTGLTSDPTLAPDISAFLPDVEDRISDTDQDPNTYPVTLYERALDEKQDEDREGTDNSYVHNGDLNAPRSSVDGSNNEDHSDMTLVRESSETEHQWKVVPHRLRGRNECTKSDMEQAELLNSDLKDKQLLDLPTTLYIGGLFESTDLQSRGRSEFHSAQMAIGHINEKGIIPGYKLDLVYNETAVSTVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ARL8</accession>
    <name>A0A812ARL8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_4297</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000134">
        <property type="protein sequence ID" value="CAE1154749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ARL8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1154749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="160" mass="19471" checksum="C90AE939605BD3BE" modified="2021-09-29" version="1">MLPLSFLLFFFCLWESLSLRFLFCPLFPSFFVSFFLYFCCCNYHDCHYIFFLLFAICFNFHPFFLFLFLSFGLFFGSFFLSPFEHIISVDFLLHAFFLFLLLFLSSLIHFNILYFFLLSFVLSFTDCIFLSISFYLRHLLLLSLRKFSFFLVICFSPRFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ASA1</accession>
    <name>A0A812ASA1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_5829</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000191">
        <property type="protein sequence ID" value="CAE1159083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ASA1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1159083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="268" mass="31926" checksum="75DC564A95D8210B" modified="2021-09-29" version="1">MYLTTDRAISKLCLYLYIFQSHSIHIYLSIYLSIYLSIFNLLIVYLFMATFSYLSIAIFSHLFLFQSVHIYLSIYLFIYLSQSVHIYLSIYLSIYLSIYLSQLFISISICSYLFISICSYLSIYLSIYLSIYLSIYIYIYIYISICSYLSQLVHIYLSISICSYLSLLLSISPFSNLYQPLEISFYHFYLFYYFLLSHIILTLSIYLSIYLSIYLSMSIFSYLSIYLSIYLSIYLSIYVHLFISIYLSIYLSIYLSIYLSIYLCIRCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ASF5</accession>
    <name>A0A812ASF5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_3570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000107">
        <property type="protein sequence ID" value="CAE1152759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ASF5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1152759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="220" mass="26115" checksum="073CD11E1CD507F8" modified="2021-09-29" version="1">MSRLFEFAFVFFQSALTVKETVSISLGICWRMPSPITRCSIRRRRHIRYFCFRMQMNRGSVCKKPHSTRLFIIYLSIYLSIYLSIYPSILVCSYLSIYLSIYLSIYLSIYIYIYISLSISIYLFQSVHYLSIYLSIYLSIYLSIYLSQSIHYLPIYLSLFYLSIYLSIYLSIYLSIYLSLFIIYPSILVCSYLSIYLSGLRRKIFECFRSISTSYPDISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AU72</accession>
    <name>A0A812AU72_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">GPS1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SPHA_4340</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000137">
        <property type="protein sequence ID" value="CAE1154959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AU72"/>
    <dbReference type="OrthoDB" id="422427at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048624">
        <property type="entry name" value="CSN1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019585">
        <property type="entry name" value="Rpn7/CSN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045135">
        <property type="entry name" value="Rpn7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145">
        <property type="entry name" value="26S PROTESOME SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145:SF2">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21151">
        <property type="entry name" value="CSN1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10602">
        <property type="entry name" value="RPN7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="8">
        <location>
            <begin position="205"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="414"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="417"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAE1154959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="434" mass="49792" checksum="5E50B990D0A73950" modified="2021-09-29" version="1">MPYPSICQALEEPMQVDVIAEEKDNGKKGFTVENATLDLESYSKHYEGFVKLNRLLFIINHCPTLKTETLQLALDCVQTTHDTNLYQQIYKQLQEMASSSSNSSVKVPPLDNHWIETTNRKAQQTLEKLDSDLKNYKTNSIKESIRRGNDDLGDHYLDMGDLCNALKCYSRARDYCTSPKHVVNMCLNVIKISIFIENWPQVINHIQKAENTILRSEMLSVNNVATYGTLCALALFDRQELQKNVISNLGFKMFLESEPQLRHILNTFNQSKYYFCLKLMEEIKNNLLLDIFLAPHIKKLYTLIRNKALCQYFSPYLSADMHKMAEAFNTNVKDLEDELMQLILEGQINARIDSHNKILYAKDIDQRSSTFEKSIAMGQEYERRTKAMILRSALIKYHLLVMCPVLKEKSPAASEVATPSGNSTPVQKLPVIPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AWF1</accession>
    <name>A0A812AWF1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">POMT</fullName>
            <ecNumber evidence="2">2.4.1.109</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_6540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="2"/>
    <dbReference type="EMBL" id="CAHIKZ030000214">
        <property type="protein sequence ID" value="CAE1160734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AWF1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1160734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="247" mass="28774" checksum="4120EB04420F7496" modified="2021-09-29" version="1">MRFLSYFFFSAFFLFSHSLSFFVPSYILLSLSLSLSLSLSLSLSVSNILSFFLSFFLSFFLCRFPTFFHSTSVFFLSLSSGLFRCFSFLHSFILSFILSFFLPLHYILFTSLSLTHCLFPSLSFFSLSLSFFALFLILSSLSISITFSLFPTFFSFSASFLHYLPFFHCFYIHSLFLSLPLFLHSYIPFSLSISHPLSLSLYLSLSLSLYIYIYIYIYIYIVLHSLPFSFSLSFSFIFFLSAFMQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B085</accession>
    <name>A0A812B085_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_8981</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
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        <location>
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        <location>
            <begin position="236"/>
            <end position="346"/>
        </location>
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        <location>
            <begin position="1113"/>
            <end position="1317"/>
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            <begin position="1837"/>
            <end position="1933"/>
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            <begin position="1857"/>
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            <end position="2193"/>
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            <begin position="2200"/>
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            <begin position="2200"/>
            <end position="2212"/>
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    </feature>
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        <location>
            <begin position="2214"/>
            <end position="2239"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF22964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAE1167759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="2465" mass="277719" checksum="9F2615DF4FAFFE88" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B307</accession>
    <name>A0A812B307_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">SPHA_10401</name>
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    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000335">
        <property type="protein sequence ID" value="CAE1169064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A812B307"/>
    <dbReference type="Proteomes" id="UP000597762">
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            <end position="37"/>
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        <location>
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            <end position="117"/>
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        <location>
            <begin position="123"/>
            <end position="146"/>
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        <location>
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            <begin position="249"/>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1169064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="354" mass="41663" checksum="7458CA64D9023AB4" modified="2021-09-29" version="1">MTMINYCLQISLSFCFVSFLLTPLFILSSATFAFIFFPSSTRLSVCVPSLFKMRTVLFLLAVSNIFVFFSSPFFDVSLHFFLVYFPSPFILNFLYLIISFFFFLYFFSFLTSFFSAILLYSLIYLFLLFYSVSLFSLFLVSFLLSFTSSSTPFFFSSIVFLLPIFLLIYLFFAFLYSRAFPSFLPSHFISPFFHLLFLFPFSRILLPPFFSCILFLLLSSFTSHIAFLRICFSFILIFSVYFPSYQGRFLFFLLFFVVLVRFCRILFICLPFILFSRLPSSLTLNYIYLLPSTRPLFILFPFCIVLDCIRFSLSISIPAPTSVLHHEISRFFLSSENQLRKKKRCIIIVPFFLV</sequence>
</entry>
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            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
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    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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            <begin position="314"/>
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        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1173118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="339" mass="41146" checksum="58652881C3AF1245" modified="2021-09-29" version="1">MRVSPISMPSVRYLSSLAHTSVPNHNKLFYNKNQIYLFFLSFFLSFFLSFFLSYLAFSFVLLFLLFNFFVRSFIFFLSFFLSFFLSFFLSFLSHFSTFLSVPFSFHFSFVFRLFLIFASFFLSFFFFLSFLSFSYLTFPHFSLFRSFFHSLFLIISFFLFFFLSFFLSFFLSFFLSFFLSPFIFLSFFAFFSFLRLSFFLSFCLSFFLSFLSDFSTFLSVPFVLSFTFSNYFFLSFFFLSFFLSFFLSSPFSHFCVFLSFFLSFFFSYQIFPHFSFVRSFIHFFLILSFFLSFFLSFFLSFLSDFSTFLSVPFVLSFTFSNYFFLSFFFLSFFLSFFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B892</accession>
    <name>A0A812B892_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_12033</name>
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    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
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            <taxon>Sepiida</taxon>
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            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000402">
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        <property type="component" value="Unassembled WGS sequence"/>
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        <location>
            <begin position="32"/>
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            <begin position="71"/>
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        <location>
            <begin position="105"/>
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            <begin position="139"/>
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        </location>
    </feature>
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            <begin position="173"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1172325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="238" mass="28433" checksum="39A80CF3DF7D8F23" modified="2021-09-29" version="1">MPVYLSQCFHIYLSIYLSIYLSIYLSQSFHIYLSIYLSLFMSVYLSIFGNIRVQTTASSSSSSSSSSSSLFYNRQPLIVNISSSSFFFFFFILQQTAACCCCFYFFFFFFFFFLLLLLLLLTLIFILQQTAASCCCFYFFFFFFFFFFFFFFFFFLFSCILQQTAVCCCCSFFFLFFSLFFHFFFFFFNVVIIIITFLIKSLYFSFSCFFFFKIGIITNKVLLKIRFFFFLSSSKSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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    <name>A0A812BCD2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
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        <name evidence="2" type="ORF">SPHA_13634</name>
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    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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            <taxon>Coleoidea</taxon>
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            <taxon>Sepiidae</taxon>
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            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <dbReference type="EMBL" id="CAHIKZ030000458">
        <property type="protein sequence ID" value="CAE1175360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BCD2"/>
    <dbReference type="Proteomes" id="UP000597762">
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    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="86"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1175360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="228" mass="26601" checksum="4E7EF60E4405EEA9" modified="2021-09-29" version="1">MLSIYSNLFIIYLSIYLSIYLSIYLSLYCFSIHIYLSIYLSIYLSICFNLFIVCLSIYLSIYLSIYLSIYLNLLSIYPNICSLSIYQSIYLSIYPNLFIIYLSINLSIYLSIYLSIYLSIYLSVLVCSCHSIYLVCSLSIYLSIYLSIYLSIYFIFLKAMRNAFQPTAIYLSQSVHNLSILICSLSIYLSIYLSIYLSIYLSLHYLSIYLSISFCSCHSIYLVMSYLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BER6</accession>
    <name>A0A812BER6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_15397</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000535">
        <property type="protein sequence ID" value="CAE1178699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BER6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1178699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="325" mass="38863" checksum="070F99426BED1261" modified="2021-09-29" version="1">MTLGLISLLVNSKRSLANTGIFFFFFFFLFFFFFFFFFFLAFNSSSFFNFLFLLLFLFPSFFRLLFCFLLAIVHLLFEATFFLSFSFFPSFSFFLCSPFTSSILNPFFLSFFLSFSCFELSFFFFIFYFEDSFFLSSSSSSSYSIVCCSISSSSSSSSSSSSFHFFFLLHCLLFHFFFFFFFFFFFFFLLHCLLLLFFHFFFFFFFFFFFLLLSFVLSFFSSSSSSSILNFFYFEAPLFVFFCFEATFFFIFIFFFYFKDSFFFLSSILTLLSYSALKLLSFFYSSYFDASFFLSFFLSPVSSSSFVYALLFFHVCSTSGLENIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BIN8</accession>
    <name>A0A812BIN8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_18216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000657">
        <property type="protein sequence ID" value="CAE1231736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BIN8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1231736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="254" mass="31084" checksum="843E69C440B7E985" modified="2021-09-29" version="1">MFHKIFLDFFPLKFFVFFFQYCTFHHFFPFLFLLFINVSFFFIFFLSLFFSFFLLFFSFFLFFFSFFFQFSFFILSSFLYLLKYIRSLFIHSPSLSFIHYFFHFRLFVFIFTLFSFQYSVPVCIFQPSFLFLSFYTFFSFFLSFYSFFFVPFFLRIQMPLSLISPLHSLLISFIGSFFFYTISVTDVLSNLLFFLPFFFVSHFHFVFLFIPTSYPNFCLLPSVLSTFLGSFLPIFLSSFLPSNLTSFITYFFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BJS1</accession>
    <name>A0A812BJS1_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vitellogenin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SPHA_18910</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000683">
        <property type="protein sequence ID" value="CAE1233326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BJS1"/>
    <dbReference type="OrthoDB" id="6484170at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045735">
        <property type="term" value="F:nutrient reservoir activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.20">
        <property type="entry name" value="Vitellinogen, superhelical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015819">
        <property type="entry name" value="Lipid_transp_b-sht_shell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011030">
        <property type="entry name" value="Lipovitellin_superhlx_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050733">
        <property type="entry name" value="Vitellogenin/Apolipophorin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001747">
        <property type="entry name" value="Vitellogenin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23345:SF15">
        <property type="entry name" value="VITELLOGENIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23345">
        <property type="entry name" value="VITELLOGENIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01347">
        <property type="entry name" value="Vitellogenin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56968">
        <property type="entry name" value="Lipovitellin-phosvitin complex, beta-sheet shell regions"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48431">
        <property type="entry name" value="Lipovitellin-phosvitin complex, superhelical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="234"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="258"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="282"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="305"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Vitellogenin" evidence="4">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAE1233326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="490" mass="56211" checksum="A75A33E76095AD22" modified="2021-09-29" version="1">MLAVSSLASGYCNLRPDCGKDSEVSHLIKKLIYLTHDCNIKNGDAKGIHFALRALGNIGHSQEQVSHLTRCFTNQDAPADIRIAAIDAFRRIPCDAKRSDLMGVFRDESEDSELRLNAYIALMKCPSRNVLSEKFGETDQFSATSYLRVFGNELRHWDTLKFRDFGQLIFDIIRKDRIEFRKSMSLLESGVIIPTCIGLPLNLTMTATGSVHLNRSRDIFRDRNIHHDSPSLHLSIYLSIYLSIYLSIYLSIYSVPDLSIYLSIYLSIYLSIYLFCSRSIYLSIYLSIYLSIYLSIYLFQSVPDLSIYLSIYLSIYLSIYLSIYRLYLSIYLSIYLSIYLSIYLSIYLSLPVSMSVCLNLSGRPFIYIYTFGRKFSDQLTFSSKLRDLSQMNSARYLGIVELSSKKKEFMNFKLNGHLAKAANHVETKFDLQYGSPKNKASNILKFSAVVNRSLKPFVHAYSYSMSIQHPGQVPFRILPFFPLISQSNYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BPT2</accession>
    <name>A0A812BPT2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NEURL2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_20588</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000756">
        <property type="protein sequence ID" value="CAE1237129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BPT2"/>
    <dbReference type="OrthoDB" id="10059069at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03717">
        <property type="entry name" value="SOCS_SOCS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.750.20">
        <property type="entry name" value="SOCS box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037962">
        <property type="entry name" value="Neuralized"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006573">
        <property type="entry name" value="NHR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001496">
        <property type="entry name" value="SOCS_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036036">
        <property type="entry name" value="SOCS_box-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12429">
        <property type="entry name" value="NEURALIZED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12429:SF8">
        <property type="entry name" value="NEURALIZED-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07177">
        <property type="entry name" value="Neuralized"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07525">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158235">
        <property type="entry name" value="SOCS box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50225">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SOCS box" evidence="1">
        <location>
            <begin position="141"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1237129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="208" mass="23304" checksum="F576DE8A67F3EBD8" modified="2021-09-29" version="1">MGKSWIYAVNKSHNRIFTGNIEIDEDQATEPYQPVVGNEDLIQTPRGTFSRSLLLPVRFPVERKNGHFIPKKGSILPTDVGSRIGIMYVVNEDRAEMHFIINGLDQGPCAKNIPYQDGPLYAIVDVYGTTKQVRIIQLYGVTSLQNACREIILQLVRKEDIDTLPLPTKLKQFLFGGNVQKKATAANTYLHFSSPLPLPSVYLFLSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BSI4</accession>
    <name>A0A812BSI4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_20971</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000768">
        <property type="protein sequence ID" value="CAE1237772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BSI4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1237772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="253" mass="29066" checksum="8D6C719776409BD3" modified="2021-09-29" version="1">MSSVGTSTDIPSIQVLNFYLSPLIYLSIYLFIYLVCQSEHIYLSLFISINLSHSEHIYLSISVCFYLSIYLSLFLSIYLSIYLSIYLSICLYLPPLIHLSLKEDIKSVWLPPSLSSVSPLLFSHLLSASQTSISLSPPPSVHIYLSIYLSIYLSIYLSIYHSLFISIYLSIYFRDISQSHHHHHHCLISIYLSIYLSIYLSIYLSIYLSLVVSIYLSIYLSIYLSISLFQSIYLSIYLSIYLSMRSLSKVSGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BSW2</accession>
    <name>A0A812BSW2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GAA1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_22956</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000847">
        <property type="protein sequence ID" value="CAE1241661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BSW2"/>
    <dbReference type="OrthoDB" id="445301at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007246">
        <property type="entry name" value="Gaa1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13304">
        <property type="entry name" value="GLYCOSYLPHOSPHATIDYLINOSITOL ANCHOR ATTACHMENT 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13304:SF0">
        <property type="entry name" value="GLYCOSYLPHOSPHATIDYLINOSITOL ANCHOR ATTACHMENT 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04114">
        <property type="entry name" value="Gaa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036762">
        <property type="entry name" value="GAA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="522"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="561"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="600"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="648"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="704"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="436"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="486"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1241661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="733" mass="83287" checksum="CEDC6F1BEB753C14" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BUR6</accession>
    <name>A0A812BUR6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_23061</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000854">
        <property type="protein sequence ID" value="CAE1241907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BUR6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1241907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="191" mass="21583" checksum="BE4361982203D31A" modified="2021-09-29" version="1">MYFLLEQPEGIGQVECSGQQKDALLGEPVRVAISINIHDVVGETFIVHIYLSIYLSIYLVALSVCLSVYLLNYSVSQSILSLHQYLYLSIYLSIYLSFYIVSSSISIYLSIYLSILSLCLSVCLSIYQTIVSLSLYCLFINIYLSIYLSIYLSVCLSVYLSNYSVLIYIVSSSISIYLDNLSIYLSIFSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BVB8</accession>
    <name>A0A812BVB8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_24760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000930">
        <property type="protein sequence ID" value="CAE1245525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BVB8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="353"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="387"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="439"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="503"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="538"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="572"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="608"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="640"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="672"/>
            <end position="688"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1245525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="689" mass="84416" checksum="ECFB33D1A7170668" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BWT9</accession>
    <name>A0A812BWT9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_28258</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001112">
        <property type="protein sequence ID" value="CAE1253205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BWT9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1253205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="296" mass="33640" checksum="B132073EF0DEFB14" modified="2021-09-29" version="1">MCLFRDAIIFCDVKIYLSIYLSIYLSIYLSHLYIIYLSVCLSVYHNLFVSIYPSIDRSISICTLSIYLSIYLSIYLSITVCSYLSIYHILFISIYLSIYRYNLQLRRVDFATVPIILSNPRIYLPHLSIYLSIDRTISICTLSIYLSIYLSIYVDSSMIETKKKLSVSTSLSLSLSLSFNLSLSNSYSFQLSLSISLSIYLSLFLSFHLSLFPPFPLSNSLSFYLSVFFLSQPTCLFPPLPLSTSPSFHLSLFTSVFLPLSFHLSLFPPIPLSTSLFSPLCLSTSLFPPLPLSTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BX36</accession>
    <name>A0A812BX36_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_23794</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000881">
        <property type="protein sequence ID" value="CAE1243393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BX36"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1243393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="379" mass="42426" checksum="26D9F5283041F9A2" modified="2021-09-29" version="1">MHSRSFSHANDEISGSVKCHTLYTHSRSFSHANDEISGSVQCHTPYTHSRSFSNANDEISGSVKCHTLYTHSRSFSHANDEISGSVKCHTLYTHSRSFSHANAEISGSVKCHTLYTHSRSFSRANDEISGSVKCHTLYTHSRSFSNANDEISGSVKCHTLYTHSRSFCHANDEISGSVKCHTLYTHSRSFSHANDEISGSVKCHTLYTHSRSFSHANAEISGSVKCHTLYTHSRSFSHANAEINGSVKCHTLYTHSRSFCHANDEISESVKCHTLYTHSRSFSRGNDEISVTVKCHTLYTHSRSFFHANDEISGSVKCHTLYTHSRSFSHANDEISGSVKCHTLYTHSRFFFHANDEISGSVKCHTLYTHSRSFSHAND</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BXG8</accession>
    <name>A0A812BXG8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_25358</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000959">
        <property type="protein sequence ID" value="CAE1246833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BXG8"/>
    <dbReference type="OrthoDB" id="10238283at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1246833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="348" mass="40583" checksum="8A6A740C011D11CF" modified="2021-09-29" version="1">MMSVWLNLTAVRLQSRRKDRAKRTILSSTIIMRVHMLSIYFFRSLSIYVSIYLTISAFITLSIYLSIYLSIYLSICEMLSIPLSLILTLSINIFFYEASSFFPPFLPSFIPFILTFSLNIFRYEFSSFFSLILTLSLPLSTSSFFPPFLSSFIPFILTFSLIIFRYEFSSFFSLILTLSLPLSTSSFFPPFLPSFIPFILTFSLIIFRYEFSSFFSLILTLSLPLSSIYPLSLILTLSITIFFYEASSFFPPFLPSFIPFILTFSLIIFRYEFSSFFSLILTLSLPLSTSSFFPPFLPSFIPFILTFSLIIFRYEFSSFFSLILTLFFPIKYLSPFSYSYSFYNHLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C1W8</accession>
    <name>A0A812C1W8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_28079</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001106">
        <property type="protein sequence ID" value="CAE1252732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C1W8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="189"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="254"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="301"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1252732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="388" mass="46828" checksum="B88D12BE6CB2F7C8" modified="2021-09-29" version="1">MTQGSIQPEQNTCPQGVRTGLSSTPKQSLHFFSSSTLQTNFSTSNPILVCFYSFPSFIFFFLFFLVCFYSFPSFIFFFLFRLFLFISFFHIFLSFLFSLFLFISFFHIFLSFSFVFIHFLLSYLFFFFVCFYSFPSFIFFFLFFLVCFYSFPIFHIFLSFSFVFIHFLLSYLFFFFVCFYSFPSFIFFLFFLVCFYSFPSFIFFFLFFSLCFYFRHSYFYFLIHFFPSLFSFIFFSFTCLSLNPSFSFFYLKIVLLPPIFLPFSFFFLFYFSCFSFFFLSFSFSSYSYLSFFRPPFSPPMLSFLLVPIFFFYSFIHFHSLIPSFHLLFLPSLINRSITRDLVKARNELAYRTSFFPSAAAAATTRFNRLSFAVMSRSAFCICLCVRHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C4W6</accession>
    <name>A0A812C4W6_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">DNA-directed RNA polymerase</fullName>
            <ecNumber evidence="2 9">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SPHA_27133</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Farmed</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the phage and mitochondrial RNA polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="2 9"/>
    <dbReference type="EMBL" id="CAHIKZ030001043">
        <property type="protein sequence ID" value="CAE1250481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C4W6"/>
    <dbReference type="OrthoDB" id="276422at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034245">
        <property type="term" value="C:mitochondrial DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001018">
        <property type="term" value="F:mitochondrial promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006390">
        <property type="term" value="P:mitochondrial transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000031">
        <property type="entry name" value="DNA-directed RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.280:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046950">
        <property type="entry name" value="DNA-dir_Rpol_C_phage-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002092">
        <property type="entry name" value="DNA-dir_Rpol_phage-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10102">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10102:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00940">
        <property type="entry name" value="RNA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00900">
        <property type="entry name" value="RNA_POL_PHAGE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00489">
        <property type="entry name" value="RNA_POL_PHAGE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5 9 11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase C-terminal" evidence="10">
        <location>
            <begin position="33"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAE1250481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="450" mass="51207" checksum="6EA7A269418C72E0" modified="2021-09-29" version="1">MDFRGRTYPCPPHFNHLGSDVTRSILLFAKGQKLGPRGLDWLKIHLINLTGFKKRSSNAERLMFANENMDNILNSADHPMEGRCWWQTSDEPWQTLACCMEIAKAVRSPDPAEYVSHFPVHQDGSCNGLQHYAALGRDQAGAESVNLSPSDQPQDVYSDVCELVECERAKDAKNGILIAQKLEGFVKRKIIKQTVMTTVYGVTRYGAKYQILKQLKDLQDFDPEYVWPACVYLADKTFLCLAEMFSATKEIQMWLTFCAHHIATLSLRPVEWITPLGLPVVQPYHKMSTFQRWGVSLSNSMSTFEKPNSLKQKNAFPPNFIHSLDSTHMLLTALYCLREGITYVSVHDCFWTHPASVEIMNKICREQFVALHNQPILEDLSKHLLKKFCTTSKGSSLQEVPNQRILQSMLGKVPKKGTFNLEQHLFSFFLLLCKLTTSCFSVNFANTKIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C5B9</accession>
    <name>A0A812C5B9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_30335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001218">
        <property type="protein sequence ID" value="CAE1256686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C5B9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="346"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1256686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="390" mass="46602" checksum="92A142A013D1EAFB" modified="2021-09-29" version="1">MALFINYFFLFLLNCLLVCFFLCFFFFLSFFLSFFLSFFLSFFRSFVLCFFPSSFPHHFYVITSPFVRSFVCFFVRSFDCLIVCLFVPFFVSLFICFFLMCFLIFLSVYIYSFFFFLFSFSFFLYFYFFSFFLCVYNFVCSNFHISPFFYFILSFIVSPYFFFFPFLSLSLVLFSFTCQLRQCICFYLTYIHSFFLFSFFLSFFLFDVLSISHSAVIPANSLYFCLRLLLSFFLFFFLSAVIFISLSSEIPANSFFLSFFLSFFLSFFLFVTITIICSYLLLLLLPHHLLPSFTHCFLVFLLLFLLFFSFSSFSSLLFSFVFFVFSFSSLLLIYPSFSFSLFFSSFSFLLLIFFSSSFFLLFFSFFLLLHWFSSLSSPLLSSSSSSSFPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C7C4</accession>
    <name>A0A812C7C4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_29801</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001193">
        <property type="protein sequence ID" value="CAE1255721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C7C4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1255721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="275" mass="33289" checksum="41007E5D9AD6AED1" modified="2021-09-29" version="1">MFIFHFFSSSSSSLPPPNYLLFSLISHSFSYLPSCCLFFSFFVIYFFLFHFFLLLFQCFHFIFQSLLMLFEIFISRSIFFYSFFSFFLFSFLLLLLLFLIRFSLFHSLFIPLFFFPLFFFLFSLPSSLLQLTFFISSFFSFPFLLHFSYSVNMLSFFFFFFLISFFLLLYSPLYLSRSFFFSVFISPSLPHLSFFFSLFFFFFTYIFHFLCFDLTFFLLPFTFSLITFIFALFFAYSDTSSKQKCYEKIVLRQLLKQGVSLKIILHFFINPSIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CA18</accession>
    <name>A0A812CA18_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_31104</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001265">
        <property type="protein sequence ID" value="CAE1258171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CA18"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1258171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="304" mass="35915" checksum="D143B3E8727CFE67" modified="2021-09-29" version="1">MVLSLSLSLSVFIWLSLSLVFCQHLILAIYQPLSVHIYLGLLIYLSIYLSIYLSIYISIYLCASVHIYLLQSDYIYLSIYLSRHVHSLSIYPCASVHIYLLQSDYIYLSIYLSIYLRLILFFVILHCVFVFFIFFFFFFFFPFKFFSPFLSSSFLPVFFFFSFFFVFIFFFFYILLLLLSSYSFLQLSSSSSPSSSSSSSSSSSSSSSHSLYLGFFLRLAFFSLSLLFFVLSFFLSLILLFPLSSSSFLLLLFFFFSIYLFSFFFSFLLLLYPSSSFFSFSFFEFLHLLLLFFFAFIFFFFLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CCV4</accession>
    <name>A0A812CCV4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_32474</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001355">
        <property type="protein sequence ID" value="CAE1260968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CCV4"/>
    <dbReference type="OrthoDB" id="5985440at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="64"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="116"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1260968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="297" mass="33642" checksum="332086CCA367FB56" modified="2021-09-29" version="1">MFDDFLLLLTSFQVPSVFYVPSSDWLVLLLLNKLAEETLAISISLTPKQIRDLAAQINATVKGLTDIEKILNETNDDLNRARRLKERADKASLEAGDVLDTADHVQKALEGAKMSQDKAAMAIDQVQEDIKNAKEDLQMIENIMSTSAANATKSLKIIKVLKDRLNSLEQKRYISQDKLSTAMKLTDQAMKTAIEAEKIAQDLEAKYNSTSGTLRNKYNATAASKERAILLKKRANELAVNTTKWNRELKRVVENFKKHSTEVDRLTLDIEGLQEKMKIYLDYIKRKAKYYAECLPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CEK1</accession>
    <name>A0A812CEK1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_32808</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001369">
        <property type="protein sequence ID" value="CAE1261524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CEK1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1261524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="235" mass="27797" checksum="FC3EC2529C8CDB5E" modified="2021-09-29" version="1">MCVCLFLSFSFYLSIYLSIYLSIYLSIYLSIYLSLRLSIYLSIYLSIYLSIYLSIYISPSLFIADYLSIYRNPSLFIVDYLSIYLSIYLSIEIHLCLFIFDYLCMYVSIYLSIYLSIYLSIYLQNNLCLCLCLCLSLSLSRGNLIVKISIYLSIYLSIYLSIYLFTAIIHSYLSIYLSIYQFIRIYLSIYLSIYLSSFVSIYLSIYLSIYQFIRIYLSIYLSIYLSICSLLHLFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CEX9</accession>
    <name>A0A812CEX9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_35698</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001546">
        <property type="protein sequence ID" value="CAE1267635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CEX9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134:SF22">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134">
        <property type="entry name" value="OS08G0543275 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1267635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="253" mass="28848" checksum="349C92C3FA93B4F7" modified="2021-09-29" version="1">MHIYLSIYLSIYLSQHVPILLNTLGNTLSLSLSLSLSLSLSQKLPATIYLSIYLSISTRSHVNMYVCLYVCMYVSIYLSIYLSIYENVYLSIYLSIYLSIYLSITTRSDVYMYVCLYVCMYVCMYVCMYVPIYISIYLSLKMFASIYLKMFASIYLSIYLSIYLSIYLSIYLKMFVLPRMSLYLTIDLFYPVIVAKSLPLRVSSSSSSSSSSSSSSSSSSYPSFCPSLFTATFSSLSSPFLCPHLLFALISFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CFR6</accession>
    <name>A0A812CFR6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_34972</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001500">
        <property type="protein sequence ID" value="CAE1266010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CFR6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="394"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1266010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="422" mass="49818" checksum="4A7BD6CC19E563E8" modified="2021-09-29" version="1">MHAFYLSIYLSIYLSIYLTYLSISAFPSFIPLTLILRSLFYFAFIPFRLLFRSLFYSIPSFIPQPLLFRSLFYSVPSFIPFRLLFHSVSNSVPSFIPFRLLFHSVFYSVPSFIPFRLLFHSVFYSVPSFIPFPLLFRSVFYSIPSFIPFPLLFHSVFYSVPSFIPFRLLFHSVFYSVPSFIPFPLLFRSVFYSIPSFILFSLLSRFLFYSAPFFITFPLLLCSLFYSIPSFILFPLLFYSIFYSAPAFIPFRLLFHSVFFTQPLLLRHLFYSIPSFTLLPLLLRSFFYSIPSFNPSSLLFCSLFYSILSFIPLPLLFHSVLNSIQSFIPFLLLFHSVFYSIPPQIPLRLLFRSLLLFHSVFYSVPSFIQFRLLFRCPFYSVSSIIPFPLLFHSFFYSAPTFIYRVENFCACLSLFIALESIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CHY8</accession>
    <name>A0A812CHY8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_37341</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001667">
        <property type="protein sequence ID" value="CAE1271709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CHY8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1271709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="317" mass="40182" checksum="00C8DEA01A1E7528" modified="2021-09-29" version="1">MNIFSFIFLFLSFFSLLPYLENVFIFPFFLSIISFILSFFLSFFPFFLSFILFFPFFLSFISFILSFSFLSFLHFFHSFFLYFLSFFHSFFFFSLFSSFLSFFLFSFLSFFPLFLSFFLFLFILFFISFILSFFSYIHFFHSFFFLSFFPFFLSFFLFSFFLSFISFIESFFISSFHLFLCFLFFFFSFSFNSFEFFFFFPLIFLFISFFFLFIGNFFLIYFISFSFFFFFFFHFFHFSSFFFFSFISFILFLYFFFLFNYIFIIFFFFYYFIFFFFLSFFLFLIFFLFFLYLSIFFLFFPSFSFFKFFFFFPLPIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CI21</accession>
    <name>A0A812CI21_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase A2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SPHA_36088</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001569">
        <property type="protein sequence ID" value="CAE1268456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CI21"/>
    <dbReference type="OrthoDB" id="6144264at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000130">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon opus-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAE1268456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="296" mass="33404" checksum="F4A83E0FA1D031A5" modified="2021-09-29" version="1">MHYPRCDPARQSTQGRTDYTSAVRVDPLSPQAPTRFLLKYRHPGIDWTSNTAVPSAYLQAVALKPDNAPSKLHDRTTTNDYFRLFYVWDRRNHIKFLVDIGAAISVIPPKEQQDRKATPYKLQAANGSTIETYGAKTLTLNIDMRRDFTWTFTQADVKTPILGADFLAHYDLAVHMNTTTLSDNTTNIAVKGTLSRHNTTGISLTTCHGREYIEILNRYPDLIQPLAGTGPAKHQTQHHIKTSGQPTFSHPRRLPPHKLEYTQKEFKNMLKDGFIRPSDSPYASPLHLVPKPGSTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CKN1</accession>
    <name>A0A812CKN1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_37708</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001690">
        <property type="protein sequence ID" value="CAE1272529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CKN1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="308"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="359"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="401"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="432"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="466"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="501"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="528"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="567"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="600"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="628"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1272529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="757" mass="87514" checksum="9825A61339F0E74C" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CNE6</accession>
    <name>A0A812CNE6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATXN2_2L</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SPHA_40648</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Farmed</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ataxin-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001925">
        <property type="protein sequence ID" value="CAE1277437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CNE6"/>
    <dbReference type="OrthoDB" id="2275718at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034063">
        <property type="term" value="P:stress granule assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00600">
        <property type="entry name" value="Sm_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045117">
        <property type="entry name" value="ATXN2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009604">
        <property type="entry name" value="LsmAD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009818">
        <property type="entry name" value="PAM2_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025852">
        <property type="entry name" value="SM_dom_ATX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12854">
        <property type="entry name" value="ATAXIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12854:SF7">
        <property type="entry name" value="ATAXIN-2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06741">
        <property type="entry name" value="LsmAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07145">
        <property type="entry name" value="PAM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14438">
        <property type="entry name" value="SM-ATX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01272">
        <property type="entry name" value="LsmAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sm" evidence="3">
        <location>
            <begin position="63"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="257"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="619"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="822"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="918"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="302"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="360"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="382"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="412"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="441"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="705"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="756"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="777"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="826"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="927"/>
            <end position="940"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAE1277437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="948" mass="104285" checksum="4FDCA0B94732D0C3" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CPV4</accession>
    <name>A0A812CPV4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_39994</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001879">
        <property type="protein sequence ID" value="CAE1276336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CPV4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="333"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1276336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="353" mass="41769" checksum="CBD59C61C7DA8E94" modified="2021-09-29" version="1">MPFLPSFLPSFLPSFLPSFIALFFFFGSFPPPFPFLHSNISFLPPNIPPFLPSLFLFLSYSFCICYFLFTSTPFFFLSFLPHFIFVSFSFIPPSSCFLFSHIFLPFVLHFLLFFLILQTFCFLFFPLLFIFFFSESYFIPASLSCINNYFFHSYIPGHYFSISLSPFFPSFRLRISFLSFYDLSHISFLMFSFSSPPALFLFYFFPEFFLLSIFVSFSIFYAHSILLPIVLSFFLSFFLSFVRSFFFRSFFLFLPPLNTPLSFFASVVFFYSFILYILKCCRIHMSIYLSIYLSIYLSIYLTACLSIYLSIYLFDCLFIFLCLVACRSACLRIYLSIYLSIYLSIYLSIYLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CPX8</accession>
    <name>A0A812CPX8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_41390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001984">
        <property type="protein sequence ID" value="CAE1278651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CPX8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="378"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="413"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="454"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="480"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="505"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="540"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="567"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="604"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="637"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="663"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="693"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="722"/>
            <end position="739"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1278651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="756" mass="88518" checksum="5357F82EA1B22DD3" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CQF5</accession>
    <name>A0A812CQF5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_38130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001724">
        <property type="protein sequence ID" value="CAE1273337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CQF5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1273337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="204" mass="23054" checksum="79334C9CD37B14E0" modified="2021-09-29" version="1">MPFNNKKSNVVRSLYHDDDISLKAFFFLKLRVDIHFAVKLFTFALLLLSLSHSLSLSHSLSLTIYLSISLYLFHSISLSLSLYLSHTISPSIYLSIYLTLSLSISLTLSISLSSYLTLSPSLSLSLSISIFLYFSIILSLYLSLSLSLSRSLYLSLYLAISLYLLRSLSLSIYLTLSLSLSPCRNARVYIYSYLSIYLSIYLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CRI8</accession>
    <name>A0A812CRI8_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">B9 domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SPHA_38767</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the B9D family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001778">
        <property type="protein sequence ID" value="CAE1274295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CRI8"/>
    <dbReference type="OrthoDB" id="431939at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036038">
        <property type="term" value="C:MKS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010796">
        <property type="entry name" value="C2_B9-type_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12968">
        <property type="entry name" value="B9 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12968:SF1">
        <property type="entry name" value="B9 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07162">
        <property type="entry name" value="B9-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51381">
        <property type="entry name" value="C2_B9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAE1274295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="198" mass="22460" checksum="1F183AB6DB3C4DEE" modified="2021-09-29" version="1">MASSSSVSVFLLNVSGQIESAEFLEFDDLYCRYSFVYGSDWAITSGLEESITQVTKKSQDSRQLLVWNFPLDVTFKSTNPYGWPRLMIHTYGSDAFGNDVVRGYGMCHVPLIPGRHKCRLPMFVPESTSQLQKFTSWLLGRHPEFVDAKIVAQGEGREVSRVRTQGFITVTFNISLHIYLSIYLSIYLSIYLSMALGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CU48</accession>
    <name>A0A812CU48_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_41700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002013">
        <property type="protein sequence ID" value="CAE1279329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CU48"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1279329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="253" mass="28849" checksum="003FC10FB7335D25" modified="2021-09-29" version="1">MPKYLDIVITLCSKCLPKYLDIVIPLCSECLPKYLDINLPLCSKCLPKYLDIVITFSSKCLPKYLHFAIHLCSKCLPKYLDIVIPLCSKCLPKYLDIVITFSSKCLPKYLHFAIHLCSKGLPKYLDIVITLCSKCLPKYLHFAIHLCSKCLPKYLDIVITLCSKCLPKYLDIVIPLCSKCLPKYLDIVITFSSKCLPKYLHFAIHLCSKCLPKHLDIVITSSSKCLPKYLDIVITFSSLPKYLELPIFAPNKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CX07</accession>
    <name>A0A812CX07_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_41771</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002015">
        <property type="protein sequence ID" value="CAE1279391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CX07"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1279391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="212" mass="25196" checksum="B962FCCEDEFE0DFC" modified="2021-09-29" version="1">MALGLHNVSFLSPCPEGVQFQLISSVSFSPPPFCLNKNYLSSSFSTKKINLSLYLILFRFFFTPSFLFFLLIFSTPPFFLLLVLHSPFFFSFYSSVFMFICTFFLCSLSPPSSLFLLFLCHPPFLLFFFILLPSLFSFSFLLLFFHSPFFFSFFILLYSSIFSFSFLLLFFHSPFFFSFSFFLFFSFSFEVFSFSFSFLLLFFPLFFFFFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CX49</accession>
    <name>A0A812CX49_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_43267</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002164">
        <property type="protein sequence ID" value="CAE1282160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CX49"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1282160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="171" mass="19516" checksum="9B0912421AA5B6B1" modified="2021-09-29" version="1">MIGPTLLITLPPPSLAERPEPAKCQLLSTARIGTSLIYLSIYLSIYLSIYLSIYLSSHVMYICIYFLSLTLSLSIYLVYCYVCMCLSIYLSIYLSIYLSIYLVMLCIYVSIFSLSLSLSIYLSCIYVSIFLSLSLSIYLSSHIVIYASIYLSIYLSIYLSIFSWLCYGLFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CXJ2</accession>
    <name>A0A812CXJ2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Leucine-rich repeat-containing protein 1,Protein lap1,Protein lap4,Leucine-rich repeat-containing protein 7,Erbin,Protein scribble homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SPHA_42010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002033">
        <property type="protein sequence ID" value="CAE1279867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CXJ2"/>
    <dbReference type="OrthoDB" id="2187496at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045197">
        <property type="term" value="P:establishment or maintenance of epithelial cell apical/basal polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098968">
        <property type="term" value="P:neurotransmitter receptor transport postsynaptic membrane to endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098887">
        <property type="term" value="P:neurotransmitter receptor transport, endosome to postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043113">
        <property type="term" value="P:receptor clustering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000118">
        <property type="entry name" value="Leucine rich repeat containing 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050614">
        <property type="entry name" value="Synaptic_Scaffolding_LAP-MAGUK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23119">
        <property type="entry name" value="DISCS LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23119:SF50">
        <property type="entry name" value="PDZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="4">
        <location>
            <begin position="127"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="493"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="500"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="526"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAE1279867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="557" mass="62705" checksum="F7D7C9D2C8220A0B" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D3Q1</accession>
    <name>A0A812D3Q1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_45517</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002346">
        <property type="protein sequence ID" value="CAE1285576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D3Q1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1285576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="273" mass="31323" checksum="B76BBCFC9AE15C0C" modified="2021-09-29" version="1">MYTIFLSIYLSIYLSIYLSIYFSFRSYICINPFLSLFLLCFLFLYSPTLAFNLYMLCLLFLYPHVLPSIYVCYAFFSCIPTSCFNLCMLCLLFRYPHILPSIYVCYAFFSSIPTICLQSLYVMPSFPLSPPFAFNLYPCSFPLSPTVCLPSMYVGSFFPLSCTFCLLIYVVYATFSSITPSCLCQSMCMLCLYSHSLPSIYPWASSIPPFAFNLVSLEFLSTFAPIMAGAISFILPESMYVMPFSIPRLRRIAFNLCRLCLTKLDPHLLIESM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D7D0</accession>
    <name>A0A812D7D0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_50770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003014">
        <property type="protein sequence ID" value="CAE1295147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D7D0"/>
    <dbReference type="OrthoDB" id="6819399at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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            <begin position="72"/>
            <end position="94"/>
        </location>
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            <end position="137"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1295147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="303" mass="34804" checksum="EDEC0B50FB6D766E" modified="2021-09-29" version="1">MTPFFDCFDDQVRFFLYCVVVSFKGVLDQNATGLPHSSQLSTCSLHQFQFQGFSSSRVRANSIYLSYTVQIYLSYTVQIYLSILFSSDLSIYLIQFRSIYLSYSVQIYLSYSDLSIYLIQFRSIYLSYSIQIYLSILFNSDLSILFNSDLSIYLIQFRSIYLYYTCPSSVYLSILLSLSIVFPSCLFLFFCLFLLYFLPTLFLPLQPLSKTLFLPLQPLSKTLFLPLQPLSKTLFLPLQPLSKTLFLPLQPLSKTLPLQPLSKTLPLQPLSKTLPLQPLSKTLPLQPLSKTLPLQPLSKTLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D8C5</accession>
    <name>A0A812D8C5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_51648</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003142">
        <property type="protein sequence ID" value="CAE1296809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D8C5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="301"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="359"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="391"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="519"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="575"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="600"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1296809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="662" mass="77608" checksum="E0116E877E80DD25" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D9I9</accession>
    <name>A0A812D9I9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_49403</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002822">
        <property type="protein sequence ID" value="CAE1292665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D9I9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="356"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="431"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="465"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="509"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="544"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="584"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="624"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="669"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="695"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="720"/>
            <end position="745"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1292665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="799" mass="93856" checksum="1068B9BA63CBEA01" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DCU4</accession>
    <name>A0A812DCU4_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">sphingomyelin phosphodiesterase</fullName>
            <ecNumber evidence="5">3.1.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">SPHA_50625</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Farmed</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the neutral sphingomyelinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.12" evidence="5"/>
    <dbReference type="EMBL" id="CAHIKZ030002998">
        <property type="protein sequence ID" value="CAE1294825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DCU4"/>
    <dbReference type="OrthoDB" id="387657at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004767">
        <property type="term" value="F:sphingomyelin phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038772">
        <property type="entry name" value="Sph/SMPD2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320:SF24">
        <property type="entry name" value="PHOSPHODIESTERASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320">
        <property type="entry name" value="SPHINGOMYELINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="789"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="820"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="16">
        <location>
            <begin position="477"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="186"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="393"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="197"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="218"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="396"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="406"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAE1294825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="865" mass="95427" checksum="5A3A84736F4B293B" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DI39</accession>
    <name>A0A812DI39_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_52678</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003313">
        <property type="protein sequence ID" value="CAE1298640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DI39"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032659697" evidence="2">
        <location>
            <begin position="38"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1298640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="252" mass="29648" checksum="70033A1D1379E5DB" modified="2021-09-29" version="1">MILWLSSSSSSSSSLFFFFSLLLLSLLLLLLLLSSSSQKCLSTSLSSSSLFIFILLLLSSSFFFLNYSFFFFFSFFSLPLLKISSLLVFLSPSPYFSLLLFLLSLLLSTSLFFFFSSLFFFSLFFSLFFSFLLSTSLFSPLFLFFSLLLPTSLFFFFFSLFFSSSSLFLLFFFFFSSSPSFFFFFFFFFPFLSSSFSLLFFFSFLPKSLSSFFSLLLFKFLFFFFFSSFLLFSLFSKSLQSWLSFFFFFFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DIS3</accession>
    <name>A0A812DIS3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_54389</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003536">
        <property type="protein sequence ID" value="CAE1301425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DIS3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="314"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="382"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="425"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="479"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="509"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="535"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="574"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="609"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1301425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="635" mass="74687" checksum="7355F8412F1EFA85" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DJB9</accession>
    <name>A0A812DJB9_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferroxidase</fullName>
            <ecNumber evidence="3">1.16.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SPHA_57050</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Farmed</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>4 Fe(2+) + O2 + 4 H(+) = 4 Fe(3+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11148"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.16.3.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the frataxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.16.3.1" evidence="3"/>
    <dbReference type="EMBL" id="CAHIKZ030003824">
        <property type="protein sequence ID" value="CAE1304488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DJB9"/>
    <dbReference type="OrthoDB" id="1897642at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034986">
        <property type="term" value="F:iron chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00503">
        <property type="entry name" value="Frataxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.10">
        <property type="entry name" value="Frataxin/CyaY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017789">
        <property type="entry name" value="Frataxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002908">
        <property type="entry name" value="Frataxin/CyaY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036524">
        <property type="entry name" value="Frataxin/CyaY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020895">
        <property type="entry name" value="Frataxin_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03421">
        <property type="entry name" value="FeS_CyaY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03422">
        <property type="entry name" value="mito_frataxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16821">
        <property type="entry name" value="FRATAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16821:SF2">
        <property type="entry name" value="FRATAXIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01491">
        <property type="entry name" value="Frataxin_Cyay"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00904">
        <property type="entry name" value="FRATAXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01219">
        <property type="entry name" value="Frataxin_Cyay"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55387">
        <property type="entry name" value="Frataxin/Nqo15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01344">
        <property type="entry name" value="FRATAXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50810">
        <property type="entry name" value="FRATAXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0409">Iron storage</keyword>
    <keyword evidence="6" id="KW-0410">Iron transport</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032433649" description="ferroxidase" evidence="13">
        <location>
            <begin position="19"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAE1304488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="184" mass="21120" checksum="860150092E7122FA" modified="2021-09-29" version="1">MVRSSMFFVVPLLTKSLACRNANIKCCKVLRKTRIQMNGTNIFSNQQRENTIIRKQYLSVDSSSSPGHLSQNMYETISHETLESLTEFCESLEDLEKCPKEFDATYSNGVLTLSFGAHGTYVINKQSPNRQIWLSSPFSGPKRYDFENGRWVYKHDGISLHSLLQKELSNIFDEEISMEHCAYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DK23</accession>
    <name>A0A812DK23_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">IPI1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SPHA_54369</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the IPI1/TEX10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003536">
        <property type="protein sequence ID" value="CAE1301384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DK23"/>
    <dbReference type="OrthoDB" id="361362at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071339">
        <property type="term" value="C:MLL1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024679">
        <property type="entry name" value="Ipi1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057949">
        <property type="entry name" value="TPR_TEX10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16056">
        <property type="entry name" value="REGULATOR OF MICROTUBULE DYNAMICS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16056:SF2">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12333">
        <property type="entry name" value="Ipi1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25781">
        <property type="entry name" value="TPR_TEX10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pre-rRNA-processing protein Ipi1 N-terminal" evidence="5">
        <location>
            <begin position="173"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="TEX10-like TPR repeats" evidence="6">
        <location>
            <begin position="594"/>
            <end position="890"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAE1301384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="895" mass="102176" checksum="C5AE8C4EFCCD4654" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DKA4</accession>
    <name>A0A812DKA4_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Germinal-centre associated nuclear protein MCM3AP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_56565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003744">
        <property type="protein sequence ID" value="CAE1303773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DKA4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031907">
        <property type="entry name" value="MCM3AP_GANP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16769">
        <property type="entry name" value="MCM3AP_GANP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Germinal-centre associated nuclear protein MCM3AP" evidence="1">
        <location>
            <begin position="13"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1303773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="336" mass="38280" checksum="A0F093B2989338EE" modified="2021-09-29" version="1">MLKLPEFVPANELSEKWSKAIEDVWNYIKIIIGDGPEKQAVELVSKVRNLLVRIEMQFSEACLLEFGQEGCLPTAVNVAWLDIIMYCINHLLITTPCLDTSSLEDQECPPEIEVVYRKSALTSYKPDVAWRDAASEMRMREGPTLKSTYIQSVSQMMQNKKSQSTELLKTQIESIKFSLDQDLMAINAKSIDQLKTSLNVEKLHNNNFEDFLERSLQEGFFEEENTFKNFGESGGSTLLDNCAEQSDKSDHWLCDGLTPVNKSTEYEDELSPDFESDHSLEDRITMLKNELESCRKASSFMECCLNSLVVDPFLVEMDTKHGDQDNSLSDRKPIPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DNE3</accession>
    <name>A0A812DNE3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_59812</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004146">
        <property type="protein sequence ID" value="CAE1307778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DNE3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134:SF22">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134">
        <property type="entry name" value="OS08G0543275 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="281"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="357"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="407"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="453"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="481"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="505"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="540"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="571"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="603"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="676"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="715"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="751"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="777"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="808"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="833"/>
            <end position="851"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1307778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="908" mass="103698" checksum="D216EB177CAC63EB" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DPH8</accession>
    <name>A0A812DPH8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_55498</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003702">
        <property type="protein sequence ID" value="CAE1303291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DPH8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1303291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="151" mass="17035" checksum="7A139AFD229A537D" modified="2021-09-29" version="1">MHTPIIYLSIYLSIYIRPLKKQTGAGKKPCSSICLIFVIPTILTYCDTTLLNKLDIMEVSVDNENTFTHLTTHSYVYLSASLKLYSSFSPFHKLSLILTHISVRLSIYLSIYLSISICVAAFRQGTICTYTPSLIPCLSVYFNLFITLSLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DRQ8</accession>
    <name>A0A812DRQ8_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase A2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_61160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004305">
        <property type="protein sequence ID" value="CAE1309472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DRQ8"/>
    <dbReference type="OrthoDB" id="10064107at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000130">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon opus-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001995">
        <property type="entry name" value="Peptidase_A2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053134">
        <property type="entry name" value="RNA-dir_DNA_polymerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559:SF444">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559">
        <property type="entry name" value="TRANSPOSON TY3-I GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50175">
        <property type="entry name" value="ASP_PROT_RETROV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A2" evidence="2">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1309472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="340" mass="38748" checksum="55B890F31A45345B" modified="2021-09-29" version="1">MSFLIDTGAQLSVVPPSPNFTKTNSSVTLRAANGTNIKTFGEQSLTLDIGLRRTYQWIFTVADVKFPILGTDILAHYQLIVDLSQRQLSDSTTKLSNRRIVSQLTSTELRIAVLRDNPIQDILDKFPSLIQPFTYTEPVKHSIVHRFRTTEQPVYSKPRRLAPDKYKIARAEFQNMLDLGIIRPSSSPYASPLHMVTKAQQGAWRLCGDYKRLNSQTVPDKYPVPNLTYFAVTLQGATVFTKLGLRKAFHQIPEPSSSFITYFRKKMSSLSFTPTRYTSRDVYVPPSLLECEYVFVRQDSVRKPLTPHYAGPFHVLARTDKYYTLHYRLTTADRLSLSIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DRU3</accession>
    <name>A0A812DRU3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_59109</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004089">
        <property type="protein sequence ID" value="CAE1307008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A812DRU3"/>
    <dbReference type="OrthoDB" id="6097716at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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            <end position="56"/>
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            <end position="635"/>
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            <end position="665"/>
        </location>
    </feature>
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        <location>
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            <end position="704"/>
        </location>
    </feature>
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            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="460"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="329"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="476"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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            <begin position="507"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAE1307008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="707" mass="79249" checksum="D314F5A20F06A748" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DRW8</accession>
    <name>A0A812DRW8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_59583</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004123">
        <property type="protein sequence ID" value="CAE1307534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DRW8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
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        <location>
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            <end position="84"/>
        </location>
    </feature>
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        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
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        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1307534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="240" mass="29373" checksum="B44BEE694372BF31" modified="2021-09-29" version="1">MCLSLRRPSPQAIPFLHDVARVISQYLSFTNFLLNNSFFFPFFSFLFSFLFFFSFLFFFSFLFSFFFLFFLSLFSLLFFLFFFFSLFSSFFSSLFSLLFFSLFFFFSFFSSLFFSSLFSLLFFSSLFSLLFFLFSFFSSLFSLLFFLFSFFSSLFFLLFFLFSFFSSLFSLLFFFSSLFFFLFSLFFFSFFFLFSLLFSSLFSSLFFSLFFSLFFFLFLFLFFFFFFSFLFSFSLFMAYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DT80</accession>
    <name>A0A812DT80_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cytochrome oxidase subunit I profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_58734</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
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            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
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            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004034">
        <property type="protein sequence ID" value="CAE1306459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023616">
        <property type="entry name" value="Cyt_c_oxase-like_su1_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50855">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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</entry>
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            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004513">
        <property type="protein sequence ID" value="CAE1311623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DVK7"/>
    <dbReference type="OrthoDB" id="10018757at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="284"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="316"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1311623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="431" mass="51000" checksum="E7C231D46899281A" modified="2021-09-29" version="1">MLTAEHKQRRVELPQQCLSRYEKDGDEFLKKVVTCDETWVWHLSPSSLTHSLSLSLSLSLSIYLSIYLSIYLSISLSICLSIYIYLLPSLYSLSLSIFYQLFSLSLYSTIPSLSLCSSLSLSLFLCIYLSLFPLYLSFLSISSSCFLSFSLSFSFIYLPFHLTTFFPFVSKFLTIYLSIYLSDPAIFIFLFLFSFPFLLNFSIRLSLFLYHPFHFSYFFSPLSLSCSFIYLFCLLFYYLLFFLLPTYNCFFFFFFFFFFFFFFFFFFFSISLSLYLPLCASSSLSFFISIHFPLSLCYLFTFFFFFHFFSFSFTLYFFPLFIFLASFFFIFPSLYLFFFSFLFLHFFSSFSPFLFLHFSLSVCLFIFLFLFSHFFPLSICLFSLSFSSFFSSFSLSPSLSHPLSLPLSLSKSTTIVLKIVKLHFLSIHLYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DVS7</accession>
    <name>A0A812DVS7_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_61760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004385">
        <property type="protein sequence ID" value="CAE1310104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DVS7"/>
    <dbReference type="OrthoDB" id="2016582at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1310104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="250" mass="27507" checksum="60CAFAF45A796041" modified="2021-09-29" version="1">MLIASNNIISSATGIQQDDPLGPLIFPMVVDGVGRSIASPFNIWYLDDATLEGPVEAVAADIRRVPLQSPKRLAQDFLNEIDITVKRCAELICNVNFDDTGWRQAKLPLSFGGLGLRSAVDLALPAYFSSFSSSHELIDEILGGSSQCFLGRSFEQACSAWTQELLSLPLDTPKQKSWDKIKCEANFTNLRLSLDQHDLACLLSASQPSSGAWLNAVPSSSTVYKRKKNCEYIYLSIYLSIYLSIYLSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DVY4</accession>
    <name>A0A812DVY4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_63188</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004531">
        <property type="protein sequence ID" value="CAE1311849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DVY4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="295"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1311849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="323" mass="37952" checksum="E7CE16A641C885F0" modified="2021-09-29" version="1">MTGSVFIRPCGPSRRRVTLLELRPPENSRRLLDKSLGQSYDLLPFSVLSHRQSTNPPSSLGLHSPAKSVDLTLREFLSRGTLGDFLSGHQDFLSFVAFSNDLQHVQLLHHKISLTQFIATSFYLFFFLPLLSFLSFFLFLFLLLLTIVLILSFSCRCIFHSFSFFFIFFLSFSFFLSSSSPSPFFFSFSFFFLNLLLSSSFLFLLSSSFFFLLLPLFSSSSSLFALYHFNFSSSSSSSFFFLSFFLFLFIPFLSFFIFLFLYLSNFLHFFFFLSFFNFVSFFLSFFLSLFLNNFFFFFIAFLSFLIFSFSFFLSFFLKFLFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DWL2</accession>
    <name>A0A812DWL2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_61931</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004391">
        <property type="protein sequence ID" value="CAE1310241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DWL2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1310241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="250" mass="30142" checksum="AA854EFD25929BBE" modified="2021-09-29" version="1">MHYMYFLASFFYLSFVRPFLSSLFLLLSFQRYFAIFLFHDFFFIPYYSLLVFYLVLFLYFQSFFFLPTSFFPIFRSFVYFFLQSCLSSFNVFLVCFFLSCFLFFIPHYSLFLFYFIYVSLLFPSLFLLSLSLFLSFFSFFSFFLSLILSTHINPHCFSYVCRDLLFLPSFLLLPYLSFYFVASFLVFLSFSMSFSLFLSFFLSFFLSFYIYTFSHFNPLIRDLIVFSLSLSLSLSLSRFLLFAAGTFFGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DY52</accession>
    <name>A0A812DY52_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_62029</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004400">
        <property type="protein sequence ID" value="CAE1310452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DY52"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="328"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="350"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="373"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="408"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="453"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="486"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="520"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="559"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1310452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="602" mass="71535" checksum="5C7A5289F9138A0C" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DYC6</accession>
    <name>A0A812DYC6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_64749</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004665">
        <property type="protein sequence ID" value="CAE1313667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DYC6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1313667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="152" mass="16755" checksum="6F28AFA68F731A57" modified="2021-09-29" version="1">MSTSITSFCLYYNPSNGSYHDEHPHSSECRGNDRPGSFAKRAKIPWRGNLSRRSKRASAAKRRQEEETEVEASQSISTEASLHRKATHNETSIRKSQETTAEKTARNTVKTAATSIRRSQEYMAEKTACHAAGTTAISAARASESYAQKAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E0Q6</accession>
    <name>A0A812E0Q6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_65991</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004749">
        <property type="protein sequence ID" value="CAE1315033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E0Q6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1315033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="229" mass="27270" checksum="C952983C91DF63C4" modified="2021-09-29" version="1">MYLSQSIHIYLSIYLSIYLSIYLSIYLSHLFISIYLSIYLSIYLSIYLSISVSSYLSQSLHICLHIYLSISVSSYLSNSVCSLSISIYLSQYVHIYLSIYLSIYLSIYLSIYLYIYIYISFLNIYIYIYHLLISIYLSIYLSIYLSIYLSIYLSQFAHIYLTQSVHYLSTYLSQYVYIYLSVSVCSYLSIYLSIYLSIYLSIYPSLFIHEYNDRLWHDIQNFHLSIVFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E1B2</accession>
    <name>A0A812E1B2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_62578</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004485">
        <property type="protein sequence ID" value="CAE1311098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E1B2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="319"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1311098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="419" mass="50485" checksum="0AB5F461855F347D" modified="2021-09-29" version="1">MLPIHPYSLSSSTLFSYYFPLIYHPAVFYSHFLSFMNLHIPFLSILARIFFFSFFLLFEFLPYPFLYPSFVFLNPVLLLSFVFHFISFIFLCYETFPFFSCFHASYRRARIFLLFFSSFMNILLFIHPAVKHVFLLFSFLLFYHMLPYPSSVFLNPVLLFPLPYPSSFFFPLILPLISLIVFVFFHILIFSIFRLPFRFIHPALKHVFSFFLSFFYEFFTISMLPYPSSVFCICSLIVLLPFTYSFFLYYETIFFFFSFSVFYIFFFFFSSLFISFISICHIHLLSSSTLSLIVLCPYHIYVFSLARIFFFFFFFMNAYLIHVAISIFCLSFVLLLSFVSSHILIFSIIYPFYRFYTSCRRARIFFFSFFFYECFTISFIAISIFFCLPQPCSLILSLSSFTYSHFLYLRRSLFFYILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E1I0</accession>
    <name>A0A812E1I0_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7041 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_64569</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004639">
        <property type="protein sequence ID" value="CAE1313408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E1I0"/>
    <dbReference type="OrthoDB" id="6260718at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055469">
        <property type="entry name" value="DUF7041"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327">
        <property type="entry name" value="ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327:SF3">
        <property type="entry name" value="RNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23055">
        <property type="entry name" value="DUF7041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7041" evidence="1">
        <location>
            <begin position="117"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1313408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="305" mass="33231" checksum="042C635FBE49A6C1" modified="2021-09-29" version="1">MSFDHHSSRLHSLHSSLLPSLCDASTPAASSSLLQLIPAPSSTTAASSSLLQLPALSCSLQLTLTASSTPTASSSLLQFTAHPWGPATLDSLTLGGRLVSSLLLELTVSAVNTVSLAYFKADPALFFTQLELECELRGITSQKTKFNLAVSKLPLEAVQEVREIIISPPKDKPYYKLKEELVWRTSMSRQKKLSQLLHEEQLGDSKSSQFLHHLQHLAGEGNEDGIIRHIFLQHLPSAYHAVLATVGKDASVEKLAKIVDNVADLTSGCTAPVSAIQTEEPDPLARLLEAQRRLEARMEDLERRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E2N8</accession>
    <name>A0A812E2N8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_64956</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004679">
        <property type="protein sequence ID" value="CAE1313897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E2N8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1313897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="230" mass="27145" checksum="12D62574C7B5DC01" modified="2021-09-29" version="1">MLSIYLSIYLSIYLSCISIIYLYISVFHIYLSIYLSIYLSIYLSIYLSISVCSYLSIYSSSFSIYLSIYLSIYLSIYLSAQFHSTNLGWYVSYNLSIYLSIYLSIYLSIYLSIYLSQSVLIFLSILVLFLSIYLSIYLSIYLSIYLSIYLSIKVFTLSLYILVSMIYLSIYLSIYLSIYLSIYLSIYVTFFISLYHGCYPNDESLVFSIKRNFCIEGRRKFLMKEKYIMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E4F9</accession>
    <name>A0A812E4F9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_64179</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004620">
        <property type="protein sequence ID" value="CAE1313032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E4F9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1313032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="212" mass="26010" checksum="1AF558CD69B02649" modified="2021-09-29" version="1">MPKTGFYVYEVTASFVSDSFNAFFLFIFIAFYISLLLYLLFLIFCSLLFHTFFFYSFLFLLSFLLLYFVFSPLLKLSLHFTFFTPDFLPLIYFSFAFNYFYVFFSFFRSFFISKLFIDFVIPYLFFHTNFFLLVFSRDSFLRFFPAFYVSHLLYFFFFSFSLFQSFFTPFFSSLLLYSAFPSFFVLFFTPFFIFVTFLLFLHFCFFRLSFCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E673</accession>
    <name>A0A812E673_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Caspase activity and apoptosis inhibitor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_67337</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004879">
        <property type="protein sequence ID" value="CAE1316676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E673"/>
    <dbReference type="OrthoDB" id="10064012at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038991">
        <property type="entry name" value="CAAP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14740">
        <property type="entry name" value="CASPASE ACTIVITY AND APOPTOSIS INHIBITOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14740:SF3">
        <property type="entry name" value="CASPASE ACTIVITY AND APOPTOSIS INHIBITOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15335">
        <property type="entry name" value="CAAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1316676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="231" mass="26627" checksum="AEC275037FFD2999" modified="2021-09-29" version="1">MMWNSLLRKCNYFNEKCLSHLWGKCRLFYINLAFKNFSLTVDAFFFSTLFLMVADSTQSDSALERKKRRRDDKDYHKKNKRDGNRSRHSHSPHRNSSSSRRSAGSHSEKSSQKEEDSDNSDMDLSKPLKPIGSYIKNRSEMLDQMFHCIKGSTLKSAIPEELKCMSYQELKQHCLAQLEVMSKKRILRILAGDDPANISSSGTEESGDDLENKRTDSTQILGREPESDHFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E7C4</accession>
    <name>A0A812E7C4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_69795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005106">
        <property type="protein sequence ID" value="CAE1319402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E7C4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="287"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="330"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="368"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="402"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="440"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1319402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="496" mass="57834" checksum="198BEA3A37439401" modified="2021-09-29" version="1">MVAKKLTLSLSLFLNQVLSIPFALSLSLSFLSLSLSLSLSLSPFMISMPLYFSPFFFLMNFHPSFFFPFCSLYAFHQTLSSSSSSPSLVVFHLLILPLNFFLLLYFHLHFTRLLLLTISSSSLFSSTSLFLQLSPHLCLPFLATSSPFSFFFVFFLSLPLLSFHQLLPSSIFSHRHVFYFNNFLSRFILFLFPFSSLSLLFLYRLLSHTFSFSLSLFSLNFLHSTSPCLLHSCSTPSVFSSSSFFSGSAFRLCLFFSLFIISFLHLSFPLSFIFFSFRIHFNLSPSLLSFYSHYFFLLPLSSITSLIPFFTPSGLRPYHQLSSLPLLSDFLISSFSAYVVFVSFPEFTCLYLSIYLSIYLSIYLSLSLYIYIYFFFLFSQTLLFSLLPFLRSFEMFYFFPSFYVLYPFVGLAIICLNLFYFLFFPIVHIFFILFCDIPRTYILFFLLISQYLLFFYLPPNLFLFRLFLYFKPAFSSVFHKTKGKRKSSTAPRFIAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E7E0</accession>
    <name>A0A812E7E0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_66998</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004836">
        <property type="protein sequence ID" value="CAE1316263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E7E0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1316263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="317" mass="37715" checksum="A601D972AD72FA93" modified="2021-09-29" version="1">MYSFSLCSFRMTLTLFSFIDLVVLIFIQQRCLPFYFSVNSFFLLLRRFFILSSTTFLHFYLFGITSSTLHYFFFGLSFFPSVPLTFFFFSAFPHSFFLGRFFSRFYSAFPYSFFFNISLISSVFLRSFYLFVFSCLLFHSPLFLMSIIIPIIYFSLLHTLSFYRLFISFFSLFFFFFYCSFFLIVAFVSSLIYSMTPFLFKCLQFFIFNELNFCASIFLSYSLSTLSRLSFFAAFSYLSHSLPHFPLSVDISNQKTYTPPPYVKLSLFLSLRHEMFVASIFFHFLPPCSCTDFYCPSLEIRHPINYLSIYLSIYLQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E888</accession>
    <name>A0A812E888_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SPHA_68504</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004986">
        <property type="protein sequence ID" value="CAE1318032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E888"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAE1318032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="210" mass="24861" checksum="6C2B5204C48274EF" modified="2021-09-29" version="1">MYYACFLCACLSIYLSIYLSIYVILFIIIYLSNLILFLIYLSIYLSIYYIYLSIYLSNLFHYLSIYLSIYLSIYLSNSVHYVSKLNTNNIIYPTLSYLSIYLSIYLSIYLSIYLSQSVHIYLSIYLSIYLSIYLLELFSLDYILSIYLSIYLSIYLSICLCVCLSIYSKFVIHNNMKNFNSPVYLLFVIYLSIYLSIYLSIYLSIVNQRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E9B0</accession>
    <name>A0A812E9B0_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ecdysone receptor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">20-hydroxy-ecdysone receptor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">EcRH</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Ecdysteroid receptor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Nuclear receptor subfamily 1 group H member 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">SPHA_70861</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005188">
        <property type="protein sequence ID" value="CAE1320634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E9B0"/>
    <dbReference type="OrthoDB" id="5837785at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035100">
        <property type="term" value="F:ecdysone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004879">
        <property type="term" value="F:nuclear receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035076">
        <property type="term" value="P:ecdysone receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000031">
        <property type="entry name" value="Ecdysone receptor A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003069">
        <property type="entry name" value="Ecdystd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050234">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24082:SF507">
        <property type="entry name" value="BILE ACID RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24082">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01283">
        <property type="entry name" value="ECDYSTEROIDR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8 14" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 14" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 14" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="16">
        <location>
            <begin position="63"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="17">
        <location>
            <begin position="202"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="148"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="157"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="168"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00033286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CAE1320634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="447" mass="50999" checksum="30FF83D4012915C2" modified="2021-09-29" version="1">MGKVVLKDGSSNNDTFNLEEPLSSLCMNIINDNKVTSSNQKSDKDLQGDSQKKQLSLRKPVEEELCKICGDRASGYHYNALSCEGCKGFFRRSITRNAVYTCKYGGHCEMDMWMRRKCPACRLVRCREVGMKQECLLSDDQCKARDARRKAKKKLSKKPDTNIEEKTFTSPNDSLPNSDKLSSKILPINVKNTDPLTKLSQQQQELIKNLVYYQEKFEYPDESYINTIKNVSSVTTDKSQEELQSSMLEQMALICVFMTKLIIEFAKQLPGFQELPKEDQIVLLKEASNEVTTLRAARCYDPKNRTIVFMTGIPVTQENMSALGIKNYAEVAFGFFHSLSQLCTDNTEYALLTAICIFSERPGLKNPALVEKYQENFVSALYNYEHQKRNNGGCAFAILISRLTELRTISLKHSQDLLDLEMDRTFIPELVKEFFSIESKEETTSLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EAL1</accession>
    <name>A0A812EAL1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_70121</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005126">
        <property type="protein sequence ID" value="CAE1319810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EAL1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1319810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="325" mass="37425" checksum="0F644B84E3E5F76F" modified="2021-09-29" version="1">MRWKVEDRKASMVGTDWQELFSFFIFLTLSYPRHFFFFMALLSKPILYFSIIFSPYHSSFSCPSYKSLPPPLSYQSLINLSIFSIPNPFLKLTPSLLSFLHLFPQPAIDGSNRPILLNEKPSADRLCIFSLFFNQFFRSKSINQSIVPADSPGFRSSLLHRASIYLSIYLSIYLSIYLSIYLSFQFFMPFPLSSSLSIPKNCSCFFLSEIIGERERERHREREREREGVLFLSLSLTLSLSLSLTHTLSLSISAHICVFRLMANHTDSSASLCTNLEFTIYLLLSLSLSLSPSLSLPLSLWCTFYLSIYLSIYLSIYLSVRICDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EAV4</accession>
    <name>A0A812EAV4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_69774</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005103">
        <property type="protein sequence ID" value="CAE1319359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EAV4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1319359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="224" mass="25623" checksum="49A9BA418523BE79" modified="2021-09-29" version="1">MASCNRGTIYLSIYLSIYLSIYLSIPDCSYLSIYLSIYLSIYLSKSAHIYIFSLFIIHLSVCLDLFISISRFSLPMYLSVCSYYLSIYLSIYLSVCLSVCLFISIYLSYIDLSMSIYLSTLSSSSCSYLSIYLSIYLSISLFISIYLSICLSVSSYLSIYLSICLSVCLSVCSYLSTYLISICPCLSIYLYCAVHIYLKFFSYLSIYQSVCLSIYLSIYLTYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EBI1</accession>
    <name>A0A812EBI1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_71876</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005270">
        <property type="protein sequence ID" value="CAE1321876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EBI1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1321876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="279" mass="31420" checksum="6B561014BC77808F" modified="2021-09-29" version="1">MPVETNSSAGLGSVLSLSISPNLAHSLSPALCHSLTLKYSLPLSFYDPHLLSLSLSLCSFSFTLFLAFSLTFTLSHTLTLNFLSLTRSLTFSLTFTPSHLLSLPPAHPLLTHSLLPFLPSYLSHPLSLPSSLSLSPTVTLSHPLSLTITLFFSFFQKVICSYLSIHLSEPVHIYLSIYLSIYLSIYLSIYLSESVHIYISIYLNLFISIYLSIYLSIYLSIYLSVSSVHIYLSIYLNLFISIYLSIYLYVSVHYLSIYLSIYLSIYLSIYLSMLTRISH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EEX5</accession>
    <name>A0A812EEX5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_72394</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005316">
        <property type="protein sequence ID" value="CAE1322393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EEX5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1322393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="239" mass="27637" checksum="0167E3DCC6CAEFE5" modified="2021-09-29" version="1">MNNIFLLFCFISLILSAPFSFTFFFLADFSSTSLKYSNFPYSLSLSLSLSHVRARFDSLSFSFYLPLSLSLTLYFSFFFSLSFFLRPLSLSLSLSIYLSIYLSLIHTHNLSLFHYYLLVSRIIISVSFSNYLYLSRSFSRFHSLSLTRFLSIYLSIYLSIYLSIYRLFSIYLSLHSSSLSLSLSLSLSQFYRMFFSACSDTRTVCPSLSFFISLSLSFFVLRCISISPTSLLRADINIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EEY4</accession>
    <name>A0A812EEY4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_71339</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005219">
        <property type="protein sequence ID" value="CAE1321190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EEY4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1321190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="270" mass="31056" checksum="E1AD40DFCB227C59" modified="2021-09-29" version="1">MYLSLLILFFILFLSLSFSLSLSLSLSLSLCVFLFIYLSIYLSIYLFMLIFFLYLYSLSPSLALSVSIYLSIYLSIYLSISFNFIFVFIFSLILCFSLSIYLSIYVNFLFISIISLCPFTIHSHIFFLLSLSLPFSDSYTYTLFFFLTFFSLSIYLSIYVNFLFVFLSSLPLSLSLTLTPTICFLHGSINSLYLFTIPSHILSLSLSLSLSLSLSLSLSYSHTYTLFFFLSVLTLSLSIYVNFLFVFISSLSLPYSHTYTLFFFLTVVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EHL6</accession>
    <name>A0A812EHL6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_72468</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005327">
        <property type="protein sequence ID" value="CAE1322527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EHL6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="345"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1322527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="375" mass="45652" checksum="F981FE94BA6FB031" modified="2021-09-29" version="1">MPFLPRGLSIFLSIFLYYDHYIYHSQFIPIYLSIYISLFIYYDHYIYHGQFIHIYLSIYISIYLSILVSSYIMIIISIIVNSFLSIYLSIYLSYQFIPIYLSIYISLFIYYDHYIYHGQFIHIYLSIYISIYLSILVSSYIMIIISIIVNSFLSIYLSIYLINSFLSIYLSIYLSIYLSLFIYYDHYIYHSQFIPIYLSIYLSIYLINSFLSIYLSIYLSIYLSILSIHSYLSIYLSILSIHSYLSIYLSLFIYYDHYIYHSQFIPIYLSIYLSIYLINSFLSIYLSIYLGLFIYYDHYIYHSQFIPIYLCIYLSIYLSYLFIPIYLSIYLSIYLSYYHILFIPIYLSIYLFLYYNFVAYFLCLLSIWISKYYNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EHR9</accession>
    <name>A0A812EHR9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_72800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005344">
        <property type="protein sequence ID" value="CAE1322856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EHR9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1322856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="259" mass="30646" checksum="B46CC6FACBA7AC7A" modified="2021-09-29" version="1">MTFRNPNSRIPHSFILQIFIPYSLSSFHYSLILNSSIPLLPIPLYYFLIPYFYSLFLNYYYSLIHLFSYYTFIYSIPLFLIIIPYSTIPSPHSLIFSFSYSLIFHSLIPYSHSLNLPIIILIPLFLYLFPFLNSYPPIPRPHSFIPHSLIPESLYSFIPHSRIPLFLFPHSSFQNPFIHSLINPLFLYSSFPHSRIPLFLYPSFQNPFIPLFLIPSFQNPFIPLFLIPSFQNPFIPLFLIPSFQNPFIPHSLIPEFFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EJ44</accession>
    <name>A0A812EJ44_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_76459</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005490">
        <property type="protein sequence ID" value="CAE1326931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EJ44"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1326931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="218" mass="25527" checksum="F648656190A6FD67" modified="2021-09-29" version="1">MHLLFILYFSLFFSFLSSPTVGFITRIYLSIYLSIYLSQSLHIYFIYLSTKQANILFFLQILLPRPLFFYSYTDPLYLPLNTVSRPIRPHFRFSLFYFRFIFLTIRHVFLHNSLHRFLFRSHCLYSPLFCFFIFFFPLLKPSSNACSLYSLTRKYYFLSLSLSHPHSLSLSLSLSLSLSPSLSHSPSFYLSLSLTQSLSLSHTLSPSLSLSLSLSTMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EJV2</accession>
    <name>A0A812EJV2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_74930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005443">
        <property type="protein sequence ID" value="CAE1325297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EJV2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1325297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="221" mass="25520" checksum="5D97637ED8037F8A" modified="2021-09-29" version="1">MYNLIQLKSIYLSVSLSIYLFASIRSCDSFPSSSLPSPLLILSFFFLFLLYLLSISRFLSNTKSYLSMTVKSVYLNEVISIYIYLSTYLCITVKNYLVTVKYLFIYLSVCLSIYLSNYLSVCLSIYLSVYLSIYLIIYLSIYLSVYLSICLSIYLSVCLSIYLSNYLSVCLSIYLSICLSIYLIIYLSVYLSIYLSICLSIYLIIYLSVYLSIYLSVYLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EJV7</accession>
    <name>A0A812EJV7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_76944</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005499">
        <property type="protein sequence ID" value="CAE1327456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EJV7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="279"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1327456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="331" mass="37569" checksum="C457D22D50A3CE46" modified="2021-09-29" version="1">MSIYLSIYLSIYLLKTFLFYLSGKLNTTLSLQQPAPYNCASLHPAPYDCASPHPAPYNCASPHPAPYYCVSPAARSIQLCLAAARSIQLCLTRSTLHTTVSRRTPLHTNVSHQEPAPYNCVSPQPAPYNCVSPQPAPYNCVSPAARFIQLCLAEACYFDLRMNKISIYLSIYLSIYLSIYLSIYIFSAHIYLSESVHIYLSESVHIYLSIYLSIYLSIYLSIYLSISVHIYLSLFISIYLNLCISIYLSIYLSIYLSIYLSIYLSVHIIYLCSESVHIYLSISVCSIYLSVHIYLLFISIYLNLCISIYLSIYLSIYLSIYLSVCLFISSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EL34</accession>
    <name>A0A812EL34_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_74411</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005429">
        <property type="protein sequence ID" value="CAE1324730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EL34"/>
    <dbReference type="OrthoDB" id="6159822at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327">
        <property type="entry name" value="ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327:SF3">
        <property type="entry name" value="RNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1324730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="159" mass="18233" checksum="A7E0BC4E6A20EC13" modified="2021-09-29" version="1">MKNLLGKNSMSDSLFRKLWMDKLPTHTTQILATLPEDLDLEKTAEIADKISDAATISSVNAPTLRDTPREDEFNKLQQQINRLSEQIDRLFRERLSSAHKLYKSQRRSRSNSRGRNDVYCWYHRKFGQAARNCTKPCNFKQQPTSTSCQEAGNAIPNSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ENG5</accession>
    <name>A0A812ENG5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_75854</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005475">
        <property type="protein sequence ID" value="CAE1326278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ENG5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1326278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="238" mass="25717" checksum="73AD93DA92898783" modified="2021-09-29" version="1">MKTPPPKPGVGNLLLTRHHKYSTSVSLFLSLSLSLLLSLSLLLSFACSLSCFLSCSLSNVLSLALSPSLALSLLLSLSLSYSLWLSFAPCLLHSFSLSLVLFLTVSLSIAVFLTLSLAPFLTLSLSLALFLSLSLTLFLTLSRSLSHSLSRSRSHSLSLALFLTLSIALFLTLSLLISFFLSCSLSHSLSLLLSFSLSLSLLLSSSLSLSLYVCIGLLLCLIGHFVFSLICLYMPMYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EQE3</accession>
    <name>A0A812EQE3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SPHA_80471</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005599">
        <property type="protein sequence ID" value="CAE1331164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EQE3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023616">
        <property type="entry name" value="Cyt_c_oxase-like_su1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000298">
        <property type="entry name" value="Cyt_c_oxidase-like_su3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50855">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50253">
        <property type="entry name" value="COX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="282"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="378"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="408"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="464"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="518"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="545"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="573"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="603"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="629"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="657"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="691"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="727"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="756"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="788"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="816"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="845"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome oxidase subunit I profile" evidence="3">
        <location>
            <begin position="143"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="domain" description="Heme-copper oxidase subunit III family profile" evidence="2">
        <location>
            <begin position="209"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAE1331164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="864" mass="106765" checksum="3E7161074A583A76" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ERH0</accession>
    <name>A0A812ERH0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_77222</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005508">
        <property type="protein sequence ID" value="CAE1327788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ERH0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1327788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="170" mass="20593" checksum="0763581B0BEA60CC" modified="2021-09-29" version="1">MSTNQAEKYKISVCVKFKLAVDFFDTQERGYHSYLFFIGLGNFSQLHLFYLCSPLFSIFFVVSSNLFSIFLLLIFLAVFFGSLSFFHYFVFVFLYFTFFFRSFLFLFLCFPPLSFPLYLFLYPLFSFPRDFCFRSFSFLTLFSLFLFLNFFFYFNAYIFFPYICNHSIFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ERM5</accession>
    <name>A0A812ERM5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_77851</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005524">
        <property type="protein sequence ID" value="CAE1328309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ERM5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1328309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="261" mass="31905" checksum="7B348E7BA542BF7E" modified="2021-09-29" version="1">MILSDPPPLLVIHTVKSVKLFSSFCFLSFHFSFFPSFLSFSFFPSFLSFSFFPSFLSFSFFPSFFSFLFFLFLSFLPFFLFSSSFLSFFSFFPFFSFLSFFFFLFSFFFFLSFLSFLFFPFFSFPFLSFFLPFLSFLSFPSFLSFLPSFFFFSSFLFLFFLSFFFFPFFFFFLFFFFFLSFSFLPFLSFPSFFFSSFLFFPFFFFPFPFFSFPFLFSFFSFLSFLSFFFPFFFPSFFPSFLSFFFPAKPSGCRLGRRFEHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EVP1</accession>
    <name>A0A812EVP1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_78595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005544">
        <property type="protein sequence ID" value="CAE1329015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EVP1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="339"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="378"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1329015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="406" mass="48566" checksum="01F9063298DD1BD7" modified="2021-09-29" version="1">METGEQKKKKETGRDEIVKLGIVSYSLFPTLTFAFFLSFFLSLFLSFFLSFFLSYRLPISFIFFLSFLFFLLSFFNFLTPFSFILSNLFLFSFFLSFFLFLLFLSNLFLSCFLIAFLYFFLSFFLPLFIYLLSPSFFFFLSNLFLSSFFLSFFLSYSLSFSFFFFLTSFFLPYHLPFSFPFLTSFFFLSFFFLSFFPLFFLCFFFLSKLFPVLSFIFLHFSNTFFFLPFKPLSSFFLSKHFPFSFFFLSKIELFLLSSFPSNLFPFSVFYLFLTSFSFFLSFFLSFFLSFFLSVTHRIFLDLPQVNILSFFLSFFLSFFLSFFLSVTHRIFLDLPQVNILSFFLSFFLSFFLSSFTRVFAFLMGMCLDSSSFESYDKWNVYCFQSALLAVLITNPFSSYQLVLLTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EXH2</accession>
    <name>A0A812EXH2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Troponin I,Troponin I 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_78956</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the troponin I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005555">
        <property type="protein sequence ID" value="CAE1329511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EXH2"/>
    <dbReference type="OrthoDB" id="371899at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005861">
        <property type="term" value="C:troponin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006936">
        <property type="term" value="P:muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001978">
        <property type="entry name" value="Troponin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050875">
        <property type="entry name" value="Troponin_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038077">
        <property type="entry name" value="Troponin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13738">
        <property type="entry name" value="TROPONIN I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13738:SF1">
        <property type="entry name" value="TROPONIN I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00992">
        <property type="entry name" value="Troponin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90250">
        <property type="entry name" value="Troponin coil-coiled subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="34"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="285"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="38"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="302"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1329511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="311" mass="36867" checksum="D5AABBCEB80EDA2B" modified="2021-09-29" version="1">MCLSIYNCNIRRMFSCFPSNATFIRSNNIDTAAAAAAEEARRQQEAEEAARQAAEEERRQQEAEERRRREEEEREKREAEEALRKIEDEKRAAEEAEKRKIEEEKQKAEEAERKKREAEERRKREEEEREEAERKKRQEEAARRRQEEEEKKKKGKRKGLGGLSPEKKKLLKKLIMQKAAEDLKNEAKRKAEERENFINSRVEPLATDGLNEAQMQDLVKKLHGKMAELEEEVYDWEFKLRRQEFEINDLTLKVNDTRGKFVKPVLRKISKTEAKLAKLERTKKDDFRTTLKSSGHKHDKIEEEEAPAEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EXN8</accession>
    <name>A0A812EXN8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_79516</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005570">
        <property type="protein sequence ID" value="CAE1330178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EXN8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1330178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="216" mass="26016" checksum="4CB28308D25957FC" modified="2021-09-29" version="1">MRPTNTFFQQGREFNLSSPLISSSSSFSMIFSSSFFSYFYYSPFLYTIFSSFFLFLSFQYLLPYNFFYSFSMIHFSFFFFFFFIFSVSSPLNLLHSFSFFSSFFFSIFSLFLLLLFFLIFLFFSSFSIISTTTPITINTIIATLSFFFLFSFHIFFLFSMIFLLLLLLLLLLLLLLLFISFLFFSMITFLDTSFLLFFFFNFSLIFSSFQYYSYYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812F1D1</accession>
    <name>A0A812F1D1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_80912</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005613">
        <property type="protein sequence ID" value="CAE1331768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812F1D1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1331768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="315" mass="35302" checksum="E711D70CD4EB0825" modified="2021-09-29" version="1">MLFFRLTCPSSSPFCPAFLLPSPHSIFLPSLSFLPPSVLPFTLSSSLLSFFSFPFLISLFFPLLCHNVTHPSYCFPYPHSLSPSPASLFIPFHPPSLSLHQIYLPTFSTYLLCISSYSLCIHFLSLSLFPPHLFSLVFSTPVLSLFTRSLSLHTCSLSLSLHTRSCLLSPHLFTFSISLHQIISPLPLTLPNYSVFLPTLSPHLFSLSFSTPVLSLFLHTCSLSLSPQPVLSLSLHTRSCLLSPHLFTFSLSTTCSLSLFLFTHSLPLCLSPHPFSLFISLYTHSLFLHTFLLLLSPPFLSFSPHPFTLSFYPYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AL51</accession>
    <name>A0A812AL51_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_1093</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000029">
        <property type="protein sequence ID" value="CAE1142639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AL51"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1142639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="202" mass="23684" checksum="BB9ABDA63620BAE3" modified="2021-09-29" version="1">MFYTVSTFLSVSSAILLCFFSFVCFVFFYHFHSDLFFLLVFVRHLIIMFLLFLLLLSSSLANHFLHCGFFLLILVFHLLHSVFSSFLFESAMFFFCYFQLLLSSHLCIYIFHRIFFFIRHSSSICLTVQSIFFSAYCSNIFFLHLSMTSSSTLNLYSYSFSSFILFSSSQFLPSPSPVSLIPQPSPSLYSFSFYIFLYTHSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AN95</accession>
    <name>A0A812AN95_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_2042</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000058">
        <property type="protein sequence ID" value="CAE1147161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AN95"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1147161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="308" mass="37922" checksum="91730D9D5304C61E" modified="2021-09-29" version="1">MSFHYFFCSFFFLAQPIVFLSFFSFLSFSFFLSFFLSFFIFFFFIHFLYLLCFLFLLFYFFLFFFPLIPFYASFLIPFPSSFLESTDCAFFHFFSPSEFYRFFILFSFLSFFLSFFLSFFLSFFMSHLFLFMHFFFLLFPSSFIHFFFLSFSFFFLSSYVFYVPSFPLHAFLLHHLPIFFLSFFLSFFLSSLNYSSPYSLFIYLLHYCFFNRSLPFLSLIAFYSFFLSFFLSFFLSFFLSFFPYMPLYLFIIYEFIYPCLSIIYLSIYLSIYLSIYLSIYLSVPIYQTVSLSFFIYLFYQSIYLSIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812APR4</accession>
    <name>A0A812APR4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_2873</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000083">
        <property type="protein sequence ID" value="CAE1150084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812APR4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1150084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="270" mass="31049" checksum="E821B1598620CDE1" modified="2021-09-29" version="1">MTPTRDNTVFFFPIKYSSSFYSAFSTDCLSLWLRLHLQLHPQRPCFFRASYSRPDFVFTLSSSFDISPLLSLSLLSYYFSLSLSHDLFRRYFTSLPTPRTPATVYIPLLLFLHQISNFTFPPTTNYLSPSLEMNPSLFCSTSSIAVLNTFFYFARLWPPMLCSMSVPIYLSIYLSIYLSILVIYLLCVDIYLSMIYDIYLSIYLSSDFPSASLLTITPPRCAYLSLSLSLSLSLSLSLSLSLCWLQEPSIYLSIYLSIYLSIYLSIYLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812APX0</accession>
    <name>A0A812APX0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_4458</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000141">
        <property type="protein sequence ID" value="CAE1155437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812APX0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1155437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="266" mass="31181" checksum="A299950CA79F9B0D" modified="2021-09-29" version="1">MSHITRLDILISIEGIKTHFIFPENKYYHVSIQKLSITYLKFGCSVYLSIYLSIYLSIYLSIYLSIHRHLPLCSFTIDVSIYASINRYLLFCSLSIYLFVAPASNTRELHRHLPFWSFSIHVSIYASINRYLSFCTLSIYLSIYLSNHRHLPFWSFSIHVSIYASINRYLSFCTLSIYLSIYSIHVTQYLNTTLHDRSDGISGQTDRVFLRWPTRHPNHMPCDFFLCRYVKGLLNMPIPLTRDVDDLNIRITEALTTINNAMLCRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AS11</accession>
    <name>A0A812AS11_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_4164</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000129">
        <property type="protein sequence ID" value="CAE1154339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AS11"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1154339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="172" mass="19683" checksum="AE6DE08D78E79278" modified="2021-09-29" version="1">MIHKTSGSILSPPTLAITESTGPTKNLSIYLSIYLSIYLSIYRTLILSYLSLSLYIYNILFISIYLSIYLSIYLSIYLIVPLYIYLSHSDNYLSIYLSIYLSISLIVSIYVYLSHSDSTISNSDTIYLSIDLSHSDTIYLSIYQSVSSYLSIYLSIYLSIYLSVFSTVKRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ATA4</accession>
    <name>A0A812ATA4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_4022</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000123">
        <property type="protein sequence ID" value="CAE1153738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ATA4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="314"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="350"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="378"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="406"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="430"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="458"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="536"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="569"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="613"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="645"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="672"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="702"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="730"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="760"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="792"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="825"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="905"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="932"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="963"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="993"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1018"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1093"/>
            <end position="1113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1153738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1181" mass="135858" checksum="60A9803F2D664520" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ATK3</accession>
    <name>A0A812ATK3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_4774</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000155">
        <property type="protein sequence ID" value="CAE1156428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ATK3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1156428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="247" mass="28195" checksum="B71676E2BF65283A" modified="2021-09-29" version="1">MKAFENILSSLSVSFHQHHCHRCSLLLFLSFSLSPYQDCNHCRLRHHSFLISSTNRPALDPLLLLHCNIAYYHICFQKSISLNSLSPGFLSSSASSPTLSPPLLHPLFLLRFFTHSFSSTHSFSSTHSFSSTHSFSSTHSFSSTHSFSLFLLHSLFFLHSLFFTLSPPLTLFHSFSSTHSFSLFLIHSLFFTLSPPLTLFHSFSSTHSFSLFLLHSLFFTLSPLPPPLFFYHSLFLTLFMSLKLFTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AZE2</accession>
    <name>A0A812AZE2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_7533</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000241">
        <property type="protein sequence ID" value="CAE1163027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AZE2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="364"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="388"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1163027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="411" mass="47130" checksum="5A27CA6DA15E4FC0" modified="2021-09-29" version="1">MFLSIFLSIYLFYLFISISFLSYLSIYLSIYSNVFTSIYLSLFLSIYFTSYRSLCLSVCLSIYLSSKYTYANSSQVTGVPRGNNHSSINIYLSIYLSIYLSIYLSMNLIRSYLSIYLSIYLSIYLVCFYLSIYLSIYLSSLFISIYLFNLVFSLSIYLSISISLFLSIYLSIYLVCSLSIYLSISRDKCIDGWAYCIFHQGCITDQSISIVRSSELIQFPLISLSNSLSIYLSHHLSLSTYISIYLPISLCLSFSLLFISIYLSIYLSIYLSLLIFIYLRISIVNLTFLPPIPFSSSHFPTLSLSLSLSSPIITLPPYVIPSPLFSSVLLLTGSRLITFSPRPSSDFDGVSLFTTRLSTRFMSIYLSIYLSIYLSILVWLYLFNYLSISVWDLSIYLSIYLSIYLSIYLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B2K5</accession>
    <name>A0A812B2K5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_10171</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000328">
        <property type="protein sequence ID" value="CAE1168683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B2K5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1168683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="295" mass="36901" checksum="7EC71A42C5236200" modified="2021-09-29" version="1">MLFFPIFTFLFFHLLFFFHLFCFSPIFTSFLFFFSIFTSFVFFSIFTSFLFFLIFTSFLFFLIFTSFLFFFNLYFFSVFFFKTLLLFCFFFQSLLLFCFFPSFSFLFFFSIFLFSVFFFNLFLFCCFFSIFYFLFCFLIFTSFLFFFFTCFSVFYLYFFSIFSTFTSFLFFHLYLFSVFPSLLLFCFFIFTSFLFFHLYFFSVFSSLLLFCFFIFTSFLFFHLYFFSVFSSLLLFCFFIFTSFLFFFQSLLLFCFFFQSLLLFCFFFQSLLLFCFFFQSLLLFCFFNLHFFSVFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B3C1</accession>
    <name>A0A812B3C1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_9866</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000313">
        <property type="protein sequence ID" value="CAE1168005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B3C1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="328"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1168005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="357" mass="43768" checksum="C37B1BA845231B65" modified="2021-09-29" version="1">MRFFFLFIFHLLSFFFYSIFSFLFFLFFSLSFFFFFLFPLYIFSSIFSLLYFFSVFYFTSFYSFPLVFFFLFLFIFPFVFLSFPFSFSISLFLLFFFSFFVRFSFPFAFLSFFFSIYLFPLFILFPLLSSFPFSLFFFFLFYSFFFTFFFSFFSIFLFPILFFFLYFLLFLFLYFSFSSFYSFSLLSSFPFSLFFFFLFLFFFFSFFSFSLFFPLFPFIYFSFIFFHSRLLSCKRRFSPLRYAFISHFATDSNYRLVTVFFSFFFLSLSLSIQAPTSIYLSIYLSIYLSIYLSIYLSQSVRIYLSIYLSIYLSIYLSIYLSIYLSITVVLLLVFVNLSISHVCSLSIYLSIYLSIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B451</accession>
    <name>A0A812B451_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SPHA_9931</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000318">
        <property type="protein sequence ID" value="CAE1168252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B451"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF82">
        <property type="entry name" value="KP78A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAE1168252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="165" mass="19192" checksum="BEF49E530021CD47" modified="2021-09-29" version="1">MENIMLDEKKKNIKIVDFGLSNTFSKDNLMKTHCGSPEYAAPELFNPSEKYGPEIDIWSLGIIFYAMLVGKLPFTTPSSDQFRRRELQQQIEKGLVNSHFKEMVHLSPECKELINKLIEPSPSLRLPLMDVEIHPWVTLEAKFPFHPFQSFIKDKPMRNQVIMQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B725</accession>
    <name>A0A812B725_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_11374</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000376">
        <property type="protein sequence ID" value="CAE1171068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B725"/>
    <dbReference type="OrthoDB" id="77878at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017171">
        <property type="term" value="F:serine hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008547">
        <property type="entry name" value="DUF829_TMEM53"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20908">
        <property type="entry name" value="LD15586P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20908:SF1">
        <property type="entry name" value="LD15586P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05705">
        <property type="entry name" value="DUF829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1171068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="321" mass="36814" checksum="E97126018A0479FF" modified="2021-09-29" version="1">MAGFAVRSRLFLFSSSATRSQFLPTRPLLLCRLSNSCTVGENMELCKSESPLTYHSPQGSGKPLVLMLGWLLARTKHLTKYTNIYASKGFDVLQIRVTPSQVLWPVRAQGFIEKIFKVLEQEDCRNQPILVHGFSVGGYIYGEMLVKMQTEPEKHANLRHRLMGQIFDSPVDKDRVAYGMSQNLVKHPLLQFLLFRMLEQYLIVFRASVADHFTRAQNAFLQNTMSLPSLLFFSYMDPIADPQIIEATINKWTGRGIPVFYKSWSDSKHVSHLQQYPEEYIEMLLNFLECLPLVPSDAHVCTKYEEITKPRLQERSSSSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B8Z7</accession>
    <name>A0A812B8Z7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CECR1</fullName>
            <ecNumber evidence="2">3.5.4.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_11368</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.4" evidence="2"/>
    <dbReference type="EMBL" id="CAHIKZ030000376">
        <property type="protein sequence ID" value="CAE1171080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B8Z7"/>
    <dbReference type="OrthoDB" id="7202371at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="334"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="370"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1171080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="425" mass="52040" checksum="C20754AB95824F95" modified="2021-09-29" version="1">MFVIYLSIYLSIYLSIYLSIYLSLLTIYLSIYLSIYLSIYLSHLFIIYLSIYLSIYLSIYLSLSLSLSLSIYIYIYIYIYIYISVHYLSIYLSIYLSIYLNMFIIYLSIYLSIYLSIYLSKTTPSGLLHIHDFALTSIQWLVSYATYLPHCYFCQYQRRRNYLFTFSVNRPVSTQDLFILCFLFVSFFLFPFLVSRFFYFVYGIFLLACFLSFVFPPFLFTHFYFQMVYFCLLVLFVCFFVCLFVSFHIFIFPFFIFPWFIFASCFLSFFSHFYFPIFYFSMVSFVSHFYFPIFYFPMVHLCFLFSFFLFPFLFSHFLFHHGSFLLASFDSFPIFIFSFFIFPWFIFACLFPFFRFTFLFSHFLFSYDSFLLACFRFHILIFHFLFSHGSFCLLVFFFAFPFLFFHIFIFLVFFSFFIFPFFVFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B9D0</accession>
    <name>A0A812B9D0_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Tripartite motif-containing protein 59</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SPHA_15553</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000542">
        <property type="protein sequence ID" value="CAE1224903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B9D0"/>
    <dbReference type="OrthoDB" id="6105938at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060340">
        <property type="term" value="P:positive regulation of type I interferon-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF299">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="31"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="7">
        <location>
            <begin position="124"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="200"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAE1224903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="338" mass="39998" checksum="971F3035D5851C01" modified="2021-09-29" version="1">MVPKKVESAEKLRRRNLIFDEEHFEDVFLRCLICRDVFNESEKLPKTLPCHHSFCLQCFLEMFRVEGEYRQSLSSAFRGMPRAVKIQCPTCRDSIIASEEDLRRLPNDHTVLELLSFVHETGITDIAYCTKHQLQPLNFFCEPCAIPVCSDCTVLDHKELNGHQVMNMEEALNKYTPIINETINEMERRKKEHLMRRTHIEQAMEKLAEMETQVTDEIKLTFQKLREVIDEREREILSMSEQEMERKRRNLMENFRKIIEREECILSQMKILETARQENDISQMFNSHQSAQDTLSSPLHLPHITNDDFGVSFHYEIYKQKRVIQDLTNFGHLMVQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BDC8</accession>
    <name>A0A812BDC8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CAPN15</fullName>
            <ecNumber evidence="2">3.4.22.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_14580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.-" evidence="2"/>
    <dbReference type="EMBL" id="CAHIKZ030000499">
        <property type="protein sequence ID" value="CAE1177322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BDC8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1177322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="192" mass="22100" checksum="517BAC251C08C0EF" modified="2021-09-29" version="1">MRESFGVFSWVTAAVAVSRPSAAVVGAVLLVCCRKVWFARRRSFFGSQEGVRLLCHKKLFPPTPEEPTSESSALDEPMRNELSETPEEITTEEALETIPLRRSTRQKRPALHCHLCDLEIREECNEHARKRPRTQPLRSVVRRQQLWVPFCSFAVVKFGSQEGVRFFRSQEGVRLLCHKKLFFPPFSLTDII</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BDN9</accession>
    <name>A0A812BDN9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_13747</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000461">
        <property type="protein sequence ID" value="CAE1175619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BDN9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1175619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="190" mass="22464" checksum="68568DAC7500EA6C" modified="2021-09-29" version="1">MHLSDFLSIYLSIYLSLFMSNYLSIYQSLFMSIYLSIYLLSSYLSIYLCSCRTIYLSISVHVDLSIYLSIYLSIYSILFMSIYLSIYLSIYLSIYPSLILSLSLSSIYLSIYSLFHSLIYLSLSLSLYLIYIYIYIYLFISIYLSIYISIYLSLLDLDLSIYLSIYLSIYLSIWRIIAVFFLFGHPYLYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BEJ0</accession>
    <name>A0A812BEJ0_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Transportin-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SPHA_18523</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Farmed</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Importin, which transports target proteins into the nucleus. Specifically mediates the nuclear import of splicing factor serine/arginine (SR) proteins, such as RBM4, SFRS1 and SFRS2, by recognizing phosphorylated SR domains. Also mediates the nuclear import of serine/arginine (SR) protein CPSF6, independently of CPSF6 phosphorylation. The nuclear import process is regulated by the small GTPase Ran that partitions between cytoplasm and nucleus in the predominantly GDP- and GTP-bound form, respectively. Importin associates with target cargo proteins in the cytoplasm, and the competitive binding of GTP-bound Ran induces the release of cargos in the nucleus.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with (GTP-bound) Ran. Interacts with (phosphorylated) SFRS1 and SFRS2; leading to their nuclear import. Interacts with NUP62. Interacts with RBM4. Interacts with CPSF6, promoting its nuclear import.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000668">
        <property type="protein sequence ID" value="CAE1232350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BEJ0"/>
    <dbReference type="OrthoDB" id="435593at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000079">
        <property type="entry name" value="transportin-3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051345">
        <property type="entry name" value="Importin_beta-like_NTR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057941">
        <property type="entry name" value="TPR_TNPO3_IPO13_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057942">
        <property type="entry name" value="TPR_TNPO3_IPO13_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058537">
        <property type="entry name" value="TPR_TNPO3_IPO13_4th"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12363">
        <property type="entry name" value="TRANSPORTIN 3 AND IMPORTIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12363:SF42">
        <property type="entry name" value="TRANSPORTIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24138">
        <property type="entry name" value="TPR_TNPO3_IPO13_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24140">
        <property type="entry name" value="TPR_TNPO3_IPO13_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24139">
        <property type="entry name" value="TPR_TNPO3_IPO13_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exportin-1/Importin-beta-like" evidence="12">
        <location>
            <begin position="101"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00060097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00063116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00067328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAE1232350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="985" mass="110222" checksum="EE823E3ADA2A93B0" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BF67</accession>
    <name>A0A812BF67_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Apolipophorin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SPHA_18901</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000683">
        <property type="protein sequence ID" value="CAE1233317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6484170at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045735">
        <property type="term" value="F:nutrient reservoir activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.230.10">
        <property type="entry name" value="Lipovitellin, beta-sheet shell regions, chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.80.10">
        <property type="entry name" value="Lipovitellin-phosvitin complex, chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.50.20">
        <property type="entry name" value="Lipovitellin. Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.20">
        <property type="entry name" value="Vitellinogen, superhelical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015819">
        <property type="entry name" value="Lipid_transp_b-sht_shell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009454">
        <property type="entry name" value="Lipid_transpt_open_b-sht"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011030">
        <property type="entry name" value="Lipovitellin_superhlx_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015816">
        <property type="entry name" value="Vitellinogen_b-sht_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015255">
        <property type="entry name" value="Vitellinogen_open_b-sht"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015817">
        <property type="entry name" value="Vitellinogen_open_b-sht_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050733">
        <property type="entry name" value="Vitellogenin/Apolipophorin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001747">
        <property type="entry name" value="Vitellogenin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23345:SF15">
        <property type="entry name" value="VITELLOGENIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23345">
        <property type="entry name" value="VITELLOGENIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06448">
        <property type="entry name" value="DUF1081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09172">
        <property type="entry name" value="Vit_open_b-sht"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01347">
        <property type="entry name" value="Vitellogenin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00094">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01169">
        <property type="entry name" value="DUF1943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00638">
        <property type="entry name" value="LPD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00216">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58113">
        <property type="entry name" value="Apolipoprotein A-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56968">
        <property type="entry name" value="Lipovitellin-phosvitin complex, beta-sheet shell regions"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48431">
        <property type="entry name" value="Lipovitellin-phosvitin complex, superhelical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51211">
        <property type="entry name" value="VITELLOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0758">Storage protein</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032626293" description="Apolipophorin" evidence="11">
        <location>
            <begin position="17"/>
            <end position="1891"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="26"/>
            <end position="50"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="174"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Vitellogenin" evidence="12">
        <location>
            <begin position="87"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="13">
        <location>
            <begin position="1688"/>
            <end position="1857"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAE1233317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1891" mass="218463" checksum="C732DF624FEF223B" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BFH7</accession>
    <name>A0A812BFH7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_16509</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000581">
        <property type="protein sequence ID" value="CAE1227737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BFH7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="297"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="333"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="375"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1227737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="408" mass="48095" checksum="9CEDB6973A9AA353" modified="2021-09-29" version="1">MIYLSIYLSIYLSIYLSIYLSQSVPIYLSIYLSIYLSIYLSQFIHIYLSIYLSIYLSIYISIYLSIYLSLFPSIYHLSIYLSIPVRSQFIYIHQSQSILSSIHLSIYPSIHLSIYLSPVPYLSSIHPSIHLHLSISPSIYPSIHPSIYLSSIHPVYFIYLSIHPSIHLHPVYYLSISIHLSIHPSQSVPIYLSIYLSVFISIYLSIYLSIIYLSISVYLIPIYLSIYLSIYLSIYLSIYLSIYLSLFLSIYLSIYLSHHIYLSIYLSISSVPIYLSIYLFILSLFIYVLIYSSIYQFIYLSSIYLIYSYLSISFIYLSFLYLSITVYSYYLSIYLSIYLSIYLSIYLSQFIHIYLSISVYSYRSQFIYIYQSQFIHIYLSIYLSIYLSIYLSISVYSYLSIYLSINLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BH46</accession>
    <name>A0A812BH46_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_16698</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000591">
        <property type="protein sequence ID" value="CAE1228096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BH46"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="7"/>
            <end position="26"/>
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    </feature>
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        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
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            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1228096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="214" mass="25660" checksum="C44F5304A988C8A4" modified="2021-09-29" version="1">MQERLQIIDIPLFPFFHFLRWVFSFYTCDNISLKGVFSFYASGGIFLLYFWYYLFKGGIFFLYFWYYLFKGGIFFLYFCTTTIITTTITTAIEPLFVFLSFSHLSIYLSIYLSISICSYSSIYLYLSQFIYIHHIYLSIYLSISICYISYLSIYHLSIYLSIYLSIYLSQFVHIYLSIYLSIYLSICSYLNLFISIYHLISIYLSIYLSIYLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BI12</accession>
    <name>A0A812BI12_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_15982</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000558">
        <property type="protein sequence ID" value="CAE1226363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BI12"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1226363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="291" mass="33975" checksum="43270648DC0C92CD" modified="2021-09-29" version="1">MKRQKLICHSGSFFLSFFLSLLFFFFFLFFFFFLSKCTRYLMSVIQCFALVIYLSIYLSYLLSMNWTIAESIYLSLSIYLSISFFIYLNFHTYQMLLICLSDISIPSRHFDTILPHLLTLHVDSILILHVFPFENPFSFYIPSQFSLSLSLSLSHLFGSTPMTLHLISQQLPFFLFLYFLSTISLPFLTSFSGLSFSPSLNICRMIFFSLFFFTFSGQLLFITRSLSPSLSHSFPSLLKNVSLHSLSLSFYFLFPLSFSLYCLSLSYSVTLIELPLPPFHYFHFLSFSPCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BIJ4</accession>
    <name>A0A812BIJ4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_16249</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000569">
        <property type="protein sequence ID" value="CAE1227054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BIJ4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="303"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1227054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="353" mass="40394" checksum="942868A34FBD5255" modified="2021-09-29" version="1">MKIPAPQRKRTKCDRRHFGACAARSSIYLSIYLSIYLSIYLSIYLSLLSIYLSIYLSIYLSIYLYPVIDTCLLARQATIQKEEGHKRPITDSGAARLASIYLSIYLSIYLSIYLSMYRSISIPFIYLSIYLSIYLSIYIFEVFLFFPSRLFIYTFSSCRFSMMLFIHFSSIICKFNLSSSSSSSSSSSSSPLFFFFFFFNFLLLLLLLLFLLHFSSSSSIFFFFNFLLLQFSSSSSSSSSSPIFFFFFFNFLLLLLQFSSSSSSPSSSSTTTTTTTTTITITTSATLSTSTTSSASFYISSNLLISIYLSIYLSIYLSIYIYIYIYIYHSLLISIYLSIYLSIPLSLFLIVQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BJP9</accession>
    <name>A0A812BJP9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_19981</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000728">
        <property type="protein sequence ID" value="CAE1235921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BJP9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1235921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="152" mass="17351" checksum="375AB627EF5E6729" modified="2021-09-29" version="1">MTLHSFLFLISLKDFLSISLPYSFSLHQSSLKKFSFFFFFSLLLLLFLFFLLTLHFSLPLFLSFPCLSLFLSLSYPLSPTPSLSFSHSFFIPLSPHLSLSLSLFLSFYLSISLYPSLSIYLSSTTSLSHPFSLFPPLFLYPSLSLPLSPLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BM55</accession>
    <name>A0A812BM55_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_18076</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000648">
        <property type="protein sequence ID" value="CAE1231360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BM55"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032380969" evidence="2">
        <location>
            <begin position="21"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1231360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="230" mass="26318" checksum="78236B6EF88F89AF" modified="2021-09-29" version="1">MGDIVHTLLFVFFFLSPTPARDKETNSSFLFSISIFFPSLALSSLFSFASSVPLCPSLFFPSLALSQSFFPSLALSQSFFSFASSVPVFFPSLALSQSFSFASSISIFFSFTSSVPLYFNLFPSLAVFQSFFLHWLCPTLFQYFSFILSSLHNLFSNLFVFTISFLIIFSSLISSLHDLFQNHSLFLLLYFLKTVASHFLLVLFLNIFFLCLLFRIPNYPFFFFFAPEKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BQL8</accession>
    <name>A0A812BQL8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_20396</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000746">
        <property type="protein sequence ID" value="CAE1236699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BQL8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1236699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="237" mass="28224" checksum="32595CBDCC08DCFB" modified="2021-09-29" version="1">MFFPVCLQSNCHRPDGQEIDSVLCLAPVYSLFMYLRLACFLSSFLSFLLVCFVSFFISSFFVLSFFILSFLCSVYLSFFFLCYITLSFFLKLLLLISNIFYCFLSSSFFHFFFFLTFYLSFFLVCLISSLSLSLSLSLYFPLNIFLFFFVTSSFFFSFDPFLFYLLLNLLFVTRRSIYLSIYLSIYLSIYLSIFLYFPIVSSFLIVSYMQSFFFNSFFFSFSTEKLIIDSQMKHYRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BUW8</accession>
    <name>A0A812BUW8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SPHA_27407</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the nuclear hormone receptor family. NR1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001062">
        <property type="protein sequence ID" value="CAE1251155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BUW8"/>
    <dbReference type="OrthoDB" id="6081310at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004879">
        <property type="term" value="F:nuclear receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06916">
        <property type="entry name" value="NR_DBD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050234">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001728">
        <property type="entry name" value="ThyrH_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24082">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00546">
        <property type="entry name" value="THYROIDHORMR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="11">
        <location>
            <begin position="15"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="12">
        <location>
            <begin position="160"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAE1251155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="390" mass="45554" checksum="DD596046780FE875" modified="2021-09-29" version="1">MTDTNGYCTTTESVLPPCRICGEKASGFHYGVNTCEACKGFFRRSLMRKEEYKCPGMSNCEICPGKRNSCAFCRFKKCLAMGMSKEAIKTGRYTLEKRTKDIQEVKRLQQAEACPSPENWDHIQEIEYLICVIIKAHKIYGQDIMFDKEEINKRQTEYYEQYKLKESVFGSLPTISKEEFDSFYHSTGIDLDNRLHLMELYAKSMEESIRRFVNFAKTIPSFTNLTLSDQSSLIKASRFEFWFLGSYRLMNPVLKVATGYNGACYHIEELSRIWDRDFLEAVFSFSACLQKLNLEDDEIGLIRAIIIMSVDRCTLDEPKKVEDIQWKLVNCLDYHLNQKDSTNKKRLAKIFDRLMSLRSLTEWNLKLIHSMKVEWAVFRQNPLLYEILTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BV12</accession>
    <name>A0A812BV12_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_24598</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000921">
        <property type="protein sequence ID" value="CAE1245151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BV12"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1245151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="255" mass="29991" checksum="E31041828C1FE6BA" modified="2021-09-29" version="1">MSTSFIHYKTFGKFSSFIFSFFSFSFLFLLFFSLFLFLFVFICFASTISFFNLFYVLLFFLSFFIPFFPTLISDLHIIIPFSFFFLSPFVCLFVCIFLSFFKLFYIVLFFLLPFASFSSFFFLSFLLLSIYFWLFLSHSLFAPFAAIHFLPIISPTLFLNFSLFPNRPPSFPHSNILAGDLHSICKGFKGHERVNMIALLCAKLLLKTSSFLLPLRHPKGHEIFTCAQTLTHLIYMCIFLRRYTEDSTHNYTQTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BV94</accession>
    <name>A0A812BV94_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nuclear protein MDM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SPHA_23314</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Farmed</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Microtubule-binding protein that negatively regulates centriole duplication. Binds to and stabilizes microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MDM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000863">
        <property type="protein sequence ID" value="CAE1242462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BV94"/>
    <dbReference type="OrthoDB" id="9999940at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046600">
        <property type="term" value="P:negative regulation of centriole replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029136">
        <property type="entry name" value="MDM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32078">
        <property type="entry name" value="NUCLEAR PROTEIN MDM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32078:SF1">
        <property type="entry name" value="NUCLEAR PROTEIN MDM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15501">
        <property type="entry name" value="MDM1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="266"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="401"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="435"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="837"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="267"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="312"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="441"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="458"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="478"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="488"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="506"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAE1242462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="917" mass="103315" checksum="B51E82EE671EE06C" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BY12</accession>
    <name>A0A812BY12_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_24298</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000905">
        <property type="protein sequence ID" value="CAE1244453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BY12"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="279"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1244453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="335" mass="40000" checksum="9F63B783252F5959" modified="2021-09-29" version="1">MSLSGNGILSIYLSIYLSIYLSIYLSLYLSIYLSIYLSISYLSMHLRHFVIYLSIYLSIYLSIILSFYLCILDNTLSIYLSIYLSIYLSFNLSFLSIIQLREFLSIYLSIYLSIYLSIYLSISRFYINLLFCSYLSIYLSIYLSIYLSMSSFYLSIYLSIYLSIYLSIYLSLVSILIFYFVHIYLSIYLSIYLSIYLSISRFYINLFNLFIYIYSYFYSSIYLSIYLSISIYLSIYLSQFISIYLSIYLSIYLSIYLSIYLSIYPCLFISILLSNFSLLYIPSLSLYFSLFIYISVYNTYFEQSIYLSIYLSIYLSIYLSIFLSIYFQYMLQIYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BYA8</accession>
    <name>A0A812BYA8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_24442</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000912">
        <property type="protein sequence ID" value="CAE1244729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BYA8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44592">
        <property type="entry name" value="NUDIX HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44592:SF3">
        <property type="entry name" value="SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1244729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="229" mass="26389" checksum="7AEDEB82CACC562F" modified="2021-09-29" version="1">MEISLSLSLSLSLSLSIYLSIYLLDQIYISNNWVSAFNIYLSIYLSIYLSIYLSIYIFIFLCIYISISVNISLYMSLPPSLSLSLSLSLSIYLSIYLSIYLSIILSVYVSICLFLLISLSPSISIYLFLSISIYLSIYLSIYLSIYIYIYMPLLIYHFIHLCMYISISVNIYLSIYLSIYLFQFHIIYLAICLVIFFLFIVLCYTLSVSLSISPSLSLSLSFYACEHPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BZ85</accession>
    <name>A0A812BZ85_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G-protein coupled receptors family 3 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SPHA_25391</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000960">
        <property type="protein sequence ID" value="CAE1246913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BZ85"/>
    <dbReference type="OrthoDB" id="425344at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050726">
        <property type="entry name" value="mGluR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24060">
        <property type="entry name" value="METABOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="292"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="322"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="7">
        <location>
            <begin position="88"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAE1246913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="389" mass="43595" checksum="F6D24B8A3FEB79A0" modified="2021-09-29" version="1">MFEFYISFFFQIKLSENLKSIDNKNVEIVVASCENCQCANDVKISTSAFSNGNAGTAQSSVSFISLGELTSRIRNYFHYENNKRIYDWSLWAIIVAGFTTVGIIVTLILFFYLLIAYPIRGGTTPLGFIFIIGIMGIYGVNFAFFVPASLVTCAARRFCMGVVYAICFACLLVKAVDNWRTGDSNYDKKRYKRLSSSLCLVLIAVAIILMQVIIPVEWLLLVKPSSVNLLSVNPGANSVLYQEHDFSWCTPVGSYDSGLALSFIFIIILDLVTILFGALAWDSEKNSFESRWIVIACLCTSGCFLVWMVVSTLANPVFRDPAVAIGNFVNATALLIVIPFRKVILLVMAKRNEKMYPNDMSHIDDIYHKPASYMEPVYFEKNNWNNSGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BZH8</accession>
    <name>A0A812BZH8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SLC16A14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_25538</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000967">
        <property type="protein sequence ID" value="CAE1247202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BZH8"/>
    <dbReference type="OrthoDB" id="6286464at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF284">
        <property type="entry name" value="EG:103B4.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="281"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="319"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="351"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="375"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="409"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="438"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="499"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="524"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="559"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="589"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1247202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="625" mass="69036" checksum="48B574C9A6143080" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BZL0</accession>
    <name>A0A812BZL0_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein YIPF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SPHA_28471</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the YIP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001114">
        <property type="protein sequence ID" value="CAE1253516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BZL0"/>
    <dbReference type="OrthoDB" id="411251at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045231">
        <property type="entry name" value="Yip1/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006977">
        <property type="entry name" value="Yip1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236">
        <property type="entry name" value="GOLGI MEMBRANE PROTEIN YIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236:SF1">
        <property type="entry name" value="PROTEIN YIPF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04893">
        <property type="entry name" value="Yip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Yip1" evidence="7">
        <location>
            <begin position="109"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAE1253516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="265" mass="29970" checksum="DBFAD42B0EA50A25" modified="2021-09-29" version="1">MRMREFDYTGSISMMADVDFHSNQVGKGLEEPLLIPDPKASGDHHSQHAKGEMNMNDVPLEGDITLPKLFEEDQEDELSTLDEPVKDTILRDLKAVGVKFFHVLYPKQSKMLLREWDLWGPLILCVFLALMLQSSPEDLDKKQVGGPEFSEVFVIFWAGSVIVTLNSKLLGGNISFFQSVCVLGYCVSPLALSLLICRLILTFSNPNTVLFVIRFLVVCLAFGWSTFASTAFLANSQPYNKKYLAMYPIFLFYFVISWLIISHTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C0U2</accession>
    <name>A0A812C0U2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_27336</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001055">
        <property type="protein sequence ID" value="CAE1250962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C0U2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1250962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="259" mass="28835" checksum="824417313E5006AB" modified="2021-09-29" version="1">MRAVRHKSAIRKSPSSLQSVRSQKLYHPGRVTQACNQNESLESTIRTEPKAFPSKQGYSGLNQNGSFVSTVRADPKALPSEQGYSGLQSERVLRFYNPCGAKSFTIRAVIHRSAIRTSPSSLQSVRSQKLCHPSRDTQCRQIYHPNRSPKVCILIGSLGSAIRTSASGLPYDQRPSVLPSGRVTRVYNRRGAGRFHRRAGILRSEIRTGPSDIHTVRDLTFRFSLLSLSLSLSLSFPNFSLFLISLFLFLIPLSLSLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C3G1</accession>
    <name>A0A812C3G1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CALCR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SPHA_28855</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001137">
        <property type="protein sequence ID" value="CAE1254261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C3G1"/>
    <dbReference type="OrthoDB" id="16753at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004948">
        <property type="term" value="F:calcitonin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1240.10">
        <property type="entry name" value="GPCR, family 2, extracellular hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050332">
        <property type="entry name" value="GPCR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003287">
        <property type="entry name" value="GPCR_2_calcitonin_rcpt_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036445">
        <property type="entry name" value="GPCR_2_extracell_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001879">
        <property type="entry name" value="GPCR_2_extracellular_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017983">
        <property type="entry name" value="GPCR_2_secretin-like_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45620:SF42">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR SEB-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45620">
        <property type="entry name" value="PDF RECEPTOR-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02793">
        <property type="entry name" value="HRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01350">
        <property type="entry name" value="CTRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00008">
        <property type="entry name" value="HormR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111418">
        <property type="entry name" value="Hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00649">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50227">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 1" evidence="4">
        <location>
            <begin position="29"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAE1254261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="170" mass="20126" checksum="C483509E5AE28FC8" modified="2021-09-29" version="1">MISFFFSSFQNEKMSSEKQLFLLEKAKQECYTRMNTEPPKFSNGLWCNRTWDGIMCWNDSPASTVMKQQCPSYIHGFAKNNFAYKKCTNSGTWYRKAETNKTWTDYTSCIDKLSTGIPVEFFFFSLFFFILLFSVLYSCKFLAYSFSYSIFFFPPFFSFSLEFSTCYFIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C427</accession>
    <name>A0A812C427_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SPHA_27923</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001099">
        <property type="protein sequence ID" value="CAE1252334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9998011at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02897">
        <property type="entry name" value="A2M_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000001">
        <property type="entry name" value="CD109 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1930:FF:000001">
        <property type="entry name" value="CD109 isoform 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.130.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1930">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.690">
        <property type="entry name" value="Alpha-macroglobulin, receptor-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009048">
        <property type="entry name" value="A-macroglobulin_rcpt-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036595">
        <property type="entry name" value="A-macroglobulin_rcpt-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050473">
        <property type="entry name" value="A2M/Complement_sys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011625">
        <property type="entry name" value="A2M_N_BRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041813">
        <property type="entry name" value="A2M_TED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047565">
        <property type="entry name" value="Alpha-macroglob_thiol-ester_cl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011626">
        <property type="entry name" value="Alpha-macroglobulin_TED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001599">
        <property type="entry name" value="Macroglobln_a2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019742">
        <property type="entry name" value="MacrogloblnA2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002890">
        <property type="entry name" value="MG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041555">
        <property type="entry name" value="MG3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040839">
        <property type="entry name" value="MG4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412">
        <property type="entry name" value="MACROGLOBULIN / COMPLEMENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412:SF171">
        <property type="entry name" value="PREGNANCY ZONE PROTEIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00207">
        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07703">
        <property type="entry name" value="A2M_BRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07677">
        <property type="entry name" value="A2M_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01835">
        <property type="entry name" value="MG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17791">
        <property type="entry name" value="MG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17789">
        <property type="entry name" value="MG4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07678">
        <property type="entry name" value="TED_complement"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01360">
        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01359">
        <property type="entry name" value="A2M_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01361">
        <property type="entry name" value="A2M_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01419">
        <property type="entry name" value="Thiol-ester_cl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49410">
        <property type="entry name" value="Alpha-macroglobulin receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00477">
        <property type="entry name" value="ALPHA_2_MACROGLOBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0646">Protease inhibitor</keyword>
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            <begin position="400"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="441"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="474"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="504"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1252677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="528" mass="65203" checksum="1671D3F9EFD54C43" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CBR7</accession>
    <name>A0A812CBR7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_31345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001284">
        <property type="protein sequence ID" value="CAE1258691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CBR7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1258691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="272" mass="32537" checksum="2F8067724AE5745A" modified="2021-09-29" version="1">MNNLSQPFDICLSFPYIYLSVILSVISLYLSLCHFIISIYMFFIISVISLYPYVISLYLSFHYIYLFIISVISLCLSFHYTYLSFNYMSFYLYVISLICHFIISVFSLYLFFHTYFFSLCLSFLYLCISFSFHYIYLCIYHSLPYIYLSGISLYLSLFSLYLFIYHSFHYIYPSMYLSFPYINLPISFFSYLFSDNPSIYACLAPYLPDYLSIYLSIYLSIYLSIYLSIYHFLLLVCSYLSIYLSIYLSIYLSIYLSIYLSYILPCPIYLCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CDV5</accession>
    <name>A0A812CDV5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_31654</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001304">
        <property type="protein sequence ID" value="CAE1259347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CDV5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="315"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1259347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="363" mass="42979" checksum="633D133C93A6A757" modified="2021-09-29" version="1">MVQKCIFIIIYFKTPYTPIEIYLSIYLSIYLSIYLSHYIHYLSIYLSIYLSIYHVFPYLSAYIASYVDSSDRITIYLSIYLSIYLSIYLYIYIYMASGFKIPSTIGGAFSRSDGFRFPRRCLILIHEDMSRPCQGHLGQLWRPSAETFKRKLGNVLKSFFLSFFLSFFLSFFLSFLIFLLFFLYIGFNISSFISIYLSIYLSIYLSIYLSIYLSKTVHIYLSKTVQESIYLSIYLSIYLSKTVHIYLKQFISIYLSIYLSIYLSIYLKLFISIYLASELYLSIFVLIYLSISVFSLSIYLSIYLSIYLSIYLSQFFYYLSIYLSIYLSIYLSIYLSISVFSLSIYLSIYLSIYLSIYLSTKVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CFN4</accession>
    <name>A0A812CFN4_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SPHA_33346</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001394">
        <property type="protein sequence ID" value="CAE1262667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CFN4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51225">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="289"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="348"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="381"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="416"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="445"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="477"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="504"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="7">
        <location>
            <begin position="180"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAE1262667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="523" mass="65554" checksum="15520EE9F0812CB6" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CKF5</accession>
    <name>A0A812CKF5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_38786</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001779">
        <property type="protein sequence ID" value="CAE1274312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CKF5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="296"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="331"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1274312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="361" mass="39764" checksum="254407D971B9EB85" modified="2021-09-29" version="1">MSPFSVFSLGSTPFTFLLISLSLSLSLSLSLSLSFLLILLLFLNMSPYSFFCLLSGIQTPLHSLLIALSLSLSLSLSLSLSFSFNSASLSQHVSLFFFVFSLGFKSLYIPPNSLSLSLSLSLSLSLSLSRFLLILLLFLNMSPYSFFCLLSGIQTPLHSLLIALSLSLSLSLSLSLSRFLLILLLFLNMSPYSFFCLLSGFHTPLHSLLIALSLSLSLSLSLSRFLLILLLFLNMSPYSFFCLLSGFHTPLHSLLIALSLSLSLSFSLSLSLSFSFNSASLSQHVSLFFFLSSLWVPHPFTFLPNCSLSLSLSLSLSFSFNSASLSQHVSLFFFLSSLWVPHPFTFTPNCYFSLSRLSPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CL32</accession>
    <name>A0A812CL32_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_41051</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001962">
        <property type="protein sequence ID" value="CAE1278115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CL32"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="296"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="321"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="391"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="439"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1278115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="472" mass="56879" checksum="B2675E1D11B1BB53" modified="2021-09-29" version="1">MHKTILSLSFFLSFFHSFFLSFFLSLSPSVFHLYFPSFIFSPFHLIDNHLFFSFFFPFRTFIAFFLSFYLPFNLVFFYLSYFLFFLSFFLSSWYSFFFSFFLFSCLGVLSFFLSFFLSFFLSFFLSFFLSSRRSFFLSFFLVGVLSFFLSFFLSFFFFSAFFFFLFFVTVQSFFFLFFSIFLSFFFSFFLAFFLSFFLIFSFDFLSFFVLRSFFQSFFLVRFTSLFFFLFFFLSFFLSFFPSFFFFLSFFFLSFFFLSFFLSFFFLSFFLSFFLFSFFFELLSTLIFYPLLFSLNIFLQSFFFFFACSSLLFAICLSFSFFFSFFLSSFFLFTFLLSVFSFFPGQIPKFSVIHLFFPYSLSQNSPTNSAQLFVLFQLPSISIPPPPFISDFFFSILFILPFDSPSGISLLSSFFFYLLFPSHISPNLVSSIFSSFRLSIHFSFCCIIFLYHSAILFFPPFLFFFDCGQAQIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CLE3</accession>
    <name>A0A812CLE3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SPHA_39330</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001818">
        <property type="protein sequence ID" value="CAE1275204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CLE3"/>
    <dbReference type="OrthoDB" id="6140671at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004031">
        <property type="entry name" value="PMP22/EMP/MP20/Claudin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21284">
        <property type="entry name" value="EG:80H7.2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21284:SF12">
        <property type="entry name" value="EG:80H7.2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13903">
        <property type="entry name" value="Claudin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAE1275204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="206" mass="23856" checksum="3952D2EF6005B622" modified="2021-09-29" version="1">MFLFGFVLSGVAVFCMVIAFSSPNWMESFEQADSKFVKLGLWEFCFNDYTFYKDYQGKRYRGCWYIFSYEYRPIWEWLSPPWFISVQVMISVTLLCQTLVVIFLLSLLVRCCPHQMESILLMISSIMMFLCGLLIAISLIVFGVMSEDRQWMPRPDQNFLSWSFGICVMSGFFSLFGAMCLLVASISASAERSTAPSMNMAMKTRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CMG1</accession>
    <name>A0A812CMG1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_38310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001733">
        <property type="protein sequence ID" value="CAE1273582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CMG1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039715">
        <property type="entry name" value="ZCCHC10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13491">
        <property type="entry name" value="ZCCHC10 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13491:SF0">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="309"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="348"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="403"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="449"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="485"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="515"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="541"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="570"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="622"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="658"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="690"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="727"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="791"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="816"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="856"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="879"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="931"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="972"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="997"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1036"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1096"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1167"/>
            <end position="1189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1273582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1235" mass="143003" checksum="732242A912709CEB" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CML4</accession>
    <name>A0A812CML4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SPHA_38781</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001779">
        <property type="protein sequence ID" value="CAE1274316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CML4"/>
    <dbReference type="OrthoDB" id="439127at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06799">
        <property type="entry name" value="PDZ_MPP3-MPP4-MPP7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11862">
        <property type="entry name" value="SH3_MPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.650">
        <property type="entry name" value="L27 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014775">
        <property type="entry name" value="L27_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004172">
        <property type="entry name" value="L27_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036892">
        <property type="entry name" value="L27_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050716">
        <property type="entry name" value="MAGUK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23122">
        <property type="entry name" value="MEMBRANE-ASSOCIATED GUANYLATE KINASE MAGUK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02828">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00569">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101288">
        <property type="entry name" value="L27 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51022">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032701031" evidence="3">
        <location>
            <begin position="21"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="L27" evidence="6">
        <location>
            <begin position="74"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="148"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="244"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAE1274316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="322" mass="36187" checksum="FAD43BD0CBE56AF7" modified="2021-09-29" version="1">MFPLSLSFVLFLSLLLFAFSGYDKILKGECMVDIKNHLLHFFSHSSPHLTPQEASDDQHQQVFNKVSSYASLQLGASSDSAVSTGVSVYNTLRKHKHKPHVDELREIMAKPHFQALLYTHDKVACRDYEPKLFSLPHEVNEAEEAVKIVRIIKNEEPLGATIQKNEKKQSLEIARILRGGAADRSGLVHVGDEICEVNGTNVQGCDPKEVVQLLAKFSGPVTLKLFPADNNKGIMRESKTYFRTPQIRLRALFDYDPFDDPIIPCPEAGLSFQKGDVLQIVSQEDPLWWQARKEGDSNLRAGLIPGKQLQERRTSSLLNGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CPZ1</accession>
    <name>A0A812CPZ1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_39571</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001848">
        <property type="protein sequence ID" value="CAE1275619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CPZ1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1275619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="324" mass="36788" checksum="AB993784B86259DC" modified="2021-09-29" version="1">MKQKPFIFQFFLLLFTDITATFPVSFIRLHCNAFLSLSLSLSLSLSHSLSLSLSRSLSLSPLFISLSLSLSLSLSLYCNTLSFSISLPLILCLSVCLSVSLSLSFFLSLSLSLSGSIHRYEQTKINRLQIDIMDCLTQIVTLSLSFSLSLSFSLSLILSLSLSLSLYFQIYALLILASYSHLSIYLSIYLSIYLSIYLSIISHLSICTCLAIYLYVHIYLSIYLSIYLSISILSYTHTEDREILSFLSLPVYSYLSVKPSVFFSYLSIYLSIYLSIYLSIYLSNFYLSIYLSIYLSIYLSILTNSYLSIYLSIYLSIYPSIHLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CRV3</accession>
    <name>A0A812CRV3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_38964</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001791">
        <property type="protein sequence ID" value="CAE1274593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CRV3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134:SF22">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134">
        <property type="entry name" value="OS08G0543275 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="307"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="393"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="423"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1274593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="455" mass="53522" checksum="2D55B69A7A6FF6C1" modified="2021-09-29" version="1">MNKSLTIGLKLIFPSLSIYLSIYLSIYLSIYLSITIHTLSIYLSMGIYLSIYLSIYLSIYLSIYLCPFLSIYISRFISIYLAIYVHFYLSISAGSFHSIYLSLYVCPFLSIYISRFISIYLSIYLSIYLSIYLSIYLCLSISIYLYQPVHFYLSIYLSIYLSIYLSIYVCPFLSIYISRFISFFLSIYLSIYLSMSVHFYLSISAGSFLSFYLSIYLSIYLSIYLSIYLSISIYLYQPVHFFLSIYLSIYLSIYLSIYLSMPVHFYLSISACSFLSFFLSFFLSFFLSKSIYLSDSVNNYIFYPVDIYLSIYLSIYLVLLIPISLFYPVDIYLSIYLMLLISIYLSIYLSIYLFYAVDIYLSIYLILLIPISLFYAVDIYLSIYLSIYLSIYLSIYLILLTSIYLSIYLSIYLSIYLSDFVDIYLSIYLILLTSIYLSDFVDIYLSIYLSIYLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CT53</accession>
    <name>A0A812CT53_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_40166</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001894">
        <property type="protein sequence ID" value="CAE1276666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CT53"/>
    <dbReference type="OrthoDB" id="44820at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1276666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="240" mass="26736" checksum="D90DF1D260C796E8" modified="2021-09-29" version="1">MPVQVRTLNLKLIKWAQLRVTSYVTHLDTKKFNETVRGHCTALSLGTIDQFGQIAPTSQPRAELLNCNPIPALTQSKDNFLDPCCSHGSTSSLDVTTCSFHLSGDKPGIGPTTVVEVLVPACTKTQPPCSSLSWSNSQPKSQLVSYSCEKHKSLELTCNPSPSPGSSKPPAQRNGPSEEQLHQVKERLIEVVPNFFKRTHDYRLYNPNMVFINNFWGKETVHRGLSAYMMELSNNYLFVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CU63</accession>
    <name>A0A812CU63_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_44909</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002304">
        <property type="protein sequence ID" value="CAE1284724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CU63"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1284724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="203" mass="24315" checksum="F095398BBF3706A8" modified="2021-09-29" version="1">MSFLLHTVYRTNPIFILSIYQSIFRPSFSIYFHSIYYPFHLLFSIYPSIASNFFPYIVSFGNLIFRPYRLILFCNWYPSIYLSIYLFSDHLNLNLFSDRLFFFLFSKPSQALSIYFQTISRLSILILFLSIYLSILFQTFYFNPFFSDRLIESIYFLSVSRPSLFSILFLIQLSIVSIDILSIFQTIFPQSIFQILPLSFYPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CUK4</accession>
    <name>A0A812CUK4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="24">PKD2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">SPHA_42247</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the polycystin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002057">
        <property type="protein sequence ID" value="CAE1280320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CUK4"/>
    <dbReference type="OrthoDB" id="444119at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050982">
        <property type="term" value="P:detection of mechanical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000055">
        <property type="entry name" value="Polycystic kidney disease 2-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000020">
        <property type="entry name" value="polycystin-2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013122">
        <property type="entry name" value="PKD1_2_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003915">
        <property type="entry name" value="PKD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051223">
        <property type="entry name" value="Polycystin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046791">
        <property type="entry name" value="Polycystin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10877:SF183">
        <property type="entry name" value="AT14535P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10877">
        <property type="entry name" value="POLYCYSTIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08016">
        <property type="entry name" value="PKD_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20519">
        <property type="entry name" value="Polycystin_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01433">
        <property type="entry name" value="POLYCYSTIN2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 19" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 19" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="19" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16" id="KW-0966">Cell projection</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="18" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="17 19" id="KW-0407">Ion channel</keyword>
    <keyword evidence="12 19" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 22" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="96"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="343"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="381"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="423"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="470"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="532"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="23">
        <location>
            <begin position="593"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="673"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="794"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="682"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="21">
        <location>
            <begin position="693"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="640"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="642"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="644"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="651"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="200"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR603915-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR603915-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="CAE1280320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="864" mass="98889" checksum="9A05EC7B4594F68F" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CWC8</accession>
    <name>A0A812CWC8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_44433</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002269">
        <property type="protein sequence ID" value="CAE1284007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CWC8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1284007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="247" mass="28395" checksum="2FFD6FA1B0E0A34F" modified="2021-09-29" version="1">MFLKSTSSVFFFFFFFFFFFFFFFHSSVSFSFFSSFYSSCPFSSSSSSSSSSSSSFSSLTHLSTSFMPSPLSLYKRVKRFTHTHPDDTLLSTPFRVMKPIKSVIAHGPQLEKLFSLSLVLSLTRSLDIYLSSIYLSIYLSIYLSIYLSIYLSLSLSIYIYIYIYIYIYISLSLTLVSIDTQKHLPLFRFFSFSPPLSVCLSVSLCLSLSFTYAYTSNVNRLICEKAIITNLSIYLSIYLSIYLSIPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CY46</accession>
    <name>A0A812CY46_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_42592</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002090">
        <property type="protein sequence ID" value="CAE1280857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CY46"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1280857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="244" mass="29642" checksum="BB1F4CD06BEA52AC" modified="2021-09-29" version="1">MPLFIFLSIIFICCPSIYLSIYLSIYLSIYLHIYMYYKNLLKHLLYLSIYLSIYLSIYIHIYLSVCLFHSYLSIYLSIYLSIYLSIYLSTYLYYKNLLKHLLYLSIYLSIYLSIYLSIYLSIFIFIFICLSLHLFSKYISVHFLSIYLSIYLSIYIFIYMYLFYLFIYLFMGIIYLSLLLFVSLSIYFQIYISVQVISIYLKYTEYHLLFHLNLYLLWIPSFNSHSFFTSSSSNYLYISFSLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D7E6</accession>
    <name>A0A812D7E6_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SPHA_47447</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002569">
        <property type="protein sequence ID" value="CAE1289046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D7E6"/>
    <dbReference type="OrthoDB" id="6093997at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1139"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1172"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1203"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1233"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="204"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="373"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="499"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="807"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1053"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="206"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="373"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="391"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="417"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="446"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="507"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="532"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="811"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="830"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="862"/>
            <end position="874"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAE1289046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1256" mass="140372" checksum="A22785065EC1A5C3" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D8N1</accession>
    <name>A0A812D8N1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_47229</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002551">
        <property type="protein sequence ID" value="CAE1288640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D8N1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="290"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="313"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1288640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="403" mass="46923" checksum="D6882389A77D891A" modified="2021-09-29" version="1">MLSFSLFHSLSLSLFLFSLSQTLSHYLYPTLLFIRYFLSLFLPLYRTLYFTLLSLSFVHFLKLFLTISTPLSCLSNTFFLSFFLFIELFISFSGSLFSLFRSLSQNFSHYLPGLLFIRYFLSLFLPLYRTLYFKLSLLFFCSLSQTLFSLSLPQSPVYQIDSFSLSSSLSNSLFPKNNLSLLSLSLFTHFLKLFLTISTPLSCLSDTFFLSFFLFVKPFLLLSFSISHPLSQSLFLTLLFINYFLSVFLLFLSNSFLHTLSVSLTLFLKFFLHIFLFLKYFEFFSSLPNYILFFLSVSFFFLFPSPFHSFSSISFHLTFFYILLFFLRASLKIVQDAMRRVTSFVTSYTAYMSSHLCKKATFSCVVSGLIDLIRFSLSLSLSLSLSLSLSHSIFPYFFLSFSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DAR5</accession>
    <name>A0A812DAR5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_48945</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002768">
        <property type="protein sequence ID" value="CAE1291829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DAR5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051897">
        <property type="entry name" value="PG-associated_BURP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31458:SF16">
        <property type="entry name" value="BURP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31458">
        <property type="entry name" value="POLYGALACTURONASE 1 BETA-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1291829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="226" mass="26042" checksum="5359D1167CB263EE" modified="2021-09-29" version="1">MSLSIFRPTSSRTAMSLSIFRPTSSRTAMSLSTDHVPFRSYGHHSVDRSCPFRSYGHHSVDRSCPFRSYGHHSVDRSCPFRSYGHHSVDRSCPFRSYGHHSVDRSCPFRSYGHHSVDRSCPFRSYGHHSVDRSCPFRSYGHHSVDRSCPFRSYGHHSVDRSCPFRSYGHHSVDRSCPFRSYGHHSVDRSCPFRSYGHHSVDRSCPVLWPSFRRPIMSLFGLMAIIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DBY6</accession>
    <name>A0A812DBY6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNAH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SPHA_53462</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Farmed</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the dynein heavy chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003402">
        <property type="protein sequence ID" value="CAE1299792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DBY6"/>
    <dbReference type="OrthoDB" id="5593012at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000063">
        <property type="entry name" value="dynein heavy chain 6, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001328">
        <property type="entry name" value="Dynein heavy chain 6, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041466">
        <property type="entry name" value="Dynein_AAA5_ext"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703">
        <property type="entry name" value="DYNEIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703:SF1">
        <property type="entry name" value="DYNEINS HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17852">
        <property type="entry name" value="Dynein_AAA_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein heavy chain hydrolytic ATP-binding dynein motor region" evidence="3">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase dynein-related AAA" evidence="2">
        <location>
            <begin position="188"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain AAA 5 extension" evidence="4">
        <location>
            <begin position="368"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAE1299792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="411" mass="46122" checksum="A570C27DD7441375" modified="2021-09-29" version="1">MNALRLNLGGAPEGPAGTGKTETCKDLAKAVAKQCVVFNCSDGLDYKAMGKFLKGLAQSGAWACFDEFNRIELEVLSVIAQQVQTIQRAITEQATMFVFEGTKISLDPTCSIFITMNPGYAGRAELPDNLKVLFRTVAMMVPDYAMIGEISLYSMGFVDARSLSIKIVATYRLCSEQIYDMVLVRHGLMIVGDPVAGKTTAYKLLAEALGDLHRQNLMDEFPVEYRIINPKAITMGQLYGRFDPISHEWADGVLANTFREHASSVNVTRKWTVFDGPVDAVWIENMNTVLDDNKKLCLMSGEIIQMSKWQNLMFEVHNLEQASPATISRCGMIYMDPAQLGWNALVWSWMQQNLHGFTDAEKETVKFLFDWLLPPSLNFVTLQCHQIVPCQQMHMVLSMIKLYGVLLKEIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DC51</accession>
    <name>A0A812DC51_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_49145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002783">
        <property type="protein sequence ID" value="CAE1292206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DC51"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="343"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="436"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="466"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="499"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="526"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="558"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="596"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="628"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="654"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="684"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1292206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="745" mass="88848" checksum="8D6DEBD49D1CDAFA" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DD11</accession>
    <name>A0A812DD11_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_51443</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003109">
        <property type="protein sequence ID" value="CAE1296405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DD11"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1296405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="205" mass="23017" checksum="8EB85D3C36BCE1C6" modified="2021-09-29" version="1">MNRLSQIPQFYGTKRKIKILLFFHLSFPFLFLSLYLLVSLSLSLSLSLSLSLSLFLSFSLPTLLSPSRLSSSPLFPITGLFPPPSTLSVSLSVSLSLSLSLTLSLTHTLFSVYIISLPKSSLFSSFSSLVTQSLFPLFLLFASYPPFSLNFLFPCLALLLSPLLSCPYSPSFLPSTFFPRPLFLNHLFLFFSFFLSFFLSFFLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DIC6</accession>
    <name>A0A812DIC6_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">3',5'-cyclic-AMP phosphodiesterase</fullName>
            <ecNumber evidence="1">3.1.4.53</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SPHA_57270</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.53" evidence="1"/>
    <dbReference type="EMBL" id="CAHIKZ030003856">
        <property type="protein sequence ID" value="CAE1304724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DIC6"/>
    <dbReference type="OrthoDB" id="189220at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004115">
        <property type="term" value="F:3',5'-cyclic-AMP phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040844">
        <property type="entry name" value="PDE4_UCR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11347">
        <property type="entry name" value="CYCLIC NUCLEOTIDE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18100">
        <property type="entry name" value="PDE4_UCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0114">cAMP</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphodiesterase 4 upstream conserved regions (UCR)" evidence="6">
        <location>
            <begin position="88"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="37"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="112"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="140"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF18100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAE1304724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="239" mass="27086" checksum="714F3765F66D5A30" modified="2021-09-29" version="1">MSGHRSRSLFRRRHPSGSSDLDTLTVPVITVNMQYLSPNHNTSSSSSSSSSVSQGKTRNWLSKLRREPRNKSKNSLSSSSRHSEDLIVTPFAQILASLRSVRNNYLNLTNVNLPKERTRRGSSTGPHGSQREHHQPPPQTSQNSQSGSTNKDEAYYKMALETLEELDWCLDQLETIQTHRSVSDMASSKFKRMLNRELSHFAESSKSGNQIAEFICSTYLGKSVIFYSFFLSFLILYFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DIN4</accession>
    <name>A0A812DIN4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_54339</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003535">
        <property type="protein sequence ID" value="CAE1301341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DIN4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1301341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="236" mass="26858" checksum="80C7918160609D4C" modified="2021-09-29" version="1">MKYTVGFFLKSQYDFYNNRSIINPTFRARFPWTSYSFYLDLGLFVSVTPSCSIDLFHFTFAFLSWSHHLYLCLSILVSPSVSLHLCHSILPYLSHSIFASPSMSLSWSLHLSPYLYRSILVSPSASLYFGLLIFASLSPSLSCFIFTFLDISMLVSLSCSILLCSSVLLSSYLSFFILISLPFVHSLSLSLLISPFLLHHLLLFILIFVPLSSSPHLFSLSVFAISFFSIYIWLSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DK04</accession>
    <name>A0A812DK04_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_55057</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003633">
        <property type="protein sequence ID" value="CAE1302542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DK04"/>
    <dbReference type="OrthoDB" id="10684523at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1302542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="243" mass="26723" checksum="4FC54DA8883D33D9" modified="2021-09-29" version="1">MASLAILFCHNCYPLPPPLAFLFGLICNLLPLHLLPSSASPAIIFRHICYPLTPQLLSLSATTCIPLRPHLLSSSATRDIPFRHICYPLQPPLAFFFGLTCNPLTLHLISSSASLATLFRLTCYPLPPHLLSSFTTIAIPFRHPLHSSSASPAILFRYICYPLLPPLAFLFGLTCNPPPPHLLSSSATPAILFRLTCYSLRPQLLSPSATPCLPLRPYLQSSYASSAILFRFTCYPLPQPFPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DKZ4</accession>
    <name>A0A812DKZ4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BGN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SPHA_54147</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003496">
        <property type="protein sequence ID" value="CAE1301011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DKZ4"/>
    <dbReference type="OrthoDB" id="10008953at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000372">
        <property type="entry name" value="LRRNT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050333">
        <property type="entry name" value="SLRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712">
        <property type="entry name" value="AGAP008170-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712:SF22">
        <property type="entry name" value="INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN COMPLEX ACID LABILE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01462">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00013">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="LRRNT" evidence="5">
        <location>
            <begin position="221"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAE1301011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="407" mass="43819" checksum="E6E371FC137A238B" modified="2021-09-29" version="1">MVCGRRRLKARCRDEQGRMSIWSPALHHSCCEPSLFNSLSIYATLPIPSLSLSLFLSPLGPPSPNTPALIVSLSQIFFLYSRSHYPSLFSLQLVLAPSLSRSVTCLWLRKALPPTPFIGIRGEGRCECPMRFLISFPSLYGTTYLSSGIYPPTTITHPALSAPLAVPPTTIASFTLTATLRLYRAPPILGGLSNSGSNLDIFTNRTRQIKVPSTTRVVHDQCPTVCSCLGSMVDCSEKGLTRVPPDLPSWLVMLDLQANGILELRKDDFKGLDNLEKLDVSGNKITIIDEAVFSHLPNLKEFLSPSLTLSLSLSLSLSLTLSLSLSLSLSLTLSLSLSLSLSLSLSLSRLSLSPLSLSLTLSLSLTLSLSLSLSLSLSPLSLSLSDSLSLSLSLSLSSLTLSLSLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DNX9</accession>
    <name>A0A812DNX9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_59745</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004140">
        <property type="protein sequence ID" value="CAE1307716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DNX9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1307716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="157" mass="17495" checksum="F725D3FE98C295A6" modified="2021-09-29" version="1">MPQLSITPPYLSYPLLHHASAIHYSTMPQLSITPPCLSYPLIHHASAIHYSTMPQVFITPPCLRYPLLHHASAIHYSTMAQLSITPPCLSYPLLHHASAIHYSTMTQLSINPPCLSYPHPTMPQLSITPPCLRVSTIHYSTMDHTMPPPCPIHLLPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DQ45</accession>
    <name>A0A812DQ45_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_59260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004104">
        <property type="protein sequence ID" value="CAE1307152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DQ45"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="309"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="343"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1307152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="386" mass="45394" checksum="5D07FA1B6474EFF3" modified="2021-09-29" version="1">MHNQFNHLSIYLSIYLSIYLSIYLSIYLSIYLNPYLSIYLSIYLSIYLSIYVSFAGDIIRADGAKAGKFVDDFYRLPVDVDADVQCCWIFVFLSLTCIPKPDKYICLFLFLLFPFVSGFSSVRLFFLSLFLSLSLSLFFLSFFIFVSLPLSHFISFLSFFLSFFLSFFLSFFLFLFSFFLFLSFFLSFFSFFFSFFSSFFLSVSFCLLVSFCLPLIVPFYLSFFLSFFLSTPITILFFLSFFLSFFLSFSFFLSFFLSSPITILFFLSFLSFFFFLSSPITILFFLSFFLSFLTFFLSLSLSFCLSVSSFFLCMFVSYFLFSFLSVSFCLLLSFCLPLIKRNIYLSVHLSLFISIYLSIYLSIYLSIYLHEISIYLSIYLSIYLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DQF5</accession>
    <name>A0A812DQF5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_60263</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004186">
        <property type="protein sequence ID" value="CAE1308390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DQF5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="45"/>
            <end position="65"/>
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            <begin position="77"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="107"/>
            <end position="126"/>
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            <begin position="138"/>
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            <begin position="176"/>
            <end position="200"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="221"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="985"/>
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            <begin position="1106"/>
            <end position="1126"/>
        </location>
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        <location>
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            <end position="1161"/>
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        <location>
            <begin position="1167"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1192"/>
            <end position="1214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1308390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1230" mass="138877" checksum="0822A76ADF211AB7" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DQY6</accession>
    <name>A0A812DQY6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_61042</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004282">
        <property type="protein sequence ID" value="CAE1309295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DQY6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="EMBL" id="CAE1309295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="700" mass="80796" checksum="64A07DF13A30CBD0" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DVK6</accession>
    <name>A0A812DVK6_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase A2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_62277</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004441">
        <property type="protein sequence ID" value="CAE1310754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="6276451at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="RP_Saci_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon opus-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_A2_cat"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="RP_Saci-like"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ASP_PROT_RETROV"/>
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    </dbReference>
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            <end position="197"/>
        </location>
    </feature>
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        </source>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1310754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DXN6</accession>
    <name>A0A812DXN6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_61899</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Lophotrochozoa</taxon>
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            <taxon>Decapodiformes</taxon>
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            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
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        </lineage>
    </organism>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004391">
        <property type="protein sequence ID" value="CAE1310195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DXN6"/>
    <dbReference type="Proteomes" id="UP000597762">
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    </dbReference>
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        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
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        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        </location>
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            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="393"/>
            <end position="414"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1310195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="418" mass="49870" checksum="F1F41E5122A623B9" modified="2021-09-29" version="1">MYIYICYFQLISIYLSICLSVCLSVYLSIYLSIYLSIYLSQSFHIYHNQFISICQLFSINIYLSIHLSNYLSIYLSQSFRIYLNQFISICLLFSINIYLSIYLSIYLSIYLSIYLSPFISILINLYLYVSYFQLISIYLSIYLSIYLSIYLSIYISQSFHIYLNQFISICQLFSINIYLSIYLSIYLSIYLSQSFHIYLNQFISICLLFFNIYLSIFYLSIYLSIYLSISSFHIYLNQFISICLLFSINIYLSIYLNLFIIYLSIYLSIYLSIYLNLFISILINLYLYICYFQLISIYLSIYLSIYLSIYLSQSVHIYLNQFISICLLFSINIYLSIYLSIYLTLFISILINLYLCLLFSINIYLSIYLSIYLSPFISILINLYLYVSYFQLISIYLSIYLSIYLSIYLSLFIISIPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DYM0</accession>
    <name>A0A812DYM0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_61524</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004362">
        <property type="protein sequence ID" value="CAE1309880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DYM0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1309880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="186" mass="22744" checksum="F43A2869B5436AE4" modified="2021-09-29" version="1">MFLISQFYFFFLFNSLFSYLHLINDTLFLSFFSFFTSFSSNDQNSFLLFLSFFLSFFLSFFLSFFLSFFTFYLFPIIFFLSFFLSFFLSFFLSSFFNLLPIIFFLSFFTFYFFPIIFFLSFFLSFFLSFFLSFFQIQFLIFSTLFFICLFLSLSLSLSLSLSLSHTHTLVPYFLHFLLSNHFRFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DYR2</accession>
    <name>A0A812DYR2_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Spermatogenesis-associated protein 1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SPHA_62350</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004457">
        <property type="protein sequence ID" value="CAE1310862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DYR2"/>
    <dbReference type="OrthoDB" id="9901850at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039062">
        <property type="entry name" value="SPAT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031478">
        <property type="entry name" value="SPATA1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14421">
        <property type="entry name" value="SPERMATOGENESIS-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14421:SF3">
        <property type="entry name" value="SPERMATOGENESIS-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15743">
        <property type="entry name" value="SPATA1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spermatogenesis-associated protein 1 C-terminal" evidence="3">
        <location>
            <begin position="421"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="93"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="180"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="281"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="393"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="588"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="544"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="93"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="109"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="284"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="305"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="401"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="588"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAE1310862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="621" mass="72083" checksum="3DED77E3A6C0C11F" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DZN7</accession>
    <name>A0A812DZN7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_62048</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004400">
        <property type="protein sequence ID" value="CAE1310456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DZN7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1310456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="219" mass="25837" checksum="A120FD94AF64CDD2" modified="2021-09-29" version="1">MLNRMKENIRFAFMASYFELKRPEEHVFFSRLNDASGLPHWRRHFRQASHIQLSEHEADREVNIIYLSIYLSICHTLHMHMSRSEHLSIYDTIHIHLSRSVHLSIYLSIYLSIYLSIYLLSLHMHMSRSEHLSIYDTIHIHLSRSVHLSILSIYLSIYLSITLFTSIYHILHITLSRSIGVGRSFRYSLSLSLSLSLSLSLASYIYLSIYLSIYLSIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E258</accession>
    <name>A0A812E258_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_64650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004651">
        <property type="protein sequence ID" value="CAE1313538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E258"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1313538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="213" mass="25140" checksum="714CCEE2490E8CC2" modified="2021-09-29" version="1">MDPANSLTYLKTTLSSEMFLNRYFYSVSLFLSSRPNLLFLSFTFSSLKFLRIYSSILSLMFYRLSLSPSLHLIFPCIHSFYIFLIHLPSIFIIFLTTTFFYFPPLFSTLLLLSPLSLFPNSFWFFSFLSHFISPVCNSFLSFFLLFLSQLFSFISTFSFTLVYMQLATSIFFISLPFSFFQFDYSFFLSLFLSSFLLRRQISSNEIEAYLFIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E2Q0</accession>
    <name>A0A812E2Q0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_67180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004867">
        <property type="protein sequence ID" value="CAE1316477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E2Q0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1316477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="228" mass="27511" checksum="39BA9EC5E225B846" modified="2021-09-29" version="1">MSLLSPLSLFLSLSLSLSFNYASFFPTFPHFRLYTFTTYLILSPSVLLISFLSFFLSFLSFFFLSFFLSFFLSFYPLQYCSFLTFFLSFFLSFFLSFFFFLFQFFLSFFFFTHFLLPSPSMLHHSFFLSFFLSFFLSFFLFFSTYLILSPSVLLISYFLSFFLSFFLSFFLAFSIFLSFFFFFTHFLLPSPSMLHHSSFFLSFFLSFFLSFFMRPARLVSSNYYIRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E2R8</accession>
    <name>A0A812E2R8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_67206</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004867">
        <property type="protein sequence ID" value="CAE1316501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E2R8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1316501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="424" mass="46549" checksum="A1DC796E44FF1155" modified="2021-09-29" version="1">MGPSKRAGVGMVSLWIASIPQRPIRRPPTTVRMWGEASLFPRTLLALRLSEPLDQINLLVTILLVSARRSRPQRSCSADTTAGHARALCDPTTAPASNFDPGDAPSAPLSPSTKPFLLAMAWVFIEPALSRANFSKTGVRRLAQSLLPSPVVVFGVGKGYLVLFFPLIPFLNFGRASGILRFFGDGGARTTSSGASLRISICCSLPLSRPLRSLLNQWKQKRTRNNSGEFQQQIEEKENRKVPYLSFRANRTVRNPDQMSLGSIFTFSCGYVWVYPGHGTSYDAWPQAAQLPRWDPVSSADRVTDHFERTVLPHVVLKDLSLEQGAKSEVFYFQTTGHMGTGLVLSVSVQLPACPFGLRLRACVCSVSNSPRLLILWGPVKGLGWAWCLSGSPAYPNDQSEGFLQPSECGEASFFPRTLLALRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E330</accession>
    <name>A0A812E330_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_65184</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004693">
        <property type="protein sequence ID" value="CAE1314149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="291"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="319"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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    <feature type="transmembrane region" description="Helical" evidence="1">
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    </feature>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="826"/>
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        <location>
            <begin position="866"/>
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        </location>
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        <location>
            <begin position="898"/>
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    </feature>
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        <location>
            <begin position="927"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="978"/>
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        <location>
            <begin position="1003"/>
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        <location>
            <begin position="1038"/>
            <end position="1059"/>
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    </feature>
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        <location>
            <begin position="1065"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1093"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1116"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1145"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1172"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1205"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1232"/>
            <end position="1257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1314149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1326" mass="162934" checksum="2378810066F58D52" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E3X2</accession>
    <name>A0A812E3X2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_65828</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004736">
        <property type="protein sequence ID" value="CAE1314801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E3X2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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            <end position="89"/>
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        <location>
            <begin position="101"/>
            <end position="123"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1314801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="178" mass="20593" checksum="C8B743D8D501E677" modified="2021-09-29" version="1">MFLFLPYLYPRKKKNNLSEFNKILRRLLCHTSPLLFLSFTLSLGIPPYSLCLSIYLSIYLSIYPRVPSLLYCLIYNLYIVLLAFLPFCLPSFLPSCLTSFFLSFLPSFLPTFLSFQASLFAPASYTQSLSFQTLSFLPFNSFLFPPAHFLPFFLLSFQTFSFINHYSLPTLILSAFLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E485</accession>
    <name>A0A812E485_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_65859</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
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            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004740">
        <property type="protein sequence ID" value="CAE1314924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E485"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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            <begin position="21"/>
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    </feature>
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        <location>
            <begin position="283"/>
            <end position="301"/>
        </location>
    </feature>
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        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1314924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="410" mass="46902" checksum="DAAA5BCD94CD273B" modified="2021-09-29" version="1">MFIYLSIYLSIYLSIYNRHSFVSLLSLSLCLVNVISLSQSMFIYLSIYLSIYLSIFIYLSLSLCRDIHLSLSLSLSICLVNRHSFVSLLSLSLPSVYSVIYLSIYLSLSIYLSIYNRHSFSVHVYLSIYLSIYLSIYLSTFICLSPLSLSLPNVMYPQSVHVYLSIYLSIYLSIYLSITDIHLSLSLSLSLCRVNVMYPQSVHVYLSIYLSIYLSIYLSIYRHSFVSPLSLSSMNVMYPQSVSMFIYLYLSIYLSIYLSITDIHLSLSLSLSLPRERDISQSVHVYLSIYLSIYLSIYLSITDIHFSLSLSLSLCLVNVIYLSLYMFIYLSIYLSIYLSIYLSISISLSSFVSLPLSLSLPIISIYLSIYLSIYLSIYRHSFVSLPLSLSLPSERNVSSVSPCLSIYLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E4W3</accession>
    <name>A0A812E4W3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GPR158</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_67816</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004911">
        <property type="protein sequence ID" value="CAE1317225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E4W3"/>
    <dbReference type="OrthoDB" id="2129233at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="178"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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        <location>
            <begin position="384"/>
            <end position="410"/>
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        <location>
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            <end position="442"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="454"/>
            <end position="477"/>
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        <location>
            <begin position="483"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="534"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1317225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="552" mass="63610" checksum="8F14BEEEF6957F9D" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E7V7</accession>
    <name>A0A812E7V7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_67253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004870">
        <property type="protein sequence ID" value="CAE1316591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E7V7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
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        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="60"/>
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            <end position="223"/>
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    </feature>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1316591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="433" mass="50725" checksum="2C7852A302FC10EB" modified="2021-09-29" version="1">MHTSIHVCPSSIFVCSHLSIYLSIYLSIYLSKSYLIYLNLPISMCSYLSIYLSIYLSIYLSIYLSIYLRLYIIYLSIYLSIYLRLYLSIHSFIQVYSYLSIDRSIYLGLYLSIHSFIHVYSYLSIYLSIYLSIYLSIYLSIEVYSYLSIQICSYLSIYLSIYLSIYLSIYLSPSVHYLSIYLSIYLSSFISIYSFIHPVYSYLSIYLSIYLSIYLSIYLRLYLSIPSFIQVYSYLSIDRSIYLGLYLSIHSFIHVYSYLSIYLSIYLSIYRSLFVSIYPNLFVSIYLSIDLSIYLSFYLSIYLSIYLRLYIIYLSIYLSIYRSLFVSIYPNLFVSIYLSIYLSIYLSIYLSIYLSPSVHYLSIYLSIYLSIYLSQSIHMTSELLLPTNATGSLDKSVDGVHITLDAYTFGFPLSFSPFSSSPSSSPSKRKKYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E825</accession>
    <name>A0A812E825_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_69591</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
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            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005093">
        <property type="protein sequence ID" value="CAE1319151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E825"/>
    <dbReference type="Proteomes" id="UP000597762">
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        </location>
    </feature>
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    </feature>
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            <end position="287"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAE1319151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="288" mass="34782" checksum="38E9D71BB2B94A1C" modified="2021-09-29" version="1">MVFLSSFFFFSFFSFFHFFSFFFFLSSIIFLSSSLLSFINNLFLSSSLPSFINKLFSFHLFFLIFFFSFITFSFFFSFSLNFFSFFFSSFFINNLFFLLLFFLSSIKLFFLFFLLKSIIFLSSSLLSFINNLSFLLSYSFSFINKFSFFFSSFSFFFFLSFFLYFFFSSSFSFLSSSLLFFSSIIFSFFFSVFFHQFSFLSSSLPSFINNLSFLLLLFLLSSISFSIFLSSSFFHQSCFIFFLLSFFFFFSSISFFFFFFSSFFHLLFFLFLLFFFSIVFFIFFISFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E8D0</accession>
    <name>A0A812E8D0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PGRP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_66625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
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        <lineage>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004810">
        <property type="protein sequence ID" value="CAE1315744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E8D0"/>
    <dbReference type="OrthoDB" id="10001926at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.80.10">
        <property type="entry name" value="Peptidoglycan recognition protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Amidase/PGRP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015510">
        <property type="entry name" value="PGRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11022">
        <property type="entry name" value="PEPTIDOGLYCAN RECOGNITION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11022:SF41">
        <property type="entry name" value="PEPTIDOGLYCAN-RECOGNITION PROTEIN LC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55846">
        <property type="entry name" value="N-acetylmuramoyl-L-alanine amidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        </location>
    </feature>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1315744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="388" mass="45639" checksum="41E814F8D18A8D1F" modified="2021-09-29" version="1">MSYGKELPIVTTDFFQITSRSLSVTVVFKSRQCTWKQQLSLILSISFFLSFFPFFLSFPFFLSFFLSFFLSFFALLSFSFFLPFFLSFLLLSSCSLSYLFRGCAEEFDGVRSFPSFSKSPPFLLLIIRLFLSLFFLISFSFLSLFHFTLYSLSFPFHSLFSLFSISLSILSLFHFTLYSLSFPFHSLPLFSLFSFLSLFLSHLSLTHKDSFILYLHISLQRKKWKMTLLSFFLFLLVGVVVYCKNWDHYLVRRNCHIEPGMYRVYLERLRWSYVLLCLVLLIILIIVVFSVAIEQTIMQQPQTARIVAGPMFRYNCSNVFLVSRSEWLAAAPKETVTMRTPVQLVFIHHTALSHCFHFQNCSKEVKQIQDLHMIKKGEFRFEGILFLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EBJ8</accession>
    <name>A0A812EBJ8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_70002</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005119">
        <property type="protein sequence ID" value="CAE1319714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EBJ8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039715">
        <property type="entry name" value="ZCCHC10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13491">
        <property type="entry name" value="ZCCHC10 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13491:SF0">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="253"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="288"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="328"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="389"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="422"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="450"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="475"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="500"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="528"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="560"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="588"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="623"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="669"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="712"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="741"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="765"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="819"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="846"/>
            <end position="865"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="872"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="897"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="930"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="963"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1096"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1113"/>
            <end position="1129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1319714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1140" mass="132932" checksum="FE1DED94759ACF19" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EBX1</accession>
    <name>A0A812EBX1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_70819</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005183">
        <property type="protein sequence ID" value="CAE1320601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EBX1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1320601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="175" mass="19854" checksum="A1C6C0B0F5813FC0" modified="2021-09-29" version="1">MEVQSEGAEAEYTVHLSNHNSSKQRPITVVQFKEQRPNIQCIVQIKQFMEVQRIVVVKFSSEATEAEYTVHLSNHNSSWKFSQKGAGADIQQCIFNITVHGSSVRRSRRPNIQCICQISSWNSVRRSRGRIYGALSNHNSSWKFSQKGAGAEYTVHLSNHNSSWKFSQKGAEAQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EDX3</accession>
    <name>A0A812EDX3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_73511</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005380">
        <property type="protein sequence ID" value="CAE1323558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EDX3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1323558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="260" mass="30536" checksum="C617FDA0C791353F" modified="2021-09-29" version="1">MVLHTLIDSLQRLSFPFFFFFFFFFFFFFFFFFFFFFLSLSLFRSDLIFYFFSFYVAILYAFSLLSSTASFPLPLLVLHQNPFFPSLSLSLSLSLSLSDYLSINLSIYLFHLTSLSPTFISLSLIHTHKHTFSVSLCVCIYIYIYIYIGIILFQIFSYLFPFLLSVTLFLPYLFFFSSYLPFIQISLSLSLSLSLSVPLSVCLSVSLSLSLSLSLSLFVLFFFNLSLSLIYLSIYLSIYLSIYLSIYLSIYRYIYICLFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EDX9</accession>
    <name>A0A812EDX9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_69549</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005089">
        <property type="protein sequence ID" value="CAE1319117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EDX9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1319117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="270" mass="32096" checksum="534290145975A4F4" modified="2021-09-29" version="1">MYFCLFSLFTPIYLSINSIRIYLNYLSIYLVYSHLSLSFHLFSLFTSISHLSIYLSIYLSIYLFNSNLFSLFTSIYLSRLFSTIIFFYLFSMFTSIYLCLFKSLHIFLSIYSIHIYLSIYLSIYLSIYLSIYLSPTLHISIYLSIYLSIYLSIYLSILAYRVSIYLSIYLSIYLSIYLRRPSGFAGDSEVRSVNWTFLSIYLSIYLSIYLSISNFKTIFAGNSKFYLSIYLSIYLSIYLSIYLFELDYILIYYIYLSIYLSIYLSIYLSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EDZ9</accession>
    <name>A0A812EDZ9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_71346</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005219">
        <property type="protein sequence ID" value="CAE1321183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EDZ9"/>
    <dbReference type="OrthoDB" id="6153212at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134:SF22">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="OS08G0543275 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="33"/>
        </location>
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        <location>
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        <location>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="274"/>
            <end position="303"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="342"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="377"/>
            <end position="402"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="408"/>
            <end position="428"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="440"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="527"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="559"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="587"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1321183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="616" mass="69985" checksum="85C2786E3D172597" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EF76</accession>
    <name>A0A812EF76_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_71961</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005280">
        <property type="protein sequence ID" value="CAE1321955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EF76"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
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            <end position="22"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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    <feature type="transmembrane region" description="Helical" evidence="1">
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAE1321955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="235" mass="28279" checksum="9ED5878BBBB14FB3" modified="2021-09-29" version="1">MCTYLSIYLSIYLSIYLSIYLYNSIYLSIYLSIYLSIYLSIYLSISLSLSLSLSLSLSLYIYIYIYIYIYICVCVYTAIYQFISPPVNSLSIYLSIYLSIYLSIYIYIYIYIYITIYQFISPAFIYLYLSIYLSIYLSIYLSIYLSIYIYIYIYIYIYNYLSIYLSARQFFIYLSIYLSIYLSIYLSISLSLSLSLSLSLYIYIYIYIYIYWHVSIYFSLVYLLNGPFLSTFELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EHA4</accession>
    <name>A0A812EHA4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_73606</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005382">
        <property type="protein sequence ID" value="CAE1323795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EHA4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <end position="24"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="130"/>
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="555"/>
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        </source>
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        <source>
            <dbReference type="EMBL" id="CAE1323795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="557" mass="65352" checksum="4BC815455B7D380A" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EKA1</accession>
    <name>A0A812EKA1_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SPHA_76090</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
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        <lineage>
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            <taxon>Acanthosepion</taxon>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005480">
        <property type="protein sequence ID" value="CAE1326525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EKA1"/>
    <dbReference type="OrthoDB" id="5961712at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="8">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="7">
        <location>
            <begin position="536"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="287"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="369"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="455"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="294"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="461"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="487"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAE1326525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="741" mass="83196" checksum="4DC6683D536A07DE" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EL89</accession>
    <name>A0A812EL89_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SPHA_74541</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the X(+)/potassium ATPases subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005433">
        <property type="protein sequence ID" value="CAE1324844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EL89"/>
    <dbReference type="OrthoDB" id="5912413at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005890">
        <property type="term" value="C:sodium:potassium-exchanging ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1660">
        <property type="entry name" value="Na, k-atpase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000402">
        <property type="entry name" value="Na/K_ATPase_sub_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038702">
        <property type="entry name" value="Na/K_ATPase_sub_beta_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00287">
        <property type="entry name" value="Na_K-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="377"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="448"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="499"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="535"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="562"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="595"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="621"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="691"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="721"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="798"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="832"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="901"/>
            <end position="923"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAE1324844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1105" mass="127111" checksum="6F7E93F346CAFA66" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ELW5</accession>
    <name>A0A812ELW5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_73619</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005382">
        <property type="protein sequence ID" value="CAE1323808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ELW5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="388"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="444"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="471"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="502"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="532"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="563"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1323808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="623" mass="71022" checksum="60C8038C18ABC59F" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ELX4</accession>
    <name>A0A812ELX4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_78449</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005540">
        <property type="protein sequence ID" value="CAE1328838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ELX4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="325"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="348"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="377"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="412"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1328838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="433" mass="51640" checksum="8D80B316934AE5F5" modified="2021-09-29" version="1">MLLVLFRLPFFFHNPPMHFPSQSLSIYLSIVSSSFFLSLSHSLSLSFSIILSLSFYLFSFFLCCYTFSSILALLSILIFSFFLPFLFPSFFSFLSFFSFFLLIIKLILLKFNLLIFFLSFLYFIIILSRLINFGCLFYDLFLSRINILDFLFYSSCLDFYFLLSTCLCFFPFNLLTRSPPIHSLLSIFISLSFFSLFAFIYLVFQFPFFLSFFSIFSRLSFFNFFSFFLSFLSFFSFLFFSLSIFLSFYYFIHLFFMSSFFLPLFSPFLFLFLVSFPSFSFFFFHFLFSSFLFFLHFCFLFVSLSFLSFFLSFCLLYMQSLSSSLINISTLNSSLFLFFLSHSVSHRYYFIEMLFHSFLLYLSLSLYISLSLSTSQFYLFLFISSSLFFVFFSFSLSFFVYPFLPSVHLPSLFQTFFTCIFSPMYQISLFSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EM60</accession>
    <name>A0A812EM60_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_73781</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005392">
        <property type="protein sequence ID" value="CAE1323972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EM60"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1323972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="274" mass="32457" checksum="55CBB1E965FB42EB" modified="2021-09-29" version="1">MGLFILFIAFFFSLFTNSILSIYLSIYLSIYLSIYHLSIYLSIYLFQFLSIYLSIPISFFRSFYLSIYSSFYLSIYLSIYLSIYLSIYLSIYLSIPVSFFLSIYCSFFLSIYPNIFLSIYPNFYLSIYLSIYLSIYLSIYLFIYSSFFLSIYLSIPVSFFLSIPISFYLSIYLSIYLSIYLSIYPNFFLSIYLSIYLSIYLSIYLSIYPSFFLSIYLSILVYFYLSIYLSITVSFFLSNPLLSLSLFLYLSHTYLSIGPRFEFLVSSTEKQLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EPG6</accession>
    <name>A0A812EPG6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_76413</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005489">
        <property type="protein sequence ID" value="CAE1326913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EPG6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1326913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="388" mass="41731" checksum="5FB85DCA38A5D25E" modified="2021-09-29" version="1">MDSRESDLFLHMDVSGFNSSIFHIPLIGEIDILQYKFLFSGLLYILICKWALPYLSLSISLPPLTPLPLSHPYLPLFLSPLSVPLSPSLPFSLPYSLSLSLSPYLSNLLSLPLSPSLSSLSLYPSLSLFTSLSLSPTLSFSLTLSLPISLSLFLSLSLPLSPLSLSLSPLLSLPISLSLFLSLSLSLPSLLSFLSLSLSPYLSPSLLTLSSSLFPPPLSLPFLSPLSLLTLSFSLSLNLSPLLSLSLSFSLSLPYSLSSLSPSLPPSPSLPSLYPFSLLSFSLSFSLSLSLTLSPSLSPSLSPLLSLPLFLSLPYSLSLSLSYSLSLPYLSLSFSLSRLHSCIFLYPFLPPSITLSLSSFLSIFLLLPLSLSHALFLSLCPLSVLSIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EUH3</accession>
    <name>A0A812EUH3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_79046</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005555">
        <property type="protein sequence ID" value="CAE1329494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EUH3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1329494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="211" mass="24662" checksum="1C8520911C8229E1" modified="2021-09-29" version="1">MGQCRAFILQKCCSFELSIYLSIYLSIYLSIYLSQPFHAISFFISIYLSIYLSIYLSISFSSYLSIYLSIYLSIYPSIYLSIYLSQSLHIYLSLHVYQSQSLHIYLSIYLSIYLSIYLSISLHIYLFISSCLSIYLSPHIYLSIYLSIYLSIYLSISIYLSLFISIYLFMSINLAVSSYLSIPVDIYLSLFFSIYLSIYLSIYLSIYLTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EVU8</accession>
    <name>A0A812EVU8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_78677</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005547">
        <property type="protein sequence ID" value="CAE1329116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EVU8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1329116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="152" mass="17943" checksum="C220D31AB9629C77" modified="2021-09-29" version="1">MVFHSFLKSRHLSPSLHFFWPFYLSISLSLQLFTLYFQMIFLSFCWPSFPSFYFSLFLSRSLSLSLYFFQNLNKQTIFVISGSVVFFSLSLSLFQCLSLPHHFVFIQLHSIFQCGFFLVLFGWPPSWQITRRPATNSKRDAGKRFSPIGQLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EXU1</accession>
    <name>A0A812EXU1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_79588</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005573">
        <property type="protein sequence ID" value="CAE1330281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EXU1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="287"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="309"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="344"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1330281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="373" mass="43439" checksum="FF612E9235A81D4E" modified="2021-09-29" version="1">MITYLLYSVLFFFIIILSFLFSTQTQFHTLSGCNRGIHFLLLFVLPFSFLPFSSVDSSVYKPTQCNRDVHFLPLFGFLLSFLLLLYTIQLITEVYTFFSGFPLSFLYTIQLVTEAYTFFLSLVFFFSSHDSTYNRDICFLLWFSFFFKRRLNPQRINFSESSIWGSRTGILLVIFLVRSCLFFPIYLSIYLSAFHYLSIYLSIYLSIYLSIYLILSVHIYLSILVCPHLSIYLSIYLSIYLSITVSFLSIYLSIYLSIYLLLIIYLSIYLSISIYLSIYLSITVSGLSIYLSIYLSIYLSIYVPHTHYVVTVTSSSLSIYLSIYLSIYLSIYDSLGARSLTNSVHYLSIQFSQFTIYLSIYLSIYLSTTVAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EYJ7</accession>
    <name>A0A812EYJ7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_80996</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005617">
        <property type="protein sequence ID" value="CAE1331870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EYJ7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032451574" evidence="2">
        <location>
            <begin position="18"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="274"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1331870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="301" mass="34770" checksum="53F975C25A3D77A3" modified="2021-09-29" version="1">MLLLPFLLLTLCPPLLSLSLFLSFYPQLPLLFYASCVMSSTSFLSFWLPNLCKIFFSISIICLSSTFLLPRPSLSIYLSIYLSIYLSIYLSICLSLSLSLSLSFSLSIYLSISFFLLSVLSSTSPHHSLYNFSSSTLHLFYLLITFSFAFFFFIFQAVSLSLSLSLSIYLSIYLSIYLSISLPLSISLSFSPLPRCFTSLLTHQHQKDVMKAENLPCHYLNTKFKHFFHKQILIRNGTLTFIYLSTYLPIYLSYSVHIYLTMYLSHSVQIYVCMYLYTYLHIYLSIYLSIYLSIYLSISFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AIP2</accession>
    <name>A0A812AIP2_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Amino acid transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SPHA_98</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000001">
        <property type="protein sequence ID" value="CAE1137448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AIP2"/>
    <dbReference type="OrthoDB" id="5877963at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015501">
        <property type="term" value="F:glutamate:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015175">
        <property type="term" value="F:neutral L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3860.10">
        <property type="entry name" value="Sodium:dicarboxylate symporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050746">
        <property type="entry name" value="DAACS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001991">
        <property type="entry name" value="Na-dicarboxylate_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036458">
        <property type="entry name" value="Na:dicarbo_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11958:SF63">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11958">
        <property type="entry name" value="SODIUM/DICARBOXYLATE SYMPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00375">
        <property type="entry name" value="SDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00173">
        <property type="entry name" value="EDTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118215">
        <property type="entry name" value="Proton glutamate symport protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0769">Symport</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAE1137448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="331" mass="39140" checksum="C575F660860FE527" modified="2021-09-29" version="1">MGQQGRPLHDFFGALSIVSIKITRIVILNIYLSIYLSIYLSIYLSILECSYFSLFLSLSILACSYFSLCLTLCYKFYLLYLISIYLSIQCSHRSLSLSLSLSLSKTISSHLYSPVGIFFLVAAKVVEVEFPQLTFYRLLMYTITVLVGLLGHGFVILPLVYFLMTRKNPIPFVYGISQGIITALSTSSSTIVFFIFFCPFTFLSFFFFVLFLLLAFFFFVLFLSCPFSFFCPFYFLTFFFFILFLFCPFSFLSFFFFNLFHFCPFSFLPFFFFFALFIFLSFFFFVLFLFLSFLFFVLFLSCPFYFFYPFYFLPFFFFALFHFCPFSSYFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ALZ6</accession>
    <name>A0A812ALZ6_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SPHA_1629</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Farmed</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="EMBL" id="CAHIKZ030000046">
        <property type="protein sequence ID" value="CAE1145350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ALZ6"/>
    <dbReference type="OrthoDB" id="7851174at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23793">
        <property type="entry name" value="UBCc_UBE2E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000003">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 E3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="8">
        <location>
            <begin position="8"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAE1145350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="154" mass="17225" checksum="E9D20887EA6A2E5C" modified="2021-09-29" version="1">MECSLSSLSTPILQRELAEITVDPPPNCSAGPKGDNLYEWVSTIFGPKGSVYEGGVFFLDIHFTNDYPFKPPKVTFRTRIYHCNINNQGAICLDILKDNWSPALTVSKVLLSVCSLLTDCNPRDPLVGSIATQFLTNREEHDKTARQWTKKFAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812APA7</accession>
    <name>A0A812APA7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">KRAB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SPHA_1462</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000040">
        <property type="protein sequence ID" value="CAE1144259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812APA7"/>
    <dbReference type="OrthoDB" id="8922241at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000065">
        <property type="entry name" value="B-cell CLL/lymphoma 6, member B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001732">
        <property type="entry name" value="Zgc:162936"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000744">
        <property type="entry name" value="zinc finger E-box-binding homeobox 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000417">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zinc finger protein 236"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="zinc finger protein 319"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="Zinc finger protein 697 isoform X1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="13"/>
    </dbReference>
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        <property type="entry name" value="Znf_C2H2_sf"/>
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        <property type="entry name" value="Znf_C2H2_type"/>
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        <property type="entry name" value="EXPRESSED SEQUENCE AW146154-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24390">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="7"/>
    </dbReference>
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        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
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    </dbReference>
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        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="13"/>
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    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="311"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
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        <source>
            <dbReference type="EMBL" id="CAE1144259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="769" mass="89546" checksum="844D86C03C49846B" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AQA1</accession>
    <name>A0A812AQA1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_2767</name>
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        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAE1149570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="179" mass="21107" checksum="48B5A23D2E70C7B6" modified="2021-09-29" version="1">MPHSLHIYLSIYGILFISIYLWHSLHIYLSIYLSIYLSMPFSLYLSIYGILFISIYLSICHMHSKHIYLSIWHSLHIYLWHSLHIYLSKAFSSYLSIYLSMAFSSYLSIYLSIYGILFISIYGILFISIYLSMAFSSYLSIYDILFISMTFSSYLSMPFSSYLSISFSSYLSIYLSIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AQJ7</accession>
    <name>A0A812AQJ7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">SPHA_4836</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="protein sequence ID" value="CAE1156583.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
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        </location>
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        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="607"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1156583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="633" mass="73987" checksum="537966638A7E2BC8" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ARL1</accession>
    <name>A0A812ARL1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_5472</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000181">
        <property type="protein sequence ID" value="CAE1157941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ARL1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1157941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="318" mass="36823" checksum="7804339BD9242958" modified="2021-09-29" version="1">MYRVRWPSSEIIVCTVLYDPDAYVCDTVLPRHVPVTCSHSIEQLLFDSEARYLMPTNFLLLVIFSIYLSIYLSIYLSICLVCFVLRHINLNGLFNADKIFIAGNIFYLSIYLSIYLSIYLSIYLSQYIYICRHFFVNNDDMSGIKFFFFFFFFFFFFSSSSSFFFLLLLLLLLLLLLLLLLLLLLFYLLPLLLLFLLLFLPHPSSSSSSSFPPPPSSSSSSLPPSSSSSSSFFLLLLLLLLLLLLYLLLLLFSSSSSSSFFFFFYFFFFFFVWYQKIPVSTAVIKDDFSLKVPFTQAKHFDRTLNGISIGLSKEVTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ATQ9</accession>
    <name>A0A812ATQ9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_5488</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000181">
        <property type="protein sequence ID" value="CAE1158044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ATQ9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1158044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="231" mass="27797" checksum="CF9FA9FC0977D2DC" modified="2021-09-29" version="1">MSIHYDHTYSNLSIYLSIYLSLFIMAIPIQIYLSFYVDSLSIYLSIYLSIYLSKRPSIYIYLSRKPSIFIYLFIRFFISVCILIYLSNNLSIYLSIYLSIYLSIYLSDHSYLSIHQSTYIYLSIILSDYSYLFIYLSNHQYLFNSFFFTISIIHISKFIHMYLSVSVSIYLSIYVYSLWPYLFKSSYLSFYVDSLSIYLSMSIHYVYTYSNLFIYLSIYLSIYLSIYRYNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ATW1</accession>
    <name>A0A812ATW1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_4949</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000162">
        <property type="protein sequence ID" value="CAE1156828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ATW1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134:SF22">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134">
        <property type="entry name" value="OS08G0543275 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1156828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="205" mass="23446" checksum="E173AF4ED8B0C57F" modified="2021-09-29" version="1">MNGSTDLSIYLSIYLSMYVCMYVCMYVCMYVRTHLSTNLPIYLFMYVCMTVSIYLSIYLSIYLFIYLSNINRGSGGQRRRGTLASNATITMTRSMTLRSVIGVLEHSFSSYSSHFLCLLFLSDSLSYFFLPLIIFFLFLSLFSDCIYLLFHFPSLAFSSCSSLPSLSCLFFQPLTIIFSFNITLLSLLSSFLFFSASAFFLTILP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AUF2</accession>
    <name>A0A812AUF2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_4045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000124">
        <property type="protein sequence ID" value="CAE1153877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AUF2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1153877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="297" mass="34407" checksum="9671D4E4F549E93F" modified="2021-09-29" version="1">MCACAHTHTHACARTHTRACAHTHILFKSIYLFHSVHIYLSIYLSHSAHIYISIYLSIYLSISFCSSSIYPSIYLSLFISIHSSIYPSIYLSLFISIYLSIYLSIYLSHSAHIHSSIYLSSIYLILSFIYLSIYLSIYLILLISIYLSIYLSIYLSLFISIIYLYIHLSISVCSYSFYHLSIYSSIHLSITFCYISIYSSIYLSISFCSHLSIYIYLYLSISVCSYLSIYLSIYPSIYLSLFLSIYLSIYLSIYLSHSDHIYLSIYLSIYLSIYLSITFRRPVSDDKPHPAARPLIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AUY7</accession>
    <name>A0A812AUY7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_5969</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000197">
        <property type="protein sequence ID" value="CAE1159508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AUY7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="329"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1159508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="412" mass="50870" checksum="8B46ED1BEBD6E9E2" modified="2021-09-29" version="1">MFSFLFYYLCVFRSVSFFLFQFLSFFLSMYLFLSISFFVYFLFIIYACFFRFFLIFYLFFYFIFLSLFSLRLFLFIFFVYLFGIVVNLFFYISLFLSFFLSFRITFFILFYITSSNVFLNLALSYFSLAIISVGFFLLSISFFLFLSLSFFPCLYDIFPFNTSAYFFSFTSIFLCIFCYTLLSLPFHIFRSLHLKCLSFLLLFSFFVLISFSLFPFLVSFSIVHFILFYFCTSFIYSLFTFLFLCFLYLFFFLFSFLFFCFPFFSFPLFFVFVFLFPIILLISHTFFFVHIRHFFSFIFSLYISFSFLFFLIFLFSFPFLISFSLSFFWLPYLFPLFFFSFFFLFFFFLFFYPFFSRFTLLYLLHLFARFNFFLSFLLFFFSPSISFSFPFPFSSFFYRSFFSCSLFYKHDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AVI1</accession>
    <name>A0A812AVI1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_5795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000190">
        <property type="protein sequence ID" value="CAE1159013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AVI1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1159013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="196" mass="22894" checksum="0D6D1CC79D1ED762" modified="2021-09-29" version="1">MIYLSIYLSIYLSIYLSIYLSIYLSQPLNTCLPQSVHYLSTYLSIYLSIYLSIYLSIYLIIFSNFGETTLTFKQSDQLFKTIHPSTTNFCHISIYLSIYLSIYLSIYVCSNQSTFVKIYLSKSVQINQSIYLSHSVQYLSIYLSIYLSIYLLSIYLSIYLSIYLSIPVCSISIYLSIYLSIYLSIYLSRQIILCHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AVY7</accession>
    <name>A0A812AVY7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_6064</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000200">
        <property type="protein sequence ID" value="CAE1159657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AVY7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1159657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="243" mass="27605" checksum="0CC8CAFA911984A0" modified="2021-09-29" version="1">MSWEEIRPDVPGEGKEMSSGKGMRSVVQMPWECTDHVWKIKHSYKYKYIHKTIYLSIYLSIYLSIYLSIYLSIYLSIYTYTYTHIMAGCCWFLTSHLSNLLSFYLSSLSLLLFSLSFSLSLSSLFSLSFSLLSLLLSLSLLFSLSLLFSLSFSLSPFLSLLFSLSSSLSLSFSLSTSLTLLSNTIFLHSIIHSHPLLLLSLSFFLSHSLSFLSVSISFDCITLPFPNSFHFFLFPQLLCSSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AVZ8</accession>
    <name>A0A812AVZ8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_5373</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000180">
        <property type="protein sequence ID" value="CAE1157861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AVZ8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="202"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="253"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="312"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="341"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="365"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="396"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="424"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="460"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="511"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
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    </feature>
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            <begin position="689"/>
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        </location>
    </feature>
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        <location>
            <begin position="718"/>
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        </location>
    </feature>
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            <begin position="749"/>
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        <location>
            <begin position="809"/>
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        <location>
            <begin position="845"/>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="885"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="919"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="955"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="985"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1012"/>
            <end position="1035"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1157861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1036" mass="127583" checksum="FCB6FB98F0A0DD09" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AXB2</accession>
    <name>A0A812AXB2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_6838</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000223">
        <property type="protein sequence ID" value="CAE1161403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AXB2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="72"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1161403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="251" mass="29364" checksum="254163E2A7B22C55" modified="2021-09-29" version="1">MFYMYFPDKTIFFFFFFFFFFFFFFFVAFFLFFFCSAFYFSLDFLIFFFPVFGLLLLLSSPSFISSSSFFIFSSSSPPPSSSSFSSSSSVFIFLLLFSSSSSSSSSSSSSFSSSSSVFIFSFLFFFFIFFFSSFSSFSFSSFSFFFFFFLFFFFCFYFFLLLSSSEEYLFTLFCLYLLAASYFQSLLFFLFFLLSFFLFSELPTRLFYSSFFAIASKLKASASFLQLHPPPPLSLAQVYTSGNVLSNLFLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B0R6</accession>
    <name>A0A812B0R6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_8171</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000263">
        <property type="protein sequence ID" value="CAE1164787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B0R6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        </location>
    </feature>
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        <location>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1164787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="205" mass="23786" checksum="88EE792718A7B4C9" modified="2021-09-29" version="1">MFSLSPSISLSISLIFTIAPSVSLSLCFPFSLPPFLPLTVLPSFSFLLSLLPSLYLYPSLSLSSSLSLLHSLFSFSPSIVNYLNRNLTFFFFFFFFFFFFIISSFFFYFFSFLFLFFSSSFFSFSSSSSSSFFLLLLLLLFLSRLLLLIIFRLFFVLFFFFFFFFFFFFSTSASSSFSSPSKSPLFSLSFSCFLTLSFFLSFVPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B167</accession>
    <name>A0A812B167_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_9484</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000302">
        <property type="protein sequence ID" value="CAE1167475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B167"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
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    </dbReference>
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            <end position="26"/>
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            <end position="53"/>
        </location>
    </feature>
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            <end position="85"/>
        </location>
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            <end position="173"/>
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        <location>
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            <end position="200"/>
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            <end position="230"/>
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            <end position="273"/>
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            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="464"/>
        </location>
    </feature>
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        <location>
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            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="495"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1167475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="559" mass="66286" checksum="3EFCB2717F581C47" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B246</accession>
    <name>A0A812B246_ACAPH</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_9438</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000302">
        <property type="protein sequence ID" value="CAE1167450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B246"/>
    <dbReference type="Proteomes" id="UP000597762">
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    </dbReference>
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        <location>
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            <end position="28"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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    <feature type="transmembrane region" description="Helical" evidence="1">
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAE1167450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="403" mass="47910" checksum="67296E77BFF5938C" modified="2021-09-29" version="1">MTKNILCCHIFHLSSIYLSIYLSIYQSVHYLSISSFHLSIYLSIYLSIYLSIYLSIYLSQFIIYLSIYLSIYLSISIYLSQFIIYLSIYLSIYLSHLTLPPFFPPQSLETRTIPTPSISPSPLSPCSFGLLFLIRSRTVPMQNTCTQPSHNMAAVDALRYFIVRSHFIETIILTGELSLPLTTPLYIFLSFFLSFFLSFFRYCVYAILFFLSSLRNDIFFFLSLFFRSLMRISLSHLSFFQSFYLFPFFIAYPPFLSFIHSLFVCFFLSFVSAFYFILSFILSFCLSFACTFCFIRFSFTAYRPFLSFFFLSFFLSFFLSFFLSFFLFLCVFLSFFFLSFFLLYPLFLSFCFHFVISFFLFAYLICLSFFFSFLFSLLRIRFSFFLSFFLSFFLSLLPLRLFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
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    <name>A0A812B2V2_ACAPH</name>
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        <submittedName>
            <fullName evidence="5">Protein furry,Protein furry homolog-like,Protein furry homolog</fullName>
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        <name evidence="5" type="ORF">SPHA_9245</name>
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        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000295">
        <property type="protein sequence ID" value="CAE1167133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6287725at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025614">
        <property type="entry name" value="Cell_morpho_N"/>
    </dbReference>
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        <property type="entry name" value="Furry/Tao3/Mor2"/>
    </dbReference>
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        <property type="entry name" value="MOR2-PAG1_mid"/>
    </dbReference>
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        <property type="entry name" value="FURRY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14228">
        <property type="entry name" value="MOR2-PAG1_mid"/>
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    </dbReference>
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    </dbReference>
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        </source>
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        <source>
            <dbReference type="Pfam" id="PF14228"/>
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        <source>
            <dbReference type="EMBL" id="CAE1167133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B3I0</accession>
    <name>A0A812B3I0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="2 3">
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        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
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            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
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            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000300">
        <property type="protein sequence ID" value="CAE1167350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B3I0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134:SF22">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134">
        <property type="entry name" value="OS08G0543275 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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    </feature>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="423"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="449"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="487"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="511"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1167350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="530" mass="61931" checksum="292A8E8E8A36CB9C" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B4R8</accession>
    <name>A0A812B4R8_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SPHA_9849</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000313">
        <property type="protein sequence ID" value="CAE1168056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B4R8"/>
    <dbReference type="OrthoDB" id="9990906at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF230">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="339"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="107"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAE1168056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="361" mass="40263" checksum="594FDD7F9C090D61" modified="2021-09-29" version="1">MVNTYFPSTSSPFLFTLPTSSLLSASPSSSVFSSISFRKLDDQSLADYTSWSPNNNQRRNLVTSENGHETSFNNESISSVNFYWEHRVATIINLYVPPFLVILGTICNCLVVLVMAGHWFSSVSTSVYMISGTIADTASLLIALPAHWVYVNFPDSIQRSEHSHIMCKFFNFFGWGSSDYGIILTVAMTIDKAIAILFPIKAQANCTTKRSKRVIFILFIFIVIKESHFLFVSNIVPPGRTEQLCTIDIPNDDQEVAQLQGLQRVETLVPGNGSLQKPADHCHVARRVLHPRHLDAAILAARDHHQQQPNGAAFDSVQPVGVRHRLLPAVREQTLSNTASIYLSIYLSILCVSYLFPVREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BAC7</accession>
    <name>A0A812BAC7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_13729</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000461">
        <property type="protein sequence ID" value="CAE1175613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BAC7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="297"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1175613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="371" mass="44013" checksum="458AD112FC584C00" modified="2021-09-29" version="1">MSSFLSVFSIVFFFHSFFLSFFLIQIGFSPPTALNSHLFILIFIMSLFFPSFLCSFFFLSFFLSFFLSFFLSFFLSFLFKMDFSSLTALNSHFLSFSFFLSFFFFLFLSFFNIILFSFFPSPFKSFAFFLTDHNIFFLAFSLFFQIPIRFYFLFPSLDLSSLFPTSNFSIFLTYRHLYIFLLFLFSLFPPTSSYTFLFFSFAFVFLSHSHFPFYFAPHSFLSLFLSFSIPFLPPAVFSFFLSFFIKYSSLPLFLIFLVLAPSHSRSFLPSSFLFVHGLLPFSLLSFVYFVHSLIDSPFFLISSSFISFILFIFFFFLYFFSPLLLTFYSFFLCHLPLHREGPFEDTTTKKHLCTPDISVHPHLNSWYTPYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BBL0</accession>
    <name>A0A812BBL0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_16772</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000595">
        <property type="protein sequence ID" value="CAE1228379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BBL0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022324">
        <property type="entry name" value="Bacilysin_exporter_BacE_put"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01988">
        <property type="entry name" value="EXPORTERBACE"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="342"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="380"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="409"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="432"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="469"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1228379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="493" mass="59554" checksum="D4C023A9A720B5FD" modified="2021-09-29" version="1">MHCNCHPINFYLSIYLSIYLSIYLSIYLSISVGLLSIYLSIYLSIYLSIYLSIYFRRFVSMYLFVYLSIYLLQFVRYLSVPHLSVYLPHSVRYLSIYLSIYLSIYLSIYLSISFCSFLSIYLSIYLSICLALVLSVYFFSFFILLIHHFSFSFTSLSFITEELLVLVLLSVPYSFQKFFFFLFFVDYSFKIIFFLSSVTYSFIFFISLFIPFYASFPLITFFLSFVPYSFLSFFLSFFLSFFFSPLFIFIYYIYFFLYISLYLFLSFFLSFFLFSALYAFLYCFSSTSSLIPFYITLLPLFLPLLTLFIPFFLSFFLSFFLSFFLSFFLSLQPLFICFFLSLLLLFVSFFLSFFLSFFLSFFLSFFLYNLYSSVSFFLSFFLYYFCSSLSFFLSFFLSFFLFFTTSIHLFIFFFLSFFLFSFFLYYSCSSFFLSFFLSFFLSFFLSFFIAPIHFFLSFFLYCPYSFLSFFLSFFLSFFLFSFLSFFLSFPFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BEV0</accession>
    <name>A0A812BEV0_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="2">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">SPHA_16220</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="25">Farmed</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Receptor for basic fibroblast growth factor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="2"/>
    <dbReference type="EMBL" id="CAHIKZ030000568">
        <property type="protein sequence ID" value="CAE1226900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BEV0"/>
    <dbReference type="OrthoDB" id="5984265at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
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            <dbReference type="ARBA" id="ARBA00056965"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        </source>
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        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
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        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAE1226900.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1269" mass="149797" checksum="2C08BE22965D2CA2" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BFD3</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
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    </reference>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="365" mass="42418" checksum="DCDBAD76C8CF352C" modified="2021-09-29" version="1">MTEVPSLWNWGGVGMINHPRPFWINSPPLSCYLSNSVTFITIYHIIYNIYFIYSLSIYLLSIYLSIYLSFRGVCTPVCLSLSLSPSPSLSLSSPSSFSLCRFFFLFLSAIHAFELSFFFLFSFNFIKSFFLVFFHCLSLSVVIFLISFIFFFSIIFHLFLFLQSFSLSFFPSLFCFEFSFFLFFLFFLSFLFFEQVYYLALHFFILLSVISLPLSLSFFSFSFVLSLSLSLSLCFSAPLSQLSFSLSFSHSFSLSSSLSLFLSAVLISFAFTSFNYFYIFLHSSSFFSFILIFVFLAFFFIFFFPFSLPPLSLSLSLSLSLSKLSLFLSLFLFLSPYLCHYFTLSFQPSFFSNSFYHSTYISFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BFJ8</accession>
    <name>A0A812BFJ8_ACAPH</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        </lineage>
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            <authorList>
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                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
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        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
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        <location>
            <begin position="984"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1227793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1030" mass="122736" checksum="A5A6672F1DDAA0E3" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BG86</accession>
    <name>A0A812BG86_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA replication licensing factor MCM5</fullName>
            <ecNumber evidence="13">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SPHA_15533</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Farmed</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="13"/>
    <dbReference type="EMBL" id="CAHIKZ030000541">
        <property type="protein sequence ID" value="CAE1224866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BG86"/>
    <dbReference type="OrthoDB" id="10036721at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17756">
        <property type="entry name" value="MCM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000032">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1640.10:FF:000006">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000241">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008048">
        <property type="entry name" value="MCM5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054125">
        <property type="entry name" value="MCM5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF42">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21933">
        <property type="entry name" value="MCM5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01661">
        <property type="entry name" value="MCMPROTEIN5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 13" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 13" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 13" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 13 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="14">
        <location>
            <begin position="276"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU368063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAE1224866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="679" mass="76175" checksum="008B2ADCE07BC937" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BI39</accession>
    <name>A0A812BI39_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_17940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000644">
        <property type="protein sequence ID" value="CAE1230991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BI39"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1230991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="178" mass="20183" checksum="5A44B25CF0A3BAC3" modified="2021-09-29" version="1">MEKWDGKKKKVNPFSFPIDRHISLSLSLSLSRCISNSENPEEQEEGAVKVGGRERERERTLLLDIIYSILPDAIYSRHKQLIVYPDPKSYGWESSSSVSSNAYTPKDEHKKIGKIKGKIVCSQVNGPVSRTLGQSLLLQQQLRKCRDPCCTTVDVPERGSPPVCQCWSHGSIVKWLWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BIH8</accession>
    <name>A0A812BIH8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_19259</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000700">
        <property type="protein sequence ID" value="CAE1234247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BIH8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039715">
        <property type="entry name" value="ZCCHC10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13491">
        <property type="entry name" value="ZCCHC10 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13491:SF0">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="304"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="341"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="375"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="405"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="432"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="474"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="503"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="534"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="563"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="608"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="633"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="660"/>
            <end position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1234247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="680" mass="81593" checksum="B84BB0B7EE9ED66A" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BLT7</accession>
    <name>A0A812BLT7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_19722</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000716">
        <property type="protein sequence ID" value="CAE1235268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BLT7"/>
    <dbReference type="OrthoDB" id="1421090at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1235268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="352" mass="41843" checksum="48CB5A5B4B37C043" modified="2021-09-29" version="1">MSLNPNVGSPAKKFKSQRSTRKVMLTVFWGHMQGPITISFLEKESTSLHYLSIYLSQSVLIYLSIYLSIYLSIYLSIYLSMLSIFYLSLFLSLSIYIYIYIYIYIYLTKSIYLSIYLCLFISIYISIYHNVFLFKSIYLSIYLCLFISIYISIYHNVFLFQSIYLSIYLSLFISIYISIYHNVFLFKSIYLSISVYIYLYIYLSIIMSFFSNLSIYLCLFISIYISIYHNVFLFKSIYLSIFVCLYLSIYLSIITSFFSNLSIYLSIYLSIFVCLYLSIYLSIITSFFSNLSIYLSLFISIYISIYHNVFLFKSIYLSLFISIYISIYHNVFLFKSIYLSISVYICLYIYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BP05</accession>
    <name>A0A812BP05_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_20877</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000766">
        <property type="protein sequence ID" value="CAE1237678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BP05"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="304"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="338"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="369"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="401"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="432"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1237678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="468" mass="57268" checksum="DB4DC48A5A683966" modified="2021-09-29" version="1">MNTTSIYLSIYLSISFCFSIYLSIYLSIYLSIYLSHSVHLSNYLSHSIYLSIYLSIYLSKSVFLLIFIPFYPSHSFFPSLFLSFCFFFLSFFLSFFLSFFLSFFPTPQHLLNFSFFIHLLLLFYPFILSFLPFLAIPSAVICFYRSHLSFFLSFFHSFFLSFFLSFFLSFFLSHPSKIFLIYLYFIYYFFSITSFLLSFFLSFFLSFFSDIFSFFFLSFPTFFHFSFFLFRHFSFFFLCFFLCLFFLSFFSDIFSFFFLSFFLSFFLSFYLSFPTFFIFLSFFLSFPTFFIFLSFFLSFFLSFFLSFFLSSFSLFFLCFSFIFLSFQNFFNFFLSFPTFFHFSFFLSFFLSFPTLFIFLSFFLSFPTFFIFLSFFLSFFLSFFFFSFLSLFFIYFSFIPKFLQFLSFFLFRHFFIVLSFFLSFFLSHPSKIFLIFLSSFIYYFFSITSFLHSYFLSFFLSFFLSSHIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BQ43</accession>
    <name>A0A812BQ43_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">hydroxyacylglutathione hydrolase</fullName>
            <ecNumber evidence="5">3.1.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glyoxalase II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SPHA_20148</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Farmed</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an S-(2-hydroxyacyl)glutathione + H2O = a 2-hydroxy carboxylate + glutathione + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21864"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58896"/>
            <dbReference type="ChEBI" id="CHEBI:71261"/>
            <dbReference type="EC" id="3.1.2.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.6" evidence="5"/>
    <dbReference type="EMBL" id="CAHIKZ030000739">
        <property type="protein sequence ID" value="CAE1236213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BQ43"/>
    <dbReference type="OrthoDB" id="515692at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004416">
        <property type="term" value="F:hydroxyacylglutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019243">
        <property type="term" value="P:methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07723">
        <property type="entry name" value="hydroxyacylglutathione_hydrolase_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000019">
        <property type="entry name" value="Hydroxyacylglutathione hydrolase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01374">
        <property type="entry name" value="Glyoxalase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035680">
        <property type="entry name" value="Clx_II_MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032282">
        <property type="entry name" value="HAGH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017782">
        <property type="entry name" value="Hydroxyacylglutathione_Hdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03413">
        <property type="entry name" value="GSH_gloB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11935">
        <property type="entry name" value="BETA LACTAMASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11935:SF94">
        <property type="entry name" value="TENZING NORGAY, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16123">
        <property type="entry name" value="HAGH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="10">
        <location>
            <begin position="69"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAE1236213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="382" mass="43110" checksum="3221ABD7A00214FE" modified="2021-09-29" version="1">MILSSTVYRITLGFRCISISSSSAIFRNCLRTTRATTAFENLCRTSFHSSQVIVSQKDMKIRLLPALKDNYMYLLIDEGTKLCAAVDPVEPQTIMSAVQEEGVKLTTILTTHHHWDHSGGNVGLVKLVPGLDVLGGDERIEALTKKVTHGDEIKLGSLNIKCLFTPCHTTGHICYFVTSEDFEQPAVFTGDTLFVAGCGRFFEGNPQQMYHALIEVLASLPHNTRVFCGHEYTINNLKFAAHVEPNNKAIKDKMVWSKSQRDKNCPTIPSTIGEELLFNPFMRVREETVQHHSGCIDPIESLPKTTKPQKTVRSRTTRTPLMRTPTAFVYGIISFHWSTVYARINERFLSFFLSFPAENLRCRLVLPFSSLQRQYLESGKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BQ73</accession>
    <name>A0A812BQ73_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_20777</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000763">
        <property type="protein sequence ID" value="CAE1237470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BQ73"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1237470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="206" mass="23905" checksum="F9274D2528450E1F" modified="2021-09-29" version="1">MASFDAFLSEGRNIFVLLLIYLSIYLSLFIYIYLCQSVHIYLSIYLSICLLHFVHIYQTICLSLFLSIYLSIYLSIYLSIVVFHIYLSISLSIYVSLFLSIYLSIYLSIAICSYLSIYRSLSYLSIYLSIYLSIYLSLFISIYLSISVCSYLSIYLSIYLSIYLSQSVHIYLSIVVFHIYLSIYLSIYLSLPIFIPGPIQSMNTCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BRF3</accession>
    <name>A0A812BRF3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_21393</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000784">
        <property type="protein sequence ID" value="CAE1238568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BRF3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1238568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="265" mass="32492" checksum="D6DD1A8AD19B9A0A" modified="2021-09-29" version="1">MQDSTPGISDTAQMSLICRYVIVEDKELAERESFLDSFFLLVIFFTLFVVQSFYYHLYFFFLFSLVFPSFLSFIPLSHSFLFLFLLIYFASYYFEPLIIFSFILFRFIHPNELESCFLFSNCHSFFLLILTFSFFLSFFFTHFLLLSFSFFVSFSLSFSFIYIFRFLFLFVFVLVSFFLFLSFFLFLVFYIYLFFFLFLFSFFFFYLFPSFFSAVLSHFFFISFLSIVIHYPFSFSPLLLLILRHFSYAYPFFFIYFCFFQYFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BRL6</accession>
    <name>A0A812BRL6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_21523</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000790">
        <property type="protein sequence ID" value="CAE1238829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BRL6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1238829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="209" mass="24582" checksum="29F5E11EF4A62C36" modified="2021-09-29" version="1">MRRSNLLMIIFYFLPFFPPFFLSFFLSFFLRKKQNKKNYTCRISFIYSFVYSSASFFFLSFFLSFFLSFFLSFPFCALFMVHPLQGPRATRGRELRLEAYLSIYLSIYLSIYLSIYLSSPSFLPSYLSIYLSIYLSIYLSILPSCLPFFLSIYLSIYLSIYLSIVVSLSSYLSLLISIYLSIYLSIYLSIYLSIYLCLNMSILVSSLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BTV7</accession>
    <name>A0A812BTV7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_23941</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000888">
        <property type="protein sequence ID" value="CAE1243666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BTV7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44592">
        <property type="entry name" value="NUDIX HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44592:SF3">
        <property type="entry name" value="SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="227"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="362"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="431"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="475"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="501"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="546"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1243666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="581" mass="65291" checksum="5AFFCDB722F6BF6E" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BU24</accession>
    <name>A0A812BU24_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_22201</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000818">
        <property type="protein sequence ID" value="CAE1240151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BU24"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="391"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="434"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="461"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="493"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1240151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="517" mass="63976" checksum="DB8AEDFACAE1EDBB" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BVS4</accession>
    <name>A0A812BVS4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_24991</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000945">
        <property type="protein sequence ID" value="CAE1246086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BVS4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1246086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="296" mass="34892" checksum="257833E1D60E9503" modified="2021-09-29" version="1">MYIFSLSLLFYSSHFSLSLFLIYFLNLSFSLHLSFFASNIFITLSFSFPLFFLSFPLSLSISFPFISFASITFTFTFCSLTLLFTYSHHLTLSLFSLYLTLLFSTIFIFAHFLLFSLFSHIYILSLFSVIFPLYLLVLLSTIFTFVCFLFSHPHIFSLSFHSYFPLSHHFLLLSTTFIFTFLVSLSLSLNTFPPFFLSLFFPFPFSQTLHFLLSHLLSLILYPTFYLFTTSRDPIHHFFLSYSSSYIYLPYPYPYFFLSFYINFTIFSIFSFLFFSLLIMQPRQNMCHAPLSNPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BWJ5</accession>
    <name>A0A812BWJ5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BRAT1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SPHA_24865</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the BRAT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000936">
        <property type="protein sequence ID" value="CAE1245786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BWJ5"/>
    <dbReference type="OrthoDB" id="6078630at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008283">
        <property type="term" value="P:cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038904">
        <property type="entry name" value="BRAT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21331">
        <property type="entry name" value="BRCA1-ASSOCIATED ATM ACTIVATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21331:SF2">
        <property type="entry name" value="BRCA1-ASSOCIATED ATM ACTIVATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00061308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAE1245786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="706" mass="80396" checksum="D412CF2A63199D48" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BX78</accession>
    <name>A0A812BX78_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_27190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001046">
        <property type="protein sequence ID" value="CAE1250595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BX78"/>
    <dbReference type="OrthoDB" id="8964543at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1250595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="175" mass="21687" checksum="E43955F4D852C50F" modified="2021-09-29" version="1">MGQTTRFSSDSLEQIVDKAVHDGHGFTGNAGIGMNLFHHFVDVDRVAFFPLMFHFLAIGPDSFRLVKKRFLSNFKNYSRFTFFIFSFSYFFFFLSFFFFFLFLFLHIFFFLFLFFYMSFLFSLFAYFLFFFFFLRIFFLFAFYIFSFFLFTYFLFSFLHIFFFLFFSFYIFSFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BXR1</accession>
    <name>A0A812BXR1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_24146</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000897">
        <property type="protein sequence ID" value="CAE1244084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BXR1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="37"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="346"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="382"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="438"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="489"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1244084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="534" mass="61941" checksum="1CBE4D53EDB333EA" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BZ33</accession>
    <name>A0A812BZ33_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001021">
        <property type="protein sequence ID" value="CAE1249725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BZ33"/>
    <dbReference type="Proteomes" id="UP000597762">
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="189"/>
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            <end position="238"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1249725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="268" mass="31162" checksum="31D531FB3EA5112D" modified="2021-09-29" version="1">MNHFSSECLQSLFKKLVYIYLSTYLFLLLSLSIYLSPLRRLYLCLNICMYVCMYLSISSFIYLSLYLSVSSSSSISIEITAFSAIISGNNYVDNLSIYLSLSFDIYLPIKSFSYLFQALYIYILFSSYLSIYHSLFIIYLYIYVSNSLHSYLSIAQSIYLNIYLSIPVFSLAIYISILCSSYLSDYLSIYLSIYLSLFIISLSLYLSYSLHIYLSIYSKLFICISSFIYLCHSFHIYLSISFDIYLRLSIYLSIYLSSLSVTPCSVFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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    <name>A0A812BZD1_ACAPH</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">SPHA_25679</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
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    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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            <begin position="65"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1247466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="216" mass="25838" checksum="641A8104D5A4A20B" modified="2021-09-29" version="1">MEFILLPFTRPGKEGSFSLSIYRSFSLSIYPPQSFHYLSIPVFSLSIYLSIYLSIYLSICRTQSFIYLSIYLSIYLSQSFLYLSIYLSIYYLQKKKIEYLKYFIYLPQSFHYLSTAVFHFLSIHRSLFLSIYSSLFSIYLSIYLSIYLSIYLSIYTSLFIIYLSQSFLYLFIYPSLFIIYLSQSFLYLSIYLSIYLSIYLSIYLSICRILFIIYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C3R6</accession>
    <name>A0A812C3R6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_29006</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Mollusca</taxon>
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            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
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            <taxon>Acanthosepion</taxon>
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            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001147">
        <property type="protein sequence ID" value="CAE1254505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
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        <location>
            <begin position="120"/>
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            <begin position="147"/>
            <end position="166"/>
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    </feature>
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        <location>
            <begin position="200"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
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        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1254505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="327" mass="39390" checksum="493B7043935DCFDC" modified="2021-09-29" version="1">MLDKLLSFFLSFLSASDLHGLSYFLFSCFLSFFFLSFFFLSFFLFFFLSFFISFCVFYQILIYTVFFLFVSFFFFFLSFFSCILSDSCLSFFEHSFFLFVSFFLSFFIRFLYVRAFFFSFRVFLSGFLFFLSFFLSFFSCLLSDSCIYGFSFFLSFFLSFFSYSCIYMGFLSFFLSFFLSFLFLSVLSASLFSLSIYLSIYLFEFVPIYLSIYLSIYLSIYLSISKYIYLRFFLPIYLSIYLSIYLSISKYIYLRSFYLSIYLSIYLSIYLSISKYIHLRSFLSIYLSIYSSIYLSIYLSIYLNYLSISKYIVPFSIYLSIYLSINI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C726</accession>
    <name>A0A812C726_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_32430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
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            <taxon>Acanthosepion</taxon>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001351">
        <property type="protein sequence ID" value="CAE1260862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C726"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1260862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="306" mass="36110" checksum="1D4D40400437E721" modified="2021-09-29" version="1">MQCSCCSLYLSVYLSLPVLFYLSIYLSIYLSIYLSHLVLYFLSFYLSIFIFVHIIYLSNPVLSFFFLSIYLSIYLSIYLSISFCSYLSTERQYCYQHLALGSQKTTSITVYPHKFNRINLSQSVNIYLSIVSIYLSSCTSLLISIYLSIYLSILLISIYLSIYLSIYLSTFNCKYHLKIVCKYLSIYLSNYLSIYICQLVSIYLHLSVVFFLSFFLSIYLSIYLSIYLSIYLAIYLSIYPVNIYLSIYLSIYLSIYSHLFIIYLSIYLSIYICQLISIYLHLSVVFFLSFFLSFFLSFFLSIYLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C7F3</accession>
    <name>A0A812C7F3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_30915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001249">
        <property type="protein sequence ID" value="CAE1257747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C7F3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1257747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="204" mass="24993" checksum="F95B37E2198C775B" modified="2021-09-29" version="1">MYDYLLFLSFFLKLNLPFFLEFNLPSFLSKIYPFFLPFLLKFNLPFFFLKSNQPSFLSKIYPFFLPFLLKFNLPFFFLKSNQPSFLSKIYPFFLPFFLRFYLLLNLPFLFSFLSFFPKLQPSFLFKLQPSFLFKIQPSFLFKLQPSFLFKLQPSFLFKLQPSFLFKLQPSFLFKIQRFFFFFQKFILTFFLKFILSSNLSLLPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C8C2</accession>
    <name>A0A812C8C2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_33093</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001385">
        <property type="protein sequence ID" value="CAE1262242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C8C2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1262242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="266" mass="33423" checksum="0285351D7D4010CF" modified="2021-09-29" version="1">METICFVYIFFASFSFFSFSILFFCFYSFVFPLFFFIFFLFFFSLLFLQFSFFFFFFSFLLFFFPLFIFISFLQFFFLCLFSFFFFFLFFLHIYFLSSSLFFFFYRLLFFSILFSFSFFNFSSFVFSSFISFILFVLNRLFYPFFLFLFWFFFSLRVLSCSFRFFFILSFFFSFFPYPFPFCFFLFSCVLSIFFSFFMIYIIFSFLQLIFILSFFFIRLHIFFFSVLCMFRHIPLFFFRFSLYAINALSCYHYAKPKMSFMQVCTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C9A0</accession>
    <name>A0A812C9A0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_33626</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001412">
        <property type="protein sequence ID" value="CAE1263226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C9A0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="325"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="355"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="383"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="413"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="441"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="472"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1263226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="503" mass="57376" checksum="F21EFC6875C37FC7" modified="2021-09-29" version="1">MYAVQHPSLSVTGAPSTLGRAHTCKLLFLSASTDLSAITWKRRRGWAAGKIDFLSFFLFFFLWGVGVGEASILVENYHRLLRGGVQFPTLKKKKLLRREKYLGYFFFSLFLSLSLSSLSLSLSLSLSLSLFSLSLSLFISFSPSLSHAIFLSSTSLSSSPATFHFCLHLSISHTFSISVPFSLSISPINFHFCLASVSLSLSLSLSLSLSLSLSLHTYSTHIIFLSMPLLSLSLSLPLSLSLSLSLSIYLSIYLSIYLSISHLYCYLYLSLFFSLPRFQTLICKINKPSRLKVLVVHNLLTHISISACFYLSIYLSIYLSISACLYLAISACLYLSIYLYIYLYLILLLSIYLSIYISFCSYISIYISFCSNLSVYYNLSQPSHIYLSIYLSIYLSIYLYPSPTPPLSLSLSIYIYIYIYIYIYIYISFYCYLSVSLSAHIYLFLIQFVYIYSFCSYLSISLSAHIYLSIYLSIYLSIYLSIPVFSFLSISFYLYVRKYVCWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CAZ0</accession>
    <name>A0A812CAZ0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_34444</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001461">
        <property type="protein sequence ID" value="CAE1264953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CAZ0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1264953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="201" mass="23351" checksum="70E0B225E42652A1" modified="2021-09-29" version="1">MTDIDLGLKRCTEWHPQKAYPVRIETSLESSRPDGYFPLLSLPHFLCLSQSLLPSSLFLFLFLFLFFYFVFLLSLFVCSFLFVISLSLSLLITSHYLSLFSLYLKRSFLSSTLFLSASLSQSIFVLCILSFFSLSLYHSFSVHRSHLFVSLFLSFFLSFFLSFTAFPENFLFSLSLSLSLSIAYIQTHIRTYVYELSFKMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CB02</accession>
    <name>A0A812CB02_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_31573</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001300">
        <property type="protein sequence ID" value="CAE1259137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CB02"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="318"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="342"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="376"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1259137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="401" mass="47137" checksum="0D3EFE53ADF996F9" modified="2021-09-29" version="1">MSIDISVCSYLSIYLSIYLSIYQLLNSYLYIYDFILSIYLSITNHFFLSISSHFYLSIYLSIYLSICAPLSLYLSVYLSIYLSISMFISIYLSIYLSIYLSYLIFFIYLSIYLSIYLSIYHNESESNLSIYLSISVYIGCFYLSIYLSIYLSIYLNLFISIYLSIYLSIYLSIYPCYYVSIYIILSISIYLSIYLSIYLSIYGHVEVFHYSTFTPCFSLKMPSFLATLYHHLSIHLSSLFSKVSMHNLSIYLSIYLSIYLLCGFFFFTFYAVNIYLSIYLSIYLSRSDHINLSISTCSYLSIYLSIYLSIYPCSYLSIYLSIYLSIYLSIYLSIYLDLFVSIYLSIYLSIYLSRPVCIYLSIYLSIYLSISRPVRIYLSIYLSIYLSIYLSIYLSVHINCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CC72</accession>
    <name>A0A812CC72_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_31545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001299">
        <property type="protein sequence ID" value="CAE1259103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CC72"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1259103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="201" mass="24016" checksum="4FD3FFFA866FF0E1" modified="2021-09-29" version="1">MSFHTRLSIYLSIYLSIYLSIYLSISICFYLSFVTLLQVVHFYLCIFVDIYLSIYLSIYLSLTVHIYLSIYLSIYLSMLISIYLSIYLSIYLSIYLSLTVHIYLSIYLSIYQMICFYLRRFISIYLSIYLSIYLSIYQMISFSLRRFISIYVSLLISIYLSLTVHIYLSIFVDIYLSIYLSIYLSIYLSLTVHIYLSIYLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CH74</accession>
    <name>A0A812CH74_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Low molecular weight phosphotyrosine protein phosphatase</fullName>
            <shortName evidence="7">LMW-PTP</shortName>
            <shortName evidence="7">LMW-PTPase</shortName>
            <ecNumber evidence="7">3.1.3.2</ecNumber>
            <ecNumber evidence="7">3.1.3.48</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Low molecular weight cytosolic acid phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SPHA_36023</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Farmed</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the low molecular weight phosphotyrosine protein phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="7"/>
    <dbReference type="EC" id="3.1.3.48" evidence="7"/>
    <dbReference type="EMBL" id="CAHIKZ030001558">
        <property type="protein sequence ID" value="CAE1268166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CH74"/>
    <dbReference type="OrthoDB" id="3388at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004726">
        <property type="term" value="F:non-membrane spanning protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16343">
        <property type="entry name" value="LMWPTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000105">
        <property type="entry name" value="Low molecular weight phosphotyrosine protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050438">
        <property type="entry name" value="LMW_PTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023485">
        <property type="entry name" value="Ptyr_pPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036196">
        <property type="entry name" value="Ptyr_pPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002115">
        <property type="entry name" value="Tyr_Pase_low_mol_wt_mml"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017867">
        <property type="entry name" value="Tyr_phospatase_low_mol_wt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11717:SF7">
        <property type="entry name" value="LOW MOLECULAR WEIGHT PHOSPHOTYROSINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11717">
        <property type="entry name" value="LOW MOLECULAR WEIGHT PROTEIN TYROSINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01451">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00719">
        <property type="entry name" value="LMWPTPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00720">
        <property type="entry name" value="MAMMALPTPASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00226">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52788">
        <property type="entry name" value="Phosphotyrosine protein phosphatases I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphotyrosine protein phosphatase I" evidence="8">
        <location>
            <begin position="6"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="12"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="18"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR617867-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAE1268166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="156" mass="18298" checksum="6A1E361FFDA4C5CD" modified="2021-09-29" version="1">MESTKKRVLFICLGNICRSPMAHAIFEHLVKENGTSHKWEVDSAAIGDWHIGKQPDKRALKVLKENGIIFRHTVRQINPNDFEEFDYIFGMDHMNMRDLEEISGCKESKAKLEMLGKYDPENILVIPDPYYDTQAEFYPVYEQCYRCCKAFLETFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CKH8</accession>
    <name>A0A812CKH8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_35375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001520">
        <property type="protein sequence ID" value="CAE1266873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CKH8"/>
    <dbReference type="OrthoDB" id="9635126at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1266873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="173" mass="20276" checksum="539DA8DF58DE0063" modified="2021-09-29" version="1">MLICSYLSIYLSMLICSYLSIYLSMLICSYLSIYVNLFISIYLSMLICSYLSIYLSHSVHIYLSIYLILFISIYLSISFCSYLSIYLSIYPVPFSFNFSTYLFSTYLFPSLPVLPFSLIASFSFSIYLSIYLSIYLSIYLSIYLSLFITIYLSLFISIYLSIYLSIYLSIYQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CL17</accession>
    <name>A0A812CL17_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PPP4R2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SPHA_36819</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Farmed</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPP4R2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001619">
        <property type="protein sequence ID" value="CAE1269928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CL17"/>
    <dbReference type="OrthoDB" id="341898at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030289">
        <property type="term" value="C:protein phosphatase 4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015267">
        <property type="entry name" value="PPP4R2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16487">
        <property type="entry name" value="PPP4R2-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16487:SF0">
        <property type="entry name" value="PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09184">
        <property type="entry name" value="PPP4R2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="605"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="632"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="182"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="512"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="192"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="245"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="271"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="295"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="323"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="338"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="378"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="427"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="450"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="534"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAE1269928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="655" mass="71443" checksum="EAE23F8C12AB13CF" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CM53</accession>
    <name>A0A812CM53_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FBLN1_2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_39763</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001868">
        <property type="protein sequence ID" value="CAE1275959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CM53"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="299"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1275959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="331" mass="40610" checksum="98336A423ED5FC5A" modified="2021-09-29" version="1">MFHSLRFLDFFLHLIFFYFLPFLSCFPYLNFILFFLFYFILLFFILFSFFFSFPFFLFYLFNSVFYFILSFVFSFFIFIFIHVFILTFFHIFSFLRFSFFLSFFLLISLFFLSLFFFLSFLLLISLYLPFFFFLFSFFLSFFLSFDFIVSILFLLLTFSSILFLSFLLLISLVLFSFYFSFSSVFTFLSFFLSLSFFLSFFLSSVYHTINHTIISLPNFTFFLSFFLSFSHPPANISLNILLSFFHSFFLFSFFLSFFLSFDFIDSILFLLLTFFSYSFSFFLSFFLSFFLSFNFIFSLLYLLFFFFFSFYFIVSVLFYLLSIFLLNRHQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CNB2</accession>
    <name>A0A812CNB2_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Polypeptide N-acetylgalactosaminyltransferase</fullName>
            <ecNumber evidence="13">2.4.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Protein-UDP acetylgalactosaminyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SPHA_38609</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Farmed</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="13">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Golgi apparatus membrane</location>
            <topology evidence="2 13">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="13"/>
    <dbReference type="EMBL" id="CAHIKZ030001759">
        <property type="protein sequence ID" value="CAE1274055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CNB2"/>
    <dbReference type="OrthoDB" id="5988548at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005112">
        <property type="term" value="F:Notch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004653">
        <property type="term" value="F:polypeptide N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008593">
        <property type="term" value="P:regulation of Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23440">
        <property type="entry name" value="beta-trefoil_Ricin_GALNT11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02510">
        <property type="entry name" value="pp-GalNAc-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000053">
        <property type="entry name" value="Polypeptide N-acetylgalactosaminyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045885">
        <property type="entry name" value="GalNAc-T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675">
        <property type="entry name" value="N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675:SF63">
        <property type="entry name" value="POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13 15" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5 13" id="KW-0430">Lectin</keyword>
    <keyword evidence="12 13" id="KW-0464">Manganese</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="13 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Ricin B lectin" evidence="14">
        <location>
            <begin position="388"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAE1274055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="523" mass="60883" checksum="C7B3A2328B5FD32F" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CNZ9</accession>
    <name>A0A812CNZ9_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">WD repeat domain-containing protein 83</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Mitogen-activated protein kinase organizer 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SPHA_42353</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat MORG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002068">
        <property type="protein sequence ID" value="CAE1280476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CNZ9"/>
    <dbReference type="OrthoDB" id="71437at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000273">
        <property type="entry name" value="WD repeat domain-containing protein 83"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051980">
        <property type="entry name" value="WD_repeat_MORG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22842:SF3">
        <property type="entry name" value="WD REPEAT DOMAIN-CONTAINING PROTEIN 83"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22842">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="13"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="55"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="97"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00042222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAE1280476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="304" mass="34150" checksum="8243DE66B378C624" modified="2021-09-29" version="1">MSENILDKLIATIDCKQGAVRNVRFNNDGQYCLSCGSDKSIKLWNPHRQLMLKTYSGHGYEVLDAHSSGDNSQICSGGMDKSVILWDVASGKVLRKYRGHVGTVSCVKFNEESSVILSGSVDGTIRSWDCRSRKMDPIQILNEAKDSVTSVQVSDHEILSGSGDCRIRRYDLRIGRLICDYVGKTVTCVNFTRDDQCVLVSSLDGVVRLFDKQTGELLNEYKGHKNTDYKIDSCMNDKDDQVLSGSEDGHVYIWDLIEAKVKKKLYHETTRPIHSLSHHPKRTCLLTASGGNIYLWLSPYETDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CP86</accession>
    <name>A0A812CP86_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_38116</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001724">
        <property type="protein sequence ID" value="CAE1273361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CP86"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1273361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="265" mass="31463" checksum="83C8A304F133E4E4" modified="2021-09-29" version="1">MRSFVQSHEHLSIYLISSLSIYLSIYLIQNLSIYLSFIHSFYLSIYLSIYLSIYLLFFIIYLSISHLVHVHYLYSISIFYLSFIQFIIYLSIYLSSLSIYLSFGSLSIFHSVHYLSIYLSIYLSIYLSFSSLSIYLSIYYSIHYLSIYLAISHLVHYLSFIQYIYLSIYLSSIYLSFSSLSLSIYLLFNSLSIYLSCYLSFGSSIFHSDYLICIYLSFIQFIIYLSFYLSIYLSILFILSIYLAISHLVQMHYLSIYNRYLSIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CRN7</accession>
    <name>A0A812CRN7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Monocarboxylate transporter 14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SPHA_38819</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001780">
        <property type="protein sequence ID" value="CAE1274350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CRN7"/>
    <dbReference type="OrthoDB" id="410267at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF260">
        <property type="entry name" value="MFS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="135"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="191"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="437"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="468"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="42"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="501"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAE1274350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="529" mass="58003" checksum="0F3D65F104A7BFBF" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CTI0</accession>
    <name>A0A812CTI0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CIB1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SPHA_40729</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001935">
        <property type="protein sequence ID" value="CAE1277596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CTI0"/>
    <dbReference type="OrthoDB" id="114727at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000079">
        <property type="entry name" value="Calcium and integrin-binding family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051433">
        <property type="entry name" value="CIBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45791:SF1">
        <property type="entry name" value="CALCIUM AND INTEGRIN BINDING FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45791">
        <property type="entry name" value="CALCIUM AND INTEGRIN BINDING FAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="113"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAE1277596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="204" mass="24268" checksum="969CD2869354E45D" modified="2021-09-29" version="1">MSDIPRESNISKCFFISLFFSFYLVLCREYPEHTFLKRREIKLLFKEFKNLDYDAVSMNRNCELPMEVIQNSSRLKVNPFRKRICQVFSHNGTGAMTFIDFLDMISVFSAKSPLQIKLEYAFRIYDFDNDNVIQMNDIKKTMKCLSDAQGLHEEDQLTEEQMELLIEKVIEEASIDTERGISFEEFCTVLKKIPYFLEYFQMRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CY43</accession>
    <name>A0A812CY43_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_43982</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002225">
        <property type="protein sequence ID" value="CAE1283313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CY43"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032885583" evidence="2">
        <location>
            <begin position="20"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1283313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="155" mass="17464" checksum="E7C633D8F373BC63" modified="2021-09-29" version="1">MLTKHSSLSLSLSLSLSLSQLSYDWEAICMSKFGKSFHQRAEVAGRRPAPLTPSFSYWYLIPTPLNGPIKLLSATSLVVSVKKKKPAVVAIHRCYCTLLTSSFGFHFNQMPKWILALSSREVLYSQNEKTSIFSFVFGMSFNLSTTFFVLVFSFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CY81</accession>
    <name>A0A812CY81_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_42341</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002068">
        <property type="protein sequence ID" value="CAE1280507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CY81"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032977876" evidence="2">
        <location>
            <begin position="19"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="307"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1280507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="342" mass="38750" checksum="D3BD5AFF732CB426" modified="2021-09-29" version="1">MSLSFFVYILLLLHLLYSSFTSTLSLYPPSSSRLYSSFSSSYLSIFFPLFLSICFLLLLPLYNPSSLSFHILPLPPPSLYILLPLSVYIHPLPPYSPYSFLFSFLYASFSSYLYILLPLFSSIFFLLFRLLSLYPPSSFPVYLPPSPTLPASLPSSFLLYSSSSSYSSSYISLLSSLLYSSSSSSPSSYPYVLLPLFPSKQRFPFSFSCLHIHYSRLNFPPPPSIFMSLLHASSPPSLYPPSSFPFFISLLLSPPVFFFDFFVFNLELFLLLLLLLLLPLYSPFYQFKVSSSVILAPLLHTLSPADFFLISCFRHAPIFFSILSIGFSFSLFLIVTMTSHIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D030</accession>
    <name>A0A812D030_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_44679</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002283">
        <property type="protein sequence ID" value="CAE1284312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D030"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1284312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="178" mass="20941" checksum="E1A19C2AA4A416E7" modified="2021-09-29" version="1">MPTLFSSHYLFNIFFLFILYFSYSPFLDPYSPFLGPYSPFLDPYSPFLDPYSPFIRPYSPFHSPFFLVSFPFILFRSITLLSPVWYHFLPALSRPHFSSSFFVMYFNCLHASLRKDSRAAFQLKVTNVNILTFSAFMINRVVGSTIYSRRQRLQLSRLPPHPDAYGGFQMWNKAKSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D1K5</accession>
    <name>A0A812D1K5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_45863</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002390">
        <property type="protein sequence ID" value="CAE1286180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D1K5"/>
    <dbReference type="OrthoDB" id="6117374at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327">
        <property type="entry name" value="ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327:SF3">
        <property type="entry name" value="RNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1286180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="184" mass="20970" checksum="4F1110BF3BD32426" modified="2021-09-29" version="1">MSDTVLRKLWMDKLSPQTSQILVSLPDDLDLQRLAEIADKIYENKPPGNASATPLQPIVSSVRDSQELLKIKDCIAELTSQLQALQTAMHQQNRTPNNFTSRPRPSHHTRRRSRSTSRSRPIFNTCWYHFKYGQQARHCTKPCNFDINAAKDNNTQQSGKRLSRQQVETFAAGGCQKSSLLHPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D2K2</accession>
    <name>A0A812D2K2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_47581</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002588">
        <property type="protein sequence ID" value="CAE1289303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D2K2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1289303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="333" mass="41778" checksum="BC38173A95E4447E" modified="2021-09-29" version="1">MLFCFFFFFLSFFSFFQSFFKLFFFFIKFFFIYLPFFFFFFLLFFFYFLLIYFLKNFFLAISSSFIFFSSFFFFVAFFISSFFFRSSLPLFLIPLFIYYYFSFTPFFSFLPYFFFLLFLSYFLPFSFILWVFHSLHLFYFLGLILYNSSGFFFFLSFSNGFLFFFFFYLISFLSLLIFSILSFFKKFLLFSFLYFFSFLNLSFKIFFFLFFFFFFFLILLFFFHCNMFLTLKTIIFFFFFFSQIILIFLSFFPYLPSFLKLILLFEFVSSFYSFLFFSFFFLSFFLLHSPFRLYFFRLFFQFPSPFSFPSPSSTIPYVNPSFLSFFHHPFLFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D3C6</accession>
    <name>A0A812D3C6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_45329</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002334">
        <property type="protein sequence ID" value="CAE1285235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D3C6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="315"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1285235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="334" mass="37902" checksum="20F8E041D3601FCE" modified="2021-09-29" version="1">MLKSFFSSSFAISLLFSLFFFIYLACYLFISIYLSQFVHIYLSITVCSYLSIYLSIYLSIIGCSYLSIYLSIYLSIYHSLFISIYLSITVCSYLSIYLSIYLSITVCSYLSIYLSIYLSIYLSIYLSIYLSQSVHIYLSDNICRYILSFILLSYFLIFSLSPSFFFSVSPLSPLFLSLSLSLSLSLSLSLSLSLCICLSISVHINFHFSIFPYLFLSFFFLLFLVYLFHHLPTFIYPFFFCHLLLLTILSSSSSSSSSSSSSSSSSSSSSSFHLSLSLSLSLLSLSFFLSFFLLLNTISLSLSLSLSLSLSLNPLYIYITFCIGFALLLLILWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D4B3</accession>
    <name>A0A812D4B3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_46847</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002501">
        <property type="protein sequence ID" value="CAE1287905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D4B3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
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            <end position="43"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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        <location>
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            <end position="113"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1287905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="235" mass="27859" checksum="2AEEB9E9148BE60E" modified="2021-09-29" version="1">MSLSLSLLHFSRSFSCSFSNLLSSYPPFPLSLSLTFTIFHYFSLSLSLSLSLSTYSFLSLCFSFSILLLNLYYHFSFLSVSLFLSSFFSIHLLIFSFFFFLSFFLFPSFLSFFEESIVKFTFSFIFYFTISLSIFLSQILFRRCYLFFSFHFLLSFFLSFFLSFFLSLTFIYCLHFLSFCFLLSFILSLSILLSALSFLSFPAFLYFFVSFILSFINILSSVVFRYFFYFSLFIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D598</accession>
    <name>A0A812D598_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_48937</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002767">
        <property type="protein sequence ID" value="CAE1291816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D598"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="221"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="252"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="367"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="402"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="436"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="633"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="639"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1291816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="671" mass="77784" checksum="687DBC8FD7632144" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D962</accession>
    <name>A0A812D962_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SPHA_47508</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002578">
        <property type="protein sequence ID" value="CAE1289127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D962"/>
    <dbReference type="OrthoDB" id="411372at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045124">
        <property type="entry name" value="Su(sable)-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054361">
        <property type="entry name" value="Znf-CCCH_ZC3H4/6/8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13119:SF12">
        <property type="entry name" value="PROTEIN SUPPRESSOR OF SABLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13119">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22623">
        <property type="entry name" value="zf-CCCH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="8">
        <location>
            <begin position="322"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="8">
        <location>
            <begin position="352"/>
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        </location>
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    <feature type="domain" description="C3H1-type" evidence="8">
        <location>
            <begin position="380"/>
            <end position="403"/>
        </location>
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        <location>
            <begin position="322"/>
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        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="6">
        <location>
            <begin position="352"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="6">
        <location>
            <begin position="380"/>
            <end position="403"/>
        </location>
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        <location>
            <begin position="1"/>
            <end position="269"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="7">
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="896"/>
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        </location>
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        <location>
            <begin position="1"/>
            <end position="22"/>
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    </feature>
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        <location>
            <begin position="26"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="40"/>
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        <location>
            <begin position="87"/>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
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            <begin position="105"/>
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            <begin position="162"/>
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    <feature type="compositionally biased region" description="Basic residues" evidence="7">
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            <begin position="172"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="208"/>
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        </location>
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    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="296"/>
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        <location>
            <begin position="448"/>
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        <location>
            <begin position="524"/>
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        <location>
            <begin position="576"/>
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        <location>
            <begin position="615"/>
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        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="683"/>
            <end position="694"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="704"/>
            <end position="748"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="760"/>
            <end position="771"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
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        <location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
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        <location>
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1062"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
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        <location>
            <begin position="1171"/>
            <end position="1188"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAE1289127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1246" mass="137811" checksum="A6C548AE1D91E23A" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D9L4</accession>
    <name>A0A812D9L4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_51884</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
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            <taxon>Acanthosepion</taxon>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="CAE1297244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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            <begin position="145"/>
            <end position="167"/>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAE1297244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="197" mass="22783" checksum="94DB01C7FC449C5C" modified="2021-09-29" version="1">MVLLFYIFSLPDSCCILYDVNCGSVAIPTGNYYQTGCGESLSRWARRHEISSAVLITEQVSILLSIYLSIYLESLFTKDLSILFTLVSIMPVHILSLHPSQRLFITINLSIYLSKSIYLIRDARHLSMSVHIISIYLWHSIHLSIYLYIYTIYLSIYLLSNLVQVIYKKTGSRNLFSRRLPAYLLRNVLCFWLTCSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DFP1</accession>
    <name>A0A812DFP1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">SPHA_53271</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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            <taxon>Decapodiformes</taxon>
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            <taxon>Sepiidae</taxon>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000597762">
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        <location>
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        </location>
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        </location>
    </feature>
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            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1299516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="174" mass="18928" checksum="061732C4A796AD34" modified="2021-09-29" version="1">MSLSFSLSLCIILPSPLLNLILSPFPSLSLSPSLSASLYHSYSITPTLSFSLSFSVPVYLSRSLLSSLSLYLFHYLALALFFFSLCFSLIPSLSPYLSLILSLIPSLSPYLSLSHSLSLSLSLSLSLSLSLNTVNVNAFIIFHLRLPILPPGPNQDLFISQAPLFLFPPTASLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DHS4</accession>
    <name>A0A812DHS4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_53220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Spiralia</taxon>
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            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
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    <reference evidence="2" key="1">
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            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003369">
        <property type="protein sequence ID" value="CAE1299391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DHS4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <location>
            <begin position="21"/>
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    </feature>
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        <location>
            <begin position="63"/>
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    </feature>
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            <begin position="120"/>
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        </location>
    </feature>
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        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
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        <location>
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            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1299391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="280" mass="32418" checksum="3EA2F495A6C0DD4C" modified="2021-09-29" version="1">MTAKSISGVASRLLSRNSLPFCCLSFSSLLFRFYPLTSCGFLSNLSLAKNSLIHSLIRSLVHKFLVCLSLSFFSLLRPLFIVVKFSILFLPFSRIFSSKFVFFLLFSFFSLAVYTLYTLYVYFFFLLILLHYIISFPIELSPAFFFKIFSFLHLFLPPLLLFLLFLFSFNIQNYVLHPISTPEVFFFIFLSLKKIFSFILFFSSHNTTLSSCLTHFITSSNFSFFIPHFCLISKFLSHLFFFLPLPPFFLDDLCGSLTAFFLCMTDSLCLCLCLSLSLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DI87</accession>
    <name>A0A812DI87_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_52265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003228">
        <property type="protein sequence ID" value="CAE1297817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DI87"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="333"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="375"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="411"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1297817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="456" mass="53834" checksum="DA9C4CD42F4B0B02" modified="2021-09-29" version="1">MTILNRVLHNRRIERGIETLVSISLSLSLSLSFFIYVSIYLRPYLYRCVFKFKFACIYLSIYLSIYLSMYLSIYLILICMPLLTSIYLSIYLSIYLSIYHASIYKHKCAQRNNNDSRRICCVEYKPSIYLSIYLSIYLSIYLRHIFFYVYLNSNLCAPGHIYLSIYLSIYLSIYLSITHLYTNIDMLREITSLFPYIYKEVLKLSQPGPLAEVYLSIYLSIYLSNSLADIFFYSGPLAEVNLSIYLSIYLSIYLSIYLSAYSYTNQLPEIYPLSLYTIIYLSIYLSIYLSIYLFIYPLDFLFGLFSLFFFFFFLSFLFPFYNLSFSFIRPFPFLLSSSVFIFESVVVDYTIPIIYPCCFPRFENKSDTNRIEILFSIYLSIYLSIYLSIYLSISLYIYLCIYLSQCLSVHIYLFILLIYLSLSMSFTLFFSPLSLCLSQAELIHRILSRARTPPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DLM2</accession>
    <name>A0A812DLM2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_55418</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003692">
        <property type="protein sequence ID" value="CAE1303151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DLM2"/>
    <dbReference type="OrthoDB" id="6381149at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1303151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="240" mass="27327" checksum="A01741953ACE6E6F" modified="2021-09-29" version="1">MIHQFCEKVDEYQKCVAEEEKEQITIELMQGMCEYGFEAVYKNITCLSKVITELKSTCISKRDACAISEEWFQCSLMVTQNICGEYLGYVMADLQQLYCQIFQVMTAEEPLEYDLIYAEDESEQTVDQFSIKNPIETTRRLSTKKSIKSTTPHKTNSPIITKRPHSTKKPGTTKQPHSTKKPGTTKRPHSTKKPGTTKRPHSTKKPSTTKRPHSTKMPSTTKRLATTTGQVTTTNSVRIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DNL2</accession>
    <name>A0A812DNL2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">CSRP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SPHA_59878</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004150">
        <property type="protein sequence ID" value="CAE1307902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DNL2"/>
    <dbReference type="OrthoDB" id="1679758at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030018">
        <property type="term" value="C:Z disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042805">
        <property type="term" value="F:actinin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008307">
        <property type="term" value="F:structural constituent of muscle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060537">
        <property type="term" value="P:muscle tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045214">
        <property type="term" value="P:sarcomere organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09404">
        <property type="entry name" value="LIM1_MLP84B_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09326">
        <property type="entry name" value="LIM_CRP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000001">
        <property type="entry name" value="Cysteine and glycine-rich protein 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24215:SF35">
        <property type="entry name" value="MUSCLE LIM PROTEIN MLP84B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24215">
        <property type="entry name" value="RHO-GTPASE-ACTIVATING PROTEIN LRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="9">
        <location>
            <begin position="9"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="9">
        <location>
            <begin position="112"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="97"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAE1307902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="188" mass="20083" checksum="F127DC1D69A64143" modified="2021-09-29" version="1">MPFKPVEQAKCPKCSRSVYAAEERLAGGYKFHKSCFKCDLCNKMLESTNVAEHESKLYCKQCHGRKYGPKGYGFGGGAGALSMDTGAQFGNKESEMSNKPTSGSSGDAGTGPKCPRCGKTVFDAERAIGSTVPWHKACFRCKQCSKALDSTNQNAHEGEIYCKTCYGKNFGPSGYGFGSGAGTLSSDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DPN8</accession>
    <name>A0A812DPN8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_59873</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004150">
        <property type="protein sequence ID" value="CAE1307897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DPN8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1307897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="384" mass="43103" checksum="35FB86C718642E73" modified="2021-09-29" version="1">MAKKKKVKCKRKTTKENSAKTFDNPIKKHIKQLNEMDNSLPTPGTSSEKYPEQKISLITQSRVTNAPIKEIAVEMLSNLQQKQILFNRNIRKERYNELQRLLMQSLLSSSPCSSVEKAKPAAMISAKRALIKTTSLASKGSLKTDSEKETGIDEKQLNLSGFNDAKSLLIQNDILLKLDENPQQKSASTGKSPESMDIVQNLDHSRGQHSALDSVNVPTPCENQPIDHAGDSAPLNTNKLKLMTCKKFFHCQQTEQNKHHVSSCIIVANEPLFRETCKSVPGFSGDCVDSVESTIKKKQIYQTQDSLDFLEYLDQSNTTDVSSSFWDSHNKFYTWNKTAFKDTSSDSENSPLWVPLSNLPPPPTKPCLDAIPSPPEKLYPRKLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DQP6</accession>
    <name>A0A812DQP6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_58731</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004034">
        <property type="protein sequence ID" value="CAE1306456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DQP6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1306456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="196" mass="22781" checksum="0A9D6B66DA14C05F" modified="2021-09-29" version="1">MTPPDIYLSIYLSIYLSIYLSIYLSPSSLNLSLSQSLSLPLSLSLYIYIYIYTGLVSLFCISFLNHLRFFMSSYILPLLCFFLHMYFCLSSSSSSLNSHRPPCFLSFFLVFSIYLSIYLSIYLSISKKIERDTENHIRVRLTGKCNNNNNNNIYLSIYLSIYLSIYQQKGKCNNNNNNNIYLSIYLSIYLCKLSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DR48</accession>
    <name>A0A812DR48_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="13">PSMC6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SPHA_59819</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004146">
        <property type="protein sequence ID" value="CAE1307766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DR48"/>
    <dbReference type="OrthoDB" id="1937997at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000008">
        <property type="entry name" value="26S protease regulatory subunit 10B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000027">
        <property type="entry name" value="26S protease regulatory subunit 10B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000034">
        <property type="entry name" value="26S protease regulatory subunit 10B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006925">
        <property type="entry name" value="Vps16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04840">
        <property type="entry name" value="Vps16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00830">
        <property type="entry name" value="ENDOLAPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="897"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="965"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="987"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1014"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1041"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1125"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1159"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="12">
        <location>
            <begin position="171"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="473"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="506"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="14"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="473"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="507"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="568"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAE1307766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1182" mass="134209" checksum="F8F02E44D7119CDC" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DSC7</accession>
    <name>A0A812DSC7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_58252</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003973">
        <property type="protein sequence ID" value="CAE1305892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DSC7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1305892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="264" mass="30088" checksum="D09E05D762529B07" modified="2021-09-29" version="1">MNSLFPFRLLTLPSLYLLSLSLSLSIYLSISLNSQFFWTLVDSMSFGIPFLFLIFFAQNLQVSFPLTHFFQFMLLPFYLSSVLSLFLFVLLPFYPSSFLSFFRFILLPFCPSSVLSVISFVLLPFCPSSVLSVISFVLLPFFSSSILSFFRFVLLPFYPSSFFVLLPFYPSSFLSFFRFILLPFCPSSVLSVISFVLPFCPSSVLSVISFVLLPFFRLPFCPSSVFPSSILSSFDFARLLFGPSSVLSFFHFPPKYDNSTPFSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DSF4</accession>
    <name>A0A812DSF4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_61373</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004332">
        <property type="protein sequence ID" value="CAE1309676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DSF4"/>
    <dbReference type="OrthoDB" id="10062692at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1309676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="210" mass="24724" checksum="9DBD8F72512DC9E0" modified="2021-09-29" version="1">MLLAGEELRRTTPTRSEEQPGEYGRTRHQRFRETPYSPPQHHRIPSHPRQHVFPTLPAPPDTKDEFYNKLETTISINSFFRTKTQHKVSWRHPCSKHWHQLDLILVRRAAIKNVLHTRTYHSADCDTDHSLVCCKIKLQHKRFHRGKNQGKPRIDVSKMSQPDFVQQFVKRYENELATSRTGHSATEKWATLWDTMHRTALVTFGRTTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DX36</accession>
    <name>A0A812DX36_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SLC4A10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SPHA_64044</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004609">
        <property type="protein sequence ID" value="CAE1312845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DX36"/>
    <dbReference type="OrthoDB" id="1735926at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008510">
        <property type="term" value="F:sodium:bicarbonate symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005452">
        <property type="term" value="F:solute:inorganic anion antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011531">
        <property type="entry name" value="HCO3_transpt-like_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003020">
        <property type="entry name" value="HCO3_transpt_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453">
        <property type="entry name" value="ANION EXCHANGE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453:SF36">
        <property type="entry name" value="ANION EXCHANGE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00955">
        <property type="entry name" value="HCO3_cotransp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Bicarbonate transporter-like transmembrane" evidence="5">
        <location>
            <begin position="2"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAE1312845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="183" mass="20392" checksum="F7C897FB6A7900E7" modified="2021-09-29" version="1">MLIRYVTRFTEETFACLIALIFIFEAHQKMFEINSNYPVNRQGSRSFRCMTTTLNQVEQRPIDGEDVNETNTNVSGDGAGQGLFVTSQISASESQSYPHIEPAVLWKEAAREVMVTNSTTLLQLNGTEGDLVPTDCSNCVEEGSYVPDVFLLSVLLFLGTYIVARGIERFRTSGFFPQIVSPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DZD7</accession>
    <name>A0A812DZD7_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Helitron helicase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_61448</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004347">
        <property type="protein sequence ID" value="CAE1309770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DZD7"/>
    <dbReference type="OrthoDB" id="6151730at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492:SF57">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1309770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="241" mass="27423" checksum="A14CA2C87CD187F1" modified="2021-09-29" version="1">MHTIEWQKRGLPHAHILIWLCDKIEATEIDHLISNEIPDPWADPELYEIVTTNMIHGPCGSHYNYTSCHNKDGKCTRQYPRDFVSEAITGSDGYPLYRRRSPAEGGFTAVVKGHQVGNRWVVPYCPLLTKAFNAHINVEYCHSVRSIKYVCTYINKGTDAAMFGIRQDGSVDEIQDFLAGRVISSTEGPWHIFSFLIHERFPARKRRTSLFFCGYSNGCGCAYQRHNAYTVLQTLSTGRVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E0H0</accession>
    <name>A0A812E0H0_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cytochrome oxidase subunit I profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_64069</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004613">
        <property type="protein sequence ID" value="CAE1312894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E0H0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023616">
        <property type="entry name" value="Cyt_c_oxase-like_su1_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50855">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="298"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="342"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="367"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="415"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="461"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="493"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="519"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="553"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="582"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="621"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="647"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="675"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="712"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="745"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="771"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome oxidase subunit I profile" evidence="2">
        <location>
            <begin position="55"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1312894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="806" mass="97012" checksum="9331EC4EDB3A6367" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E1Z4</accession>
    <name>A0A812E1Z4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_66824</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004820">
        <property type="protein sequence ID" value="CAE1315980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E1Z4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1315980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="255" mass="30623" checksum="CA44DC1C68939947" modified="2021-09-29" version="1">MIPYKQRCCFCCFFLLLSSSSSSCSFFFLLLPSSFFFLLSSASFFLLLSSPSSSFFFFFLLLPSFFFFLLLSSFFFFLLFPSFFFFLLLLLPSFPSSFFFFSSTSSSFFLLFPSFFFFLLSSSFFTFFFFLLLSSFSFFLLLLPSSLFFFLLFPSFFFFFLLLYSSPFFFFFFSLLLLLSSFFFFLLLPSFFSFLFLLFPFFLLLPSFFFFLLSSSSFFLLLSSPSSSFFFFLLFPSFFFFFFFFFFFFFSTFVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E270</accession>
    <name>A0A812E270_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">XRCC4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SPHA_64670</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the XRCC4-XLF family. XRCC4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004657">
        <property type="protein sequence ID" value="CAE1313563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E270"/>
    <dbReference type="OrthoDB" id="8064436at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032807">
        <property type="term" value="C:DNA ligase IV complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005958">
        <property type="term" value="C:DNA-dependent protein kinase-DNA ligase 4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010165">
        <property type="term" value="P:response to X-ray"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22283">
        <property type="entry name" value="HD_XRCC4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.210.10">
        <property type="entry name" value="DNA double-strand break repair and VJ recombination XRCC4, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010585">
        <property type="entry name" value="DNA_repair_prot_XRCC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014751">
        <property type="entry name" value="XRCC4-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038051">
        <property type="entry name" value="XRCC4-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053962">
        <property type="entry name" value="XRCC4_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053961">
        <property type="entry name" value="XRCC4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009089">
        <property type="entry name" value="XRCC4_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28559">
        <property type="entry name" value="DNA REPAIR PROTEIN XRCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28559:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN XRCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06632">
        <property type="entry name" value="XRCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21924">
        <property type="entry name" value="XRCC4_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58022">
        <property type="entry name" value="XRCC4, C-terminal oligomerization domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50809">
        <property type="entry name" value="XRCC4, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XRCC4 N-terminal" evidence="8">
        <location>
            <begin position="92"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="XRCC4 coiled-coil" evidence="9">
        <location>
            <begin position="201"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="277"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="277"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="289"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="347"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="366"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF06632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAE1313563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="404" mass="45952" checksum="4C66280726B41E99" modified="2021-09-29" version="1">MVSPQSCLVDGILHHVKDLCSHCSVTTLEEDSNSTTTSSEILLHDSRDMELDVRKRFHSAQLSTFLFCKITGAYGLSVFSLTDEINKRYKSFCHGEYMKDNGEDGFHLILCDGNDSWEGDISGNDIHDMCSLSSIDYKDYVEMTVQALTGKSGPNISFQYQIDHSSQEYVQFHWKKHIVSDDVKFRLGSTKLSQSDDSNKTIQKIFDHCIEKISNLNHKITTTQMDNERLSQERANALKTLNNCVSAKEKLEEDLYSKFLMVLNSKKKEIENLRQKVEEQKQDHTEADNSNEELTDDENSSSYSAETEKDGSDTPNTVGGKKAKWNDSLVFTDDSPDEDMDNLSRIQKPEIKQDKKSNASTSKVSSEYDKSKKIVKMKEEKHKRSFGKKSASDLTDTNDLLDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E2Q4</accession>
    <name>A0A812E2Q4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_65382</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004722">
        <property type="protein sequence ID" value="CAE1314401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E2Q4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1314401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="197" mass="22330" checksum="F6133D0EF7621CEC" modified="2021-09-29" version="1">MEDIFLSFIAIYLSRSAHIYLSIYLCSTQICLSMSLHIFLFLSSLSLSLSLSLSSHIYLSLHLSIWIDSHLSIHVNSHLSICRLSLSIYVILSKSIYLFIYLSVCLSIDLSFILFITLYLSISLSKAIFLFISVCPKLFMSACSYLSIYLSFILFISLYLSVSPNYLSIYLSLSKAIYVSLSIYLSIYLSIYCILGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E427</accession>
    <name>A0A812E427_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BRD4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SPHA_67937</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004929">
        <property type="protein sequence ID" value="CAE1317377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E427"/>
    <dbReference type="OrthoDB" id="21449at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05497">
        <property type="entry name" value="Bromo_Brdt_I_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05498">
        <property type="entry name" value="Bromo_Brdt_II_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.10:FF:000003">
        <property type="entry name" value="Bromodomain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.220:FF:000001">
        <property type="entry name" value="bromodomain-containing protein 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.10:FF:000002">
        <property type="entry name" value="Bromodomain-containing protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031354">
        <property type="entry name" value="BRD4_CDT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043508">
        <property type="entry name" value="Bromo_Brdt_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043509">
        <property type="entry name" value="Bromo_Brdt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050935">
        <property type="entry name" value="Bromo_chromatin_reader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027353">
        <property type="entry name" value="NET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038336">
        <property type="entry name" value="NET_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22880:SF225">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN BET-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22880">
        <property type="entry name" value="FALZ-RELATED BROMODOMAIN-CONTAINING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17035">
        <property type="entry name" value="BET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17105">
        <property type="entry name" value="BRD4_CDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51525">
        <property type="entry name" value="NET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Bromo" evidence="5">
        <location>
            <begin position="76"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="5">
        <location>
            <begin position="408"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="NET" evidence="6">
        <location>
            <begin position="565"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="170"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="258"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="323"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="360"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="496"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="640"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1026"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1094"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="11"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="176"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="225"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="290"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="500"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="512"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="640"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="656"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="706"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="733"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="812"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="858"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="948"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1094"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1114"/>
            <end position="1126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAE1317377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1134" mass="125360" checksum="8339264B238FA561" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E681</accession>
    <name>A0A812E681_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_68838</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005028">
        <property type="protein sequence ID" value="CAE1318382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E681"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="315"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="352"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="382"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="421"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="449"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="517"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="569"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="593"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="628"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="661"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="684"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1318382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="708" mass="87591" checksum="15E382E4070F11B5" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E8Q1</accession>
    <name>A0A812E8Q1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_68581</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004998">
        <property type="protein sequence ID" value="CAE1318081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E8Q1"/>
    <dbReference type="OrthoDB" id="10018757at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052709">
        <property type="entry name" value="Transposase-MT_Hybrid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46060">
        <property type="entry name" value="MARINER MOS1 TRANSPOSASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46060:SF1">
        <property type="entry name" value="MARINER MOS1 TRANSPOSASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1318081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="173" mass="19896" checksum="1B8494B629EB0BE4" modified="2021-09-29" version="1">MTAELKEHRLEVSQDHRQPVADDLFFMPRIISGDESWVYGYGPETKQQSTQWKSPSSPRPKKTRQSRSTVKSMRIVFSTSVVLCIENSSPRSRPSIESRSVKATGSMEREELDSSRRKSILSQSSPHSPSTNIYLSIYLSIYLSIYLSIYLSISERRRHADEKVLSIYLSIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E9T5</accession>
    <name>A0A812E9T5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_70911</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005193">
        <property type="protein sequence ID" value="CAE1320694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E9T5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <begin position="146"/>
            <end position="174"/>
        </location>
    </feature>
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        <location>
            <begin position="180"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1320694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="324" mass="36967" checksum="3BF4F07928F817DD" modified="2021-09-29" version="1">MEEEDQIVEKSPDETGIEDVKPSQVKSLDNDEITEASKNSGRSSDNDEITEASKNSGRSSGRLMWIKTFFHERGNPCDFPPILVGQRSGWSRWPGAPSWVLGHRWCGVLSCNLVFIHVHVVLGFVSHSAGRRNVDLSPMSIGSSGFPCFSVYHCACLLSIFLSIVVSVFIYVYFSAFLSLVGFICQPIYLHINICFSIYHCIYLYNDKITEASKNSGRSSGRLMWIKTVLCKPSVIMITTILVFEGSYRIAPYLKIDHRYTGRLIWIKTLLREPRLLTTAQIAFLGCSYRIASCLNIDKKYVDALVFLFEHYFQFPFREFFFHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EBS8</accession>
    <name>A0A812EBS8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_69416</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005074">
        <property type="protein sequence ID" value="CAE1318972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EBS8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1318972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="216" mass="25650" checksum="4708F7682415B9C6" modified="2021-09-29" version="1">MAVLSGDCVYFLAVNPSLSIYLSIYDSDSIYLSIYLSIYLSIYLSIYIYIYIYYLSIYLSIYLSIHLSIYLSNQLTVGGVFNLDSVFLSFFNYSFFLFFSLFLFIFSFLSLFLFPFFYLSFLSFFHSFISLHFTSFSFFHSFLSLSYISFSSFLSFFLSFFLSFRFLPLFSFFTIRSSFLSFFFLSIHFFLYFNHAKTDTHLLSCTPEKNDILKFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EEE8</accession>
    <name>A0A812EEE8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_73700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005385">
        <property type="protein sequence ID" value="CAE1323877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EEE8"/>
    <dbReference type="OrthoDB" id="300855at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="158"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1323877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="240" mass="28270" checksum="7506133FF65F2C11" modified="2021-09-29" version="1">MRGVRWDGAQVRQVAASGESMYDDAFTIHMVEMENEDEFNFVAGMVPYLLNLIKDVIKDFIFFLSFFLSFFLSFHLFFFLSFFLATYSSFFLSFFLSFFLSFLPLILLSFFLSFFLATYSSFFLSFLPLILLSFFLSFFLATYSSFFLSFFLATYSSFFLSFFLATYSSFFLSLSFSFFFLSEYFFFLKEKRRASSEFQKNPCRINSNGRTTIVYVSGRNHRQESTETNAESQGKFKALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EHL3</accession>
    <name>A0A812EHL3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_73866</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005398">
        <property type="protein sequence ID" value="CAE1324077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EHL3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1324077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="309" mass="37749" checksum="BA8354754F24DCD9" modified="2021-09-29" version="1">MSSTKTFLPSFIHSFYSYLSIYLSIYLSIYLSIYLNFSICQCWTHTLRFFFFCFFFFFFFFLFFFFLFFSFFLFLFYLFLFSFSFFICFFFLFFFFFFICFFFLFSFFFFLFLFSFSFFLFSFSFLSIYLSNPSLLKSIYLSIYLSIYLSIYLSIYLLTSAVFIIVLLFLPSFLPSFLPIYLSIYLSIYLSIYLYIYIYIYIYICQSIYLSHLSVIYLSIYLSIYLSIYLSLSVFYLSVYEFVNFYLSIYLSIYLSIYLSIYLSMCVCVCLSISSVRYLSIYLSIYEFVNFYLSIYLSIYLSIYLSIIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EKT5</accession>
    <name>A0A812EKT5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_75463</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005459">
        <property type="protein sequence ID" value="CAE1325850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EKT5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="293"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1325850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="318" mass="37834" checksum="078069371AFD9569" modified="2021-09-29" version="1">MSLRPCTFINFAHCPFSRDMTSAMTSKRSPFLPVKFMSVLRTSTTSVSFFPSFFFYFHLSSYLHSCLSFFHSFHCLIFIVISFLFISFPLSFFLSFFLSFLYFLFILRFSFSLFLFSWLSFLSFFMFFLSPSYSFFLYVFLSSIPFFMSFSPFFLSSVLSFFLSFFLSLFIYLFIFPFFMSFSLFFLSSFLSLCLSIFFSLFLFSFLMFIFLSYFLCFHLFLLFSFSNYFSFLSIFTLSFTLPFLHSLSLIFSFFFFFFSSFFLPFFIRPFVLSFLLPFLLLLSSYLSLFLTIFLLLSLSSLSLSLSLSIYLSIYLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EMG1</accession>
    <name>A0A812EMG1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="16">DNAH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SPHA_78697</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005548">
        <property type="protein sequence ID" value="CAE1329167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5593012at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2620:FF:000001">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.180.20:FF:000004">
        <property type="entry name" value="Dynein axonemal heavy chain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1120:FF:000007">
        <property type="entry name" value="Dynein heavy chain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000063">
        <property type="entry name" value="dynein heavy chain 6, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.100">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.20">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042222">
        <property type="entry name" value="Dynein_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042228">
        <property type="entry name" value="Dynein_linker_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878:SF68">
        <property type="entry name" value="DYNEIN HEAVY CHAIN 6, AXONEMAL-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878">
        <property type="entry name" value="DYNEIN HEAVY CHAIN 6, AXONEMAL-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08393">
        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0243">Dynein</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Dynein heavy chain linker" evidence="14">
        <location>
            <begin position="679"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain linker" evidence="14">
        <location>
            <begin position="870"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain hydrolytic ATP-binding dynein motor region" evidence="15">
        <location>
            <begin position="1187"/>
            <end position="1356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="29"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="79"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="616"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF12774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAE1329167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1361" mass="156206" checksum="DC44C24C4C21D896" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EMS9</accession>
    <name>A0A812EMS9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_75326</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005455">
        <property type="protein sequence ID" value="CAE1325689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EMS9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1325689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="331" mass="40163" checksum="D97BBCC8DE06A164" modified="2021-09-29" version="1">MHFLFYFSKDTLFHHFFLSFFLSFFLSFFLSSFLSVCLSSFLSFFLSFFLAFRLFVCLSFFLAFRLSFFLSFFLSFFLSFFLSFFLSSFPSVCLSFFLSFFLSSFPSFFLCQIQIIFLSSFPSFFLSFFLSFLMFFFLSFFYLFLFPLFSFFLSFTVSFFLSFFLFLSCLLSFFLFFFFPPFFLFFLYFLSFVLLLSFFLSFLFCFLPYFLFFVPSFFLFLSFFLSFFLSFFLFFVCLFVCLFVSFFLSFFLSFLFLLYFPSFVLFLSFFLSFLLSFFLSFFLSFFLSFFLIRIFLGVLSLICSFFSILSFLLPSLSSRFIFLSYEIKFPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ES56</accession>
    <name>A0A812ES56_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_79912</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005582">
        <property type="protein sequence ID" value="CAE1330629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ES56"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1330629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="279" mass="32096" checksum="3178694C6921963B" modified="2021-09-29" version="1">MLPPPFISDVASSFHFRCCLLLSFPMLPPPFISDVASSFHFRCCLLLSFPMLPPPLISDVASFFLSFRCCLLLSFFLMLPPSFFLSDVGPSFLSFRCWLLLSFFPMLAPPFFLSDVGPSFLSFRCWPLHSFFPMLAPPFFLSDVGPSILSFRCWPLHSFFPMLAPPFFLSDVGPSISFFRCWPSILFFPMLAPPFFLSDVGPSFLSFRCWPLLSFFPMLAPPFFLSDVGPSFLSFRCWPLLSFFPMLAPPFFLFWFTLWPPHLKIIVSPFFSTVFFLIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ETL2</accession>
    <name>A0A812ETL2_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7041 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_80735</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005609">
        <property type="protein sequence ID" value="CAE1331522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ETL2"/>
    <dbReference type="OrthoDB" id="6159822at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055469">
        <property type="entry name" value="DUF7041"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327">
        <property type="entry name" value="ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327:SF3">
        <property type="entry name" value="RNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23055">
        <property type="entry name" value="DUF7041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7041" evidence="2">
        <location>
            <begin position="9"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1331522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="318" mass="36350" checksum="74C8CD0BF402F91D" modified="2021-09-29" version="1">MSAAVAPFPPFHEGNIKNWFLQMEAIFTVRRITDQKTKFGHVVAVLPPAIVDEVSDFLEAVPEVEPYARLKEAILRRMGRTEESLIRELFSNLTCDGRTPSQLLRYMKSRLGKNTMADSILKSLWLDRLPTTITQILASMSENTSIDQLADAADRIFSQLDNQTMPVHSAEATRDHSSLEKTVEDLQRQVKDLTLALKSQGRSRFPSRRRFRSRPRSSSRNKDATPTMCYYHRRFGSAAHHCTKPCSYTAVAGKQNCQRVKATNPAGKAFSPKLSRLFYVTDTRNNLRFLVDTGAEREKEIEIYSMIKREKKRLKYTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EU90</accession>
    <name>A0A812EU90_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_77161</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005506">
        <property type="protein sequence ID" value="CAE1327705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7474541at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1327705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1374" mass="154821" checksum="0D0720F6802BC34D" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EXL1</accession>
    <name>A0A812EXL1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_81258</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005628">
        <property type="protein sequence ID" value="CAE1332179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EXL1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1332179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="340" mass="38807" checksum="593D1961EABE1A9A" modified="2021-09-29" version="1">MIFFFSSIFPLFILFFSVNSFRLLKKSPFFSFHFAKTVYFFVFFPFAKTFFVSYFFPSFVKSNFDIPLLAICLHYLHSLDSFFRFFLSFVFTKIYLFFLSLYSLLKLSSLLLPSGTYIVSHFSFLFNRTVFDHATLSSWLNFSSFHFFPLLLKFFLLLSLRKKMLMELKNALPLSPAPPTLSLPYLSLPLSPSLKLSVSLSLSLSSLSLSLPLSPLPLNLPLLSSSFSLFLLSLPFSLSLSLPSPLAPFIFLFLSLLLSLYRSLFLSLSSLLPLSLHSSFSLFSSLPIYLLFSPLFSLFSSLPSPLSPSLSLSLPHSPSLSLFKRRKCLFSSRVYYKSPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EZC2</accession>
    <name>A0A812EZC2_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Small nuclear ribonucleoprotein Sm D1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">snRNP core protein D1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SPHA_81339</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Farmed</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the snRNP core protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005631">
        <property type="protein sequence ID" value="CAE1332308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EZC2"/>
    <dbReference type="OrthoDB" id="9626941at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01724">
        <property type="entry name" value="Sm_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000016">
        <property type="entry name" value="Small nuclear ribonucleoprotein Sm D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027141">
        <property type="entry name" value="LSm4/Sm_D1/D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034102">
        <property type="entry name" value="Sm_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23338">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="Sm" evidence="13">
        <location>
            <begin position="62"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="146"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAE1332308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="178" mass="20033" checksum="D096041DAAD55EC2" modified="2021-09-29" version="1">MFSLLTSSSLFLSLLSLFLFLPFLLVFFKLSSVFFYVTPVDKENKVFINVLTCLITIHLIMKLVRFLMKLSHETVTIELKNGTLVHGTITGVDVSMNTHLKAVKMTLKNKDPVQLETLSIRGNNIRYFILPDSLPLDTLLIDDTPKAKAKKKEMAAPGRGRGRGRGRGRGRGRGRGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AHD1</accession>
    <name>A0A812AHD1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000003">
        <property type="protein sequence ID" value="CAE1138660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AHD1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1138660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="225" mass="24854" checksum="60916030C5239479" modified="2021-09-29" version="1">MLLYIPSQCLFSKRRQRLEVPEQVSKFESKYPLSVLAFFLFFLSNPPSLSLLSPPTFSLLFSPQPSLLFSPLLTLLFLLTLSLLFSPDLSHSNPLSLSPSALSIRISLALSFPLSPALSLFLSLCSLHPNISRSLLPTLTRSLSLSFSLSALSFPFSPAISLPFSPSLSPVCLFHPFSPALSLSLSLSLSLFLKRYLNLIYFAFNDKRSDDQPVYLCLGQLSGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ALY4</accession>
    <name>A0A812ALY4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_1552</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000044">
        <property type="protein sequence ID" value="CAE1145051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ALY4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="302"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="330"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1145051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="350" mass="41298" checksum="9D7CFA71392B358C" modified="2021-09-29" version="1">MVRQILFFSSVAKFFFLISSDCGNVTTQKTCLPFPYYLREILDTHIYLSIYLSIYLSIYLSISACSYLFIYLSIYLSIYLSIYLSISISACSYLSIYLSIYLSIYLSHPSIYLLSIYISIYLSIYLSQPVHIYRSIYLSIYLSISFYTYLSIYLSIYLSIYLSISACSYLSQPVHIYLSIYLSIYLSIYLSQPIHTYLSLFISIYLSIYLSIYLSIYLSIYLSLFIPISVCSYLSIYLSIYLSIYLSISAYSYLSQSVHIYLSIYLSIYLSIYLSIKSLAFFLNKRRFFFLKYTKYEQCRHFFFFFSPTSLFLISLPDAPIYLSIYLSKFVHIYIFSCMFCLRYFNGGKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AM07</accession>
    <name>A0A812AM07_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_1504</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000042">
        <property type="protein sequence ID" value="CAE1144898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AM07"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1144898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="212" mass="25208" checksum="BDFDF617F793BF9C" modified="2021-09-29" version="1">MTRRHLTGRVKKLRAADGQLKQESRSAGHGYARASARETSRETSRDTAHVAGPHVHALLRALIIKSFFLFSSMCLDTFFLFFFIYIFLFFKYLFVPFLCPDFRLELSFFLSFFLSFFLSFFLYLCIPFLCPDFRLELSFFLYFFILSFLSFVLFFFCILAFLSFFLSFFLSFFLSFFISFFLYFFCSSLHFFQCIYTGFLPPTYSPNTIQTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AMW3</accession>
    <name>A0A812AMW3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_1813</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000052">
        <property type="protein sequence ID" value="CAE1146428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AMW3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="296"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="320"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="377"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="409"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1146428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="431" mass="51844" checksum="8C8D78B9B1CAA0FB" modified="2021-09-29" version="1">MDLSIYLSIYLSIYISMFSYSLSFFCLIHYYFFTLILSFFYLLLHHFLLFLSFFFLSYSFFTFLSFLIFTLSFFLSFFLSFFISSFFLHLVFLSSSRLSFFLSVFLHLVFLSSCRLSFNLSFFLSSFFLSFFLHLVFVCSSRLSFYLSFFISSFFLSFFLSSSRLSFFILCFFVHLVFLSIFLYFFLSSTRLFFFISSFFLSFYLSSFRLYLFLSFFISSFFLHLVFLPFFLSFFISSFFLRVVFLSIFHHLVFLCSSRLSFFLSLFISSFFLSFFISSFFLHLVFLSIFLSSSRLSFFLSFFLSFFYHLVFLSSSRLSFYLSFFISSFFLSFFLHLVFLSFFLCSSCLSFFILCFFVHLVFRSFFVHLVFLSSCRLSIFLCSSRLSFFLSFFLSFFLSFFLSLFISSFFLSYFLSFFCFLSSFYIQLTCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AN90</accession>
    <name>A0A812AN90_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_2549</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000071">
        <property type="protein sequence ID" value="CAE1148852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AN90"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1148852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="176" mass="20735" checksum="D27480D0C136BA62" modified="2021-09-29" version="1">MSRHLSHLSVCSHFSNLSHRFSLSLSFSLSLSLYLCIYLFKCYLICLFHLSHITYPTAIRPRHLFIHSFLSFFLSFFLSFLSFQEVHKYLSDDLYQTTFISRFDLSHSVHIYLSIYLSIYLSIYLSILVCLYLSHLSIYLSIYLSLFLYLSIYLSIPVCLYLSIYLSISVSLYLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ANL5</accession>
    <name>A0A812ANL5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_1614</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000046">
        <property type="protein sequence ID" value="CAE1145380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ANL5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="266"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="329"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="358"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1145380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="403" mass="42501" checksum="9DCBFB0EF222C808" modified="2021-09-29" version="1">MTLPSLFFSLSPCRLFSSLSLPAAFSLLSLPCTFLFSLSPPCSSLSPFFSSLSLPTVSLSLPFSLLSLSLPAAFSLLSLSSLFSSLSLPPCLSLSPAAFSLLSLSPFSSLSPPPSLSLSPRLSLLFSLPLFSLSLPCCFSFSSLSLPALFLLSLSPASLSPLLPCLFSSLSLSLRLSLLSLSLPPPFSLLSLSPCRLFSSLSLSLPPFLLSLSPCRLFSSLSLPAAFSLLSLSPYRPFLFSLSLSPAFLFSLSLPALSLLSLSLPAAFSLLSLSLPAAFSLLSLSPCLSFFSSLSLSPSRLSLLSLSLLPFLFSLSPPAFSLLSLSSPFLSLFSPLSLLFSLLLAFSLLSLSPLPSSLSLPCFSLLSLSLPAALSLSLSSFLFSLSLSLPPFLFSLSPLLFLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AQS7</accession>
    <name>A0A812AQS7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_2220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000062">
        <property type="protein sequence ID" value="CAE1147792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AQS7"/>
    <dbReference type="OrthoDB" id="9635126at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1147792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="299" mass="35115" checksum="586093B77CC74CAA" modified="2021-09-29" version="1">MHLFIYLILFIFSLSINLSIVHIYLSIYLSIYLSINLSIVHIYLSIYLRSYLSIYFNLFISFFCFHPLFIFYFSYLSIYLSIYSYVFISIYLSIYSYLFISVYLSIYLSIYLSIYSYLFISIYLFISVHIYLSLHFCSYLSIYLCISIYLSTSSYLFISIYLFISVSIDLSIYLSLHICSYLSIYLSLHICSYLSMYSYLFISIYLTTESKPMTTSQDNLTLFSFFHSLFLSFSFFLSFFFLSFFLPSVPYSLSLSLSLSLSLSLSLSLSLSNTHTAVMYLSHSPVIYHQTVSVQRQGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AR62</accession>
    <name>A0A812AR62_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_3506</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000105">
        <property type="protein sequence ID" value="CAE1152570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AR62"/>
    <dbReference type="OrthoDB" id="6153212at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF16">
        <property type="entry name" value="GP152 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
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            <end position="62"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        <location>
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            <end position="503"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="730"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="787"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="812"/>
            <end position="834"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1152570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="851" mass="96437" checksum="1B9FF2FE167B1D4A" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ASR8</accession>
    <name>A0A812ASR8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_6097</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
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            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000200">
        <property type="protein sequence ID" value="CAE1159733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ASR8"/>
    <dbReference type="Proteomes" id="UP000597762">
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            <begin position="448"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1159733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="485" mass="55993" checksum="8B80F9D7F68A6F5C" modified="2021-09-29" version="1">MENLAALQNWPYGFVADRFKNDSFSCSPFPSFFLLLSFLLHSSFSCTLILSFFLSFPLHSSFPCTLSLSLFFLMFSIYIIPFSCSPFPSFSFFLLLAFLLHAWKEELATEENNEFYCLSFLLLFLSLPSRSSFPCTLSFSLSLLDIFPLHYSLSCSPFPSFLLLLAFPSHSSFPCTLSPSLSLFLIFSLYIVPFLVLPFLLFFFFFFFLLALHIHLFLVLSLSLSLSLFLIFPFTLFLFLFSLFFFSSSSSCLPFTFIFSLYSFSLSLSLSLLDISLYIIPFLVLPFLLFFFFFFFFFLALHIHLFLVLFLSLSLSLFLIFSLYIIPFLVLPFLLFFFFLLALHIHLFLVLFLSLSLSLFLIFPFTLFLFLFSLSIFSSSSSSCFPFTFIFSLYSFSLSLSLLDIFPLHYSFSCSLLLLLLLACPSHSSFPCTLSLSLSLSLLDISLYIIPFLVLPFLLFFFFFFLLSLHIHLFLVLFLSLSLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ASW3</accession>
    <name>A0A812ASW3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_4464</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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            <taxon>Coleoidea</taxon>
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            <taxon>Sepiida</taxon>
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        </lineage>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="CAE1155412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ASW3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
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            <end position="408"/>
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        </source>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ATC2</accession>
    <name>A0A812ATC2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_6473</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Spiralia</taxon>
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            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
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            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000212">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ATC2"/>
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            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1160591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="263" mass="31088" checksum="56DF27E05C348E73" modified="2021-09-29" version="1">MYLFLLAAPPKIISLSLSLSIFYSLLFFSHFTLFDLFSLIISLSFSVFLVCFFSLFQPAFFFSLTQFFYSLLFMPIFSLSLHPVFLFFFPFNFFLLYFSSFFFLPLFSKCMLSLFFLCVSLSENIFYLLTCTLYIEQSFIFSLFFSLLIFLSLFANLRASDSEFVFRNETAACEVFPLITGRPLLLFFILFPDVSSFSNIFICFCYFFPFLFLFHFVSLLLYITPFSFLLNSSFTSPSFVFGLLLSIFLYFAIYFFFIIFLHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AUH7</accession>
    <name>A0A812AUH7_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Phosphatidylinositol-glycan biosynthesis class X protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SPHA_7131</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Farmed</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Stabilizing subunit of the glycosylphosphatidylinositol-mannosyltransferase I complex which catalyzes the transfer of the first mannose, via an alpha-1,4 bond from a dolichol-phosphate-mannose (Dol-P-Man) to the glucosaminyl acyl phosphatidylinositol (GlcN-(acyl)PI) intermediate to generate alpha-D-Man-(1-&gt;4)-alpha-D-GlcN-(1-&gt;6)-(1-radyl,2-acyl-sn-glycero-3-phospho)-2-acyl-inositol and participates in the sixth step of the glycosylphosphatidylinositol-anchor biosynthesis. Probably acts by stabilizing the mannosyltransferase PIGM.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the PIGX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000230">
        <property type="protein sequence ID" value="CAE1162094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AUH7"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013233">
        <property type="entry name" value="PIG-X/PBN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040039">
        <property type="entry name" value="PIGX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28650">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS X PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28650:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS X PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08320">
        <property type="entry name" value="PIG-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 10" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAE1162094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="151" mass="16905" checksum="C06035DA00AC873A" modified="2021-09-29" version="1">MKNCFQFFSFFHNLADCISQTLLVYLPLLSTSKTGYLKAESVLPFHLRYHQPQIGDYSRATVNINPPTHVFTNCSDGFSALEKIPCSSSDSRLCLWQKLNCKAATVTTNVPVGDFNHLIPVSVITILSTFGSTALLLHQMYKTSNVKLQKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AVK7</accession>
    <name>A0A812AVK7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_6347</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000208">
        <property type="protein sequence ID" value="CAE1160297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AVK7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1160297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="196" mass="22731" checksum="9F83DA6B0D60B001" modified="2021-09-29" version="1">MLCPIFGRHTTKADRSLRIYLGLLFLSIYLSIYLSIYLSIYLVSSYLSRSLLRVYLSIYLSIYLSLSYYIYIYIYIISVSLYLSIYLSISVFSSLSIYLSNYGHPCLSLSFSLYLSQFIHIYLSVSLYQSIYLSIYLSIYLSIYLALSLFISIYLSIYLSLRISLSLSLSLSSPRNFLSIYLSIYLSIYLSVSVHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AWT5</accession>
    <name>A0A812AWT5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_7060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000225">
        <property type="protein sequence ID" value="CAE1161841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AWT5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1161841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="198" mass="24041" checksum="DAEB36BE7050D793" modified="2021-09-29" version="1">MKIYLYSYLSIYQSIYLSIFIPILLSLFISIYLSINLSIYLFSYLFYYLYSYLSIYQSIYLSISFHTYFTIFIHIYLSINLSIYLSIFIPILLSLFISIYLSIYLSIYFHTYFTIFIHIYLSINLSIYLFSYLFYYLYSYLSINLSIYLSLFIPILLSLFISIYLSIYLSISFHTYFTIFIHIYLSINLSIYLFSYLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AYL5</accession>
    <name>A0A812AYL5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="16">GRIN2B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SPHA_8174</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000263">
        <property type="protein sequence ID" value="CAE1164715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AYL5"/>
    <dbReference type="OrthoDB" id="5984008at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000009">
        <property type="entry name" value="Putative glutamate receptor ionotropic NMDA 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015683">
        <property type="entry name" value="Ionotropic_Glu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18966">
        <property type="entry name" value="IONOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="179"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="213"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="295"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="356"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="399"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="15">
        <location>
            <begin position="417"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="14">
        <location>
            <begin position="418"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAE1164715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="559" mass="64233" checksum="617E3FDE33EE2EE4" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AYZ8</accession>
    <name>A0A812AYZ8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SULT1</fullName>
            <ecNumber evidence="5">2.8.2.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SPHA_6986</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Farmed</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfotransferase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.-" evidence="5"/>
    <dbReference type="EMBL" id="CAHIKZ030000224">
        <property type="protein sequence ID" value="CAE1161618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AYZ8"/>
    <dbReference type="OrthoDB" id="205623at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11783">
        <property type="entry name" value="SULFOTRANSFERASE SULT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfotransferase" evidence="4">
        <location>
            <begin position="142"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAE1161618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="387" mass="46266" checksum="E1604D46B5B5DC07" modified="2021-09-29" version="1">MLLNVKLIADRLRHSYLSIYLSIYLSIYLSIYLSHCYLRSKFFKNTKKYFKGVIKVVTECYLNSTKYQTLLSCASRPYAEEITEDPSFHLNTQPKKSEMPEVYYKDPDGHHVLSYDYNGYLVPPFPNVDERLDKLPNMSIRDDDIILLSYMKSGCHWVWEISNMLRRNCTEYEKNLKDIGMLELTDQDVIDTQPSPRVLNSHMLLEHLPRELLTKKTKILFVMRNPRDIIVSSYHHIFQMQNFYKYDGNWNSYFDLYMKGQVNYGKWFDYMLEWEKVFKKYPELPVLLIKYEDIKKDPVGKIAELAEFIGVEKNEEFFKEVADKCSFNKMKMHKSRGGDSFRTPGASLYRKGVVGDWKNWFTVRQNELFEEEYKKFKEKTEMFNIFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AZR8</accession>
    <name>A0A812AZR8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_7420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000238">
        <property type="protein sequence ID" value="CAE1162767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AZR8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1162767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="189" mass="22307" checksum="9DD63F49C2E04221" modified="2021-09-29" version="1">MHLKWTRRESFLYLSIYLSIYLSIYLSSLPYLSIYLSIYLSRSRLEFLHIILSSDKSSFPTLRKFSSSSSPLIFLLLFPLLLHNSVFFSGNFFPVAHIVFSYVFFTLIHPSVFFLLIFMTAKLLLFCSLQPFFIGHLPHLHFSFHQFLLDFLYFFLFLTPPPRSFRPSRHSHFSSPPPLSLDPNPFYVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B033</accession>
    <name>A0A812B033_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_10269</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000331">
        <property type="protein sequence ID" value="CAE1168805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B033"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="287"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="399"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="424"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="457"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="497"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="529"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="557"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="591"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="622"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="663"/>
            <end position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1168805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="687" mass="78602" checksum="C27194EDC2C813EE" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B169</accession>
    <name>A0A812B169_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_8779</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000285">
        <property type="protein sequence ID" value="CAE1166201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B169"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="321"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1166201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="361" mass="41966" checksum="0DC396C58747A1AC" modified="2021-09-29" version="1">MFVSFFLLDMSLHNANFSYLSIYLSIYLSFLTNFIPSALTFSDNHCVKRFFCPWVNLFIISLSLSLSLSLSLSLSLSNCPIYKAASFPLCYNHIYVLKIRLTTTTISTQLFKSVSSPTFASDTSFHKLDIIHSLVHGKNHIFSSYISFLCVPNRDFVFPFILIFFLFSFIFAFLCFLSFINYCLLFSFFLSFFLSFFLSFFLSFFLFIQQTFFSHSVYDFSFLLLSFFLSFFLFICFSPVSRLRHYFLVFLPKTIHSPSLVTLTSFHGLIFTDIGLVLSLDTLKRIRILTNLSLSLSLSLSLSLSVLLSLQRVYISFSLSFFKIVSLFHSFTISVFVFHNFLFSFFRSYSTRHNPTNLFKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B6L5</accession>
    <name>A0A812B6L5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_11116</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000365">
        <property type="protein sequence ID" value="CAE1170427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B6L5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="302"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="335"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="366"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1170427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="396" mass="45024" checksum="EDA63981CE277A1D" modified="2021-09-29" version="1">MVLIRPTVFLISIYFLCFSLSVFLCFFLSVSLLISFYLLLFLDLSIYLSIYLSIYLSIYLSIYHEGVVVVVAVDAGRVATVSAQMEPSKYSTAGRLSSRDSTLLAALSERVVVVAAADVGNRYALKWNPLSIRLQDDCLRAVQRSSCVQAALSERVVVVAAADVGNPRYALKWNALSIRPQDDCLRAIQRSSCAQAALSERVVVVAAADVDNPRRLSPRDSTLLVRADCYLCGGRRCGRLTRSSVLSFFLSLFFLSFFRSSFLSLQMFACFFLSFFFLSFFLSFFLSFVLPFFLCKCLPVSFSFLSFFLFFIKFLSFVLPFFLCKCLPVSFFLSFFLSKCLFVCFFLSFQMLISSLLLFSEFFLSFFLSFFLSLQMSVCLFLSFFLSFFLSFFLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B769</accession>
    <name>A0A812B769_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_12125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000402">
        <property type="protein sequence ID" value="CAE1172521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B769"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134:SF22">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134">
        <property type="entry name" value="OS08G0543275 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="363"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="398"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1172521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="425" mass="50129" checksum="821DB015E7545252" modified="2021-09-29" version="1">MSCKIFEAETSFIIYLSIYLSLLICMYACMYLYIYIVLISMSICSLSIYLSIYLSIYLSIYLSIYLSLLISIYLSIYLSIYLSIYLFLFQCLSVHISSMYLSSIYLSIYLSIYLSISVCSYVCMHVCIYISIFLFTSIYLSIYLSIYLSISVCSICMYACMYLYIYIVLISMSICSLSIYLSIYLSIYLSIYFNLLICQSVHIYLSIYLSIYLSIYLSLLICMYACMYLYIYIVLISMSICSLSIYLSIYLSIYLFQSAHMSVCSHLSIYLSIYLSIYLSIYLSQSAHMYVCMYVSIYLYCVNIYVNLFIIYLSIYLSIYLSIYLSISFVNKRQKRISIYLSIYLSIYLSLFLSFFLYFLVCFYLSISACFYLSIYLSIYLSIYLSQFDHYLSIYLSIYLSIYLSIYLSLFLSFFFLSFFLLFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B7M7</accession>
    <name>A0A812B7M7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_12968</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000434">
        <property type="protein sequence ID" value="CAE1174137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B7M7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1174137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="210" mass="25318" checksum="9CB99997F21C9E70" modified="2021-09-29" version="1">MQTSDITLRISQVTRERDNKREKERNLITGFLKINLKSRWVPRWLCSSLSFIFLSCLLSFLSFFLSFFLSLFFLSCLLSFFLSFIFLSFIFLSFLPPFFSFLSFFLSFFLSFFLSSLLSFLSFFHSFFFLSFFFLSFFFLSRLLSFFSFFLSFVFLSFFPSFFLSFVFLSFLPSFFSFFLSFIFLSFFSFFHSFLFLAFLYFLLSCADQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B8T2</accession>
    <name>A0A812B8T2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_12440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000416">
        <property type="protein sequence ID" value="CAE1173135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B8T2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="293"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1173135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="328" mass="39042" checksum="0A260261C0161572" modified="2021-09-29" version="1">MNLLGLSFPLTDLILSIYYLSIYLSMCVCVCPSIYCICLSVYLSIYLSIYLSIYLIKTRFYLSILSIVLKLLSISLIKTALSLSLSLSLNIIIIIICNLLLLLAIIIIITFIHILILLLSLLCFLFLFFSFCSRHLYYYYLYRFSYGYHSCSSSSSSSFHYYYYDYYYYILLLLLLFSLPLHLYYYYYIHFLLLLLLLIFYITLLMIIFLLLFIIIIIITFFFLLLFFLSFFLSFFLSSSSSSFPCHIYYYYYHHIQLLLIIFYITLLMSNFLLLSIIIIINLSFFLSFFLSFFLLLLLLLLLLLLLLLHSIFIIIYIILLMITIIFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BDS6</accession>
    <name>A0A812BDS6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">TRIM59</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SPHA_15552</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000542">
        <property type="protein sequence ID" value="CAE1224901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BDS6"/>
    <dbReference type="OrthoDB" id="6105938at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="414"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="57"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="8">
        <location>
            <begin position="150"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="209"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="267"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAE1224901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="447" mass="52569" checksum="12BE5B761F2D661F" modified="2021-09-29" version="1">MLSLNEGNYPGASCPGRNYWGGKVDQVEKKKEPVQKTLRKRNLVFDEEHFQDAFLRCIICRDVFNETNRAPKTLPCQHTFCLHCFMEMFRVEGEYRQSLTSAFRGMPRAVKIQCPTCRDSIIASEDDLRRLPNDNTILELLRFVQETGITDIAYCAKHQLQPLNFFCELCVTAVCCDCTVLDHKEKNGHIVMSMEEALKKYTPVIDSSISEMESRRQQFKEKRMEVSKRLEDVRQMEQNVSSGIKKTFQIIRDVIKEREQMLLNMSEREVEKKRSDLQENLNHIKEREENMMSQIKILETAKEEKDIQYMFNVFNMAQDSLVESLELPYRVDDDFGLSFNFEDDKMDDLASQLKDFAICLSIYLSIYLSIYLCLLLSKFVHFYLSIYLSIYLSIYLSLLLSKFVYFYLSIYLSIYLSIFVHLSIYLSIYLSSIYLSIYLSIYLSIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BEZ9</accession>
    <name>A0A812BEZ9_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SPHA_16267</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000569">
        <property type="protein sequence ID" value="CAE1227088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BEZ9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="199"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="280"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="316"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="106"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAE1227088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="370" mass="44828" checksum="5419BD3B7C1C73AC" modified="2021-09-29" version="1">MSCLFFFLFSFFFSYVFVCFFFRLSFSVSSFFFLSFFLSFFFLSAFSFSYKVQIPLTFFSLEYFIHLFSLQYRHILPSFLFVFFFTSFSFFFNKMKKVKKKDKKEGNSLPLFNIFHSSVIFLTMNFSEFIFIFFLSFLPFSFFLFFLFSFIFNFSFFSFFLSNSFSVIFLSPFFSFFTLYFSPCSFFCFTFFFSLRFYLFFLFFLSFLPFLSFLFPISFLLLLFPFFILYPLLSFPFLSLLFLSSFLLLVFTIILHTLNQSQHVFLLPQNSIFCVFFKKILYLSVCQSISFILYFFFLYSSLLSHNLFFFLAFQKFYLCLLLSIFFSFFLSFFLSFFLSVFLSFFLSSSYSLHLHLVHLLCNVPLNPKLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BHD0</accession>
    <name>A0A812BHD0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_17404</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000620">
        <property type="protein sequence ID" value="CAE1229662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BHD0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1229662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="357" mass="42518" checksum="ED4F9A679CE71F33" modified="2021-09-29" version="1">MLKKNLSLNFNFSFFLSIYLSIYHLILFFLSFLFYLSIYLSIYLSIYLSIYLSISFNFFFLSFFYLSLKFFSYFCPFFHSLSIYLSIYLSIYLSIYLTRLISLSLYLSIYLLLFLFLSFFLSFTIYLSIYLSIYLSIYLSIYLYIYIYIYIFDLSIYLSIYLSIYLSIYLSIYLSQRLYLSIYLSIYLSIYLSEFVHFSLSLSLSLSLFYFPVCSSLSLNLSSYLWIYLSIYLSIYLSIYLSIYLSLFISLSIYLFLSVPLSLNHIFYLSIYLSIYLSIYLSCLYYFVSYQSPILILFIFTCLYSSLSLSLSLTLSLSLSLTVSLSFYFLYHLSEYILASPTSLQYALFNIHSNIRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BHN5</accession>
    <name>A0A812BHN5_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EXPERA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SPHA_17739</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000634">
        <property type="protein sequence ID" value="CAE1230463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BHN5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033118">
        <property type="entry name" value="EXPERA"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51751">
        <property type="entry name" value="EXPERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="13"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="299"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="391"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="423"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="450"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="477"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="510"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="536"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="563"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="592"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="622"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="747"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="794"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="819"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="846"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="872"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="domain" description="EXPERA" evidence="7">
        <location>
            <begin position="79"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAE1230463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="901" mass="107744" checksum="6C33049DBD885D28" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BIU3</accession>
    <name>A0A812BIU3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">E3.1.3.5</fullName>
            <ecNumber evidence="2">3.1.3.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_17556</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.5" evidence="2"/>
    <dbReference type="EMBL" id="CAHIKZ030000628">
        <property type="protein sequence ID" value="CAE1230046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BIU3"/>
    <dbReference type="OrthoDB" id="10248475at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008253">
        <property type="term" value="F:5'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009223">
        <property type="term" value="P:pyrimidine deoxyribonucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.40">
        <property type="entry name" value="Deoxyribonucleotidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010708">
        <property type="entry name" value="5'(3')-deoxyribonucleotidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16504">
        <property type="entry name" value="5'(3')-DEOXYRIBONUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16504:SF4">
        <property type="entry name" value="5'(3')-DEOXYRIBONUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06941">
        <property type="entry name" value="NT5C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01145">
        <property type="entry name" value="C1.2.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01126">
        <property type="entry name" value="C1.2:_Nucleotidase_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="30"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR610708-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1230046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="222" mass="26221" checksum="F4798BBB1F05D456" modified="2021-09-29" version="1">MPRMASVTEPTTKTLTSQAQHQRRLVVLVDMDMVLCDFESYFLEKYREKYPDEPFIPLEERSQFYIREQYATIRQDLSLKCREIYCAEGFFVNIPEIPGAVAAVKEMNQIENVEVFICTSPLIGNYRYCVKEKYEWIEKHMGNDWAGKIILTPDKTLINGHLLIDDRPNIKGMIKKPTWEHVLFTACHNKNIVLSTKKKRLDSWVNEQWKPLIEEFKKKLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BJK9</accession>
    <name>A0A812BJK9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_18829</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000680">
        <property type="protein sequence ID" value="CAE1233102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BJK9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1233102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="253" mass="29370" checksum="FDB24C8742D091EA" modified="2021-09-29" version="1">MYLSISLSIYLSIRPSISLLQSVKIYLLLTKMHTSHYSNTFSLLFLSPTFSLSLSLSLSHSIKLFLFLAFFSFVYSFFLSFFIYLFIYLFIYFSPFSLSFFSPLLFLLTEVHLFFRFLGLSYSLHFHTILLSRCILSSLPPLSLSLSLSLSLSLSLSLSLSLYFSFTLFLSFFYFFFSISLSINFLLSFFYFHFPSLYHSSFVFFSLTHSLFLSLSLSLSIYLSIYLSILSSDSLQISINQPQRPVNSMNMFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BMY4</accession>
    <name>A0A812BMY4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_20357</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000746">
        <property type="protein sequence ID" value="CAE1236637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BMY4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032494350" evidence="2">
        <location>
            <begin position="19"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1236637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="385" mass="41163" checksum="820CE9D8CB7A9D10" modified="2021-09-29" version="1">MNAPGTLTLSLSLFSALSFHLSLSPLSLSTALSSHLSLFPPLSHSTSLSPTLSLSLPVSFTSLSFHRSLLPPLSLSTSLSFHLSLSTLSLFPPVSFTSLSFHRSLLPPLSFHRSLLPSISLFPPSLSFHLSLPPHFNSLLPSFFSCLFTFYCTFLDLVFICLPLLSLSLSVSPSPSLSLSLSLPLSLPLSVSPSLSLSLAPLSPLSLSLSPSPFPSLPPLSLPLSLSPSLSPPPLPYLRLSLSLAPLSFPFSPSLRLSLPLSLLLPLSVSPSLSPSLLPLSHSLSLPLSVSPSPSLLPLSHSLSLPLSPSLRLSLSLSPPLSPPLSLPLSDSVRSLSIYLSIYLSIYLSIYPHSLCLICIIPSSFFNFIYLSHKICPYFFSVSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BPM8</accession>
    <name>A0A812BPM8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_24525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000914">
        <property type="protein sequence ID" value="CAE1244885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BPM8"/>
    <dbReference type="OrthoDB" id="10286737at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="409"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1244885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="509" mass="53761" checksum="AE93BF01A92420B4" modified="2021-09-29" version="1">MMANPRPIEEDKQHELMKDVDGEASCSKSQLPLGRNASSSSCLPSQLRLSDSLAVNVNPEPSASSHHSSSPGIVLHREQATSYLYDCFSGPILGPPDQTGLSSMVKGDNTESMKVVEVDTSRGHNFHSDERPLAKPSSSNNTYNLKVCPSPITSESSYNFFQMAMYPEKVINIEEFLGVSDILITGNDDAGKKKKMSNIVPTIPTDNNSGSSCSNAIDPSGSSSLSSGVSMNLNSMVGPSTSGRFASVLNLSCYNENLDNYLKTGNNECMSSMNEASMASGAAGRNSENVVNLSQHVACPSGSSVTKVVVTSAVVDRPGSSNVVNPNGIIASTGVHHAAGSNHKAVVVNVPNLGAENGIRGVENGGQKIHNEQIPNQAENDLEMEFYESVIELENEYNGNNAREGRETNLSSSLPLSNGNNLDTSATTVANGGTALSGSPAAEGTNGMAGAATPTASDILKCTICTKTFNSFFSFSIFSSSPHTCLHLVQQGYTFFIFLFSLLLDSLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BQ02</accession>
    <name>A0A812BQ02_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="19">GPR158</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">SPHA_21410</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Neuron projection</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Postsynaptic cell membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000786">
        <property type="protein sequence ID" value="CAE1238648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BQ02"/>
    <dbReference type="OrthoDB" id="5823771at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043458">
        <property type="entry name" value="GPR158/179"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054714">
        <property type="entry name" value="GPR158_179_extracellular"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32546">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 158-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32546:SF26">
        <property type="entry name" value="SMOG, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22572">
        <property type="entry name" value="GPR158_179_EC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <keyword evidence="13" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="134"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="18">
        <location>
            <begin position="136"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CAE1238648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="225" mass="25690" checksum="BB3EB6224B7243DC" modified="2021-09-29" version="1">MISNYRNHFFFSGIVVVDIDLNKVQINQCAKDGSLFSNSHKCRLETTECVAVPVIGKFKRGSYRCQCKPGYYFPTLNASHNYFNGTLVENQLLERLRNGSTQADPLSDSFQCQPCRKGCPNCVSDQPCFVEYNILLRGIPLGIQSFCMTITIVLALVIFRLRKSKVICNSFWAMLELLLVGSLLLYSTVVIRYFEPTMLTCLLVPWFREVGFTIVYGVLILKMYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BR11</accession>
    <name>A0A812BR11_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_21312</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000780">
        <property type="protein sequence ID" value="CAE1238429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BR11"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1238429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="224" mass="25925" checksum="81CE8247B3BAB0EF" modified="2021-09-29" version="1">MLPTLLPFFSFSISFASIFFVLLLLLRQLNILFASTFSVFLYFSFFFCILNEYTSSLFLLLHCDFFCSSVYLLLFLQHPKCFYYFYISSSPSTSSTSYVLLPLHDIFFSYYYSSSSVLLRLLYFSLSASTSSFLFFFFFFSGILSVSNSSLLSLLIFFLLLLLLLLHSLHALRASTASVYIIFFSASYVPLPLLKFSFFFFSILIASTSFEFLLLLLHLYLLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BS48</accession>
    <name>A0A812BS48_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_25858</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000984">
        <property type="protein sequence ID" value="CAE1247842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BS48"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032781448" description="NADH dehydrogenase subunit 2" evidence="2">
        <location>
            <begin position="22"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1247842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="294" mass="34608" checksum="B772ABA88654C911" modified="2021-09-29" version="1">MPVRWHYVVLFFCFSAPGVLSGKCIRSIYLSDFHSIFLSIHMAFYLSTCLSDFILSLFLYFFLSIWLSIYLSIYLSIYLSIYLSDFHSFYVYGFLSIYLSIYLSIYLSISIYLSDFHSFYVYGFLSIYLSIYLSIYLSIYLSACLSVRLSISVYSYLSIYLYYYLSIYLSIYEGIKTIGKLFLIVFFPFILSIYLSIYLSIYLSIYLSKPVHYLSIYLSIYLSIYLSIYVSLFISLNLSLYLIIYLCRLIARLACSYLFISMPPSVTSNFHPSIYLSIYLSIYPFLSLLVYFCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BW27</accession>
    <name>A0A812BW27_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_23740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000879">
        <property type="protein sequence ID" value="CAE1243295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BW27"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="155"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="191"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="351"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="240"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="284"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1243295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="384" mass="43398" checksum="B8D6085E3836528A" modified="2021-09-29" version="1">MLNLFLPFLRPYMSQDFSLSSYLFSRYHLFCSYFFSFTFTFYSVTPTRLQSTQPLPSTRFPPNSYSTLPVYSILLFNFLFLFSFFFFPTSYSAYLVSLLFLTDFIWVFIIKKNISFLFFCIIFLLFLNSLTFSLFPSSLPLSFVFSLSLSLFLSLSLYLSIYLSIYLYIYIYIYIYIFLNNVSSSSYYSSSFFFFFFFSVSSSSYYSSSFFFFFFFFSVSIPPPYFFFSASLPPRSSSSSSSSASLHPPITPPRSSSSSSSSSSSSSSSSSSSSASLPPPITPPRSSSSSSSSASLPPPITPPRSSSSSASLPPPITPPHSSSSSASLPPPITPPHSSSSSSSLFLFFNTYYIYTYIHTYLSIYLSIYLSIYLYICRNFSKSND</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BWW3</accession>
    <name>A0A812BWW3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_25591</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000968">
        <property type="protein sequence ID" value="CAE1247282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BWW3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="313"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="398"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="422"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="449"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="479"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="505"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="544"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1247282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="586" mass="72447" checksum="97EE1B53CC0C27B3" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BY88</accession>
    <name>A0A812BY88_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_27742</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001086">
        <property type="protein sequence ID" value="CAE1251928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BY88"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1251928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="403" mass="45483" checksum="1BAEAB6F90F2967D" modified="2021-09-29" version="1">MFLLSLTEIYQFLYNQPIASSYSSQHLPSTSCRHYSLPSLFIPEVDVIIVFPASSFQKLTSLYLPSLFLPEVDVIIVFPASSFQKLTSLYLPSLFLPEVDVIIVFPASSFQKLTSLYLPRLFLSEVDVIIVFPDSSFQKLTSLYLPSLFIPEVDVIIVFPPSSFQKLTSLYLPSLFLPEVDVIIVFPASSFQKLTSLYLSSLFLPEVDVIIVFPASSFQKLTSLYLSSHFFSEVDVIIVFPASSFHKLPICRHYSHRSIFLPEVTVIIVFSASLFQKLPSLYSFQPLPSTSCRHYSLPSIILPEFASSQPLPSTSCRHYSLPSIILPEFAVIIVIAASSFQKLPNYRHYILSSLFLPEVAVIIVFQHYPSRIGRHYSLLSIFLPEFPVIIVFPASSFQTLPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BYD4</accession>
    <name>A0A812BYD4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_25244</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000954">
        <property type="protein sequence ID" value="CAE1246528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BYD4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="316"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="345"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="380"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="415"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1246528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="436" mass="50549" checksum="B2F7676997D9E1AC" modified="2021-09-29" version="1">MIVCLLFSLPRFTPLHDVISLVLKLCGQGCSSRCNLEVIFKDYILSFSLTFSLSLSLSLSLSLSLSLSLSLKYNSGQGICIDISFVCSCLRLFCCVFSKSDAEYLIYQKTIVNIALYLLNYLLSVFVSIYLSIYLSIYLSIYLSIYLSLFSIYLSIYLSIYLSIYLSISVYSVSIYLSIYLSQSIQYLSIYLSIYLSIYLSLFSIYLSIYLCISVYSVSIYLSIYLSLFSIYLSIYLSIYLSLFSIYLSIYLLYYNTISECSLSIYLSIYLSIYLSMRFTFPYSFFLFYPSDTLRSSISNANFSFFKNVFLSSKCFLYFCLFIIYLILFIIYLSIYLSIYLSKSVHYLSIYLSIYLSLHLSFLFWSYLSFARVLSIHSCLFIFLSLFSPYLSIYLGLFICLAHCLSFSLHSYLPTYFSMYSSRSVIAFSLLIYLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C3I5</accession>
    <name>A0A812C3I5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_27679</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001081">
        <property type="protein sequence ID" value="CAE1251759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C3I5"/>
    <dbReference type="OrthoDB" id="6412674at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1251759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="262" mass="30235" checksum="E6370FB2A5753019" modified="2021-09-29" version="1">MLLGPVVRGCIDLKTPILCENRRPQQISIKTSWPVLHCCKKDFCNKQVMPTLPVDIKGSVIILFRSISIYLSIYLSIYVSVSIYLSLFISIYLSIYHIYLSIYLFLFYSSIYLSIYLSIYLSQSVHIYLSICSIYLFIIYLSHLSISVCSYLSIYLSISVCLYLSISVCSYLSIYLSIPVCSIYLSIYLSIYLSIYLSLFIYLSIYLSIYLSIYLSQSVHIYLSIYLSIYLSIYLSIYLSLLISIYLSISISSYLSIYLSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C9A6</accession>
    <name>A0A812C9A6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_29260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001162">
        <property type="protein sequence ID" value="CAE1254953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C9A6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <end position="45"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="105"/>
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            <begin position="111"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1254953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="211" mass="23353" checksum="830FAB3A80AF5B31" modified="2021-09-29" version="1">MLHVYTLLSLFSLSLNIISQKSLFLSFSLSLVLSLSLVLSLSLVLSLSLSLVLSSLSLFLFLLFSLSLFSLVSRFSLSKCSLSRVLSLVFSLSCSLSLSLSRSLSLSLKEAVLSISFSLYLSLTFFSLFLSLSLSLSVSLSRGGLPSLLECFFLSLILSFYLLTIIYFTPTHSYHPPISIYLPTYLQTFPLSFFLTPTHLCSFVSPSFIHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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    <name>A0A812CAF6_ACAPH</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001278">
        <property type="protein sequence ID" value="CAE1258510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CAF6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
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        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="422"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="450"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="492"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="609"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="640"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="652"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1258510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="690" mass="80774" checksum="DB2B5AC3C359000D" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CET6</accession>
    <name>A0A812CET6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="2 3">
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        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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            <taxon>Coleoidea</taxon>
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            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001704">
        <property type="protein sequence ID" value="CAE1272894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CET6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1272894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="181" mass="20003" checksum="99B949907424DDA5" modified="2021-09-29" version="1">MKAVYLRNVGNHISIYIYLFKSLSISLLSLEIPALLSSARASEIPGLRRARLNNNGQIARTDAQCFVHGQLYDAAVSPLTDLSHQFFIPKQPSFMSLFNPFFSSPSNRCFFSLSSLSPDTITSTGSVASTNNLHFLESFDLVFCLVSVTPCFKKAILRRSVESILALLKAAATTFRTKLCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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    <name>A0A812CF42_ACAPH</name>
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        <recommendedName>
            <fullName evidence="3">SSD domain-containing protein</fullName>
        </recommendedName>
    </protein>
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    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
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                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="CAE1264272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CF42"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
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        </location>
    </feature>
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            <end position="737"/>
        </location>
    </feature>
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            <end position="721"/>
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    </feature>
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        <location>
            <begin position="184"/>
            <end position="302"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAE1264272.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="737" mass="82999" checksum="D173AC9512660A21" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CIS4</accession>
    <name>A0A812CIS4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_36119</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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            <taxon>Metazoa</taxon>
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            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001572">
        <property type="protein sequence ID" value="CAE1268530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CIS4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1268530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="207" mass="23604" checksum="8BBACD198240F4CE" modified="2021-09-29" version="1">MSPIETRVVIIYLSIYLSIYLSIYLSIYTHINVLITIYLSIYLSIYLSIRKHMKTAKGSQVTALGFSSLLTNTKIYLSIYLSICFTFAPFLCLFFFQSVHIYLFIHISILLSLFTTKFLQITLYHLPLLSISSCSYLSIYLSIYLSIYLNQSVLLRLNNLVSSGRFVCHWSQTATQLSPVAPRICRMQQRPPAGNRFGGPPKPGEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CK13</accession>
    <name>A0A812CK13_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_35544</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001532">
        <property type="protein sequence ID" value="CAE1267295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CK13"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="308"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="386"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="415"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="449"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="493"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="536"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="568"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="595"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="621"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="662"/>
            <end position="687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1267295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="689" mass="79007" checksum="3D39AFE322F5085D" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CLC2</accession>
    <name>A0A812CLC2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_36228</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001580">
        <property type="protein sequence ID" value="CAE1268720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CLC2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1268720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="263" mass="29840" checksum="662CA91DD7ED91AA" modified="2021-09-29" version="1">MFIHLLSLKFFFLGFIQSHTLSNLFLFLSLVLLLLSTFSFLFTYLHSPYLHFPSFFTIKCYLPSISVSLSLFLSLSLSLSVSLCLSLSLSFYCSLVPLIDAVKQKLLLMISFFLSFFLSFFFSFFFFSFIPILCSLLNTPYSKLLTFQSQLVPTRCVFDHCTVSFLLPSPNICVPIIPDTHRNLQTSFQAYPSFLVLSLISYFSFFLSVFLSFCLTLSALRPPGLPTCSFVGLSERSFVRSSAALFGYSDVFHTPPLLFTPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CLL0</accession>
    <name>A0A812CLL0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SPHA_37613</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001679">
        <property type="protein sequence ID" value="CAE1272257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CLL0"/>
    <dbReference type="OrthoDB" id="9049620at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23304:SF189">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23304">
        <property type="entry name" value="SPOT2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="203"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="286"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="988"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="406"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="7">
        <location>
            <begin position="478"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAE1272257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1012" mass="116438" checksum="B60024F5AA8EF64C" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CLU6</accession>
    <name>A0A812CLU6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_36997</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001635">
        <property type="protein sequence ID" value="CAE1270296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CLU6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1270296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="313" mass="36625" checksum="10D49CEDBDEF33FA" modified="2021-09-29" version="1">MFFFIVCSTPDFSRACDKLSASSLSLPAIDIRFLSFFLSFFLSFSSSSLLLAALKVNDIFSNNNEQKGQALTGKKNSNNRDFVFRSFLLWVNLTLSLSLSLCVCVYLSIYLSIYLSIYISLSFYIYLSLSLYLSIFIYLSLSLYLSIYLSTFIYLSVFISLYLSLSLYLSISIFISLYIYLSLSIYLYLSLYIYLSLSIYLYLSLSIYIYLYLSIYLSIYLSIYLSLSLSSYLSLSFSLSIYLSIYLSIYLYLSICLYLYLSLSLYLYISLSLSLYIYIYIYIYIYIYIFIYLSFFTSLYLFLSIYLSIYLSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CMF9</accession>
    <name>A0A812CMF9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_38028</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001719">
        <property type="protein sequence ID" value="CAE1273216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CMF9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="301"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1273216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="450" mass="50812" checksum="7A692198512B625B" modified="2021-09-29" version="1">MIKASELIDFVSPPVQINIPFLLSSSLAVETSFLPPAASVLIHCISFRQSTTNICLRLTHVIADGGPTILDSSSSSDFSSFHRILFLLFFFLIHLRIFLLLWNVFRILLLSYILLLLFIGFLCGFFFFFGFFFFSCLLNPFNSFSFFFVFGFFFFFFIDSCCCCCSDSSSSSSSSSSSSSDFILVFSVSFFFFFVIFFFWVLFLFIESIYFFFVFFFSSSSSSSDSFSSLSDSSYYYSSDYCSSSLDFSSSLDSSVSSSTLDSSSSCSDSSSLYFSSSGSSSSDPSSSDSSSSSSSSSSSFLLLLFFFFFFFFFFFFFFFFFFFFFFFFFFSSSSSSHSSYSSFSDSSSIDSSLDSSFSGSSSHHLHHHHQSYDRPRVGSAQNMPFLNPYKRVQGRFTSPKRTPPFGVASFGFLPPKAESSTDQPATTSIYLSIYLSIYLSIYRYGLSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CMQ8</accession>
    <name>A0A812CMQ8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SPHA_41808</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002020">
        <property type="protein sequence ID" value="CAE1279458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CMQ8"/>
    <dbReference type="OrthoDB" id="2213137at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF284">
        <property type="entry name" value="EG:103B4.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032776466" evidence="3">
        <location>
            <begin position="20"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="221"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAE1279458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="330" mass="36356" checksum="B489DB85D11AEA9F" modified="2021-09-29" version="1">MLCVGPFVLLLMMFNVSHRQVIICGGFVSSVATAGGFFVDQVEVLYLTYGILSEIQLKSVNEFLLKPESGFDPDDKPTEYEEGTNTNNLDNSENPGHSVNELPTNMIKRFSSKCTYLHKIIFDLDVMKNTGMQLLLTVYFFWSSCEKIYIYLPAKVVNVGLTREQGALIMSIVGAIIGPSQIITGILGDLLHIPVSYLLMPSLFGMSATTLAFTFCNTFSFFALCASLFAIFYGVAFTLRMVLVASILGGRNLTQGYSPLCLLIGITYIIDTKIAGSLFDATQSYDSIFYFTACTLFIAGIALIYLSVHISIYLSIYLSIYLSIDLSICG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CMX7</accession>
    <name>A0A812CMX7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_37739</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001691">
        <property type="protein sequence ID" value="CAE1272571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CMX7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1272571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="260" mass="29033" checksum="E9F6AA9CD20A5E66" modified="2021-09-29" version="1">MYSKSAGCISNLFLQLFSLLFLLLSILFPSFSSSSSSSSFSFSSFPFFFYIFFFIFFFFHFFSYSSPYFSTFNYFLSSSSSSSSSSSFSSFFFFFYSFFFFSYFQSCSFLLPLLLLSALLFSFLLLLSILFPSFSSSSSSSPTSSSSFFLLLSGLVPFFFFFILFFIFVFFQHFSLLLLLPILCLSFSSSSSSSSSSSSSSASSSSSSFSCFLFLLLHFILHLLRLLSALLPPPSSSSSSSSSSFRSFPSTTSSSSFSMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CP03</accession>
    <name>A0A812CP03_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_39556</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001846">
        <property type="protein sequence ID" value="CAE1275586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CP03"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="299"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1275586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="329" mass="39169" checksum="EE5A5DA7A58455AC" modified="2021-09-29" version="1">MIPFFLLFNTFPSSLLYFSLHTHSFFFSSKEFCFILFQLFIFFFFPHYQLCLVISLSFYYISFLNIFSFLVTNFLLSLSFSFPPIYFLFLFFNSLSPSYLFFLSFTHFSVSLFLPAIFLFFLSFTHFSFCFSLSFFQLFLYFSSLSPISLSVFLSLSSSYFSIFPLFQPFLFLFFSLFLPAISLFFLSFTHFSFCFSLSFFQLFLYFSSLSPISLSVSLSLSFSYFSIFPLFHPFLFLFFSLFLPAISPFFLFSSHFCFCFSLSFFQLFLYFPLIQILRLISLFSSLSSNHFFQLFPSIFFLFLPAMSFLFFSLFFHLFLYFLLILSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CQG8</accession>
    <name>A0A812CQG8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_40385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001902">
        <property type="protein sequence ID" value="CAE1276873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CQG8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1276873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="212" mass="24783" checksum="56D089561F00629E" modified="2021-09-29" version="1">MNTSIYLSIYLSIYLSIYLSIYLYIYIYIYITVCSYVSVYLSLFISTYLSLFISIYLSIYLSIYLSIYLSISFFRTLTSSSHFSFTFFAVTFSPDDNNPVTLLFILLSVLLEIVFFRPLFFFFRSYGDLSDAEPVFSLLLDQTDVFFECILLQGFNTFSHLFKSIYLSIYLSIYLSIYLFQSLHIYLYIHLSQSAHMYPSISVCLLRGTAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CR47</accession>
    <name>A0A812CR47_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_41941</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002024">
        <property type="protein sequence ID" value="CAE1279699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CR47"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1279699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="198" mass="24277" checksum="02387F3A7B1C363F" modified="2021-09-29" version="1">MIVHLYKSFFFFLFHSFCFCFFFVSFFFFFILSASVSLLFTFSFFFILSVSFFFLFSFFFILSASVSFFFLFSFFFILYASVSFLFPFSFFFILYASVSFLFPFSFFFNCFFCFFFVSFSFFCFFISVSFLFPFPFVYCSFISVSFFGSFLFLFFCSFCFFLVSIFFLFHYFFFLLSFSCFLFVFLLSFFFHFSFSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CRG8</accession>
    <name>A0A812CRG8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_42075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002035">
        <property type="protein sequence ID" value="CAE1279967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CRG8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1279967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="221" mass="24986" checksum="C9274F616421D754" modified="2021-09-29" version="1">MIWKPKEESLLSALPCNSIFSFFSFSFVFSLSSFSLISLSSFSLISLSSFSLISLSSFSLISLSSFSLISLSAFSSPSLSSRFFFSFSFLSLFLLLLFPLAFSSPSLSSRFSSPSLSSRFFFSFSFLSLFLLLLFLSLFFFSFSFLSLFLLLLFPLAFSSPSLSSRFFLLLLSSRFLLLFPLLLFPLLLFPLLLFLLLLFLLLLFLLLLFLLLLCSFHCSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CTL0</accession>
    <name>A0A812CTL0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">TrissinR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SPHA_40794</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001936">
        <property type="protein sequence ID" value="CAE1277674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CTL0"/>
    <dbReference type="OrthoDB" id="5964776at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF9">
        <property type="entry name" value="LEUCOKININ RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="1"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="122"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="232"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="122"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="240"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="260"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAE1277674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="379" mass="43129" checksum="F8CBB73903725FF8" modified="2021-09-29" version="1">MSLTIPVVLLSVISIERYLAILYPLKTKQLFTFRRLRLTQALIWLFLAAYNSPQLIVHDTFTLGDKTFCYMRSDNINTNAYVLANLIVWYILPLFVLSFMYCKIAAVLWRSSSTQNFALQMKRPEESARHTNMDAETASRTSGIERPEKPGAPAVHVSKKNKCIRMLSVQKPGGYSGVIRLQNTSIVVSREETENDSMSEYSDAESNSEVYMNECGVCGSWCQETEGEPHIGAMNVGDQSKPSSSSSKPWSNVRSGLGRKVKETENGERNNIEAVTSSGRHFYFRNKPLVNTQKVMQARRKVIRLLLIIIGTFAVLTLPYHIRACVYLWTDTKNIGSLLSPICYLLYYMNSGLNPFLYAFFSDNFRKSLKDSFKCLFRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CYT2</accession>
    <name>A0A812CYT2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Liprin-beta-2,Liprin-beta-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SPHA_44149</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002238">
        <property type="protein sequence ID" value="CAE1283596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CYT2"/>
    <dbReference type="OrthoDB" id="6516566at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048786">
        <property type="term" value="C:presynaptic active zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007528">
        <property type="term" value="P:neuromuscular junction development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09566">
        <property type="entry name" value="SAM_liprin-beta1_2_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09569">
        <property type="entry name" value="SAM_liprin-beta1_2_repeat3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000005">
        <property type="entry name" value="Liprin-beta-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000007">
        <property type="entry name" value="Liprin-beta-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037618">
        <property type="entry name" value="LIPB1/2_SAM_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037619">
        <property type="entry name" value="LIPB1/2_SAM_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029515">
        <property type="entry name" value="Liprin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12587:SF14">
        <property type="entry name" value="AT31531P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12587">
        <property type="entry name" value="LAR INTERACTING PROTEIN LIP -RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SAM" evidence="4">
        <location>
            <begin position="80"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="4">
        <location>
            <begin position="171"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAE1283596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="325" mass="37586" checksum="3E31C983BEC6EE50" modified="2021-09-29" version="1">MFLLFTGMVNYLKEIYLNEIGLDMYVTEARRWVKIGDQLLKATHHDLEKELGMKNYLHRKKLQLALEAVNVGPKERISVLSFNWVTRWLDDIGIPQYKDSFYDARIDGLMLHYMTVDDLLSLKVTNELHHISIKRAIQALRHHNFDPQCLKRRPSADEGNLQNIANEVMLWSNHRVMEWLRTIDLSEYAPNLRGSGVHGALMVLEPRFNAELFSQVLSIPANKSLLRRHLSTHFVSLIGNDQQHKKREFETSPDYQPLFPNTKVKRRNNFLLFGHKRSKSESQTDSYICPIETPPSQNGKDTLVNGGTANYPQNNGCIKEVSMLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D178</accession>
    <name>A0A812D178_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_46950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002513">
        <property type="protein sequence ID" value="CAE1288145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D178"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1288145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="313" mass="38491" checksum="5896A8212FFA72AE" modified="2021-09-29" version="1">MFILSLSVVSLFSFFFHHSIRRSFFLSFFLSFFLLIFSLHSFLSQYSTFFRSCILSFFLSFFLSFFLFSFFLSSLQYLTFQILSFFLFFLFFFFFVLIFLKFFFFIPIFDVFFFFFFSSLQYLKNFIFLFFFFPLFFLLKKFIFFKFFFIPIFHVLFFPNKLHFPSLPSEFFLFFFPLNVRIHFFLSFFRSFFLSFFLSFFHPIFNKLHFLSRLLNFSFVFPLNVRIHFENSFFFFKFSFLLSSPSLEKAKVFQIQAFGYLSIYLSIYLSIYLSIYLSVIDIISLPNLLSFFFLSLLTLSFFLLSFFFHFIDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D4F4</accession>
    <name>A0A812D4F4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_49277</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002800">
        <property type="protein sequence ID" value="CAE1292389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D4F4"/>
    <dbReference type="OrthoDB" id="9635126at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134:SF22">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134">
        <property type="entry name" value="OS08G0543275 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="291"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1292389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="317" mass="36863" checksum="5B2EF2105B54803E" modified="2021-09-29" version="1">MTNLIGIRNQLFDLSLFTFIYLSQTVLLFTSIYLSIYLSISDCSPVYIYLSIYLSISVCSYLSIYLSIYLSLFISIYLSIYLSIYLSIYLSQSVHIYLSIYLHLFTSIYLSIYLSIYPSIYPSIYLCLFTCIYLHLFTSIYLSIYLSIYLSIYLNCFIFIYLSHSVPIYPHIYLAIAANNFFLSFLLSFFLSFFLSFFLSFFLILAANNFFLSFLLSFFLSFFLSFFLSNLGFFSACLFLSFSLSLSLSLSLSLSLSGHLFKFKGSCEFWNLSIYVPIYLSMYLSISVHNYLSMCLSSISVCSYLCIYFNLLIYLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D558</accession>
    <name>A0A812D558_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Fibrocystin-L</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SPHA_46773</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002491">
        <property type="protein sequence ID" value="CAE1287779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042995">
        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00603">
        <property type="entry name" value="IPT_PCSR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055401">
        <property type="entry name" value="CEMIP_beta-hel_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052387">
        <property type="entry name" value="Fibrocystin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019316">
        <property type="entry name" value="G8_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46769:SF2">
        <property type="entry name" value="FIBROCYSTIN-L ISOFORM 2 PRECURSOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46769">
        <property type="entry name" value="POLYCYSTIC KIDNEY AND HEPATIC DISEASE 1 (AUTOSOMAL RECESSIVE)-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24606">
        <property type="entry name" value="CEMIP_beta-hel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10162">
        <property type="entry name" value="G8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01833">
        <property type="entry name" value="TIG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01225">
        <property type="entry name" value="G8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00429">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51484">
        <property type="entry name" value="G8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="369"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="2231"/>
            <end position="2252"/>
        </location>
    </feature>
    <feature type="domain" description="G8" evidence="12">
        <location>
            <begin position="230"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAE1287779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="2289" mass="255411" checksum="2F2F0E63DBDB7CED" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D5I4</accession>
    <name>A0A812D5I4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_46523</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002457">
        <property type="protein sequence ID" value="CAE1287293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D5I4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032355557" evidence="2">
        <location>
            <begin position="21"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1287293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="206" mass="24558" checksum="6B6F49EBBAC1C444" modified="2021-09-29" version="1">MLNLSLPLSLFFHIFFFANGRRYGHGLLVDLSTRPGGSHQHRSTADVWHLVWESWNIELGDTTTAWHYLERGPKLYLSIYLSIYLSIYLSMRTVYLSFFLSISTVVCLSLLMIYLFMRIIFLRSFFHLYLAFDSLYPIYFFLLSFLPFVVTFFSFFLFLSFFLSFFLSFFLSFFLSFLFLEPFLSLCPLILFFLSSFLWKPFLSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D8G0</accession>
    <name>A0A812D8G0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_51712</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003152">
        <property type="protein sequence ID" value="CAE1296912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D8G0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="688"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="711"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="839"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="894"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="966"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="994"/>
            <end position="1016"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1296912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1076" mass="123122" checksum="6F30BC7498604D84" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D8G8</accession>
    <name>A0A812D8G8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_51734</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003156">
        <property type="protein sequence ID" value="CAE1296947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D8G8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="292"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1296947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="379" mass="40762" checksum="071B59C885D2C2D0" modified="2021-09-29" version="1">MRRDQSALFIDQADRRAERAGDQRDQEGEDRVRPELHDIAHAVGGQGCREDDGVPIGRTGPSPRPPDWPEARREIVGTEGRVRARSARRACRRRGREPCPSDQFDGHATDAEDLAHRMDRIAAQLGDGRVELIGGTFTATSQVDIDEALDDLRLGGGEDGAAIECGQLRHAVDLVSGNRVERREARATSSVRQSFRSRPTRMIAMTSAWRTRASVIAFASTRSAGIDRRGRRHDGAGSPQNGGDKVAVMRRRRWRRPPARIRRWSGVIPIAKSARQPAAGGRAVIAGKPMLAGSSRQASASARRQRPPMLPATANRGDEDQGGPKPPPPRAAPPAPGASGSATRAVARSISGGRARDAATAEKAVAGGRGHRLARSGPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D959</accession>
    <name>A0A812D959_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_48780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002743">
        <property type="protein sequence ID" value="CAE1291515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D959"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1291515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="237" mass="28033" checksum="01A6A801E7556506" modified="2021-09-29" version="1">MLFIPSLLNSHLSSFFSLIDSLRFLIFILFYCSYLSIYLSIYLSIYLSIYLKLFISIYLSIYLSIYLSIYPVPSIYLYLSQPIHIYLSIYLSIYLSIPNNLYLSIYLSICFILYIIYLSIYLYIYLSIYLSILSIYLNLFISIYPCNNPIYLSIYLSIYLSIPSHPIYSYRSILTNSYLSIYLSIYLSIYLSMLSFISPLQPLVYYLHSFSTDPRICSFFLLISLSPPVFRLHHAFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DCG7</accession>
    <name>A0A812DCG7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_53380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003399">
        <property type="protein sequence ID" value="CAE1299699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DCG7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1299699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="351" mass="38870" checksum="40BD24473614123D" modified="2021-09-29" version="1">MTSQCVCFPPLQLFNPCFSLPCVISPCNVPLNTSPAFLLQLFNPCFSPPCYLIPSAFLPFSYSIRAFPSLVISCNPLQSRVIQSVLFPPLLSHVTPSPVHERCVTVCRPMKSCNALQSKHSHDVTMMSQFVCFPPLQLFNPCFSLPCYLIYSIRAFSSLLSHDVSTPPVQRCDYSRPMSLNTHDVTVCLLSSPSVIQSVLFLPCYLIYSMCFSSLVISLTPPVLLFSSNEIHDVTVCLLSSLQLFNPCFSLPCYLIYSIRAFPSLVISCNPLQSRVIQSVLFPSLVISCNPLQSRGVTSQCVSFLQLKCLNPLQSTSSMTSQCVLLSFPFSYSIRAFPPLLSHVTPSSPEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DH54</accession>
    <name>A0A812DH54_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_53510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003413">
        <property type="protein sequence ID" value="CAE1299920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DH54"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="301"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="326"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="354"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="389"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="413"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="438"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1299920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="471" mass="55951" checksum="028257115655D428" modified="2021-09-29" version="1">MFCASFIFVVATTCRLTIHLRVLSGYEFFLPKKIHVVHVTQFLKFLSESVHYLSIYLSIYLSIYLSIYLSIYLSLYISIYLSLYISIYLSIYLSIYLPTSSVHIYLSLYLSLYISIYLSIYLSIYLSIYLSIPSLYISISISVCTYLSIYLSIYLSIYLSIYLSYLYISIYLSIYLSIYLSIYLSIYLSILVCTYLSLYPSLYISIYLSIYLSIYLSIYLSIYPSLLIIYLSIYLSIYLSIYLSIYLSIRVCSLSIYLSIYLSIYLYIYLSIYLCLSISPLHSLCFPSFFFLIRYFLSHSLFSFCVINLPILFCLSIYLSIYLSIYLSLLFIFVYFSFFLSFSLSIYLSIYLSYFFYLSIYLSIYFFLLSIYLSIYLSLLFLSYFLSIYFFYSYSCIFLSFSLSIYLTICLSYFFFLSFFLSFYLSIYLSISFIHIRVFFFLSFFISLFLSIYLSIYLSIYSLTIHEDENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DHN3</accession>
    <name>A0A812DHN3_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tetraspanin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SPHA_52497</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003271">
        <property type="protein sequence ID" value="CAE1298219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DHN3"/>
    <dbReference type="OrthoDB" id="10033535at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAE1298219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="215" mass="23904" checksum="C866EA2BEF88C031" modified="2021-09-29" version="1">MLSLGLFLAGALFHKDLYGFASFLSRYICIPTIVSLSLGSFLTCIFSLTLLCFAPNIHLYAPYKCFFSGVLFLEFITWGATVFSKSFLLGLIIDSLYHAASKYTINSQANLTWDALQLDYRCCGVYNYTDWFHYLKDSIVPDSCCVNYTIGCGVFNSTSTIVETGCAEALSKWLDGCLLLTTILFFVFMLLQGISFTLSSKDQGFDSELSPVTTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DIP1</accession>
    <name>A0A812DIP1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_52491</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003271">
        <property type="protein sequence ID" value="CAE1298242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DIP1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1298242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="179" mass="20894" checksum="CA2FA4182D7DEEAB" modified="2021-09-29" version="1">MTAAQGKFTKFSFIHSFFLSFFLSFTISPSTREIHEVFIHSFVLSFFLSFFYHISVNSFFPSFFLSSTMTLVVHFKLFVSDQLERKMNFARLSSSSHSDIQKTRPVRNRPVVTAFVPVVHLSIYLSIYLSIYLSQSVHTYLNFIILLSIYQSQSIHTYLIFSSIYLSIYLSIYLSIYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DLQ1</accession>
    <name>A0A812DLQ1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_58710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004034">
        <property type="protein sequence ID" value="CAE1306438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DLQ1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1306438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="237" mass="28488" checksum="B3B9B72AD6E86DC4" modified="2021-09-29" version="1">MRYQCQPRGLVIFRQFRSKCGYLFGFSSERPFYLHKEICNVFFDFSFSSIFFLSSPFSFFFLLYLLLFIFFFISSSFFFFFDFSFHLLLLLFFYFLAVATVVTSFIHCRTPRFSFPSPQIHTHAPLLSIYSFLTIYLSIYLSIYLSIYLSIYLTKLIHIYLSIYLSIYLTKLIHIYLSIYLSIYLSNQAYSYLSIYLSIYLSIYLSIYLYLTKLIHIYLSIYLSIYLSIYLSIYLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DMQ5</accession>
    <name>A0A812DMQ5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_54605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003556">
        <property type="protein sequence ID" value="CAE1301742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DMQ5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1301742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="194" mass="21821" checksum="779762698D3B0A04" modified="2021-09-29" version="1">MPLVRTLPDQAGGGGHSRQPDSSIYLSIYPRLFISIYLSIYPDCIYLSIYLSIYLSIYLSQTVSYLSIYLSIYLSIYLSISDCSYHIYLSIYLSIYLSIYLSIYLSQSVHIYLSISSICSIYLSHLSIYLSIISIYLSICSVCLSVCLSVCLSVYVDQVSSTILTNLFIYLSISVGSYLSISVGSYLSIYLSIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DQ95</accession>
    <name>A0A812DQ95_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_58416</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003993">
        <property type="protein sequence ID" value="CAE1306144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DQ95"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1306144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="264" mass="30808" checksum="CA3FC91989EF3789" modified="2021-09-29" version="1">MSNSSFFSFPPSLVLSPHFPLSLSFSSPPQKIISVERNNIRFYLSVVLSISFYIYIYLSIYLSISNNIYLSISVSFHLFIYLSIIYISIIYLKGFNYLLRYLSYYLLVCLSYFSGSIYLSIYLSIYLLSIYLSIYLSISLSRSVSQSDYLSISLSIYLSIYLLVCLYLLIILFVIIYLSIYLSIYLLVCLYLLIILFVIIYLSIYLSIYLSISLFVIIYQSVLSIYLSYLSIYLSIYLSIYLLVCSYISIYLLVCSYISIYEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DQC8</accession>
    <name>A0A812DQC8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_58302</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003973">
        <property type="protein sequence ID" value="CAE1305946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DQC8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1305946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="171" mass="20778" checksum="8B72E48F30CB7B82" modified="2021-09-29" version="1">MSVCLGFSTVLFLSFFLSFFLLLEDSFYFSNSFYMKIASFSAFPDLSANISSPPPHFHYFFPFLWLLTPFLHFLFPVFLFRVVFFFTFYFSFFLSFFLSFFLSFFLSIFFFFLLFCFFFVSHLYFYASFTFLSRFSFFFLSLFLLCILISSFSSALYILYTFHLIFFFFPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DUM9</accession>
    <name>A0A812DUM9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_61900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004391">
        <property type="protein sequence ID" value="CAE1310172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DUM9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="350"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="398"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="435"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="461"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="497"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="534"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="562"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="593"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="621"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="660"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="692"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="724"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1310172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="752" mass="89869" checksum="B398A537C640C8E3" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DWE4</accession>
    <name>A0A812DWE4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ZYG11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_59816</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004146">
        <property type="protein sequence ID" value="CAE1307770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DWE4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="308"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1307770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="357" mass="41438" checksum="0AC4560016D129AC" modified="2021-09-29" version="1">MSWPQSWPQSWVGGSPYSLLEEFINFLTFFLFKNCTFPFPLSFSLSLSLSRFPRFPLPSLFLTLFLSFPFSLSLSLSLSLSLSLCFRFCFPFIVCKYSLAKKIPSFFLKIARFPLPSLFLTLSPSLFLFLSLSLSLSLSLSLSSSDSLPLSLSLSLSLSFSLSLSLSLSLYLSFFLSLSLLQTLIVYDNLLFSFFLFFSFFFFCSFYLFFFSSLVFLFIFSSFLDFLCFFLFFFLLFSSFFFLIHVFLFFSSPFLLLFFPFYSNILINLPLLFLFLFIFQPSFLFYCFSSSSLSIPFHSLSSVRHSHLFLSFLFFYPIPLLPYFLSPFFLSDFSFLPGNTSHFALDMSVFVTTSLNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E0K3</accession>
    <name>A0A812E0K3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_63714</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004573">
        <property type="protein sequence ID" value="CAE1312451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E0K3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1312451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="240" mass="28561" checksum="0FD5FBF053C882B5" modified="2021-09-29" version="1">MFNSYSPLVSSSSSFFFLFLFLFLLLFSSFLLLFSSSFSSSSSFSSFSSFSSFFFFFFFFPLLLFSFFFLYYYYYIIIIIIVVLSFPCIFSSLLLSVHLIYHSFCYFLAYFHFLFYLIYSGYLYLSIYLSIYLSIYLSIYFLTDLAYLFLCLFVSVGKVSIYLSIYLSIYLSIYLSIYLSSVCYNLSLFMTPSHYIKTCFFSFSPYRSFFSPSLSQHLYSFFLSFFLSFFLSFFLSFCGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E1Z9</accession>
    <name>A0A812E1Z9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_63195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004531">
        <property type="protein sequence ID" value="CAE1311867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E1Z9"/>
    <dbReference type="OrthoDB" id="6161790at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1311867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="184" mass="21186" checksum="A4DAE9B309A94F5D" modified="2021-09-29" version="1">MLQHLSIYLSIYLSMCLRYLMFLAIYLSIYLSVCLSQFVHIYHSMFINLSISAYSSTYVSIFLFIAASSSSLFIYLSQFVHIYLSIFIYLSIYLSIYLSIYLSIPASSRKLGTAEDGCGMEENFSSIYLSIYLSRAAFLSIYLCKSVHISLSSIFHIYLSIYLSISVCSFYLSQSLHISIYQHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E384</accession>
    <name>A0A812E384_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PPP6C</fullName>
            <ecNumber evidence="2">3.1.3.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_63869</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="2"/>
    <dbReference type="EMBL" id="CAHIKZ030004588">
        <property type="protein sequence ID" value="CAE1312629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E384"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="299"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="329"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1312629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="353" mass="44128" checksum="3E7F6B46C415AF4A" modified="2021-09-29" version="1">MADDNVDKWIEIAKECKYLPENDLKKLCDMVCELLLEESNVQPVSTPVIVCGDIHGQFYDLMALFRTAIQHSSIFFLFSFSFFFVFFLLFFFFLSPFFFFLSPFFFFSFSFFFFFSFSFFFVFFLLFFFFSFSFFFCFLSPFFLFSFSFFFLFSFSFFLFSFSFFFFLSPFFFSPFFFFSFFFFFFFLLFFVFFLLFFFSFSFFCFLSPFFFFSFSFFFVFFLLFFLFSFSFFFCFLSPFFFSFFFFLFLSPFFCFLSPFFFFSFFFFFLFFFFLLFFVSFSFFFFFFLLFFFSFSFFFFFFLILFFCFLSHSFFFSLFLILFSLFFSFFFLSFSHSFFSLFLILFSLFFSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E619</accession>
    <name>A0A812E619_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_66962</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004834">
        <property type="protein sequence ID" value="CAE1316200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E619"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1316200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="230" mass="27490" checksum="2B8561C2410A4BFC" modified="2021-09-29" version="1">MLIFFLLFCFFHSFFLFFFFLSFFLSFFLSFFLSFKIFIPFVPENLNASCLVFHAHFLFTFQFLSFFLSFFLSFFLSFFLSFKTSIPFVPENLNASCHVFHAHFRLTFSVFFSFFLSFFLSFFLSFKISIPFVPENLNASGLVFHAPLLLTFPFFSFFLSFFLSFFLSFKILFLLFPFLFVPENLNVSCLVFMLLSSYFSLSFLLSFFFLSFLLSFFLSFFLRFSIPFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E7K1</accession>
    <name>A0A812E7K1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_69346</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005072">
        <property type="protein sequence ID" value="CAE1318892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E7K1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1318892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="157" mass="17886" checksum="8A128D880020B61E" modified="2021-09-29" version="1">MLCSFFQKCSFPSITFSTILPLSLSLSLSLSLFFSFSFSLALPLSFALSLCVCVCLSDTFSCLLSMSRNCKVEQFDSRVVHSFFLSFFFLILFSFRFPNVVSFSLSVFLFLSFFLSFLLYFFSSSFFLLILSISHLLFLLLFLLFFFFRLCAGASGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E8M2</accession>
    <name>A0A812E8M2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RBM25</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_66719</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004817">
        <property type="protein sequence ID" value="CAE1315896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E8M2"/>
    <dbReference type="OrthoDB" id="8963674at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="373"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="400"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="427"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="454"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="484"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1315896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="558" mass="63630" checksum="914368A33867BE79" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E8P4</accession>
    <name>A0A812E8P4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_70120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005126">
        <property type="protein sequence ID" value="CAE1319821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E8P4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="312"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1319821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="336" mass="39279" checksum="B58A2891C768C4B1" modified="2021-09-29" version="1">MKKKKKKEIYHCRFFLSIYLSIYLSIYLSIYLSISVLLSISIYLDSYLSIYPSQFFMLSYSRRKSQHQLPAFGCFPHQPLFSFFFSFLVLKRFLRTILKKFFSICLTGRRVVISSLIPFIPSQIHSRDHSSNILSLLYFFLHSILEPCPFISNMVERRPNPASFILLIRTIPSVFDHVFSFTVVFPQFLIFFFLYFFLSFFLSFFLSFFLSFSSLHCINIFITYSGITLPRLTSPNLLSTSAIDQVVLIHLTFSISKDSRRVCLCTHALSCTNGCVANRVFTLFSLTYLSIYLSIYLSIYLSIYVKSVKKKIFYLSIYLSIYLSIYLSIYLSISVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EB50</accession>
    <name>A0A812EB50_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rhodopsin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">SPHA_69033</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="25">Farmed</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21">Photoreceptor required for image-forming vision at low light intensity. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G-proteins. Signaling mediates the activation of phospholipase C. Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by arrestin and terminates signaling.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="20">Cell projection</location>
            <location evidence="20">Rhabdomere membrane</location>
            <topology evidence="20">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="22">Membrane</location>
            <topology evidence="22">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="22">Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005053">
        <property type="protein sequence ID" value="CAE1318583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EB50"/>
    <dbReference type="OrthoDB" id="9996086at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009881">
        <property type="term" value="F:photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007602">
        <property type="term" value="P:phototransduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007601">
        <property type="term" value="P:visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15337">
        <property type="entry name" value="7tmA_Opsin_Gq_invertebrates"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000044">
        <property type="entry name" value="Opsin, ultraviolet-sensitive"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050125">
        <property type="entry name" value="GPCR_opsins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001760">
        <property type="entry name" value="Opsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027430">
        <property type="entry name" value="Retinal_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006031">
        <property type="entry name" value="XYPPX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24240">
        <property type="entry name" value="OPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02162">
        <property type="entry name" value="XYPPX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00238">
        <property type="entry name" value="OPSIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00239">
        <property type="entry name" value="RHODOPSNTAIL"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00238">
        <property type="entry name" value="OPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="17" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9 22" id="KW-0157">Chromophore</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10 22" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="18" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0564">Palmitate</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="3 22" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="14 22" id="KW-0675">Receptor</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 22" id="KW-0681">Retinal protein</keyword>
    <keyword evidence="5 22" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="16 22" id="KW-0807">Transducer</keyword>
    <keyword evidence="6 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 22" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="19" id="KW-0844">Vision</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="32"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="152"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="199"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="24">
        <location>
            <begin position="51"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="346"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="380"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="380"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="23">
        <location>
            <begin position="393"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00043946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00045936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU004951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="CAE1318583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="449" mass="50093" checksum="C7EF1F30F67FF2C0" modified="2021-09-29" version="1">MGRDIPDNETWWYNPTMEVHPHWKQFDQVPDAVYYALGIFIGICGIVGCGGNGIVIYLFTKTKSLQTPANMFIINLAFSDFTFSLVNGFPLMTISCFIKKWVFGNAACKVYGFIGGIFGLMSIMTMAMISIDRYNVIGRPMAASKKMSHRRAFLMIIFVWMWSTLWSIGPIFGWGAYVLEGVLCNCSFDYITRDYTTRSNIVCMYIFAFCFPILMIFFCYFNIVMSVSNHEKEMAAMAKRLNAKELRKAQAGANAEMRLAKISIVIVSQFLLSWSPYAVVALLAQFGPIEWVTPYAAQLPVMFAKASAIHNPLIYSVSHPKFREAIAENFPWIIACCRFDEKEVEDEKDAEAEIPATEQSGGGGGESVDAAQMKEMMAMMQKMQQQQAAYPPQGYPPPQGYPPQGYPPPPQGYPPPPPQGYPPQGYPPPQGAPPQAAPPQGVDNQAYQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EEI1</accession>
    <name>A0A812EEI1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_70827</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005183">
        <property type="protein sequence ID" value="CAE1320596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EEI1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1320596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="240" mass="27486" checksum="28F7D4A3E85DDFEB" modified="2021-09-29" version="1">MEVQSEGSRGRIYSAFVSGSCQIITVHGSSVRREQRPNIQCICQIITVHGSSVRREQRPNIICQIQFMKFRKGAEAEYTVHLSNHNSSWKFSQKEQRPNIQCICQIITVHGSSVRRGAEAEYTVHLSNHNSSWKFSQKGAEAEYTEAVNITVHFSQKGARPNITVQMEQFSQRREQRPNIQCICQIITVHGSSVRRSRGRIYSAFHGSSRREQRPNIQCIKWEVQSEGSRGRIYSAFVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EEI6</accession>
    <name>A0A812EEI6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">OLFR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_72118</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005296">
        <property type="protein sequence ID" value="CAE1322116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EEI6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1322116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="201" mass="23610" checksum="A8988F7281ED4466" modified="2021-09-29" version="1">MTPKLKKLFLAHSLSLNVFVFFISLFPFFLPFKQIFISFLVIATFFSSFQPHGSFFTLQFHISFFLFYLSPASSCFCCNVIYLSFLSHLILLHPHLSSFLCNLIIFLPFLATSFPCSLIFLFDVISLFLDFFLSFFVTASFFFSFFLTLSFFFLSLHLSFFLFSFFSAAYFFLFSFKPIFLSFFLSFFLSFFPICLFCSAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EEM7</accession>
    <name>A0A812EEM7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_72979</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005353">
        <property type="protein sequence ID" value="CAE1323086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EEM7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1323086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="181" mass="20437" checksum="32C5325E594E1E08" modified="2021-09-29" version="1">MTLPLPLTLSIAEVEEDPSPLGVFSYCLSFSFCRLGTWPAIKQKMCSLSLSCCIAAFLLEVVCSFFLSVPFCPLFKGLVTVETAFFLLLLGVTSFEIFSSALSFSHKYFLLRSFLTFFFSFSINCLLSLFHPDVTAIHIRHQTGPSIPLGDEFSSQPREHIFSAHMPRQVLHMDKFCEHVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EEQ3</accession>
    <name>A0A812EEQ3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SPHA_72302</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005305">
        <property type="protein sequence ID" value="CAE1322265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005798">
        <property type="entry name" value="Cyt_b/b6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039715">
        <property type="entry name" value="ZCCHC10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13491">
        <property type="entry name" value="ZCCHC10 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13491:SF0">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51003">
        <property type="entry name" value="CYTB_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="240"/>
            <end position="260"/>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005410">
        <property type="protein sequence ID" value="CAE1324472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EGX4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="307"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="392"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1324472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="437" mass="49451" checksum="89C7F90CDF7ACFA3" modified="2021-09-29" version="1">MSLSAFLFQILLLLSHLYHYSLSLSLSLFLLLHNSGYLSLDLSFFLSFSLCILYPVSLSLSLCLSLFLSLSFSFLPSLSLFVSFNLFLFLSVSFSKTLSFYLTFSPCILYSISLFLFLLLFESLALSLSLILCLYLTYSLCILYSVSLFFFLSHSLSLSLTLFLSVSFILSLILFFVSLPLFLSLLLFLSLSLFLCLSVFISLSLSLTVSLSLTLSLSPVLSLFLSLYPFHCLSFISLSVFLFVDLSLSLSLSDCLFLYIYIYIYIYILCLSAFFLLCLSLFFSLSLCLCLSFSFSLSLFLSLSVSLSFYFSFSISVAFSIFLYTLLCLLASLFFSVFFFLSLTFVLAFSLFSSLSLHVHFSILTFSFSLSLSLFISLSISFPISPSLPFSLYVYFILYFSFSLCLFFSLFLFLSLYLFLSPSLSLSLYSSLSLFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EH37</accession>
    <name>A0A812EH37_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_72252</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005305">
        <property type="protein sequence ID" value="CAE1322212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EH37"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1322212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="247" mass="29373" checksum="B573FB1457D2FCA1" modified="2021-09-29" version="1">MNIHEPKHVELTPIYLSIYLSIYLSIYLSIYLSMHNCYSKHVELTPIYLSIYLSIYLSIYLSIWNVKTNLFFLSFFLSFFLSFFLSFFLSSFLSFFLSFCAYIPLSILDVHYLSIYLSIYLSIANIFVIFFHLSIYLSIYLSIYLSICEFSFIYIFQKLSYLSIYLSIYLSIYLSIYLLHEKKNSEFYLSIYLSIYLSIYLSIYLSCIHTYSSACLSIYLSIYLSIYLSIYCGIEISIYLSIYLSKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EKE3</accession>
    <name>A0A812EKE3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_75494</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005460">
        <property type="protein sequence ID" value="CAE1325903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EKE3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="337"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1325903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="366" mass="43574" checksum="F605E43DD6D180D6" modified="2021-09-29" version="1">MLNNFFKEFRSFFLSFFLSFFLSFFLSLPFLLSHADINHISIHWDYILTDLLSLLSIYLSIYLSIYLSIYRQSRRHQTISAHKKPERVLRGYDVCGGIKRTYCVTEAVHQWTEEKREIYLSIYLSIYVALISIYLCRFNIYLSIYLSIYLSIYVTLISIYLSIYLSIYLSISLQYLSIYLSIYLSIYLSIYLFLLSISLFSTYLSIYLSIYLSIYLSIYLSLFFIYLSIYLSIYLSIYLSIYLYIKQLLVSLQCRSIYLSIYLFQLLKRTLKITFKLVIYLSIYLSIYLSIYLSMYSNVNKSIYLSIYLSIYLSKLSALCCYSNISLRYSNVNKSIYLSIYLSIYLSIYLTFPLCVLLIRHLIKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EKM1</accession>
    <name>A0A812EKM1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_72609</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005335">
        <property type="protein sequence ID" value="CAE1322662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EKM1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1322662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="202" mass="24359" checksum="29E3A08A456D7A65" modified="2021-09-29" version="1">MLGYLSRSAHFLFTYNYFHRYLTQSLNILVFALIYLSIYLSRPAPLVLAVVNCLATRLHARNKRHISKLNAYLETFSLFLSCFIFSFFYLLMSFTFSFLFLSFFLSFFFFFLSFSPKSVNIFLVLHHFFVCFFLLFLFVSFFPTSIHFIFFDTPFLSFFLSFFLSFFSLLIACFCFFYFRLILFFPEKPLFFPFTFFISFLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EN31</accession>
    <name>A0A812EN31_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_76734</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005496">
        <property type="protein sequence ID" value="CAE1327196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EN31"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1327196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="276" mass="32151" checksum="0ACC69C686F2212B" modified="2021-09-29" version="1">MGAPIEEVADPDVVGCSMQLKQGKRQIRLPSYFLVSVYYLSIYLSIYLSIYLPHLFISIYLSIYLSIYLSISVYLYLLSIFIFLNSVYYLSIYLSIYLSIYFSLLIPACLSVCRSICLSLSVFSYLSIYLSITITSLSTYLSMTIFFICISFFYLYISLIFISIYLSIYLSIYLSIYLNIIFFFSVLPSFSLSIPLYLSTIIFQIAFTSSQPFLTGVFFFSSHFSFHFRFTSFYFYLFFFFCHCLLLVAFNDTPIVTSIAVLQVEYYKLQLQPCNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EQ37</accession>
    <name>A0A812EQ37_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_79951</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005584">
        <property type="protein sequence ID" value="CAE1330666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EQ37"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1330666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="239" mass="28201" checksum="CE036F999B68A50E" modified="2021-09-29" version="1">MPPHRCWSVKHFYILFFRSFFLSLSLSISLSLSLSLYLFLYFSLSLSLSLSLSIYLSIYLSISIVSQARDKHIYLSIYLSIYLSIYLSLSLSLSLSLSLSLYIYIYIYIYIYICCQSMRILSLYFVYLSIYLSIYLSIYLHPIYLSIYLSIYLSIYLSIYLSIYLSQSIHLFLSQARLSVCLSFCFSSLKTEIDFLHHHSRIPYFLFPNRRLRLCVMTQINHFSDDLYLSSLNVLSRPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EQG5</accession>
    <name>A0A812EQG5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_80135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005591">
        <property type="protein sequence ID" value="CAE1330893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EQG5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134:SF22">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134">
        <property type="entry name" value="OS08G0543275 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="326"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="357"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1330893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="379" mass="45965" checksum="176CDDE868D3487A" modified="2021-09-29" version="1">MTYRSWYLSIYISMYVCMYVCTDGWMDACMYVHIYLSIYLSIYLSICLSLCMYVYLFISIYLSKAIHIYLSIYLSIYLNVCLLISIYLSIYLSIYLSIYLSIYLLVKLKFQFSFFFSFFFSFFLQYFTLTVSLLSFLLTSVLLFYFHIFFLFHYIPFFCRHPIFLHFFHFQNIRPLHRKALFTSTSILLFTFPMLFNFRFSFAFFLIAILSIRCVLSSYSIFLTLATSFKSLSSSDLIFILYIKHSSLLLSISVLFIVIHFIFFPLPQLSSFFFSIFRFLFLTLFLFSFFLFLFVFRSFFLYLLTFSFFLFLFLTFSFFYSSFFFLYLSFSISVFLSFSISYFSLFISFFFSFIYSFFLFCILSFFFLFLFFLFFISFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ERD9</accession>
    <name>A0A812ERD9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_80683</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005607">
        <property type="protein sequence ID" value="CAE1331480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ERD9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="380"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="417"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="459"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1331480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="535" mass="60947" checksum="E7CD71B2DFDB34EA" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EUV2</accession>
    <name>A0A812EUV2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_79137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005558">
        <property type="protein sequence ID" value="CAE1329707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EUV2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1329707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="240" mass="29777" checksum="9355E8DB197D8605" modified="2021-09-29" version="1">MIHFFFLAFLFYSILNRYFLFLLFHLHFLIHSVFLYVSLFFSFYFYSFSHSVFFPLLFHSILVHLYIHPFFNFLFRFCALFLSLRFLSFIHFPFIFVYICFQSYSIRVLLMIHSFFDSLYIIFIHSAFYAFIFSFFFYSISILYIFFFLFYSCHLFIQLFFLSYFFIYSIIFFPFYFFHNHSYTFFRLFLNLTLSLSLSLSLSLSLSLSLFHSFFLSPFFSSFLFLFFFLYLSFCYIPYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EVN2</accession>
    <name>A0A812EVN2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_78557</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005544">
        <property type="protein sequence ID" value="CAE1329002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
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    </dbReference>
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        </location>
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            <end position="1288"/>
        </location>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAE1329002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1289" mass="151826" checksum="A1122F25887784D0" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EZU5</accession>
    <name>A0A812EZU5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_80774</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <location>
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            <end position="337"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1331646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="338" mass="39553" checksum="3A98CF85A5146F05" modified="2021-09-29" version="1">MRIYLSIYLSIYLSIYLSIYQPTYLHQPFYYLSTNYNNMKLYGGYLNKSLSLMFKNSFFYSIIVFLNQIQNVHGLLRTRRTDPTSCRAVGKDLRRKLKTPCTWNIVIPSSNKFTGSGHILPSNLISFHFFSILIFCHFFISSILFLVLYNLLYLFSCVLLPSFLPSFLPSFLPSFLPSFLPSFLPSFLPSFLPSFFLSFLPSFLPSFLPSFLPSFFPYFIRFFIFPFFFYSFPISLFSFFYISFFLAIVFFLSFFLSFPVLILNTFSLISDFFLSFFLSFFLSFFLYLLSLSFFSFLLLSYSSGCSSLSLYHTLPLSHFPLSLSLSLSLSLSISHYFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EZV7</accession>
    <name>A0A812EZV7_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pecanex-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SPHA_80206</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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            <taxon>Spiralia</taxon>
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            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the pecanex family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="CAE1330947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="5979286at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="entry name" value="Pecanex"/>
    </dbReference>
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        <property type="entry name" value="Pecanex_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12372">
        <property type="entry name" value="PECANEX"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PECANEX-LIKE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05041">
        <property type="entry name" value="Pecanex_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
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            <end position="61"/>
        </location>
    </feature>
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            <end position="93"/>
        </location>
    </feature>
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            <end position="162"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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        </location>
    </feature>
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        <location>
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            <end position="592"/>
        </location>
    </feature>
    <feature type="domain" description="Pecanex C-terminal" evidence="7">
        <location>
            <begin position="1066"/>
            <end position="1235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAE1330947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1243" mass="140489" checksum="181A4A47230BEF87" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AM87</accession>
    <name>A0A812AM87_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_456</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000007">
        <property type="protein sequence ID" value="CAE1139741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AM87"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1139741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="154" mass="18424" checksum="E61BC84495D98C06" modified="2021-09-29" version="1">MSLCSFLSHFIHIYLSIYLSIYLSIYIYVCMYVSIYLSIYVHIIIICSYLSIYLSIYLSIYLSIYLSKPIHIYVCMYVCMYLSIYLSIYLCSYYYKYICIIIYLSISLFISIYLSIYLSIYLFCSYLSISIYLSIYLSIYLSKNNCPNHPFIFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AQY0</accession>
    <name>A0A812AQY0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_3875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000117">
        <property type="protein sequence ID" value="CAE1153478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AQY0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1153478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="205" mass="24023" checksum="A24ABD20F7A082F9" modified="2021-09-29" version="1">MSSSTSSTSTSGPKDLPGEKEAIYSVGSQTFFSFASQFLSFFLLSIYLSIYLSIYLSIYLSVCLSSSLLLDFFLSFFLSFFLSKYNRFLSFFSFLLCFPLSVIFTLLVLVVLLFFFLFFFFFFVFVFFFFFLFFFFFLRFLFLLLILLFSSFSSSCLIFFLSFLFFSSSFSSSIFIAIFFLSFFLSFFLSFTTPNVVFLFFFGLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AS21</accession>
    <name>A0A812AS21_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MPP5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_4175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000130">
        <property type="protein sequence ID" value="CAE1154394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AS21"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1154394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="307" mass="35886" checksum="AC327B876EF565C0" modified="2021-09-29" version="1">MQEFLSGCSVDNKKKRKILLFHLNITTFSFSLSLSTFSFFSLYLFFFSLSIFSFSLSFYLFSLSTFSFFSLPFLFLSLSLPFLFLSLSTFSFYLSFYLFFLSLHFLSLSLPFLFLSLSTFSSSLSLPFLFFLSLSTFSFSLSTFSFSLSFYLSFLFFLFLSIRFLSLSLATIFFSLSLFSLSLPLLFSLSLSTFSFSLYLFSFFSLYFFFFSLYHFFLFLSLYLFFFLSVSTFSFSLSTFSFFLSVSIFCFSLSLSFLFLSLYIFFFSVSLSTFSFSLSTFFFSLSLSHFFFSLLCLKTSDIHFNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AUX8</accession>
    <name>A0A812AUX8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_7391</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000237">
        <property type="protein sequence ID" value="CAE1162661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AUX8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="332"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="377"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="441"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1162661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="471" mass="56551" checksum="53536151559D3DE9" modified="2021-09-29" version="1">MSIYLSIYLSIYLSIYLSIYLYRERERERISLLPLDTTLFFFATPFPLCSFSSLFFFPPLYLYTYSIFRFSFPIFPLYHLPFPPDHHLISPSIFFCVFFFINLSHAHSRIFFFLSISIIFISRFFSLSFLSCLSRLHPFSLVFAFPPQSFFLSFFLSFFLSFFLSFFLFFNISLFSTSCLAISTSFRLPASYLSLFLYSFLFLPLYYFFYLLFILFLHFIYCLSLPTSPLFYLSLFFYQSLSLTFSLFLSIYISLFFYLFSSFLFLSRYLFLCFPYFSRSSFTIPTFLFLVLRPFLPLFFLFLSTLSLSHITNTLLFPYFSSFFLRLSVYNTLSLSFSFLSHSVYNSLFPFAFFFYILSFLPSPSFSRSSLLKTKSLFFFLSFFLSFFLSFFLHLSIYLSIYLSIYLSIYQRKKDKERKKDKDRDFSEWKRKVQYKALSSTLLFPFAFFFYILSFLPSLLYIIIYNKISVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AWZ3</accession>
    <name>A0A812AWZ3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_5907</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000194">
        <property type="protein sequence ID" value="CAE1159322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AWZ3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1159322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="316" mass="36920" checksum="FAF9241E216559C4" modified="2021-09-29" version="1">MIHFVLFVRSQLSSLHVHPIYLSIYLSIYLSIYLSIYLSSHSVFPCSAILMRVHQYNLSICSFFSLSSFSPLLSHGLSLSLSLSLSTLNSYSFSPSSFSFRFPFSLFVLPSNTKLYFQITIIFPFLLFLLLESYFFLSFFQKLPFLFTLFLQTLTFSSFIYLLFIALTYTFLTFFFFCILPFYLFIITLFPFFFLLSNFFITFFSLNPLAFSFFFFSFSFFRPVSLSLSILFTQPFMISLRMSFFLSFLTLSLTSTYIDYPFSLSLSLSNILFSLSRFSQTQLSPLLLSLSLSLSLSLSLVILFNKQQRKKRCHTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AXX0</accession>
    <name>A0A812AXX0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_6357</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000208">
        <property type="protein sequence ID" value="CAE1160281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AXX0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36912:SF2">
        <property type="entry name" value="ANTIGEN 332, DBL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36912">
        <property type="entry name" value="ANTIGEN 332, DBL-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1160281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="531" mass="55791" checksum="DBF13E8E541EF0A0" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AZP7</accession>
    <name>A0A812AZP7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_7335</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000236">
        <property type="protein sequence ID" value="CAE1162528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AZP7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1162528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="212" mass="24695" checksum="57A1D1DA96BE3EBD" modified="2021-09-29" version="1">MIYLSIYLSIYLSIYLTLTIISLFLSIYLILTSIYLSIYLSIYLSIYLSQFVLLYLSHLFISIYLSIYLSIYSSLFNIYLSIYLSISFTPAYFISIYLFHTRTYTELFRSVSPFLSSRHFLRFVYRSVVHLATRRINLFFIRAIHKITTPVIIRKGQFLLDPPLQSPGDHVMSSPGEEEKRKTSGKPPSVRHSGRCLPDTYDQTVGGRWTNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B111</accession>
    <name>A0A812B111_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="15">PCDHD2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SPHA_9372</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000301">
        <property type="protein sequence ID" value="CAE1167367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B111"/>
    <dbReference type="OrthoDB" id="6252479at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000020">
        <property type="entry name" value="Dachsous cadherin-related 1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000002">
        <property type="entry name" value="Protocadherin alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000007">
        <property type="entry name" value="Protocadherin alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000134">
        <property type="entry name" value="protocadherin Fat 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013164">
        <property type="entry name" value="Cadherin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050174">
        <property type="entry name" value="Protocadherin/Cadherin-CA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028:SF146">
        <property type="entry name" value="CADHERIN 96CB, ISOFORM D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028">
        <property type="entry name" value="CADHERIN-87A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08266">
        <property type="entry name" value="Cadherin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 11" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 13" id="KW-0732">Signal</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032844873" evidence="13">
        <location>
            <begin position="22"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="691"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="28"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="137"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="248"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="362"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="466"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="592"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAE1167367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="843" mass="94341" checksum="635620B48C25002A" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B140</accession>
    <name>A0A812B140_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_8700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000283">
        <property type="protein sequence ID" value="CAE1166063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B140"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1166063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="209" mass="23989" checksum="1E94CD3C07CEC0AF" modified="2021-09-29" version="1">MCSVTTGLQQVPTQINRFFFFFHSLSLSLSLSLSLTLYFIFCGGKLTYACLFIYLSFSLLYPPLSLSLSLSLFIYLSFWSLYPSLFLCLSIYLSLILFIILISLYLSIYLSLILFIIPPLSLSLSLFKYLLFCSLYPPLSIYSSISHSVHYLSLSLSLSIYLSIYLIFSVPCLFLFPSISLCHYLSIYLSIYLSIYLSLCVYKTSIFIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B380</accession>
    <name>A0A812B380_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_10060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000322">
        <property type="protein sequence ID" value="CAE1168464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B380"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1168464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="220" mass="26928" checksum="B808F17E91F8B5E9" modified="2021-09-29" version="1">MLISIYLSMTVHIYLSESFLFYLPINLSLFYLCLFFSFLYLCLFYLFSFCLFFIYPFFFLSIYLSIYLSIYVFSNYIFLPTNLSMTFLFFYLSIYLSIYLCLFTYLCMSFLFILPIYFLCLCFSTYLSLFCFFHLSFYLFMSLLCFLLIYLCLFYVLFYLCFVPTYLCLLPIYLCFLPTYLSIYPFSTYLSMFSIYLPFFYLPIYLYSFIRECIYMSNIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B459</accession>
    <name>A0A812B459_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_10314</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000333">
        <property type="protein sequence ID" value="CAE1168912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B459"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="313"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1168912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="364" mass="42703" checksum="DD42A15161AB2C55" modified="2021-09-29" version="1">MKFPFLSLLKYLHVIDFSLSLFISINLSASVPIYLSIYLSIYLSIYLSIYLILLISITFCSYLSIYRISTYHILLNIYLSIYLSIYLSIYQSLYRDLLISITFCSYLSIAYRIVNILLISIYLSIYLSIYFCSSMLVCSYISMCLNIHLYQFAYIYVCMYVCMYVSIYLSIYHILLTSIYLYQSALYLSIYLSHSAHVYLSISVCYLSIYLSIYLSIYLSHSAHVYLSISVCYLSIYLSIYLSIYLSIYHILLVYLSISVCSLSIYLSIYLSITFCSRLFIYISLLSIYLSIYLSIYHILLTSIYLYQSALYLSIYHILLTSIYLYQSAIYLSIYLSQSAHIYLSIYLCNLLSKYLSLYHYLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B4R2</accession>
    <name>A0A812B4R2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_12896</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000432">
        <property type="protein sequence ID" value="CAE1173987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B4R2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="282"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="312"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="346"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="376"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="486"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="518"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="547"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="575"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="605"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="631"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="658"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="689"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="719"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="750"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="773"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="807"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="840"/>
            <end position="862"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1173987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="892" mass="107776" checksum="79CD1088B0BB3AD0" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B674</accession>
    <name>A0A812B674_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">COL6A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SPHA_10941</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000358">
        <property type="protein sequence ID" value="CAE1170116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B674"/>
    <dbReference type="OrthoDB" id="5985714at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd01450">
        <property type="entry name" value="vWFA_subfamily_ECM"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="collagen alpha-6(VI) chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050525">
        <property type="entry name" value="ECM_Assembly_Org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020:SF20">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00453">
        <property type="entry name" value="VWFADOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032292430" evidence="6">
        <location>
            <begin position="27"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="7">
        <location>
            <begin position="35"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="7">
        <location>
            <begin position="225"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAE1170116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="406" mass="45328" checksum="59F9E38371A15605" modified="2021-09-29" version="1">MFAMLRLFVQVFVCFIIFHFNDVANAKLCSEPATDVIFLVDNSGSLKENEFQTELDFAAKMIMQFNLGPQNYQAGFYTFSTDAQSHIQLGKFTENAALASSIKQIPYVGGFTFLGKSLKTVNQGFSLSAGGRNNVRKALIIISDGNTVDVKVTAESVKLLRDNDVQVYAIVFGSKVDMQLSRSLVAKSSDLFKISKISDLDSVLDGVKKTVCIDEIPVCGVRQMDIVFVLDESFSVELDQFTLLRYFVSRFVRNSKIGPKYAQISIVAFADKVRNVFWLNDYKYKDDVSAQIHQLQRIGGVTYTNLALKHVRMESFKKEHGGRSGAQKVVVVLTDGQSLMPEETLKEARGLHNIGANVFAVGVGHDVSLEELKKVASTEDYVFHVTTFDMLAEIEQEFRMKVCKTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B783</accession>
    <name>A0A812B783_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_14278</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000488">
        <property type="protein sequence ID" value="CAE1176709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B783"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1176709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="202" mass="22575" checksum="DCB937C9DBA539E7" modified="2021-09-29" version="1">MYLHSSGLSLSLSLSIVLFPLFSLSLTHRHTLSIYLSISLSLSLSLSLSLSLSRYFGSLYLSLYCSLPLYCSFSLSLSLFLSLLFSLALDLFFSLSLLLFSLSLFYLYLLLSLSIALSFAIALSLSLSLSLFLSLFLSLSIDFRSRLFSFFPIWTSLALFLLPISSCCYIFFIPVFCLPHISANCKCSWNCSASRSSMDFLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B7F0</accession>
    <name>A0A812B7F0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_12345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000413">
        <property type="protein sequence ID" value="CAE1172939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B7F0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1172939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="236" mass="29028" checksum="76056F7C28DE1722" modified="2021-09-29" version="1">MFSFYFLLFLFLIHSFFIGNFSFHFNFIFFINPFFHFFLFFLSFFSLSYFLFFLLLFIFYHFTSNVSILYHLLSFLHSSFHSYLFFSFLFLFTINFLHLTFPFLFFLELIHLFSFSLISLYSAHSCFLFHLLLLLLSFSFPFLIFHSNQLVSIVFIIYFLCSFYSAFIYFILLYFSFIFFPFSFFHFYVCLILFFFPFFLIFSSFFHSYNLLLSFNPLIVFILTFSFFFSFFLTPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BA29</accession>
    <name>A0A812BA29_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_13043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000435">
        <property type="protein sequence ID" value="CAE1174276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BA29"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1174276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="190" mass="22356" checksum="1B09403E36D439BA" modified="2021-09-29" version="1">MPISIYLSIYLSIYLITFKLRKVFFTLFSCYTPSILSLLPPILFSACTFSLLSSRFFFLLFLLTFHFYSYLHLFFFFSLHLLSIRLFSPYFISVFPSFFSLSFSPDTFFLNPLHLLITQPLFVLCISPPYSPFLLYKSSSLLSLFQQVFTLLYYSSDTYSLLSFLAYFYYSPLSLFLLFYPSLIEATVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BAP6</accession>
    <name>A0A812BAP6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_13904</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000470">
        <property type="protein sequence ID" value="CAE1175985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BAP6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="282"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="384"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1175985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="413" mass="49758" checksum="66FF25460B985EBD" modified="2021-09-29" version="1">MNSFENFFPLSFSRLLFSFFFLLFNVFYFSLFSLFTILSFSQIFYCFLFLFLFFVDFFYLFFPLYSFFLFMCVYIFLSFLLLTLFLSFFLPILLLLFYYFSAIIFFSLSSRYFPTLLLFDILFLSLKFSFCRFFISVLISLLFPRRFSIVFFLSAFFSFFVSFTYFRHFFLDACSPSFIFLSFLFVLSFFLSFFLSFFLSFIHSFFSFFLFVIFLSSFFSRLCIYIFNISFLLLFLCRSHLFIYIFRTFNLHLHFSISYFISYTFLSRSFSCVCHTHLEQNYFYLLCLSFFFYHSRSAFTVFPSIFHSLSHSAFPTRSVFLTFPCYLPHSPSFSVAIFLSFFMMFFRTHQMSKRLDFFLIFALLKSETFITVILYLFLSLTPFSFSFSLTLSLFLSLSFSLSLFLSLSLSLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BBF2</accession>
    <name>A0A812BBF2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_14300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000489">
        <property type="protein sequence ID" value="CAE1176769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BBF2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032951985" evidence="2">
        <location>
            <begin position="18"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="350"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="387"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="413"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1176769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="437" mass="47098" checksum="F2BBDB0E9CCB3673" modified="2021-09-29" version="1">MKLKIISLSFLFSSLTTLPTLSPSVSFADFVSVCLLCRLCLRLSPLPTLSPSVSFADFVSVCLLCRLCLRLSPLPTLSPLPTLSPLPTLSPLPTLSPSVSFADFVSVCLLCRLCLRLSPLPTLSPSVSFADFVSVCLLCRLCPDLPTWVSNVYLPTPVSFFFLSPHSLAFSVSLPCSLTYSPLLSPSFCLLLAFFLPPSLSLSISGFLPPALSLSLSISGSLFLSLRFLPPASLSLSISGFLLPLSLSLSISGFLPPPSLSLSLSISGFLSRPLLSLFLSPLSLSLSLFLAFFLPPSLSLSISGFLPPALSLSLSLFLAFFLPPSLSLSISGFFLRPSLSLYFPPLSLSLYFWLSFSPLYFWLSSSLSLSLYFWLSSSSPISSFLSLSLSGFLPPLSLSLFLAFFLLSLYFSFFSLSLSLSLSLSLSLSLYLSYGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BD51</accession>
    <name>A0A812BD51_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_13465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000452">
        <property type="protein sequence ID" value="CAE1175133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BD51"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1175133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="293" mass="35382" checksum="36EED078F29D36ED" modified="2021-09-29" version="1">MSFIEQDFLQIISSLLYPASFLLFAFHFCFYFLTPILFCFLFFLLSIFHFFFLYFSFFLHFAFFLSFFLFYSRLLILLHYLFFLFLLFTFNFTLCFSFILFTLYLMYLSFNIFFFFKPYLPFSLLFLSFFLLLPSILLFCSFLLLYVQFYYLPFFHSFYSLPPIFSAFHSTIFSAFLSFLSLPILCLSLYSIFNSLCFFRFFHSIFSLLFFLLVFFSILTANFIFSFSFFLSFYSLPFSFSTSFFLTGILFKSVYSYFFPLQFVLYIMNNNGHLLPYFSSGFLVSSSHFPLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BD88</accession>
    <name>A0A812BD88_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_15252</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000529">
        <property type="protein sequence ID" value="CAE1178522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BD88"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1178522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="173" mass="20238" checksum="5A4E5A14290EF810" modified="2021-09-29" version="1">MLRCLNKSDKKRVKPIKCLNLSIYLSIYLSIYLSIDLSQSIHISSSVHLSISSIYLSIYLSIYLSIYLSIYPIHSYIINYLSQSIHLISIYLSIYLSIYLSIYLSPFIYLSIYLSIYLSIYLSHPFIYHYLSIYLSIYLSIYLSIYLIEAEARDSYQLTGNQRSLLTTFLSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BDB0</accession>
    <name>A0A812BDB0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_15311</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000533">
        <property type="protein sequence ID" value="CAE1178636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BDB0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1178636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="161" mass="17978" checksum="866FABB490DD76ED" modified="2021-09-29" version="1">MTYTAQLASSDRAMTYTAQLASSVGTTTYTAQLASSDRAMTYTAQLASSVGTTTYTAQLASSDRAMTYIAQLASSVVTTTYTAQLASSDRAMTYTTTEKIRNGKISIKPFYFYLSIYLSIYLFHSIYLLSIFYLSIYLSIYLSIYLFHSVPIYLSIYLSIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BFG4</accession>
    <name>A0A812BFG4_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Abnormal spindle-like microcephaly-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_17489</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000624">
        <property type="protein sequence ID" value="CAE1229889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BFG4"/>
    <dbReference type="OrthoDB" id="1738954at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.190:FF:000055">
        <property type="entry name" value="Putative microtubule-associated protein futsch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10699:SF11">
        <property type="entry name" value="IGLOO, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10699">
        <property type="entry name" value="NEUROMODULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1229889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="292" mass="33191" checksum="EEEDF01923654C13" modified="2021-09-29" version="1">MLALFLISETGQDPVEECADLEDRFYNNDSFKHGAQADANPFAAETQMEAHASEDVKAPAEEKVTDNVQEETSTNVITNEENISDAATKIQAGFKGYKVRKEMKERKMKSNAATKIQAGFRGHQTRKKLKTMKEGDDQASHPQPLHQQHEQMHRNQQHIHHIHMPNLSTHQPLNPLDENNKKSRGTDIHRAATKIQAQFRGFRARQQMKVMKVKAKAEKALPSVDPEDPRVHEAATKIQAMIRGRKARKEIKVLRLQNKYGHGRHHGHGQAHHTKSSKSHNKDINRVGQHEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BFJ6</accession>
    <name>A0A812BFJ6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_16453</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000579">
        <property type="protein sequence ID" value="CAE1227600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BFJ6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="307"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="358"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="408"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1227600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="429" mass="50977" checksum="591723CEEDB40C90" modified="2021-09-29" version="1">MYIYLSIYLSIYLSISRTFFYLLSLFFFTFFLSISIHSLSLSPFSPYFSLYLFASLFHFSQPLFLTCLILLVLFLWVSCIFTLTFTFSFFISFNLSIYLSIYLSIYLSIYLSIYLSQSVLIYLSLLISIYLSIYLSPHIYLILFLSIYLLFCSCLSHSVHISLILFLSIYISVYLSFCSYLSHSFPISLSINILHCISIYLSIYLVCSCSVDLSTFSMPSSFLFVLLLFFFIFSTFLLFLSSLFLFYRLSSSFFLFFHSFIFLLLFLSNYLTYFSTLSNSFLFLFSFYLPFFCFAVTFFLFLLSLFYFFFFFLPSLIILLFLIIFPNPLSFLLWVFFSLIHFLLLLFFFLLPPKISSHSLYFAFYFFHLLLLLFLRFHFALFLFFTFTFLIFLVFLSFSSSFSLSSLFSFFFIYSLILSFSFPSHILSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BG10</accession>
    <name>A0A812BG10_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SPHA_17841</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000637">
        <property type="protein sequence ID" value="CAE1230667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BG10"/>
    <dbReference type="OrthoDB" id="6148336at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051940">
        <property type="entry name" value="Chitin_bind-dev_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301">
        <property type="entry name" value="CHITIN BINDING PERITROPHIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301:SF0">
        <property type="entry name" value="CHITIN-BINDING TYPE-2 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="7">
        <location>
            <begin position="52"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAE1230667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="243" mass="27306" checksum="8ECB43CEEEC1C9B1" modified="2021-09-29" version="1">MSGRIHPTSLRNNRGEMGLPLYSLLMIFGTSLFLVLSVAGQSTVDVDLDQFCEACVVDTGAGYYQHPLRCDVFVHCAQSGDNRTVMATLKECPSGLYWSQNDLTCRHHYEVNCPQDPCKQPGRIAYREIFSCAGYYICVNGSREVARNCCKDKFRFDEISQKCVPDEICRSSCHSNLVLVTNSDTHVPICTMKAVADDVTVYLQEVHGYFYRMPCPRGTVFSTKACSCVRGRRKKIGGLFQYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BGC0</accession>
    <name>A0A812BGC0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_16218</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000568">
        <property type="protein sequence ID" value="CAE1226916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BGC0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="150"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="202"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="355"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="387"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="449"/>
        </location>
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            <end position="480"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="579"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="716"/>
            <end position="736"/>
        </location>
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        <location>
            <begin position="806"/>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="851"/>
            <end position="870"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="876"/>
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        </location>
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            <begin position="914"/>
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        <location>
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        <location>
            <begin position="1012"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1048"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1077"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1125"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1161"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1234"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1256"/>
            <end position="1277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1226916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1278" mass="149820" checksum="A1297BA6A05CACB9" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BQA6</accession>
    <name>A0A812BQA6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_20946</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000768">
        <property type="protein sequence ID" value="CAE1237760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BQA6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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            <begin position="117"/>
            <end position="142"/>
        </location>
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            <begin position="148"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1237760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="247" mass="27584" checksum="7DC332B0B0A4F5BE" modified="2021-09-29" version="1">MLPLFSSFSSSFSSCSSSSSFSSSFAAAAASSSSSCSSSSFAAAASSSFSSSSSSFSYASYSSSSFSSFFAAAASSTFFSFSSFSSSSSLKHLPFVSFVHIFFPRDSKESYLKKNNYNYLSIYLSIYLSIYLCSVNATVIYLSIYLSIYLSIYLVQSFPILSIYLSIYHFISIDRSKFLHIYLSIYLSIYLSIYLSQFHFMYVSMYLSIYLNVCTNLCAYRFSHYVFQFVPKLQGYLHLKELACEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BTY6</accession>
    <name>A0A812BTY6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_22760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
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            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
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            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000844">
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
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        </location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1241309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="250" mass="30161" checksum="17F0BDCB15FCE5D7" modified="2021-09-29" version="1">MSIEGGSWLDPVVCVVTNLVHLSIFLAFLLLLFFLSHFFFVFFLLFFSLLLLLLLFYSSQPRGYFLVFFFSFVNRPFFFLCHSNLYFSFLECWIFTALIFLAFFFLFFLLSFFLFFFLSFVIYVLTFFLFLSLVFLRNFSFSHALFLFSFEVAPLTLFLCLLSSLPLLYILFFSFLFFSFNFLRILYLFIPFFLSFFLSFFLSFFLSLFLSFFLSFFLLLSYVSFVLNFHSFIFLLLQTFFFSFCLSLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BV82</accession>
    <name>A0A812BV82_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_24619</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000921">
        <property type="protein sequence ID" value="CAE1245165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BV82"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1245165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="161" mass="18955" checksum="8D8ADFC45E177C6C" modified="2021-09-29" version="1">MFILGTDEPLLTSLKMRNYLVILAETRLIFYHFVILSLFIYLSFFNYSQSFSFYRFFFFSFLLFFNFYALSLFSFASSSISSLRLSLFFYFYHPLSLYFSIFSPPFFSLYITLVFLSFYIFSSSLSSSSSPSLLIFLLFPLFLLLSLPSFFLPLLLLSSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BVS5</accession>
    <name>A0A812BVS5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_26321</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001004">
        <property type="protein sequence ID" value="CAE1248879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BVS5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="291"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="336"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="385"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="431"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="510"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1248879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="573" mass="67006" checksum="3A4187410D3C4CA1" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BWJ4</accession>
    <name>A0A812BWJ4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_24048</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000891">
        <property type="protein sequence ID" value="CAE1243829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BWJ4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1243829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="291" mass="35076" checksum="AC8B01C39E866E86" modified="2021-09-29" version="1">MKKIFIIIKVVLCFFFFSFSTSFFFFVYFFSFFNMIFTHSLLTILFTSFFFFLLPPTTLLLFLLPLTTNISDQTSFFFQYSLLFYYSSYLFIFFILFFFFFFFFFFFIIIIHFFFFFKFFLFLSFLLPPLTPPPLPLLIQASFFALLLPVFFFFFFFFFFFFFFFFFFFFFFKFFPYRLPPPTLLQASYFSSSSSYSSFLIVQASYFPSPLSSSSSSSTSSSFFFFFLLLLLHIFFFKLLFLLRLLTPPARLLFLPLPLQAFSFSSSPSLVVLLLFLIQLLLFSSMSEFQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BXD1</accession>
    <name>A0A812BXD1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_24694</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000925">
        <property type="protein sequence ID" value="CAE1245355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BXD1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        </location>
    </feature>
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        <location>
            <begin position="467"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="524"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="561"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1245355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="611" mass="74636" checksum="A47AC60B7030E0F9" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BYR1</accession>
    <name>A0A812BYR1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_25239</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000954">
        <property type="protein sequence ID" value="CAE1246596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BYR1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="301"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1246596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="366" mass="42986" checksum="3E197C9456EBD3D4" modified="2021-09-29" version="1">MGDGGGMTNFNWNVTGIVSKSDEYTFCLSVCLFSNYVLSLFHLRSHLFLLVISLAFSLIFFFYSSSLTFLSLSSIFFFSLYSSNFFLCRLLDFHMLFLSFPFSLSSSLSILLLLWPAPFSLSLLLIFLSLFFSRILSFFPSFLFSFHFHSFFLCLFFLFFLSLSSFLFFFLPILWSFSLYLLFSVPFLTPHTHCLFVCLFVCLFVSFFLSFFLSFFLHFSLSLFLPILSAFFFSLSPPLSYSPNFVVSLFHLITHFFLWLPTFFSHSFFLLHPPPPLTQFFSLQIFLAILYLYIFVSYSHYLTFTLTLIVCLSHSPFSFFLFLQILSPFFLQKSLFVFLSVSQNYFLSFCISFSIFFSIYFFGFHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C0Q7</accession>
    <name>A0A812C0Q7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_27286</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001052">
        <property type="protein sequence ID" value="CAE1250826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C0Q7"/>
    <dbReference type="OrthoDB" id="6425635at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="73"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1250826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="281" mass="31026" checksum="EB79AAE2D5531ADD" modified="2021-09-29" version="1">MRINLFVTSCPHSCVQPESASRYRDRCKPIALPSLTFYCFGCHLKRRKLLGRRTAAVSAARAARASETPEQTSLRLSRMASRSASRLSTENDGAQTERLASAASTMSARCARLSVEERSFQNSQDAVRVARVEGFTVPSTENPSSFAGSHRQSLLQGFRNTRASVASRASEQPQETAHRRFRNAQSTASARALESPAQTTVRRVRNARSTESARALESPARTTVRRVRNARSTAPARVLECPGQTTVRRVRNARSTASARAAENSEVCRQRLENISNFELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C3Z0</accession>
    <name>A0A812C3Z0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_29118</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001155">
        <property type="protein sequence ID" value="CAE1254712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C3Z0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1254712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="291" mass="34663" checksum="5DBF86FE79430A5C" modified="2021-09-29" version="1">MSYLLALKLSFFFLLSFSLSPFNFYSGFPIGLHFFLSSFLHFFLSSSLSFSHYIFFISFLLHHFLSFSISFFRSFFLPPFLPFYLSFFLPSFIHFFLSSSLPFFLPPFLSPFLPSFLPSFLPSFLPFFLFLSLVLFPLLPFTFILFFLHASLLHTLSLSDPIFLHSFNKPPFFSLLARHSLTHSLSFFYLLSSSLLSLQKKRKDNNRLFFFLQIPPFLSSSFFPFFLSFFFSFFFLFPFILSFFFLSFFLSFFYFPSFFLYFPFFVSFSFLFFPFFLSFFLSIDPDSICDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C5I2</accession>
    <name>A0A812C5I2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_28689</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001125">
        <property type="protein sequence ID" value="CAE1253926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C5I2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1253926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="220" mass="24614" checksum="A82214F7182848B8" modified="2021-09-29" version="1">MSQLYSFKAVEDSFQQPNNNASETTSFMSFQQLYSFKAVEDSFQQPNGNASETTSCPSFYSFKAVEDSFQQQMVMLQRRLHVPTLFLQGCSGCKDSFQQPNNNASETTSCSFKALFFKTVPAVEDSFQQPNNNASETTSCPSFIPSRLFPFSNQMVMPSRAVEDSFQQPNNNASETTSCPSALATKFFRDDFKVVEDSFQQPNNNASETTSCSSFIPSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C7G9</accession>
    <name>A0A812C7G9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_32638</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001360">
        <property type="protein sequence ID" value="CAE1261285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C7G9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1261285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="272" mass="32209" checksum="20CA6AF5B99A821E" modified="2021-09-29" version="1">MLKVPSTAKQRIQVETLTFCINNRRLVYSFPDIIEVYTEKKNGGVFEGMSSVRHLFLSLYLTFYFSNFRYLSIYLSIYLCHSVQICLILFISIYLSISCLTTSIYFIYLLLFIYFYLSIYLSIYLSISLFKSVLFCSYLSTYLSIYLLFYSTYCIPPSHEFFYRFMRVWEGGGKNSPATDCGIDSFKIALIFFTFFSVVLFLHHSSCSFSIYLLFALNSFFFPFLFHFHSLSFFLYCFFLICFFPSSMSLLFLPITSLDFFFSFFFHLSFQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C895</accession>
    <name>A0A812C895_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_30209</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001213">
        <property type="protein sequence ID" value="CAE1256432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C895"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="281"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="313"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1256432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="357" mass="43005" checksum="0AAB5306C8AE3732" modified="2021-09-29" version="1">MYVSIYLCKIYDWKYYLNWLPPQRQANSVYLNPWLEEDLSIYLSIYLSIYLSILMFSILCYSLSLSLHLPPPLHLSLISFYLSIYLSIAVNFFIYISVCSYLFHYVPYLSIYLSIYLSIYLILFTKCHIYLSIYLSIYLSIYLSLFISIYLSIYDRKYYLNCNSSKKIYLSIYLSIYLSIYLCQSFHIYLSIYLSIYHSCFTLSLSISLLSIYLSIYLSIYLSIYLSIYLSNLFLSFFLSHSLFLTMHLYLSICTLFAIFFCPSCLLYVLCVSNSARFLSFFFLSFFPFSFFLSFFPFPFFLSFFFFFPFSFFLSFFLFSFHFLSFFLSFFFSFFLSFFLMRPQNFNSVSFFCFYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C9Q5</accession>
    <name>A0A812C9Q5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_32010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001329">
        <property type="protein sequence ID" value="CAE1260095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C9Q5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="333"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="364"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="448"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="478"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="503"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1260095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="538" mass="62980" checksum="561C55716D28F83F" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CA29</accession>
    <name>A0A812CA29_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">RAB11FIP3_4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SPHA_30482</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cleavage furrow</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Midbody</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Recycling endosome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001224">
        <property type="protein sequence ID" value="CAE1256916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CA29"/>
    <dbReference type="OrthoDB" id="418358at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032154">
        <property type="term" value="C:cleavage furrow"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055038">
        <property type="term" value="C:recycling endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032465">
        <property type="term" value="P:regulation of cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037245">
        <property type="entry name" value="FIP-RBD_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019018">
        <property type="entry name" value="Rab-bd_FIP-RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057316">
        <property type="entry name" value="Rab11-FIP3/4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051977">
        <property type="entry name" value="Rab11-interacting_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15726:SF7">
        <property type="entry name" value="NUCLEAR FALLOUT, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15726">
        <property type="entry name" value="RAB11-FAMILY INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25450">
        <property type="entry name" value="Rab11-FIP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09457">
        <property type="entry name" value="RBD-FIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144270">
        <property type="entry name" value="Eferin C-derminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51511">
        <property type="entry name" value="FIP_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0967">Endosome</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FIP-RBD" evidence="10">
        <location>
            <begin position="181"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="45"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAE1256916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="244" mass="29225" checksum="D7211504E1AC8B28" modified="2021-09-29" version="1">MEIRSDEQVKDEQKKHKEYVSRQDRDKAEQLIYLSHRLQDVDRHYEASKEEAIRLKTEIEKLKAEKLELHDKLSETQYSYATLLDDHEKQQNQMLTQAQDFEQERQATAQLLDELGKELEDLRRYKIETEHIRKTQQKNATELPDKCRELEDEVQKLREENRNLRDSNDDLNVQLLSRCMEEGRRLLKYNGAISLADEIDHLTKEELMEALKEQQDVNDRLKKYVDKIILKILEKNPSLLEINH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CAX8</accession>
    <name>A0A812CAX8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_32695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001366">
        <property type="protein sequence ID" value="CAE1261394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CAX8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1261394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="171" mass="20682" checksum="F736A97DE33265DB" modified="2021-09-29" version="1">MLKISQNRNDISGDETRQQILLYFFFFFFFFFFFFFFFFFFFFRLRSFAKFPFYLFPFIYFSSKRSQSTLISLFISIYTCLVSKPLIQRPVFLKKKTYSITNKHYLSIYLSIYLSIYLSIYPYVQVSSYLSVPLCSYLSIYLSIYLSIYLSINNGDTKIKNAWLLSVSRPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CFP5</accession>
    <name>A0A812CFP5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_34448</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001461">
        <property type="protein sequence ID" value="CAE1264945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CFP5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="309"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="337"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1264945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="359" mass="42989" checksum="A6862F36747AAC17" modified="2021-09-29" version="1">MSLFISIYLSSIYLYIYLVQFIHLSIYSSILSIYSSIYDLFISIYLSIYLSIYSSYIQFYSYLSIYLSIYLSIYLSIYLSICDSVCIYLLKSIYQSMSSYIYISILYIHLSIYIIHNLFYLSIYYIYLSIYLSIYLSLSAHVYLSIYLSISNLSIYLALCLSVHIYPSIHQSVSIYLSVHIYVFISIHLSIYLSISICSYLSIYLSIYLSILLIYLSIYLSIYLFFYHFTSIYESILSIYLSIVSYLSIYLLSMFISIYFHICYLSILHYLSISIYDIYIYLSFIYLYRFHLSFFFRHIYLISIKSIYLSIYLFIYLFYLSIYLINCYLFISMCSYLSIYLSIYLSIYLNVINCLYGFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CFW7</accession>
    <name>A0A812CFW7_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5641 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_34088</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001441">
        <property type="protein sequence ID" value="CAE1264214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CFW7"/>
    <dbReference type="OrthoDB" id="6145901at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040676">
        <property type="entry name" value="DUF5641"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF2">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18701">
        <property type="entry name" value="DUF5641"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5641" evidence="1">
        <location>
            <begin position="106"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1264214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="177" mass="20018" checksum="8AA3AF4A11365A93" modified="2021-09-29" version="1">MLLQHGCTKLTRELLTTFLVEVAAIVNNRPLVPVSTDTEDPVLLTPSTLLTQKISSVPAPKGDFTTKDVSRRQWRHVQHLAQRFLNLVEGPVPPSFAGLMQMDFQHSKPGSVVLLKDQDSKRNEWPLGLVTRIIPSRDGRVRQVEKKIHENDRAKLFLRHVTETVLLLPRLPSEPIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CK21</accession>
    <name>A0A812CK21_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_36816</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001619">
        <property type="protein sequence ID" value="CAE1269927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CK21"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1269927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="163" mass="19731" checksum="D47840E43BE03020" modified="2021-09-29" version="1">MKDNANERLKTYFYSYLNSSSFLCFYLSIHPYFLLSSSSFFIFILPFFSLFIHSYFLLSPVIRSFFLLFPFHLSFLFSFPFSFVLPFFFSFSFVLPFFFFSFSFVLPFFFFSFSFVLPFFFLSPFHLSFLSSFQFYLFNNFISFSLLFIQLPCPYVKINFLPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CKL1</accession>
    <name>A0A812CKL1_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Carbonic anhydrase</fullName>
            <ecNumber evidence="3 9">4.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SPHA_38887</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Farmed</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Reversible hydration of carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the alpha-carbonic anhydrase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="3 9"/>
    <dbReference type="EMBL" id="CAHIKZ030001785">
        <property type="protein sequence ID" value="CAE1274442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CKL1"/>
    <dbReference type="OrthoDB" id="429145at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.200.10:FF:000003">
        <property type="entry name" value="Carbonic anhydrase 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.200.10">
        <property type="entry name" value="Alpha carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001148">
        <property type="entry name" value="CA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036398">
        <property type="entry name" value="CA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023561">
        <property type="entry name" value="Carbonic_anhydrase_a-class"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018338">
        <property type="entry name" value="Carbonic_anhydrase_a-class_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952:SF265">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00194">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01057">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51069">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00162">
        <property type="entry name" value="ALPHA_CA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51144">
        <property type="entry name" value="ALPHA_CA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033093903" description="Carbonic anhydrase" evidence="9">
        <location>
            <begin position="19"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-carbonic anhydrase" evidence="10">
        <location>
            <begin position="19"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAE1274442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="334" mass="35432" checksum="8E399E3585D81C05" modified="2021-09-29" version="1">MTVTHIVLALTFFVTVHAADWGYDDPMNWGKSFPSCNGKAQSPVHIKASNAKYVSNLGKIDLTGYKTKTNYDIVNNGHTIQLNIGYRATAKNGGLPGVYKALQFHFHWSHNQNGEGSEHILNNKAYPLEVHIVHMNEKYPNVTEALKHKDGLAVLGFFFEVGNENPAMNKFLNNLPQAGNTAQSGAFSIEEMLGSLDHLDHYFRYLGSLTTPPCSEAVVWTLFSKIITLSSKQLDAFWTVKDSHGQLGKNFRPIQPLNGRQIYVSWSSGQFSVVMNAATAAAATAAAATAAAATAAAAATTAVATAAAATAAAATAAAAATTAAATAAAALKTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CLH8</accession>
    <name>A0A812CLH8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_38114</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001724">
        <property type="protein sequence ID" value="CAE1273391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CLH8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1273391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="203" mass="23861" checksum="DFDFD697A5D5E96D" modified="2021-09-29" version="1">MYHSLPIYLSIYLSIYLSIYLSIYLNSSLKCSKDFRNLNRFLFFFLSLCIYLSIYLSIYLSVFSYLFFCKVFRLFFFSLSKWSRYRFFSFSLTFLLSFLSFFFLAFFFLNFVMSSFFLSFFLSFFLSFTLLSFISSSFLFFFSFFFVLHSSFFLSFFLPRNGFTIDVTSSINSSSSSSSSSSSSSSCPSFLSSLSKFYSLSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CLS4</accession>
    <name>A0A812CLS4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_37159</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001649">
        <property type="protein sequence ID" value="CAE1271268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CLS4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1271268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="224" mass="26831" checksum="CCA38B4058A76717" modified="2021-09-29" version="1">MCVTVFSYLYIIVFSYLYLSIYLSFSYLSIYHLYHSSIYLAIIVFFMSTVFHIYLSITLASYHCLFMCVTVFSYLSIYHCLFISSNLFHVSLFSYLSIYHSISIYLSIYLFFHIYIIYLAIICLLYLSIYLYLSFHIYLSSCLFSYLSIYLSFYLSIYLSIYLSIYLSIYLSIYLSIYLPLFPYLFISIFHIYLSFFLSIYLSIYLSIYLSIIVFSYLSIFLVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CR78</accession>
    <name>A0A812CR78_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_38574</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001757">
        <property type="protein sequence ID" value="CAE1274022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CR78"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="282"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1274022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="301" mass="33330" checksum="50C5CE508D8F9252" modified="2021-09-29" version="1">MLVYLSFSALLSKSFSLHCISVYLSFTALLSLTFCMCVYICLTHSVFLYVFLRLSLSACICMYVGMYVYLSLFYSLRLSVYLSFSALLSLFLYICLSLPLSLSLSLFLYICLSLPYSLSLSVYLSFSVLLSLSLSVYLSFSVLLSLSLSIYLSFSALLSLSFCISVFLCLTLSLSFCISVFLCLTLSLSFCISLFFCLTLSLSLSVYLSFSASLSLSLFLYICLSLPLSLSVCLSFSSYSLSLSVCLSLSDSLSLTLSVYLSFSALISISLSHFLISLALSFSLVLSLSIYLSIYLSFYLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CRF2</accession>
    <name>A0A812CRF2_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondria-eating protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Spermatogenesis-associated protein 18</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SPHA_43467</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MIEAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002185">
        <property type="protein sequence ID" value="CAE1282465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CRF2"/>
    <dbReference type="OrthoDB" id="6047381at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035694">
        <property type="term" value="P:mitochondrial protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035695">
        <property type="term" value="P:mitophagy by internal vacuole formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026169">
        <property type="entry name" value="MIEAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031981">
        <property type="entry name" value="MIEAP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21771:SF1">
        <property type="entry name" value="MITOCHONDRIA-EATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21771">
        <property type="entry name" value="MITOCHONDRIA-EATING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16026">
        <property type="entry name" value="MIEAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mitochondria-eating protein C-terminal" evidence="13">
        <location>
            <begin position="377"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF16026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAE1282465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="577" mass="65603" checksum="3A0D8B02AED18BCC" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CSX7</accession>
    <name>A0A812CSX7_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SPHA_39581</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001849">
        <property type="protein sequence ID" value="CAE1275634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CSX7"/>
    <dbReference type="OrthoDB" id="4187154at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005542">
        <property type="entry name" value="PBX_PBC_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03792">
        <property type="entry name" value="PBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51978">
        <property type="entry name" value="PBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PBC" evidence="3">
        <location>
            <begin position="53"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAE1275634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="317" mass="35568" checksum="171F992128235EBF" modified="2021-09-29" version="1">MDDGQRLMHPQQAGGGPVSMSGAMPPQHGYLPPPGAGGGGGGGGGGGGDEQEQRKQEISDILQQIMTITDQSLDEAQARKHTLNCHRMKPALFSVLCEIKEKTAPLAPFSFHSFFSSPPLPRFLSFLFFSFLTAPRPFHSLKQPPPPVFFHSLSNVPPAPFSFIPYRLLIPAPFSFIPSSLIDDPRNFIPSSYSPPPKEPFIPSSLPPLPHFVSFLLLIFPPQELSFPPLVFFHSFLLDRETDSLYLSISSSRVSLREFLSLIFLPKKYSVFCFHSFFLPLRFLSFFLLVCPPPRFKLPCLPFFFFKKMKNIEPNEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CTQ2</accession>
    <name>A0A812CTQ2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_39764</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001868">
        <property type="protein sequence ID" value="CAE1276036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CTQ2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1276036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="291" mass="33774" checksum="ED34CB8658633A59" modified="2021-09-29" version="1">MSIDITLHLNISVNLYLSIYLSIYLSVSLSISIFSSIYLIYLSLYHLARSFNYLSIYLSIYLSRFFSSYIYLLFFDFSSSISVFSLSIYLSNYLSIYRFNIYLSICLSIYLGLFIICLSVYLSFFLIYLSIYLSIYLSIYLSISVVSISMYLSLYVSILLFHYMPNCLSRFFPYLSIYLSIYLSISVFSLSIYLSIYLSIYLGLFIIYLSIYLSISVFSISIYLSVCLSIYLALFIICLSRVFPYLSICLGRFNIYLSFYLGLFIIYFSLSLSLSLSLSLSFSLSLSLSTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CVR3</accession>
    <name>A0A812CVR3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_44075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002236">
        <property type="protein sequence ID" value="CAE1283496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CVR3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="362"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="398"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="426"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="463"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="493"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="521"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1283496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="555" mass="66020" checksum="34D439A35A2BE140" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CXD9</accession>
    <name>A0A812CXD9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_41871</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002024">
        <property type="protein sequence ID" value="CAE1279704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CXD9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1279704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="270" mass="31892" checksum="6A393810C638C553" modified="2021-09-29" version="1">MLKFDSAALSIYLSIYLSPYIYLFCSYLSIYLCTSLSLSLSLYLSISLSHPVPIYLSISACSYLSIYLSMYISLSLSIYLSIPSCSYLFIYISLFISIYLSIYLSIYLSIYHLSLSILYIYIYIYIYIYIYVFILVLQSIYIYHPLSLSLLFISIYLSIYLSLSIYISFYHTCSYLSIYLSIYLSIYLSIYLSQHLYINLSHPTLYLSIYLSIYLSIYLSMILYLSIYLSIYLRLYIYLSIYLSIYLSICPLIHLKLYLFLSIYLSIYLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CXP7</accession>
    <name>A0A812CXP7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SARS</fullName>
            <ecNumber evidence="1">6.1.1.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_42100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.11" evidence="1"/>
    <dbReference type="EMBL" id="CAHIKZ030002040">
        <property type="protein sequence ID" value="CAE1280041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CXP7"/>
    <dbReference type="OrthoDB" id="10264585at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11778">
        <property type="entry name" value="SERYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1280041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="329" mass="36898" checksum="65B82935B0521575" modified="2021-09-29" version="1">MASTSSSASGSLHPKNEKAQTTFSRLEKFDWDYLCNLKNTDEIRQNIQCRKGIGDIDTLLRVWKQFGQEDDPDEKQRLMLQLEQLASDIPNKKHPQAPVGDESCAQLVKMIGQPQADDKIKQPIVQLAEKAGWLRISNLGISTGQRSYFLQNQFAHLEQALVRFTLDRLQDQGFQLVSVPEILKPEIIEGCGFTTTGVIFKFSAWGYFFTPVGVLGWRYFFTPKPHKLTKTVSDCCGGWRAAVLVLQASLLGYSPVLTELQLNCSATALSIPPWGSVFMLVHPLLGWGRWSLGCLCKPHLRPLLANEIMASFLCVFFPCDTANEIALFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CYQ6</accession>
    <name>A0A812CYQ6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_42870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002113">
        <property type="protein sequence ID" value="CAE1281413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CYQ6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1281413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="156" mass="17177" checksum="7F1471964AADDDC3" modified="2021-09-29" version="1">MLAVDCPRLARIEQACTHAFFSLSLFLFLNSSLSISLSLHVFHPLSLSLFHSLSIPLHLSPLLLSLFLSLPQSYHFSLSLPFTLPLSLHLSSYLSFISLSLSVYPSLTLTLSYSLSLSLTLSHSFSPSPSHPTLTLYPLLSPTLSILPLLSHFLTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D1T6</accession>
    <name>A0A812D1T6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_47820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002631">
        <property type="protein sequence ID" value="CAE1289759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D1T6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1289759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="285" mass="33970" checksum="85B909E79DB2D988" modified="2021-09-29" version="1">MLLSNIPHLFLFAFVSYISALVHPVPDSFTDSLFLLVSYFFLFVRCFLFPSDLFFSFFYSLSFFSLVVFSLLSSLQYLFIFSFFSSLFFFIFVSFASIIFSFIYFLLIFLFCCFFDVRHFFSISFFVFFHSFFFFGFFFIIHLFIFSFLSVILFFLSFRQLLSFVGFLSFFPYFFFILSLSLLFFLFFFLFPTQHLSIYLSIYLSIYLSIYLSVMMLIWGSGGTTAGSRETIALITDQKSTSKSSKIYDIEWHFPFKRKMFRTNACIIIYLSIYLCLRRSFVINA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D1V1</accession>
    <name>A0A812D1V1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_45954</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002401">
        <property type="protein sequence ID" value="CAE1286354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D1V1"/>
    <dbReference type="OrthoDB" id="6163062at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1286354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="363" mass="42998" checksum="E4147C168BB7BC91" modified="2021-09-29" version="1">MIHSIAKCYHIAYDPFHPKCYHIAYDPFHPKCYHIAYDPFHPKCYHIAYDPFHTKCYHIAYDPFHRNDIELHMIHIHRSYDPFDTKCVYIINAIAYDPFDTKCDHIAYDPFDTKCYHIAYDPFDPKCDHIAYDPFHPKCYQMRSYMIHSIRNAIILHMIHSIRNAIILHMIHSNAIILHKSIRNDPIILHMIHSIRNAIILHMIHSIRNAIILHMIHSIRNAIILHMIHSIRNAIILHMIHSIRNAIILHMIHSIRNAIILHMIHSIRNAIILHMIHSIRNAIILHMIHSIRNVIILHMIHSIRNAIILHMIHSIRNAIILHMIHSIQNAIILHMIHSIRNAIILHMIHSIRNAIILHMIHSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D4F8</accession>
    <name>A0A812D4F8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_45105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002323">
        <property type="protein sequence ID" value="CAE1285002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D4F8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1285002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="298" mass="35285" checksum="92FBC242DA3CDEB3" modified="2021-09-29" version="1">MYKLFTQSYLKKVNKSIYLSIYIYLSIYLSIYLSLLIIYLSHLFLIYLSIYLSIYLSIYLSLFISISNIHIYLSIYLSICCGFRDEIQSQMIDSYLPKYSYIYLSIYLSIYLSIYLSISFYSCLSAYSYLSIYLSIYLSIYLSIYLDLFICLYPSCLHECISVCFYLSIYLSIYLSIYLSIYLSQSLHSMNLSIYLSIYLSIYLSIYLSISGPFNILALYYLHRLLILHLGCYRITSRLISVFLYFFLLPHIFFCLLPSFFSPTIFSLFFVFFLPFFFSLTTSFLSIPLFCSVFSYVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D5I7</accession>
    <name>A0A812D5I7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ACTR2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SPHA_47707</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Farmed</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the actin family. ARP2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002611">
        <property type="protein sequence ID" value="CAE1289541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D5I7"/>
    <dbReference type="OrthoDB" id="10251209at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10220">
        <property type="entry name" value="ASKHA_NBD_Arp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000538">
        <property type="entry name" value="Actin-related protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000005">
        <property type="entry name" value="Actin-related protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAE1289541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="335" mass="37757" checksum="88C7B0C598774740" modified="2021-09-29" version="1">MDNQGRKVVVCDNGTGFVKCGYAGSNFPSHIFPSLVGRPIIRATTKVGNIEVKDLMVGEEASALRSMLEVKYPMENGIVRNWEDMLHVYDYTFGRDKMNIDPHNSKILLTEPPMNPMKNREKMVEVMFEKYQFHGVYIAIQAVLTLYAQGLQTGVVVDSGDGVTHICPVFEGFSLPHLTRRLDIAGRDITKYLIKLLLLRGYAFNHSADFETVRIMKEKLCYVAYDVEQEQRLALETTVLVESYTLPDGRIIKVGGERFEAPEALFQPHLINIEGVGVAELLFNTIQAADIDTRSEFYKHISLGKGTKTALSGESTEGRYIETFEIQDSHRRPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D8I4</accession>
    <name>A0A812D8I4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_47889</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002638">
        <property type="protein sequence ID" value="CAE1289880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D8I4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1289880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="299" mass="34936" checksum="155B38FD6F83DD6F" modified="2021-09-29" version="1">MCILRISITIYLSLSFFHLIYLKSILSVKKKVLSIYLSISIYISVSYISIYLSIYLSLFISIYLSIYLSIYLSIYLTISIYLSIYLSIYLSIYLNFNHIYLSIYLSIYLSVCSYLSIFYLSIYLSFILYLSMFISVSISLSLFFILLTNRKLNAFCSSSIYLSIYLSIYLSIYHVIFIFIYLSTCLSVYLSTYLFSNMFLLGLFKLSAMVPFARSVYMHAKTRIRNLKSFNLIYLSIYLSIYLSICSLSVYSSIYVVVHYLTAHYLSIHLSISIYLSIYLSIYLSIYLSKPVYIYLSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DAS9</accession>
    <name>A0A812DAS9_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BEN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SPHA_52488</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003271">
        <property type="protein sequence ID" value="CAE1298280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DAS9"/>
    <dbReference type="OrthoDB" id="9934919at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018379">
        <property type="entry name" value="BEN_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10523">
        <property type="entry name" value="BEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01025">
        <property type="entry name" value="BEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51457">
        <property type="entry name" value="BEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BEN" evidence="3">
        <location>
            <begin position="174"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="121"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="37"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="127"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAE1298280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="290" mass="32746" checksum="689B3C3C0BBDA991" modified="2021-09-29" version="1">MELLSNYNHRYRITFTATVSYAVIRKILMSATQLMFIKAEEDDKEVLKKRIKELENENETLKQALEQLQQLQGKCCDWCELLMPSSDQERTTISNWLEGVLTALKSQKGESELIIDDNIQNSAQATPPTPPPPTPPPPTQQPPSAAAAPPPQGSVTLPNFTVSPTVSSAQPIIIRGSTMMKSLHIDYLKLKHIIRSADDRRGDKMKYLLNKLVDAMFTRDELVAASGLGIRTHKDKHHTPLDRKKLAAIKDFLEEFADKNGIQTMDPRTFRVTVGNKITNARRNLRNEFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DC20</accession>
    <name>A0A812DC20_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Structural maintenance of chromosomes protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SPHA_52514</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family. SMC5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003272">
        <property type="protein sequence ID" value="CAE1298292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DC20"/>
    <dbReference type="OrthoDB" id="6145644at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000793">
        <property type="entry name" value="Structural maintenance of chromosomes protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038729">
        <property type="entry name" value="Rad50/SbcC_AAA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45916">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45916:SF1">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13476">
        <property type="entry name" value="AAA_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad50/SbcC-type AAA" evidence="12">
        <location>
            <begin position="34"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="194"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="346"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAE1298292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="541" mass="62807" checksum="1A34631CCA369997" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DCP6</accession>
    <name>A0A812DCP6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_51681</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003142">
        <property type="protein sequence ID" value="CAE1296795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DCP6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="327"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1296795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="391" mass="45857" checksum="AAD213278AAD8D5F" modified="2021-09-29" version="1">MFISIYLSIYLSIYLSILICSYLSIYLSIYLSIYLSQYVHIYFNMFISIYLSIYLSIYLSIYLSQYVHIYFNMFISIYLSIYLLQIVPYVTFAQARVTIQSKADYRLSFCLTTSSLSSIRFRSGRGYLTSAMTFFSFLSSFLPLFLCFFVSFYNFFFFSCSPVIPFPVLFLSPRILFSFFLSFFLSFFLSFFLHVFLFSPQYLINITLSSLFGILLFISVLLFNLSFLPSFLPSFLPSFPFVRSFVRSFLPSSPSLPSSLPPFLPPSFLPSFLPSFLPSFLPSFSFLLIFLFAFFVLIFISPYFSFTFPLFARIIQYLSIYLSIYRSIYLSIYLSLFLSIYLSIYLSIYLSICMNLFRSIYLSIYLSIYLSIYLNLFRGDSVFSFCASIRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DDH1</accession>
    <name>A0A812DDH1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_50825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003021">
        <property type="protein sequence ID" value="CAE1295248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DDH1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1295248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="167" mass="19891" checksum="85C883CD77190034" modified="2021-09-29" version="1">MAGGSDPRSKDLPKQNKKERNYLSILILNLFFLSFFLNIFPSFLIFNIIHSFLIFPFLSFFLSFFLSFFLSFLIFSLPFLFLILSILRNIFPFFLSFFLSFFLSFFLSFFLSFFHNIILSFFLSFTFFLSFSFFLSFFLSFFLSLLGLLALNWQPVLQREIQDSKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DEM7</accession>
    <name>A0A812DEM7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_52315</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003239">
        <property type="protein sequence ID" value="CAE1297908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DEM7"/>
    <dbReference type="OrthoDB" id="9908684at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053134">
        <property type="entry name" value="RNA-dir_DNA_polymerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559:SF444">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559">
        <property type="entry name" value="TRANSPOSON TY3-I GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032739887" evidence="2">
        <location>
            <begin position="31"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="411"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="453"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="486"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="530"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1297908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="557" mass="64584" checksum="D3F7367A51CE3464" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DI67</accession>
    <name>A0A812DI67_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_56856</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003794">
        <property type="protein sequence ID" value="CAE1304209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DI67"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1304209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="265" mass="29505" checksum="064209F70DB7FFD3" modified="2021-09-29" version="1">MKYLSHSIAVAHSFTALTLTHSTPLTHSLLLTLFITLIHSLTTFSFSSNKKVVRVRMISHSLTALTLSLTHPLSLILSHSFYYSDFLSLSLSLSLPHVFLLFLPALFHSLSLTHSMTLFHSFIISLSLSLSLTHSVLLPLTITRAISHILAISFIHSLFHLITLFHFLSLIHSLSLSHLFTLFLTTLSLALTRALSLILTHYISRLLADSLPPSHYFTPSQSLSLSLSLILTYSHRQPHPSLTLSLSLSLSLSFFKLLISISISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DJI8</accession>
    <name>A0A812DJI8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_54116</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003485">
        <property type="protein sequence ID" value="CAE1300880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DJI8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1300880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="159" mass="17979" checksum="93F9C1ABDA6DAD3B" modified="2021-09-29" version="1">MLPDAQKIYTHILSLCSSLQFYSSFALSHSLTCCDSFQGSSLLCLPHPQYTHFLFLYLSLSLLPFAYEYLTHFSIQFILINFLLSLFLSFSLSLSLSLSLSLSQYRLLFNSLRLLGYIIALLILLPKSQSLFLIIFLFVLSFSVSLSLSLSLSLSLSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DK22</accession>
    <name>A0A812DK22_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_53764</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003432">
        <property type="protein sequence ID" value="CAE1300260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DK22"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="266"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="323"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="348"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="386"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1300260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="419" mass="48757" checksum="5CC6638ED13CBA8F" modified="2021-09-29" version="1">MFLFVCPCQIQRKRIFIRKIVYHQFITLSLSLSLSLSLSLSLSLYRSFSLSLSFALSHSFSLARSFPLPCSFSLALFLSLSLSRNLSLFMTLSHSFSLFSFLLSISFSSFLFLLFLAISLFSLFLSLSLSFPHSFLSFSLSRSFSPFSLLLSPLFLFLSFFLSFSLSLSLSLSLSLLLSIYLFHYVHIYLSIYLSISICSYLSIYLSISICSYLSISICSYLSVYLAIYLFQYVRIYLSIYFNIFISIYLSIYLSIYLSISICSYLSIYFNMFISIYLSIYFNMFKSIYLSIYLSFYLFQYVHIIYLSIYLSIYLSISLCSYLSIYLSIYLSIYLSITFSGHVYEVVLFFYIISLILFVFSFSFCSYLLFFFFSASFSMIEFYLSFLLPFFVTLHISFSSIFLFLIFLLFLPSISSSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DL93</accession>
    <name>A0A812DL93_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Intraflagellar transport protein 81 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Carnitine deficiency-associated protein expressed in ventricle 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">SPHA_56440</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">Farmed</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the intraflagellar transport (IFT) complex B: together with IFT74, forms a tubulin-binding module that specifically mediates transport of tubulin within the cilium. Binds tubulin via its CH (calponin-homology)-like region. Required for ciliogenesis. Required for proper regulation of SHH signaling. Plays an important role during spermatogenesis by modulating the assembly and elongation of the sperm flagella.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the IFT81 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003723">
        <property type="protein sequence ID" value="CAE1303652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DL93"/>
    <dbReference type="OrthoDB" id="276029at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030992">
        <property type="term" value="C:intraciliary transport particle B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042073">
        <property type="term" value="P:intraciliary transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.70:FF:000001">
        <property type="entry name" value="Intraflagellar transport protein 81 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.70">
        <property type="entry name" value="Intraflagellar transport protein 81, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029600">
        <property type="entry name" value="IFT81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041146">
        <property type="entry name" value="IFT81_CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043016">
        <property type="entry name" value="IFT81_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15614">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 81 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15614:SF2">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 81 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18383">
        <property type="entry name" value="IFT81_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="11" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0969">Cilium</keyword>
    <keyword evidence="5" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="8 16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0221">Differentiation</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0744">Spermatogenesis</keyword>
    <feature type="domain" description="IFT81 calponin homology" evidence="18">
        <location>
            <begin position="3"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="663"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="168"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="529"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00043983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00055755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00073058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00079903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF18383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CAE1303652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="682" mass="80497" checksum="C7CB0145E9DFB75C" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DLT2</accession>
    <name>A0A812DLT2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PDSS2</fullName>
            <ecNumber evidence="2">2.5.1.91</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_57364</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.91" evidence="2"/>
    <dbReference type="EMBL" id="CAHIKZ030003869">
        <property type="protein sequence ID" value="CAE1304842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DLT2"/>
    <dbReference type="OrthoDB" id="9983019at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097269">
        <property type="term" value="F:all-trans-decaprenyl-diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001:SF55">
        <property type="entry name" value="ALL TRANS-POLYPRENYL-DIPHOSPHATE SYNTHASE PDSS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1304842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="313" mass="34490" checksum="33067FB3A607305D" modified="2021-09-29" version="1">MSNAEKVVGYPTSFMSLRCLLSDELSNVALQMRKLVGTNHPLLKTARGLLYDSKHNLQTRGLIVLLIAKAAGPAKNSSTTDTMIAGISPSQRTLAEITEMIHTAKLIHKGVINLSRMKDIDKTERDELHFGNKIAILIGDFLLANACTALAELRNTKVVDMISISIKEMMESEFTDFLDVDGHPQLKETVTFSDWCQYTYLSFGSLLAHSCQAAAILAGHNRHIQECAFEFGKNLAYAHQLNDDMKPFVDSTKGSAISITAATAPLVNLIEKQGSNVFPSLMTAFTSPAQKMKVSFFPSLFFSNFFEVFVSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DTL5</accession>
    <name>A0A812DTL5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_60109</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004157">
        <property type="protein sequence ID" value="CAE1308194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DTL5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1308194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="271" mass="32454" checksum="53F9B90A83768459" modified="2021-09-29" version="1">MKDFCLNTHTHTHRVSIYLSIYLSIYLSIYIVDFNVHCISIYLSIYLSICLSFVSFFPSLDVLLFYCFFLSIFPVILILIVSFHLLLADFCLFLSPFILLCIISVIFILLLLDFIDLSFFLSFFLSFFLSFFLSFHFNIIYFLPFFIDFIFHSLASLMLDSSFFFLSFKLRIRFLSILSFFTFFFCSFSFFLLFIRSYFLLLDSIFISLIIVLFLFFIDNIFFCLSFLCFSFIHLSFFHSLNNMFPSFSHRFNIFLPIFLFIMIYSCYSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DV28</accession>
    <name>A0A812DV28_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_59648</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004126">
        <property type="protein sequence ID" value="CAE1307604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DV28"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="310"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="405"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1307604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="455" mass="51258" checksum="8DF2B671AA7D5934" modified="2021-09-29" version="1">MKEKNNIILSFFLLLFISIYLSIYLSQSVHIYLSIYLSIYLSIISFHIYLSIYLSIYLSIYLLLFSLQHSLSSLVSHSQHTFSSPLSLSPFPSHPTLSLSLLVSHSQYTLSLSLRSCLSLSSHSHSHSLLLFHSQYTLSKPLSHSLFHSHPTLASRLFFTLFWPLSLSLFSPFRFSPSLLFSTHSLFSLSFILNALSFLPLFYSQRTLFSPSLLFSMHSLFSLVSLSHFHTQHTLFSPSLLFSTHSLFSLSFILNALSFLPLFYSQHTLSSPSLLFSTHSLFSLSFILNALSLLPLFYSQHTLSSPSLLFSTHFLFSLVSLSLSLSTHSLFFLVSHSLLLLIHSLFFLVSFSLSISTLFPSSLSNTFSFSTPSFLLLSFSLFHYPDSLFSLVSHSLSLSTLSSPLSFFQSSVSLSLSFSLSLFLPLSTHCLFSVTIATSQPQFYSSNFFPHSLCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DX81</accession>
    <name>A0A812DX81_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">L-Fucosyltransferase</fullName>
            <ecNumber evidence="3">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SPHA_61984</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Farmed</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Golgi apparatus</location>
            <location evidence="3">Golgi stack membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="3"/>
    <dbReference type="EMBL" id="CAHIKZ030004396">
        <property type="protein sequence ID" value="CAE1310385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DX81"/>
    <dbReference type="OrthoDB" id="3226at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008107">
        <property type="term" value="F:galactoside 2-alpha-L-fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11301">
        <property type="entry name" value="Fut1_Fut2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002516">
        <property type="entry name" value="Glyco_trans_11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11927">
        <property type="entry name" value="GALACTOSIDE 2-L-FUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11927:SF9">
        <property type="entry name" value="L-FUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01531">
        <property type="entry name" value="Glyco_transf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="2 3 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="226"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU363129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAE1310385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="261" mass="30372" checksum="76450F6B6E3B789B" modified="2021-09-29" version="1">MVTFIPDDLELWTLFEVDSYVGGVESLKNFNRPKPVSSCNLNSYEEISAAVYSRNITNLPHQDTIIYGYLQSFKYFDFMKSEILQHQFHFKEKYRNLAEVMLQRAITTHKSNVQSRNGYLVDIVVVGIHVRRGDFVRSQSQGYVPAPLPYFYRAMNYFHTRYPNVMFFVCSNEIIWCKKYLDDDNIFYSDSASDYVDLAALSLCNHTIISSGSYSWWAGYLNRKCIIVHLSICLSASVSFLSIYLSIYLSIYLSIYLSIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DXL6</accession>
    <name>A0A812DXL6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_62645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004486">
        <property type="protein sequence ID" value="CAE1311173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DXL6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1311173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="274" mass="32400" checksum="2FC4D4051AA3FDBC" modified="2021-09-29" version="1">MNSSVLRGGHPALTLSLSKLLNVALSSTSKASCLAPLACGTPFPIPYLSKGRKFFIFLLSFFLLIFAFNKTFIQKFFHFFLSFFLSFFLFSAIHSFIPFFLSFHFISLRFTLNLLEISLFFHYSVSISLSLEDFSPFFCFSLTFSLLMHLFHFETSLFLEFFSKNNLAFFFFISFSFFFLDIHSFFFAYYDFFSDTRFFFLFFFLISQFLSFPFPFIFSFLFFSSSHHRCPSFLSAFLSSFVSGFLFQLSFYLCHTVKLSLRRRRDKRAHAHTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DZP0</accession>
    <name>A0A812DZP0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_65397</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004722">
        <property type="protein sequence ID" value="CAE1314427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DZP0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1314427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="219" mass="25846" checksum="869F9D7C4C990CAE" modified="2021-09-29" version="1">MIFTDEKRFKFDGPDGSRKGEPIILNKRQMGGGGVMGYGISEWKLVARVLNIYYLNSIYLSIYLSIYLSIYLSQFIAIYLSIDSIHYLSIYLSIYLSIDFIHIYLSIYLSIYLSIYCCKSIHIYLIYSLSIYLSIYLSIYLSIYPSFNVSLFIIYLSIYLSIYLSIYLSIYLSLFISIYVSIDIYRYVCSYLSLFIIYLSIYNRISIYLSIYLSIYLYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E0R0</accession>
    <name>A0A812E0R0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_63412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004545">
        <property type="protein sequence ID" value="CAE1312133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E0R0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="287"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1312133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="311" mass="36350" checksum="2F44035FE5353B74" modified="2021-09-29" version="1">MGIGLEQGHRCWAHKEELARLFSSHRLRPLLANNPYIVCNPASFFFFFFFFFFFFFFLIFFFFVFISYSSSSSSSSSSSFFFFSPPPSYYFKKNKYPPPTLFSLSSSSSSHSPTLQASSYSFFLCLPSSMQPPLSPLSTATTTITLSTLSECAIRYLSIYLSIYLSIYLSIYLSIYLAKGLTAISHTYHYYCNFLSLSYILFSIYLPQFFFLCIHLRHFDLSILYLSLFVVFCLYLISVFIYYLSLSLSLSLYLSIYLSIYDLSLFLNSVVFQFLKKCFFLNISFPFLSIYLSIYLSIYLSIYLSMLYLYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E152</accession>
    <name>A0A812E152_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_64368</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004631">
        <property type="protein sequence ID" value="CAE1313218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E152"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1313218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="225" mass="25853" checksum="74BDAD9234CAF017" modified="2021-09-29" version="1">MSPTRSIYLCLLLELSIYLSIYLSIYLSIYPFSHTLSLSLSSPPPHTHSFSRTLFPSLSHSFSLSLFSINLLLFLSHYLSLSVCLSFSLSPSLFLSSLAHCLSFTLFLSVSLSLSRFIHKSPSLSLSLFLSSPPLSRVRYITLSFFLSFFKVILFIFLSFFLSYISLSFFLLKISPSFFLSFFLSFFLSFFLKFPLFLSFFLSFFLSFFLLKISPSFFLSFFLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E2G4</accession>
    <name>A0A812E2G4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_66602</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004810">
        <property type="protein sequence ID" value="CAE1315764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E2G4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1315764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="370" mass="43899" checksum="FCB70E158CFAE85D" modified="2021-09-29" version="1">MSNYLRAMFTFQFFPSFFLSFFPSFFLSFFHSFFLSFFAFSQILSFFLSFFFLSFFFLSFFFLSQILSFFLSFFFLSFFFLSVFFLSFFLSFFLSLPVSKQYLISKPFLSLFSFLSFFLFSFFLFSFFLFSFFPNPFFLFFVLILFLSFFLSLPFPSFFLIQFSLHFSFNFSKFSFHFSLSLSPPTSKRSPVSSSLIITFLLFLLIFYFDFLFSPFSLTLFFPSLLSFLTSLSFPLPPLLPFLHSSLSLLIFVPFSHPSLFLLPLLSFLTPLSFPLHYYFLFILFSFSYPLFSTLTFPPLLSFRLFFPLLTCFSFAPIFLQRSFFHPPPFFFTALSFPSPTLSFLTSFSFSPRLSLFTPLPLLSFLKRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E2K6</accession>
    <name>A0A812E2K6_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SPHA_64867</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Farmed</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CAHIKZ030004677">
        <property type="protein sequence ID" value="CAE1313817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E2K6"/>
    <dbReference type="OrthoDB" id="341578at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004694">
        <property type="term" value="F:eukaryotic translation initiation factor 2alpha kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000251">
        <property type="entry name" value="eukaryotic translation initiation factor 2-alpha kinase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF91">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="374"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="323"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAE1313817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="705" mass="80616" checksum="5CE2EE85218AF60D" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E2R4</accession>
    <name>A0A812E2R4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_64967</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004679">
        <property type="protein sequence ID" value="CAE1313936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E2R4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1313936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="300" mass="35850" checksum="E253BECA83E51B43" modified="2021-09-29" version="1">MFCRYIEFKIFKRELSCNYSEKFNIDISIYLSIYLSIFVHSRYFSFELSRFTSFFLSFFLSFFLSFFVLSFFLSFFLSFFLSFSACLFVYFFVSLFVSLFLCLFLCFFVCFFLSPSVCFFLIIINHSLLLIYLFNYSFFFRFFLSKQVWSPLYLSIYLSIYLSIYTTAIFNRLFSCKKYALLSLSPPSLSLSIYLSIYLSIYIYMLAPEPIHTKKILLKNPSIYLSIYLSIYLSIYLSIYLSIIIYLSIYLSIYLSIYLSESIYLSIYLSIYLSTDLPVHIYLSIYLSIYLSIYLSIYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E2Y0</accession>
    <name>A0A812E2Y0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_63746</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004577">
        <property type="protein sequence ID" value="CAE1312477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E2Y0"/>
    <dbReference type="OrthoDB" id="6425635at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1312477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="251" mass="27864" checksum="AA4530E19C7E9434" modified="2021-09-29" version="1">MPPKRRKLLGRRTAAAFAARAARASETPEQTSLRLSRMASSSAARLSMESAAARTERLASAASTMSARRASLSIKERSLQNSQEAVRVARLRASQSPAQKTLHSLRDVTAKAYSRGLESSEQTTTRRLRNTRATAAARASEQPQETAHRRFRNARSTASARTLKSPAQTTVRRVRNALSTASATALESPEQTTVRRVRNARSTASAENSEVRRQRLENISISSFFEWHNFAVCVILVKCHIQLCMHCQLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E3P9</accession>
    <name>A0A812E3P9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_65076</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004686">
        <property type="protein sequence ID" value="CAE1314041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E3P9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1314041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="175" mass="21418" checksum="6DFE874DC4D672EE" modified="2021-09-29" version="1">MADIFLLVRPFSLDSAYFFHYFQYFHFRYSFFYSIHFPILLSAFDYLFLLFICLHLINYHSFCTFLCAICQSYVRFVRHPSSLYLFSVSSSFSRLLLAPFSLFLFYREHMFRSHDCLFSFLFLWLKAFSLFIFLAFLFFLSFFLPFSFSLERVKSIYLSIYLSIYLRRDSVKSWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E4B5</accession>
    <name>A0A812E4B5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">KIF26</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_65994</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004749">
        <property type="protein sequence ID" value="CAE1315038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E4B5"/>
    <dbReference type="OrthoDB" id="8862460at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21608">
        <property type="entry name" value="KINESIN-LIKE PROTEIN CG14535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21608:SF7">
        <property type="entry name" value="KINESIN-LIKE PROTEIN CG14535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="760"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="762"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="780"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="818"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="835"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="868"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="898"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="946"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="964"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1006"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1059"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1074"/>
            <end position="1085"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1315038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1113" mass="121788" checksum="CE16C86033FEF70E" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E6C0</accession>
    <name>A0A812E6C0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_67915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004925">
        <property type="protein sequence ID" value="CAE1317336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E6C0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1317336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="236" mass="29038" checksum="9E489296C6100C79" modified="2021-09-29" version="1">MMEKCFSDIFLWLYSLFIFLFFFLNFFLSFLLLLFNFFWYSFFFPSFFRFFFHTFIHSYICFFIFYKCISFVLGFIHLFSFIRLFFLLLLPSNSFLSFFLSFFLSFLRFRTHSFFLIFVFSFFCLISFSHFSFIFICYFLSISSNFFISFVFSTTLSAFFFLYFFLTINFLYFLISSNPRCFLFSFFLSFFLFFLYSPYLTTFSFFLSFIFPSPTSSSFFILIYISLLSAYISFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E6V3</accession>
    <name>A0A812E6V3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_65484</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004724">
        <property type="protein sequence ID" value="CAE1314472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E6V3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="349"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1314472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="372" mass="44978" checksum="D572691C0896E5B3" modified="2021-09-29" version="1">MVHFFAIQIILFEVIFEDKKIYLSIYIYISVRYLSIYFLLFITDLSRCYLSIYLSIYLSKPIHIYLSIYLSIYLSIYLSYLAIKLSIYLSIYLSIYLSIYLSISVCSLSISLFIIYLIYFFRSPVFNIFFLFSFFFLSFILFFFPSFFLSPIFTFFSFFLLFLLFFFLFPLFLSFFLSTIFIIFLSFFLLSFSYFYYVFFLFSYVLLFLLSFSLLFFLSFFLSFFLSFFLSFILSLSYSFFHSFFLSPIPSFFRYFSLLFFLSFFLSPNLSFFHSFSLLIFLSFSLLFFHSFLLLFLISFSVLFFLSFFLLFFHSFFLSLISSFFRSFSLLFFLSFSLLFFLSFFPPSIFTSSLSPILSFFLSFFLSFFLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E8B0</accession>
    <name>A0A812E8B0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_66534</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004804">
        <property type="protein sequence ID" value="CAE1315701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E8B0"/>
    <dbReference type="OrthoDB" id="6783874at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1315701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="205" mass="24186" checksum="8BA20E8638C5CBC6" modified="2021-09-29" version="1">MFTAFFLIYLSIYLSIYLSIYLSVCVFVIAHISSLCLLTLSIYLSIYLSIYLSIYLSIYFSPFISIYLSIYFSPFISICRFQSVHIYLSIYLSIYLSICLSVCFSLFISNSNQQTIHINLSNYYCYFEKMNNIGPGLRLRGIKGLELFRQRKLRRILRISFEDRITKNKVLNRISLPNIEATILQHLRLIYKYNLSIYLSIYLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EB33</accession>
    <name>A0A812EB33_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_71792</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005263">
        <property type="protein sequence ID" value="CAE1321744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EB33"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1321744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="314" mass="38988" checksum="BC7DCCBD1CCCDAC1" modified="2021-09-29" version="1">MHNRTPRCYRRLQPLLKLIDASNLSLSLSLSLSLSLSLSLLINSSPENQEIFRFANFLFSFHFSFFLFFSFFFFFSFLISFHFYFYFSSFFLLFFFSFFFSFFFSFFFSFFFFFLFFFLLFSFHFSFFFSFFFSFFFFFLFIFLLFSFHFSSFFLFIFLFFFFSFFFFFSFHFSFLFSFHFSSLFLFIFLLFSFLFFFTLDSCHLLFRLFFILFSPFSAHTALYNSLYTFYLPLLYPFSLMPISPHLTLLVSHLTSSLKCYHPFFFFFFFFFFFFFIIIIIIPLFFSYLFLPHLLFYFIFFFFSSSIPFSSSYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EDJ5</accession>
    <name>A0A812EDJ5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_73260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005370">
        <property type="protein sequence ID" value="CAE1323321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EDJ5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="286"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1323321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="343" mass="41220" checksum="0859FEE60F267354" modified="2021-09-29" version="1">MFSAATRESLGILFDKHSRCNFGGISLFSSLLSFFLSFFLSFFLSFFLNDLIFLFDFLVSSSYKQFLKIFYFFFLYFFFLSLSLPFFISIFHSFLFLTCSLSFFLSFFLTCYFHFFSFFLSFFLSFFLSFFLSYSFFTSYPFPRFFLSFFLSFFLSFFLSFLHVISTFLSFFLSFFLSFFLYFLPISPLLSFFLSFFLSFMLFPLFLSFFLSFFLYLLAVSASLSFFLSFFLPVNSSFSFFFFSFSLSFSFFQVVFPSFILSFLFSFSLFLSLFVSFFLSFSFSIFFAFLIFLFLLTYVFFIFFTFPFFIIYLSFPYAISLSLSLLFFFFKSRKYSFDVFPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EEP8</accession>
    <name>A0A812EEP8_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CARMIL pleckstrin homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_71220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005210">
        <property type="protein sequence ID" value="CAE1321048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EEP8"/>
    <dbReference type="OrthoDB" id="18598at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041245">
        <property type="entry name" value="CARMIL_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17888">
        <property type="entry name" value="Carm_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="274"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="335"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="370"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="424"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="CARMIL pleckstrin homology" evidence="2">
        <location>
            <begin position="4"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1321048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="458" mass="50344" checksum="371A30022214DDCE" modified="2021-09-29" version="1">MAKLAFSNWRLIILIARPPCKIEHSFHYIDILAIESFKRNQHDVAISHYCYSLLTIITVLSLSSQLLLCSLSPHNYYCALSLLTIITVLSLSPHNYYCALSLSSQLLLCSLSPHNYYCALSLSSQLLLCSLSPHCYYCALSLSSTIITVLSLSPPVCLSLSLPGVLCSLSSQLLLCSLSPLVLLCSLSLSIITVLSLSLTIITVLSLSSQLLLCSLSPHNYYCALSLLTIITVLSLSPHNYYRSLSLLTIITAPSLSSQLLPLPLSPHNYYCSLSLSLLTIITAPSLSLYLQLLLLPLSLSTYNSCCSSLSLYLQLLLLPLSLSFQSFLLPSLSLLTIITAPLSLSLTIITAPSLSLLTPLSFLLPLSIYNYYCSLSLSLQLLLLPSLSLYNNYYCSLSLLQLLLLPLSLSTYNYYCSLSLSTYNYYCSLSLSLLTIITAPPLSLSTYNYYCSLSIYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EFA2</accession>
    <name>A0A812EFA2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WDTC1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SPHA_74162</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005408">
        <property type="protein sequence ID" value="CAE1324423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EFA2"/>
    <dbReference type="OrthoDB" id="4869960at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045717">
        <property type="term" value="P:negative regulation of fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045151">
        <property type="entry name" value="DCAF8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15574:SF40">
        <property type="entry name" value="WD AND TETRATRICOPEPTIDE REPEATS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15574">
        <property type="entry name" value="WD REPEAT DOMAIN-CONTAINING FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="43"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="86"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="402"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="584"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="614"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="347"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="526"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="363"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="385"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="526"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAE1324423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="660" mass="74490" checksum="07526B8F9059358D" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EFH7</accession>
    <name>A0A812EFH7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_73483</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005380">
        <property type="protein sequence ID" value="CAE1323618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EFH7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1323618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="326" mass="37543" checksum="5963129961A47A10" modified="2021-09-29" version="1">MTKDVLHEVFYYLRHLNNVFSIPTSNQLKVYTKYLDYSVSEFSFFFISSLSSLSLSLSLFLSIFLFLSFFLSFFLSFFLSLSLSISLFLFLSLSLSLSFFLFLSISLSLSLSLSLSFSLSLSFFLFLSFFFSFSFSIFLSFSLSFTFSLSFFLSYFLCLSLYFSFSLFLFLSLFLSFLSFFLSRSFSFSLSYGTDLDNSVYEFSFFFISSLSSLSCSLSLSLSLFLFLSFSLSISLFLSFALFFSLSLFLSLSLSLPLALFLFSLFLSRFLFLSLFLSLSISLALFLSHTQKTHTIFFPVCSLNLSAFPRTQMYGDNYYINNNNNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EGK6</accession>
    <name>A0A812EGK6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_70881</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005192">
        <property type="protein sequence ID" value="CAE1320654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EGK6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1320654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="183" mass="19749" checksum="E8134CEDD2E21656" modified="2021-09-29" version="1">MSVSHFSSSYPFYTHFPSSLPPSFFLPPFPLLFSFLPSHFFFPSSLPTSFFLPPFPLLSILSPPSPLFLPLSFSPSLSPPLFLPPLFLPSLSPLFLPSLPLSFSSLLSFSPLFLSSPPPSLSPLLSPLLSPPLSPLSPPLLSLSLSSLSLLSSLLLSSLLLSSPLSSLFFLISLLSSCTSFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EII8</accession>
    <name>A0A812EII8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_72959</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005352">
        <property type="protein sequence ID" value="CAE1323063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EII8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1323063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="178" mass="20894" checksum="8EACA86027C50708" modified="2021-09-29" version="1">MKIPFTTLVRYLSKRLLTSALRQSTKCPIFLLCRFLPSFFFLSFSFSSSSFLPNCIMRDGLANHCTTSRLLLPSCIHLISFVHSFVHSFLLSFFPSLFRCFFLTTTAIFTFLLLFLIYSFLYSFFPLLFVRSFLPSFFLSLLLFIDSFLYYFFFDECCLFILNEISCPIFTEVTTEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EIR1</accession>
    <name>A0A812EIR1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_71943</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005273">
        <property type="protein sequence ID" value="CAE1321931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EIR1"/>
    <dbReference type="OrthoDB" id="6161790at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1321931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="225" mass="26100" checksum="E76B209C9840FF38" modified="2021-09-29" version="1">MGALMAYWTISKFERRDSVNSVRKFTLTLSSLPTTSVSFFSLPPTWSVCLSVYLCSYLSIYSPLFISMYLSHLLHIYLSFYLSQSVHIYLSMFCDIFVYLFISIFVCLYLSIYLSIYLSIYLSISVCFYLSIYLSIYLSIYLSLSSSSLQITIARAYIMRHCFFYSLHRLQTPSKAICQKDNDANASGTCDIYQLLNLSIYLSIYLSIYLSIYLSQSFSYLSIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EQ86</accession>
    <name>A0A812EQ86_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SSD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_78958</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005555">
        <property type="protein sequence ID" value="CAE1329459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="312"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="354"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="390"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="418"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="477"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="508"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="538"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="572"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="596"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="644"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
    </feature>
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    </feature>
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        </location>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="1330"/>
            <end position="1353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1359"/>
            <end position="1379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1391"/>
            <end position="1414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1420"/>
            <end position="1441"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="2">
        <location>
            <begin position="974"/>
            <end position="1146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1329459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1465" mass="165136" checksum="42FFF03A578FDDDE" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ER17</accession>
    <name>A0A812ER17_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_78512</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005542">
        <property type="protein sequence ID" value="CAE1328887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ER17"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
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        <location>
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            <begin position="151"/>
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    </feature>
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            <end position="256"/>
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    </feature>
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        <location>
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        <location>
            <begin position="354"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="386"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1328887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="427" mass="51179" checksum="75378D0868EC11E2" modified="2021-09-29" version="1">MSWNEPKDLLVNHYLLERLLFLRCIFIHLYRCDYRIFLRFFLFHKSFLLLLLLLLLLLLSPHPFLLSLLLFFIFLFIFHSFFFSLLPVLIPFPLTLFFFFFFFFFFHLILFFFPSSSFSFSYSFSIHSFSLLLPFSFLFPLRSSSSSSSSFSFFFFLHSSLILFIFSSYSHSFSIEPDIKSHVICLSVYLSIYLSIYLSLFIYLSIYLSIYLSQSLHLSIYLSIYLSKSLQLSIVIVIVAVVFVVAVAINVVVVLLVFLRRILLLLLFLPFVVVVFLLLFFVFFFSSFSSSFSSSFFFSSSFLPFLLLFFFFLFFFFFFFLLFFSSFFLFSSLLFSSSFLLFFFLLLSSSFSSFLLFFFFLLLFFFFSFLFSSFLLLFFFSSFLFFFFFFFFSSSFLLLFFFHFFFSSSFLLLFLLLHRLLFNKTNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ERL4</accession>
    <name>A0A812ERL4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_80793</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005610">
        <property type="protein sequence ID" value="CAE1331611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ERL4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="13"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
    </feature>
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        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="331"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1331611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="361" mass="42266" checksum="0F41A1BCE34F8184" modified="2021-09-29" version="1">MAEVFFFLDINEFAIIFFHACFSSSSSYFCLLFLSLVFSFSCPFIFPLRLFLFLFSISYFSRFLVVSIVLPFFFLVILPSLSLFSLSISTSFSLLLLSLFFYFLASFSLFLVNFHLFLSFSCYFPASFSPFLFIFPPVFKKIISIFPHLSFFLLFPCPFSLFLVIVPPLSFFFFLFSCLFFSFTFIFSLLSLFFLLFSISFSFFFLFPLLSLFLFSRAFLHFSYFLTSFSLFLFIFPPLSLVIFLPLSLFFLLFPCIIPPIYLSLNSLFVSVCSLSIYLSIYLSIYLSIYLFQSLHYLSIYLSIYLSIYLSIYLSIPVSTLSIYLSIYLSIYLSISIYLSIYLSIYLSIYLSIYQYCGGFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ET39</accession>
    <name>A0A812ET39_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_76980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005500">
        <property type="protein sequence ID" value="CAE1327510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ET39"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="290"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="344"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="381"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1327510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="411" mass="48192" checksum="95B39042E3B2F006" modified="2021-09-29" version="1">MQLLYNKLGRHPTPPPFQQTSFFLCTYSRDLKKKAGSVSFQCYFSILSFPSSFLSCLIPFYYSPSALSLSLSHPPFSLSFSLSHPLSLLLSRSISLLLSRSISLLLSLSLSLSLSFLLLPFFSFFYSNPRFFFLSSSLIMLFHLFFLSLSLSLSLSCSLARFQFLRPLTISSYMEAFYNIYFPIFSYLSIYRSIDLYICLFQSFPFYLSIYLSITVISYLSIYLSIYLSIYLSRSFHIYLSIYLFQFFISIYLFQYFHIYLSIYLSIYLSIYLSIPVFSYLSIYLSNQSIYFSFSIYLSITIISYLSIYLSSYLSRSFHIYLSIYLWVAFPPSYSFFSFSLRSIFLFLPSFLPPYFLPSFLPRPLFSSPFLSLTFLYYQLSFYYFLGPSFFNSIPPFLTLSLSIAFARLQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EV42</accession>
    <name>A0A812EV42_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_80017</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005588">
        <property type="protein sequence ID" value="CAE1330760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EV42"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="319"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1330760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="384" mass="44472" checksum="7D0309B6354CD593" modified="2021-09-29" version="1">MKYLSIYLSIYLIVSLSLSLALCHSLSLSFSLSLSLSLSLSPSREVSLPWQTNWKKERSFSLYLFSSFFFSLHSLYFLSLSLSLFSFLFFSNLSLFSFVFSLFIFFRLLSLYFLSSPLSLFSFVFSLLIFFRLLSLYFLSSPLSLFSFVSSLFIFFRLLSLNFLSSSLSLFSFVSSLFIFFRLLSLYFLSSPLSLFSFVFSLLIFCYFLASFSPFYILSDILFRFSLSLALSLSLSLSLSCHFVLPLLFFYQFVHLLPNSFATAFIIFDLISSIFRFIPNPYSTCSFSYEYLKGYSLLIKSLFLYGCVPKLFLNINLSIYLSINLSIYLSIPNLQFFSFLLSLHSFSLLSYSSIVSLSVSLNFFRFLPFFNFHSFSFHFSSFVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EXF6</accession>
    <name>A0A812EXF6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_81198</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005626">
        <property type="protein sequence ID" value="CAE1332103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EXF6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1332103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="270" mass="31892" checksum="F9B385B263FD2BCB" modified="2021-09-29" version="1">MDIQVFQISWQLKTVEVKFQTFFDKRLAPRNKEIETLYKDGLKSPKIVHKTTNGLYVFVDSRLAIRMNATQSSQITGKQFEPLLSLSHPIFVSLLSFSPTPIFVSLLFFPTPYLFHCFFFPTPIFVSLLFFVSLLSHPPYLFHCFFPPPPYLFHCPHPIFVSLLFFSPPHICFIAFFFPTPYLFHCFLFPPPHLFVSFFFFFFSPPPHICFIAFFFPTPYLFLLFFSPFCFIFLFPHPHICFIAFFSPPPHICFIAFFFPHPHICFIAFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812F0L4</accession>
    <name>A0A812F0L4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_81191</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005626">
        <property type="protein sequence ID" value="CAE1332121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812F0L4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1332121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="283" mass="33651" checksum="0D0191C1A03F0E9B" modified="2021-09-29" version="1">MEEDEKIKTPIKIDLYLSMFMALSIYLSIYLSIYLSIYLSHYVHLSIYLSIYLSIYLSIYLSHYVHLSIYLSIYLSHSVHLSIYYILFIYLYIYLSIYLILFIYLSIYLSIYLSIYLSISFCSSLFLSLSIYLSHSVHLSITFRSSIYLSKTERERERERERERDPLPNASDPITDSYFYAALSIYLSIYLSIYLSIYLCIRMFISRIKCNASIEHSQRMEKGGKRRCMKPETQEERSLSHHIKLCLIVCLSIYLSIYLILFIYLSHAVHIYLSIYLSIYLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AJK1</accession>
    <name>A0A812AJK1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_1524</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000043">
        <property type="protein sequence ID" value="CAE1145002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AJK1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="217"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="389"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="445"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="471"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="497"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="521"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="557"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="617"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="648"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="679"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="710"/>
            <end position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1145002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="743" mass="84928" checksum="AEA5E18C3C289DB1" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AKI9</accession>
    <name>A0A812AKI9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_204</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000002">
        <property type="protein sequence ID" value="CAE1138184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AKI9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1138184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="248" mass="28015" checksum="81B285F71B40B276" modified="2021-09-29" version="1">MSRVTDDVPKRNEMKNKEYRKSAVRAIDSVAIRRESVSHHSVMITRPFLTLIYLCLFYLSISVCSYLSLLLSIYLSIYLCLSIYLCLSLSLCVCVSVYISMSLSLSLSIYLSIYLCLSIYACLSISIYIYLSIYVCLSLSLSVSLSVYISMCLSIYLSLSLSLSMPVNLSLSVYLSLYLSIDLCLYLHVSLSVYISMCLSVCLSISLSLCIYLSIYLSIYLSIYLSIYLSIYLSVPLYISLYISYNSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AN77</accession>
    <name>A0A812AN77_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_1154</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000031">
        <property type="protein sequence ID" value="CAE1142924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AN77"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1142924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="206" mass="24179" checksum="576CD8567E09F64A" modified="2021-09-29" version="1">MFLFLELLLTVIHRLSWLVHPYVYNLSIYLSIYLSIYLSIYLSQSDISFSLYFCLSISVDVYVSLLISISIYLSIYLSIYLSIYLSQSDISFSLYFCLSISVDIYVSLLISIYLSIYLSIYLSIYLSISTYLSQSVVIYFNRFISIYLSIYLSIYLSDNDDDDRCDSIFFTCLLIPIRPFIRFETNLQPPLLIPTSSFIFLFKIRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ARG0</accession>
    <name>A0A812ARG0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_3626</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000110">
        <property type="protein sequence ID" value="CAE1152960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ARG0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1152960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="435" mass="47855" checksum="BA44CFA83537A939" modified="2021-09-29" version="1">MPAFSFSLTTDFFQDVSADLVFALSVNEAIFSVLLGIRYWGVILISRCFYFLYLDIFFSLFTEVDASSGNPIFDDVPSDSETNESDTDDFVFDDCPLSTFSLQSNIDKKYFTVLDIAHNTGEKLDKIRELCQPNIFTMKFDKFVNETKSLACLQATMSRIIAQKSDFVELIDADEYNNAMAVLSGRPCNDSKKILPLNHPSTSTNSKIGTNSSKCKDQISDKAFNGQERALDKDIPLSPFSMSDDEASHLDVANSGYFEVSPDLSTYSAKENTTVSTRTANVTTTLATKIESVSTAEKSHSTKISDDSDNYQESVAETSVPTLSFKDKFVGGQTRTTKKKRVAMDSVFPGSKSATATVAGAATSVRHNGHFTIKMGNLPDDYYQAFGIDQTGGVSDHSGKSPRKISKDPPHSYTENLDCSKKDQIPTDSSVVIDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ASL7</accession>
    <name>A0A812ASL7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_4847</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000158">
        <property type="protein sequence ID" value="CAE1156619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ASL7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="296"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1156619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="330" mass="38163" checksum="4342DEE9A5521CAF" modified="2021-09-29" version="1">MFSSLFLFSFLSLPFLPRVARVRIFITAELCCVYIYIILLITIFLSICVHIYLSVFISIYLNLHISIYLSVSVCSYLSIYLSIDRSISCVISIYLSIYLSIYLSVFSIYLSIYLSQCVFYLSIYLSISVCFLSIYLSISVCFLSIYLSQCVFYLSVYLSQCVFYLSVYLSQCVFYLSIYLSVFSIYLSVFSIYLSVFSIYLSISVCFLSIYLSISVCFLSIYLSISVCFLSIYLSIYLSVFSIYLSIYLSVFSIYLSMLSIYLSQYVIYLSIYLSVLSISLSQFVIYLSIYRSLCYYLSISMWYLSIYLFSLSLSCKKAEVMRNGLPGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ATL7</accession>
    <name>A0A812ATL7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_4868</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000158">
        <property type="protein sequence ID" value="CAE1156558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ATL7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1156558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="223" mass="26999" checksum="5141DB120F357E20" modified="2021-09-29" version="1">MILFFLVLPSLNSITFSFSKNYLFFYPFSIFYNYFFLFPLHILLLFLSFSSLSIFYYYFFLSPPSPYFISISFFLLPLHILFLFLSFSSLSISITISFPLFQTAFFSLLHILSSFPSLRTAFVSIPSIFYYYFFLFSSFISITISFILFLLYKLSLILFPLLYLFLFYFYLFILHILSFHPEWMCICACNFSFFFFSIFFLTLSMIFFFFLTFYSFSMFFFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AV80</accession>
    <name>A0A812AV80_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SLC26A10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SPHA_5302</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000177">
        <property type="protein sequence ID" value="CAE1157582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AV80"/>
    <dbReference type="OrthoDB" id="288203at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00815">
        <property type="entry name" value="sulP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SpoIIaa-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="302"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="383"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="419"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="458"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="483"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="515"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="6">
        <location>
            <begin position="569"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAE1157582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="743" mass="82892" checksum="91ACA335901C773A" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AZM3</accession>
    <name>A0A812AZM3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_8643</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000281">
        <property type="protein sequence ID" value="CAE1165892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AZM3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="360"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="406"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="437"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="470"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="499"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="524"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="553"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="591"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="628"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="654"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="679"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="703"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="743"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="808"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="833"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="869"/>
            <end position="900"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1165892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="917" mass="108470" checksum="21FA6B378DCAC8E4" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B0Y7</accession>
    <name>A0A812B0Y7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_7385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000237">
        <property type="protein sequence ID" value="CAE1162633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B0Y7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="266"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="320"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1162633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="351" mass="43036" checksum="DC1D4B0189F651DE" modified="2021-09-29" version="1">MISLRYQQNFTAYVLFLICISIYLSIYLSIYLYIHYSFFFLYPGVTFPFLTLHLTLIYLSFFLSFFLSFFLSFFLSHFASFRSTFLMIYHFIIFPILLRIFHLEAFYIFTVHLSIIFLMHSSFHFFIDFVLFIFFYLNFSFLLLHSFMFISHSFRSFSALLFSFFFNLTGISLFSFFNLFLFSFLSFLSFLFLSFFLLKIFLSFVNYFFCFSIFISFLYFFLFNLIIFILYFNSVIFSYFFSFVLSFLLSFHFFFLFLIFSFCLSLFRFLLLFFFLSFFFYLFSSFIFYFFLISFVCFVFCLLFFCLFLSFFLSFDFILAILFPSIFFLSFFLSFFLSFFLSYPIYSAYTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B134</accession>
    <name>A0A812B134_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_8895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000287">
        <property type="protein sequence ID" value="CAE1166466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B134"/>
    <dbReference type="OrthoDB" id="5977230at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33995:SF7">
        <property type="entry name" value="BURSICON SUBUNIT ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33995">
        <property type="entry name" value="PROTEIN CBG18546"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032337685" evidence="1">
        <location>
            <begin position="26"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1166466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="269" mass="31484" checksum="83CF05BBBCB857C1" modified="2021-09-29" version="1">MIVRIFNKPLISFFFQYILIHLTLYKGQMQTQVTGDWTTSIPENLLAENNQTWRLVKCIYDSEDVASTETRVFGDDYTMAKKRQWNQMNASEFKKVDEAKLEKPSKYKYGNRRPTLVEALTNGDKLPMRIFWALFSQLSAISDFPDEETLNKIRKCSPSGTIYDSHVILCPFCRVRTKLPLGHIPPYIDEVICEQTNVACFQKQGKCFQRYMKITALRNIHGSHCLLADQNGHQFWTGNWEIYDQKVRVSCECLLDKRSRFLKYALSYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B1I1</accession>
    <name>A0A812B1I1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_7607</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000245">
        <property type="protein sequence ID" value="CAE1163228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B1I1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1163228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="164" mass="19231" checksum="DB3ACCD27E87DD65" modified="2021-09-29" version="1">MSFSLFLLHQIFFLRQYGQVSFSFSSPEMFFFMLSTNVFFLVSSPPNVFFLVFFFHQMFFLLVFFPLQNVFFPCFFLLHQTEFFLVSSPPNVFFFLLAIIINGSFPPNVFSLFWPPPHVFFLVSSPPNVFFLGTFFSTKCLFSVVSSPPNFFPCFNLHVMSFFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B2F0</accession>
    <name>A0A812B2F0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_8634</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000281">
        <property type="protein sequence ID" value="CAE1165947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B2F0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1165947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="226" mass="26402" checksum="CA5EDF9C453C827F" modified="2021-09-29" version="1">MLTKPDKYLSIYLSIYLSIYLSIYLNLFQYLSIYLSKSVQYLSIYLSIYLSIYLPLYIYIYIYIYIYIYMLEQPIINIHIPLTNLSIYLSIYLSIYLSIYLSLKICLSAQNLSIYLSIYLSTYLSIYLSIIWKYVSTCRPTDGCRVRQTSILSNILESKVKSNTKAAIKVDIINMERKVVTKSFSSFRSNLAKVVAVNGGSRWWPHRSHLSIYLSIYLSINPCLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B5G9</accession>
    <name>A0A812B5G9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_10459</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000336">
        <property type="protein sequence ID" value="CAE1169143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B5G9"/>
    <dbReference type="OrthoDB" id="377119at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1169143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="347" mass="41369" checksum="C5B63C61B011D204" modified="2021-09-29" version="1">MKHRFLSDLRLKYRCTSDVTVLVWLKIETPVHVRLKSDEIRCFNPKLDENLKLDENLKLDENRCFSPKLDENLKSDEIRCFNPKLDENLKLDENRCFNPKLDENLKLDEIRCFNPKPDENLKLDENRCFSPKLDENLKSDEIRCFSPKLDENLKLDENRCFNPKLDENLKSDEIRCFNPKLDENLKLDENRCFNPKLDENLKSDEIRCFNPKPDENLKLDENRCFNPKLDENLKSDEIRCFNPKPDENLKLDENRCFNPKLDENLKSDEIRRFNAKLDEKLKLDENRCFNPKLDENLKSDEIRCFNPKLDENLKSRSLIWTRTGVSSGSRKPEENEKSFMFLVRLQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B626</accession>
    <name>A0A812B626_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_11357</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000375">
        <property type="protein sequence ID" value="CAE1171021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B626"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="327"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="363"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1171021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="422" mass="51746" checksum="DB4B7B78EF441244" modified="2021-09-29" version="1">MFSFFFFFFFLSFVFFFFLSFIFLSYFSFPSHLINLPFFLFSFLSFFSFFLSFFLYFFYFPSHLINLPCFFSFFFFFSFFLSFFIFFHFFHVFLYFPSHFFQPSIFFIFLSFFSILFNHPSMFSFFFLSFFLSLSVYLIIFFLLRLLTFSFFLSFFLSFFLSYFFRHHTFLSSFVCLPHYLFLRLFFLSFFLSFFLSFFVHLPCYNSFSFYLLMRAIFLFIFFCQSHLLSSILSFFSIVLSFFLSFFSSFSFFVFYPRFLSFIVHLPCYLSFSFLPANLSFFRRLFTSLSLIFFFVCPFFLSFFLSFFIIFFFLLSLFRRLFTSLSFLFFFLCQSHFLSFSIYLAIFYAYVNYLSIFFLSLSIFFLCQLSFFCPFLLSLLSFLYIFLPSFLPSFLPSFLPSPRRFLSHYSSNLFIFFADLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B809</accession>
    <name>A0A812B809_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_12642</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000423">
        <property type="protein sequence ID" value="CAE1173472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B809"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1173472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="210" mass="26156" checksum="D11C19EE70CD0320" modified="2021-09-29" version="1">MLDTFRCSQVRSLFLFFSSFAYYHRCFSFPPFLAQLFLSFFYYICYHFFVFSCDFFFHSFSLVSYFSLFLRFFLVFFFLFVYDLFFLFVILLFHFFVRFFLALMFFSFPSFLFFLLMFLIISFFFFFFLIMIFSFLHFLLLHLFLLSFPDVLFFYFTYFFYPTICSDVSTFSFLFSFTCSFIFPFVFCSFIYFFSHISYVISLFLHLFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B8G5</accession>
    <name>A0A812B8G5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_12851</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000430">
        <property type="protein sequence ID" value="CAE1173920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B8G5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1173920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="244" mass="28356" checksum="24939E8B6B000AAD" modified="2021-09-29" version="1">MDCFSRFFFFSTTLNVSSFFFSFTYSTCIFIFFSFLFAFPFSHHFPFFSHHSLFFSHHSLFFSHHSLFFSCYITTSLAASTYLKYADKSSDAVKTFGYGQEGSVKHRFLSIYLSIYLSAFIVKHIFLFFLTLSPINLIYLQSFLFALFFILKLLRIHYFALPFSSHSIFLPSFLPSLFVLFFLPSLLSSFSSFFLVFFLPCLLSSLSSFFFPLFLPSPLSSLSSFFLLFSFSSFFLVSFSAKNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BA76</accession>
    <name>A0A812BA76_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_13117</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000436">
        <property type="protein sequence ID" value="CAE1174472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BA76"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="158"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="274"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="306"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="342"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="370"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="114"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1174472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="393" mass="47036" checksum="9FA8A5CF13891209" modified="2021-09-29" version="1">MLSIYLSIYLSIYLSIYLSIFMSIYLSIYLSHKFIIFPSVYFSFFLSFFLSFFLSFFNLHFLSFFLSFFLSFFLSFFLSFLRLFKNFVKNTDSLYIFQDHNEHGHFRPRFPRPDGHLDRKLNELEDQIIKLEKKIDILVMGINKNGKSQNIFPQIPSFIPFSFLSIFLPFFLISFFFPFLLFVLLPSFFFLLYHSSLLLSFFLFLISSLFFLSFYSLLFLSFFLSFFLSFFLSFFLSKYLYLFGNLSIYLSIYLTLFIYLSIYLSISLCSYLSIYLTLFISIYLSIYLSIYLSITLYSYLFHFVHIYLSIYLSIYLSISLCSYLSIYFTLFISIYLSIYLSIYHSLCSYLSIYLSIYLSIYLSITVSVHIYLSIYLSIYLSIYLSIYLSINSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BDL2</accession>
    <name>A0A812BDL2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_15491</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000539">
        <property type="protein sequence ID" value="CAE1224764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BDL2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1224764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="167" mass="18796" checksum="56151B7D9129E0BF" modified="2021-09-29" version="1">MIYSSIYLSIYLSMTDLSIHLSLISLSLSLSIYVRAITPNYNITFTIMGQGIGGRDFSPPTSKQAENQWKKRRHCRIDIEPKGYQIESDNNGVIAVVAVVAIVRFSLSLSLSLSVSHSLTLYVCIYLSICSCLNQYIYLGLFIYIYINLFISYYLSFASLLSLSLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BES5</accession>
    <name>A0A812BES5_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_16154</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000565">
        <property type="protein sequence ID" value="CAE1226740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BES5"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050525">
        <property type="entry name" value="ECM_Assembly_Org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020:SF20">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00453">
        <property type="entry name" value="VWFADOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032376523" description="VWFA domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="79"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="294"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1226740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="574" mass="64339" checksum="1665A6C16DB14E82" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BJ74</accession>
    <name>A0A812BJ74_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_17676</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000632">
        <property type="protein sequence ID" value="CAE1230338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BJ74"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1230338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="215" mass="24741" checksum="E8E1AAE9289D5F98" modified="2021-09-29" version="1">MSAIFFIRYVSYFFFRYVSHFVSFVMSAIFSFVMSAIFFLPSVNILSIYLSIYLILFISIYLSIYLSMYLSIYLSIYLSIYLILFISIYLSIYLSIYLSNSVHIYLSIYLSIYLSIYLSILAFCHITFAVRHLVSGSRLLHPLKNPRSPCCHAIVTTSATLTLPCEKISSPFLVSVMLDRSARLDPPLFDAVIRLLCNQNARAGRERVGDIPIMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BKV9</accession>
    <name>A0A812BKV9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_17420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000621">
        <property type="protein sequence ID" value="CAE1229737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BKV9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1229737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="172" mass="20410" checksum="4EACAD17CFF01538" modified="2021-09-29" version="1">MITKTFRPDSEIYQNLPIFVHLSIYLSIYLSIYLSIYLCEVETIFNQFFLSFLISHLSIYLSIYLSIYLSVCFFQYEYLLISHSFTLAKENILTNSFFLSFFLSFFLSFFFLSFLISHLSIYLSIYLSIYLSIYLSIYLSMPISFFLCLIIVIYPRLFIIANSSFSVTYVCM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BLD5</accession>
    <name>A0A812BLD5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_18851</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000680">
        <property type="protein sequence ID" value="CAE1233138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BLD5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1233138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="191" mass="21918" checksum="CB129E4C776A0915" modified="2021-09-29" version="1">MQNAVLAVADTLFLFLTFSFSLVFSQSLSFFFFLSRFLSLSFCFCLFLFQSFSSAFIFSILFFFLSFSSSLLFSQALSVFLFSSSLVFSQSFSFSVFFFFTPFFSRSFCFSLICSSLVFSHSLSASVFFFLSRFFLTLFLFLSFSSSFVFSHSLSVSPLFSSSLFFSQFLSFSFPSHLRSPSFSFCHFLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BTF9</accession>
    <name>A0A812BTF9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_23696</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000877">
        <property type="protein sequence ID" value="CAE1243216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BTF9"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1243216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="282" mass="31682" checksum="02516AD55B2F072C" modified="2021-09-29" version="1">MFIQAATIISHMLRHMPSNIFKSISRSHGVGIFSRFESVAVYPEFAHLADRPECRGNCKGNCRSTCSGDGRKFSSLGGLASSIAVCLEDIVMCSANDPYGHKENILIHEFAHTIRIYLPHDLAKRADAAYTQAKRLRLWTKGNYPYAMSNFQEFWAGATESFFMTTSRLDFTGGMNMSLLNSYLSLSLFLTFPQFDSVFKRTISLSLSNYIYVAFKKLSFLSLSLSLSLFLTFPQFDSVFKRTLVLSPSLIIFRSLLKNYLLSLSLSLSLSLSLSLSHFPSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BUP0</accession>
    <name>A0A812BUP0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SERGEF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SPHA_27296</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001053">
        <property type="protein sequence ID" value="CAE1250868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BUP0"/>
    <dbReference type="OrthoDB" id="10256179at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF8">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HERC2-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="RCC1-like" evidence="4">
        <location>
            <begin position="2"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="105"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="166"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="220"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="277"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="334"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAE1250868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="385" mass="41379" checksum="E6FBA98F5B73965D" modified="2021-09-29" version="1">MKVFSWGANSHGQLSQGHTEDLVLPTELLSCPVSASEIASITGGGGHSLLVTKNGHIYSSGSNDRGESCGETKVKLNFTEIFFSSHRIVQATCGWDFSLALTDNGQVFTWGSNSFGQLGVSYITKSSCPVEVFIGETDSNLDQQIPSPVTQVAAGIRHCVVLTENNEVYTWGAGRKGQLGFLDSDKCLSKSEKPVKLTGLKNPVQVIAGSFHSGVLTDTGGIYIWGCNKYGQSTQLKSKMLPLPTEIPVNNFPLLTDDFIKELHSGWSHLLVLTKNCQLISWGRCDYGQLGRPVLQTANGGNYDPIPQTIKALDKCVCKVFCGAEHNIVIVAGGKLLCWGWNEHGMCGNGDEINQPTPVPCLIADEFHTLTAGCGTGHSFAIVNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BWH1</accession>
    <name>A0A812BWH1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Rnz</fullName>
            <ecNumber evidence="1">3.1.26.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_24273</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.11" evidence="1"/>
    <dbReference type="EMBL" id="CAHIKZ030000904">
        <property type="protein sequence ID" value="CAE1244376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BWH1"/>
    <dbReference type="OrthoDB" id="527344at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042781">
        <property type="term" value="F:3'-tRNA processing endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46504">
        <property type="entry name" value="TRNASE Z TRZ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46504:SF2">
        <property type="entry name" value="TRNASE Z TRZ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1244376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="377" mass="43237" checksum="7F91CC12C751458C" modified="2021-09-29" version="1">MLKKHEVLSFASKTKSAGRIYKRNLHQDLCLTLTRRRETVRHLNDEDHFFFLNRRGFHTSKPSLTIAKKKAGSIIPSKSSPSLRGWLTLEGYRIYPWSISGLETCVVINAEDDKKLAVTFDIGYTTRPSVRCQQVFISHGHMDHVSGLFQHATKRSLYNLSPAVYYVPPNLVETLRNVGKQLHSLSGTPDILLDLDIRPIQPGDSVLVTPEYEIRPFATFHRVPSQGYLLYHRYKRLKPLYRHLRPKEIAVMENQCREENIYEVSWLPEVAFTGDTTFELFLNNPPADLLKVRVLILEATYLENVTPGIVRKARERGHTHLSEIIDHAHLFSDVERLVLIHLSDKYSSSFARDAVSFQMPPSLLNKVVIATLAKDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BXP3</accession>
    <name>A0A812BXP3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_24675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000924">
        <property type="protein sequence ID" value="CAE1245308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BXP3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1245308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="218" mass="26702" checksum="A8D9A72B8FF225FF" modified="2021-09-29" version="1">MRGKIIFLLCCCVFSLLHFQLYTFYFFFIHNYIFLSFTHIYLFFLSLFTSIFSLFSSILSLTHISFFSLSFFTYFSHLILSFFTYFSHLIFFFTSFPHFSLLFFPSFPHFFLFFTSFPHIFLLSFSILFRFLLSFLFHFFSTSLSSFFSFSLLFHISFFLLFFFISFSHFFLCFFTSFLYFFFLHFSLFLYLLLLTHISLFFVSFSPFSLSKFLFLYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BZ20</accession>
    <name>A0A812BZ20_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_26245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001002">
        <property type="protein sequence ID" value="CAE1248698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BZ20"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1248698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="160" mass="18581" checksum="545606062DA0A282" modified="2021-09-29" version="1">MTIYHESKLRVTGKFSFLLRKFKRKHSFLSFSFSNKLSIVAFFFSNKLSLLPFPLTNKLSLLSFPLLKTITLSFSITKQIFTHSIFLVKTKCLTEAVTLSFQFVKQIITRCFSIHKQIITLTFLLSNKLSLLSFQLPNKLSLILFFLLKNMPDQSTHSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BZ67</accession>
    <name>A0A812BZ67_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_25395</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000960">
        <property type="protein sequence ID" value="CAE1246866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BZ67"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56935">
        <property type="entry name" value="Porins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1246866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="218" mass="23191" checksum="CD41FA59C188ABEF" modified="2021-09-29" version="1">MLAEILIPSSLSLSIPSFSLSSNSLFSLSLQFPLPLSLSLLQFPLSLSSQFPLLSLSQFPLLSLSPIPSSLSLSLQFPLLSLSIPSSLSLSPILSLSLNSLFSLSQFPSLSPIPSSLSLSLSIPSSLSPLSLSFSYSLTSSLSLSFSYSLTSSLSLSFSYSLTSSLSLSFSYSLTSSLSLSFSYSLTSSFSLSFSYSLTSSLSFSSSSYFLFLSPKKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BZC9</accession>
    <name>A0A812BZC9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_28329</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001112">
        <property type="protein sequence ID" value="CAE1253194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BZC9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="301"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="332"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="362"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="396"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="434"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="465"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="506"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="542"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1253194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="567" mass="66091" checksum="23ABE5A5774B93B3" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BZP6</accession>
    <name>A0A812BZP6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_25864</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000984">
        <property type="protein sequence ID" value="CAE1247848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BZP6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1247848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="243" mass="28344" checksum="EEBB7E6A1C7F376D" modified="2021-09-29" version="1">MGIQLYEDGVDTRIIRDLFQFYLSIYLSIYLSIYLCFSFPLAKKSVHSVFSLCRSLSNSIFSFPLSFPMIFLFSLSLTTYLNIFCCFFLSLSLIYTLPPLYCYKIHCISLLFLFFPTVSLFFHSVFLSNDTFYLSFNFCLYPKHFSLFFPSKQTFYLSLPVNFHSRSLLHKSTHKCKHTPMSAPRRQKSRMFGTFPCLIIIRRRFTTSTFAKSLEIWHSVTFPGSLSSPDAKCTLLRCGFSID</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C1C8</accession>
    <name>A0A812C1C8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_28019</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001102">
        <property type="protein sequence ID" value="CAE1252542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C1C8"/>
    <dbReference type="OrthoDB" id="9635126at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1252542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="158" mass="18720" checksum="A8C3FF21CA7DA3FC" modified="2021-09-29" version="1">MNSTIVFFTPFLYSFFLRLFLSFFLCIFVCSYLSIYLSIYLSIYLSIYLSIFVCSYLSIYLSIYFVCSYLSIYFCLFISIYLSIYLFCLFISIYLSIYLSILSVHIYLSIYLSIYLSIYLSLSVYTYFLLFFIVNLVSLIKLLVPFVSFVIRPPSPFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C3K7</accession>
    <name>A0A812C3K7_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">fumarate hydratase</fullName>
            <ecNumber evidence="2">4.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SPHA_28843</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Farmed</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.2" evidence="2"/>
    <dbReference type="EMBL" id="CAHIKZ030001136">
        <property type="protein sequence ID" value="CAE1254155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C3K7"/>
    <dbReference type="OrthoDB" id="1738025at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01007"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004333">
        <property type="term" value="F:fumarate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006106">
        <property type="term" value="P:fumarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01362">
        <property type="entry name" value="Fumarase_classII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.40.30:FF:000002">
        <property type="entry name" value="Fumarate hydratase class II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.10:FF:000001">
        <property type="entry name" value="Fumarate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.200.10:FF:000001">
        <property type="entry name" value="Fumarate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00743">
        <property type="entry name" value="FumaraseC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005677">
        <property type="entry name" value="Fum_hydII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018951">
        <property type="entry name" value="Fumarase_C_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00979">
        <property type="entry name" value="fumC_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008909">
        <property type="entry name" value="PRK12273.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11444">
        <property type="entry name" value="ASPARTATEAMMONIA/ARGININOSUCCINATE/ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11444:SF1">
        <property type="entry name" value="FUMARATE HYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10415">
        <property type="entry name" value="FumaraseC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarate lyase N-terminal" evidence="4">
        <location>
            <begin position="53"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarase C C-terminal" evidence="5">
        <location>
            <begin position="450"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAE1254155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="505" mass="53784" checksum="7F13C4D0CC30B896" modified="2021-09-29" version="1">MSLSSLIRSSGAVTNPLITRGFTQRIYNKIRVSPLTTNANMGENVRVETDSFGPISVPADKLYGAVTARSLSNFNIGGENERMPVALIKAFGILKAAAASANQEFGLDPKIAAAIKDAAMEVSSGSLTDHFPLVVWQTGSGTQTNMNANEVISNRAIEKLGGQLGSKTPVHPNDHVNMSQSSNDTFPTAMHISVALEINNCLLPGMQKLQAALQTKATEFKDIIKIGRTHTQDAVPLTLGQEFSAYVQQMTNGIERVKATLPRLYELAIGGTAVGTGINTRIGFAEKVAENVAEITGLPFTPAPNKFEALAAHDALVEVHGALNVIACSLMKIANDLRFLGSGPRCGLGELSLPENEPGSSIMPGKVNPTQCEAITMVAAQVMGNQVAVSVGGSNGHFELNVFKPLIVRNVLQSTRLIGDACVSFADNCVAGIQPNRKRLATIMNESLMLVTALNPHIGYDNAAKIAKLAHKEGTTLKEAALKLNLLTEKQFNEIVRPEKMLGPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C597</accession>
    <name>A0A812C597_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_27984</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001101">
        <property type="protein sequence ID" value="CAE1252409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C597"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="284"/>
            <end position="309"/>
        </location>
    </feature>
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        <location>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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    </feature>
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        <location>
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            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="546"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="576"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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        <location>
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            <end position="651"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="701"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="728"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="762"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="786"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="821"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="855"/>
            <end position="884"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1252409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="898" mass="109095" checksum="54D4F64F3F3A3262" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C9T3</accession>
    <name>A0A812C9T3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_32041</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001333">
        <property type="protein sequence ID" value="CAE1260183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C9T3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="12"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1260183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="216" mass="26091" checksum="9A9717ADB07BAB56" modified="2021-09-29" version="1">MSSSSSSSSSSFSFIPLLNFFFFSSYYLEEFFFSSGSSSSSFLLRRKMNLSSSPLFLLLLFFFLLLLLLLRLTFQFLFLFLLLLERNGRSSFNFSNQTLSYLIGFFFFFFFFSSSSSSEGSSFYFFFFFFFFFFFFVNFSFFLYFFINKQGFYIFFFLSLFFFFPTVYSSFFLSSFLPFFLSFSFKTYSLFSNHFDSFFLSFFLFFFLSVGRRYPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CAR1</accession>
    <name>A0A812CAR1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_32486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001356">
        <property type="protein sequence ID" value="CAE1261001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CAR1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <end position="45"/>
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        <location>
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    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
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        <location>
            <begin position="160"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1261001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="192" mass="22084" checksum="CCC9F7A02365F6C4" modified="2021-09-29" version="1">MQTAVRTPHSDRYTNAARACKVNTSALHISIYLSIYLSIYLSIYLSQSVHLFLSLSLSLILSIYPSLFISIYLSIYLSQSVHLFLSLSLSLSHSIYLSQSVHIYLSIYLSIYLSIYLSQSKNLNISLSLSLYLSIPVCNIYLSIYLIIISFYLYNYLYLLLIYLSIPFISYLSIYLSIYLSIYLSIYLSITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CB21</accession>
    <name>A0A812CB21_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_34485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
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            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001466">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CB21"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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            <end position="313"/>
        </location>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1265053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="322" mass="36640" checksum="A0AF708CDBD57050" modified="2021-09-29" version="1">MGTFCFSFTEKFNLSFHFLRRAGDGDTGVLEGEEKLFALPVFVYCWQKGQDCLGKFLYFLCPASPSSSFSFFLFCFIPTVHAEALLPSPSCYGRCYVSCRSHDCYCVCGRCCCYCYFCFFLPFLLQVVLRRGEDCFLPGISCWGVVGNLCPLSHHQFTTISGILGLLRPHRFLSCFLFGLWSGIPTSLDKCPMSVSFLSSRMSYIALLPLHNTLTGMLRLFRASSMVSLLTPKTSWCLHLLLTGRQFSLLLPPGPRISTRAHYRKWTLRTALVSSPNVWHPFSRLYSKLTLFFYLCHIVSHLSLILSVIYLYMPSTPPQWCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CE48</accession>
    <name>A0A812CE48_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_32540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001358">
        <property type="protein sequence ID" value="CAE1261069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CE48"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="34"/>
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        </location>
    </feature>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="352"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="385"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="432"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1261069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="462" mass="55620" checksum="7BFE805392652D8A" modified="2021-09-29" version="1">MILNNKTFFYFLIAINIWNKSLSISFFLSFSLSFFLFHFPIIFFLSFFFSFFQSDNKKRKENEQKTKTNQFLFFIYLFSFFLFHFPIFFLSFYFPFPIFSFFVSSNILFFQISFSFFLSFFLSFFLSLPNVLFGFPFFLSFFLSFFLSFFLYLPNVLLVCLFVCLFLSFFLSFFLFPFSNILFLCFFEYLVFPNIFFFLSFFLSFFLSFFPFLMYCLVFLSFFLSFFLSFFLSFYPIFHFLFLSFFFLSFLPLFLLFFLSLSLLHVFFLSFFFSFFYSFFLSFFLLFFLSFFLILFLLSFFLSFFLSFFLSFLRGCFGLPLYVCLSIYLSIYLSIYLSILSPRFVHMSRIYLSIYLSIYLSIYLSCQLDLSIGHVLFYLSIYLSIYLSIYLSIYLSIYVIAAGASFCIQLSRSRKMAVRPAKSLFFLLLHDLNNFAVTSGISIYLSIYLSIYLSIYLSISHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CF99</accession>
    <name>A0A812CF99_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BLMH</fullName>
            <ecNumber evidence="4">3.4.22.40</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SPHA_36651</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.40" evidence="4"/>
    <dbReference type="EMBL" id="CAHIKZ030001612">
        <property type="protein sequence ID" value="CAE1269578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CF99"/>
    <dbReference type="OrthoDB" id="2666448at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070005">
        <property type="term" value="F:cysteine-type aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043418">
        <property type="term" value="P:homocysteine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009636">
        <property type="term" value="P:response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004134">
        <property type="entry name" value="Peptidase_C1B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10363">
        <property type="entry name" value="BLEOMYCIN HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10363:SF2">
        <property type="entry name" value="BLEOMYCIN HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03051">
        <property type="entry name" value="Peptidase_C1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0788">Thiol protease</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAE1269578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="350" mass="40882" checksum="7E5BD2D1E97E9E05" modified="2021-09-29" version="1">MTENNSICTGIPVEQLDKMKTLNDLTLSPRSLISINHVFNTKIEEGKPITNQKSSGRCWIFAYLNQTRIPFMEKYELAEFEFSQAYLFFWDKLERSNYLLDAFVHYILIYAKRVVYHFGHHSFSPPATITWEYYNKNKVYHKVDKITPLEFYKQYVHPCWDVTEMVCLVNDPRANNAYNKLYTVEYLGNVTNGKHVLYINQPAEQLKKFALAQLQDKKSVWFGCDVGKQFQGKQHGVLDLKAHDYKKVFGCEVQTLNKAERLIYRESLMTHAMLFTGVNVDGEKTDKWRVENSWGDEDGDKGYLVMTDDWFSEYVYEVVIHKKYLPAEILAILDQNPIVLPAWDPMGSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CHY4</accession>
    <name>A0A812CHY4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_33938</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001432">
        <property type="protein sequence ID" value="CAE1263940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CHY4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1263940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="256" mass="29921" checksum="9F0354189457200C" modified="2021-09-29" version="1">MHTPFVSVTVDEEMARHVPFTRSMADDENKEFRANYLAPLLLQHLPNLSSSPSYFFNNPPPSTTFSNLFRIYPPPTTFSITLSFYNLFRICPSPTTFSITPSFYNLFRIYPPPRHFPITPLLLQHLPNLSSSYHLFNNPLILQPLPKLSSSYHLFNNPLILQPLPKLSSSYHLFNNPLLLQPFPNLSSSYYLFNNFLLLQPFLNLSSSYYLFNNFLFLQPFPNLSSTKQLFRIPPPSITYFLYLLVFFKSFFKFML</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CM20</accession>
    <name>A0A812CM20_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_39966</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001879">
        <property type="protein sequence ID" value="CAE1276351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CM20"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1276351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="213" mass="26047" checksum="F983C7CA39F7B7A6" modified="2021-09-29" version="1">MKVFLFHFTAFNVMSTLFFFYISLFLCLLIISFIFFIHFLFQSTFFNTSRFSSHYFPRSSTSVCVSFLPLFYFIHSFFCCLFFFLFSFSFSLSLFILRFHCHFFYSFFIFLHYCVSFFLSFFLSFFLSFFLSFFLSHLFAFFYFNFFTCFNFVFLSLFSPPFCVFLFIFFTSISLFRSFRLLFSFFTLSLLFRFLFYAIHSFTLFLSLSLLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CP02</accession>
    <name>A0A812CP02_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_37478</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001668">
        <property type="protein sequence ID" value="CAE1271925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CP02"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023201">
        <property type="entry name" value="SecY_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103491">
        <property type="entry name" value="Preprotein translocase SecY subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1271925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="157" mass="18938" checksum="7207C98F7C3BEF0C" modified="2021-09-29" version="1">MKRIYFQLTNREVRVQERKRGKKNRYLDRKCNDTLSIIYFFSFNRFFFFQSFLLFFLFDFFTFSFFISYPIFFLFLSFYFFLFCLSFSQFNIFLFSSNARKNNRAKGMAQQTAVGSRENGDNLSSMDDRRTIGQSIPPPPQRHKLFIFLSISTALWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CSV1</accession>
    <name>A0A812CSV1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TTC21B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SPHA_39538</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Farmed</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TTC21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001845">
        <property type="protein sequence ID" value="CAE1275560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CSV1"/>
    <dbReference type="OrthoDB" id="10259630at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030991">
        <property type="term" value="C:intraciliary transport particle A"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035721">
        <property type="term" value="P:intraciliary retrograde transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061512">
        <property type="term" value="P:protein localization to cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056832">
        <property type="entry name" value="ARM_TT21_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056833">
        <property type="entry name" value="ARM_TT21_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040364">
        <property type="entry name" value="TTC21A/TTC21B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14699">
        <property type="entry name" value="STI2 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14699:SF0">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 21 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25060">
        <property type="entry name" value="ARM_TT21_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25062">
        <property type="entry name" value="ARM_TT21_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Tetratricopeptide repeat protein 21A/21B N-terminal ARM repeat" evidence="4">
        <location>
            <begin position="3"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Tetratricopeptide repeat protein 21A/21B second ARM" evidence="3">
        <location>
            <begin position="135"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="190"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAE1275560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="412" mass="46883" checksum="ECED4E092F4158F7" modified="2021-09-29" version="1">MNDQNKQILALKGWIELASGKDPQAKKAYKYFDEAMQIASNCEMDIILGMCQCLMLRHNFKKALELINQLIVAYSDLLPGFEEKMKLLLALKDWEQVTDTASRALDVDQFCIEALCYLTLYNLCRVGDYNEAHNYLSKLLNSLDMFEPSSKSLYYNIARLISRVCGRNELILQQTHTLAQRAIEEESCEADYMRELGYQLVLRGKIKEALECYKHTIKLDETNLPAVTGIIECQLIQNKLDDAAQQLEFLSEIQMSIGKTSELYYLSAVLAKKRNKGEENIVVLLNEAIEKHFSTLKNYYLGVDYYIMLNPDFLILIVKDYLNYAPQQPLQHGQAMDPILRKCQQVLDPLIKAAPGLIEGIYLMGKVKFLSGDFESAQMTLQHCLEQDQALSDAHILMAQVNANTSLIISGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CSY8</accession>
    <name>A0A812CSY8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_41128</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001968">
        <property type="protein sequence ID" value="CAE1278229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CSY8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1278229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="268" mass="32016" checksum="8DD496362812DEAE" modified="2021-09-29" version="1">MSSFILLFLCLFTSIYLSIYLSIYFVFVLSIYLSIYLSIYLSIYLIEIIALCHYSLGEINAESIWLSIYLCIFSVYFCPYLCIYISHSANIYLSIYLSIYLSALLLIFISIYFLYLFSIFISSIYLSICFILYSYLSIYRTMMKLVLKLNAKKRFVCQIPRNFFPHYVYVIYLSIYLSIYLSIYLSIYLSQSFHIYLSIYLSIYLIYLFYLSLSYLSIYLSIYLSIYLSIIYLYLSIYLSLSIYLSIYIYLSIYLSIYLCVNVFNLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CTE7</accession>
    <name>A0A812CTE7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_39765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001868">
        <property type="protein sequence ID" value="CAE1276061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CTE7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="321"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1276061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="430" mass="51533" checksum="8C58F384619EB13C" modified="2021-09-29" version="1">MSLIFLCFSLSTLYSSFDIFSSLSPPFILFRALFFSLYSLPSFFHSFFLSFLTNNPSLIAFSFYFLLFIFLPLLFVFLNLLLNHNSSSITTFFFLSFLTNNPFYLLFSFFSFPFFFFHFSPSSIFSFPFFSFFHLLFVFIFFHFSPSSIFSFPFFSFFHLLFVFIFLSYVPFRFFYSPSHTTFGSCSHNILSLFLSVLTFFTCFFSFIFHFSSSFIFLLFFPFIFLSFLFVFFNSPFHTTFKQLSFLLLSILNSNLFYLFFFFYFIFHFSSTFISFLLSFLFYFASFRFFSYFVLPSIQHSTPIHTTFFFLFLSIPTNNPFLLDFFSIFLPVFFSFFLLLFYFPFVPYPFFLSTSYLSLFHLFFSPIFSPRLPPRLFFHKHNIFPPIRNSALISSQFLFFDFSTFPPAAIIAQRRRRMSCNVSVFGARWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CUL5</accession>
    <name>A0A812CUL5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_40883</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001944">
        <property type="protein sequence ID" value="CAE1277819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="340"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="383"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="412"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="438"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="476"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="516"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="549"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="582"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="659"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="682"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="716"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="750"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="811"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="844"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="875"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="904"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1008"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1061"/>
            <end position="1085"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1277819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1578" mass="180266" checksum="649ECD9BED4AACA7" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CUT3</accession>
    <name>A0A812CUT3_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Flavin-containing monooxygenase</fullName>
            <ecNumber evidence="8">1.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SPHA_41981</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Farmed</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the FMO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="8"/>
    <dbReference type="EMBL" id="CAHIKZ030002028">
        <property type="protein sequence ID" value="CAE1279811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CUT3"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000138">
        <property type="entry name" value="Flavin-containing monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000332">
        <property type="entry name" value="FMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00370">
        <property type="entry name" value="FMOXYGENASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0274">FAD</keyword>
    <keyword evidence="3 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAE1279811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="433" mass="49267" checksum="A6F4A8AF0C3B59A2" modified="2021-09-29" version="1">MKVAVVGCGAAGLCVLRHLTTPKKNDLSGLIDFEAVGFEQAPQIGGTWVYSPSTGYDAYGLPVHTSIYKNLRTNLPKDVMCFPDFPYHPDLPSFLHHSDVRAYLEDYAQHFHLLKHIKLQTKVELVELVPGSDGSQNSVKWKVTYKKVSDNSKEDNNMISDVFDALIICNGHYSVPYIPEIKGKEIFKGVIIHSHDYREPEMFVDKTVVCLGAKSSGIDISIELTAHANKVFLSHRRQPLQAEFPENLFQKPGIRELTSDGVVFENGEFHHIDTLILCTGYKINFPFLHENCGVQTKYNRVTPIYKHLINIDFPNMAIIGLCMNITPLPLFHIQASFVKAVLLGKIALPTADEMRKDEQEDFDQRLRDGMAKHHAHVLGEKQWNYNNEMATICGCELLPKHFEDIYKFVHIKRSRFPAKYKEMDIDVAHENML</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CW54</accession>
    <name>A0A812CW54_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">KDM1B</fullName>
            <ecNumber evidence="2">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_43018</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="CAHIKZ030002130">
        <property type="protein sequence ID" value="CAE1281704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CW54"/>
    <dbReference type="OrthoDB" id="2219495at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF410">
        <property type="entry name" value="LYSINE-SPECIFIC HISTONE DEMETHYLASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="1">
        <location>
            <begin position="10"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1281704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="301" mass="33423" checksum="F899FE94EEC38469" modified="2021-09-29" version="1">MELVSGCSVEELSAMHWDQHEAFPQLGNSSILLSQGASQLLNLLSEDLDIQYNVEVVKIDYSGMGVIVHASSGGVFKADKVLVTVPLAVLQNDIIEFVPPLPAEKTKAIKSLGAGVVEMVVLQFKRNFWKEKVKDVDVFGHIASDESSRGLFSVFYDLSRVHKSGKESHILVTYIAGNGLKKMFGKTSKEIVDACMKVLYKLFPEQNVPEPNAYYTSHWKNDRFTRMSYSYIPVGVDASVYSHIAQEVEEKVFFAGEATCCQFPQSMSGAYWSGLREAEKILDSLECSKIATDSTFLHSVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CYH3</accession>
    <name>A0A812CYH3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_45617</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002357">
        <property type="protein sequence ID" value="CAE1285796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CYH3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1285796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="219" mass="24136" checksum="1B1132DE38A9A485" modified="2021-09-29" version="1">MQITHHSLSLPLCLSLSVTFSFSSSLSLSLFSLSLSLSLSLTLCLIFFLFISLFLSSFSFIFSVYLCLSLLVFFSLSLSLSVSLSYSLYLSFSPSLSLSLSLFPFLSLYLSFSPSFFLSLCVSFSLSLSFSPLFSFFLSLSLSVCFIFLLFISLSRLLFLSLSVSFSFLSLSFSLSLFIALSLSVSFSFSLSLSFPFSLSLSLPLSLLPSDSSMPHTFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CYI7</accession>
    <name>A0A812CYI7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_43232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002157">
        <property type="protein sequence ID" value="CAE1282092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CYI7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1282092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="171" mass="20854" checksum="5DDE063CBC6B2EE4" modified="2021-09-29" version="1">MTVFVSFFVSFLICRCLLSFFLIVYQHDFFLSFFFLSFFFLSFLTPIFLFLSPLTFSFLSFIYTIVVYFLSFSFSLNTFSFFFHILYHSFFLNSHFFSFRLNYRFCLFLSFFLFSLHFLPNLSFFLSVFLSFFLSFFYTLSMFIFFFFDVLSSLFSSFFFFLAFFLSISLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CZC5</accession>
    <name>A0A812CZC5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_44618</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002280">
        <property type="protein sequence ID" value="CAE1284148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CZC5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1284148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="216" mass="25600" checksum="088410694145FECB" modified="2021-09-29" version="1">MTDGVLSESRTSLDPPVSDRELAFPFTFIPFSISSPHPPLSFRACYITQANKTGEMGHFSPSECAKHKTEILRPLLSFYVAPPSPSLTYSLDSVLFLFCLSIFFFLFFFFIQYFHSFSFLFFLRFFFVFVLYFFFFVIFLASLFLVNFCLHFGLTMLSFLLHFFFIFFFSFSFYYSLLLYFVFPFLPLSNFVLNSFYFPSSFFVSFLFCFYLSFHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D123</accession>
    <name>A0A812D123_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_48130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002655">
        <property type="protein sequence ID" value="CAE1290289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D123"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1290289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="173" mass="20570" checksum="7452B611FD04DF50" modified="2021-09-29" version="1">MIPLLILIGLDVNIYLSIYLSIYLNLFISIYLSIYLSIYLSIYLSIYLSISICSYLSIYLSIYLSIYLNLFISIYLSIYLSIYLNLFISIYLSIYPKFFLIYQSIYLSIFFLSIYPNIFPNYLAIQIFSFCPSTYPNLSIYLSIYLSIYLSIYIYIYIYIYKTFPTQSVYLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D373</accession>
    <name>A0A812D373_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycogen debranching enzyme</fullName>
            <ecNumber evidence="5">2.4.1.25</ecNumber>
            <ecNumber evidence="6">3.2.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Glycogen debrancher</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">SPHA_45304</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">Farmed</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>Hydrolysis of (1-&gt;6)-alpha-D-glucosidic branch linkages in glycogen phosphorylase limit dextrin.</text>
            <dbReference type="EC" id="3.2.1.33"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan to a new position in an acceptor, which may be glucose or a (1-&gt;4)-alpha-D-glucan.</text>
            <dbReference type="EC" id="2.4.1.25"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the glycogen debranching enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.25" evidence="5"/>
    <dbReference type="EC" id="3.2.1.33" evidence="6"/>
    <dbReference type="EMBL" id="CAHIKZ030002334">
        <property type="protein sequence ID" value="CAE1285189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10248904at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004134">
        <property type="term" value="F:4-alpha-glucanotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004135">
        <property type="term" value="F:amylo-alpha-1,6-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005980">
        <property type="term" value="P:glycogen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11327">
        <property type="entry name" value="AmyAc_Glg_debranch_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000070">
        <property type="entry name" value="GDB1p Glycogen debranching enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000108">
        <property type="entry name" value="glycogen debranching enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010401">
        <property type="entry name" value="AGL/Gdb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032788">
        <property type="entry name" value="AGL_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029436">
        <property type="entry name" value="AGL_euk_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032792">
        <property type="entry name" value="AGL_glucanoTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032790">
        <property type="entry name" value="GDE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006421">
        <property type="entry name" value="Glycogen_debranch_met"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01531">
        <property type="entry name" value="glyc_debranch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10569">
        <property type="entry name" value="GLYCOGEN DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10569:SF2">
        <property type="entry name" value="GLYCOGEN DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06202">
        <property type="entry name" value="GDE_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14701">
        <property type="entry name" value="hDGE_amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14702">
        <property type="entry name" value="hGDE_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14699">
        <property type="entry name" value="hGDE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="14 22" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="9 22" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 22" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 22" id="KW-0808">Transferase</keyword>
    <keyword evidence="17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="55"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1409"/>
            <end position="1432"/>
        </location>
    </feature>
    <feature type="domain" description="Eukaryotic glycogen debranching enzyme N-terminal" evidence="19">
        <location>
            <begin position="156"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Glycogen debranching enzyme glucanotransferase" evidence="20">
        <location>
            <begin position="252"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="domain" description="Glycogen debranching enzyme central" evidence="21">
        <location>
            <begin position="825"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="domain" description="Glycogen debranching enzyme C-terminal" evidence="18">
        <location>
            <begin position="1205"/>
            <end position="1406"/>
        </location>
    </feature>
    <feature type="domain" description="Glycogen debranching enzyme C-terminal" evidence="18">
        <location>
            <begin position="1558"/>
            <end position="1764"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00020723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF06202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF14699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF14701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF14702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="CAE1285189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1828" mass="210005" checksum="795E5CF44CAA87FF" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D3I3</accession>
    <name>A0A812D3I3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_45408</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002337">
        <property type="protein sequence ID" value="CAE1285406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D3I3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1285406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="248" mass="28802" checksum="25A6C6B83727C6C7" modified="2021-09-29" version="1">MSVYYIGDLKPNTHQCSSCKTLIYLSIYLSIYLSIYLSIYLFQSVRIYLSIPLSITLLKEKHDVILKDEQIILYQASFSSNDKIEFLLLVIFFYLSIYLSIYLSIYLSHGLFNVDNIFIAGNIFYLSIYLSIYLSIYLSIYLSQSSSSGLSSFFVKLYFSHHLLGRSLSFIDIINLLPEGKAKHLQDFIISPRTRFLLLVIFCIYLSIYLSIYLSISPQSIDLTPNLSIYLLSIYLSIYLSIYLYPMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D3K4</accession>
    <name>A0A812D3K4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_49330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002811">
        <property type="protein sequence ID" value="CAE1292565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D3K4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1292565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="158" mass="18496" checksum="A29EAF3C5F438F9D" modified="2021-09-29" version="1">MFSFACSRLTLTSIRIYLSQTLRIYLSIYLSIYLSIYLSRFKSIYLSIYLSYLLFLSIYLSIYLSIYLSIYLSICFLSIDHSQPVPLNLSLYLSIYLSIYLSIYLSIYFCVHIYFSISLSICLSVFISMYLSLPYLSIYLSVFISIYLSIYLSISLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D3X5</accession>
    <name>A0A812D3X5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_49493</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002841">
        <property type="protein sequence ID" value="CAE1292866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D3X5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1292866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="206" mass="24241" checksum="D752B68178548008" modified="2021-09-29" version="1">MKRSKSLYLALSLSALLIGLSLSHSHNLFLTLTSLPSFLPSFLPSFLPSFFSSFFPSFFSIANHLFNLPYLLSDKFHVFYSASDQFHTVFFPFFFYLSVPIYNNPLFHFHGSRSIFFKSDASSVIFSLLPEICIIFFVFFINFSFFLSFFLSFFLSFFLSFFLHASLSYIYLYLYFTKGRKKFLSFFLSFFKSLFFLLHLMPAFAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D404</accession>
    <name>A0A812D404_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SPHA_46208</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bZIP family. Maf subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002434">
        <property type="protein sequence ID" value="CAE1286806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D404"/>
    <dbReference type="OrthoDB" id="5974330at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14718">
        <property type="entry name" value="bZIP_Maf_large"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000011">
        <property type="entry name" value="Transcription factor MafG, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004826">
        <property type="entry name" value="bZIP_Maf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008917">
        <property type="entry name" value="TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024874">
        <property type="entry name" value="Transcription_factor_Maf_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10129:SF44">
        <property type="entry name" value="TRAFFIC JAM, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10129">
        <property type="entry name" value="TRANSCRIPTION FACTOR MAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03131">
        <property type="entry name" value="bZIP_Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47454">
        <property type="entry name" value="A DNA-binding domain in eukaryotic transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="9">
        <location>
            <begin position="188"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="39"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="112"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="39"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="127"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAE1286806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="268" mass="30466" checksum="350ADC556A3D620B" modified="2021-09-29" version="1">MDSTHHLADEYITDFDLEQLEMVSSIKMEADKDRFSNTCCGNMSEYSQSAPTSPEDGETSSMSSSSPDVGHGLQAPVKNFMEEIYWFTNTHNVHDIPQNGVLDLFLNNNSSPLPNTGSTRTQSRKNSTSSMSSSASASSSSMCIKRNFKTRSSPDLSKCELNDDELVSLPVRDLNKRLHGFPKDEVSRLKQKRRTLKNRGYAQNCRSKRMQQRNELERTNKSLQQQLSVIQRQISQVTRERDYYKECLERLQRKRDGSISSSPSSLTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D437</accession>
    <name>A0A812D437_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_47047</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002523">
        <property type="protein sequence ID" value="CAE1288246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D437"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="328"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="358"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="393"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="417"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="442"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="469"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="504"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="530"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1288246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="559" mass="67487" checksum="5E6EE9A0CC077A40" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D4N6</accession>
    <name>A0A812D4N6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_46055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002410">
        <property type="protein sequence ID" value="CAE1286484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D4N6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1286484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="271" mass="31813" checksum="8F282EE3FCA33EE9" modified="2021-09-29" version="1">MIYEYLSEFGHIYLSIYLSIYPYMQIFLSYRSCLFSAFNTSAHFSLIFFSLSSTLFSLHIFSSPSFLSMLFFFSVLFSLLSFLLSCYSLFSSSLFVLVFFALYSSLFFPLLFSLFCSHLFSVFFSILRSFFLFALFFSFCSLHFSFFSFFFVSAAFSSLFLYLLSYLLLAFFSSPCLSLHFSFFFSFFSFLRIFFLLSSFSPLFSPIFSSLFSLFRSFLFSALYSSLHFSLLHSFLLSVLFSSLRFPRTFQNCNHETINNKVVTIIENVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D4V0</accession>
    <name>A0A812D4V0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_47530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002578">
        <property type="protein sequence ID" value="CAE1289176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D4V0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1289176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="213" mass="25236" checksum="E8DE33B165167699" modified="2021-09-29" version="1">MYVCIYLSIYLSISLANSFNYLSTYLSIDVPHSLHIYTILSVCQFVCLYLSIYLSIYLSIYLSIYLSIYFFIYVFFFVISLSISIYLFIHSIIYLSIDVFFLPVFFCSASMYLLSIYLSIYLSIYLSILLSICFTSVLTIFLSIFYLFSLYICLTIFFFCFFLSFFSFFLSLSIYLSIYRSIINLLYICLTIFLSLFSLPFFPYLSIYLSIYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D5A2</accession>
    <name>A0A812D5A2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_47347</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002556">
        <property type="protein sequence ID" value="CAE1288765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D5A2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="307"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="355"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1288765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="393" mass="49451" checksum="8CB6EFE2DD870084" modified="2021-09-29" version="1">MKCVTYNLSIYLSIYLSIYLSWFFTKFFLSFLFVCYSLHFFCLFFHKFYFSLFLFCAQFFFFHFSFFLISFLFFLFIQFCFFSFISLVSSILFYHFIFFFFFLLNFFLPFSFYPFFFYFFVCYLYFFFHYFSSFFLSNFFYFLLIFFFLFFLFVFLHFLSFFLLFINLLLSFIVFIFFSYYYFFLPLFLSIFFFFIFINFLLLPFSFFTLFSIYFFFILFSFFLFLPSFYFLISLDFSILFFIIFIFLSFLLIFFSLTFVFYCFLLYFFSFLFSSFLFFVLFLTYFLFTTFFISFKKISFFISFLHFTFFFNLIFLFFPFKFFIFSSSFHIHIFYPHFSFFHSQKKLSLSPIPSLVIYFFFSLFTITFFLSHPFSFSLDITYFFFFSLSRLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D7I9</accession>
    <name>A0A812D7I9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_51252</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003097">
        <property type="protein sequence ID" value="CAE1296123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D7I9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1296123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="228" mass="26104" checksum="6C33B885BDB2CD8C" modified="2021-09-29" version="1">MGGTGGGENFCLFISLLMVLFKYLLKSISIYLSIYLSIYLSIYLSISDQRIYLSIYLSIYLSIYLIVFSSFLNPYFHFLSSHYKFFLLTFPLSSHHSPFFFHFHSSSSPLLLLLLLLHISPVSTKATSSSLSPDLSFFYIPLLSLSLSYSSSPLHFSTFKEWNDNRCIYCSSDICNRTTQSLKHLTEKYINYLDLSICLSIYLSIYLSIYLSISVCPSLTLSCSLSLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D7T9</accession>
    <name>A0A812D7T9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_48029</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002655">
        <property type="protein sequence ID" value="CAE1290295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D7T9"/>
    <dbReference type="OrthoDB" id="5860362at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="295"/>
            <end position="320"/>
        </location>
    </feature>
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        <location>
            <begin position="469"/>
            <end position="485"/>
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    </feature>
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        <location>
            <begin position="491"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="517"/>
            <end position="538"/>
        </location>
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        <location>
            <begin position="550"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="583"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="610"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="636"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="675"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1290295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1172" mass="135188" checksum="BF3AE957EB324566" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D956</accession>
    <name>A0A812D956_ACAPH</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_51651</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D956"/>
    <dbReference type="Proteomes" id="UP000597762">
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    </dbReference>
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            <end position="73"/>
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            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1296818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="172" mass="19900" checksum="6874DC4216B21FDD" modified="2021-09-29" version="1">MTIFLFSHNHTLFDSSVYSSFDKSFNIFLLLSFIHNVFISITLFLCLSVCLVFSFLVSHFLLWFLLYYVLFLLRSTASRAYHSSFLKSHIAPSLSLSLCRSHLRYKIIIDLLCLVFLSLLYLLSFTHTVSIMSIFTLVFLSFSLSLFLSLSLCFRVEAFKSHSKHISLPSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D9Q6</accession>
    <name>A0A812D9Q6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_49774</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
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            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="CAE1293379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <source>
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        <source>
            <dbReference type="EMBL" id="CAE1293379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="249" mass="29189" checksum="3A65523102F1C29E" modified="2021-09-29" version="1">MLIICLSIYLILLISIYLSIYLSISFCSYLSIYLSIYLSIYLSIYHSSAHIYLSIYLSISFCSYLSIYLSIYLSIYLSIYLAYVCLSVCLSVCLSIYLSIYLSILVCIHLCLFFFSYLYTIKSVIYLSISYFPFAFIYFYTFAKHPCSLSQRSFIIFRLKNTTNLNLFLGVLCWDLPLLFCFISNKNYPFTLSVLSIYLSIYLSIYLSIYKYLLFSLTVLIYLSIYLSIYLSIYLSIYLSISTHPFFQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D9X1</accession>
    <name>A0A812D9X1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TADA2B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_48541</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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            <taxon>Decapodiformes</taxon>
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            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002711">
        <property type="protein sequence ID" value="CAE1290998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="270417at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
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    </dbReference>
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        <property type="term" value="C:nucleus"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:SAGA-type complex"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055141">
        <property type="entry name" value="TADA2A_B-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12374:SF63">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 2-BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12374">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTOR 2 ADA2 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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            <begin position="24"/>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1290998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="276" mass="32269" checksum="58B34F4E53FA3EEF" modified="2021-09-29" version="1">MHGAEIGQHKRYHCYKIRYPSPDGPFSTSDPWTLTEEHLLLYAIDDFGYGSWDDCARLVSGKTPEECRRHFETFYLGGVAGRMFFPKNKPSTAVEHPEHKNDINTQECQILLREAFKLIGFSSKRDEFEIEYDNFAEAAITLSVAHLDYETISHEMEDMDTEFKLARLDHYRRRLAERERRKRLVIDYGLIGLFSQKAISLDIIVHDSFPLAMQRGNNASIAFQKLLPFKTFREFFASLHKVNILTAEIQKLQEYRLNGLTRINEIIPFQIARSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DA53</accession>
    <name>A0A812DA53_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_52525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003280">
        <property type="protein sequence ID" value="CAE1298336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DA53"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="169"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="194"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="279"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="308"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="337"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="371"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="441"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="466"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="493"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="523"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="553"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="584"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="610"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="645"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="679"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="708"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="761"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="789"/>
            <end position="815"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1298336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="816" mass="102302" checksum="380F43525DB69FBC" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DAM6</accession>
    <name>A0A812DAM6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RUN domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_50618</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002998">
        <property type="protein sequence ID" value="CAE1294822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DAM6"/>
    <dbReference type="OrthoDB" id="10068328at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17683">
        <property type="entry name" value="RUN_RUNDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004012">
        <property type="entry name" value="Run_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037213">
        <property type="entry name" value="Run_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058732">
        <property type="entry name" value="RUNDC1_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047343">
        <property type="entry name" value="RUSC1_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15591">
        <property type="entry name" value="RUN AND SH3 DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15591:SF19">
        <property type="entry name" value="RUN DOMAIN-CONTAINING PROTEIN 1 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02759">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26030">
        <property type="entry name" value="RUNDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00593">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140741">
        <property type="entry name" value="RUN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50826">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RUN" evidence="2">
        <location>
            <begin position="380"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1294822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="570" mass="64230" checksum="62A32BD20D49F3C7" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DAS1</accession>
    <name>A0A812DAS1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_50325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002944">
        <property type="protein sequence ID" value="CAE1294283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DAS1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1294283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="227" mass="26225" checksum="965CE9E88A7CE4E0" modified="2021-09-29" version="1">MLQTSRFQRAFSFRCLAAGSFSLFFPSTLSLTRTSLQNTVLIHFYPFSLSFVLSFSLSLLFSLFISFSSLFSLTFSLSFLHVSPLSLFLSLSLFSLSLFLSPFLSPFSLFFTHIFILFLFLLSLSLTHLFFLFFFSFTDFSALFFLYSSFSFFFLFLLSLPFSSYHFLYLSSRFCLSFLFSPCLFSTLFFLSLFFLLSLSLSLCFLSPFSLALSFLPFLSLFPFSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DJG6</accession>
    <name>A0A812DJG6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_54750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003595">
        <property type="protein sequence ID" value="CAE1302074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DJG6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1302074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="376" mass="45118" checksum="E42338810877F649" modified="2021-09-29" version="1">MANSFFLSFFHSFIHSFFLSFIVCLFVSFSFHSFFLSSFFLTFFLSSFVCFIHSFILSFVHLFLFVSFFLLFIHAFFFLSFFQPFFHSLFVCLFLSFSFHSFFLSSFVCFIHSFTHSFILSSFFSLFVSFSHPFFFLFHSFFLFSFFLSFFLSFFLSFFHPLFVCFFFSFLSSFVCLFVSFFLSFIHSFFFLSFSFHPFIHSFIHSLHYFYSMHIFFFLTPFILNYWPTFRHCSQRICWHLTEPQQTPAIPILKTLHNLFLTIYLSICSYYLSIYLSIYYFCSYLSIYLSIYLSIYLSICVVEQDLLGNLCLVFCNFCLVYVHVSSFPETCSHFLVCPLVLPVYNFGYIFFAHVLLYYCLFKLLLSSGFLPSPFIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DJS3</accession>
    <name>A0A812DJS3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="15">GLIS2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SPHA_57307</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GLI C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003863">
        <property type="protein sequence ID" value="CAE1304759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DJS3"/>
    <dbReference type="OrthoDB" id="3214149at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000019">
        <property type="entry name" value="GLI family zinc finger 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000310">
        <property type="entry name" value="GLIS family zinc finger 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000357">
        <property type="entry name" value="GLIS family zinc finger 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000359">
        <property type="entry name" value="GLIS family zinc finger 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043359">
        <property type="entry name" value="GLI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056436">
        <property type="entry name" value="Znf-C2H2_ZIC1-5/GLI1-3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45718:SF8">
        <property type="entry name" value="GLIS FAMILY ZINC FINGER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45718">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR CUBITUS INTERRUPTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23561">
        <property type="entry name" value="zf-C2H2_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="37"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="70"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="98"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="128"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAE1304759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="283" mass="32475" checksum="8D127BDCA698447F" modified="2021-09-29" version="1">MYRCQWADCNQKFVFMDQLVGHVNEKHVCVGRSEVEYQCKWEGCPRDGKGFNARYKMLIHIRTHTNEKPHKCPLCGKCFSRLENLKIHNRSHTGEKPYSCPVPGCSKAYSNSSDRFKHVRTHQEKKPYVCKMPGCSKRYTDPSSLRKHVRTHGHYFRRENRHVGYHKPLSNVKPVRLQLHGLSKLQTLARLESSSVTPAESSWTGTSGHRSNDHRFDSLSSPSIFSVPMRHQANAVTNHKNKVTSPRTCNQIASTNLRYVNPYDTNPQEIPLDLSLTKVMGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DLE3</accession>
    <name>A0A812DLE3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_55297</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003667">
        <property type="protein sequence ID" value="CAE1302934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DLE3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1302934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="235" mass="28298" checksum="B5F3C772A02123B7" modified="2021-09-29" version="1">MHKSVYLSIYLSIYISIYLSIYLSIYLSILLSEELITAAIRDLSLLFSHWFFFSFRLFYLSFSPPSFLPSFLPSFLPSFLSFFLSFFLSFFFSFFLCPSITFFLFLSLSFFLSFIFFSFFFSFLSFFLSLSVHLLLSFFFSFFLSFSLSFFLSFFLSFFLSFFLSFFLSFFFLFFLSFFIHLIFFLSFFLSFFLSFFLSLFIYLFICSSINFFLAFFFFLSFLLSFSFFLSFTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DNR4</accession>
    <name>A0A812DNR4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">H1_5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SPHA_55160</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003651">
        <property type="protein sequence ID" value="CAE1302685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DNR4"/>
    <dbReference type="OrthoDB" id="1110759at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031492">
        <property type="term" value="F:nucleosomal DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030261">
        <property type="term" value="P:chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045910">
        <property type="term" value="P:negative regulation of DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00073">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000140">
        <property type="entry name" value="Histone H1.0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005819">
        <property type="entry name" value="H1/H5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005818">
        <property type="entry name" value="Histone_H1/H5_H15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11467:SF36">
        <property type="entry name" value="HISTONE 24-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11467">
        <property type="entry name" value="HISTONE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00538">
        <property type="entry name" value="Linker_histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00624">
        <property type="entry name" value="HISTONEH5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00526">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51504">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="H15" evidence="7">
        <location>
            <begin position="26"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="79"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="105"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="146"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAE1302685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="444" mass="50490" checksum="45053E458C8B311E" modified="2021-09-29" version="1">MADTEAAAAPAPAKTKKASKPKKPSSHPPYGQMIQEAITNLKEKGGSSRQAIQKYLVSHYKIAADNVSGTQLKLALKRGVTSGQLKQCKGTGASGSFKVGEKKTEKKPKAKSKKPAKKAAAKKPKSPKKTAKPKKVAAKKAKKPKFSSSSSSSSSSSSSSSSSSQQTLSLSLSLSLSLSLSLSLSLSMPYIRDITYRHFSRHYLFSTPDIIYFLPRHYIFSPQTLLIFPQTLLIPHPRHYIFHPPRHYLFPQALLISPPDITYFSPDSTYFSPPGITYFSPDITYFPRHYSFPPDSTYFFPHQVLLIFPPDITYFFPRHYPPQTVLIFPHQVLLIFPPDITYFPRHYSFPPQTVLIFPHQVLLIFPPRHYLFPPGFTHPRPDITYISPPDITYLFLPDITYIFSTKHYLFSTPDITYFPPGITHFHSRHNLFFPRHYLFIFPRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DRG3</accession>
    <name>A0A812DRG3_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heme-copper oxidase subunit III family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_60809</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004248">
        <property type="protein sequence ID" value="CAE1309014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DRG3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000298">
        <property type="entry name" value="Cyt_c_oxidase-like_su3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50253">
        <property type="entry name" value="COX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="314"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="437"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="464"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="521"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="548"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="Heme-copper oxidase subunit III family profile" evidence="2">
        <location>
            <begin position="43"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1309014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="566" mass="65359" checksum="2E2DC78690599DCE" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DTB6</accession>
    <name>A0A812DTB6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_60003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004155">
        <property type="protein sequence ID" value="CAE1308018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DTB6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="78"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1308018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="216" mass="24320" checksum="99ABE6E173FC4FFD" modified="2021-09-29" version="1">MCQKLGFCSYTRCISLFISLFFFSNISLLTSFLYLSIALRSTASHSHSPYSPFFTPPAFSPLTTFSMIALPSLFLLFLSSCHPFFVKVPLSSFLSLKIGKRYIIFFSAFFLLNPYISQSTIAFSLPIHLYLFLVESRISKKKKKALSLSWMNTFSADTGGRDDGDYTHDGSLQFVAKKAATVSLPEIYIYNDAQSIYLSIYLSVCLSIYFALSLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DUJ3</accession>
    <name>A0A812DUJ3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_58872</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004056">
        <property type="protein sequence ID" value="CAE1306678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DUJ3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
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        <location>
            <begin position="6"/>
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    </feature>
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        <location>
            <begin position="35"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1306678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="175" mass="21270" checksum="5A29245CE90821AD" modified="2021-09-29" version="1">MSSFHIFFIISFCFYLFLSPFIFLSLFLSSFLLSYISLFFSLPFFFHISFSFSFFFSISFCFLSPLVYLSVFFLPFFFRISFSFLSFPFFFRISFSFSFFYSISFCFSFFPSFVFISLFSPPFFFRISFCFSFFPSFVFISLFHSPFLFSYIFLFSLPFFFRISFSFSFFFSISF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DV66</accession>
    <name>A0A812DV66_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_59191</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
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                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="CAE1307083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000597762">
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    </dbReference>
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        </location>
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        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1307083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="197" mass="23777" checksum="12DAFAF405BA0CDA" modified="2021-09-29" version="1">MKHKIYNKNISIHLSIYLSIIYHHLSSFKFPPIPIYSYLFIYSFIYLFISIHSFIYLLNLLFIFIYIKLVSFIHLSIYHLFIHSFIYLSIYLSIHIYLSSIYLKSIYLIYPYLYIIIYLKIYLSIYSSIYIHLLKIYLSIYLIPSIHSYISYILFIYHLSINIHLSLSIYESIYIYLSIHSSIYLSIYSSIYSSSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DVJ4</accession>
    <name>A0A812DVJ4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_63177</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004531">
        <property type="protein sequence ID" value="CAE1311807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DVJ4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="334"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="373"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="407"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="437"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="473"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="508"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="536"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="564"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1311807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="597" mass="72454" checksum="8F1DA4AC302423C2" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DYV2</accession>
    <name>A0A812DYV2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SRGAP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SPHA_61124</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004296">
        <property type="protein sequence ID" value="CAE1309388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DYV2"/>
    <dbReference type="OrthoDB" id="5981864at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04383">
        <property type="entry name" value="RhoGAP_srGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000026">
        <property type="entry name" value="Rho GTPase activating protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000136">
        <property type="entry name" value="Rho GTPase activating protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051627">
        <property type="entry name" value="SLIT-ROBO_RhoGAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14166">
        <property type="entry name" value="SLIT-ROBO RHO GTPASE ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="Rho-GAP" evidence="6">
        <location>
            <begin position="171"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="396"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="137"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="456"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="595"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="457"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="497"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="517"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="631"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="689"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAE1309388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="775" mass="86910" checksum="3D13C875722DAE9D" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E103</accession>
    <name>A0A812E103_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cerebral cavernous malformations 2 harmonin-homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SPHA_64431</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Farmed</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCM2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004634">
        <property type="protein sequence ID" value="CAE1313244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E103"/>
    <dbReference type="OrthoDB" id="5828470at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032375">
        <property type="entry name" value="CCM2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026159">
        <property type="entry name" value="Malcavernin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21642:SF6">
        <property type="entry name" value="CEREBRAL CAVERNOUS MALFORMATIONS 2 HARMONIN-HOMOLOGY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21642">
        <property type="entry name" value="CEREBRAL CAVERNOUS MALFORMATIONS PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16545">
        <property type="entry name" value="CCM2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cerebral cavernous malformations 2 harmonin-homology" evidence="3">
        <location>
            <begin position="263"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="195"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="195"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAE1313244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="411" mass="46288" checksum="36E94A4180F67807" modified="2021-09-29" version="1">MEDKKREKKSPYRSTHDSDMYDKLDSRKGSKHLSLDYHVSTQTLLESYVEKKVRFAGVVPDVQIDDLTNRTDVLRIIDEGKRQGSIHHHTTDKEHGASFTLNVHNIKLMCQRELLLRISMHEIAAVCYIKDDSDNILAIKYGVPDKCNLAVLYVDNRIQAEEICALVDQCFQLVYTEAAIQFIDTKLTGAFTTSVTSSNTQSEPQDSNPINNPADPPLKLSYITTSDQNLTKNSSSSCTRTSPKRSNRTTSITTDSEIGLAGCFEVLQDYLKKLPKCLTVKELRQFAMLLKAWHNEPGTTTSEFCEKVFNLYGQERKHMLAGMGPFIPAEEYHVFEEFLNKNSVTLPANGHGTISSYRSYTPQRSNSVSDIGTTTHSMNGADSDEFDRMIDCFSNQIDLMESSVEVDSVMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E186</accession>
    <name>A0A812E186_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_64080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004613">
        <property type="protein sequence ID" value="CAE1312902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E186"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033002336" evidence="2">
        <location>
            <begin position="23"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1312902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="241" mass="27983" checksum="59B26B3C4AF24E96" modified="2021-09-29" version="1">MNRLKTALILPIPFLPASLLIASTKLGQKYKFARRAGHKNTESTNDGSCFLYNLLSQLFYTIPFETSSFSPFFSFTTLHPFSLYHSFNFSFSSPFNYFLITVSFYVSFPHHTYTSHFFSPSSLSLNIFHRRSELPFHPLLNIFLLFSLLFQPLSLIYYLTSDQLPSLFSSFQFLSSNYILPLTFSLILFYLQLLPFSQLLCTCLLPLSQLFLNIFSLRRIFGIKICSRLSKFYVIKSISKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E305</accession>
    <name>A0A812E305_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_65534</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004724">
        <property type="protein sequence ID" value="CAE1314574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E305"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1314574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="152" mass="18064" checksum="A4E6E4028505EB13" modified="2021-09-29" version="1">MSIQFHTFSLTSPFYFSLMFSPFLFSLTFPLYFFFSPNMSIQFHTSSLTSLFYFSLMFSPFSFSLTFPLYFFFLSNMSIQFHTFSLTSTFYFSLMFSPFFVLSNIPIIFFFLSLMCPSNFTFSLTSLFYFSLMFSSIFSFSLTFPLYFFLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E581</accession>
    <name>A0A812E581_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SLC23A1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SPHA_64639</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004648">
        <property type="protein sequence ID" value="CAE1313507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E581"/>
    <dbReference type="OrthoDB" id="6148241at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11119">
        <property type="entry name" value="XANTHINE-URACIL / VITAMIN C PERMEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAE1313507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="407" mass="44072" checksum="E4A25D1FEC23DA39" modified="2021-09-29" version="1">MLPIVVANSAFCMNGDSVGISELISTTFFISGLSTLLQTTFGCRLPIVQGASVSFIAPTITLFSLQKLQCPYTRDLSVNNTLPDVGSDGHREIWQLRLREIQGCLMVGSLIQIFIGFSGLMEVFLSFVGPLTIMPTITLIGLSLFEVATDYSAGQWYIALLTTALICIFSQYMKNIDVPCFLYKKDGGCSKIPIALFKMFPILFAILISWLLCHILTITDVFPKEKSKWGHAARTDLYRDVLDKSAWFRFPYPGQWGMPSVSTAGVFGMFTALFASIIESVGDYYACARISGAPPPPVHAISRGIGMEGITCFLAGVWGAASGNTSFSQNIVTSEMAITNPPPKSLCGLRASPTLLSAGPSSLDLLYENNLSLSFSLSFSLSLSLSLSLSLSLSLSLSLSGQDRNKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E7R6</accession>
    <name>A0A812E7R6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_65958</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004744">
        <property type="protein sequence ID" value="CAE1315002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E7R6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="295"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1315002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="314" mass="36800" checksum="5E6212F2909AA64F" modified="2021-09-29" version="1">MEVVMSYLNVTRGVLNLYFSYHLLYSVCLLVLFRGLFPHFSLCYISPLCPSLNPALFLSLSLYLPNPPFSFFSRSQWPGKLLQLAHDLEPLGAFASVETSGITRHGVSLSLSLSLLFCLHFFMSLLTLIFFLFFFSFSLLFHSSFLLAISIPSIPFFLSFLVRFSLLLFLSLFILLPYYFCFCLSLFFLFYVYCFSFSYFFLFLYSFPSLSLFILLSYSFPFLLSFYSSLFSCVSTSFFFVFFILSFLFYLVFFFFSFTLSFSSGFLSDLIFFFPSIFHFLSFFLSFFLSFFHCHFHILIMFTFSVFFILSKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E7X7</accession>
    <name>A0A812E7X7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_68112</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004943">
        <property type="protein sequence ID" value="CAE1317552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E7X7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="323"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="353"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="381"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="405"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="429"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="461"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="490"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="524"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="564"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1317552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="625" mass="74860" checksum="708071618C34978D" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E933</accession>
    <name>A0A812E933_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_70384</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005155">
        <property type="protein sequence ID" value="CAE1320128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E933"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="332"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1320128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="393" mass="45627" checksum="27FD2B290F72D187" modified="2021-09-29" version="1">MEISLSLSLSLSLSPYSLSSRSLSLFSLFSLSLCLSLTLSLSHTHARALSRYNSKKNPCGITGCKNIFFFTVITTIWFVNDFFFFFFFFFFFFFFFFVVVVVFLTFILYNLSIYLSIYLSIYLSISALYYYLSIYLSIYLSIYLCQPVHIYLSIYLSIYLNAVHCYLSIYLSIYLSIYLSIYLSKCSTLLSIYLSIYLSISACSYLSIYLSIYLSKCSILLSIYLSIYLSIYLSMSACSYLSIYLSIYLSIYLSTSACSLSIYLSIYLSIYLSKCSILLSIYLFIYLSIYDLFISIYLSIYLSVCLSISLSISVSSYLSIYLSIYLSQFVSIYLSFFISIYLSITVCFYLSIYLSIYLSIYLHESVHIVRKQLKVFFFVSLQCFLIKSNYSLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E9P1</accession>
    <name>A0A812E9P1_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">m7GpppN-mRNA hydrolase NUDT17</fullName>
            <ecNumber evidence="8">3.6.1.62</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Nucleoside diphosphate-linked moiety X motif 17</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SPHA_69696</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Farmed</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Acts as a decapping enzyme capable of hydrolyzing monomethylated capped RNAs (in vitro). Hydrolyzes monomethylated capped RNA after alpha and beta phosphates to form N(7)-methyl-GDP. Shows low activity towards unmethylated capped RNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = N(7)-methyl-GDP + a 5'-end phospho-ribonucleoside in mRNA + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:67484"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:17167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:63714"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="EC" id="3.6.1.62"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.62" evidence="8"/>
    <dbReference type="EMBL" id="CAHIKZ030005099">
        <property type="protein sequence ID" value="CAE1319308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E9P1"/>
    <dbReference type="OrthoDB" id="447842at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140933">
        <property type="term" value="F:5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035529">
        <property type="term" value="F:NADH pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019677">
        <property type="term" value="P:NAD+ catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006742">
        <property type="term" value="P:NADP+ catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04694">
        <property type="entry name" value="NUDIX_Nudt17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050241">
        <property type="entry name" value="NAD-cap_RNA_hydrolase_NudC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033716">
        <property type="entry name" value="Nudt17_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42904:SF1">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE-LINKED MOIETY X MOTIF 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42904">
        <property type="entry name" value="NUDIX HYDROLASE, NUDC SUBFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="13">
        <location>
            <begin position="93"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00093205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00093415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00093621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00093663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAE1319308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="305" mass="34155" checksum="E6970EAA50A1145D" modified="2021-09-29" version="1">MSAVQTVPKRILVYLKHASRDKNPVLAKFTQCLVDYFDQSELTTLVHGYLQDNCFVLTNEISPHTMPLILKHPSFCPIHCLSPNIDLPNEIIHRGIDVGVAVILESMDNKILLTRRAKHLRTFPGIWVPPGGHVEGQETLTEAGLREFKEETGLEVSPKQCIGEKLNLMAFWESVYPAKLNHGDPKRHHLVTYLHGKLKELNSEAASAQLQIEPNEVDACAWLDRTVISAIVASDEEQSVQIENPLPDLPSYFRAHILSEEQKMVECSLPLAPLLRVASGTCDTGLERVSSGTKFALEQWLKLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EB71</accession>
    <name>A0A812EB71_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_68030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004932">
        <property type="protein sequence ID" value="CAE1317456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EB71"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="305"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="340"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="369"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="405"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="432"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="462"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="490"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="526"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1317456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="558" mass="67473" checksum="A0769C8910454CB0" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ECL7</accession>
    <name>A0A812ECL7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_71952</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005273">
        <property type="protein sequence ID" value="CAE1321900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ECL7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="336"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="361"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="417"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="460"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="494"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="520"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="547"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="593"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="623"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="654"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1321900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="690" mass="80200" checksum="0B13A43C1AD0FB02" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EDE1</accession>
    <name>A0A812EDE1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_70528</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005166">
        <property type="protein sequence ID" value="CAE1320272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EDE1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1320272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="223" mass="26965" checksum="9A3A3579A66ED4FC" modified="2021-09-29" version="1">MLSGHNSHSFSFFFFPLPTHHINLEAGKCFRFFLLPPLEYFNCLLRHVIFTRRGGSSTRRRCVQQHTTQKIQVFIMKLFHFLSFFLSFFLSFFRSRFSSIYLSIYLSIYLSIYLSIYLRLFHFLLSFFFVVALHISFYVGLFLFLSFFLSFFCSRFSSIYLSIYLSIYLSIYLSILDYFIFFLFSFFYYFSFFLSLSIYLSIYLSIYLSIYLSIYLTQVQKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EH45</accession>
    <name>A0A812EH45_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">THAP4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_73612</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>peroxynitrite = nitrate</text>
            <dbReference type="Rhea" id="RHEA:63116"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:25941"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:63117"/>
        </physiologicalReaction>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005382">
        <property type="protein sequence ID" value="CAE1323767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EH45"/>
    <dbReference type="OrthoDB" id="58529at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07828">
        <property type="entry name" value="lipocalin_heme-bd-THAP4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045165">
        <property type="entry name" value="Nitrobindin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014878">
        <property type="entry name" value="THAP4-like_heme-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15854:SF4">
        <property type="entry name" value="PEROXYNITRITE ISOMERASE THAP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15854">
        <property type="entry name" value="THAP4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08768">
        <property type="entry name" value="THAP4_heme-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THAP4-like heme-binding" evidence="2">
        <location>
            <begin position="15"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00036993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1323767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="167" mass="19127" checksum="325D5A54E5D36B37" modified="2021-09-29" version="1">MDNEPMTSLPLHDAIKPLEWLLGSWYSTNGEGGFPTISTFKYGEKLQFHHVGQPNIQFSAYAWHLESKKPLHRELGFIRIKPGTNEVAWLGAQNLGLVEIEEGMVTGKTMHLESHTIGRLTFAREPITKKIVRKFSRVGDTLEQTVYMRTSNTEEMTKHLQISYQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EJK0</accession>
    <name>A0A812EJK0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SPHA_74822</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Stress granule</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MCRIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005440">
        <property type="protein sequence ID" value="CAE1325145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EJK0"/>
    <dbReference type="OrthoDB" id="9983138at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029428">
        <property type="entry name" value="MCRIP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14799">
        <property type="entry name" value="FAM195"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="151"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="209"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="259"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="227"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAE1325145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="326" mass="37717" checksum="2AD00B30EEDDA835" modified="2021-09-29" version="1">MRFVDSPSTVFYWSKFSVRRRKNKYNTHLEADSILYSYLSIYLSIYLSIYLSIYLSIYLSIYLSISATIIFLFEEEEKNVSNLTSGFRFSISFSLLPHFTISLSPLLPPLLHASLFSSCLPLRQLAVRKRLNQSPKLTEAMYTNASRRNKNIITNSRGPHNSLDHIEGRGDSNTTTKRTTVGHHTTAMRYTARQFHSAAALHEKECPQTLNSPKSVFNGKRPVSSVHRPNSYSSDPQSPQHEEIVKYLTDAWNRVTHDMESRHPRDNKAWNRVTHDVDNRHPRGNKGSTPTWYKEKSPNPQVENFKPFDLEKWHGQRTIEKIRGTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EK48</accession>
    <name>A0A812EK48_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_77012</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005501">
        <property type="protein sequence ID" value="CAE1327537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EK48"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1327537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="151" mass="17457" checksum="6935963E1ADF49E7" modified="2021-09-29" version="1">MAVHYTTAHPQYRFLILVAVHYTTAHPQYRFLILVAVHYTTRTSQYRFLPGDPSTVPILWLFIIPPVRPQYRFPNSEWLFIIPPVWSAVPTLYQAVPQYNSGTCLFIPPVRPQYRFLILVAVHYTTRTSTVPISNSGGCSLYHPHVHSTDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EN09</accession>
    <name>A0A812EN09_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_75576</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005464">
        <property type="protein sequence ID" value="CAE1325984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EN09"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1325984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="242" mass="28280" checksum="83FF38B45F554376" modified="2021-09-29" version="1">MSSIDEKPLSWFIRLIHDTCIHLNKSMLLLCLFHFNSTMSSIDEKPLSWFIRLIHDTCIHLNKSMLLLCLFHSNSTMSSIDEKPLSWFIRLIHDTCIHLNKSMLLLCLFHFNSTMSSIDEKPLSWFIRLIHDTCIHLNKSMLLLCLFHFNSTMSSIDEKPLSWFIRLIHDTCIHLNKSMLLLCLFHSNSTMSSIDEKPLSWFIRLIHDTCIHLNKSMLLLCLFHSNSTMSSIDEKPFHGSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ENK0</accession>
    <name>A0A812ENK0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_75915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005477">
        <property type="protein sequence ID" value="CAE1326329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ENK0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
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            <begin position="44"/>
            <end position="74"/>
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            <begin position="80"/>
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            <begin position="107"/>
            <end position="128"/>
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            <begin position="148"/>
            <end position="174"/>
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        <location>
            <begin position="186"/>
            <end position="209"/>
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            <end position="253"/>
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            <begin position="265"/>
            <end position="289"/>
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        <location>
            <begin position="409"/>
            <end position="434"/>
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        <location>
            <begin position="441"/>
            <end position="464"/>
        </location>
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        <location>
            <begin position="470"/>
            <end position="490"/>
        </location>
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        <location>
            <begin position="497"/>
            <end position="519"/>
        </location>
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        <location>
            <begin position="525"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="554"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1326329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="583" mass="71549" checksum="C8557D79F8FEA9C2" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ENS9</accession>
    <name>A0A812ENS9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_79421</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005566">
        <property type="protein sequence ID" value="CAE1330047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ENS9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="305"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="343"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1330047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="403" mass="48546" checksum="60AA05F09B02D37E" modified="2021-09-29" version="1">MFFQIYLSVFLLFFSFFLSFFHSFFFFYTSFGYFSFPFSFFLFSSFSLLISFFPFSHFLHDFFVVLFLQLFPFPVLSFLFHVVIFFQLLLSPSFFFLLFFKLFRFHFLTFFFLSFFPFYSSFSYFSLPYFLSFFLSFFSTLHSAISLFFLSFFLFYSSFSYFSLPYFLSFFLSFLLFFQLFLFTLLSFFLSFFSTLLSAISLYLTFFLSFFLSFLLFFQLFLFTLLSFFLSFYSSFSYFSFLSFFLSFLLFFQLFLFNLLSFFFLSFLSTLHSTISLFSFFLYFFSTLLLAISLSLSFFSTLHSAISLFLSFFLSFFSTLLLAISLSFSFFSTLHSAISFPFLSFFLSFLLFFHLFLLPFLSFFLFLLFFHSFLSTSLIFSFLSVMSLSSVVARWNEKTNKNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EPY1</accession>
    <name>A0A812EPY1_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">rhomboid protease</fullName>
            <ecNumber evidence="4">3.4.21.105</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SPHA_78753</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Farmed</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains.</text>
            <dbReference type="EC" id="3.4.21.105"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase S54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.105" evidence="4"/>
    <dbReference type="EMBL" id="CAHIKZ030005551">
        <property type="protein sequence ID" value="CAE1329264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EPY1"/>
    <dbReference type="OrthoDB" id="10260614at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050925">
        <property type="entry name" value="Rhomboid_protease_S54"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43731:SF14">
        <property type="entry name" value="PRESENILIN-ASSOCIATED RHOMBOID-LIKE PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43731">
        <property type="entry name" value="RHOMBOID PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="142"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="303"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="333"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="362"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="394"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="419"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="457"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="490"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="526"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="554"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="589"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="632"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAE1329264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="693" mass="83579" checksum="40E6CB788834C3F6" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ER75</accession>
    <name>A0A812ER75_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_80562</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005602">
        <property type="protein sequence ID" value="CAE1331370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ER75"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="337"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="386"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="444"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="470"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="496"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="524"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="553"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1331370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="577" mass="68584" checksum="79B1A81ACBEF5837" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EW70</accession>
    <name>A0A812EW70_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_78850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005552">
        <property type="protein sequence ID" value="CAE1329322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EW70"/>
    <dbReference type="OrthoDB" id="15627at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1329322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="766" mass="87097" checksum="4CCA84E4DF2F08BD" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EZ20</accession>
    <name>A0A812EZ20_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RPB1</fullName>
            <ecNumber evidence="2">2.7.7.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_79754</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="2"/>
    <dbReference type="EMBL" id="CAHIKZ030005576">
        <property type="protein sequence ID" value="CAE1330450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EZ20"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="301"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="340"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="364"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="399"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1330450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="418" mass="48837" checksum="4F9A3A4D48363095" modified="2021-09-29" version="1">MHILSLLFLTFLSFVPTSSSVLLFVFFSFLISLSISLPLSLNNPFSFCSLLPYPFNLCILTLSHSISLPFHSLYPYHFTLLPHPFTLYILTILLSFLTFSLSISLPFYSPSSPFHSLYPYHFTLLPHLFTLYILTILLSFLTLSLSISLPFYSPSSPFHSLYPYHFTLLPHPFTLYILTILLSFLTFSLSISLPFYSPSSPFHTLYPYPFTFYILTLSLSTSLHFHSSSLPFQPLLLSPFTLYFLTLSFFTPFPMESFNFSLSTPLSFHSPYPHHFTLYILILSLSISSPFHSLYPHPFTLYILTLSLSISLPFYSLLPHHFTLYFLTLSLSTFLPFHSLYPYPFIFYILSNFTLYYFPHGLLLLYSFTLYSFILSLSNSFLLLFKFFSSTFLSFHHKIFFLLSFYHFLFLFYVFFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812F0V8</accession>
    <name>A0A812F0V8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_80724</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005609">
        <property type="protein sequence ID" value="CAE1331519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812F0V8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1331519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="169" mass="19888" checksum="07237FAB0A2A36E4" modified="2021-09-29" version="1">MVALFTYIITTASIYLSKSVLYLSIYLSIYLSVCLSIYLRLLISIYLSIYLSYFAHIYQSIYLSIYLRLLISIYLSILDCSYLSIYLSYLLISIYLSIYLSYFAHIYLSIYLSVYLSIYLSLLISIYLSLLISIYLRLFISIYLSIYLSIYLSIYLILLISIYISIYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AK27</accession>
    <name>A0A812AK27_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_1780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000051">
        <property type="protein sequence ID" value="CAE1146255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AK27"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="320"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="357"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="400"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="428"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="466"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1146255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="505" mass="60142" checksum="B7518F86521AE5AB" modified="2021-09-29" version="1">MFSFLSFFFLSFFFLSVFFLSFYFVHTIFLIFNSFIFIFLTDLYLYFIISFSFPHLQLIFSFIFFIYFSFIHSSSIFYLFLSFFFLLNLSQYVYLFVIFAFVQFFLFLFLFLSFLFPFCFPHFISPSFSNRRPHRCLRCSFFFSFHLHIYVSRISAILTPFILHIFHTTRCPSNSFPSRFVLFFFIFFTADHRSRNNNDTNDNFIYFLFSHSNYNFFLSFSFSLSRSIYLSIYLSIYLSIYLSIYLSHSVSDPSIYLIHLSIPFCSLSHSVSNLSIYLSIPVCFLSHCVSNLSIYLSIYLSIYLSIYLSIPVCSLPHSNLSIYLSIYLSIYLSIYLSKGPRSKCQSAFLSPTSPSHILSFSYLSIYLSIYLSIYLSIYLSIYLSIYHPLFLNTKLYMPDFVFYLSLIFFLSLISFLFSFSTLAFPSFLILFFLSFFLYFFLSFFLSFFLSFFLHPRLFFPSRSYDFFLSFFLSFFLSFFLSFFLSHGLMSFSLCLSICSPFVHSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AKM7</accession>
    <name>A0A812AKM7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_764</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000020">
        <property type="protein sequence ID" value="CAE1141092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AKM7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1141092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="269" mass="31649" checksum="D9BAA33D51E393BC" modified="2021-09-29" version="1">MSLIYLSIYLSIYLSIYLSIYLSIYLSPFHIYLSQYAHISLSTSIMCIWYMHISLFTSLTLSISIYLSIYLSIYLSIYLSIYLSIYLCLFISLSKNYLSIYLSKSSLLYEINMTFSWICPSIYKKINPNSFLSLRFTYTYSWPFISYLSIYLSQSIHIYLSSLLLLLFTYLSSLISTFIILFIPLSIYLSISSAHYLFIYLSIFLSISVHSYLSMYLSSLFLLIFTYLSISVHVYLYYSVHPTIYLSIYLSIYLSIYLSMSLLIYQDNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ALH1</accession>
    <name>A0A812ALH1_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytoskeleton-associated protein 2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SPHA_311</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CKAP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000004">
        <property type="protein sequence ID" value="CAE1139034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ALH1"/>
    <dbReference type="OrthoDB" id="6288182at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007026">
        <property type="term" value="P:negative regulation of microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029197">
        <property type="entry name" value="CKAP2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026165">
        <property type="entry name" value="CKAP2_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16076">
        <property type="entry name" value="CYTOSKELETON ASSOCIATED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16076:SF8">
        <property type="entry name" value="CYTOSKELETON-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15297">
        <property type="entry name" value="CKAP2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytoskeleton-associated protein 2 C-terminal" evidence="6">
        <location>
            <begin position="193"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF15297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAE1139034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="432" mass="49854" checksum="AD797BC296A9B013" modified="2021-09-29" version="1">MDVENKRKEYIQKWENYKSQKLKEKAENIKKAENMKKTKHTSLSSKVTRYSGVTKLRRQTLASFENKTHMDTRSRLSLAPYLHKPYSHNQSKCLDEKREKMNEWLRKRGKAPVTNRHSLCFCKQAPDHDGPRCKRTLTKEEIMMQKKKLDDEKHKVAECDQENLENCEVKKDEHLFPKMEIPKETLQELNESEQMDPVIQECSILLDAGCPSSNILNWLKEIQDRLPAVMNSAEFWLLKARVHAIDKDIDSLLEVFSNAMKHRATPINTIADSMPQMIKDVMSSSNETKKDEICTVEEMPVSENELVDLDEMSDDGSLYSPSQSPAFMDSIFDYDVDDIEYKTPVPPVTPGMMRLPESSSIKYSVKKTTPFKKRGNNHDESAVIVTPVRRSNRKSMGRKSLVENVISSLDELSFSDKQNLLLKSNVALENFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812APV2</accession>
    <name>A0A812APV2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_4477</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000141">
        <property type="protein sequence ID" value="CAE1155381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812APV2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="307"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="362"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="392"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="422"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="449"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="475"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="507"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="575"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1155381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="594" mass="70497" checksum="F7716019991F3ED9" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ARJ3</accession>
    <name>A0A812ARJ3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_3128</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000091">
        <property type="protein sequence ID" value="CAE1151382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ARJ3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1151382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="155" mass="17066" checksum="F1B8DF43D6A203D9" modified="2021-09-29" version="1">MCAKIFNFLSLLIHLSLHSSIVFLLLSSTSFALLLFPTSLSLSLSFCRPLLVFSLSLSLSLSLSLSHVFTLQSGIDRFCLSLLSMIPFPFSLFLSLLLFASTAAAASMPSSPLALLKLWKNAKSLRQMCKFQCTQHLNNGCLHSEIHSLSILHDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ARP3</accession>
    <name>A0A812ARP3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_4270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000133">
        <property type="protein sequence ID" value="CAE1154624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ARP3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1154624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="201" mass="23818" checksum="A6796410851ACD17" modified="2021-09-29" version="1">MRNSFSFAINGFSRHFFFPLRFPNYLHDSSSFYFSLLSYSLSLSLSLSLSLSIYLSIYLSIYLSISVHYISIYVCSYLSIYARSYFLSLHLSMAVHIYLSIYLSIYLSIYLSIYPRHFISIYLSIYLSIYLSIYVYSYLSIDVRSYLSIYLWLFISIYLSIYLSIYLSLVKPSSSQRLTDTHTHIYLSIYLSIYLSIYLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AUY0</accession>
    <name>A0A812AUY0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_6229</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000204">
        <property type="protein sequence ID" value="CAE1160049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AUY0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1160049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="234" mass="27044" checksum="258E64435431F1C1" modified="2021-09-29" version="1">MFLINLFFFFFFLSPPLFLFYIPGSFSFTMHTSLSLSLSLSLSLYRFLYFLSSFFLFSFPLHPVGPFRPDVPSFPKAIACKLSNVTFHHRISQQITTLILADRYVDCDLKLSLSLSLSLSLSLSLFPTFSISYIQEHTFDLSIYLSIYLSIYRYSAFRISIQISASNNPILPHPIYLSIYLSIYLSIYLLIYLSACICLLCLSIYLSIYLSTNISICLYIFIMSVYLSIYLSIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AW66</accession>
    <name>A0A812AW66_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_6942</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
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            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000224">
        <property type="protein sequence ID" value="CAE1161552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="9635126at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN (PUTATIVE)-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="PROTEIN (PUTATIVE)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
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            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
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            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="274"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1161552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="293" mass="34725" checksum="1C217C3E973C5843" modified="2021-09-29" version="1">MKHFYLSFFLSFFLSFFLSFLFALKPSSSEHIYLSIYLSQNVRIYLSIYLSIYHKMFVSIYLSIYHKMFVSIYLSIYLSIYLSIYHKLFVYIYQSLHTSIYLSIYLSITNCSYLSIYLSITNCSCLSITNCSYLSIYHKLFVSIYHRLETSIYLSIYLSIYLSQTVRIYLSPSGDIYLSIYLSIYLSQTVRMYLSPSGDIYLSIYLSQTVRIYLSPSGDIYLSIYLSIYLSQTVRIYLSPSGDIYLSIYLSIYLSIYLSIYHKLFVSIYHRLETSIYLSMFLYFILVYLSMNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AWB8</accession>
    <name>A0A812AWB8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_6265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000206">
        <property type="protein sequence ID" value="CAE1160161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AWB8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="101"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="157"/>
            <end position="180"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="186"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="225"/>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="266"/>
            <end position="287"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="328"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="366"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1160161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="385" mass="47267" checksum="31B0CDCD2E672053" modified="2021-09-29" version="1">MRVLSPILSFFLSFLLSFFPSFFLSFLLSFFLSFLLSFLLSFFLSFLLSFFPSFFLSFLLSFFLSFFLSFFHLFYSFFLSFFLSFFLSFFGSFICFILSFFLSFFLSFFHLFYSFFFLSFFLSFFPSFFLSFFLSFFLSFFLFFFLSYFLSFVPSFVLFFLSFFLSFFLSFFLSFLHLFYSFFLSFFLTFFLSFFRSFICFILSFFFFLSFFLSHFFSLKLVSNFYLFFLSFLNSLNLFIISLDVISFFLSFFLSFYSLHHSFIHYFNNSFFLSTRYTIVSFIHSFFLSSRHTILSFIILFFLSFFLSFFLSFFLSFFLSFYSSIRSFIHSFFLFSFFTFAYIVIYKYFFYTRNDYFLTQHIYKKYLSIYLSIYLSIYLSISVWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AWH6</accession>
    <name>A0A812AWH6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_5093</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000169">
        <property type="protein sequence ID" value="CAE1157193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AWH6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
    </feature>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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        </location>
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        <location>
            <begin position="622"/>
            <end position="644"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="650"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="673"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="698"/>
            <end position="719"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAE1157193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="736" mass="87778" checksum="6931B5DABCCAF78B" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AWV5</accession>
    <name>A0A812AWV5_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heme-copper oxidase subunit III family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_7298</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000236">
        <property type="protein sequence ID" value="CAE1162433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AWV5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000298">
        <property type="entry name" value="Cyt_c_oxidase-like_su3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50253">
        <property type="entry name" value="COX3"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="34"/>
            <end position="51"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="343"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="404"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="431"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="465"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Heme-copper oxidase subunit III family profile" evidence="2">
        <location>
            <begin position="218"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1162433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="504" mass="60411" checksum="81512091C83CC6A3" modified="2021-09-29" version="1">MSPLSLSLSLSLSLSLNSASLFFFLSFSFFYPDYFGFFLSFFLFFLILLSFDHSFFHSFILSFFLILLSLDHLPSFLFFFLLFSLFWFYFFLSFFLSFFLLILLFSFDHSFFLILLSLDHFSFFLSFFLSFFFLSLGHLFSFFLFYFLSFFFCFLPYHSFCLFSSSLSILSILRLSLSFSLSLIRHLSLDHSFFLSSFFLFLSLFLSYQFFSCLSFFLSVLLSLLLFSYYSLFLSFFLCLFVCLFVCLFLSFFLSFFLSLFGCFSFFLSFCFRFFLRFTSSSPWYSFFLSFFLSFFPFSFLPLLTFVLSFFLSFFLSFFLSFLSFLILCLFQIPPPFSFLFFPLYTPSFFLSFFLSFFLSFFLSFFLNTVPVSNSSSFLVVSLAYSIFFYIFHRIIKLSLFSPLHTFFLSFFLSFFLSFFLSFSLSARLSVLNFSSFLSFSLTFPYVLFFSLYYSFASFHSFHSILFFIYLFIYFFFLSFFLSFFLSFFLCLFIYFHYISISSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AY18</accession>
    <name>A0A812AY18_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_7216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000233">
        <property type="protein sequence ID" value="CAE1162266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AY18"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1162266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="176" mass="21685" checksum="31532F5A6F587B98" modified="2021-09-29" version="1">MHFFFPSFYPPTFHFLFYFFYLPSFLNYLAFYFSLLLFLVFIIPFLDPFFYFPLSCPFPLFSPFFLHSLSIILSFLHSLSILSFFFFLSLFFPFSSLSLFFPFSSFFLYSFLFLFFPFSFSILSFFYSFLFLSLFFPFSILSFFFLYSFLFLSIFFPFSFYILSFFFHFSFYFLFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AZK9</accession>
    <name>A0A812AZK9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_7283</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000236">
        <property type="protein sequence ID" value="CAE1162450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AZK9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
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            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="438"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="492"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1162450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="630" mass="72482" checksum="6D17AA5B8E68F59A" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B3P0</accession>
    <name>A0A812B3P0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_9645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000309">
        <property type="protein sequence ID" value="CAE1167863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B3P0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1167863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="165" mass="18106" checksum="4E251EF104D718AC" modified="2021-09-29" version="1">MSAMGISPTAVARKKKKVRLYVLLFFFYLSLSLSLTHTPPLHFLLFNLFFFFSLTSDIIVLFCSKISLLFNDCFCPTFPSLSFPSLSLSLIPLSLSHSLSLSLSLPLSLSLIPLSLSLIPLSLSLIPLSLSLIPLSLSFPLSLSHSPSLSHSPSDITVLFISLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B6D8</accession>
    <name>A0A812B6D8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_11770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000391">
        <property type="protein sequence ID" value="CAE1171792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B6D8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1171792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="150" mass="17173" checksum="1CB12244832E0AB8" modified="2021-09-29" version="1">MLYLLAGQPSTQDNNKNKNSSGRNGMNINSFWVRPGRWKFVGRHDNLSITQHIHIYLSIYLSIYLSIYLSIYLYVSCPNDTKSMSCRTDSQVDIAEDHIGERSVRGMSHFYKKSGSYCCQVSLAGDIIRDAAAKEAKFINKFYRPTGRRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B7V0</accession>
    <name>A0A812B7V0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_11972</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000401">
        <property type="protein sequence ID" value="CAE1172275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B7V0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1172275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="283" mass="32585" checksum="0E3A45F7FC20E745" modified="2021-09-29" version="1">MPIPLLCVSVVSLCKPNANSTSLFLLFTYANRMPIPRLCVSVIYLCKPNANSMSLSFYYFLMQTECQFHVIMFLLSTYANRMPIPRLCVSVISLCKPYANSTCLCFWCLLMQTECQFHVFSFLLFPYANRMPIPRHCVCVISLCKPNANFTSLCFWCLLMQTECQFHVFVFLSFTYANRMPIPHLCVSVIYLCKPNANSMSLCFCYFLMQNEFQVHVFVFLVSTYANRMPIPRLCFCCLLMQIECQFHVFESLLFPDANQMPIPRLSVCAISSCKPNANSTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BD77</accession>
    <name>A0A812BD77_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ADCK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_14498</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000495">
        <property type="protein sequence ID" value="CAE1177145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BD77"/>
    <dbReference type="OrthoDB" id="427480at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13969">
        <property type="entry name" value="ADCK1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045307">
        <property type="entry name" value="ADCK1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051130">
        <property type="entry name" value="Mito_struct-func_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173:SF19">
        <property type="entry name" value="AARF DOMAIN-CONTAINING PROTEIN KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173">
        <property type="entry name" value="ABC1 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="2">
        <location>
            <begin position="152"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1177145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="567" mass="65145" checksum="214FAAD67C057F30" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BE47</accession>
    <name>A0A812BE47_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AIP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SPHA_15762</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000551">
        <property type="protein sequence ID" value="CAE1225617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BE47"/>
    <dbReference type="OrthoDB" id="5829758at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000052">
        <property type="entry name" value="Aryl-hydrocarbon-interacting protein-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039663">
        <property type="entry name" value="AIP/AIPL1/TTC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056277">
        <property type="entry name" value="PPIase_AIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11242">
        <property type="entry name" value="ARYL HYDROCARBON RECEPTOR INTERACTING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11242:SF0">
        <property type="entry name" value="TPR_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23322">
        <property type="entry name" value="PPIase_AIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="AIP/AIPL N-terminal FKBP-type PPIase" evidence="5">
        <location>
            <begin position="89"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAE1225617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="300" mass="34608" checksum="8EF8118B3C7CFDD7" modified="2021-09-29" version="1">MAEIFKDLREQGIQKKIIYPGQGEIPSYGDGVGWKLTFQYHTRKCDETVIDDSKKPGNQSMELLLGKKFTLRNIARSKDHGHSHTAPQKSHCCGMMSMTKQGLGYPDLDALLTNPEPLIFTLELIKIESPGDYKREAWELNETEKLEAIQVLREEGNNLYREQNFDEATDRYSEALGMLEQLMLIEKPGDEGWQKLNKMQIPLLLNFCQCKLLSNEYYTVIEHCNTVLKHDPDNVKALFRRGKAHIGAWNPEDARNDLERVIELDSSATKDARKQLKILEELKKQKDLEDRERLRGKLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BG98</accession>
    <name>A0A812BG98_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_15554</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000542">
        <property type="protein sequence ID" value="CAE1224914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BG98"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1224914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="209" mass="23644" checksum="D9536A7803D55541" modified="2021-09-29" version="1">MISLSQMISKHLAFFDFLSCETSTHDFSFLSLSLILSLSLSLSLSLSLSPFLYLFPSIFLSLSLPLVENSHSLSFYLSLSHTLSFIDYLSHILSLTLFLSVSFFFPLSFFIFLCLSLPFLLPLTFSISLFLTEIQLFDDFILDSYTNEVGQISLWAETTLSFSFSFSLSFSLSLSLFLFLSHPLSFTFSLSLFLFFLLPTLSLSLLTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BH29</accession>
    <name>A0A812BH29_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_16571</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000585">
        <property type="protein sequence ID" value="CAE1227835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BH29"/>
    <dbReference type="OrthoDB" id="10676651at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1227835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="251" mass="27563" checksum="65247740147C2DCC" modified="2021-09-29" version="1">MYPFKSLFFFHPCLTQPCLTHPCLTQPCLTQPCSTSAVSDAPVSDAAVSDATVSDAAVSDAPVSDSAMSDSAVSDAPVSDAPVRLNLPSFSSSTPLFLLLSPPHPPNHLRGLLLLSSSFLIFLLLSLSFTSSSNFIFLIIRFFSSSPFSSNSFFYLLLFYFFFYSILPPFSPSYFLLLLLALLSLLFPIVRLFSSVQSTARFRENENSFTDTSIHILLPFSLPTPYLSLSPITLSFSLSHHPIFLSLSLSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BIR3</accession>
    <name>A0A812BIR3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_18109</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000651">
        <property type="protein sequence ID" value="CAE1231468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BIR3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
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        <location>
            <begin position="187"/>
            <end position="211"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="223"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="279"/>
            <end position="305"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="366"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1231468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="387" mass="45709" checksum="5CF1142777F82B7F" modified="2021-09-29" version="1">MSKYIFLSYSRLQTGNGSIIFPYFFSSFSPPPTFPSILLIYFFHSPIPFANLFPPIKNFLPISIQLSFIFLFSPLPIYTLVDTLSSFKLFTSPRDSSSFILSFYFIQLTHFLLFLSSSTYSYCILYYPSLSILFLFLFISILYLILYPPSASSYLFYTRFSFLFSLFLTTSLSFFLSFILFNPFLFFIFFFIPSLSSPYPFLFLILIHSLHVMNSSHPPMGHFFIFFILLPTLFLLLLYILFSIYLLISSLLNYIHMHCHLHQQPPATSLFSPVMKFTIFFFFHFLTFFSFFLFNFFASLLWSFLTLNSFHRPHYLSANEKMTLSCYFFFPCTFPPFNCATGLQSYITQAWLHTWLDNFKNFSHVFWSPILPLFFFVSLSFPFCPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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    <name>A0A812BJC4_ACAPH</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">SPHA_17096</name>
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    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
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            <taxon>Coleoidea</taxon>
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            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000607">
        <property type="protein sequence ID" value="CAE1229081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BJC4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23304:SF189">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23304">
        <property type="entry name" value="SPOT2-RELATED"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
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    </feature>
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        </location>
    </feature>
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            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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        <location>
            <begin position="938"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1229081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="961" mass="116646" checksum="4CC76271510E38F9" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BJN9</accession>
    <name>A0A812BJN9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">SPHA_19963</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">Farmed</strain>
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    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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            <begin position="665"/>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAE1235893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BJU5</accession>
    <name>A0A812BJU5_ACAPH</name>
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        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">SPHA_18005</name>
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    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
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        <lineage>
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                <person name="Bekaert M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">Farmed</strain>
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    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
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            <begin position="9"/>
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            <begin position="38"/>
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        <location>
            <begin position="84"/>
            <end position="106"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1231048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="172" mass="19859" checksum="4D35BA7E1C0BDAC0" modified="2021-09-29" version="1">MEEEKAAKLAVFCVINNIWIYLSIYLSIYLSIYLSQPLIYLPISVCNLSIYLSIYLSIYLSIYLSNDELKALNCNSPSTQNNPYFVLGSPVHFPFFSFFFFFYSLLTHSSTVCQPVCDSFLLSFTVINGNNTCGFCEKPTDAHVRPDFRMQELEFSHEDLSIYLSIYLSIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BK34</accession>
    <name>A0A812BK34_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="15">PCDHD2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SPHA_18147</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000654">
        <property type="protein sequence ID" value="CAE1231549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BK34"/>
    <dbReference type="OrthoDB" id="6252479at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000004">
        <property type="entry name" value="Protocadherin 1 gamma 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050174">
        <property type="entry name" value="Protocadherin/Cadherin-CA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028:SF146">
        <property type="entry name" value="CADHERIN 96CB, ISOFORM D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028">
        <property type="entry name" value="CADHERIN-87A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 11" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="192"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="31"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="92"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="267"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="269"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="281"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="361"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAE1231549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="415" mass="46430" checksum="4A46A176725689BB" modified="2021-09-29" version="1">MEEGKNPGTYIGDVAADSHLLDQVPYQEHHEFQDIYEFKVLVEDNGTPSLNNTADVVIEVTDENDNSPYFTFPSVNPYSLDVLYYPHHTKNITILKATDKDSLENAFLSYEIVRGNDNKIFAVNRYSGLLSFNREANQHDAGAHDLQFVVKDSGIPTLSASTNLSLVLTVSNLTSEMFNATHIQLSEKIHQYLLIVIVLVAVTLAVPITASLSICCIRCNERRKAPRNGRLKISKKKLDQQRHLIVHPHLATAWSEVAIVRSAEANGVRPAQPARQKQAQSSDENLNQTRKSSTLTMKRQKASDIIYQEIDTEDTNEQTQFIIPDVQRELKSAKTDSEDGWSDAELKAAQQLKDLSSSDYIEPHSSDKDQISSRCEASSQEPLLFSVDSGFNTPYGIVPFPEAAAVYRYLENVSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BP10</accession>
    <name>A0A812BP10_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">IRS2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SPHA_24144</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000897">
        <property type="protein sequence ID" value="CAE1244076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BP10"/>
    <dbReference type="OrthoDB" id="946068at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005158">
        <property type="term" value="F:insulin receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043548">
        <property type="term" value="F:phosphatidylinositol 3-kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008286">
        <property type="term" value="P:insulin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01204">
        <property type="entry name" value="PTB_IRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039011">
        <property type="entry name" value="IRS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002404">
        <property type="entry name" value="IRS_PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10614">
        <property type="entry name" value="INSULIN RECEPTOR SUBSTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10614:SF13">
        <property type="entry name" value="INSULIN RECEPTOR SUBSTRATE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02174">
        <property type="entry name" value="IRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00628">
        <property type="entry name" value="INSULINRSI"/>
    </dbReference>
    <dbReference type="SMART" id="SM01244">
        <property type="entry name" value="IRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00310">
        <property type="entry name" value="PTBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51064">
        <property type="entry name" value="IRS_PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0221">Differentiation</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="IRS-type PTB" evidence="5">
        <location>
            <begin position="140"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="243"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="246"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAE1244076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="299" mass="33486" checksum="B0B16077CD976FBD" modified="2021-09-29" version="1">MFPHRLSTNAGLLFLCPPPPTPSIAVFMHMAHSYDVSAAMSLCFSSTPTLSQSSQGIFKKVVILEILLLHFSPHFSCPPPPLHPLSIISFSSSPLSLFLSFSSITPHSSFLFISRVAENVDEQESWLGCLLDLQNDSYHFEYVWQVTMKPKGLGGTKNMTGQFRLCLTNREVSLVRLNSEIPEVTFQIGYIRRCGHRDCLFFMEVGRLAPTGHGELWMQVEDQATARNMHDCILGEMKNPANNAESGSFRSRSCSSSGKSIVPPQWTNNEHSSESISMFNSDQYPFNRSRTVSEGQQLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BPW8</accession>
    <name>A0A812BPW8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_21762</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000802">
        <property type="protein sequence ID" value="CAE1239348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BPW8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1239348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="292" mass="33673" checksum="02B8077BE06DFC15" modified="2021-09-29" version="1">MTNPIPNYLYTASGSNATYFSLYATASSNDGGYYYCNWWKRYFAFKHCCFYKPTHIFVFYSTTTSIYIFPPPLRPFAHSSSSSSSSSHTPRLLLLLLLLLLLSPPLFATYPTYSSLISSSSFVFLLLSLFHLPSSSFCPRLSLYSLPSLFLFLFRLTHRPHSSNYFFFFFFFSFTLLSVYYFLSLPLIFPLLLLLLLIPLNYVYPRLLPVIPPPPYFTNHLYFLSTSFSLLFCGFLSSLSLSFSLPFNSSHYLLILSSRLPPHTLLHILLLLPLPTFRPYPSSCPFFILFCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BTY1</accession>
    <name>A0A812BTY1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_22674</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000840">
        <property type="protein sequence ID" value="CAE1241141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BTY1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1241141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="240" mass="28482" checksum="6D19CFE889932E29" modified="2021-09-29" version="1">MYPTLFLSIYLSIYLSIYLSIYLSIYLCQSLSFFLSFFLSFFLSFFLSFFCLRLLKSIYLSIYLSIYLSIYLSIYLCQSLSFFLSFFLSFFLSFFCLRLLKSIYLSIYLSIYLSIYLSIYLSKSAVKIYLSIYLSIYLSIYLSIYLSIYVSSFFLSFFLSFFCLRLLKSIYLSIYLSIYLSIYLSIYLNQLYLDTYYSARNELLLFVSFSVCLSVSQCPFTFIQPPLSPLAVSLFLYLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C045</accession>
    <name>A0A812C045_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_24803</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000932">
        <property type="protein sequence ID" value="CAE1245619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C045"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1245619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="207" mass="25034" checksum="5912257169853C81" modified="2021-09-29" version="1">MFNTIFFLYISLLLYLWRHTVQDSAKILRSFASSCIFFLLFFCYFLLLTVLTFLIFLFTFIFFLSFSLFGYLSFFNFSFASFFSLLSLLPDSFAFVLSFFLFFHLCLFSFLSFHIVFSFRVSFLCFFISFILFVFHSRLYNSFPFSLSPFFFLVNFFSFLFPFIMLSHTFFHIFLNSLFLSLYFHSFVPTDFPISTYLIYLIKQKNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C0H0</accession>
    <name>A0A812C0H0_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Carbohydrate kinase PfkB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SPHA_26114</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000999">
        <property type="protein sequence ID" value="CAE1248353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C0H0"/>
    <dbReference type="OrthoDB" id="198885at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004730">
        <property type="term" value="F:pseudouridylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006796">
        <property type="term" value="P:phosphate-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01941">
        <property type="entry name" value="YeiC_kinase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1790.10">
        <property type="entry name" value="Indigoidine synthase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01876">
        <property type="entry name" value="PsiMP_glycosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022830">
        <property type="entry name" value="Indigdn_synthA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007342">
        <property type="entry name" value="PsuG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42909:SF1">
        <property type="entry name" value="CARBOHYDRATE KINASE PFKB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42909">
        <property type="entry name" value="ZGC:136858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04227">
        <property type="entry name" value="Indigoidine_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110581">
        <property type="entry name" value="Indigoidine synthase A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00583">
        <property type="entry name" value="PFKB_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="8">
        <location>
            <begin position="333"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAE1248353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="692" mass="74968" checksum="76D2E448A7F6D7FF" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C159</accession>
    <name>A0A812C159_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_27482</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001068">
        <property type="protein sequence ID" value="CAE1251331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C159"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1251331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="249" mass="29688" checksum="E923A0DE986442EC" modified="2021-09-29" version="1">MCLKFFSILYFILSFIIRISFLSLSLYLFYLFIAFLSFFFTSFRFFLIRFHAVLSSNILFFSSVYIFFILFFLSLPLSLTSLHLFFHSFSLFFILHIFHFLFSFVGPGFRYSSFIFLHFPCSSFFIYFIFFSLSLAQSLTSLHLFFHSFSLFFILHIFHFLFSFVSPVFDYYSFIFFLCFPCSSFFIFFNFISLSSAHFLTILHLFFPSFSPVLFSSYFSFSFSLSFSVSFLMALVSLLNSSAFFRRSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C1Q2</accession>
    <name>A0A812C1Q2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_27833</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001090">
        <property type="protein sequence ID" value="CAE1252071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C1Q2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1252071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="198" mass="24247" checksum="B9C34A3EA981EA1D" modified="2021-09-29" version="1">MAGRLNSFLSNAIRFCISVLFVRSFFSNNDSRFLFFFFHVCHFYYSGSSYFATFFLSFSFFLFLSFFFFLSFFNRKETFLHIHSFFVFIFSLYSSFLYNHSFFIFIVFLQSFFLYIYPLFIIVIALYSSFPYIHSFLSFFLNIHPFFTLILSLYSFLYSSFLYIHPFFIFIPFYINSFIIFILSLYQSFLILFFLYIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C4D9</accession>
    <name>A0A812C4D9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_28297</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001112">
        <property type="protein sequence ID" value="CAE1252976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C4D9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="273"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="344"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="412"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1252976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="457" mass="54611" checksum="2C776A8B7E909906" modified="2021-09-29" version="1">MTPFSSFPSLQSSLSYFLFILLLSLSPYIHPFSFFHYFSIFLFIVYFSLLSSFHYFSPLISFSHFILCLSLLSYFFLRLLFIPSFSHYPLFLFAPSIHVYLLFSFFFFSFFSFSLQIIFFPFSLQLSPYLFLFLSFLSLFAISFSLFFSILPSFLLQFTFSYVFLPFDFLPFLVPFFFQLLYLSFSPLFPFSIFLYSSFLRFFSILCFASSFFRFPFFLTFSLVAFYLSFLFSLFFFFFPTFIFNFYLTLSFFLFPFFLHFLFNFFLSLSLLPYPLSISFCLLPLSLPPSQSVVIFSFSHYPFSLPYIPVSFFFLSLSLISFPLSSSLPLSFSFPSPFSSFYSLLFSLSLLSFSLSSSLLLSFFSFPSLFLFPFSLSHFLVRFFFLFFLFPISLSHFLVRFFFLFFSFHSLFLFPFSLSHFLVRFFFLFFLFPFSLSHFLVRFFFLFFSFPSLFLTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C5D0</accession>
    <name>A0A812C5D0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_29847</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001197">
        <property type="protein sequence ID" value="CAE1255846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C5D0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="40"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1255846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="264" mass="30918" checksum="136CEE4F5E154FEA" modified="2021-09-29" version="1">MLTCSPLTSSLSLPLSLFLSHTHALFSVSHTLAIQSRTIPLFVIFSFFLFSFFFLLVSAFVFLTFPSHSFSLSLSLSNLFFLFAVLGINLSIYLSIYLSIYASLSSYASLPIYLSIYVSIYFLYPCQSTEKFCVDYVERIFFLFFHCFFSFIFLLFFFWAFLSLPLFIIISPAFYYLFFSLSFISCLSFPFSVLCCFFFLSLSFYLFLFLALSFTRFFLFSIFFSFSVFPFLFLFLSLSLSFLFLNSITISFLSFFFHTVFVFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C6J8</accession>
    <name>A0A812C6J8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_29231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001159">
        <property type="protein sequence ID" value="CAE1254881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C6J8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="186"/>
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    </feature>
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        <location>
            <begin position="193"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="238"/>
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    </feature>
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        <location>
            <begin position="264"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="312"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="340"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1254881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="367" mass="44892" checksum="D508E448C528448D" modified="2021-09-29" version="1">MTSNIFTCPFFLSLCLSLTVSLSFSLSLSLSLSLSIYLSIYLSIYLSISSSSFLHFLSFILFHPFLQFLFHLAYFFAIFYFSLHIFFYFFTSFFLFLLFYNSFYFISFLFLLLYIFLSFLFPFFLYSYTVCFSSILILSFFLFPTYVFLLHHTFYFSPFYFIFFFFFHFIFFSMLLFLFFFFYFFLVFITRSYLSFLSSTLFSLKLFLLLLFHFFSMFSSSFSRSCSYSLFHVFHRSLFALFCLSFFYYLFFSSFYLSSSSFPSFFSFFSLFSSNYFIAVNPLFPSLSILCSPSTFIFFFFFFFIHYRHHSFSPYIFFFTYNWFISSSSFFFFFNHFFLYFSFFFFTISFLLSFYFLLLFSFNHFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C8C7</accession>
    <name>A0A812C8C7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_31931</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001324">
        <property type="protein sequence ID" value="CAE1259973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C8C7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="280"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="312"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1259973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="340" mass="39288" checksum="E99379B4D8C7153A" modified="2021-09-29" version="1">MKESSMKKSKITHRQDEANIYLSIYLSIYLSISLSIYLSIYINEIIQRQISIYLSIYLSIYLSIYLSIYLSIYLSILSISVYLSIYLSIYLSIYLSIYNCHCLSAWLIIVLSPSLSLCLSIYLSIYLSIYLSIYLSIYLVHLCLSIYLSICLSIYLSIYLSIYLSIYNCHCSSAWLIIVLSPSLSLCLSIHLSIYLSIFIYLHLSIYRYMVSSLCLLIYRCLSASFSVVVHLCLSIYLSICLSIYLSIYLSIYLSIYNCHCLSAWLIIVLSPSLSLCLSIYLSIYLSIVIWSHSLCLLIYRCLSASFSEVVHLIYLSIYLSIYLSIYHSIYLSIYLSIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C8Q5</accession>
    <name>A0A812C8Q5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_29827</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001194">
        <property type="protein sequence ID" value="CAE1255794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C8Q5"/>
    <dbReference type="OrthoDB" id="5982442at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="104"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="251"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="356"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="461"/>
            <end position="738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1255794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="784" mass="92234" checksum="D797C05F9A66C232" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C945</accession>
    <name>A0A812C945_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_32424</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001351">
        <property type="protein sequence ID" value="CAE1260864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C945"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1260864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="215" mass="25043" checksum="3356195D69F8470B" modified="2021-09-29" version="1">MDCSAVLLASLSLSLSLSLSLSLSFKGPFFNFFCLSKSLSTYLNLSRVFLFLSFFLLFPQGALFLLSITFSRIPTLVEPDSLSHSDHARGFSPPFPFDIFLSFILSFFYFSYLCFYFISFSFSFFFSFILLVVFSFFHSSISLSSFLSFILLFPLFFLSLFSIFLFSFFHFSVFVFPLFSFFHSSISFSFPFSFILLFSFSVIVFYSFLYFFLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CB15</accession>
    <name>A0A812CB15_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_30231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001213">
        <property type="protein sequence ID" value="CAE1256444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CB15"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
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            <end position="136"/>
        </location>
    </feature>
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        <location>
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            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1256444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="304" mass="36281" checksum="828B9716B3B501ED" modified="2021-09-29" version="1">MANDKKEFRSCCAPSPPPSYTPSLCRLPISATSPRILPCLISLSLSLSIYLSIYLSIYNILFIIYLSIYLSIYLSIYLSIYIGREIDSIYLSIYLSIYLSIYLSIYHILFIIHLSIYLSIYLSIYLSIYLSIYLSIHTHTHTHTHIYIYIVHYLPHFNLFIIYLSIYLSIYLSIYLSIYLSIYLSITFYSLSIYLSIYLSIYLSIYLSIHTHTHTHTHIYIYRYLLQFIIYLILIYSLSIYLSIYLSIYLSIYLSIYLSIYVFLHLYVCLSLNIYTYMFVFHYIITPIRLSFSRDFYTYTFVFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CFA1</accession>
    <name>A0A812CFA1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SPHA_33104</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
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            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001386">
        <property type="protein sequence ID" value="CAE1262268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CFA1"/>
    <dbReference type="OrthoDB" id="66533at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023616">
        <property type="entry name" value="Cyt_c_oxase-like_su1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000298">
        <property type="entry name" value="Cyt_c_oxidase-like_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000357">
        <property type="entry name" value="HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052107">
        <property type="entry name" value="HEAT6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13366:SF0">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13366">
        <property type="entry name" value="MALARIA ANTIGEN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02985">
        <property type="entry name" value="HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50855">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="COX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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            <end position="113"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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    <feature type="transmembrane region" description="Helical" evidence="2">
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    <feature type="transmembrane region" description="Helical" evidence="2">
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    <feature type="transmembrane region" description="Helical" evidence="2">
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    <feature type="transmembrane region" description="Helical" evidence="2">
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    <feature type="transmembrane region" description="Helical" evidence="2">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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            <end position="658"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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            <end position="695"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="701"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome oxidase subunit I profile" evidence="4">
        <location>
            <begin position="12"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="Heme-copper oxidase subunit III family profile" evidence="3">
        <location>
            <begin position="140"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAE1262268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="820" mass="100114" checksum="1AD536BA578D2693" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CGZ6</accession>
    <name>A0A812CGZ6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_37411</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001668">
        <property type="protein sequence ID" value="CAE1271830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CGZ6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="295"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="324"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1271830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="348" mass="39385" checksum="8B23ED9FA4A455F5" modified="2021-09-29" version="1">MSRLVPVELNRPTRPDIDVAKSIVKGGEADWLAAGNHEVLTSEITRDLFSSSPLTHPLHYSPLTSASPTTTTTSPFLIPLLVIDTRAGIDSVRFSTLKPASTCTPPQPPPLTPVHQILCTMNTPIVFRAGLSLPLTLSRVLLLSLFLSVLSGSFFFLSFFLSFFLSFFLSFFLSSQLSCFPFPFFILFQFLFLSFFLSFVSFLSFLSFFLSFFLSFFLFQLIFLFSFSSFHSFPFSFFLSFFLSFFLSFSLVPTYSSPSRSVFISIFPLSTIFSLLLLLLLFLSKSNHPPFPHLSPLFISLLIPQIYLSIYLSIYLSIYLSIYLSQPDLCISLSLVLSIYLSIFFLNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CHV7</accession>
    <name>A0A812CHV7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_36325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001588">
        <property type="protein sequence ID" value="CAE1268932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CHV7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1268932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="446" mass="48225" checksum="B809FAF9A603CDA7" modified="2021-09-29" version="1">MSVASLEALDEVARGVLLTKYKSTFENMASDISAGDGLLGLLRAGDATTRRRSRVYPSLLPPPFLSLSKIPNDNALSVCLCVCLSLSLSLYLSLAFSLIKICLSFLLLSLFPSRIPRHKGPYVCLYVCLSVSSTSLSISLSLSLSQFLARLIKVCMSDSSSLSLSLSLPPFLPRIPSDKVLSVCLYLFRITIDKSRRVCLPVSLSLSLSLPPSHSHFCLSLTCIAIDKGLPLCLSLSRISIDKVLSVCLSFSLSFAFSLAFPLINVCLSFSFSPMLPNFAFSFIKVPHSVSLSVCLYSLSPSLSRAFPLIKVCLSVCLSFSRIPIDKCLSLSLSFTFPLVKFCLSVSLSLSPSCIRTDKCLSVCLSLSLSLSLSPSCIPINKCLSVFLFLSHTPSFAFPLIKVCLSVYLSISCIAIVKGLCVCLFLPLSPLSLSLSRSLVKNPPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CLT7</accession>
    <name>A0A812CLT7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_38377</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001738">
        <property type="protein sequence ID" value="CAE1273678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CLT7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="315"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="437"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="462"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="545"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="579"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="612"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1273678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="630" mass="72433" checksum="E25CBBD9854917C4" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CM04</accession>
    <name>A0A812CM04_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_38476</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001747">
        <property type="protein sequence ID" value="CAE1273851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CM04"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1273851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="170" mass="20537" checksum="A5E69DABDC07DB6F" modified="2021-09-29" version="1">MLPLPIPYYLYQYHITFTSTILSFNKYHITITSYNTIYLSIYLSICYNTIYLSIYLSIYLSIYLSIYLSITVSIYLSICLLYIEERVFLFLFHPFLLSFFLLFVCFFHSFVKYSFFLYIYSFFLSFFLTFPLSFFLIISLFCSSFFLSFFPNFLPSFFLIISLFCPSFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CMA3</accession>
    <name>A0A812CMA3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_38617</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001761">
        <property type="protein sequence ID" value="CAE1274073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CMA3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23304:SF189">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23304">
        <property type="entry name" value="SPOT2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="310"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="347"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="378"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="405"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="430"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="474"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="501"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="546"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="574"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="600"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="633"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="661"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="687"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="710"/>
            <end position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1274073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="732" mass="87803" checksum="5D046500A6C3E52D" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CP88</accession>
    <name>A0A812CP88_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific protein-tyrosine kinase</fullName>
            <ecNumber evidence="1">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SPHA_39296</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="1"/>
    <dbReference type="EMBL" id="CAHIKZ030001813">
        <property type="protein sequence ID" value="CAE1275076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CP88"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd09539">
        <property type="entry name" value="SAM_TNK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055175">
        <property type="entry name" value="ACK/TNK-like_SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049587">
        <property type="entry name" value="TNK-like_SAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22931">
        <property type="entry name" value="SAM_TNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="ACK/TNK-like SAM" evidence="9">
        <location>
            <begin position="104"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAE1275076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="190" mass="22093" checksum="2404611420BE8DE0" modified="2021-09-29" version="1">MKPFCFLHLTRERKAKSTLYIGITLSLFPCLISLLSICSVFFSTLLSVVASVLSSHYFCQYFNAESAWRHDLIPHEFVIKQSTELHWCLAAESPFTMAAMNKELHNFLVEAELEHYYSALKNELKISVLAHLKYVKDEDLMNVGMTKPEIRRLKKYYRKEMPQGAIGKIKKVSAHQKRALSYLSELFLFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CP89</accession>
    <name>A0A812CP89_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Kinesin-like protein Kif23 Arf6-interacting domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_42476</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002086">
        <property type="protein sequence ID" value="CAE1280735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CP89"/>
    <dbReference type="OrthoDB" id="2403182at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4330">
        <property type="entry name" value="Kinesin-like protein Kif23, Arf6-interacting domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032384">
        <property type="entry name" value="Kif23_Arf-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038105">
        <property type="entry name" value="Kif23_Arf-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16540">
        <property type="entry name" value="MKLP1_Arf_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin-like protein Kif23 Arf6-interacting" evidence="2">
        <location>
            <begin position="145"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1280735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="290" mass="33190" checksum="153C0CB8FD52F999" modified="2021-09-29" version="1">MQELERKLQNKSMQTKMKNEKIQLKAIYENKLQMTREKYERDMEYEKQKMERQFGARYQEKIRKLNLLKSIVNEHSSDTSTSNTNSTPSTTPRHPMKLRTFTAPATAPKPAPAPRRPVGKLPVAKSMHDLHQIGATPKSVPTSTSNPKHRRSKSSSNAEIWLEHKARNQEIDTVLQPKLKKKRSVSRLTEKDTKDVNKYCLNHQEVGSDGELCLKFYKGNVAPTVTGGCTMVFDEVEEVKCHAPGNDRKRHSSCSNIPEHENNGHWTDTEERCSYAINGYGNKKTKAFHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CS03</accession>
    <name>A0A812CS03_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_40676</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001928">
        <property type="protein sequence ID" value="CAE1277469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CS03"/>
    <dbReference type="OrthoDB" id="9635126at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1277469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="271" mass="31693" checksum="AE64F417FB92D55C" modified="2021-09-29" version="1">MLSIYLVFLSIYLSIYLSVCLSVCLFISIYLSVCSYLSICLSVHIYLLFFVCLLLISIYLFIYLSIYLSLFKSILHYLSIYLSHFVHIYLSIYLHDSFSIYLSIYLSISVHIYLFIFLYLSLSLTLLISTYQFFSICSYLSIYLSIYLSIYLSMFISISLSSCLSQSMYLSICLSIYLSILLYLFLFIYIFLFFFINLSLPTLSLTLSLFISICLSIYLFIYLSILSLSIPKSIYLQSAIGSVLLFCYMNIFFSFFYFLSNFLSSFLSFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CUJ3</accession>
    <name>A0A812CUJ3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_40430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001908">
        <property type="protein sequence ID" value="CAE1277121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CUJ3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1277121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="240" mass="26255" checksum="ED77A7F40430C8F7" modified="2021-09-29" version="1">MPTPSLSLSLSLTGIVLILSVTGFYPYSRSLPLVFLSLSVFFYSYSLSLSLILYSYSLFLSLTGFVFFLSLSLSLSGFVSILSLSDWFCIPSLYLSLFLCPLLSLSLLFLCPSVSPSGWFCVPSVSPPGFLLFPLSLFCPFCLPLAGFVSLLSPPSAGFVSLLSPPGWFCVPSVSPWLVLCPFCLPLAGFMSILSLSVFFFFIISLSLFLIFYSYPISLTCFVFLSLSLSLSGFVFFLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CYC7</accession>
    <name>A0A812CYC7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_42001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002032">
        <property type="protein sequence ID" value="CAE1279856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CYC7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1279856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="318" mass="36708" checksum="B615D8ED3EAF3ACD" modified="2021-09-29" version="1">MSLWSKTRPLASQAPSLSLSLSLSFFLSFFLSCSIIFFASSHPTILVICIIITLPSCLSFRRLSIYLSIYLSIYLFVSIYLSIYLFVSIYLSIYLSIYLSIYLFVSIYLSIYLSIYLSICLYLSIYLSICLSLSIYLSVCIYLSIYLSIYLSICLYLSIYLSVCLYLSIYLSIYLFVSIYLSIYLSVFIYLSIYLSVFLSIYLSICFYLSIYLSIYLSIYLSIYLFVSIYLSISLCLSVSISVCSNIYQFLSIYQSIYQSLSIFSFSLSLSIPYLFLTSLFISMWISIYFSLILSIFRSIRILFLDVNFFISGSGDFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CZW8</accession>
    <name>A0A812CZW8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_44612</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002280">
        <property type="protein sequence ID" value="CAE1284172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CZW8"/>
    <dbReference type="OrthoDB" id="616263at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="330"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="360"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="382"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="411"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="445"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1284172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="469" mass="54107" checksum="2987EE41F20454C4" modified="2021-09-29" version="1">MGKVQKCGTWVPHALSDDNKDQRGTISAGLLARHRSWTQATISFINMKQRKEWLSPGKQATPRVKQDLHPRYWEREARDHQGRLPFLCFVIFSSLSLSLSLSFFLALLKVVPAATLFSVFPLFTFTPFSPFLHLSLSLSLSLSLSFYALPSSLSISLSILSLFLDSFSSSFHSLPCLPLSLSHFASSCFLFSLFSLSLSLIQDLLSLLYLPLSLITLPEISLSFSLFLHGFIHTLRPRHTFLFFLFSLVRLSFVFHARPGHSLEFLFRSCHSFFFLHIFALHVLHLTFLSCFIQKIFCILFSLSLAPFISRFTADQDDKAGAPGVDTHPLFYLLFTLSYLYSIYLSIYLSIYLSIYLSQHVHYITLCLSVFFSFYLSQHVHYIAICLSLFLFLSFFLSIYLSIYLSQHVHYIAICLCFSFSFYLSIYLSIYLSIYLNTWEESDSIYLSIYLSIYLSIYLSIYLSIYIQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CZY0</accession>
    <name>A0A812CZY0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_46380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002446">
        <property type="protein sequence ID" value="CAE1287099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CZY0"/>
    <dbReference type="OrthoDB" id="6122865at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.960">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1287099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="467" mass="52703" checksum="A4FB9D5983AACF00" modified="2021-09-29" version="1">MPRCSYPINPWLLNFIVHQKKGRSATTLHVLKCIDGPFPDGSKMMLVGDGELLITAQFATDSFEKLEASEEEEIWEKSLIMVKDWDIRLLLKETKEKSEYIMDIKRFVIWYDETGLSSKNTMVPCESHPQIQENIARIWAENHPFNQLVSDPQDSDKTDNTVNSIPLTILLEEIEKGNDKSNSEEESFNLIPNAGSILTVSAENLQQKFETENIQDFIINPKDAELLEAIVEWQNGNNVSENAPEKSTSEIPVSVLAGTSTLKYQFKPSKVCQKTVVVTPTTLKRCLHQDEIMAPRPNSDAEEEEIRLFNLSSVLNEDRCSPMKDDDQSFRKNAKNVKNSSKVVPCPATNEAASVSDKSSSQEDAPNEGPPTVSHRHLLPCLVKTSLAATEKNNLLTNSLHKEAQPVEIYATCQEMFPKHASCSSLLPPSNQLTVQNNLNNIHLPKETMESINAYWSLSHNRLWQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D175</accession>
    <name>A0A812D175_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AOAH</fullName>
            <ecNumber evidence="4">3.1.1.77</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SPHA_48195</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.77" evidence="4"/>
    <dbReference type="EMBL" id="CAHIKZ030002657">
        <property type="protein sequence ID" value="CAE1290414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D175"/>
    <dbReference type="OrthoDB" id="14839at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050528">
        <property type="term" value="F:acyloxyacyl hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009104">
        <property type="term" value="P:lipopolysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.225.10">
        <property type="entry name" value="Saposin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039676">
        <property type="entry name" value="AOAH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048593">
        <property type="entry name" value="AOAH_Saposin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011001">
        <property type="entry name" value="Saposin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008139">
        <property type="entry name" value="SaposinB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15010">
        <property type="entry name" value="ACYLOXYACYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15010:SF0">
        <property type="entry name" value="ACYLOXYACYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20825">
        <property type="entry name" value="Saposin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47862">
        <property type="entry name" value="Saposin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50015">
        <property type="entry name" value="SAP_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="308"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="344"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAE1290414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="364" mass="41079" checksum="34AD2C31BFB7500B" modified="2021-09-29" version="1">MSKAAERFCSFLPNDMLAKFCKDQVQKFVPWLNNMHFLGATPDLICQTLHFCTNKKGKFCYLFPQKTLKNYYKHLPKYDKDGDLYSQNYTFRGAYWRGKDCNDSNAKIHPGVKAIDSDVNVDSNCNGIYGTDSQGRPYEDLFCKNTNQRGFAVVGDSVAAHLHIPEEWFDAKKLSKDALKDVVLSFEDEFDWPQLSGMTGFMNSIWKTIKVKTDSIYFRLWERNHCNHRDYQNIGINGKPYIKKKEDIFQSPNVDLLSLSVLSLSFSLSLSLSLYLSAFVSLSLCPCLSLSVSLCAFPFLSLSVSLSLSAFVCLSLHLCLSPALFFSLFICLSHCVPVSPSVPVSLSLYLCVSLSLYLSLSLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D2Z3</accession>
    <name>A0A812D2Z3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_45665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002366">
        <property type="protein sequence ID" value="CAE1285875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D2Z3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1285875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="292" mass="35131" checksum="5F57B68C855C50DD" modified="2021-09-29" version="1">MAFLHINIFRFLSSTNIFTSVLCYTTDYSLFIIYLSIYLNLFIIYLSIYLSIYLSIYLSLFIISLSLSLYIYIYLSQLIHYLSIYLSIYLYIYIYIYIYIYIYINLFIIYLSIYLSQPVHYLSIYLSIYFSLYLFIYLSIYLSIYLSIYLSIYHKMYLSLYFVDIYLSIYLSIYLSIYLSIYLSQPVKINQSIYLSLLKSICPFISLSIYLSQSPVKIYLSIYLSIYLSIYLSIYRCLLKSIYHNLLKSIYFQIVEIYLSIYLSIYLSIYLSIYLSISFFLYINVSLLFICS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D992</accession>
    <name>A0A812D992_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_49545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002853">
        <property type="protein sequence ID" value="CAE1292970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D992"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1292970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="280" mass="35305" checksum="DA9781952D645E43" modified="2021-09-29" version="1">MSGFSNFKLGLFARIGAKLMLFLFFFFHKCFLFIYYLFLSFFLFFPLLPFYIFTNPFFSFFLFFLFFFIFFCFFLFFLFLSFFHLLFSFHSFFFFFNFFKKIHFDFFSEHINKPDLFLLFSFFSFLFFFLFFFIFLFFLFSFAFRFFLSFFLSFHFFHPFFFFFPFFPFLSVFPFFSFLSVFLSFFHCHFDYFFHSTHKHKATRVFFLSFLFFFFFLLFPFFFFFFSFLFFLSVPLSIFFSFFLYFFFSLFSIFSFFSFFFLKNTVFLLSSLSFLSLLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D9J7</accession>
    <name>A0A812D9J7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_49702</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002877">
        <property type="protein sequence ID" value="CAE1293235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D9J7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1293235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="281" mass="33473" checksum="4EBD119956AB1A93" modified="2021-09-29" version="1">MSIISYSLSLSLSLSLMFFYHLSIYLSIYLCSSIFSCIYLFIYLSIYLSIYFILIYLFLCIYFSLLLSIYLSIYLSIYLSIYLFYLFIIYLSIYISIYLSIYFMFYISICLSLFIIYLSIYLSMFVYILVCFYLSIYLSIYLSIYLCSYLSLLVYLSYLSIYLSIYLSIYIVSSIFYLCSYYLMFLSIYLSISLFIIYLSIYLSIYLSIYVRIYLSLLLSIYLSIYLSIYLSIYLCSLLLSIYLSIYLSIYLSILQIIMILSNTKGPTSEMNADKMLIQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D9N5</accession>
    <name>A0A812D9N5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_51932</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003185">
        <property type="protein sequence ID" value="CAE1297299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D9N5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1297299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="160" mass="17937" checksum="430CCD9F91664226" modified="2021-09-29" version="1">MTTSHQQKEPKAIEKLTTKPERTKGAATAAKYKQAVAPTGVFPDSPLNKPPPNTPPYNTLPPSTPLLTILTAAPPKRGNSFREGKMPYRQRSTGELQHYLFSNSSYLSIYLSIYLSIYLLEKCLHYSFSFYLFLSFFLSFFLSLSLSLSLSLSLSISLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DBR8</accession>
    <name>A0A812DBR8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_52317</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003239">
        <property type="protein sequence ID" value="CAE1297924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DBR8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1297924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="234" mass="28361" checksum="1667FEB737D2CC83" modified="2021-09-29" version="1">MITFTNFNLIILHIRLPIYLSIYLSIYLSIYLSYCSDLSIYLSIYLSIYLSIFISPFLCNRLIISIYLSIYLSIYLSIYLSLYLSIYLSFFMSFCFYISIYLSIYLSIYLSMSFLFISIYLSIYLSFLICLHLAHPIHDKREYILPNLLNVRIFFFFFFSFSIPISLLPLPFFLSFSFSVYLLHFFFFFFFFFFFFFFFFFHISSSYSYRSFFFFLFLLFHAFLIPLFSSTSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DBU1</accession>
    <name>A0A812DBU1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GLT25D</fullName>
            <ecNumber evidence="6">2.4.1.50</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SPHA_49469</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Farmed</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.50" evidence="6"/>
    <dbReference type="EMBL" id="CAHIKZ030002835">
        <property type="protein sequence ID" value="CAE1292811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DBU1"/>
    <dbReference type="OrthoDB" id="47375at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050211">
        <property type="term" value="F:procollagen galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06532">
        <property type="entry name" value="Glyco_transf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050757">
        <property type="entry name" value="Collagen_mod_GT25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002654">
        <property type="entry name" value="Glyco_trans_25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10730:SF53">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 25 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10730">
        <property type="entry name" value="PROCOLLAGEN-LYSINE,2-OXOGLUTARATE 5-DIOXYGENASE/GLYCOSYLTRANSFERASE 25 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01755">
        <property type="entry name" value="Glyco_transf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl transferase family 25" evidence="5">
        <location>
            <begin position="171"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="395"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="396"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAE1292811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="431" mass="50323" checksum="2D3E26CE91B8941F" modified="2021-09-29" version="1">MHAFATQPLADFGPIIAPQLNVTTDSLYSNFWCGINEHGYYERTADYEPIVRWKKRGCFEVPMVHSAYLIDMRHAGSRKLSFDVPPPEYQGPFDDIIQFAFSAKYSGMTMHILNTEYFGHIMIPLDGKNTLEDEVEQFLHIKLEMLVYEPPLRKSPFIHVPERKPDKLGFDQVYVINLVRRPERRIKMIATLKELGIDAYFLDAVDGKSLNESYLKQLGVKQLPGYADPYHGRDMTMGEIGCFLSHYLIWKDIKENGYKRIIVFEDDVRFEPFFRQKLDKVVYEADYVVEDWDLIYIGRKRLYREPEPEVEGTSMLIWPNYSYWTLSYMITYNGVQKLLDADPLSKMIPVDEFIPIMFDRHPESEWKAYFFPRNLIGMSVEPLLVYPTHYTGEPDYISDTEDSTLINDDEESEETKLPTAGLNVESPKVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DD21</accession>
    <name>A0A812DD21_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_51440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003109">
        <property type="protein sequence ID" value="CAE1296422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DD21"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1296422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="322" mass="38329" checksum="875279A01C797280" modified="2021-09-29" version="1">MGFMSLRCGVSIRTPVTSDSEGFNTFFLSYLLPSFLPFFLSFFLNSFIPSFFLSFFLSLFLNSFLPSFLLSFFLSFFLSFFPSFFLSFLPPSFILSFFLSFFLSFFLSFFLSFLTPSFFLFLSFFLSFFLSFFLSFFLNSFRPSFFFLSFFLSFFLSSFLPSFLSCHKKAIFLSLHDLVFFDIHLLFFFFHSSIHPCFFFFPSFPHPFFFFSFSFIPPSILVFSFFLHSPIHSSFFLFLSFLHTSFFFLFSFIPPSILLFLSFLHTYFFFLFLSFLQPSFFFLFLSFLQPSILIFLCLFHSDHYILSSIFLSLTKSSFFFPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DDI3</accession>
    <name>A0A812DDI3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SPHA_54185</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003501">
        <property type="protein sequence ID" value="CAE1301050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023616">
        <property type="entry name" value="Cyt_c_oxase-like_su1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000298">
        <property type="entry name" value="Cyt_c_oxidase-like_su3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50855">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50253">
        <property type="entry name" value="COX3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="63"/>
            <end position="83"/>
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            <end position="115"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="165"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="191"/>
        </location>
    </feature>
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</entry>
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</entry>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003739">
        <property type="protein sequence ID" value="CAE1303723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DLE6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="321"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1303723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="432" mass="49530" checksum="D782B3FD0968EF91" modified="2021-09-29" version="1">MLDLSIYLSIYLSTTFVAGKITPFSLSFHIPPFHFLLSYLSIYLSPFSFSNLDSSVLFMYLSIYLSIYQSVYRFIYLCLFHIYLSIYLSIYLDSKMSSQQASPDPLRVPTLSQQLWPVLPHRLQVLMHLGSNRSCYDHLARLLKHGIFTVFPGISSENQYHQRQGLSLVHTAALWSDTSRTNPHHRQRRVRAEALLRGLRNADPRLSLVQHNLCTDFLFNRPTRKALLLAIAASLAAPPHYQAPVRTAIDYFGQSIRISRSIFVSLKAKKKKEIPLPSLSLSLSLSLSLSLMIRKQKFLSDSFSLKEDDKFFVHHPPRFPIYFFKVCFYLSIYLSIYLSIYLSIYLSIRNSLSFIHPFLLSLIAHSSPSRTFPLLLSHETSLSLSLSVYLKKGKISLLLSLIFAHSSPSFSFYFPSLVGCGYSHPMKCLRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DN34</accession>
    <name>A0A812DN34_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_55235</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003660">
        <property type="protein sequence ID" value="CAE1302849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DN34"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032846301" evidence="2">
        <location>
            <begin position="19"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1302849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="295" mass="33544" checksum="4566263B845038C9" modified="2021-09-29" version="1">MTSFLLLLSLFLALFLFPSPPPPPFSFYSLSSHFLFLLPFFFCFPPPPSFSFYSLSSRFLFLLPFPFLLFSFHTRFPLLLPFHSIRLPSPFPVSLLLLPFHSIPIPHPFPFPPPPPLSFYSFYSPFSCSLLLVPFHYIHLPRAFSIPPPASFSFVSHSSPFSCSLLFPFHSILLTSPSHVPSSSFFFIHFPFLTLFLLPPRPFRSIPLPRPFPVPSSSFYSPSSPLSCSLLLLIRSILFSFFLVHSSSLYFFLYFSSSFYLLFSTRCAFSSLLLSSPSFSSPPPLFLMASGSKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DNN6</accession>
    <name>A0A812DNN6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_59872</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004150">
        <property type="protein sequence ID" value="CAE1307930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DNN6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1307930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="251" mass="27009" checksum="30EDF32635ED02B4" modified="2021-09-29" version="1">MFGEDDTNSRISLSHSLFLSHTLSLSHSHTFSLSLSLSLRTVNVSHSLSLALFHSNSGFLSPLLSLSLSLSLCHWFFLSLSSPLVSSSSFLSLSLSLSATGFLSYSLSLSLSLHFYFLFFLSISLSRSNSSFLSLCLSVCLSVCLCVCLSVCLSLSLSLTPALVFLVSVCLSVCLSVSLSLYDSSFLSLSLSVCLSVSVCLSLYDSSFLSVCLSVCLSLSLSLSDSSFLSLFLSLPLFFSRFISLSLTLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DQI7</accession>
    <name>A0A812DQI7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_58597</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004013">
        <property type="protein sequence ID" value="CAE1306321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DQI7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1306321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="293" mass="32614" checksum="73D984BA55C18A49" modified="2021-09-29" version="1">MFSLHIPCLHFMYPASQMLSLHIPFVFISDAHLPSSQMLSLRTSHPGCSVCVPRIPDAQFAYLVSRMLGLHISHPGCSVCVSRIPDARFAYLPSRMLSLRISHPGCSVCISPSRMLSLRISHPGCSVCVSRIPDAQFAYLASRMLSLRISHPGCSVCVSRIPDAQFAYLASRMLTCTQSLVLSLNTFYLVSLHSVSCTFPKHFLSCELALSLLYFPKHFLSSCIQSLVLSLNTFYLVSLHSVSCTFPKHFLSCELSLVLSLNTFYLVSLHSVSCTFPKHFLSCELALSFLYFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DRF1</accession>
    <name>A0A812DRF1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_59263</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004104">
        <property type="protein sequence ID" value="CAE1307241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DRF1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="295"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="325"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1307241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="375" mass="46287" checksum="AB8CD7475B43E08A" modified="2021-09-29" version="1">MVFFLFIFLSFFLFSFFLYSFFLSFFSFLFFFFFFSFVLFLVFYSFLSFDLFSLLWFSFFLSFFLSFFSFLFSYFLSSSYTFLFLSLFLSFFLIIISFFFSFFFLPFLSFSFPYSLFIILFFLPFFPFFFSFLHRLSIFIFLIPYFLPFFLLSFFFSFFFFRFSFFSFISFLPSYIPFFSLFSIPIFFISIITISFFLSFFLSFFFFFFFSFFHFFFSSFFLSFFLFNPFSFSLLSSFHQIIPFFLSFFPSFFLSFTYSLDFLISLIFLSFFLCLSVCLSIYLSKYIYIFIYFSLSIYLSQHVCLSIYLSQHIYLYIYLSHSVDLSTYLLQSFHLSIYLSIYLSIYLSIYFYLSLSLSIYIYIYIYIYIYIYEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DS04</accession>
    <name>A0A812DS04_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_61276</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004328">
        <property type="protein sequence ID" value="CAE1309624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DS04"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1309624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="285" mass="34865" checksum="56B72588FF76129E" modified="2021-09-29" version="1">MFIIFTETFSFSSSLLRAVFNLSISFFSSFFLSFFFFLLFLFIIFLFLFFFLSLFFLFLFFLIFLFSFFFRFLSFFFLSTFLSSFFLLLFLSFLFSFFLSFAFLSLFFLFLFFLLFCLSFSFSFFHSFPFVFFFFFFLFLFFSFFLSFFFHLFNFFFFFLLFISYLFSSFISFSFFPFFLSQYPLLFPFLIRYPLLSFKTSLFHLFLVFLFFVLNNFCLPHISSHIFNRPISTFPLCFLVRHLILSAFSVPHHFFLTTFVFVSSVAAMTDDLKWKRVSLLLMHLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DS91</accession>
    <name>A0A812DS91_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_58933</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004076">
        <property type="protein sequence ID" value="CAE1306779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DS91"/>
    <dbReference type="OrthoDB" id="6157693at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF73">
        <property type="entry name" value="PROTEIN PDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="1">
        <location>
            <begin position="5"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1306779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="165" mass="18911" checksum="AD8A3F1921A5504B" modified="2021-09-29" version="1">MLQFANMDDSEKQAVVVGKSANPRCFKNVKTLPFSYFANRKAWMTSQLFTDVMKTLDRKMIAQNRKIILFLDNATCHNLLPGTNLSSIKLSFMPPNTTGLIQPLDQSIIRSFKAYYRRELVRMQIAAIDATPPVPLSEVAKQITVLKAMHMMKRAWSNRQQFKIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DSD3</accession>
    <name>A0A812DSD3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_61873</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004391">
        <property type="protein sequence ID" value="CAE1310154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DSD3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="370"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1310154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="391" mass="48048" checksum="ABFF2B97FFC1C65C" modified="2021-09-29" version="1">MWYLTVFFFLSFSFFLSFFFHFLSFSLSFIFISFIFFLSCFLSFLLYFFHFSFFHSFSFLIVLYFFLFLSFVLSFILSFFHILSFFLSFIFHSFSFFPAFYFLHFLSFIFFHLCSFLLLFLFSCLLFVFLTIFFSFFFLSFIFLSSFIFFPSSSFLLSFIFFHSFSFLHFPFFFHFLSFIFLSSFIHFLSFIFLSSFLHFLSFIFLSSFIFFPSFSFLLSFIFFPSFSFLLSFSFLHFPFSFNSFSFIHFLSFIFLSSFIFFPSFSFLLSFIFFHSFSSLHFPFFFHSFSFLHFLSFIFFSSFIFFPSFSFLLSFIFFPSFSFLLSFSFLHFPFFFPSFSFLHFLFFFHSFSFLHFPFFFHSFSFLHFPFFFHSFSFIHSFCLLSFTHFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DT69</accession>
    <name>A0A812DT69_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_61865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004391">
        <property type="protein sequence ID" value="CAE1310150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DT69"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="318"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="362"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="398"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="435"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1310150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="465" mass="54103" checksum="C55EC3680C701612" modified="2021-09-29" version="1">MYTFVYRSLTNSSCLKATVLNDLIIFISYLLFYLPPTALSLSLSIYLSIYLSIYKINSLPDSLFISIYSSLSLFISIHLSIYLSIIGAKIMTSYLSIYLSIYLSIYLSIYKITSLSLSVHIYLSIYLSIYKITSLSLSVHIYLSIYLSIYLSIYLSHYFPQKPRLRSVFVCYLRMLPGSQITRNVVQLTSYCPSVGQRFLPAIVAVLFARPTTLSSQTPNSPLPCHNQRVKRFTLSLFHFIANLNHHICLFLLTGAFCKSILSPVLSFIRSLKRSFCLPDNYQHTQRFEKTIALALFIMLSLPLCDYLSIYLSIYLSIYLSIFSLSLALCLSVSLFVSLSLCLSQTHNCTVCRHEGNEERKYFFLSSFFSFFFFHFFFPFFLFHFFLSSLLCSFLSFYFFLSSFFLSFFIISFFLSFSFISFFLSFFFISFFHPFFFLSFFISLFFLCFFLSSFLPSDVTNWQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DUT2</accession>
    <name>A0A812DUT2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_62668</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004486">
        <property type="protein sequence ID" value="CAE1311133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DUT2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1311133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="155" mass="18507" checksum="4B82EE168C5A8059" modified="2021-09-29" version="1">MGPFSKVFFYPWTLFPLLFIFFTHGRISLLFFTYVPHFPSFFTMDAFPLLFFTHGRLSLSFFTHGRLFPSFFTHGRLFPSFFTHRLLVPSFFAHGRRFLSFLPMGLFSLLFFYPWAHFSFFLLPMDDISLLSLTHGLLLPSFFTPRRLFPSFFYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DWG0</accession>
    <name>A0A812DWG0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_63758</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004577">
        <property type="protein sequence ID" value="CAE1312504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DWG0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1312504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="178" mass="19752" checksum="DF6C33D0CAF2E975" modified="2021-09-29" version="1">MEPHISSGHLVATFFDLLKAHSHLAATFFKLLKARGHLAAIFIVLLKARGHLAAIYIVLLKAHGHLAAIFIVLLKARGHLAAIFFGLLKEHGYLAAIFFDLLKTYVHLATIFFGFLMAHGHFAATFFDLPKAHGHLPAIFFDLLKTHVYLVAIFFDLLRAHGHLAAVFFGLLKVHGQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DXB7</accession>
    <name>A0A812DXB7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_64259</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004626">
        <property type="protein sequence ID" value="CAE1313057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DXB7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="347"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="385"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1313057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="413" mass="43829" checksum="45ED4E4B0851AF57" modified="2021-09-29" version="1">MASNSFLLASLSFSTAKSSSFLFFVSSSSFTVVSAFSALFIFVSMAFLFVSFFWLFSLFSFATCSAIFFVSPSLLLLPASSSFFFAAVDSPVLTSSFFFTTASSSTFLFAASFSFSFVATASFLLISISSLLLAASSSSFFLLANSSSSFFLLANSSSSFFLLANSSSSFFLLANSSSSFFLLANSSSSFFLLANSSSSFFLLANSSSFLSLPISSSSFFLLANSSSSFFLLANSSSSFFLLANSSSSFFLLAANSSSSFFLFASSSFLLAASSSFFLLATSSFFLLAFSSSSFLLAASSSSFFLAASSSSFFLAASSSSFLLAASSSSFLLAASSSFFFLLTVSSILFLSSLFTASFNCSFFFVSSCSLSFFNFSSSVFLFSSFFFSVSALLCLVSSLFSISSFFFSSSFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DXJ5</accession>
    <name>A0A812DXJ5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_64046</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004609">
        <property type="protein sequence ID" value="CAE1312861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DXJ5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1312861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="322" mass="35603" checksum="7945A5A3E9DF3A41" modified="2021-09-29" version="1">MSTYNESTISSEFYSDSLLIFSNSLLLALSLSLTLSHSLFLSHSPSHSLSHSSPSIYLSYSLSLILPLSLILSLTLSRSFSLSLSFFLPQSFYLILALSLSYSLSLTVSISFSLSHSFSLYHSLCHSFSPILSRIVSLILSPSLFLSHSLSLILSLSYSLSLFLSHSLSHCLCHSCSLTLSISFSLSLSFFLSLILSHSFSLILSLIISPSLFLFHSLSHSFAFSLILSLTLILSLSFSLSFFLPHFFCLILSVSLLSLSLTLSLSFSLSCSRFTFRKQSVTDCFSLCASLLQRHILTESHTFLSKSHSKSKSKPVSEKQKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DXW0</accession>
    <name>A0A812DXW0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_64549</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004635">
        <property type="protein sequence ID" value="CAE1313351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DXW0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1313351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="321" mass="37669" checksum="E01D3EAB94F2ADFD" modified="2021-09-29" version="1">MPHFSVFKSIIYLERIEGLPMSRGGSYLSIYLSIYLSIYLSILLLTISFSFSLSFFLSFFFCLFLSIYLSIYLSIYLSVDPTTTLSIYLSIYLSIYLSIYLSLSFHIYLSPFYFALNIFVSIYLSIYLSIYLSIYLSIYLSLFAHMGGKGYDPVAKRGYTYLSIYLSIYLSIYRFLFISIYLSIYLSIYLSIYLKSILRCKTSSFFFSLSPHTCIYLGKSIYLSIYLSIYLSIYLSIYVRLTDDLSIYLSIYLSIYLSIYLLAVYKSAHYLSIYLSIYLSIYLSIYHIGHKRMSLPLSIYLSIYLSIYLSIYLSIYHKRDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DY92</accession>
    <name>A0A812DY92_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_62528</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004476">
        <property type="protein sequence ID" value="CAE1311030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DY92"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134:SF22">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134">
        <property type="entry name" value="OS08G0543275 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1311030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="280" mass="33725" checksum="82E90667946557D2" modified="2021-09-29" version="1">MEQCNNDLSYLSIYLSIYLSIYLSIYLLESVQMYIYLSIYLSIYLSYSLSYLSIYHILFLYLCMYVCMYVCMYACMYLSIYFLFFVSIYLSIYLSYSLRIYLSIYNSLSYLSIIFPFFIYLSIYLSIYLSIYLSIIFSFLSIYLSIYLSILFPFFLSFFIYLSILFTSYLSIYLSIYHILFLIYLSYSLYLCMYVCMYVCMYLSILIASYLSIYNSLSYLSIIFSFFIYLSIYLSIYLSYSLSFFLSFFLSFFLSLSIYFIHFVSIYLSIYLSIYLSVTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DYB5</accession>
    <name>A0A812DYB5_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein uS2m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">28S ribosomal protein S2, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SPHA_62144</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Farmed</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for mitoribosome formation and stability, and mitochondrial translation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004414">
        <property type="protein sequence ID" value="CAE1310586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DYB5"/>
    <dbReference type="OrthoDB" id="2320368at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000026">
        <property type="entry name" value="28S ribosomal protein S2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00291_B">
        <property type="entry name" value="Ribosomal_uS2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_uS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005706">
        <property type="entry name" value="Ribosomal_uS2_bac/mit/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_uS2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01011">
        <property type="entry name" value="rpsB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12534">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S2 PROKARYOTIC AND ORGANELLAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12534:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="Ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00059792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00071390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00083109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAE1310586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="274" mass="31525" checksum="5ECF0E6C4997E25F" modified="2021-09-29" version="1">MANRLIRMNLLRQFFSSLPQWQKIPCHVPRPVLQARLLHHNQQLYSQSVIPAPENDVSTESLDLEQASLAHHDYFNVRNLINLKQLFTNRVHFGHKKGVRNPFMVPYIYGNRLDVDIIDLDQTLPLFKDALNFAAHIAYRKGIILFMSRNQQMMLRIEKTAEECGEYANCRYWAGGVFTNSSVMFGSVTRLPDLIIFISTLNNIFESHTAVRDAAKMCIPTIGIVDTNADPRLITYPIPGNDDSPVAIELYLRLFKRAILIGKNRRKKDEESLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E5B5</accession>
    <name>A0A812E5B5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_67379</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004884">
        <property type="protein sequence ID" value="CAE1316721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E5B5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1316721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="238" mass="27455" checksum="E4D5CBBE502F1EB3" modified="2021-09-29" version="1">MLTIGIHFILTSLSSLALSLSLSSLSLSHFLSLSLSLSLYLPIYLSISLSLSHSSFLLSLLSLSHFFLSFHLCQSSIVPISVTSLTFFLILFSIDILCLLSFYSLLSFLFFPHFFVFCHLYFEPVIFAFALSSFLTKLFVFSFFFSFFFSLAFYFYDLFNFLSFLTYHLLIFNIQTFLFYYLFILFRFFLALGTTTLFSFYSSLSLSLSLSLPFPSFFCFTSTISAHISTIFFSNFPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EDZ1</accession>
    <name>A0A812EDZ1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">SLC2A13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SPHA_73512</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005380">
        <property type="protein sequence ID" value="CAE1323587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EDZ1"/>
    <dbReference type="OrthoDB" id="4142200at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005366">
        <property type="term" value="F:myo-inositol:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF12">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="225"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="255"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="369"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="414"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="437"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="1"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAE1323587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="494" mass="55259" checksum="1252447ABCE7A8EC" modified="2021-09-29" version="1">MTCGQLCDKIGRRYMVILSTVIAIIASSIETSGLYHNLPGRILAGMSIGLSCLSIPIYLAENTVVSIRGPIIMLNMAALTLGQLLSGIAAASFFYLKNKGWRFLSGIIILPSSLQLVAFFFLPESTCFLAKKGQLAKAQKVMNLLWKELPEKEFELMISDQNENKEYKQKSSFQIFMCILQTPPVRRALLLGCSLHIINQMSGINIIIFYSGMVVKMAGVYDDTVTIWLSTIPTLINFLGTFVGFYLVERIGRRLLLLTSTAGVIVSLIMVSLAFWQIEVQSPVVSFVEPNANFTPCGMYRTCAKCVLDPLCGFCYQEHPILGPVNGSCLPALKMTNSYSKLGRCNSTFLGDHSPFHLKWQSDFCPSNFAYFIMAGQILYLLFFASGLGSLPWTICSEIYPMWARGISNSISSSIMWLFSWLMTGTFLTLIQCLTTYGTFLLMACVTLIGWVFWFLCLPETKGKSLEEAELLFTKPFFKKIKLKTEKNEEPVFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EE21</accession>
    <name>A0A812EE21_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_71324</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005219">
        <property type="protein sequence ID" value="CAE1321213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8943665at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF5">
        <property type="entry name" value="DYNEIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032944687" evidence="2">
        <location>
            <begin position="26"/>
            <end position="1518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="878"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="932"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="994"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1022"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1053"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1103"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1133"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1164"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1209"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1249"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1308"/>
            <end position="1329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1335"/>
            <end position="1357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1366"/>
            <end position="1387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1450"/>
            <end position="1469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1321213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1518" mass="170520" checksum="868AE4044750ECC4" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EE44</accession>
    <name>A0A812EE44_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_73480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005380">
        <property type="protein sequence ID" value="CAE1323671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EE44"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1323671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="254" mass="31037" checksum="43CA3C9722BA303E" modified="2021-09-29" version="1">MLPLFIDLFFLFSLQNISFFLSFFLSFFLSFFLSFPNTMLPLFIYLFIYFFFFLFKIIFSFFLSFFLSFFLSFSFQTLSQILSFSLVSFIYLFILSFQTLCVIYLFILSFFLSFFLSFFLSFFLFQTLFNFIHSFTLSFFLSFFLSFFLSFFLSFVSKHYLAFIYLFILSFFSSKYLLSFFLSFFLSFFLSFFLSFVSKHNVSFIYLFFFLFKIILSFFLSFFLSFFLSFFLSFVSKHYVAFIYFFILSFFSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EE95</accession>
    <name>A0A812EE95_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_71012</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005201">
        <property type="protein sequence ID" value="CAE1320789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EE95"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="282"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="392"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="422"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="450"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="545"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1320789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="583" mass="70323" checksum="D5F38916AFABB060" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EH23</accession>
    <name>A0A812EH23_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SPHA_73563</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005381">
        <property type="protein sequence ID" value="CAE1323709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EH23"/>
    <dbReference type="OrthoDB" id="10457754at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033039973" evidence="3">
        <location>
            <begin position="24"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="252"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAE1323709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="366" mass="41636" checksum="3F9136DDFB196ABE" modified="2021-09-29" version="1">MHLNLLNEFLLIFCAVFLMSANSLNDHSLNNTIFMYTSDGQCTFKEYNPTKVLHLDPNVDQRISADGSRSAKSTICTVTFAIKSNEKLKLSMDFLEIQTCNMTASLYLLLERNKLEKRKEFNCNTTYDHKPIYLHGGPHYYGILEINKVHFHDTKFILRAKVTIIPDLITTTHWPTTLIKGQSSTKQTSLDPSSHTLLLAIGIVIPLILLVASAFTYHVWHRSQQRLSNVNSSSFTFSRILRQRRDARRNTQRNQSQSTQQRSHIRTIGDLYGDPFDFLAWEEFFGCFSSMDFPKPVELPPYPGYDSPPPYESVVNETQGLETIIQPPPPPAPAPSVHQLRHQSTMVAMHSDSETVRSPSGMETTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EHS0</accession>
    <name>A0A812EHS0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_71454</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005235">
        <property type="protein sequence ID" value="CAE1321357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EHS0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1321357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="290" mass="34105" checksum="E09A0E17A68B019A" modified="2021-09-29" version="1">MFTADIDFQQIEIFSNNTKMFVSIYLSIYLSIYLSIYSMLWHYGLAWGEFIKIIYSSIFFCSYLSIYLGFFLSIYLSIYLSIYLSIYLSLLYLSIPVCSYLLSIYLSIYLSIYLGPFPIYLSIYLSIYLSIYLSIYLSIYLLYLSILSIYLCPSIYLSISLFVSIYPVCYLSIYLSIYLSILVLFLSIYLSIYLSIYLSLFYLYLSLFISIYICSYLSIYLSIYLSIYLSIFLHCLLNRSRDLSLIEIIYPFISFRSYLSIYLSIYLSIYLVNLSIVCSSPGLNTVFFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EKK9</accession>
    <name>A0A812EKK9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_76298</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005487">
        <property type="protein sequence ID" value="CAE1326708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EKK9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="437"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="477"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="508"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="545"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="576"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="602"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="637"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="667"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="695"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="724"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="754"/>
            <end position="773"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1326708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="858" mass="94043" checksum="C6D38BA84BEC26C5" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EL66</accession>
    <name>A0A812EL66_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_72901</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005350">
        <property type="protein sequence ID" value="CAE1322960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EL66"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1322960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="217" mass="25307" checksum="F68A7B7AF4C46240" modified="2021-09-29" version="1">MSSFSLLLLSLSLSLFLLFLSFFFTSFYFDFFHFVFIFLSLTFYNNISVHLSIFLSIYFKNYLSIYLSIYLSIYLSVYLSLLISVYLSISVCSSIYLSIYLSIYLSIYLSISVCSFIYLSIYLSIYLRSGKTITAGSVIDHHLKEAKKNNQIYRVLYLVHIRFLVKHLAIDLKKILDDDVHSLEENDCLSNVKIIISIYLSIYLSISLSLYIYISNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EN28</accession>
    <name>A0A812EN28_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_77745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005521">
        <property type="protein sequence ID" value="CAE1328188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EN28"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1328188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="227" mass="26450" checksum="21E8100EBABAE186" modified="2021-09-29" version="1">MSVQVLSIYLSIYLSIYLSIYLSQSFTYLSIYLSIYLSICCWYINDNFVTSTKSIYLSIYLSIYPSIYLSISVLYISIPLYLSIQSIYLSIGIYLSQSITYLSIYLSSIYLSIYLSPLHMYLHLSFYLKSIYLSSISVLLHISSINHLSIYLLYLSQSFTYLSIYLSIYLSIYLSISSFTYHLSIYLSIYLSISVLYISIYLSFYFNLSIYLSIYLSICCSLDIPHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ENZ9</accession>
    <name>A0A812ENZ9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_76729</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005496">
        <property type="protein sequence ID" value="CAE1327193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ENZ9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1327193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="263" mass="32400" checksum="E8085B60D070F5E4" modified="2021-09-29" version="1">MFYFRSFKPLYLLSIFLFFSSFFLSFFLLICSTSVCLNPFLSSFFLSFFFFILFSFFFSFYFFFFLFLSFLSFFLFNMFYFRSFKPLYSLSFFLSFFLSFFLSFNMFYFRSFKPLYSLSFFLSFFLSFFLSFFLSFFLLICSTSVRLNPFTAFLSFFLSSFLSFFHLICSTSFRLNPFLSSFFLSFNMFYFRSFKPLSIFFLPFFLSFNMFYFRSFKPLYSLSFFLSSFLSFFLSFNMFYFRSFKPLSIFFLSFFLSFFLSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EPJ1</accession>
    <name>A0A812EPJ1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RIC1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_76504</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005492">
        <property type="protein sequence ID" value="CAE1326973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EPJ1"/>
    <dbReference type="OrthoDB" id="6123087at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034066">
        <property type="term" value="C:Ric1-Rgp1 guanyl-nucleotide exchange factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040096">
        <property type="entry name" value="Ric1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22746:SF10">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR SUBUNIT RIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22746">
        <property type="entry name" value="RAB6A-GEF COMPLEX PARTNER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1326973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="304" mass="33346" checksum="A969DBE72877F3B2" modified="2021-09-29" version="1">MAVREVHHQFHWPLPIVTHSTYQHLKKTSPASNSTLTASCTPSDLNLINGLNSNAEYPASGTKCNLELLHGLEPSQPLTVDSISSAYASDEVFLKPQTNKNEDSSVATTEVLSDNSSWLAEQDLVADSMSFSSDLQITQELEMLSQEVANKGPPQSDLELRYLLQVVLEAGCLEWALIIAVVLRDALAVVRTVNTASMTDTPLEIVGRMREGLSYLELWAETECVGYKAFFRSIRGQIQVLDKVVDLAPTVAKLTILPVEDSPEETESSAISPVAQTIRTESIDQNCAEPLIDKEEKNNDCVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EQK0</accession>
    <name>A0A812EQK0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_77097</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005504">
        <property type="protein sequence ID" value="CAE1327651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EQK0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="256"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="268"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="332"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1327651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="361" mass="41402" checksum="2CC92F6617BA34CB" modified="2021-09-29" version="1">MMSVCLRVSFYLLDILTSLSLSFSIYLSIYLSIDLSIDLSIDLSIIWASSNHKYLSIPLTLSLSLSLSLSLSIYLSIYRSIYRSNASFEHLQIISLSISLSHTLSLSLSLSLSIYLSIYLSIYRSIYHLGIIKWALNHKYLSIPLTLSLYRSIYRSIYHLGIIKLPGGLFVFCDTSCSTFGPTYDRDTFLPQASHLVFLINPPEIYIYKTDDVCLSTYLSIISLSLSLSLSLSLSLSLSIYLSIYLSIYLSIYHLGIIKWALNFHCKFACLSIYLSIYLCSSVPFYSSAYYINMSIIYLSIYLTYTYTSIYIRLINLSIYRSIYLSSSWPLIIYLSIYLSIYLSIYLSIYLSICYFTSRSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EQS6</accession>
    <name>A0A812EQS6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_78372</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005537">
        <property type="protein sequence ID" value="CAE1328742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EQS6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1328742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="320" mass="36339" checksum="80057B36F8A5B939" modified="2021-09-29" version="1">MIKSPTHPSFLPSFLPSFLPSFLPFILSSPLSLSLIRTHICAHTKTYGNYLPNLTTTSHYNVSLVCFSRVVNTREPIQSPSASSRDDNRGAFFFFFSFFFLFSFFFLFVIAARLRTRVCSMKGAPPTGTDTIKMTSPLWGNGSTKPLVTDSCHFVFFSFILHVPSSIYLSIYLSIYLSIYLSIYLLAGILIFCFYFFFFPSPCLLFLYPSPFLLIIYLFTSFLCLLPFSLNPPIFAFLLFFFFFFFFFFFFFFPGLDDSFSSSFSSSSSSSSSSSSSEKLVQLRQIYFDVDIILSLFLSLSLSLSLSLSLFSIANVLQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ES27</accession>
    <name>A0A812ES27_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_81301</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005630">
        <property type="protein sequence ID" value="CAE1332249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="93"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="496"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="527"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="579"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
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        </location>
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        <location>
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            <end position="1233"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="1265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1271"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1305"/>
            <end position="1324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1336"/>
            <end position="1355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1332249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1408" mass="163079" checksum="6D41269F5BD42FC1" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ESD7</accession>
    <name>A0A812ESD7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_78402</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005538">
        <property type="protein sequence ID" value="CAE1328784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ESD7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="213"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="116"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1328784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="264" mass="28515" checksum="306E01CF2AEC8348" modified="2021-09-29" version="1">MFCQPGCCFVEEGCILQHLLFCATTTRFDAADRTKQPTSAAAAAAAAAAACRPNLNSSSGPTQPQQQQRADPTSAAAAAAAGRPNLSSSSGPTQPQQQQRADPTSVAAAAGRPNLSSSSGSTQTQQQPNMICDTTHLHDCHSKDEQATPASPPILSLHKRRRALYKRADTRESTGPRIPSFLNFPFLSCSVLSSFHSSEADDKALESGNAYSLSLSLSLSLSLLFFLFLSFFLSFFFFFFPSFFVIKTHGSFLILVEIIWFILF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EUQ2</accession>
    <name>A0A812EUQ2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_81255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005628">
        <property type="protein sequence ID" value="CAE1332178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EUQ2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1332178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="169" mass="19529" checksum="BBCC174719BA555A" modified="2021-09-29" version="1">MYVSIYLSVLSSLSIYQSLYISLSNYNCITASIYLSIYLSIYLSIYLSVSPLISSVSLYLSPIYIYIYIYIYIYIFISPSPSIYVYSYLSIYLSIYLSIYLSIYLSIYLSMILPRDLILSIYLSIYLSIYLSMNLPRDLILSIYLSIYLSIYLSASVLFCLSDLYSGSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EUW0</accession>
    <name>A0A812EUW0_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heme-copper oxidase subunit III family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_77605</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005519">
        <property type="protein sequence ID" value="CAE1328059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EUW0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000298">
        <property type="entry name" value="Cyt_c_oxidase-like_su3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50253">
        <property type="entry name" value="COX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="279"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="324"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="355"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="390"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="431"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="466"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="493"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="520"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="560"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="638"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="679"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="718"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="764"/>
            <end position="789"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="801"/>
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        <location>
            <begin position="843"/>
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            <begin position="880"/>
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            <begin position="912"/>
            <end position="936"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="943"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="996"/>
            <end position="1023"/>
        </location>
    </feature>
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        <location>
            <begin position="1035"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1077"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1112"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1188"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1224"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1253"/>
            <end position="1275"/>
        </location>
    </feature>
    <feature type="domain" description="Heme-copper oxidase subunit III family profile" evidence="2">
        <location>
            <begin position="113"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1328059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1276" mass="151554" checksum="CC652A0C4622C0A0" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EWE3</accession>
    <name>A0A812EWE3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_79943</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005584">
        <property type="protein sequence ID" value="CAE1330648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EWE3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
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        <location>
            <begin position="42"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="301"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="339"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1330648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="371" mass="44956" checksum="3D04594400B3446C" modified="2021-09-29" version="1">MSCVSIYLSIYLSIYLSIYLSLLISNNLYLHLSIYLSIYLSIYLSISACSYLSIYLSIYLSIYLSISACSYLSISGSSLSIYLSIYLSIYLSIYLSQALRYLSIYLSIYLSIYLSIYLSHLVSIYLSIYLSIYMVAFFLFSFFLSFFFFLSFCIFRFFPFLIYLIPFCIFRRISFLFSFLSFFSFFLFFEKFSFPFFYLYLIPFCNSSYSFFFFLSFFLFCIFRRNSFSFPFFFFLSLFPFFPIVLFFLSFLSFFLFIFRNSFSFPFFFLSLFNSFLNSHRIILSFFLSFFLYFPSKFFSFFLFYLYLIPFCNSHLIFLFLSFFFSYLYLIPFCNSHRIILFLFFLSFFLSIPFFFVLSVCLSFFLSFFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812F2S3</accession>
    <name>A0A812F2S3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_81595</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005639">
        <property type="protein sequence ID" value="CAE1332572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812F2S3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032626311" evidence="2">
        <location>
            <begin position="21"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1332572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="238" mass="28902" checksum="F184C1CCDCB2D67E" modified="2021-09-29" version="1">MHFIFHFLSCLLSFFLSSLSSLYLSFSFYHSLSIYHPLSFYNSFYNSLSFYHSLSFYHSLSIYHPLSFYHSLFTIQFLFTILFLFTIPFNYHFLFTILLLFTIHFLFTIPYLPSNFFLSFSFFLPFPLFLSFSFCHSLSIYHPLSFYNSLSFYHSLYLSFSFYHSLSIYHPLSFYHPLSFYHSLYLSFSFYHSISIYHPLIFFTILFIILFLFNIHFLFNLLFSFYHSLFFPSFSLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AMH9</accession>
    <name>A0A812AMH9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_2155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000061">
        <property type="protein sequence ID" value="CAE1147567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AMH9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="316"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1147567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="368" mass="46133" checksum="C0667B25470698FA" modified="2021-09-29" version="1">MIFSRTLSLSLSLSLSLSLSIYLSISFSLSLSLYLSLPPSLSLFTYIYIYTHREKGFLHTYVLSLPLPLPSLSISISLPLSLLSIAFSLSLYIYIYIYIYIYFLYIIVVLSFPFFSVFFSFSFVFFFLFFLVFIFLLLSYFFFNSFLFFFLVFFYFLFLLFFFYFLFLLFFFYFLFRLLFSFFFFFFLLLSRFLFPLFLLLSFSFSSFSSFFFYFLVFFFPLFLLLSFSFTFSFFLFFFFYFLFRLLFSFFFFFFLLLSFSFTFFLSFPSFFLFIFLFFFFFTFFLFFFFLFFLFLFTFFFFSFPLFLLFRFSFSFTFFFVLLFSFLFFFFFFLLFFFLFFFFLFLFYFSFFFSFFSSFFFYFLFRFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AQA8</accession>
    <name>A0A812AQA8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_2316</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000064">
        <property type="protein sequence ID" value="CAE1148061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AQA8"/>
    <dbReference type="OrthoDB" id="7474354at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1148061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="478" mass="54186" checksum="DB4A4063C74AEB2F" modified="2021-09-29" version="1">MKKPYVHCGSLLSVDEQRRCIMCYSLPHQSYSLRHLGYSLPHQSYSLRHLGYSLPHLGYSLPHLGYSLHHLGYSLPQLGYSLRHLGYSLPHLCYSLPHLGYSLPHLGYSLRHLGYSLPHLGYSLPHRLFSSSPRLFSSSPRLFSSSLGLFSSSTRLFSSSLRLFSSSLMLFCSSPSYSLRHLGYSLRHLGYSLPHLGYSFCHLGYSSSPRLFSSSLRLFSSLPRLFSSSLRLLSSSLRIFSSSPRLFSSSPRLFSSSLRLFSSSPRLFSSSLRLLSSSLRIFSSSPRLFSSSLRLFSSSPRLFSSSLRLFTSSLRLFSSSLRLFSSSTRLFSSSPKVILFLTGYSLRYSLPHLGYSLRHLGYSLRHLGYSLPHLGYSLPHLGYSLRHLGYSLPHLGYSLPHLGYSLRHLGYSLRHLGYSLPHLGYSLPHLGYSLRNLGYFLPHLGYSLPYLGYSLRHLGYSLRHLGYSLRHLGYLFLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ARY2</accession>
    <name>A0A812ARY2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_4365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000138">
        <property type="protein sequence ID" value="CAE1155069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ARY2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1155069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="280" mass="31903" checksum="6918F7AF152B656E" modified="2021-09-29" version="1">MRLWYACRQCLSFSLTLSLSLSFPFSFTLSLSLCHFLSLFMSVCLFLSVTVIFYLSFTLSLYHFLSLSLSLFGSVCHSLSRSLCNFFLSFFHFLSLSLSHSLCLSVIFFLSLSLCHSLSLWHCHFLSLFLLLSLCHFLSFSLSLSRSLCHFFTLYFTFTFTFSLSIKPSFPQFISLSLSLSLSLSVCLSLSRSLSFSLSLSFTLSLSITFSLSLSVTFFLSICHPLFQSLCPFLHSFFHFLTLCHTLSLFVTFSLSVLLSLSVTFSFSLSNLLFFIYDTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ASU4</accession>
    <name>A0A812ASU4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_3738</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000113">
        <property type="protein sequence ID" value="CAE1153207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ASU4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="284"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="333"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="406"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="428"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1153207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="472" mass="57497" checksum="C73F91A86664E57D" modified="2021-09-29" version="1">MKKSKQRIKREKKSFCCFPLFPITLFFSFFLNSCLLSFFLSFFLSFFLSFFLSFHSFSHLYLAFCLSLYSFFLSFFLSFFSLILICLFLSFLSSQFVFFFHHSLYSFFLSFFLSFFLSFFLLIHLSLYSFFLSLFAQNSLYYLFDFLSFFLSFFLSLLKIPYITYLLFFFVLSFSFFLSFFLFFLFFSFFAQIPSITYFLFLSFFLSFFLSFFLSFFLSFFAQKFPLLLISFSFLSFLSFFLSFFLSLLKIPYITYLLFFLLSFFLSFFLSFFLSLLKIPSITYFLFFLSFFLSFFLSFFLCSKLPLLLISFSFFLSFFLSFFLSFFLCSNSLYYLFPFFLSFFLSFFLSFLLKFIYYLFAFLFVLSFFLFSFFSQNSLYYLFPFLAFFLSFFLSFFLSFFAQNSIYYLFAFLAFFLSFFLLIHLSFLYSFFLSFFLSFFSFFLLFHLSLYSFFLSFFPSFFLSFFHLSVSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AUE9</accession>
    <name>A0A812AUE9_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TLC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SPHA_7127</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000229">
        <property type="protein sequence ID" value="CAE1162002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AUE9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="332"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="363"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="7">
        <location>
            <begin position="191"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAE1162002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="388" mass="46805" checksum="E064D2BF6D659127" modified="2021-09-29" version="1">MSLQIELTFRLLLVWSWMKFFPLEKNLSIPADPCLISFSKATALKLLDSLEAIVVCMLADLGVALASSIVDCLRDGGDEPVGPNGRRTKIVGLSFSTRLVLYSYFFLSFSFFYFFLSFRYFFFSFLSLSYFFLFSFFLFFLYLVLLFLSFFFLLLFLSFFLFFLYLVLLFLSFFFLLLFISFFLLFLFLFSFFILFLSFFFLSLLSLFSTLISFFLFPSFISFFLSYSYFFLSFSFFYFFLSFCYFFFSFLSLSYFFLYSFFLFFLYLVLLFLSFSYFLFSFFSFLSNFFLSFSYFFHSFSFSYFFLSFFSSLIISLISLFPIFLSFFLFSLYFFLLFLLFLFLSPFSFFFLSFFFFLHLLSLFFFSSFLSFLLFSLIYLLPDSFLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AUJ9</accession>
    <name>A0A812AUJ9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_5388</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000180">
        <property type="protein sequence ID" value="CAE1157795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AUJ9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="347"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="384"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="432"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="457"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="484"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="514"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="551"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="589"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1157795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="616" mass="73695" checksum="7B3C42F211F359DD" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AV50</accession>
    <name>A0A812AV50_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_5600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000184">
        <property type="protein sequence ID" value="CAE1158465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AV50"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1158465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="249" mass="29563" checksum="2DEC0902A9B4C939" modified="2021-09-29" version="1">MLHWPYLSIYLSIYLSIYLSIYRSIYLSIYLSEAIHMLHLAYLSIYLSIYLSIYLSIYIYICVCVCVTRFKWQAVKMPHWPYNLSIYLSMGIHITHLVYLSIYLSIYLSMGILMPHLVYLSIYGDSHATFGISIYLSIYLWGFTYHIWYIYLSIYLWGFTCHIWYIYLSIYLSIYLSIYLSMDSHATFGISIYLSIYLSIYLSIYGDSHTTFGISIYLSIYGDSHATFDLSIYLSIYLSIYLSIYLHIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AW07</accession>
    <name>A0A812AW07_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_4787</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000156">
        <property type="protein sequence ID" value="CAE1156472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AW07"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032693474" description="NADH dehydrogenase subunit 2" evidence="2">
        <location>
            <begin position="17"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1156472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="239" mass="28196" checksum="7709496896A4FC61" modified="2021-09-29" version="1">MVSLSLSLSFPSFCLSFSFLLSLHSSPLSLIVFSCFFHYFCILISLVFFLPFCFPSEFSSFYIYCPHFFLICLLSLQKSCLFSFLIYFYLFAYLFIYFGFLLVFLLDLFLFFLSFFIPDFFFVLSLSFMIFFLFSIAILSINSIFTLLLAPFDCLCLFYFRPSLQTSISISLSLSLSSLALYFWPYFIFLSFFLLLSISNFTIFFILFYSVSPFFAISFLSLFYLPLTFCFQPFLCTRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AWG0</accession>
    <name>A0A812AWG0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_6545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000214">
        <property type="protein sequence ID" value="CAE1160757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AWG0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="290"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="325"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1160757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="351" mass="42152" checksum="EBDFE58BABDFC391" modified="2021-09-29" version="1">MSLLLLSFHLLISFSSSYLVSFRHFIYFLLKNFFHSCYFLIFFSPLFSLFNKLPISFLSKSFFFLFLHDFLPHLSFLSVYADPSFLAFLFKFFTYFLTSQLFYSLIFSLLVFSLPIFHLFHELSPFIFFASRQHSFAQSTSSAILINYTILTKTFSLTISYLSTFLTLDDFFSFSFPLFHFFFILSISNLTYLFIPNKYFIFFLFLPLFRSFIHPFFFFRPLLVYILYFKILPIYSFLAYISYFSSSFLFFVHSFRLFYTSAFLFLSKPSCSFSTSISFFFLFVHVSFSLSLAICFAINFFHFSFFSFFMYSYAYFPSLRRFTCLSLASFLIVYQTHIDHSFLSFFFFFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AXF0</accession>
    <name>A0A812AXF0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_7065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000226">
        <property type="protein sequence ID" value="CAE1161909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AXF0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="311"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1161909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="364" mass="40416" checksum="7A47BBC298363C34" modified="2021-09-29" version="1">MLPFFFVNISLSLSLSLSLYLYLSISISLYLSLSLSLSLSIYIYIYITLPLSLSLYLSLPLSISLPLSISLFLSLSFSISLPLSIYLSLSPSIYLSPSLSLSSSIYLSLPISLSIYLSISLSSIYLSLYLSLSPSIYLSPSISLSPSIYLSLPLSIYLFLPLSISLPLSLSPSIYLSLPLYLSISLSPSIYLSLSSIYLSISLSLSLSSIYLSLPLSIYLFLPIYLSISLPHLSLPLSISLFLSLSFSLSLSLSLSLYLSISFSLYLSLPLSVYSSLSPYFCSLFLSISVYSDLSVLFFTPGKTIFSSIYLSCLTLFLISIYFSIIFSLFFISIYLSIFLSSKLSFLFFFLSFFLSFFQISLFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AZ84</accession>
    <name>A0A812AZ84_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_7745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000249">
        <property type="protein sequence ID" value="CAE1163632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AZ84"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1163632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="272" mass="33430" checksum="746A7DE8A961B794" modified="2021-09-29" version="1">MAVVTAFAMVHISFNSFFHFPIIFFLSFFFSFLFFIISHLFFFLFSRFFTSSFLSLSYLIAFLHSFFHFSFVISHNSFFLSFFLQYILSYSFFSLTISYLFFFLFLYFFLSFFLSFFLSFIFLRYISYNSFFLYSISHHILFLSFFLSFFFLYFIILYPIIFSFFLSFFFLSFFLYRISHHILSFFLSFFLSFFLYSISHHILSFFLSFFLSYIPFIYLFTFSRFLLLCLSFLYIFFYFSFSIAHDIHSFIHSFIFLSYSFSLYHHILSSMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B101</accession>
    <name>A0A812B101_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_9341</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000300">
        <property type="protein sequence ID" value="CAE1167340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B101"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1167340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="150" mass="18094" checksum="D693343CF72A11DB" modified="2021-09-29" version="1">MERWENGRWLAGWLVGWLAGWVRLVWSVSPLPYFLSSLLNFRLFVRSLVLSFFLSFFDFNSLFIASFFLSLFFFLSFFLSFFLSFFLSFLFFLSLIFNLSSLLHFSFLSFFLSFFLSFFLSLILILSSLLHFFFNSFFLSFLFFLSFFDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812B347</accession>
    <name>A0A812B347_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_9985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000320">
        <property type="protein sequence ID" value="CAE1168359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812B347"/>
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</entry>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14978">
        <property type="entry name" value="7tmA_FMRFamide_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019427">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srw"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053071">
        <property type="entry name" value="GPCR1-related_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47023">
        <property type="entry name" value="SEX PEPTIDE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47023:SF1">
        <property type="entry name" value="SEX PEPTIDE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10324">
        <property type="entry name" value="7TM_GPCR_Srw"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="289"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="331"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="66"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAE1171253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="398" mass="45937" checksum="8F0B1FF257E1C499" modified="2021-09-29" version="1">MSVSSPDLMMEDEVTSPEPTADWVTTPGLQERTNERIYRITSATDYLSVPILGYITPHLVAITVITNSLVVIVLMKRNMKSPTNCVLIGMALSDMFTGLIPMPIYVYFYTTGYYRDYMPSWSCGIYRIFTEIVPTIFHTASIWLTLALAVQRYIYVCHSFKARTWCTIDNVIKGTVVIYVFATLIQILRFFEYHYRTIEVQSVIYENKTVYGCQMVRSDWLVRWQKIYYNCYYWFRVIFVHFIPCTALVVLNALLINAMRQAKKRRELLLMQNKRSESKNIKDTNCTTLMLVAVVGLFLVVELPLGIIMLINNIQNTLDILIINHKALSVVGQIVNMMILLSYPLNFFIYCAMSKQFRNTFKQLFCGGPLPMDRECSQYMTLPTENGKTVTTGAETQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BAL4</accession>
    <name>A0A812BAL4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_16271</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000569">
        <property type="protein sequence ID" value="CAE1227058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BAL4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1227058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="197" mass="22143" checksum="E5E807D8AC029260" modified="2021-09-29" version="1">MINWFTGLSLLLLLLLLLLLLLLLLLLLLLLPTPPPSSFFFFALLPHSSSSSTSSSTFLFIIIIIFFFPILLPLHHYLVPQSSSLPFPSVLFFIILLSHLLLHRFLHPSSLPSLSLFLSLSLSFFFIMILLLYTPLLLHPPVYVHVHMCVHIFISIYLSIYLSIYLSVSHDSLSLSLSLSLSLSLSLTICVCVHANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BCW5</accession>
    <name>A0A812BCW5_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Receptor ligand binding region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SPHA_15117</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000524">
        <property type="protein sequence ID" value="CAE1178307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BCW5"/>
    <dbReference type="OrthoDB" id="6160377at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000337">
        <property type="entry name" value="GPCR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050726">
        <property type="entry name" value="mGluR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24060">
        <property type="entry name" value="METABOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00248">
        <property type="entry name" value="GPCRMGR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="544"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="Receptor ligand binding region" evidence="9">
        <location>
            <begin position="47"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="578"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="581"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="623"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAE1178307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="636" mass="73457" checksum="45E483908ABBE089" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BD59</accession>
    <name>A0A812BD59_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_16189</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000566">
        <property type="protein sequence ID" value="CAE1226797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BD59"/>
    <dbReference type="OrthoDB" id="6161790at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1226797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="185" mass="21913" checksum="52AA9FFD476A77FA" modified="2021-09-29" version="1">MRFDNLLITVCLSIYLSTSRSLYLSIYLSIYLSQSVYNCLSVYLFIYLPHYLSIYLSIYLSIYLSHSVHIYLSMSLCLYMSVYLSQSVYKYLSVYLFIYLPYSLYIYRSIYLSIYLSMSLCSYLSIYVTLFIYVCLSIYLSIYLSIYLSLFINICLSIFLSIYLTLSISIYLSIYLCQSVCIYLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BDJ0</accession>
    <name>A0A812BDJ0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_16378</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000574">
        <property type="protein sequence ID" value="CAE1227396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BDJ0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="380"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="413"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="477"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="510"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="565"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="635"/>
            <end position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1227396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="665" mass="78310" checksum="48A26350E0BCE161" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BFE3</accession>
    <name>A0A812BFE3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CUL2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SPHA_19050</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Farmed</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4 5">Belongs to the cullin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000690">
        <property type="protein sequence ID" value="CAE1233682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BFE3"/>
    <dbReference type="OrthoDB" id="27073at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031461">
        <property type="term" value="C:cullin-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000012">
        <property type="entry name" value="Cullin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000016">
        <property type="entry name" value="Cullin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000018">
        <property type="entry name" value="Cullin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.130:FF:000003">
        <property type="entry name" value="Cullin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000022">
        <property type="entry name" value="Cullin-2 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cullin family profile" evidence="6">
        <location>
            <begin position="384"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAE1233682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="802" mass="93743" checksum="BD879B858597D0B1" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BH14</accession>
    <name>A0A812BH14_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_17384</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000620">
        <property type="protein sequence ID" value="CAE1229682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BH14"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1229682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="260" mass="30958" checksum="147406D0036E8839" modified="2021-09-29" version="1">MQLCNSHFVYSCISRKLCISIYLSMSVHYLFIYRCLLIIYLSIYLSISVHYLSIYLSIYLSIYLSIYLSVYLCIYLYMSVHYLYISMTLIYLYIYLSIYLSINLSIYLSIYLSMSVHIYLSICLSMYLSIYVSSLSIYIDDSYLSIYLSIYLSIYLCLFISIYLSVYLCIYLYMSVHYLYISMTLIYLSIYLSIYLSIYLCLFISIYLCIYLSLSLSIYIYIYKILFISMYSSLSIHVDDTLSIYLSIYLSIYEILLISM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BJA0</accession>
    <name>A0A812BJA0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_18362</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000664">
        <property type="protein sequence ID" value="CAE1232134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BJA0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1232134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="158" mass="18007" checksum="EAAFB6273735D25C" modified="2021-09-29" version="1">MHHDSSMLTCHFYPKAPTPDNLIFFRQFLFFFPPTTVSFYFSLPFSLYPSFISFLSSVTLCPFSLFPFVCRPICRFSSFFLSLSLSLSLFLPSVILSFSSFLISSTSFHPFPFLSLPSFPYFLSIPFFFSLNSLSLSLSLSLSLSLSLYLSLSSNLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BKH9</accession>
    <name>A0A812BKH9_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Histone-lysine N-methyltransferase</fullName>
            <ecNumber evidence="12">2.1.1.355</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">SPHA_20442</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">Farmed</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-lysyl(9)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60276"/>
            <dbReference type="Rhea" id="RHEA-COMP:15538"/>
            <dbReference type="Rhea" id="RHEA-COMP:15546"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.355"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.355" evidence="12"/>
    <dbReference type="EMBL" id="CAHIKZ030000748">
        <property type="protein sequence ID" value="CAE1236825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BKH9"/>
    <dbReference type="OrthoDB" id="308383at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140949">
        <property type="term" value="F:histone H3K9 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10542">
        <property type="entry name" value="SET_SUV39H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023779">
        <property type="entry name" value="Chromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011381">
        <property type="entry name" value="H3-K9_MeTrfase_SUV39H1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050973">
        <property type="entry name" value="H3K9_Histone-Lys_N-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007728">
        <property type="entry name" value="Pre-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46223">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SUV39H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46223:SF4">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05033">
        <property type="entry name" value="Pre-SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009343">
        <property type="entry name" value="SUV39_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00468">
        <property type="entry name" value="PreSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00598">
        <property type="entry name" value="CHROMO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50867">
        <property type="entry name" value="PRE_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0137">Centromere</keyword>
    <keyword evidence="9 12" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 12 18" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 12 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 12 13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Chromo" evidence="15">
        <location>
            <begin position="73"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-SET" evidence="17">
        <location>
            <begin position="272"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="16">
        <location>
            <begin position="335"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="474"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="474"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="420"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR009343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR009343-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CAE1236825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="575" mass="65533" checksum="2B50ED4C12E4C740" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BP50</accession>
    <name>A0A812BP50_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_22503</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000833">
        <property type="protein sequence ID" value="CAE1240820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BP50"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1240820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="250" mass="31088" checksum="BB005AE7DAE36159" modified="2021-09-29" version="1">MDNLGAFTNLLIILFVNFWGFFFVFLLFFLSLYFLLFLSSFLSSFLFSYFSLFLHISLYLSLFIFSTLSFFLSFFLSFFLSVFIFLFLSPYFPFILYLFFLHILTSFFFPFSLHIFLSFFIFSIRSLLLSFFIFSILSFFLSFFIYFSFFFSFSFFYFFFSFFFHFFHSFFLSFFLFISFFSFFLSFFPFFLSSFFFSFFFFFSSSFFLRIFYSFFLSFFLSFFLSFFLFSYFSFFLHIVHFFFEQKIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BPS0</accession>
    <name>A0A812BPS0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_20568</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000754">
        <property type="protein sequence ID" value="CAE1237092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BPS0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1237092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="171" mass="20341" checksum="3AAC2FA74D914F1C" modified="2021-09-29" version="1">MLLYPLSVTRALILFLSFFFFYLSLSGVFLSFFRVFLSFLFSFLSLSGVFLFLSFSFPFFFLSLESFFFFPFSFLPFFRVFLSFLFSFLSLSGVFLSFFLSLSGVFLSFFLSFLFSFLSLSGVFLSFFLSFFPFFLSFFIWSLSFFLVNKVAVIGFHRLKRKKMNDYDYLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BS25</accession>
    <name>A0A812BS25_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_20674</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000759">
        <property type="protein sequence ID" value="CAE1237270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BS25"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1237270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="229" mass="26077" checksum="00BC662A423452F7" modified="2021-09-29" version="1">MATIYPSHYLSIYLSIYLSIYLSISATSYLDISLSHLSLFYLSIYLSIYLASSIYLSIYLSIYLSIYLSHFIFRYLLISSQPLLSIYLSIYLSHFIFRYLFISSQPLLSIYLSIYLSIYLSIYLSISATSYLDISLSHLSLFYLSIYLSIYLSISATSYLDISSSHLSLFYLSISATSYLDISLSHLSLFYLSIYLSIYLSIFNTAGGKIVDVMRSPVTSTGCSRDVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BVB2</accession>
    <name>A0A812BVB2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_26085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000997">
        <property type="protein sequence ID" value="CAE1248295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BVB2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="279"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="312"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="342"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1248295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="367" mass="44248" checksum="11A78007E8D42BBB" modified="2021-09-29" version="1">MNFLFLISTFFRLFLYTSFFPPFFLRFPSFLIFFSFSLFVFFLSFSFFFAYFFFLLFFRFFLFLSCLVFYFRVYFQFVLHSPIYLFFYFSHLRISFIASFFSLFFQAFSFFSSIVIFVNTSSIFFGLHSFFNCLSISFFFFPSLSSLFLISFPSSFLLSFRLRKTFLFSVLLSLFSFTFHFSFCFFLLFFIFASLFHVFIFPVHSLLSSFLPFPISRPFFSSSGTSILFLISFPFFFLHHPFLIIRFFSLFSFLFSSFFHVFFFYFFVLFPAFSSSYLFSLPLSSFTFCFSFTIVLLLFIRSFLLFCSSFFFFHLSIPFILFLLLFFLAFLHSFLLLSSACYVFFFFFYLFLLCLGFPLLPLSILLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BVZ7</accession>
    <name>A0A812BVZ7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_25022</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000946">
        <property type="protein sequence ID" value="CAE1246172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BVZ7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1246172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="159" mass="18636" checksum="E25AC8429148BEF6" modified="2021-09-29" version="1">MFVIISVWVAPPLSFSLSFSRPVFCLRVRKKLVPLVSLSIYLASTLCMSFCSCMSVYLSIYLSIYLLFRFYLSIYLSIYLSISFLIYLPAILLISFFYLSIYLSIYLSIYLYSSLVSSLFLIFVPFSIVYVFRHPSYYFRLNFMTPTPLSSSPLFFFIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BWB5</accession>
    <name>A0A812BWB5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_24745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000930">
        <property type="protein sequence ID" value="CAE1245509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BWB5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1245509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="249" mass="27776" checksum="6D47BEADFF3F5BF1" modified="2021-09-29" version="1">MSYLKICLSIISKFHSDTIPSLSPFSLFLSFSLPLSLFLSLSTYLHICLSLISKFLSATLLLSPSLYNSITPSPPSLSLYICLSLTLKFLSATLPFPSLSLSLSLSLSLSLSLCLPSFHLSFPFLSNYRSPPLSLSLSLSLSVHSFFPSLNILFTLSLLLSLSLSLSLSLSLSLRQFSSFLIHLFYLLLLFNHVFSLYILLSRSHYILASLFLHLSFSVLSPPPSPPFPLSFFFNPFFLQLSAYLSRFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BWF5</accession>
    <name>A0A812BWF5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_24811</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000932">
        <property type="protein sequence ID" value="CAE1245647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BWF5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1245647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="163" mass="19125" checksum="F8A87E9AAFD21E4C" modified="2021-09-29" version="1">MLTVFLFPSYLSLFISIYLTQFISISVPIYLSIYLSIYLSPFLHIYLLISFPSLSIYLSIYLSIYLSIYLSISIFTYLLINLIPFIIYLSIYLSIYLSIYLSISIFHSVLFVAVYLINIVNFKLSIYLSIYLSIYLSIYLSIYHPICDFIRPGEENIVYVDYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BXQ8</accession>
    <name>A0A812BXQ8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_25495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000966">
        <property type="protein sequence ID" value="CAE1247127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BXQ8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1247127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="168" mass="19940" checksum="30585452CAE8AA54" modified="2021-09-29" version="1">MYVSIYLSIYLSIYLSISVYLSTYLSICQTSIYLSVYRFQFIRLSVYLSIYLSIYLSIYLSICSYICIRVYPSVYTHTHTYMNKQTHTLSIYLSIYLSIYLSIYLSLFLSISVCLYLSIYLSIYLSIYRSIYFSLFIYLPVYRSGIHLFIYLSILVYSSIYLSIYLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812BY41</accession>
    <name>A0A812BY41_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_23868</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000885">
        <property type="protein sequence ID" value="CAE1243527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812BY41"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="329"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="362"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="390"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1243527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="442" mass="53003" checksum="88FB1CA765020233" modified="2021-09-29" version="1">MSAKSGQKFVVSCNRQRKIRDMKISVYSYSFLFLSIYLSIYLSIYLLYNYLSIYLSIYLSIYHSLFLICLPTYSLSIYINLRFTAIPFCSYLSIYLSIYLSIYLSICSNLILLSIYLSIYLSIYLSIYLSLIFIYLFIYLSQFILYLSIYLSIYLSVHISFYYLSVHISVYSLSIYLSIYLSIYLSIHISYYYLSIYLSIYLSVHISLFFIHLSIYLSLFVIYLSIYLSIYLSIYLFISQFILYLSIYLSISFYYLSISLYISLFFIYLSIYLSIYLSIYLSIYLFHFLLYLSINLFISQFILYLSIYLSNIFIAGNIFFIYLSIYLSIYLSIYLLVCFLLLVIFFYLSIYLSIYLSIYHGLFMSLFLSFYPVISIYLSIYLYIYIYILVWFVIFFLSIYLSIYLSIYLSIYIYIYIGRLFFKKCSLFYKLLSLLSALTCMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C3W4</accession>
    <name>A0A812C3W4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_31976</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001326">
        <property type="protein sequence ID" value="CAE1260026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C3W4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134:SF22">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134">
        <property type="entry name" value="OS08G0543275 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="349"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="382"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="413"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="443"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="473"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="506"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="549"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1260026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="575" mass="69462" checksum="E5CCAC989C52FE6E" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C4K0</accession>
    <name>A0A812C4K0_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_29462</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001172">
        <property type="protein sequence ID" value="CAE1255311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C4K0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1255311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="178" mass="20273" checksum="F5CC1267B481C8F0" modified="2021-09-29" version="1">MTRRQSLCLGGDRYLCKSTVFRFSLILEGRIGSLGERGVAGEELLFRCQSLEILASEKASSFVQSTASGLKTILVKSLSLSLSLSLSFSLSLFLLFPVRVNQHQIPKRFKEEEANIKNDYNDILLYSVHYLSIYLSISVYSFSIYHSLFIFYLSIYLSISVYSFSIYLSIYLSIYLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C4L7</accession>
    <name>A0A812C4L7_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SPHA_26972</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001033">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF15276">
        <property type="entry name" value="PP1_bind"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    <keyword evidence="4" id="KW-0832">Ubl conjugation</keyword>
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            <begin position="64"/>
            <end position="114"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="7">
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            <end position="599"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="7">
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            <end position="977"/>
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            <end position="1567"/>
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            <begin position="310"/>
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            <begin position="344"/>
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            <begin position="482"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
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        <source>
            <dbReference type="EMBL" id="CAE1250159.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1900" mass="209584" checksum="77E4DFB667B16DD8" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C7F9</accession>
    <name>A0A812C7F9_ACAPH</name>
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        <submittedName>
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        </submittedName>
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        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
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            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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            <end position="144"/>
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        <location>
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            <end position="259"/>
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        <source>
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        <source>
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        </source>
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        <source>
            <dbReference type="EMBL" id="CAE1255780.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="593" mass="62759" checksum="52184F2C977F9BE7" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="2">STING ER exit protein</fullName>
        </recommendedName>
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                <person name="Bekaert M."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        </location>
    </feature>
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            <end position="168"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00024237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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        <source>
            <dbReference type="Pfam" id="PF25809"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAE1257013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="178" mass="20514" checksum="FACC3BA4F8D2BBD2" modified="2021-09-29" version="1">MSLILDCPMDKLPLRKRDGARVIDSQKHAHKLTYDPDDIVYLRRSEGIEKQYRQKCKRCGLWLYYHHQGKSNVMFIVEDALRKAGEGVKTDVYSQISKPKKVTLTKHTKNMGKFSSVTVSTVDEEEEEIEAKEIADSYAANAKVIEKQLLRKGMSKRKLMEQAEEEAKKRPKGTLIDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C9H2</accession>
    <name>A0A812C9H2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_30783</name>
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    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
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            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
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        </lineage>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001244">
        <property type="protein sequence ID" value="CAE1257507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C9H2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1257507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="207" mass="24490" checksum="C9591ADD58B2F031" modified="2021-09-29" version="1">MSLPALGFVYIKRFHVAASSPLNCLPLSPSPHTHRSIKFLLHFLFYLFYYLSSSTLPLVLFSYQRNYFFLFYFYISHFCLSLFSLLSFFLFFLLHIHFLLLPFHFIVFLFLVPFHFLPLSPFFLYRTPLFFSFSFSSSATRLLLLLLLLLLLLLLLLLLLLLLLLPSLSISCLSSFLSFINSFLFTILPLFLSFRFSLHFYSVYPSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812C9U3</accession>
    <name>A0A812C9U3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_32012</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001329">
        <property type="protein sequence ID" value="CAE1260082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812C9U3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1260082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="201" mass="24753" checksum="0998B9F22D90C511" modified="2021-09-29" version="1">MLRVFSIYHFLSFFHSFFHSFFLLSFLSFFLFAFFLFFIHSFFLSLFLRSFFSFFLASFLSFLSFFFLSFHAFFLSFFLASFLSFISFFFVCIFLSFSFIFLSFFSFFLASFLSLLFSFFYLSFFFLSFLIAFFFLCLLLSFFFFLSFILLFFLSFLFASFFLFFLSFFFLCLLLSFFLFLSFFSFFFVCFFLSFFFFLTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CAW1</accession>
    <name>A0A812CAW1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_31488</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001294">
        <property type="protein sequence ID" value="CAE1259002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CAW1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1259002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="173" mass="20907" checksum="3E6BEE8861990C5E" modified="2021-09-29" version="1">MLFFASFLHFLLFLIHLFFISFIHFFFSLFASFMYLFLIFFSVSFILFRSFFFSFLFLLAFYCFFFHSFYFSVINSSFFYLFFSPLSFLSSFIFPSEILSFCFLLFFLSFCAIHFLSHSFTLEENILIHSYSYLSLSLQSLSMNIKTNTYMPYFFLVPLSFLPSLFTSIYLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CCG7</accession>
    <name>A0A812CCG7_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7041 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_36806</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001618">
        <property type="protein sequence ID" value="CAE1269918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CCG7"/>
    <dbReference type="OrthoDB" id="6159822at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055469">
        <property type="entry name" value="DUF7041"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327">
        <property type="entry name" value="ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327:SF3">
        <property type="entry name" value="RNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23055">
        <property type="entry name" value="DUF7041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7041" evidence="1">
        <location>
            <begin position="17"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1269918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="272" mass="31662" checksum="32A8BBC0DB369E38" modified="2021-09-29" version="1">MESQSSETPLATLSLNIPAFNTTNTKSWFVQIQALFDAKRITSQRTRYCYLVEKLPADIVEEVMDLLENVPDDNPYDRLKEAILKRTCASNEAMLRNLFTQVELGDRTPSQLLRHMRILLGDNKMSENIMRSLWLDKLPTTTTQILAPMTEETQTEKLADIADRIHESFRSRRVNSIQPQPAQQRDREFNDLKSTLERLSIQLQGLLQKDRQYRRDKCPGYRKRSFSRGRTDNRNRKDEICYYHKRFGPEARRCTHPCSFNNANAGNGNSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CCT9</accession>
    <name>A0A812CCT9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_33547</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001405">
        <property type="protein sequence ID" value="CAE1263058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CCT9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1263058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="255" mass="29126" checksum="064D1C07A49B179B" modified="2021-09-29" version="1">MPKFSLFHSCFSSTVSLCPFIFIRFLLLCLYLLPPCFPYLFTSFFFFFFFIRFLLLCLYLLPPCFPNLFTSSSSSSSSSSSSSLLDFFFFVYTFSLLVFPTFLTRSSSSSSSSSSSSSSFFIRFLLLCLYLLPPCFPTFLSLSSSSSSLSRPLPSPLYLFILLLFFLSLSLSLSLSRARAVQEFDISSFLNYLSLGMEEKGWKSKNDQNMCRFGARVVHCYTDPLPSSRTARFWPLLLSVLTRLTQLSPIFCQER</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CKS4</accession>
    <name>A0A812CKS4_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_36704</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030001613">
        <property type="protein sequence ID" value="CAE1269648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CKS4"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1269648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="166" mass="20308" checksum="9CFD58647F933522" modified="2021-09-29" version="1">MVNLLLSTSLSLLPHLSLFLSLSLSLSLYLSIYLSIYIYINIYLSIYLSIYLSIYLSIYIYIYIFIIFFSFYLFVFIFFLFVSLLDFFLFVFFLSFRFLSFFLFVFFLSFRFLSFFCFLSAFPFSFSFFLRFSFRFLSFRFRSFFSISFFSFSFFLFVFSFSPFIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CSS8</accession>
    <name>A0A812CSS8_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_44130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002237">
        <property type="protein sequence ID" value="CAE1283569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CSS8"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="353"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1283569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="406" mass="49572" checksum="415C94A3F038D849" modified="2021-09-29" version="1">MSQSARLSFQQGFCQPFPFFIIFLFRARALSFCLYHPFSFFFILPSFFLSFFLSFFLIYLEISHFFLLVIHSFIRFPSSLLYSSFFIFIHYLVLFLYFVFLLGIFPFPFIVTNHRLFVNKTIFSLFFNSIFDSNKNAIKYYVFFIYLFCFIPASFFLSFLCFISSSFFLLFHIVFILSFFLSFFLSFFLSFVSARIFFLLLLFHLMFFLLICLVFVLFHPLLSFFLFFFLSLFRFISSFFLSFFLSFLSCCLLLFFLLFFLLSFLFNVVIYLSIYLSIYLSLSLFIYLFFLAFYLLPFSFRFFFFLFPFDFLPIFPSFIYFYSLYNYFLLLFFYFHSFFFISSFFFSFCSLFTFLLFVVFLLSFIFFSLVYIFRLLCFYPSLPKDASILNSFPTEFFFTLRHQFQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CT48</accession>
    <name>A0A812CT48_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_42978</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002124">
        <property type="protein sequence ID" value="CAE1281605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CT48"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1281605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="264" mass="31608" checksum="1925A66B587AE46A" modified="2021-09-29" version="1">MLHRVEISIYLSIYLSIYLSIYLSIYRLFISISTYLSILFINLFKPMYASYFSLFKSIYLSIYLSIYLSIYLSIYLSIFFLPIFSFFLSLIFFSFLSFFNLFLSFFHLFLSLISFFLSFISFFLSSLSFFLSLISLIFFLSLILPSFSLFFLNIKLPSPRCLKPFYLFYSCSPLFPKLRLTNKFLFLPELLSYLFPTKRGPIIPLNTSFFLSFFRSFFLSFFRSFFLSFVLSFFLSFFLSFFLSFFLSCQIPVLRTFFLIIIFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CX89</accession>
    <name>A0A812CX89_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SYO1-like TPR repeats domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SPHA_45422</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Farmed</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nuclear import and ribosome assembly adapter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002339">
        <property type="protein sequence ID" value="CAE1285422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CX89"/>
    <dbReference type="OrthoDB" id="288703at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052616">
        <property type="entry name" value="SYO1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057990">
        <property type="entry name" value="TPR_SYO1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13347">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13347:SF1">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25567">
        <property type="entry name" value="TPR_SYO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032852819" description="SYO1-like TPR repeats domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="SYO1-like TPR repeats" evidence="3">
        <location>
            <begin position="146"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00049983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAE1285422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="412" mass="45148" checksum="E0909DCF784FD492" modified="2021-09-29" version="1">MDALLLRTLCAGLLVNIHGSELTQSAVSFSTAVLSTVAEALQLNTQALLTQAAEKIITVQANGKSAENDYADKPNEVKAVIDEMENLLRSQQIAVEIAANLCCTDDDEYEEIDSEESVSSADEMVCDVEMETENGASLSPSCLPEEIHQAFVKFNILHHVLNKIECPELPADNQLLVTDDKLKKGVHQLRVHALFTLANIISTLDLEAIGGPQCLYDICHGLVKLGGLHTGGDLDLEYVEAVSSALRAVVQKIAESKMTKFSELMSTESMSMFEMMRHCPRHEIRVNAVRILSSIGSALLSTPEAYKDLKPIGLALVSMASQDKDLHVVAEALDAIFDIFAEDDVNPIMNEIGLLDQLRKILVALKPQATASREVKRKFKDPVISTAKLNLVRFIQYKSNVTTQHTAMSCDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CY99</accession>
    <name>A0A812CY99_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MAN2B1</fullName>
            <ecNumber evidence="4">3.2.1.24</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SPHA_43679</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.24" evidence="4"/>
    <dbReference type="EMBL" id="CAHIKZ030002207">
        <property type="protein sequence ID" value="CAE1282832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CY99"/>
    <dbReference type="OrthoDB" id="2016903at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004559">
        <property type="term" value="F:alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.110.10:FF:000011">
        <property type="entry name" value="Lysosomal alpha-mannosidase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.110.10">
        <property type="entry name" value="Glycoside hydrolase 38, N terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000602">
        <property type="entry name" value="Glyco_hydro_38_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027291">
        <property type="entry name" value="Glyco_hydro_38_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050843">
        <property type="entry name" value="Glycosyl_Hydrlase_38"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11607">
        <property type="entry name" value="ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11607:SF3">
        <property type="entry name" value="LYSOSOMAL ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01074">
        <property type="entry name" value="Glyco_hydro_38N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032702132" evidence="2">
        <location>
            <begin position="22"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="401"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 38 N-terminal" evidence="3">
        <location>
            <begin position="46"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAE1282832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="422" mass="48734" checksum="E09A2A06995FF6E9" modified="2021-09-29" version="1">MFHSKAFIACLLFIFISLATTFPQRVSQPKICGYKSCNPVKEGMINVHLVPHTHDDVGWLKTVDQYYYGAKNKIQNAGVQYILDSVIQELLKDPSRRFIYVEMAFFWRWWHEQSNNMKHVVQNLVNEGRLEFILGGWCMNDEATTHYSAIIDQHTLGFDVLSSIFGDCARPRVAWQIDPFGHSKEMASLFAQMGFDGLFFGRADYQDIINRFLKKQLEMVWKANENLGDEKEREKEYEDFRLQRDPNESFVLHIPHDVDTNVFGTIVNVVDVDNVGDVDGGGGDDLTVFLSVSASSCSSLLLGQGWWKRWMLLCVQFGQSLFFLVHSILVFHSSTHLLLFLYFYSSVFYSNLFSLNISFPSIFFTISFHSFLVCFSVNDSFYPCVSYSLLSRNIFFFSGRAQTPAFHFFFFKILFYCLVSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CZ75</accession>
    <name>A0A812CZ75_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_47290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002556">
        <property type="protein sequence ID" value="CAE1288775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CZ75"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1288775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="307" mass="35410" checksum="AACC29CD379BF4CB" modified="2021-09-29" version="1">MARRHVNLCTLESLNLFISIYPFFLFHFNSLSLSACLSLSLSLSLSIYLLKFLHFYFPIWLFLSIYISLFISLSPPFSLSLSLSMYLSISFSLYIFLYLCLFLSIYLSIYLSTLPLYLFSYLSIYLSASQFISLSLYLSISFSSYLSSYLSLSIPIYLSIYFNFFISSFLSISVLIYLSIYLSIYLSIYLSVCLSVILFICISFHISLSVSISSYLSFNLSLSVPIYLSFYLYASHCISLSLSLSLSLYLFQFLHIYLPIYLCLFLSIYLSIYLSIYLSIYLSVSFSLSVPFLHAILFTYLYLSVAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812CZX5</accession>
    <name>A0A812CZX5_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_43985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002225">
        <property type="protein sequence ID" value="CAE1283263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812CZX5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1283263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="236" mass="27004" checksum="B48571CF64340DC4" modified="2021-09-29" version="1">MAWLQQRYILSSSLIFSFLSFFFTQFSFKHSLDATEIYTFFFSLDFSFLSSNTGCILSMQTVPSSPLSLLHLFPPFITSFHFFIVALPSSPPFTSSSLPSLHHLLSLLHLFPPFITSFHLFIFAGILLFLNVLLENIILCAIHSICNAALFKALNDDGWVNSLPGFFDPPSNDHYVHFLATVQFPNPTHCNRDVHFLPLFGFLLSFLLLLYTIQLITEVYTFFSGFPFSFFTQFNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D1L3</accession>
    <name>A0A812D1L3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_48356</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002684">
        <property type="protein sequence ID" value="CAE1290739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D1L3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="330"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="391"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="416"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="442"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1290739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="471" mass="57667" checksum="D5D77CF429025C0C" modified="2021-09-29" version="1">MLVKTEIYLLISNIIKTIHNSIFIFYFLLFLSIYLSIYLSIYHLLFWIDYIFYLLFLVSVCPSIFLFYLHDRIFQYILSNFFLSFSQSYISTYSFFLFFFLFFSCLYISRYFFFFLSFILSSVLSRPLSFFLFHSRIFQYILFFIFMLGDFNVLFIVFFPFFFFHVRIFHYILYFILSIIFFLNSRPHIFLSFFLNHFSFSLSFSRSYLSIHSFFLSFFNFHALSFVIFFLSFFLSFSLSYFFFIYLFFLHMFLSFFLFSSTNLSIYSFFLFFFLSFSCLYLSLYFFFLLFFLSFSLTISPPYFSLFLLFFTLKSFNIFFLSFSCSEISMYYLLLFSFLSFSCPYLSLYSFFLSFFLSFYHSFLFSRPHIFLSFFFAPSFFLSFPRSYLPFCLSLFSMFLSVNIFFLYFFSIPARIFLSFFSTPYLSLYSYSLSFSHSYISFFFTVVTFHIFFLSFFLSFFLSFFLSFFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D499</accession>
    <name>A0A812D499_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_49662</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002872">
        <property type="protein sequence ID" value="CAE1293187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D499"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1293187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="289" mass="35726" checksum="A55BFD3848AA32EE" modified="2021-09-29" version="1">MSSRVVFPHLIFLISQSFVQLYFNWFFFIPEDFKYLLQTIFYRFPPLSLFIQSSFSFHSFLQPLHPIVFFLSLYLSFFLSFSSFLFCSVTLSSVVSFFLFPVSKTIIPVGFFLLFHLIFFSVSFHIYFPSFSFIFFLLLHLYFVFFFFLYFFFFTYILIFHLYFSSSFSLISFLLHFHLYSLFFFTYFFFFFALTVFFFYTYIFFSFSFIFSFSFRLFFFTCIFLFLFHFYFCLFLFTYISSSFSLIFFLLLFHLYFFFFFTYFSFSLHLSFSSFSLIFFLLLSLIYMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D5D1</accession>
    <name>A0A812D5D1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_47800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002624">
        <property type="protein sequence ID" value="CAE1289716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D5D1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1289716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="159" mass="18353" checksum="CDDA413C850957C6" modified="2021-09-29" version="1">MLPVPFYHSTLFILLVLFCLFFFQSSSFSLSLSLSLSLFLSLSFSVHNSLFIFLNGCTRYQHMRMRIFPLFILNSFLLNLMCVYHQPDPHHVTHLLTMLFLLSLSLSLSLRVSLLPFDATPAGRQQERTFNKTNTLPCIVYDHLLTPQSAVIRHGIHFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D792</accession>
    <name>A0A812D792_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_46524</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002457">
        <property type="protein sequence ID" value="CAE1287304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D792"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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    </feature>
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    </feature>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="316"/>
            <end position="342"/>
        </location>
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            <end position="370"/>
        </location>
    </feature>
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        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="404"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1287304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="447" mass="52796" checksum="B5305B467F8DA30F" modified="2021-09-29" version="1">MLLNKQIYLSIYLSIYLSIYLSLSVPNMVNPFSFLFSFFLSFFLSFFLSFFLYFFLIFPTNPFSFLYSSFFLSFFLSFLFFQQSILFQRFFHFFFFIYFLSFYFLSIFFFFFELNVSDHVCIYLSIYPSIYLSIYYKSIYLCSCLSVCLSIYLSIYLSQSVHIYLSIYLSIYLSQSVHIYLCLFISVDFSIYDCLFYLSIYLSIYLSIYLSIYLFISIYLFIYLSLFISISVCSYLSISVSMTVYVYLSIYLSIYLSIYLSIYLSLFISIYLSIYLSIYLSLFIFISVCSYLSISLSMTVYSIYLSIYLSIYLSIYLSLFISISVCSYLLFISISVCSYLSISVSMTVYIYLSISSVHIYLCLFISVDLCMYDFMSIYLSIYLSIYLSISVFISIYVYSIYLSIYLSIYLSIYVHDCLSVCLSIYLSITTSQVFYRVIAFDSLTATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D8I3</accession>
    <name>A0A812D8I3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_48120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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            <taxon>Sepiina</taxon>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002655">
        <property type="protein sequence ID" value="CAE1290164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D8I3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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            <begin position="55"/>
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    </feature>
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            <begin position="187"/>
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    </feature>
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        </location>
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        <location>
            <begin position="399"/>
            <end position="418"/>
        </location>
    </feature>
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            <end position="458"/>
        </location>
    </feature>
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            <begin position="464"/>
            <end position="488"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="500"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAE1290164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="532" mass="64124" checksum="A77738B0BFB496CD" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812D8T6</accession>
    <name>A0A812D8T6_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_47279</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030002556">
        <property type="protein sequence ID" value="CAE1288766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812D8T6"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <end position="131"/>
        </location>
    </feature>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1288766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="221" mass="26240" checksum="F5527E26E4101A08" modified="2021-09-29" version="1">MEKNKELPCYYSASFVYLNLSIYLSISLFISIYLSIYLSIYLSIYLSISAYSYLSIYLSIYLSIPLYIIISLYLSAYSYLSIYLSIYLSIYIPIYLYLSAYSYLSIYLSIYLSLFISIYLSIYLSIYLSIYSFIYNYLFISLSLFISIYLSIYLSIYLSIYLSISVYSSLSLVFLSLFVLLHLIFPFFLSFFLSFFLSFFLHFSFFLSFFLSFFLSFFLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DCQ9</accession>
    <name>A0A812DCQ9_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidase A2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SPHA_51274</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003101">
        <property type="protein sequence ID" value="CAE1296175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DCQ9"/>
    <dbReference type="OrthoDB" id="6262499at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000130">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon opus-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055469">
        <property type="entry name" value="DUF7041"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001995">
        <property type="entry name" value="Peptidase_A2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23055">
        <property type="entry name" value="DUF7041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50175">
        <property type="entry name" value="ASP_PROT_RETROV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
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        </location>
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            <dbReference type="ARBA" id="ARBA00022695"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50175"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAE1296175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="515" mass="58704" checksum="B6A4DD1705BA4EED" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DII7</accession>
    <name>A0A812DII7_ACAPH</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_54832</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Lophotrochozoa</taxon>
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            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003607">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAE1302166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="294" mass="34500" checksum="8EF208C9A5904725" modified="2021-09-29" version="1">MKSIYLSIYLSESFQYLSIYLSIYLSIYLSISEVGEKYLSIYLSIYLSQSIHYLSIAKKMATYLVNASDSASRIDLISIYLSIYLSIYLSISVCSLSIYLSIYHLSIYLIVFITPIRVQKPLYLSLFFSYLSIYLSIYLSIYLYISIYLYRCMYANITLILKKSTPNVFFQAYIHIYLSIYLSIYLSIYTSIFISIYLSIFTIIFISIYLSTLVYSYLSIYTSIFISIYLSIYLSIYLSILVYSYLFIYTSIFISIYLSIYLSIYLSKHFDNKTFLSSSGPFFIMVCSFFLEND</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DKN0</accession>
    <name>A0A812DKN0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_54695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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            <taxon>Coleoidea</taxon>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
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    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <source>
            <dbReference type="EMBL" id="CAE1301920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="1193" mass="144267" checksum="CB31FA4C18B8DDC5" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DLF5</accession>
    <name>A0A812DLF5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_58576</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
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        <lineage>
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        </lineage>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
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                <person name="Bekaert M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
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    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
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    </evidence>
    <sequence length="367" mass="42886" checksum="1AA7CAC2CE00F6AD" modified="2021-09-29" version="1">MCVVTLSVCLSRCLSNLGVSINSTKFSFSLCILLDIPESIPPPHPPGPGNLGASLTGTYRRCDATLVLVSCIPRHIKAFKQIHLAFLGIRKCLIRGKGQFEEVTSCYVRDVRSVIVKLQTCHSSGEFLCPLPSNDAQKVFFFFFFFLFYLLISFSFTFFAILLSSSFFSSFCLIRFSSLFFFFYFVFLLIFLLIFFPFSSSSFFSSSFFLSFFFFQFCFFLFFPFVSFLLFFLLILRLSSFFLPSSSSFFFFFFFFFFFFFLSVLFFPLLSFRLLSSFFSTYSSSFFFLLFSSFFVFLLLRLSSSSSFFFLLLFHASSSYFLSSFIFFVFFFSFFLLLSTTFPSSSFYFFLLFHSFSLPFSSFFFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
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        <dbReference type="NCBI Taxonomy" id="158019"/>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
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                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
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    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <dbReference type="AlphaFoldDB" id="A0A812DLR3"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <location>
            <begin position="122"/>
            <end position="148"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAE1304032.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="151" mass="17181" checksum="0D88C5A653D8E6F9" modified="2021-09-29" version="1">MIGALAVFLVNKKSVTLAGSATGTVMTCTAIESIQNANRNFQYIYLSIYLSQSVHIYLSIYLVDCSYLSTKHAANIYLRLFTSIYLSIYLSIYLSIYLSIYLSLFTSFYLSSYLAHSIYLSIYLSIYLSIYLSQSVHIYLSIYLSIYLSMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DQR3</accession>
    <name>A0A812DQR3_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SPHA_58143</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CAHIKZ030003957">
        <property type="protein sequence ID" value="CAE1305737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DQR3"/>
    <dbReference type="OrthoDB" id="5800476at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14125">
        <property type="entry name" value="STKc_CK1_delta_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000155">
        <property type="entry name" value="Casein kinase I isoform epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000538">
        <property type="entry name" value="Putative Casein kinase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="366"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="434"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="463"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="488"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="541"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="569"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="600"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="630"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="661"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="694"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="729"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="755"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="784"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="808"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="835"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="865"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="898"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="928"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="21"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="11">
        <location>
            <begin position="444"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="312"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="312"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="323"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAE1305737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="954" mass="114016" checksum="13D4E748B2B3BD60" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DQX7</accession>
    <name>A0A812DQX7_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Defective in cullin neddylation protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SPHA_56944</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Farmed</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030003812">
        <property type="protein sequence ID" value="CAE1304327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DQX7"/>
    <dbReference type="OrthoDB" id="286637at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097602">
        <property type="term" value="F:cullin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032182">
        <property type="term" value="F:ubiquitin-like protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000436">
        <property type="term" value="P:positive regulation of protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000030">
        <property type="entry name" value="DCN1-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.200:FF:000001">
        <property type="entry name" value="DCN1-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.200">
        <property type="entry name" value="Cullin, PONY binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014764">
        <property type="entry name" value="DCN-prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042460">
        <property type="entry name" value="DCN1-like_PONY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005176">
        <property type="entry name" value="PONY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281:SF32">
        <property type="entry name" value="DCN1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281">
        <property type="entry name" value="RP42 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03556">
        <property type="entry name" value="Cullin_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51229">
        <property type="entry name" value="DCUN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="DCUN1" evidence="5">
        <location>
            <begin position="61"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU410713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAE1304327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="260" mass="30610" checksum="2EC22684F43E105C" modified="2021-09-29" version="1">MHKLKTSQKDKVRQFTACTQTSEKVAIICLGLHDWKLDVAVDNYFQDPDRYNTDHSRPPTVDKRKLDALWIRYKDPYETDKMMADGVCRFLEDLGLNPESRTVLIIAWKFKAETQCEFTREEFYQGMTELGCDTADKLRDKCPSLEQIIRDNAKFKEFYQFTFNYAKNPGQKGLDLDMALAYWNIVLADKFKFLDLWCKFLQEHHKRSIPKDTWNLLLDFCNMINDDMSNYDEEGAWPVLIDDFVEYARPLIQGCQSTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DR65</accession>
    <name>A0A812DR65_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_61151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004302">
        <property type="protein sequence ID" value="CAE1309457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DR65"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1309457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="235" mass="27642" checksum="0D5C928D391ABAFE" modified="2021-09-29" version="1">MAIIFLTLHFHLENSLIFIYSLLSFFPTNPPFFFLLNIISYFLLYSCSLSIYYTHTHSGSSTTHSLISFYHTLSHNYTIYSLHLLCLFAIAFDLSSTHYPLSLFHTLSESSTTHSHFRFLHILLFFCYLHTLCLPSVYNPRTLLLSLSLSPSLFLSLSLSLRQSLEIGYSYGCTQELFFHSFSSFTFFFLNLLVYVYMHALFFVLFGLIYSFVFFYFFVHFSSFIFYFICSFSFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DRR3</accession>
    <name>A0A812DRR3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_60974</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004270">
        <property type="protein sequence ID" value="CAE1309209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DRR3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1309209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="178" mass="21281" checksum="EC821CB07812895E" modified="2021-09-29" version="1">MPFFFFFHSAILFLFILPFFFFSFCHSSSFHSAILLFILAFFFFSFCHSSSFHSSILLLFILPFFFFSFFFFSFCHYSSFHSSILLLFILPFIFFSFCHSSSFHSSSFHSAILLLFIILLFILPFFFFSFFFFSFFHSSSFHSAIILLFILAFFFFSFYFFSFCHSSSFHSAILLISF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DWA2</accession>
    <name>A0A812DWA2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_59719</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004140">
        <property type="protein sequence ID" value="CAE1307704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DWA2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1307704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="209" mass="23035" checksum="67F3FC713553486F" modified="2021-09-29" version="1">MTQPSITPPCLSYPHNPPCPSAIHYSTMPQLSITPPCLSYPLLHHDSAIHYSTMPQPSITHHALSHPLLHHDQSAIIHHSTMTTMASITPPCRSYPLLHHDSAIHYSTMPQLSITPPCPQLSITPPCLSYPLPTMTQPSMAISYPLPTMPQPSITPPHDISYPLLHHASYPLLHHPHLSITPPCPSHPLLHHDSAAIHYSTMPQPITPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DX69</accession>
    <name>A0A812DX69_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Germ cell-specific ankyrin, SAM and basic leucine zipper domain-containing protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SPHA_64112</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Farmed</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts with DDX4, PIWIL1, RANBP9 and TDRD1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004617">
        <property type="protein sequence ID" value="CAE1312960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DX69"/>
    <dbReference type="OrthoDB" id="448455at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071546">
        <property type="term" value="C:pi-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09521">
        <property type="entry name" value="SAM_ASZ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042650">
        <property type="entry name" value="Asz1_SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24157">
        <property type="entry name" value="ANKYRIN REPEAT, SAM AND BASIC LEUCINE ZIPPER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24157:SF3">
        <property type="entry name" value="ANKYRIN REPEAT, SAM AND BASIC LEUCINE ZIPPER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10 14" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8" id="KW-0221">Differentiation</keyword>
    <keyword evidence="12" id="KW-0469">Meiosis</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="9" id="KW-0744">Spermatogenesis</keyword>
    <feature type="repeat" description="ANK" evidence="14">
        <location>
            <begin position="131"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="14">
        <location>
            <begin position="164"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="14">
        <location>
            <begin position="202"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="14">
        <location>
            <begin position="235"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="15">
        <location>
            <begin position="318"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAE1312960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="608" mass="69215" checksum="CADF3E6051248E73" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DXR2</accession>
    <name>A0A812DXR2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_64452</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004634">
        <property type="protein sequence ID" value="CAE1313260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DXR2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1313260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="414" mass="48015" checksum="A91A6AADB71677F1" modified="2021-09-29" version="1">MYYTLLSFDLSIYLSIYLSIYLSIYLSIYLSIYLLYIALSISTSLFKSIYLVFSLDLSIYLSISFKLTNIRWQTARNINARYSFHFHALRPVRMWAIAALSIFLSLSYFSPCSHPLCLCAGFYSIPFPHQEKALVRQFNRSFLCFPRDAYGQIKLVYYLSIYLSIYLSIYLSKSIFLSFFISFFLSFFLSVSQSISLLFSFFFLSLNLSFFLSFFLSCFLAFFLAFFLCQSFSDSANINPLIAFNMAVTSTHEREVIIYLSIYLSIYLSIYLSIKLTVTVLTNCGNKKSIYLSIYLSIYLSIYLSIYLSIKLAVTSRCSAIEVIKICLSLSIYQPCRYKYSPIKIKLIKIIYLSIYLSIYLSIYLSIYLSIYLSVYSFISIYPSQILSFFSLYLSPILPELILAHTKTLPPTIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812DYC5</accession>
    <name>A0A812DYC5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LIN37</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_60751</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004241">
        <property type="protein sequence ID" value="CAE1308979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812DYC5"/>
    <dbReference type="OrthoDB" id="6287771at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031523">
        <property type="term" value="C:Myb complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017053">
        <property type="term" value="C:transcription repressor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028226">
        <property type="entry name" value="LIN37"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31336">
        <property type="entry name" value="LIN37 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31336:SF3">
        <property type="entry name" value="PROTEIN LIN-37 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15306">
        <property type="entry name" value="LIN37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1308979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="233" mass="27218" checksum="A728918672D8D19F" modified="2021-09-29" version="1">MCSRKVNSARLRLNTTLQNLVEKDEESYTPSESNSPKSHDETPHRLPSPQQSPKKATFSKVSRKRKRKEDSSGSDINQYHYTYVMKLFDRSVDLAQFNENTPLYPICRAWIKNQPHNHSNQERSPSPDSDIDVKDKNIHKNGNIYHLPPPIKSEKDQCSKPRIPSPLPQTNTRIDIYADPDKAPHPKELLSNHMARWKKVRNRWRETSRQNELRYSPSLIILKEMFDSQCKDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E0L3</accession>
    <name>A0A812E0L3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_65975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004744">
        <property type="protein sequence ID" value="CAE1314964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E0L3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1314964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="359" mass="41618" checksum="BB6E7C54D7B2D52A" modified="2021-09-29" version="1">MSLFSYPTSLSLFISLILFIYLSIYPSIYPISISIYLSIYISISISSYMPIYLPSPLSSYLSIYLSIYLSIYLSIYLSIYLSIYLTLFISNYLFLFLHISHSFHIYLSIYLPQSLHIYVSIYLLSSYLSIYLSLSIYLSIYLSIYLSIYLSIYLSIISSLSIYLSIYLAPSLHFYLSIYLSIYLNLFISIYLSIYLSIYLCSLFIYMASSIFIYLSIYLSLSFITIYLSIYLSLVISKYLTLHIIYLSIYLSIYLSIYLSHLFKSIYLSIYLYLSIYLSIYLSLFIIYLSLSPLLSISLSSISIYLLLSISSSIYLSIYLSSSIYLSQSPSYPSIYLSHLNLSISLSSYLTIYLSSLHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E3A3</accession>
    <name>A0A812E3A3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_64858</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004677">
        <property type="protein sequence ID" value="CAE1313803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E3A3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1313803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="265" mass="31551" checksum="C21DE5CF293B5753" modified="2021-09-29" version="1">MRIIAHIDTQFATCGYLSIYLSIYLSIYLSSRPQSFFVSVNTEVEDPLYIYVRIINSQFIELSFTFSAFLSVLFHLLIYGYISRHLSFFQIVLFLSFFLSFFLSFYLFMFLDIYLSIYLSIYLSIYLLIYGYISRLLSFFQIVLFLFSFFLCIYLCFSMSIYLSIYLSIYLSIYQFWGIEISLVSIHVSSQHPFEDRIYHTWDDAITPQVVILQYNDVWTKLYGNRRQESHLLVPKAKEWHLPPGESQRIRNIGRNVRLCTEALN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E4I5</accession>
    <name>A0A812E4I5_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_64271</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004626">
        <property type="protein sequence ID" value="CAE1313077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E4I5"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="280"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="323"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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        <location>
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        <location>
            <begin position="489"/>
            <end position="509"/>
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        <location>
            <begin position="515"/>
            <end position="535"/>
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        <location>
            <begin position="542"/>
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        <location>
            <begin position="576"/>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="603"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="627"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="658"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="697"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="721"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="747"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="779"/>
            <end position="805"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1313077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="806" mass="97601" checksum="42EFE8BC57009732" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E522</accession>
    <name>A0A812E522_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_64568</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004639">
        <property type="protein sequence ID" value="CAE1313397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E522"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="153"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="198"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1313397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="228" mass="24905" checksum="783DDB9BCEEE7F94" modified="2021-09-29" version="1">MTSLQKQQSPKQQSPPQERPEKQKQHKEVHRKEAPHLGADWALASTRASPYSALFSHLLVLKSSLSSSSSPLPLFNDEAFPPTPYRGPVDATPQRPAVAIVGTPLPGVEVLAAVAAPAASAAVANLTAATAVLATVLAAALAASAFSCLSADLVVFLCLFLPLFSSVSVVLFLFFLYSYTYKYKQNICIHSHYLSIYLSIYLSMYLSIYLSIYVSIYLSIYVILIYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E6M0</accession>
    <name>A0A812E6M0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">GTF3C1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SPHA_67314</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
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    <reference evidence="10" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004876">
        <property type="protein sequence ID" value="CAE1316636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6262911at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042791">
        <property type="term" value="P:5S class rRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16169">
        <property type="entry name" value="Tau138_eWH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056467">
        <property type="entry name" value="eWH_GTF3C1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044210">
        <property type="entry name" value="Tfc3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035625">
        <property type="entry name" value="Tfc3-like_eWH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007309">
        <property type="entry name" value="TFIIIC_Bblock-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056428">
        <property type="entry name" value="WH_GTF3C1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15180">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15180:SF1">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04182">
        <property type="entry name" value="B-block_TFIIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24101">
        <property type="entry name" value="WHD_GTF3C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23704">
        <property type="entry name" value="WHD_GTF3C1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="General transcription factor 3C polypeptide 1 winged-helix" evidence="8">
        <location>
            <begin position="8"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="B-block binding subunit of TFIIIC" evidence="7">
        <location>
            <begin position="172"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="GTF3C1 extended winged-helix" evidence="9">
        <location>
            <begin position="529"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
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            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
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    </feature>
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            <begin position="341"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="476"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="494"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1522"/>
            <end position="1536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1844"/>
            <end position="1861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1886"/>
            <end position="1895"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAE1316636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="2042" mass="233185" checksum="8F5A1C8CD5268C95" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E725</accession>
    <name>A0A812E725_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_65538</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004724">
        <property type="protein sequence ID" value="CAE1314576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E725"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="385"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1314576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="468" mass="53478" checksum="0CFE91BEF49D534C" modified="2021-09-29" version="1">MSIQFHTFSLTSPFYFSLMFSPFSFSLTFPLYFFSFPLIFLFLPFSLMSSSDLSLSLSLARSVSLSFFLSIYLSLSLSIFSGIAIHLLHEHLSLSYLIIFFYFLFQYLLSVSPIASRPSPTIFFHRCLFYCPFTLYPHLLFPLNPPHILFPLYTLIVFSFLTTLSSYSLYSLHPPHILFPLYTLLIFSFLSTPSSYSLSSLHSPHILFPLYTLLIFSFLSTPSSYSLSSLHSPHILFPLYTLLIFSFLSIFSSYSLSSLHSPHILFPLYTLLIFSFLSTLSSYSLSSLHPSSYSLSSLPLPHILFPLYTLLLFSFLSPLSLILFPLYTPLHILFPLYLSSYSLFSLFSSFFFPLYNTSHILFPLFSPFFPSNLHILFPSNSPPPFSFLLMSLPFFSFLTLPYYISLSSPHYSLFLQFSYSLSPLPLPCSLSSLHPSTYSIFVHSNILSSSTPSSLFSFLCPSPHIPFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E8L2</accession>
    <name>A0A812E8L2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_66706</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004817">
        <property type="protein sequence ID" value="CAE1315880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E8L2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="298"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="321"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1315880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="344" mass="40974" checksum="565BF872DC93608C" modified="2021-09-29" version="1">MLLGFHVCVEFVRSVVSVLNIKVCGHLSIYLSIYLSIYLSIYLAHLFMSLTLTLYQSVHIYISIYISIYIFIISLYLFIYLYPYLSICLFHRHNYLSIYLSIYLSIYLSIYLSNTTLYLNNFFFFFFIFFLISVSFFFFFFFIIFFLFFFFFFFFFFFFFFLLLFFFYFMLFFFFFVFCFFIFLLFFSFFFLFFFFIIIIFFLSSSSSPSPFSSSSSSFSSSSSSYYPTSSSSTSFFIFFLLIFFFLLFFYVIFLLFFFTIFFSSSTSSSSSSSSLSPSFSSSSSSFSSSTFSSSSHLLPLLLHLHSLLLLFPLLPPLLLLLHLPLPLLPPLLFIFTLFFFFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E8R7</accession>
    <name>A0A812E8R7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_68844</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005028">
        <property type="protein sequence ID" value="CAE1318387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E8R7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="26"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="205"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1318387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="283" mass="32842" checksum="74A15FC98653FCA3" modified="2021-09-29" version="1">MIVSLYNNDGRFLRASISRVGDHLSIYLYIYLSIYLCYLSFFLSFFLSIYLSIYLSISVSLYLSIYLSFSVSLYLSIYLSIYLSIYLSIYLSMFISFLSIYLCFSVSLYLSIYLSQTLYIYLSIYLSIYLSIYLSISVSLSLSIYLSFSVLLYLSIYLSIYLSIYCSMFLFLISIYLSIYLRRFISIYLSIYLSIYLSISDALYLSIYLSISVSLSLSIYVHFLSIYLSQSYFLESLIEKRANSFLGSTHPIQRSKTPGGINPAPTDSRERKIRKPTSTMQID</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E9I9</accession>
    <name>A0A812E9I9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_71009</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005201">
        <property type="protein sequence ID" value="CAE1320794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E9I9"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="302"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="368"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1320794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="421" mass="49910" checksum="A76230A333CB13D6" modified="2021-09-29" version="1">MVEIATPISHAFLCPSFPSLSPAVVGRILLYEGNQNVCCVLSYKPRPRSLPIFVLLFSFLLSFLFSFHFLSSFFSFFFPLSFFSRFIYCFLLISFTTNYLAYFSFALSTLSFLTVSTLSFFLSFFLSFFHSFCSTLSFLHRVNAFFSFFLSFFLSFFLSFFLSFFLCLKPDSASDVSFLSFFLSFFLSFFLSFFHCFHAFLLSMYLFFQCIPSFFLSFFLFFFLSLYPLFLSFFLSFFLSPFFLSMYPLFLSFFLSFFLSFFLSFFLPSFFQCIHFFFLSFFLSFFLSFFLSFFLPSFFQCIHFFFLSFFLSFFLLLYLLFLCFFLNKTSLQSDYIYLSIYLSIYLSIYLSMCALTPRLVRSKMVADYIYLSIYLSIYLSIYLSICWNNFFPSLLSIYLSIYLSIYLSKVVAAVFLLSNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812E9U9</accession>
    <name>A0A812E9U9_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 24">Lysine--tRNA ligase</fullName>
            <ecNumber evidence="6 24">6.1.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21 24">Lysyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">SPHA_69494</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="27">Farmed</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="23">Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. When secreted, acts as a signaling molecule that induces immune response through the activation of monocyte/macrophages. Catalyzes the synthesis of the signaling molecule diadenosine tetraphosphate (Ap4A), and thereby mediates disruption of the complex between HINT1 and MITF and the concomitant activation of MITF transcriptional activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22 24">
            <text>tRNA(Lys) + L-lysine + ATP = L-lysyl-tRNA(Lys) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="27">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.6" evidence="6 24"/>
    <dbReference type="EMBL" id="CAHIKZ030005083">
        <property type="protein sequence ID" value="CAE1319068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812E9U9"/>
    <dbReference type="OrthoDB" id="21243at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006430">
        <property type="term" value="P:lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00775">
        <property type="entry name" value="LysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04322">
        <property type="entry name" value="LysRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000050">
        <property type="entry name" value="Lysine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000029">
        <property type="entry name" value="Lysine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00252">
        <property type="entry name" value="Lys_tRNA_synth_class2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002313">
        <property type="entry name" value="Lys-tRNA-ligase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034762">
        <property type="entry name" value="Lys-tRNA-ligase_II_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044136">
        <property type="entry name" value="Lys-tRNA-ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018149">
        <property type="entry name" value="Lys-tRNA-synth_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00499">
        <property type="entry name" value="lysS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001756">
        <property type="entry name" value="PRK00484.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918:SF9">
        <property type="entry name" value="LYSINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918">
        <property type="entry name" value="LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039101">
        <property type="entry name" value="LysRS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00982">
        <property type="entry name" value="TRNASYNTHLYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0007">Acetylation</keyword>
    <keyword evidence="19" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12 27" id="KW-0436">Ligase</keyword>
    <keyword evidence="18" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0964">Secreted</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="26">
        <location>
            <begin position="232"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00015745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00030563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00059215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="RuleBase" id="RU003748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="CAE1319068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="576" mass="65779" checksum="04D11D336DA5D874" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EA01</accession>
    <name>A0A812EA01_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_70526</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005166">
        <property type="protein sequence ID" value="CAE1320263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EA01"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1320263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="256" mass="29916" checksum="9B1E8BE0DEF8E5BE" modified="2021-09-29" version="1">MIPVSVALFVSYRFRYIYLSIYLSIYLSSYSSISVYSNLSIYLSIYLSIYLSIYLSIYLILLRSIYLSIYLSIYLSIYLILFRSFSVCSYLSIYLSIYLSIKKYRVKLSELLILISALFLSIYLSIYLSISVSSLSIYLSIYFSIYLSIYLSIYLSFFDYLSIYLSIYLSIYLMLFASLRYSLPTHSRHPPHSPPHVACISASYCLNLSSLTHQSTHLPSNSLFFFFFLVVRRLLLRYRLSSELYFLFTVPSSPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EA06</accession>
    <name>A0A812EA06_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_68846</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005028">
        <property type="protein sequence ID" value="CAE1318358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EA06"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1318358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="231" mass="28236" checksum="A65BBC3A36EFFD01" modified="2021-09-29" version="1">MFPRILHQRKICFRLSRSYFRLLYYLYFFHILKYNFCLTLSSIVYLVSRFSHSFFSFFISVENSYILTSSFFLSFFLFFFPSFFLSFLLSFFISFFRSFFLSFFLSFFSLYSFSCFSFSYFYRSLFLLKMHVFFISPFFVFISSSLPFFLPFFLSISNLYVFYFLSISHIKKKKKNISFSLLSFNFSLASIRFIFKNLSLCLWKILILSLFPFFLFFFLTIQDSHFLITQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EAW3</accession>
    <name>A0A812EAW3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SPHA_67851</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030004915">
        <property type="protein sequence ID" value="CAE1317267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EAW3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE1317267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="773" mass="81504" checksum="72E11C21D6296B27" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ED38</accession>
    <name>A0A812ED38_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_71336</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005219">
        <property type="protein sequence ID" value="CAE1321177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ED38"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="313"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="370"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="403"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1321177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="454" mass="55622" checksum="59377A8F977B8573" modified="2021-09-29" version="1">MISFLSRSFFFLSFFLSFFLSFILPSFCCSFLFRSFFFLSFFLSFFLPNFCCSFHFRSLFFLSFFILPSFCCFFPFPFVLRSVVLSFFRSSFFSFFVLPFFFRSSFFLLFFLFFVLFSFCSFLFRSFFFLSFFLSFFLSFFHSSFFLLFFPFSFVLLSFFLSFFLPSFCYSFHFRSLFFLSFFILPSFCCFFPFPFVLRSVVLSFFRSSFFSFFVLPFFFRSSFFLLFFLFSFFFLSVLSFFVRSSFFLFSFFLLPVVLSFLFFFLSVLSFFVRSSFFLSVLSFFLYFFVSFFLLFLSFFVRSSFFFRSSFFLFFPFSFDLLSFFLSFFLLSVVLSFFVRSSFLLSFVSFFVFLPVIVSPFCYSSFISFYFLFLSLILYLFLFFSFFFLLFFLYFFFLFCSFFISFYFLFSFFLLFLILYFFLLLFVLSFFSQLFIFLFLLFLQTFSASSFFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EDS7</accession>
    <name>A0A812EDS7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_73353</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005375">
        <property type="protein sequence ID" value="CAE1323470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EDS7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1323470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="195" mass="23826" checksum="D56F9F8AD4C7AA65" modified="2021-09-29" version="1">MCSHRIKAASEDRTHCIVISFFFLIFFGSLFPSCFNLFLLFLYSLFFILFHPLLFSSFSLFIIYLHFTLSLFFSSLFIPLYCFSFFNLYILFSLLVSFIFLLLFLFIFLLFFFFLFSLIFFFFSYLFFSFSSLCSFRTLHSFFLFVFPSFSHFLFFSFFFIRFIMFLLFHAQNSFFFFSLILFFSFFALVFKLFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EE67</accession>
    <name>A0A812EE67_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_71963</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005280">
        <property type="protein sequence ID" value="CAE1321959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EE67"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="150"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1321959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="247" mass="28302" checksum="4A9681725955D22C" modified="2021-09-29" version="1">MMCPLSIFSLARRHFFFHIIISSDILFSLLLLLLSLHFLRCYILTFEIQSFSLLLSHVRSISFFSYLSIYLSIYLSIYLSIYLSINFTLFLSIYLSISLSIYLSIYLSIYLSIDQFHSFPIYLSIYLPIYLSDSVIYLSIYLSIYLSIYLSYSLCLCISFFLSFSRALSLSLSLTPLFLSDRPTNPLMKSETVLQSPPPPLPCRSPSNTDPRPPAASLVSLSALFDVNNTRPSSAQIQHIVESQFTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EF96</accession>
    <name>A0A812EF96_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_72014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005285">
        <property type="protein sequence ID" value="CAE1321988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EF96"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23304:SF189">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23304">
        <property type="entry name" value="SPOT2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="298"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="336"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="392"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="417"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1321988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="493" mass="58578" checksum="B797B45006294580" modified="2021-09-29" version="1">MFLHTSPTYLDRHLSLSLYLCSYLSIYLSIYLSIYLSIYLSIYVCSYLSIYLSIYASYSLSIYLSIYLSIYLSIYLLASLLPSYLSIYLSIYLSTYSLHIYLSIYLSIYLSIYLSIYLSIYLVASLLPSYLSIYLSIYLSIYLLTPFISIYLSIYLSIYLSIYHIYLSIYLSIYLSIYLVASLLLHIYLSIYLSIYLSIYLSIYLSIYLVASLLPSYLSIYLSIYLSIYLSIYLSIPIEEMQEIYKNNSLKNETKKAKKKQKTKQKSFLYALFSFPINFSYFHSFLPSYVSFPSLFTLFFFILPAFLILSFILLISFSFPLFFLNPHTSSPNPATFLYFPSLILDIVSRVSLLITNFILFLCLRIHFRFSFFLSFFLSFFLSFFLSFFFKYLSFFLSFFISSFLQISFFFLSSFRSFFLSIFLSFKYFLSFFFLSFFLSVFFLSSFFLLNIFSLLSLLLIFFLLNIFFLSFFLSFFLSFKYFSFLSFFFSFFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EIG2</accession>
    <name>A0A812EIG2_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Beta-hexosaminidase</fullName>
            <ecNumber evidence="7">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SPHA_73093</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Farmed</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="7"/>
    <dbReference type="EMBL" id="CAHIKZ030005360">
        <property type="protein sequence ID" value="CAE1323243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EIG2"/>
    <dbReference type="OrthoDB" id="428480at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006689">
        <property type="term" value="P:ganglioside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030203">
        <property type="term" value="P:glycosaminoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06562">
        <property type="entry name" value="GH20_HexA_HexB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000063">
        <property type="entry name" value="Beta-hexosaminidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029019">
        <property type="entry name" value="HEX_eukaryotic_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="BETA-HEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600:SF21">
        <property type="entry name" value="BETA-HEXOSAMINIDASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14845">
        <property type="entry name" value="Glycohydro_20b2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001093">
        <property type="entry name" value="B-hxosamndse_ab_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="beta-N-acetylhexosaminidase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 7 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-hexosaminidase eukaryotic type N-terminal" evidence="11">
        <location>
            <begin position="91"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 20 catalytic" evidence="10">
        <location>
            <begin position="172"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR001093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001093-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAE1323243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="528" mass="61129" checksum="53274CFA594F3A7F" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EJ15</accession>
    <name>A0A812EJ15_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_76440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005489">
        <property type="protein sequence ID" value="CAE1326886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EJ15"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1326886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="320" mass="38188" checksum="A808032A7214AA1F" modified="2021-09-29" version="1">MFLSFFYFLIEIISSMFQLFINSPFSTSSVFFHLCLYLIISLFFLSCCQTFPRFPISIYLSIYLSIYLSICLSVCLSVSLSLYTYPSICLFISRFILIYLSIYLSIYLSIYLSIYLSIYFYLSLFRSLSLFLSLSIYLFISQFIPISPYLSIYLSVHISVYSHLSLSIYLSIYLSMTPFYIRLFLSIYLSIYLSIYLFILVFKQYLVFSHTIEISFFSHSSISLFHPHFFSERHSYIISLFSTSILFLFFLSFFLSFFLSFFLSFFLSFHHNHFNLSISFVFFVNFLSFFFLSFLFSFFLSFFLSFFLSFFLSFFPSQPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EJP2</accession>
    <name>A0A812EJP2_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_72483</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005327">
        <property type="protein sequence ID" value="CAE1322518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EJP2"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1322518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="279" mass="34276" checksum="3115279C66CF9397" modified="2021-09-29" version="1">MIFLFHFLFSSFFSLFPCFFLFLLSFSFISFLSFLFFFFFIFVHFIFFHLLSFLLFFFDFFFFFSLLLYFSLIFPCLFPFFFFHLFSFRFYFFFVSFSSFFFFFSLSFHFYHSPFTFSTLSFLFPFLFLLSFHFSLSSLLPFLFFFFFVYFIFFHLLSFLFFFFEFSLFLLSSSFFSLLFLFLFSFLFFLFSSFSFTFPFSYVLFFFFSIFLFLLSSFFLSFFLPISLLFLFISLNIISFLPSFFLSFFLFFPFFLIFSFSPIASTSGALFSEITAIPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EJR1</accession>
    <name>A0A812EJR1_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_73785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005392">
        <property type="protein sequence ID" value="CAE1323974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EJR1"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="323"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="351"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="383"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1323974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="409" mass="52017" checksum="16B4F393749EA7C0" modified="2021-09-29" version="1">MVTSVTNRQINSFRFKNTFFKKNCIFSFSFISSFSTISSFSFISFLSFIFSLSFISSFSLIFFSFFHYFIFFLSSFIFISSFPFIFFIFFHFFFFFYFSLFFYFFIFHFFLFFHFFFFLLSIFPFFSFFYFLIFFPFSSYLISSFSFISFTFISSISFIFFCFFHLFFFSHFFIFFNFFFSFIFHFLSFLHLVYFSFSFISSFSFLSFFFHFFRFFIFLPFFFFLSFILFLLCIFHLLLFFYFLIFSIIFFFHFFIFFHFHFFTFFHLFFFLHFFIFLPLFFYFHFFLFLHFFIFHLFLFFHFFLFHLFFFVHFFIFLPFFSFFLFFIFIRFFFKLFLILSFLHFLSFPLLVSFLLFLSFLQIVSFLHFLSFLLLLSFIRFLSFILFFFYLIFHFLFFFYFLIFFPFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EJZ3</accession>
    <name>A0A812EJZ3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_73804</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Cephalopoda</taxon>
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            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005396">
        <property type="protein sequence ID" value="CAE1324005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="entry name" value="Expansin, cellulose-binding-like domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
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        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
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        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <end position="212"/>
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            <end position="324"/>
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            <end position="391"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="415"/>
        </location>
    </feature>
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            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="491"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1324005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="513" mass="59369" checksum="E3DD2FAAFC11F4AE" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EK34</accession>
    <name>A0A812EK34_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_74524</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
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            <taxon>Mollusca</taxon>
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            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAE1324873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="210" mass="24788" checksum="C27C4C7CF1D27C9D" modified="2021-09-29" version="1">MHIYLSIYLFIYLNMFVSIKITSYLIKKLSRYSIPHNTIYLSIYLSIAIFSYLSIIPSYSFNNLAPFISIYLSIYLSIYLSIYLSVVIFSYLSNTIISYLINKLVPCISIYLSIYLSIYLSISVYQYQYLCTNVNIYLSIYLSIYLSIYLFLCININIYVPMSISIYLSIYLSIYLSVYHAYLSIYLSICLKMPSKNHEYKFFLHLKLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EKA5</accession>
    <name>A0A812EKA5_ACAPH</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">Farmed</strain>
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    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EKY2</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">SPHA_75026</name>
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    <organism evidence="2 3">
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            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
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    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005447">
        <property type="protein sequence ID" value="CAE1325392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAE1325392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="236" mass="27269" checksum="A7F3E97ED643A6E5" modified="2021-09-29" version="1">MYIQISLSLSLSFYLSIYLSIYLSLILSIYLSIYLSIYRLVFHFSLSLYVCLSLSLSLFHSFHNLPTSIFAIFLSLRSKHLNSATPQTLSLPKIFSRLFIPTLTLSSFQLYILLYPSPDLYLLLHSIYLSIYLSIYLSIYLSIYLFPLFYLLSISLFFQSLSLENYILPLYFSNHTPSHYIFYLVNFSLFITTIISSIFHNLSVFPISLLPQSIYLAKLSLAPLSLSPQSLSLFPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EQ97</accession>
    <name>A0A812EQ97_ACAPH</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
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        <dbReference type="NCBI Taxonomy" id="158019"/>
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            <authorList>
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                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005446">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EQ97"/>
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    </dbReference>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1325356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="219" mass="26525" checksum="17FD33AFDB749FC5" modified="2021-09-29" version="1">MWLTQRHPLSLSLCFLFSRCVYLSIYLSIYLSIYLSIYLSILFYSLCIYLCIYIILFIIYLSIYLSQSEIFYLSIYLSIYPRLNFSFFLSFFLSFFLSFFLEFYFILFPIYLSIYLSIYLSIYLSIYLSISDYALSIYLSIYLSIYLSMSLHIYLSSISYYSLYIYFILLSIYLSIYLSIYLYLFIYIYHLSHSIHYTSIYLSQTMLYLSIYLSIYLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EWS9</accession>
    <name>A0A812EWS9_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="13">TOM70</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SPHA_78664</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Farmed</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Tom70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005547">
        <property type="protein sequence ID" value="CAE1329122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EWS9"/>
    <dbReference type="OrthoDB" id="66418at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030943">
        <property type="term" value="F:mitochondrion targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46208">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46208:SF1">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 10" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="2 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="202"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="81"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="120"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAE1329122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="304" mass="34201" checksum="4A98683B92E835C4" modified="2021-09-29" version="1">MAMDKLSMRMERLREMVQGQLEGLSKWQLALLFGTPVTLGLVGFIYYKSKKHKKKSDCKGNSAAGARSKEREAEPPLIDQAVETKKRGNTLFKAGKYTEAIDCYTGAIALCPLDRPDQLATFYQNRAAAYDQLNNHKQVVSDCSRALRLNPKYAKALSRRAKSADQLGDLKLAIEDLTFLCMLENFANEETVKFSERNAPKFFLSPSLTFFLSPSLTFFLSPSLTFFLSLSNFFSSPSFFPLSLSNFFPLSLSNFFPLSLSNFFPLSLSNFFPLSLSNFFLSLSFFSPSLTFFSPSLTFFPSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EY14</accession>
    <name>A0A812EY14_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DENND5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SPHA_79758</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005576">
        <property type="protein sequence ID" value="CAE1330444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EY14"/>
    <dbReference type="OrthoDB" id="6019893at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047278">
        <property type="entry name" value="DEN5A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005113">
        <property type="entry name" value="uDENN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46070">
        <property type="entry name" value="PINSTRIPE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46070:SF1">
        <property type="entry name" value="PINSTRIPE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00800">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="331"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="368"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="436"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="505"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="548"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="586"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="618"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="651"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="680"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="726"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="757"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="789"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="domain" description="uDENN" evidence="2">
        <location>
            <begin position="7"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE1330444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="811" mass="87554" checksum="C0C59C1B7E7D29CD" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812EYZ0</accession>
    <name>A0A812EYZ0_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_79728</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005575">
        <property type="protein sequence ID" value="CAE1330393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812EYZ0"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1330393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="171" mass="21387" checksum="CDF0FF222D369D66" modified="2021-09-29" version="1">MYIFCFFLFYFLNFLSFFSFFLFILFYFLIYLLSFFLSLVIFLFYFLDLLSFFLSFFLSFIYLFSFFFFLSFFLSFIYLFSFFFFLSFQYLLFSFVLSFFLSFFLSFFYLFIFFLSFSFFLSLFLLFIYFLSFSFFPSSICYFLSFFLSFFLSFFLSLSVCLFPVDIILFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812F170</accession>
    <name>A0A812F170_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_81571</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030005638">
        <property type="protein sequence ID" value="CAE1332532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812F170"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="307"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1332532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="338" mass="40303" checksum="21D26747E6AE4B6C" modified="2021-09-29" version="1">MMMMTIIIIIIIKLFSYFHFSFLPSSHARFLFSFSLSFSFLRSFLIFLFLSLLLLTIFSYFPFPFPTFFSRSFIVHLYLFLLLFTLLFSSSVSSSFFSHDFLILLFLSLLLLTIFSYSPFSFPSSFHALFLFFFFFSPIFHVLFLSPFLLPPSAHAHFYSPFLFPTFSRLFLFSFTFTSYSYHSLFFFSFFFSLFFQRSFLMLLFILLLTFFFPFSFPSFFSRSFLFFSSFFPRSFLIPFSFLSLVSHTFLILLFLFLLTLFSYSPFSFSPFSHAHFFNLFLFLLLLTPFSYSPLSFPPSHVPFSFIFSYSFIIHLLFRLNLNLSFFLLLLLFPTPHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AKN2</accession>
    <name>A0A812AKN2_ACAPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">KAT8 regulatory NSL complex subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">NSL complex protein NSL2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Non-specific lethal 2 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">SPHA_685</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Farmed</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Non-catalytic component of the NSL histone acetyltransferase complex, a multiprotein complex that mediates histone H4 acetylation at 'Lys-5'- and 'Lys-8' (H4K5ac and H4K8ac) at transcription start sites and promotes transcription initiation. Required for NSL complex stability and for transcription of intraciliary transport genes in both ciliated and non-ciliated cells by regulating histone H4 acetylation at 'Lys-5'- and 'Lys-12' (H4K5ac and H4K12ac). This is necessary for cilium assembly in ciliated cells and for organization of the microtubule cytoskeleton in non-ciliated cells. Required within the NSL complex to maintain nuclear architecture stability by promoting KAT8-mediated acetylation of lamin LMNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the NSL complex at least composed of KAT8/MOF, KANSL1, KANSL2, KANSL3, MCRS1, PHF20, OGT1/OGT, WDR5 and HCFC1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000017">
        <property type="protein sequence ID" value="CAE1140777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AKN2"/>
    <dbReference type="OrthoDB" id="677315at2759"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044545">
        <property type="term" value="C:NSL complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026316">
        <property type="entry name" value="NSL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025927">
        <property type="entry name" value="Znf_KANL2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13453">
        <property type="entry name" value="KAT8 REGULATORY NSL COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13453:SF1">
        <property type="entry name" value="KAT8 REGULATORY NSL COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13891">
        <property type="entry name" value="zf-C3HC3H_KANSL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="189"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="271"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="KANL2-like probable zinc-finger" evidence="16">
        <location>
            <begin position="35"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="85"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00093359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00093543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF13891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAE1140777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="300" mass="34849" checksum="6D12CA328EF9AE11" modified="2021-09-29" version="1">MLEDCNTRMSFHRMNRTKNNVMKRQVKVPVEGLFCNYNHRVCMQNRLEGSDYCLKHILEDKNSPYKQCSYVANKTGKRCPNAAPKADRKDEEPKKRDQFIKRHAGVYTAEEVALILRDKLIRLQSLYIDQFKRLQHVMKERRRKYLHTYKQERDTLGSIEAYKNSPEHRDKYAKFVAMKRHHRRFCKSVSLSLSLSLSLSLSLSSLSLLSLFLSLSFSFSLSLFLSLSLSFSLSLSLFSFLSLSLFSLSLSFFSLSLFSLSFSLLSLSLSFLSLFLSLFLSLFSLSLFSLSLFSLSRFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812ALI7</accession>
    <name>A0A812ALI7_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_549</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000011">
        <property type="protein sequence ID" value="CAE1140325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812ALI7"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="290"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="346"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="375"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1140325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="399" mass="43692" checksum="E634E6F41639AF2F" modified="2021-09-29" version="1">MFADPDIPHTLPCLPSSPSLLSLSLSLSLVLILSSPGSIFFTSPPLCYVFYSLPHPSTQVFSFSPLVQFSLSPPGSVFPLSPGSVFLSPPWFSFPSLPCFSFPLSPCSVFPLSPVQFPSLSLFSFPSLPPVQFSLSPCSVFPLFPSLCFLLSLPPYCFFALSPPYCFLLSLPYCFWLSLPLTVFLALSTPYCFLALSPPHCFLALSPPHCFLALSPPHCFLALSPPHCFLALSLSHSLCFLLSFSHSLCFCSLSHSLCFFALSLPLTLFFAFSLPLTLFFALSLSHPLCFLLSLSPTHSVFCSLSLPLTLFFALSPHHTVCLSLFFSLCVPLPLSLPVFLSLSLPLALFSSFSVPHSVFFSLLLCPFLCSFPFSVLSPLSLLSVSYLPNSYIFYFIIST</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AM65</accession>
    <name>A0A812AM65_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_3026</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000088">
        <property type="protein sequence ID" value="CAE1150808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AM65"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="332"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1150808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="382" mass="44811" checksum="A4B354697BB9B09E" modified="2021-09-29" version="1">MSGCQRLISSSLIVARLHCFLGFAFPAFYLISPSSLCSALFNSFFPPYHTFQTNKSYFEYIIFCLFLFHSLSLSLSIYLSIYSPSSLFFNFLPLYFYSSYTFFFLSFVLSFFFHLNITFLSHPSSFLPHFSCLFFFFYFSLLASSPFLFLTLVPYFQPFFSFTFLSIYIHSSFLLSFSIPPPPSPIFFYSSFAHLTFFQSFLSLTLLLCFFCLCLCHIFFVNYLSISFNLFFFLLFCYFFSLSLSLSHTHTYTHTRTRPPFLSFLSASFSSSSFVSFFIHSLSHAPSLFLSFSVSFFFCFFLFLFLSFSVSFHPHSRPLLFFFSRFPLTQTLYWHTPFAPFSYFISPFFFHFFFHLPTSPPLSLSYLVKLSATYSLSLSQTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AMZ3</accession>
    <name>A0A812AMZ3_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_3416</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000102">
        <property type="protein sequence ID" value="CAE1152397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AMZ3"/>
    <dbReference type="Proteomes" id="UP000597762">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="290"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="366"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="403"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="434"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE1152397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000597762"/>
        </source>
    </evidence>
    <sequence length="463" mass="53394" checksum="A98D5930946C8C9F" modified="2021-09-29" version="1">MLSFPLFRCLYLLFRSFSLPPSLSLSLSLSLSLSLSLFMFLFHISLFILLIAYLSSPLSLSLHLAFSILFQFFNWRPPLPPPLIVTHSLSLSLSYYVRVRVCVCFSLYHVLLSSFSLLLPPCVSFLITTCLFIFLLPSIPILIAIFFHFIPLAIFLCVRVCVCVCLSLSDYLSYTHFLSSIFLFLCNSSFSLSLHLCISRSLSPSPSPSLYYLSIYLSIYLSIYFLYFYVSVCVSPCLSVSLSLSHSLSDYLSFTHFISSIFLFLCNSSFSLSRFLHVCISRSLSLSLSLSVSLLSIYFLYFYLCVCLSLSLLDYLSHTHFLSSIFLFLCSSSFSLSLSLSLSLSFSCRYDCGLLNNFLYSSIVPFPYAFLNIPFSLFLFSAIFLFLFSFFLHVHDCYLPIRFLFPIIYSIHFICLYLFLSSSLFSFYSLSFSLFLFFIFFFFFFFFLLLLLLLLLLYFFILI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A812AN23</accession>
    <name>A0A812AN23_ACAPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SPHA_2068</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthosepion pharaonis</name>
        <name type="common">Pharaoh cuttlefish</name>
        <name type="synonym">Sepia pharaonis</name>
        <dbReference type="NCBI Taxonomy" id="158019"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Cephalopoda</taxon>
            <taxon>Coleoidea</taxon>
            <taxon>Decapodiformes</taxon>
            <taxon>Sepiida</taxon>
            <taxon>Sepiina</taxon>
            <taxon>Sepiidae</taxon>
            <taxon>Acanthosepion</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Li R."/>
                <person name="Bekaert M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Farmed</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAHIKZ030000058">
        <property type="protein sequence ID" value="CAE1147113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A812AN23"/>
  